Hub : Genes

SYNGR2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Liver	0.3450	0.1200	5.6e-03	0.029	NA	0.124	NA	0.058	5.3e-02	NA	2.6e-04	NA	1.0e-02
2	GTEx	Nerve Tibial	0.1630	0.0554	3.4e-03	0.046	NA	0.051	NA	0.044	3.4e-04	NA	1.7e-04	NA	4.6e-04
3	GTEx	Pituitary	0.5830	0.1260	7.3e-04	0.074	NA	0.030	NA	0.067	6.6e-03	NA	6.1e-02	NA	9.2e-03
4	GTEx	Vagina	0.5740	0.1380	5.0e-03	0.002	NA	0.002	NA	-0.012	2.8e-01	NA	2.8e-01	NA	7.7e-01
5	TCGA	Breast Invasive Carcinoma	0.0470	0.0180	9.9e-06	0.011	0.020	0.019	NA	0.024	1.7e-03	3.9e-05	7.4e-05	NA	9.8e-06
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0945	0.0356	6.7e-04	0.001	0.018	0.013	NA	-0.002	2.4e-01	3.8e-03	1.1e-02	NA	6.4e-01
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0899	0.0336	2.0e-05	0.068	0.052	0.060	NA	0.055	3.8e-08	1.7e-06	2.6e-07	NA	7.9e-07
8	TCGA	Lung Adenocarcinoma	0.0659	0.0228	1.7e-06	0.063	0.056	0.064	NA	0.061	6.5e-08	4.2e-07	6.2e-08	NA	1.2e-07
9	TCGA	Skin Cutaneous Melanoma	0.5170	0.0920	1.1e-04	-0.006	0.078	0.011	NA	-0.007	4.9e-01	4.1e-03	1.6e-01	NA	5.4e-01
10	TCGA	Thyroid Carcinoma	0.1350	0.0370	4.5e-11	0.079	0.130	0.128	NA	0.123	3.6e-08	1.3e-12	2.1e-12	NA	5.1e-12

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	1.1	1.7	5.4	0.4	-0.7	1.9	-0.9	1.5	-0.5	0.8	0.7	2.3	1.8
Bipolar Disorder or Schizophrenia	0.5	1.3	6.5	-1.1	-0.9	0.7	-1.1	-0.0	-1.1	0.1	-0.2	2.5	1.1
Depressed Affect (Nagel 2018)	0.8	1.6	4.4	-0.3	-1.0	1.2	-0.8	0.7	0.9	1.8	1.6	1.1	2.1
Depression (Nagel 2018)	0.8	1.2	3.8	-0.3	-2.0	1.1	-1.1	0.2	-0.7	0.9	0.2	0.7	1.9
Intelligence (Savage-Jansen 2018)	0.1	0.3	2.1	0.1	-0.1	-0.2	-0.4	-0.4	-0.3	0.3	-0.2	1.5	-0.0
Neuroticism (Nagel 2018)	0.8	1.9	3.6	0.2	-1.0	1.4	-0.7	1.0	0.5	1.9	1.9	1.8	1.9
Schizophrenia (2018)	0.4	0.9	2.6	-1.6	-0.6	-0.5	-0.7	-1.2	-1.0	-0.6	-0.8	1.3	-0.2
Schizophrenia vs Biploar Disorder	0.8	1.1	4.2	-1.6	0.9	-0.5	-0.2	-0.4	0.4	-1.3	-1.1	-2.1	-0.2
Worry (Nagel 2018)	0.5	1.1	2.8	0.5	-0.5	0.7	-0.3	1.1	1.0	1.5	1.4	1.7	1.0
Alzheimer’s Disease (in mother)	0.3	0.3	1.1	-0.0	0.7	-1.0	0.2	-0.9	0.4	0.2	-0.1	0.6	-0.4
Alzheimer’s Disease (in father)	1.3	1.4	3.3	0.3	-0.8	1.4	0.3	1.5	-0.3	1.5	1.8	-1.2	1.2
Alzheimer’s Disease (including proxy)	0.2	0.3	1.3	0.4	0.1	-0.4	0.3	0.1	0.3	1.1	1.2	-0.1	0.4
Crohns Disease (2017)	0.7	1.5	3.4	0.7	0.1	1.6	0.1	1.4	1.5	1.7	1.8	0.1	1.3
Irritable Bowel Disease (IBD)	0.9	2.1	4.2	-0.3	0.9	1.6	-1.0	1.6	1.9	2.0	1.8	0.6	1.6
Ulcerative Colitis (UC)	0.6	1.0	2.3	-0.9	1.3	0.6	-1.5	0.8	1.5	0.9	0.7	0.5	0.8
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.6	1.1	7.7	-1.0	-0.8	-0.2	2.8	-0.3	0.2	-1.2	-0.1	-0.5	-0.1
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.3	0.0	-1.1	0.5	-0.1	0.2	-0.3	1.1	0.9	1.1	0.5
Breast Cancer	0.3	0.8	3.0	1.6	0.2	-0.5	-0.5	-1.0	-0.2	-0.3	-0.7	0.6	-1.7
Ovarian Cancer	0.5	0.7	2.3	0.2	-0.7	-0.2	0.7	-1.1	-0.8	-1.1	-1.5	0.6	0.3
Prostate Cancer	1.9	2.7	4.6	-1.7	1.8	-1.6	0.9	-1.8	1.3	-1.7	-2.1	2.0	-0.9
Age at First Birth	0.6	0.8	2.4	-1.0	-0.3	-0.6	-1.5	-0.9	-1.2	-0.4	-1.4	0.0	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.5	-0.2	0.0	0.4	-0.8	0.3	-0.0	1.1	0.5	1.2	0.3
Coronary Artery Disease (CAD)	0.6	0.7	5.0	1.4	0.2	0.7	-2.2	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.4	0.7	5.4	-0.1	1.1	2.3	-0.4	0.0	0.0	0.0	0.0	0.0	0.0
Mean Putamen Volume	0.5	0.6	1.3	-1.0	1.1	0.1	-1.2	0.2	0.7	0.2	-0.5	1.1	0.8
Fasting Glucose	0.4	0.4	1.7	-1.3	0.8	-0.3	0.7	-0.1	0.3	-0.2	0.5	-0.6	-0.7
HbA1C	2.1	2.3	6.5	0.1	-0.8	2.5	1.5	1.4	-0.1	1.4	0.3	2.0	2.4
HDL Cholesterol	0.2	0.4	2.2	0.3	-0.3	1.5	-0.5	0.7	0.0	0.4	0.5	-0.5	0.1
LDL Cholesterol	0.6	1.0	2.6	0.6	-0.5	1.6	0.3	1.6	1.2	0.7	1.0	0.1	0.9
Lupus	0.4	0.5	2.2	0.9	-0.3	1.5	-1.1	0.1	0.3	0.2	0.0	-1.1	0.2
Neuroticism (2016)	0.2	0.3	0.7	0.3	-0.8	0.0	0.4	0.8	-0.2	0.6	0.7	-0.2	0.7
Primary Biliary Cirrhosis	0.6	0.8	3.9	-2.0	0.5	-0.7	0.2	-1.1	-0.2	-0.3	-1.0	1.0	-0.3
Rheumatoid Arthritis	0.7	0.9	3.6	0.9	-1.9	1.0	-0.7	0.8	-0.5	0.8	0.7	-0.9	0.6
Schizophrenia (2014)	0.5	1.1	4.4	-1.5	-0.3	-0.0	-1.0	-0.7	-0.9	-0.3	-1.1	2.1	1.0
Triglycerides	0.5	0.8	2.8	-1.7	0.3	-1.4	0.7	-0.5	-0.4	-0.6	-0.8	-0.1	-0.9
Type 2 Diabetes (T2D) (2012)	0.4	0.4	2.7	-0.5	1.6	-1.2	-0.4	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.5	0.8	2.2	-1.0	1.2	1.5	-1.4	0.9	0.0	0.0	0.4	0.0	0.0
Blood Eosinophil Count	0.2	1.4	7.2	0.0	0.9	0.7	0.1	1.3	1.5	-0.0	1.3	-2.7	0.3
Blood Platelet Count	0.6	6.4	26.8	5.2	-4.4	1.0	1.5	0.5	-0.4	-1.3	0.6	-3.5	-0.8
Blood Red Count	1.6	15.4	72.6	-3.8	4.4	-0.4	-3.5	-1.5	-0.8	-2.3	-5.1	8.5	0.9
Blood White Count	0.5	3.6	9.2	0.5	2.3	2.8	0.1	2.3	3.0	-0.3	0.6	-2.2	1.6
Heel T-Score	0.3	2.3	13.3	-0.8	-1.9	0.3	0.5	0.4	-3.6	-0.5	0.5	-2.1	-0.4
BMI	0.2	1.4	9.3	0.1	-1.6	0.7	0.7	0.4	-3.0	0.2	-0.5	-1.0	0.4
Height	1.2	22.5	69.4	-4.8	8.3	-5.3	1.6	-5.6	3.5	-4.3	-4.8	-0.8	-4.0
Waist Hip Ratio (WHR)	0.7	3.0	6.5	-1.6	2.3	-1.7	1.4	-2.5	-0.2	-1.3	-2.1	-0.2	-2.2
Systolic Blood Pressure	0.3	1.5	6.9	0.7	0.7	0.4	-1.6	0.1	-0.1	-2.6	-1.8	-1.0	0.4
Smoking Status	1.2	2.8	6.5	-1.7	2.0	-1.4	-1.1	-1.4	0.3	-2.6	-1.9	-1.4	-2.0
Allergy or Eczema	0.8	2.2	6.7	2.6	-1.2	1.2	-1.3	1.5	0.2	0.7	2.0	-1.9	-0.3
Cardiovascular Disease	0.6	1.9	4.9	-1.0	1.0	-0.7	-2.2	-1.3	-1.1	-1.6	-2.0	-0.8	-1.2
Hypothyroidism (self reported)	0.4	0.8	2.7	-1.6	0.5	-1.5	0.6	-0.7	-0.4	-0.5	-0.7	-0.2	-1.1
Respiratory disease	0.6	1.2	6.3	1.3	0.6	-0.3	-0.7	0.3	0.3	-1.5	0.4	-2.5	-0.8
Type 2 Diabetes (T2D) (2018)	1.4	2.7	8.7	2.9	-1.7	2.0	-0.6	1.6	-2.0	0.2	1.4	-1.2	0.5
Lung FEV1/FVC ratio	0.1	0.4	1.3	-0.7	-1.1	0.5	-0.1	-0.4	-0.6	0.4	-0.6	0.4	0.6
Lung FVC	0.1	0.6	4.0	0.8	-0.1	-0.6	-2.0	-0.2	0.1	-0.0	0.3	-0.2	-0.9
Neuroticism	0.1	0.3	1.5	-0.6	-1.2	0.1	0.9	0.2	0.2	-0.1	0.3	0.2	0.5
Chronotype (morning person)	1.7	4.0	9.0	1.7	-3.0	1.3	2.1	2.8	-0.6	1.3	2.7	-2.2	0.0
Hair Pigment	0.0	0.9	2.2	0.6	0.3	0.7	-0.7	0.9	-1.5	1.4	0.8	-0.4	1.2
Tanning	0.1	0.8	2.2	0.3	-1.5	-0.7	0.7	-0.1	-0.2	-0.4	1.5	0.4	-1.5
Hand grip strength (left)	0.7	1.9	5.2	-1.2	2.2	-1.2	-2.3	-1.4	0.2	0.6	-1.4	1.3	-0.4
Number of treatments/medications taken	0.5	1.0	1.9	-0.5	0.5	-0.9	-1.3	-0.9	-0.6	-0.8	-1.2	-1.2	-1.4
Average weekly spirits intake	0.3	0.4	1.3	-0.5	0.6	-0.3	-0.3	-0.8	0.7	-0.4	-1.1	-0.4	-0.6
Sensitivity / hurt feelings	0.6	1.0	2.4	-1.1	-1.4	0.5	1.5	0.6	-0.7	0.5	1.1	1.2	0.2
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.7	0.2	-1.6	0.8	-1.4	-0.0	-1.6	-0.2	-0.1	-1.2	1.0
Hearing difficulty/problems: Yes	0.4	0.5	1.4	0.6	0.2	0.4	-1.1	-0.6	-0.5	-1.1	-1.2	-0.5	-0.5
Relative age of first facial hair	0.2	0.4	1.1	0.3	-0.8	0.6	0.7	0.1	0.5	-0.8	-0.7	1.1	0.5
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.6	0.9	-0.7	0.5	1.6	-0.0	1.1	1.3	0.4	1.4	0.3
Ever used hormone-replacement therapy (HRT)	2.2	2.8	8.9	-3.0	0.5	-1.4	-1.3	-1.3	-1.5	-1.7	-2.1	-0.2	-1.9
Ever had hysterectomy (womb removed)	0.4	0.4	1.1	-0.3	-0.6	-1.0	0.5	-1.0	-0.1	-0.3	-0.8	-0.0	-0.8
Systolic blood pressure, automated reading	0.4	1.2	4.6	0.8	-0.9	-0.3	-1.0	0.1	-1.6	-2.1	-1.4	-0.8	-0.6
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.7	0.6	-0.6	0.3	0.3	0.2	0.2	0.8	0.8	0.2	0.4
Angina	0.4	0.5	1.0	0.6	0.2	0.2	-1.0	-0.2	0.9	-0.7	-1.0	0.6	-0.6
Medication for hormone replacement therapy	1.0	1.1	4.2	-1.8	0.7	-0.2	-0.6	-0.2	-0.5	-1.1	-2.0	-0.9	-0.4
Vitamin and mineral supplements	0.4	0.5	2.3	-0.1	0.6	-1.5	1.0	-0.5	0.1	-0.3	-0.7	-0.3	-0.6
Supplements: Zinc	0.4	0.4	2.1	-1.5	-0.4	-0.0	0.5	-1.0	-0.2	-0.1	-0.9	-0.2	-0.0
Medication: Co-codamol	0.8	0.9	3.1	0.1	0.8	-1.4	0.0	-1.2	0.2	-1.1	-0.5	-0.6	-1.8
Medication: Metformin	0.7	0.9	2.6	1.6	-0.9	0.3	-0.8	0.5	-1.6	-0.9	-0.0	-1.2	-0.3
Diabetes (father)	1.5	1.9	5.9	1.7	-1.6	1.5	-0.1	1.1	-1.4	1.0	1.0	-2.4	0.1
Diabetes (mother)	0.9	1.1	2.7	-1.2	-0.3	-1.5	0.9	-1.5	-1.6	-0.3	-0.6	-0.3	-1.2
Severe depression (siblings)	0.6	0.6	2.3	-1.5	0.9	-1.1	0.3	-0.2	-0.2	-0.2	0.2	1.0	-0.8
Pack years adult smoking proportion	1.0	1.5	4.8	-0.6	1.2	-1.7	2.2	-1.5	-0.6	-1.0	-0.9	0.8	-0.8
Impedance of leg (right)	0.2	1.0	4.2	0.1	1.0	-1.1	0.7	0.1	2.1	0.2	1.3	0.9	-0.6
Leg fat-free mass (left)	0.3	1.7	4.9	-2.0	2.0	0.0	-0.7	-1.1	0.2	-0.7	-2.2	-1.3	-0.1
Trunk fat percentage	0.2	0.8	2.2	-0.5	0.6	-1.0	1.5	-0.8	-1.4	-0.5	-0.3	0.2	-1.0
Hand grip strength (right)	0.3	0.8	5.7	0.2	0.5	-0.0	-2.4	-0.3	0.2	0.8	-0.6	0.8	0.2
Townsend deprivation index at recruitment	0.7	1.0	5.4	0.0	0.0	0.2	0.3	-0.9	-1.1	-2.3	-1.4	-0.1	-0.3
Current tobacco smoking	0.6	0.9	2.7	-0.5	0.5	-1.4	-0.1	-1.1	0.3	-1.6	-0.9	-0.9	-1.2
Average weekly fortified wine intake	0.9	1.0	3.8	-0.0	-0.1	-0.8	0.9	-1.8	0.7	-0.8	-1.9	0.6	-0.1
Maternal smoking around birth	0.4	0.6	1.5	-1.2	0.9	1.2	0.7	0.6	0.1	0.5	0.0	-0.6	0.5
Fed-up feelings	0.2	0.4	1.1	-0.5	0.3	0.6	-0.8	0.4	0.5	0.2	0.9	-0.3	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	4.6	0.2	-1.7	1.5	-0.7	1.0	-0.3	1.3	1.0	0.1	2.1
Relative age voice broke	0.3	0.5	1.6	0.4	-0.5	0.9	0.6	1.3	0.5	0.4	1.0	0.5	0.4
Taking other prescription medications	1.8	2.7	10.2	-1.2	0.0	-2.2	1.2	-2.0	-2.0	-0.8	-0.8	0.2	-3.2
Age when periods started (menarche)	0.3	0.6	2.2	0.5	1.1	0.6	-0.6	0.0	1.5	-0.9	-0.8	-0.7	0.0
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.5	-0.7	0.4	-0.8	0.6	-0.4	0.6	-1.2	-1.2	-0.9	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	2.9	-1.4	1.1	-1.6	1.3	-1.7	-1.6	-0.9	-0.9	0.1	-1.3
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.6	0.4	-1.3	0.6	-0.4	0.2	-0.2	0.4	0.7	-0.3	-0.3
Qualifications: CSEs or equivalent	0.6	0.8	2.0	0.8	-0.5	0.4	1.3	-0.6	-1.2	-1.0	-1.0	-0.1	-1.4
Serious illness, injury or assault to yourself	0.5	0.6	3.5	-0.1	0.9	-0.6	0.4	-0.1	1.9	-0.2	0.1	0.4	-0.9
High blood pressure	0.7	1.9	4.5	-1.6	2.1	-0.8	-1.8	-0.7	-0.8	-1.5	-1.6	-0.9	-0.7
Hayfever, allergic rhinitis or eczema	0.5	1.2	3.8	1.9	-1.2	0.7	-1.1	0.8	-0.1	0.8	1.5	-1.1	-0.4
Multivitamins +/- minerals	2.3	2.9	11.3	1.4	-1.4	3.4	-1.5	2.2	0.3	1.0	1.4	-0.0	2.1
Stomach or abdominal pain in last month	0.4	0.5	1.5	1.0	-0.7	-0.7	-0.1	-0.5	0.2	-0.1	0.3	1.2	-1.0
Supplements: Glucosamine	0.5	0.7	2.6	0.3	-1.6	0.3	-1.4	0.9	0.6	0.2	0.5	-0.6	0.5
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	3.0	-0.4	1.0	1.3	1.3	1.2	0.4	0.5	0.5	-1.0	1.7
Medication: Atenolol	1.8	2.2	8.4	-1.3	1.4	-0.8	-1.1	-1.4	0.2	-2.3	-2.9	-0.8	-0.6
Medication: Levothyroxine sodium	0.9	1.5	3.4	-0.7	0.5	-1.5	-0.0	-1.5	-1.8	-1.3	-1.4	-0.0	-1.5
Sitting height	0.4	3.2	7.0	-2.0	2.6	-1.5	-0.7	-2.1	1.2	-2.3	-1.9	-1.1	-1.4
Chronic bronchitis/emphysema (father)	0.4	0.5	1.6	-0.5	-0.4	-0.1	0.4	-0.7	-0.7	-1.3	-1.1	-0.8	0.0
High blood pressure (mother)	2.4	3.4	9.2	2.5	-1.0	2.9	-0.1	2.6	0.3	1.1	1.2	-0.0	3.0
Body mass index (BMI)	0.3	1.2	8.5	-0.1	-1.0	0.4	0.1	-0.1	-2.9	-0.3	-1.1	-1.1	-0.2
Impedance of leg (left)	0.2	0.8	1.7	0.3	1.2	-1.0	0.8	-0.1	1.3	0.0	1.2	0.7	-0.9
Leg predicted mass (left)	0.3	1.7	5.2	-2.0	1.9	0.0	-0.7	-1.1	0.1	-0.8	-2.3	-1.2	-0.1
Trunk fat mass	0.3	1.4	2.0	-1.2	1.2	-1.1	1.2	-1.4	-1.4	-1.0	-1.4	-0.3	-1.1
Waist circumference	0.8	3.0	6.8	-1.8	1.1	-1.5	1.0	-2.0	-2.0	-1.9	-2.6	-0.8	-1.8
Number of incorrect matches in round	0.3	0.5	1.5	0.7	-0.2	0.7	-0.8	0.2	1.2	-0.8	-0.7	-0.5	0.4
Past tobacco smoking	0.3	0.6	2.2	0.4	-0.4	-0.1	-0.1	0.1	0.2	1.1	0.9	1.5	1.3
Alcohol usually taken with meals	0.4	0.6	1.9	0.4	-1.4	-0.3	0.9	-0.4	-0.9	-0.2	0.6	1.4	-0.5
Nervous feelings	0.3	0.6	2.1	0.5	-0.1	0.2	-0.4	0.8	1.2	0.3	0.2	1.2	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.6	0.5	-0.5	1.1	-0.5	1.1	0.3	0.5	1.6	-0.4	1.1
Hearing difficulty/problems with background noise	0.3	0.5	1.9	0.0	-0.9	-0.5	-0.7	-0.7	-0.4	-0.7	-0.3	0.7	-1.4
Hair/balding pattern: Pattern 2	0.1	0.2	0.6	0.4	-0.0	0.0	-0.1	0.5	0.8	-0.2	0.0	0.3	-0.6
Had menopause	0.6	0.7	3.5	-1.9	0.5	0.2	-0.9	0.6	-0.2	-1.2	-0.7	-0.1	-0.6
Had other major operations	0.9	1.1	5.7	-1.7	1.0	-0.3	2.4	0.4	0.1	0.7	0.5	0.5	-0.7
Forced vital capacity (FVC)	0.4	1.6	6.3	0.7	1.8	-0.2	-2.2	-0.5	2.5	-0.7	-0.2	-0.7	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	5.2	-1.5	0.5	-1.1	2.0	-1.3	-2.3	-0.3	-0.9	1.1	-0.4
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.9	-1.3	0.7	-0.2	-0.6	-0.5	1.0	0.2	-0.6	1.4	0.1
Qualifications: None of the above	0.2	0.5	1.1	-0.9	0.4	-0.8	0.6	-0.6	0.8	-1.0	-0.5	0.9	0.1
Financial difficulties in last 2 years	0.2	0.3	1.5	-0.0	-1.2	-0.1	-0.3	0.2	0.5	-0.0	0.3	0.9	0.5
Mouth/teeth dental problems	0.5	0.7	1.5	0.9	1.2	1.1	-0.4	0.6	0.1	0.9	1.1	-0.9	-0.4
Heart attack	0.3	0.4	2.2	-0.8	0.2	-0.6	1.5	-0.4	-0.1	0.2	-0.6	-0.1	-0.5
Allergy	0.2	0.6	2.0	-0.8	0.3	0.6	1.4	0.5	0.3	0.8	-0.2	0.8	1.1
Pain all over the body in last month	0.6	0.6	1.8	-1.3	0.6	0.1	1.2	-0.0	0.3	-0.2	-0.6	1.3	0.6
Diabetes (self-reported)	0.6	0.9	2.3	1.3	-0.7	0.0	0.0	0.2	-1.4	-1.5	-0.4	-1.4	-0.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.9	1.3	-0.9	-0.0	0.4	-0.1	-1.4	-0.5	0.5	-0.8	-0.6
Medication: Ramipril	1.4	1.8	8.5	-2.9	1.8	-0.8	-0.3	-0.7	0.1	-0.9	-1.4	-1.0	-1.1
Medication: Simvastatin	0.8	1.2	3.1	0.5	0.9	-0.4	-1.4	-1.0	0.0	-1.4	-1.5	-0.8	-1.8
Fluid intelligence score	0.3	0.6	1.7	-0.3	1.1	0.3	0.3	0.4	1.3	1.0	1.3	0.4	0.4
Illnesses of siblings	0.3	0.4	1.9	-0.6	-0.2	0.3	0.8	-0.2	0.5	0.3	-0.6	0.6	1.4
Neuroticism score	0.5	1.1	2.8	-0.2	-1.6	1.1	0.8	1.3	0.4	0.8	1.7	-0.2	1.1
Weight	0.4	2.0	5.7	-1.5	1.4	-0.9	0.2	-1.7	-1.4	-1.4	-2.4	-1.1	-1.1
Impedance of arm (right)	0.6	2.8	10.3	0.3	1.7	-0.8	2.5	0.2	3.2	1.1	1.8	2.0	0.2
Arm fat percentage (right)	0.1	0.6	3.1	0.2	-0.6	0.2	1.5	-0.0	-1.8	0.1	-0.2	-0.2	0.0
Trunk fat-free mass	0.7	4.2	13.8	-2.4	2.5	-0.9	-1.4	-2.5	-0.0	-1.8	-3.7	-1.8	-1.0
Hip circumference	0.3	1.3	2.8	-1.6	0.4	-0.8	0.8	-1.1	-1.4	-1.2	-1.7	-0.8	-0.8
Time employed in main current job	0.9	1.1	4.0	0.3	0.2	-1.4	-0.3	-1.1	-0.3	-2.0	-0.4	-0.8	-1.6
Alcohol intake versus 10 years previously	0.3	0.5	2.2	1.0	-0.6	0.1	1.5	0.3	0.7	-0.3	-0.0	-0.4	0.4
Father’s age at death	0.3	0.5	1.6	-1.3	-1.1	-0.2	0.9	-0.0	0.7	0.2	-0.3	-0.4	-0.6
Worrier / anxious feelings	0.2	0.4	1.1	0.5	-0.6	-0.0	-0.3	0.4	0.5	1.0	0.9	0.6	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	3.5	0.7	-1.7	0.5	-0.5	0.1	-1.3	1.3	1.9	0.3	0.1
Falls in the last year	0.6	0.9	3.2	-0.4	-1.8	0.1	1.8	-0.3	-0.1	-0.3	-0.1	-1.3	-0.4
Hair/balding pattern: Pattern 3	0.5	0.8	4.0	-0.3	-0.5	0.4	-2.0	0.6	-1.1	0.8	0.4	-0.4	0.7
Number of live births	2.4	3.4	12.2	-3.5	1.4	-1.7	1.8	-1.4	0.3	-1.6	-1.5	-1.4	-2.3
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	4.1	0.8	1.2	0.1	-1.8	-0.2	2.0	0.1	-0.2	-0.6	0.5
Pulse rate	1.0	1.8	9.3	-0.4	-1.4	0.2	3.0	0.1	-1.9	0.9	0.7	1.0	0.4
Happiness	1.0	1.2	3.0	0.0	-1.2	1.4	1.5	1.0	0.3	0.8	0.3	1.4	1.7
Noisy workplace	1.5	1.8	10.6	3.3	-2.5	0.7	0.0	-0.0	-0.2	-0.3	-0.3	-0.3	0.8
Qualifications: A levels/AS levels or equivalent	1.5	3.4	8.7	1.6	-1.7	2.7	1.0	2.9	0.2	1.4	1.7	-1.4	2.0
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	8.9	-1.7	0.3	-0.3	3.0	0.0	0.8	0.6	0.5	0.6	0.4
Mouth/teeth dental problems: Dentures	0.8	1.4	5.2	-2.3	-1.0	-1.3	0.8	-1.1	-0.9	-0.4	-1.1	1.3	-0.9
Asthma	0.4	0.7	3.0	0.1	0.6	-0.7	-0.7	-0.4	0.3	-1.7	-0.6	-1.3	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	2.1	0.7	-1.4	0.8	0.1	0.5	0.2	0.7	0.8	0.4	0.1
Medication: Cholesterol lowering	0.4	0.6	3.0	0.8	-0.5	-0.1	-1.0	0.5	0.5	-0.4	-0.2	-1.7	-0.7
Depression (self-reported)	0.4	0.5	2.4	0.9	0.0	-0.9	0.2	-0.7	0.0	-0.1	-0.0	-0.5	-1.6
Medication: Lansoprazole	1.9	2.2	6.2	0.7	0.2	-2.5	1.4	-2.0	-0.5	-1.5	-1.2	0.5	-2.3
Prospective memory result	1.6	1.9	9.1	1.5	-3.0	1.0	-0.1	0.7	-1.6	1.0	0.7	0.8	1.4
Lung cancer (father)	0.7	0.8	2.5	0.4	-0.5	-0.9	-0.9	-1.2	-1.2	-0.4	-1.6	-0.1	0.1
Illnesses of mother	0.5	0.7	1.8	-1.4	-0.3	-0.7	0.8	-0.9	-0.6	-0.6	-0.8	-0.9	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	4.2	1.5	0.6	0.8	-1.1	0.4	2.0	0.8	0.5	0.4	1.0
Pulse wave Arterial Stiffness index	0.3	0.3	0.7	-0.1	0.5	-0.4	-0.8	-0.5	-0.7	-0.3	-0.8	0.0	-0.7
Impedance of arm (left)	0.8	3.5	10.4	0.4	1.5	-0.9	2.7	0.7	3.2	1.2	2.8	2.1	0.1
Arm fat mass (right)	0.2	0.8	2.7	-0.9	0.6	-0.3	0.9	-0.8	-1.6	-0.6	-1.4	-0.7	-0.5
Trunk predicted mass	0.8	4.5	14.5	-2.4	2.6	-1.0	-1.5	-2.6	-0.1	-1.8	-3.8	-1.8	-1.1
Standing height	0.9	9.2	29.4	-3.3	5.4	-2.8	0.2	-3.6	3.0	-2.5	-3.3	-0.4	-2.2
Length of working week for main job	1.2	1.3	5.1	0.2	0.1	1.6	-2.0	0.6	0.1	0.7	-0.4	0.2	2.3
Exposure to tobacco smoke at home	1.4	1.6	6.4	-1.6	0.6	-0.3	2.5	-0.3	-1.2	-1.5	-0.5	-1.1	-1.1
Breastfed as a baby	1.3	1.7	6.7	-0.2	1.5	-1.0	-0.0	-0.7	-0.4	-2.6	-1.1	-1.5	-1.6
Tense / ‘highly strung’	0.1	0.2	0.8	-0.1	0.8	0.1	0.9	0.5	0.3	0.5	0.5	-0.2	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	4.6	-0.4	-1.7	-1.2	0.8	-0.8	-1.1	-1.3	-0.4	-0.9	-2.1
Hair/balding pattern: Pattern 4	0.4	0.9	4.5	1.2	0.2	-0.0	1.6	0.2	0.1	0.4	0.6	2.1	-0.2
Birth weight of first child	0.7	1.3	4.6	-1.7	1.6	-0.3	1.4	-0.4	0.9	-0.1	-0.2	-2.1	0.2
Peak expiratory flow (PEF)	0.4	1.0	2.9	-0.1	1.7	0.4	-0.8	-0.3	1.4	-0.2	-1.4	-1.3	0.4
Pulse wave reflection index	0.5	0.6	3.8	0.4	0.3	0.6	-2.0	0.8	0.0	0.4	-0.6	-0.9	-0.1
Ever highly irritable/argumentative for 2 days	2.5	3.0	9.7	-3.1	1.9	-0.9	0.6	-1.3	0.6	-1.8	-2.0	-2.4	-0.9
Loud music exposure frequency	0.7	0.7	2.6	-1.6	1.6	-0.4	0.4	-0.2	0.3	0.2	0.4	-0.6	-1.1
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	4.9	0.5	-0.6	2.0	0.7	2.2	0.0	2.1	1.4	-1.3	1.7
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.3	-0.4	0.3	-0.2	1.1	-0.6	1.1	-0.1	-1.1	1.5	0.5
Blood clot in the leg (DVT)	0.6	0.8	3.8	0.1	0.5	-1.1	-0.7	-0.9	-0.8	0.8	0.1	2.0	-0.4
Medication: Paracetamol	0.6	1.0	2.3	1.0	-0.5	1.1	0.5	1.3	0.2	1.5	1.3	-0.4	1.3
Headache pain in last month	0.2	0.4	2.0	0.1	-0.7	-0.3	1.4	-0.5	0.0	-0.1	0.1	1.1	-0.0
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	4.9	0.2	-0.5	0.7	1.4	0.4	-0.3	1.0	0.7	2.2	1.3
Glaucoma (self-reported)	0.4	0.5	1.2	1.1	-1.1	0.8	0.6	0.1	-0.3	-0.9	-0.8	0.3	0.6
Gout (self-reported)	2.5	3.4	7.7	-1.3	1.3	-2.8	2.5	-2.4	0.7	-1.3	-1.8	1.2	-2.0
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	5.2	-1.8	1.3	-2.3	-0.3	-1.9	-0.9	-1.5	-1.9	0.6	-1.8
Medication: Amlodipine	0.1	0.2	0.4	-0.1	0.6	0.1	-0.6	-0.3	0.3	0.0	0.1	0.6	-0.6
Medication: Ventolin 100micrograms inhaler	0.6	0.7	3.0	0.6	-0.6	0.5	0.2	0.0	-1.7	-0.2	-0.3	-1.5	1.1
Birth weight	0.5	1.0	4.5	-2.1	1.6	-0.7	0.2	-0.2	1.3	0.6	-0.5	-0.2	-0.0
Chronic bronchitis/emphysema (mother)	0.8	1.0	5.6	0.3	0.5	0.6	1.3	1.1	2.4	-0.1	0.3	-0.8	0.1
High blood pressure (siblings)	0.3	0.4	1.1	0.5	0.1	0.1	-1.0	0.4	-1.1	-0.5	0.3	-1.1	-0.6
Forced vital capacity (FVC), Best measure	0.4	1.5	7.6	1.4	1.6	0.2	-1.6	-0.0	2.8	-0.2	0.1	0.4	0.4
Body fat percentage	0.2	0.7	3.6	-0.2	0.2	-0.5	1.4	-0.5	-1.9	-0.4	-0.4	0.1	-0.8
Leg fat percentage (right)	0.2	0.7	4.5	0.3	-0.9	0.0	-0.1	-0.0	-2.1	-0.5	-0.7	-0.7	-0.4
Arm fat-free mass (right)	0.6	2.9	8.3	-1.9	1.9	-0.4	-1.9	-1.7	-0.9	-1.4	-2.9	-1.7	-0.9
Exposure to tobacco smoke outside home	1.2	1.7	6.0	0.3	0.8	2.5	-0.2	1.8	1.6	0.4	0.3	0.1	1.9
Comparative body size at age 10	0.3	0.8	2.8	-0.2	-0.4	0.2	-1.7	-0.5	0.0	0.7	-1.1	1.6	0.4
Number of full brothers	2.9	3.6	8.9	-2.9	0.9	-2.0	2.8	-2.0	-0.3	0.2	-0.1	3.0	-1.4
Worry too long after embarrassment	0.5	0.9	3.0	-0.1	-1.7	0.9	0.5	1.3	-0.3	-0.2	1.3	0.7	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.4	0.6	-1.6	1.0	-0.5	0.9	-1.0	0.2	1.2	-1.3	-0.0
Wheeze or whistling in the chest in last year	0.5	0.9	3.9	-1.2	0.3	-0.1	0.2	-0.4	-0.1	-1.6	-0.5	-2.0	-0.7
Number of children fathered	0.3	0.4	1.3	-0.0	0.7	-1.1	0.5	-0.6	0.2	-0.1	-0.5	0.7	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	8.3	-2.9	2.1	-1.2	0.1	-1.2	-0.6	-1.3	-1.9	-0.0	-1.0
Age at first live birth	0.6	1.0	4.6	0.5	0.2	0.9	-0.1	-0.3	1.0	1.4	-0.4	2.1	1.2
Pulse wave peak to peak time	0.1	0.1	0.6	-0.1	-0.1	0.0	0.8	0.0	0.7	-0.2	0.3	-0.1	0.4
Health satisfaction	0.3	0.4	1.0	0.2	-0.7	0.6	0.8	1.0	-0.3	0.8	0.9	0.3	0.1
Shortness of breath walking on level ground	0.2	0.3	1.3	-0.1	0.2	0.6	0.3	0.7	0.7	0.1	-0.4	-1.1	0.2
Qualifications: College or University degree	0.3	1.0	2.8	1.3	-0.7	1.7	-0.1	1.4	1.1	0.6	1.0	-0.5	0.8
Eye problems/disorders: None of the above	0.8	0.9	4.4	-0.9	0.8	0.7	-2.1	0.4	0.7	-0.4	-0.9	-0.9	-0.3
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.6	0.4	-1.0	0.7	-0.6	-0.1	-0.8	-0.7	-1.0	-1.3	1.0
Emphysema/chronic bronchitis	2.4	2.7	5.7	0.4	-0.8	-1.7	0.9	-1.8	-1.7	-2.0	-0.9	-2.3	-2.4
Medication for pain relief, constipation, heartburn	0.3	0.5	1.0	-0.9	0.9	-0.9	-0.8	-0.4	0.2	-0.8	-0.4	-1.0	-0.5
Neck or shoulder pain in last month	0.1	0.2	0.6	-0.2	-0.7	0.3	0.0	0.2	-0.1	-0.4	0.0	-0.8	-0.3
Medication: Blood pressure	0.7	1.3	3.6	-1.5	1.9	-0.5	-0.7	-0.3	0.9	-1.0	-0.9	-1.6	-0.9
Angina (self-reported)	0.4	0.5	1.6	0.4	0.4	0.1	-0.9	-0.4	0.6	-1.0	-1.3	0.5	-0.8
Migraine (self-reported)	0.8	1.0	4.6	-0.6	0.1	-0.1	-1.2	0.3	-2.1	1.5	1.1	0.2	-0.3
Medication: Ibuprofen	0.4	0.5	1.1	-0.4	-1.1	0.8	-0.2	0.6	0.8	1.1	0.4	0.7	0.4
Medication: Allopurinol	1.6	2.2	3.4	-1.6	1.4	-1.8	1.1	-1.6	1.8	-1.4	-1.3	0.6	-1.7
Medication: Omeprazole	1.0	1.2	3.5	-1.3	0.9	0.8	0.7	0.5	1.1	1.0	0.8	1.9	1.2
Medication: Seretide 50 evohaler	0.4	0.5	1.6	-0.5	0.3	-0.9	0.0	-0.9	-0.7	-0.7	0.3	-0.2	-1.3
Mean time to correctly identify matches	1.5	2.8	11.9	-1.4	-0.1	-1.3	3.5	-1.5	-0.6	-2.5	-1.1	-1.0	-1.4
Heart disease (mother)	0.8	1.0	5.1	-0.6	-0.1	-0.1	-1.4	-0.7	-0.9	-0.4	-1.2	2.3	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	2.0	-0.0	-1.3	0.0	0.9	-0.4	-1.4	0.3	0.5	0.5	-0.3
Whole body fat mass	0.3	1.4	2.6	-1.1	1.3	-0.9	1.1	-1.3	-1.4	-1.1	-1.6	-0.8	-1.1
Leg fat mass (right)	0.3	1.2	3.8	-0.9	0.3	-0.5	0.1	-0.8	-1.9	-1.1	-1.5	-1.1	-0.9
Arm predicted mass (right)	0.6	3.0	8.7	-2.0	1.8	-0.4	-1.8	-1.8	-1.0	-1.5	-3.0	-1.8	-1.0
Pulse rate, automated reading	0.8	2.5	7.2	-0.5	-1.9	-0.9	2.3	-1.2	-2.7	0.1	0.2	2.5	0.1
Alcohol intake frequency.	0.7	1.7	10.3	0.3	-1.5	-0.4	1.4	-0.2	-3.2	1.1	0.7	0.6	0.1
Comparative height size at age 10	0.6	3.0	12.3	-1.7	3.5	-1.8	-0.3	-2.0	2.0	-1.0	-1.1	0.2	-1.3
Number of full sisters	0.7	0.9	2.8	-0.7	-1.5	-0.1	1.0	-0.6	-0.5	-0.6	-1.2	-1.7	-0.5
Suffer from ‘nerves’	0.1	0.2	0.7	-0.0	-0.4	-0.9	0.5	-0.4	-0.5	-0.3	0.1	-0.2	-0.7
Overall health rating	0.4	0.9	2.7	-0.9	0.3	-1.2	-0.3	-0.9	0.7	-1.4	-0.6	-0.8	-1.6
Chest pain or discomfort	0.5	0.7	2.5	-0.1	0.1	0.1	-1.0	-0.7	-0.4	-1.2	-1.3	-1.6	-0.3
Had major operations	0.6	0.7	3.7	-0.1	0.4	0.5	-0.4	1.1	1.1	-0.0	0.6	1.9	0.4
Age at last live birth	0.2	0.4	1.3	-0.6	0.4	0.5	-0.2	-0.5	0.6	0.6	-0.7	1.1	0.2
Family relationship satisfaction	1.8	2.3	8.3	0.8	-1.0	2.9	-0.3	2.2	0.2	0.6	1.1	-1.6	1.9
Leg pain on walking	0.1	0.1	0.3	0.3	-0.1	0.0	-0.4	0.0	-0.5	0.4	-0.4	-0.4	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.1	-0.4	0.4	0.4	0.2	-0.7	-0.5	-0.1	-1.1	0.9	0.6
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.4	0.2	0.6	0.1	-1.5	1.0	1.2	-0.4	0.7	-1.3	-0.6
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	6.3	1.1	0.2	0.6	-2.5	0.7	-1.6	-0.2	0.3	-1.1	0.0
Medication: Aspirin	0.6	0.7	2.6	-0.9	-0.5	0.3	-0.5	-1.0	-1.6	-0.3	-1.1	0.7	-0.7
Supplements: Vitamin C	0.4	0.5	3.3	-1.8	-0.1	-0.9	0.1	-0.8	0.1	0.2	-0.2	0.3	-0.4
Knee pain experienced in last month	1.4	2.1	3.9	1.6	-2.0	1.9	-1.5	1.3	-0.9	1.6	1.3	0.5	1.4
Hypertension (Self-reported)	0.8	2.1	5.1	-1.5	2.3	-1.0	-2.2	-0.8	-0.6	-1.7	-1.7	-0.9	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.6	3.0	-1.1	1.7	-1.5	0.8	-1.4	1.7	-1.0	-1.3	0.9	-0.4
Illnesses of father: Heart disease	0.2	0.3	1.7	0.2	-0.5	-0.4	-0.8	-0.6	-0.1	0.1	0.3	1.3	-0.1
Illnesses of siblings: Diabetes	1.8	2.2	5.0	2.1	-1.7	-0.8	-0.4	0.1	-2.2	-0.4	1.7	-0.9	-2.2
Smoking status: Previous	0.4	0.6	1.9	-0.6	0.7	0.8	-0.4	0.5	-0.2	-0.7	-0.5	-1.4	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	6.6	0.1	1.3	0.4	0.8	-0.2	2.6	-0.3	-1.3	0.2	0.5
Whole body fat-free mass	0.6	3.2	10.5	-2.2	2.4	-0.5	-1.2	-1.9	-0.1	-1.5	-3.2	-1.7	-0.7
Leg fat-free mass (right)	0.3	1.6	4.7	-1.9	2.0	0.2	-0.7	-1.1	-0.0	-0.7	-2.2	-1.2	-0.1
Arm fat percentage (left)	0.1	0.6	3.1	0.2	-0.7	0.1	1.4	0.1	-1.8	0.3	0.2	0.1	-0.1
Average weekly red wine intake	0.4	0.6	2.5	0.5	0.7	0.1	-0.5	0.5	-0.8	-0.0	1.1	-1.6	-0.8
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.2	0.6	0.0	-0.8	1.1	-0.7	0.8	-0.3	-0.5	1.0	-1.0
Mood swings	2.4	4.4	8.2	0.3	-2.9	2.7	-0.5	2.2	-1.1	2.9	2.7	0.9	2.3
Loneliness, isolation	0.5	0.7	3.0	0.4	-1.7	0.2	-0.1	0.5	-0.4	1.3	1.3	-0.1	0.6
Long-standing illness, disability or infirmity	0.7	1.1	2.9	-0.1	0.1	-0.8	-0.8	-1.2	-1.7	-1.2	-1.1	-0.9	-1.2
Ever had bowel cancer screening	2.8	3.3	8.9	-0.9	1.5	-2.5	0.5	-1.8	-0.4	-2.8	-1.4	-1.0	-3.0
Diabetes diagnosed by doctor	0.9	1.5	4.4	1.5	-1.5	0.6	0.2	0.6	-2.0	-1.1	-0.1	-2.1	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	3.3	3.6	6.7	-2.4	2.6	-2.0	2.6	-1.9	1.0	-0.6	-0.8	2.2	-1.4
Friendships satisfaction	3.2	3.9	8.1	2.0	-1.3	2.7	-0.2	2.8	1.3	1.7	2.5	0.8	2.6
Qualifications: nursing, teaching	0.5	0.8	1.9	1.0	-0.6	0.8	1.1	0.9	0.2	1.4	0.8	-0.3	1.3
Commuting to job workplace: Walk	0.5	0.5	2.1	-0.5	0.4	-0.5	0.3	-0.8	-0.4	0.8	-0.6	1.4	0.7
Eye problems/disorders: Cataract	0.6	0.7	3.3	0.6	0.0	-0.2	1.8	0.1	0.6	1.1	0.9	1.0	0.6
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	4.9	1.9	-1.5	0.7	0.1	1.2	0.4	1.1	1.5	0.8	2.2
Medication for cholesterol	0.7	1.1	3.2	1.0	-0.9	0.8	0.6	0.7	0.7	1.7	1.8	0.7	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	2.9	-1.5	1.2	-1.3	0.4	-1.5	0.2	-1.2	-1.7	1.0	-1.0
Back pain experienced in last month	0.4	0.5	2.4	0.8	-0.9	-0.2	-1.6	0.2	0.0	-0.5	0.6	0.4	-0.8
Mineral and other dietary supplements	0.5	0.7	3.0	-0.4	1.7	-0.2	1.7	0.0	0.4	0.2	-0.5	0.5	-0.0
Breast cancer (self-reported)	0.6	0.8	2.1	-0.8	0.7	0.9	0.4	1.4	1.4	0.2	1.1	0.3	0.6
Asthma (self-reported)	0.4	0.7	3.0	0.1	0.5	-0.7	-0.7	-0.2	0.2	-1.7	-0.3	-1.5	-0.8
Osteoporosis (self-reported)	0.4	0.5	1.4	-0.6	0.4	-1.1	1.2	-1.0	0.1	-0.3	-0.9	0.3	-0.3
Osteoarthritis (self-reported)	0.5	0.7	3.0	0.5	-0.9	-1.0	0.4	-1.0	-0.5	-0.0	-0.2	1.7	-0.6
Medication: Aspirin	0.6	0.8	1.9	-1.2	-0.6	0.0	-0.3	-1.1	-1.4	-0.0	-0.9	1.3	-0.8
Medication: Gliclazide	0.8	0.9	2.4	0.9	-1.1	0.5	1.3	0.4	-1.5	-0.3	0.2	-1.6	0.4
Illnesses of father: None of the above (group 1)	0.4	0.5	1.2	-1.0	0.9	-0.7	0.8	-0.9	-0.0	0.3	-1.1	0.5	-0.2
Smoking status: Current	0.7	1.1	2.8	-0.6	0.3	-1.6	0.1	-1.3	-0.2	-1.7	-1.0	-0.7	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	5.4	0.5	-0.6	1.6	-2.3	0.4	0.9	0.6	-0.4	-0.1	1.1
Whole body water mass	0.6	3.2	10.4	-2.3	2.3	-0.5	-1.3	-1.9	-0.2	-1.4	-3.2	-1.7	-0.7
Leg predicted mass (right)	0.3	1.6	4.9	-2.0	2.0	0.2	-0.6	-1.1	-0.1	-0.7	-2.2	-1.2	-0.1
Arm fat mass (left)	0.2	0.7	3.0	-0.8	0.3	-0.3	0.7	-0.7	-1.7	-0.6	-1.1	-0.5	-0.5
Number of self-reported non-cancer illnesses	1.8	3.1	6.3	-0.2	2.4	-1.1	-1.4	-1.3	-0.4	-2.5	-2.0	-2.4	-1.9
Average weekly champagne plus white wine intake	0.6	0.8	3.2	-1.1	0.8	0.2	0.4	0.1	0.5	1.4	0.7	1.8	0.0
Miserableness	0.9	1.5	4.2	0.4	-1.8	1.5	0.3	1.1	0.5	1.3	1.3	-0.8	2.0
Guilty feelings	1.3	2.0	3.4	1.8	-1.2	1.8	-0.1	1.6	-1.2	1.4	1.7	-1.0	1.5
Wears glasses or contact lenses	2.7	3.1	7.3	-2.1	-0.5	-2.1	1.2	-2.4	-1.2	-1.8	-2.7	1.0	-1.3
Ever taken oral contraceptive pill	1.0	1.2	2.6	0.1	-0.6	1.2	0.2	1.2	1.6	1.5	1.2	1.1	0.8
Hearing aid user	1.0	1.2	3.5	-1.0	1.5	-0.4	1.9	-0.5	1.6	-1.0	-0.6	-0.5	-0.5
Mother’s age at death	1.6	2.0	4.9	-1.5	0.5	-1.9	1.3	-2.2	-1.1	-0.8	-1.5	0.1	-1.6
Financial situation satisfaction	0.8	1.0	6.3	-1.1	-0.7	0.7	-0.2	0.6	-0.6	0.8	0.4	2.5	0.2
Tinnitus: Yes, now most or all of the time	1.2	1.3	6.2	-1.0	0.1	0.3	0.3	0.4	1.0	1.1	0.1	2.5	1.9
Commuting to job workplace: Public transport	0.4	0.5	1.3	0.1	-0.0	0.8	1.1	-0.3	-0.5	0.7	-0.5	0.6	1.1
Eye problems/disorders: Glaucoma	0.4	0.5	2.3	0.7	-0.4	0.7	0.5	-0.0	0.1	0.3	-0.1	1.5	1.0
Medication: Blood pressure	0.7	1.3	3.2	-0.8	1.2	-1.3	-0.2	-1.1	-1.2	-1.8	-1.6	-0.6	-1.0
Pain type(s) experienced in last month: Hip pain	1.7	2.1	5.3	-0.8	-0.5	-1.0	2.2	-1.5	-1.7	-1.7	-1.1	-0.5	-2.3
Supplements: Fish oil (including cod liver oil)	1.2	1.5	8.6	0.7	-1.1	0.9	-2.9	1.0	-0.8	0.3	1.2	-0.4	0.8
High cholesterol (Self-reported)	0.7	1.2	5.0	2.2	-0.3	0.9	-1.2	0.5	1.6	-0.4	0.3	-0.7	-1.2
Medication: Bendroflumethiazide	0.4	0.6	2.2	-0.6	-0.4	-0.3	0.4	-0.5	-1.5	-0.6	-1.2	0.9	-0.1
Medication: Paracetamol	0.8	1.3	3.6	0.3	-0.4	1.2	1.1	1.1	0.9	1.8	1.1	0.1	1.9
Medication: Lisinopril	0.3	0.4	1.2	0.5	1.0	0.3	-0.7	0.7	1.1	0.5	0.5	0.5	-0.4
Medication: Atorvastatin	0.9	1.1	3.0	1.4	-1.1	1.4	0.4	1.5	-0.1	-0.0	0.6	-1.7	0.4
Illnesses of father: High blood pressure	0.8	1.0	2.4	0.2	-0.5	1.1	-1.5	1.4	-0.6	0.7	1.2	-1.4	0.3
Alcohol drinker status: Never	0.8	1.0	4.2	-1.1	1.1	0.2	-2.0	0.4	-0.5	-1.5	-0.8	-0.0	0.3
Ever smoked	0.5	0.9	3.4	-0.5	0.9	0.0	0.3	0.1	0.7	-1.1	-1.2	-1.8	-0.9
Basal metabolic rate	0.5	2.7	8.7	-2.1	2.2	-0.6	-0.9	-1.8	-0.3	-1.3	-3.0	-1.6	-0.7
Leg fat percentage (left)	0.3	1.1	7.5	0.5	-0.8	0.3	0.1	0.1	-2.7	-0.6	-0.8	-1.0	-0.5
Arm fat-free mass (left)	0.7	3.4	11.4	-2.1	2.1	-0.7	-1.5	-2.1	-0.8	-1.7	-3.4	-1.5	-0.8
Number of operations (self-reported)	2.3	3.3	11.8	-3.4	2.8	-1.8	1.3	-1.2	-0.5	-0.9	-1.1	1.3	-1.9
Average weekly beer plus cider intake	0.4	0.6	2.0	-0.3	0.9	0.3	0.2	-0.4	0.1	-1.1	-1.4	-1.1	0.1
Irritability	0.7	1.2	3.3	-0.4	-1.2	1.3	0.7	0.8	-1.1	1.8	1.5	-0.0	0.4
Risk taking	2.0	2.9	5.3	2.2	-0.9	2.1	-1.0	2.2	1.1	0.9	2.0	-2.3	1.1
Ever had prostate specific antigen (PSA) test	1.1	1.3	3.0	-1.4	-0.1	-1.5	-1.7	-1.6	-1.5	0.1	-0.5	0.5	-0.8
Fractured/broken bones in last 5 years	2.3	3.0	7.3	-2.0	1.4	-2.2	1.7	-2.7	0.3	-1.0	-1.5	1.2	-2.0
Age started oral contraceptive pill	0.9	1.1	3.0	-1.7	1.6	-1.5	0.8	-1.1	-0.1	0.1	-0.2	0.2	-1.1
Diastolic blood pressure, automated reading	0.2	0.7	2.6	-0.3	-0.4	-0.1	-0.1	0.1	-1.6	-1.5	-1.3	0.2	-0.1
Ever depressed for a whole week	0.4	0.5	1.3	-1.2	-0.1	0.6	-0.3	-0.1	-1.1	0.9	0.2	1.1	0.1
Unable to work because of sickness or disability	0.8	1.1	5.1	0.9	-0.4	-0.1	0.1	0.2	-1.2	-0.8	0.8	-2.3	-1.3
Commuting to job workplace: Cycle	0.5	0.6	1.3	-0.9	0.7	-0.5	0.6	-1.1	0.8	-0.0	-1.0	1.2	-0.4
Myopia	1.6	2.3	5.0	-2.2	1.0	-0.9	2.0	-1.2	1.0	-2.2	-2.0	-0.4	-0.4
Vascular/heart problems diagnosed by doctor	0.7	1.9	4.5	1.2	-2.0	0.6	1.8	0.8	0.5	1.8	2.1	0.8	0.9
Cholesterol lowering medication	0.2	0.3	0.9	0.8	-0.3	0.7	-0.3	0.1	0.2	-0.2	-0.1	0.6	-1.0
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	2.9	-0.8	0.4	1.5	1.0	1.1	1.3	1.1	1.3	1.7	1.5
Pain experienced in last month	0.4	0.6	1.5	-0.5	0.9	-0.8	-0.6	-1.1	-1.1	-0.2	-1.2	-0.5	0.1
Supplements: Calcium	0.2	0.2	0.8	-0.3	-0.9	0.2	0.8	-0.4	-0.0	0.5	-0.6	0.0	-0.2
Basal cell carcinoma (self-reported)	0.9	1.0	3.6	-1.4	0.7	-1.1	-0.1	-1.4	0.1	-0.3	-1.0	1.9	-0.5
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.5	-0.9	0.5	-0.7	1.2	-0.4	0.0	0.2	-0.6	-0.1	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.7	-0.1	0.7	-1.4	-0.5	-1.1	-0.8	0.6	0.0	1.6	-0.7
Heart disease (siblings)	0.8	1.0	4.5	1.2	-1.3	0.7	-2.1	-0.1	-1.1	0.3	0.1	0.5	-0.1
Alcohol drinker status: Previous	1.1	1.2	4.6	0.9	-1.5	0.2	-0.1	0.5	-2.2	1.2	1.7	0.2	0.1
Pack years of smoking	1.3	1.9	6.4	-0.8	1.0	-1.8	2.5	-1.7	-0.6	-1.2	-1.2	0.9	-0.8
Impedance of whole body	0.4	2.0	6.3	0.6	1.3	-1.2	1.9	0.2	2.5	0.5	2.0	1.4	-0.5
Leg fat mass (left)	0.4	1.4	5.7	-0.9	0.3	-0.4	0.2	-0.8	-2.4	-1.3	-1.6	-1.3	-1.0
Arm predicted mass (left)	0.7	3.7	11.0	-2.0	2.2	-0.7	-1.7	-2.1	-1.1	-1.8	-3.3	-1.9	-1.1