Best TWAS P=9.3e-36 · Best GWAS P=1.15e-54 conditioned to 1.75e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | USP36 | 0.11 | 0.04 | enet | 13 | 0.06 | 1.1e-04 | -5.02 | 5.8 | 6.5e-09 | -0.07 | 0.21 | 0.72 | TRUE |
| 2 | GTEx | Esophagus Muscularis | USP36 | 0.18 | 0.16 | lasso | 3 | 0.08 | 2.5e-05 | -5.01 | -5.1 | 3.0e-07 | 0.12 | 0.10 | 0.90 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TMC6 | 0.07 | 0.01 | blup | 63 | 0.03 | 1.8e-06 | 15.57 | -10.6 | 5.1e-26 | -0.40 | 0.00 | 0.96 | FALSE |
| 4 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TMC8 | 0.11 | 0.07 | lasso | 6 | 0.07 | 9.4e-09 | 7.74 | 11.9 | 7.8e-33 | 0.77 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TMC6 | 0.08 | 0.04 | lasso | 3 | 0.04 | 7.0e-05 | 4.86 | -12.5 | 9.3e-36 | -0.59 | 0.01 | 0.88 | TRUE |
| 6 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | SYNGR2 | 0.52 | -0.01 | blup | 53 | 0.08 | 4.1e-03 | 15.57 | 8.5 | 1.7e-17 | 0.54 | 0.00 | 0.76 | TRUE |
| 7 | The Cancer Genome Atlas | Stomach Adenocarcinoma | TMC8 | 0.12 | 0.00 | blup | 62 | 0.02 | 1.4e-02 | 0.31 | -6.9 | 5.5e-12 | -0.18 | 0.02 | 0.03 | TRUE |