TWAS hub - SYNGR2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Liver	0.3450	0.1200	5.6e-03	0.029	NA	0.124	NA	0.058	5.3e-02	NA	2.6e-04	NA	1.0e-02
2	GTEx	Nerve Tibial	0.1630	0.0554	3.4e-03	0.046	NA	0.051	NA	0.044	3.4e-04	NA	1.7e-04	NA	4.6e-04
3	GTEx	Pituitary	0.5830	0.1260	7.3e-04	0.074	NA	0.030	NA	0.067	6.6e-03	NA	6.1e-02	NA	9.2e-03
4	GTEx	Vagina	0.5740	0.1380	5.0e-03	0.002	NA	0.002	NA	-0.012	2.8e-01	NA	2.8e-01	NA	7.7e-01
5	TCGA	Breast Invasive Carcinoma	0.0470	0.0180	9.9e-06	0.011	0.020	0.019	NA	0.024	1.7e-03	3.9e-05	7.4e-05	NA	9.8e-06
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0945	0.0356	6.7e-04	0.001	0.018	0.013	NA	-0.002	2.4e-01	3.8e-03	1.1e-02	NA	6.4e-01
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0899	0.0336	2.0e-05	0.068	0.052	0.060	NA	0.055	3.8e-08	1.7e-06	2.6e-07	NA	7.9e-07
8	TCGA	Lung Adenocarcinoma	0.0659	0.0228	1.7e-06	0.063	0.056	0.064	NA	0.061	6.5e-08	4.2e-07	6.2e-08	NA	1.2e-07
9	TCGA	Skin Cutaneous Melanoma	0.5170	0.0920	1.1e-04	-0.006	0.078	0.011	NA	-0.007	4.9e-01	4.1e-03	1.6e-01	NA	5.4e-01
10	TCGA	Thyroid Carcinoma	0.1350	0.0370	4.5e-11	0.079	0.130	0.128	NA	0.123	3.6e-08	1.3e-12	2.1e-12	NA	5.1e-12

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Ever had stillbirth, spontaneous miscarriage or termination	3.3	3.6	6.7	-2.4	2.6	-2.0	2.6	-1.9	1.0	-0.6	-0.8	2.2	-1.4
Friendships satisfaction	3.2	3.9	8.1	2.0	-1.3	2.7	-0.2	2.8	1.3	1.7	2.5	0.8	2.6
Number of full brothers	2.9	3.6	8.9	-2.9	0.9	-2.0	2.8	-2.0	-0.3	0.2	-0.1	3.0	-1.4
Ever had bowel cancer screening	2.8	3.3	8.9	-0.9	1.5	-2.5	0.5	-1.8	-0.4	-2.8	-1.4	-1.0	-3.0
Wears glasses or contact lenses	2.7	3.1	7.3	-2.1	-0.5	-2.1	1.2	-2.4	-1.2	-1.8	-2.7	1.0	-1.3
Ever highly irritable/argumentative for 2 days	2.5	3.0	9.7	-3.1	1.9	-0.9	0.6	-1.3	0.6	-1.8	-2.0	-2.4	-0.9
Gout (self-reported)	2.5	3.4	7.7	-1.3	1.3	-2.8	2.5	-2.4	0.7	-1.3	-1.8	1.2	-2.0
High blood pressure (mother)	2.4	3.4	9.2	2.5	-1.0	2.9	-0.1	2.6	0.3	1.1	1.2	-0.0	3.0
Number of live births	2.4	3.4	12.2	-3.5	1.4	-1.7	1.8	-1.4	0.3	-1.6	-1.5	-1.4	-2.3
Emphysema/chronic bronchitis	2.4	2.7	5.7	0.4	-0.8	-1.7	0.9	-1.8	-1.7	-2.0	-0.9	-2.3	-2.4
Mood swings	2.4	4.4	8.2	0.3	-2.9	2.7	-0.5	2.2	-1.1	2.9	2.7	0.9	2.3
Multivitamins +/- minerals	2.3	2.9	11.3	1.4	-1.4	3.4	-1.5	2.2	0.3	1.0	1.4	-0.0	2.1
Number of operations (self-reported)	2.3	3.3	11.8	-3.4	2.8	-1.8	1.3	-1.2	-0.5	-0.9	-1.1	1.3	-1.9
Fractured/broken bones in last 5 years	2.3	3.0	7.3	-2.0	1.4	-2.2	1.7	-2.7	0.3	-1.0	-1.5	1.2	-2.0
Ever used hormone-replacement therapy (HRT)	2.2	2.8	8.9	-3.0	0.5	-1.4	-1.3	-1.3	-1.5	-1.7	-2.1	-0.2	-1.9
HbA1C	2.1	2.3	6.5	0.1	-0.8	2.5	1.5	1.4	-0.1	1.4	0.3	2.0	2.4
Risk taking	2.0	2.9	5.3	2.2	-0.9	2.1	-1.0	2.2	1.1	0.9	2.0	-2.3	1.1
Prostate Cancer	1.9	2.7	4.6	-1.7	1.8	-1.6	0.9	-1.8	1.3	-1.7	-2.1	2.0	-0.9
Medication: Lansoprazole	1.9	2.2	6.2	0.7	0.2	-2.5	1.4	-2.0	-0.5	-1.5	-1.2	0.5	-2.3
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	8.3	-2.9	2.1	-1.2	0.1	-1.2	-0.6	-1.3	-1.9	-0.0	-1.0
Taking other prescription medications	1.8	2.7	10.2	-1.2	0.0	-2.2	1.2	-2.0	-2.0	-0.8	-0.8	0.2	-3.2
Medication: Atenolol	1.8	2.2	8.4	-1.3	1.4	-0.8	-1.1	-1.4	0.2	-2.3	-2.9	-0.8	-0.6
Family relationship satisfaction	1.8	2.3	8.3	0.8	-1.0	2.9	-0.3	2.2	0.2	0.6	1.1	-1.6	1.9
Illnesses of siblings: Diabetes	1.8	2.2	5.0	2.1	-1.7	-0.8	-0.4	0.1	-2.2	-0.4	1.7	-0.9	-2.2
Number of self-reported non-cancer illnesses	1.8	3.1	6.3	-0.2	2.4	-1.1	-1.4	-1.3	-0.4	-2.5	-2.0	-2.4	-1.9
Chronotype (morning person)	1.7	4.0	9.0	1.7	-3.0	1.3	2.1	2.8	-0.6	1.3	2.7	-2.2	0.0
Pain type(s) experienced in last month: Hip pain	1.7	2.1	5.3	-0.8	-0.5	-1.0	2.2	-1.5	-1.7	-1.7	-1.1	-0.5	-2.3
Blood Red Count	1.6	15.4	72.6	-3.8	4.4	-0.4	-3.5	-1.5	-0.8	-2.3	-5.1	8.5	0.9
Prospective memory result	1.6	1.9	9.1	1.5	-3.0	1.0	-0.1	0.7	-1.6	1.0	0.7	0.8	1.4
Medication: Allopurinol	1.6	2.2	3.4	-1.6	1.4	-1.8	1.1	-1.6	1.8	-1.4	-1.3	0.6	-1.7
Mother’s age at death	1.6	2.0	4.9	-1.5	0.5	-1.9	1.3	-2.2	-1.1	-0.8	-1.5	0.1	-1.6
Myopia	1.6	2.3	5.0	-2.2	1.0	-0.9	2.0	-1.2	1.0	-2.2	-2.0	-0.4	-0.4
Diabetes (father)	1.5	1.9	5.9	1.7	-1.6	1.5	-0.1	1.1	-1.4	1.0	1.0	-2.4	0.1
Noisy workplace	1.5	1.8	10.6	3.3	-2.5	0.7	0.0	-0.0	-0.2	-0.3	-0.3	-0.3	0.8
Qualifications: A levels/AS levels or equivalent	1.5	3.4	8.7	1.6	-1.7	2.7	1.0	2.9	0.2	1.4	1.7	-1.4	2.0
Mean time to correctly identify matches	1.5	2.8	11.9	-1.4	-0.1	-1.3	3.5	-1.5	-0.6	-2.5	-1.1	-1.0	-1.4
Type 2 Diabetes (T2D) (2018)	1.4	2.7	8.7	2.9	-1.7	2.0	-0.6	1.6	-2.0	0.2	1.4	-1.2	0.5
Medication: Ramipril	1.4	1.8	8.5	-2.9	1.8	-0.8	-0.3	-0.7	0.1	-0.9	-1.4	-1.0	-1.1
Exposure to tobacco smoke at home	1.4	1.6	6.4	-1.6	0.6	-0.3	2.5	-0.3	-1.2	-1.5	-0.5	-1.1	-1.1
Knee pain experienced in last month	1.4	2.1	3.9	1.6	-2.0	1.9	-1.5	1.3	-0.9	1.6	1.3	0.5	1.4
Alzheimer’s Disease (in father)	1.3	1.4	3.3	0.3	-0.8	1.4	0.3	1.5	-0.3	1.5	1.8	-1.2	1.2
Breastfed as a baby	1.3	1.7	6.7	-0.2	1.5	-1.0	-0.0	-0.7	-0.4	-2.6	-1.1	-1.5	-1.6
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	4.9	0.5	-0.6	2.0	0.7	2.2	0.0	2.1	1.4	-1.3	1.7
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	5.2	-1.8	1.3	-2.3	-0.3	-1.9	-0.9	-1.5	-1.9	0.6	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.6	3.0	-1.1	1.7	-1.5	0.8	-1.4	1.7	-1.0	-1.3	0.9	-0.4
Guilty feelings	1.3	2.0	3.4	1.8	-1.2	1.8	-0.1	1.6	-1.2	1.4	1.7	-1.0	1.5
Pack years of smoking	1.3	1.9	6.4	-0.8	1.0	-1.8	2.5	-1.7	-0.6	-1.2	-1.2	0.9	-0.8
Height	1.2	22.5	69.4	-4.8	8.3	-5.3	1.6	-5.6	3.5	-4.3	-4.8	-0.8	-4.0
Smoking Status	1.2	2.8	6.5	-1.7	2.0	-1.4	-1.1	-1.4	0.3	-2.6	-1.9	-1.4	-2.0
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	8.9	-1.7	0.3	-0.3	3.0	0.0	0.8	0.6	0.5	0.6	0.4
Length of working week for main job	1.2	1.3	5.1	0.2	0.1	1.6	-2.0	0.6	0.1	0.7	-0.4	0.2	2.3
Exposure to tobacco smoke outside home	1.2	1.7	6.0	0.3	0.8	2.5	-0.2	1.8	1.6	0.4	0.3	0.1	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	2.9	-1.5	1.2	-1.3	0.4	-1.5	0.2	-1.2	-1.7	1.0	-1.0
Tinnitus: Yes, now most or all of the time	1.2	1.3	6.2	-1.0	0.1	0.3	0.3	0.4	1.0	1.1	0.1	2.5	1.9
Supplements: Fish oil (including cod liver oil)	1.2	1.5	8.6	0.7	-1.1	0.9	-2.9	1.0	-0.8	0.3	1.2	-0.4	0.8
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	2.9	-0.8	0.4	1.5	1.0	1.1	1.3	1.1	1.3	1.7	1.5
Bipolar Disorder (2018)	1.1	1.7	5.4	0.4	-0.7	1.9	-0.9	1.5	-0.5	0.8	0.7	2.3	1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	4.6	0.2	-1.7	1.5	-0.7	1.0	-0.3	1.3	1.0	0.1	2.1
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	4.9	1.9	-1.5	0.7	0.1	1.2	0.4	1.1	1.5	0.8	2.2
Ever had prostate specific antigen (PSA) test	1.1	1.3	3.0	-1.4	-0.1	-1.5	-1.7	-1.6	-1.5	0.1	-0.5	0.5	-0.8
Alcohol drinker status: Previous	1.1	1.2	4.6	0.9	-1.5	0.2	-0.1	0.5	-2.2	1.2	1.7	0.2	0.1
Medication for hormone replacement therapy	1.0	1.1	4.2	-1.8	0.7	-0.2	-0.6	-0.2	-0.5	-1.1	-2.0	-0.9	-0.4
Pack years adult smoking proportion	1.0	1.5	4.8	-0.6	1.2	-1.7	2.2	-1.5	-0.6	-1.0	-0.9	0.8	-0.8
Pulse rate	1.0	1.8	9.3	-0.4	-1.4	0.2	3.0	0.1	-1.9	0.9	0.7	1.0	0.4
Happiness	1.0	1.2	3.0	0.0	-1.2	1.4	1.5	1.0	0.3	0.8	0.3	1.4	1.7
Medication: Omeprazole	1.0	1.2	3.5	-1.3	0.9	0.8	0.7	0.5	1.1	1.0	0.8	1.9	1.2
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	6.3	1.1	0.2	0.6	-2.5	0.7	-1.6	-0.2	0.3	-1.1	0.0
Ever taken oral contraceptive pill	1.0	1.2	2.6	0.1	-0.6	1.2	0.2	1.2	1.6	1.5	1.2	1.1	0.8
Hearing aid user	1.0	1.2	3.5	-1.0	1.5	-0.4	1.9	-0.5	1.6	-1.0	-0.6	-0.5	-0.5
Irritable Bowel Disease (IBD)	0.9	2.1	4.2	-0.3	0.9	1.6	-1.0	1.6	1.9	2.0	1.8	0.6	1.6
Diabetes (mother)	0.9	1.1	2.7	-1.2	-0.3	-1.5	0.9	-1.5	-1.6	-0.3	-0.6	-0.3	-1.2
Average weekly fortified wine intake	0.9	1.0	3.8	-0.0	-0.1	-0.8	0.9	-1.8	0.7	-0.8	-1.9	0.6	-0.1
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	3.0	-0.4	1.0	1.3	1.3	1.2	0.4	0.5	0.5	-1.0	1.7
Medication: Levothyroxine sodium	0.9	1.5	3.4	-0.7	0.5	-1.5	-0.0	-1.5	-1.8	-1.3	-1.4	-0.0	-1.5
Had other major operations	0.9	1.1	5.7	-1.7	1.0	-0.3	2.4	0.4	0.1	0.7	0.5	0.5	-0.7
Time employed in main current job	0.9	1.1	4.0	0.3	0.2	-1.4	-0.3	-1.1	-0.3	-2.0	-0.4	-0.8	-1.6
Standing height	0.9	9.2	29.4	-3.3	5.4	-2.8	0.2	-3.6	3.0	-2.5	-3.3	-0.4	-2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	4.6	-0.4	-1.7	-1.2	0.8	-0.8	-1.1	-1.3	-0.4	-0.9	-2.1
Diabetes diagnosed by doctor	0.9	1.5	4.4	1.5	-1.5	0.6	0.2	0.6	-2.0	-1.1	-0.1	-2.1	-0.5
Miserableness	0.9	1.5	4.2	0.4	-1.8	1.5	0.3	1.1	0.5	1.3	1.3	-0.8	2.0
Medication: Atorvastatin	0.9	1.1	3.0	1.4	-1.1	1.4	0.4	1.5	-0.1	-0.0	0.6	-1.7	0.4
Age started oral contraceptive pill	0.9	1.1	3.0	-1.7	1.6	-1.5	0.8	-1.1	-0.1	0.1	-0.2	0.2	-1.1
Basal cell carcinoma (self-reported)	0.9	1.0	3.6	-1.4	0.7	-1.1	-0.1	-1.4	0.1	-0.3	-1.0	1.9	-0.5
Depressed Affect (Nagel 2018)	0.8	1.6	4.4	-0.3	-1.0	1.2	-0.8	0.7	0.9	1.8	1.6	1.1	2.1
Depression (Nagel 2018)	0.8	1.2	3.8	-0.3	-2.0	1.1	-1.1	0.2	-0.7	0.9	0.2	0.7	1.9
Neuroticism (Nagel 2018)	0.8	1.9	3.6	0.2	-1.0	1.4	-0.7	1.0	0.5	1.9	1.9	1.8	1.9
Schizophrenia vs Biploar Disorder	0.8	1.1	4.2	-1.6	0.9	-0.5	-0.2	-0.4	0.4	-1.3	-1.1	-2.1	-0.2
Allergy or Eczema	0.8	2.2	6.7	2.6	-1.2	1.2	-1.3	1.5	0.2	0.7	2.0	-1.9	-0.3
Medication: Co-codamol	0.8	0.9	3.1	0.1	0.8	-1.4	0.0	-1.2	0.2	-1.1	-0.5	-0.6	-1.8
Waist circumference	0.8	3.0	6.8	-1.8	1.1	-1.5	1.0	-2.0	-2.0	-1.9	-2.6	-0.8	-1.8
Medication: Simvastatin	0.8	1.2	3.1	0.5	0.9	-0.4	-1.4	-1.0	0.0	-1.4	-1.5	-0.8	-1.8
Mouth/teeth dental problems: Dentures	0.8	1.4	5.2	-2.3	-1.0	-1.3	0.8	-1.1	-0.9	-0.4	-1.1	1.3	-0.9
Impedance of arm (left)	0.8	3.5	10.4	0.4	1.5	-0.9	2.7	0.7	3.2	1.2	2.8	2.1	0.1
Trunk predicted mass	0.8	4.5	14.5	-2.4	2.6	-1.0	-1.5	-2.6	-0.1	-1.8	-3.8	-1.8	-1.1
Chronic bronchitis/emphysema (mother)	0.8	1.0	5.6	0.3	0.5	0.6	1.3	1.1	2.4	-0.1	0.3	-0.8	0.1
Eye problems/disorders: None of the above	0.8	0.9	4.4	-0.9	0.8	0.7	-2.1	0.4	0.7	-0.4	-0.9	-0.9	-0.3
Migraine (self-reported)	0.8	1.0	4.6	-0.6	0.1	-0.1	-1.2	0.3	-2.1	1.5	1.1	0.2	-0.3
Heart disease (mother)	0.8	1.0	5.1	-0.6	-0.1	-0.1	-1.4	-0.7	-0.9	-0.4	-1.2	2.3	-0.0
Pulse rate, automated reading	0.8	2.5	7.2	-0.5	-1.9	-0.9	2.3	-1.2	-2.7	0.1	0.2	2.5	0.1
Hypertension (Self-reported)	0.8	2.1	5.1	-1.5	2.3	-1.0	-2.2	-0.8	-0.6	-1.7	-1.7	-0.9	-0.8
Medication: Gliclazide	0.8	0.9	2.4	0.9	-1.1	0.5	1.3	0.4	-1.5	-0.3	0.2	-1.6	0.4
Financial situation satisfaction	0.8	1.0	6.3	-1.1	-0.7	0.7	-0.2	0.6	-0.6	0.8	0.4	2.5	0.2
Medication: Paracetamol	0.8	1.3	3.6	0.3	-0.4	1.2	1.1	1.1	0.9	1.8	1.1	0.1	1.9
Illnesses of father: High blood pressure	0.8	1.0	2.4	0.2	-0.5	1.1	-1.5	1.4	-0.6	0.7	1.2	-1.4	0.3
Alcohol drinker status: Never	0.8	1.0	4.2	-1.1	1.1	0.2	-2.0	0.4	-0.5	-1.5	-0.8	-0.0	0.3
Unable to work because of sickness or disability	0.8	1.1	5.1	0.9	-0.4	-0.1	0.1	0.2	-1.2	-0.8	0.8	-2.3	-1.3
Heart disease (siblings)	0.8	1.0	4.5	1.2	-1.3	0.7	-2.1	-0.1	-1.1	0.3	0.1	0.5	-0.1
Crohns Disease (2017)	0.7	1.5	3.4	0.7	0.1	1.6	0.1	1.4	1.5	1.7	1.8	0.1	1.3
Rheumatoid Arthritis	0.7	0.9	3.6	0.9	-1.9	1.0	-0.7	0.8	-0.5	0.8	0.7	-0.9	0.6
Waist Hip Ratio (WHR)	0.7	3.0	6.5	-1.6	2.3	-1.7	1.4	-2.5	-0.2	-1.3	-2.1	-0.2	-2.2
Hand grip strength (left)	0.7	1.9	5.2	-1.2	2.2	-1.2	-2.3	-1.4	0.2	0.6	-1.4	1.3	-0.4
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.7	0.2	-1.6	0.8	-1.4	-0.0	-1.6	-0.2	-0.1	-1.2	1.0
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.6	0.9	-0.7	0.5	1.6	-0.0	1.1	1.3	0.4	1.4	0.3
Medication: Metformin	0.7	0.9	2.6	1.6	-0.9	0.3	-0.8	0.5	-1.6	-0.9	-0.0	-1.2	-0.3
Townsend deprivation index at recruitment	0.7	1.0	5.4	0.0	0.0	0.2	0.3	-0.9	-1.1	-2.3	-1.4	-0.1	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	2.9	-1.4	1.1	-1.6	1.3	-1.7	-1.6	-0.9	-0.9	0.1	-1.3
High blood pressure	0.7	1.9	4.5	-1.6	2.1	-0.8	-1.8	-0.7	-0.8	-1.5	-1.6	-0.9	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	5.2	-1.5	0.5	-1.1	2.0	-1.3	-2.3	-0.3	-0.9	1.1	-0.4
Trunk fat-free mass	0.7	4.2	13.8	-2.4	2.5	-0.9	-1.4	-2.5	-0.0	-1.8	-3.7	-1.8	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	3.5	0.7	-1.7	0.5	-0.5	0.1	-1.3	1.3	1.9	0.3	0.1
Lung cancer (father)	0.7	0.8	2.5	0.4	-0.5	-0.9	-0.9	-1.2	-1.2	-0.4	-1.6	-0.1	0.1
Birth weight of first child	0.7	1.3	4.6	-1.7	1.6	-0.3	1.4	-0.4	0.9	-0.1	-0.2	-2.1	0.2
Loud music exposure frequency	0.7	0.7	2.6	-1.6	1.6	-0.4	0.4	-0.2	0.3	0.2	0.4	-0.6	-1.1
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	4.9	0.2	-0.5	0.7	1.4	0.4	-0.3	1.0	0.7	2.2	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.4	0.6	-1.6	1.0	-0.5	0.9	-1.0	0.2	1.2	-1.3	-0.0
Medication: Blood pressure	0.7	1.3	3.6	-1.5	1.9	-0.5	-0.7	-0.3	0.9	-1.0	-0.9	-1.6	-0.9
Alcohol intake frequency.	0.7	1.7	10.3	0.3	-1.5	-0.4	1.4	-0.2	-3.2	1.1	0.7	0.6	0.1
Number of full sisters	0.7	0.9	2.8	-0.7	-1.5	-0.1	1.0	-0.6	-0.5	-0.6	-1.2	-1.7	-0.5
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.4	0.2	0.6	0.1	-1.5	1.0	1.2	-0.4	0.7	-1.3	-0.6
Long-standing illness, disability or infirmity	0.7	1.1	2.9	-0.1	0.1	-0.8	-0.8	-1.2	-1.7	-1.2	-1.1	-0.9	-1.2
Medication for cholesterol	0.7	1.1	3.2	1.0	-0.9	0.8	0.6	0.7	0.7	1.7	1.8	0.7	1.0
Smoking status: Current	0.7	1.1	2.8	-0.6	0.3	-1.6	0.1	-1.3	-0.2	-1.7	-1.0	-0.7	-1.5
Medication: Blood pressure	0.7	1.3	3.2	-0.8	1.2	-1.3	-0.2	-1.1	-1.2	-1.8	-1.6	-0.6	-1.0
High cholesterol (Self-reported)	0.7	1.2	5.0	2.2	-0.3	0.9	-1.2	0.5	1.6	-0.4	0.3	-0.7	-1.2
Arm fat-free mass (left)	0.7	3.4	11.4	-2.1	2.1	-0.7	-1.5	-2.1	-0.8	-1.7	-3.4	-1.5	-0.8
Irritability	0.7	1.2	3.3	-0.4	-1.2	1.3	0.7	0.8	-1.1	1.8	1.5	-0.0	0.4
Vascular/heart problems diagnosed by doctor	0.7	1.9	4.5	1.2	-2.0	0.6	1.8	0.8	0.5	1.8	2.1	0.8	0.9
Arm predicted mass (left)	0.7	3.7	11.0	-2.0	2.2	-0.7	-1.7	-2.1	-1.1	-1.8	-3.3	-1.9	-1.1
Ulcerative Colitis (UC)	0.6	1.0	2.3	-0.9	1.3	0.6	-1.5	0.8	1.5	0.9	0.7	0.5	0.8
Reaction Time	0.6	1.1	7.7	-1.0	-0.8	-0.2	2.8	-0.3	0.2	-1.2	-0.1	-0.5	-0.1
Age at First Birth	0.6	0.8	2.4	-1.0	-0.3	-0.6	-1.5	-0.9	-1.2	-0.4	-1.4	0.0	0.2
Coronary Artery Disease (CAD)	0.6	0.7	5.0	1.4	0.2	0.7	-2.2	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.6	1.0	2.6	0.6	-0.5	1.6	0.3	1.6	1.2	0.7	1.0	0.1	0.9
Primary Biliary Cirrhosis	0.6	0.8	3.9	-2.0	0.5	-0.7	0.2	-1.1	-0.2	-0.3	-1.0	1.0	-0.3
Blood Platelet Count	0.6	6.4	26.8	5.2	-4.4	1.0	1.5	0.5	-0.4	-1.3	0.6	-3.5	-0.8
Cardiovascular Disease	0.6	1.9	4.9	-1.0	1.0	-0.7	-2.2	-1.3	-1.1	-1.6	-2.0	-0.8	-1.2
Respiratory disease	0.6	1.2	6.3	1.3	0.6	-0.3	-0.7	0.3	0.3	-1.5	0.4	-2.5	-0.8
Sensitivity / hurt feelings	0.6	1.0	2.4	-1.1	-1.4	0.5	1.5	0.6	-0.7	0.5	1.1	1.2	0.2
Severe depression (siblings)	0.6	0.6	2.3	-1.5	0.9	-1.1	0.3	-0.2	-0.2	-0.2	0.2	1.0	-0.8
Current tobacco smoking	0.6	0.9	2.7	-0.5	0.5	-1.4	-0.1	-1.1	0.3	-1.6	-0.9	-0.9	-1.2
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.5	-0.7	0.4	-0.8	0.6	-0.4	0.6	-1.2	-1.2	-0.9	-1.0
Qualifications: CSEs or equivalent	0.6	0.8	2.0	0.8	-0.5	0.4	1.3	-0.6	-1.2	-1.0	-1.0	-0.1	-1.4
Had menopause	0.6	0.7	3.5	-1.9	0.5	0.2	-0.9	0.6	-0.2	-1.2	-0.7	-0.1	-0.6
Pain all over the body in last month	0.6	0.6	1.8	-1.3	0.6	0.1	1.2	-0.0	0.3	-0.2	-0.6	1.3	0.6
Diabetes (self-reported)	0.6	0.9	2.3	1.3	-0.7	0.0	0.0	0.2	-1.4	-1.5	-0.4	-1.4	-0.2
Impedance of arm (right)	0.6	2.8	10.3	0.3	1.7	-0.8	2.5	0.2	3.2	1.1	1.8	2.0	0.2
Falls in the last year	0.6	0.9	3.2	-0.4	-1.8	0.1	1.8	-0.3	-0.1	-0.3	-0.1	-1.3	-0.4
Blood clot in the leg (DVT)	0.6	0.8	3.8	0.1	0.5	-1.1	-0.7	-0.9	-0.8	0.8	0.1	2.0	-0.4
Medication: Paracetamol	0.6	1.0	2.3	1.0	-0.5	1.1	0.5	1.3	0.2	1.5	1.3	-0.4	1.3
Medication: Ventolin 100micrograms inhaler	0.6	0.7	3.0	0.6	-0.6	0.5	0.2	0.0	-1.7	-0.2	-0.3	-1.5	1.1
Arm fat-free mass (right)	0.6	2.9	8.3	-1.9	1.9	-0.4	-1.9	-1.7	-0.9	-1.4	-2.9	-1.7	-0.9
Age at first live birth	0.6	1.0	4.6	0.5	0.2	0.9	-0.1	-0.3	1.0	1.4	-0.4	2.1	1.2
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.6	0.4	-1.0	0.7	-0.6	-0.1	-0.8	-0.7	-1.0	-1.3	1.0
Arm predicted mass (right)	0.6	3.0	8.7	-2.0	1.8	-0.4	-1.8	-1.8	-1.0	-1.5	-3.0	-1.8	-1.0
Comparative height size at age 10	0.6	3.0	12.3	-1.7	3.5	-1.8	-0.3	-2.0	2.0	-1.0	-1.1	0.2	-1.3
Had major operations	0.6	0.7	3.7	-0.1	0.4	0.5	-0.4	1.1	1.1	-0.0	0.6	1.9	0.4
Medication: Aspirin	0.6	0.7	2.6	-0.9	-0.5	0.3	-0.5	-1.0	-1.6	-0.3	-1.1	0.7	-0.7
Whole body fat-free mass	0.6	3.2	10.5	-2.2	2.4	-0.5	-1.2	-1.9	-0.1	-1.5	-3.2	-1.7	-0.7
Eye problems/disorders: Cataract	0.6	0.7	3.3	0.6	0.0	-0.2	1.8	0.1	0.6	1.1	0.9	1.0	0.6
Breast cancer (self-reported)	0.6	0.8	2.1	-0.8	0.7	0.9	0.4	1.4	1.4	0.2	1.1	0.3	0.6
Medication: Aspirin	0.6	0.8	1.9	-1.2	-0.6	0.0	-0.3	-1.1	-1.4	-0.0	-0.9	1.3	-0.8
Whole body water mass	0.6	3.2	10.4	-2.3	2.3	-0.5	-1.3	-1.9	-0.2	-1.4	-3.2	-1.7	-0.7
Average weekly champagne plus white wine intake	0.6	0.8	3.2	-1.1	0.8	0.2	0.4	0.1	0.5	1.4	0.7	1.8	0.0
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.7	-0.1	0.7	-1.4	-0.5	-1.1	-0.8	0.6	0.0	1.6	-0.7
Bipolar Disorder or Schizophrenia	0.5	1.3	6.5	-1.1	-0.9	0.7	-1.1	-0.0	-1.1	0.1	-0.2	2.5	1.1
Worry (Nagel 2018)	0.5	1.1	2.8	0.5	-0.5	0.7	-0.3	1.1	1.0	1.5	1.4	1.7	1.0
Ovarian Cancer	0.5	0.7	2.3	0.2	-0.7	-0.2	0.7	-1.1	-0.8	-1.1	-1.5	0.6	0.3
Mean Putamen Volume	0.5	0.6	1.3	-1.0	1.1	0.1	-1.2	0.2	0.7	0.2	-0.5	1.1	0.8
Schizophrenia (2014)	0.5	1.1	4.4	-1.5	-0.3	-0.0	-1.0	-0.7	-0.9	-0.3	-1.1	2.1	1.0
Triglycerides	0.5	0.8	2.8	-1.7	0.3	-1.4	0.7	-0.5	-0.4	-0.6	-0.8	-0.1	-0.9
Ulcerative Colitis	0.5	0.8	2.2	-1.0	1.2	1.5	-1.4	0.9	0.0	0.0	0.4	0.0	0.0
Blood White Count	0.5	3.6	9.2	0.5	2.3	2.8	0.1	2.3	3.0	-0.3	0.6	-2.2	1.6
Number of treatments/medications taken	0.5	1.0	1.9	-0.5	0.5	-0.9	-1.3	-0.9	-0.6	-0.8	-1.2	-1.2	-1.4
Serious illness, injury or assault to yourself	0.5	0.6	3.5	-0.1	0.9	-0.6	0.4	-0.1	1.9	-0.2	0.1	0.4	-0.9
Hayfever, allergic rhinitis or eczema	0.5	1.2	3.8	1.9	-1.2	0.7	-1.1	0.8	-0.1	0.8	1.5	-1.1	-0.4
Supplements: Glucosamine	0.5	0.7	2.6	0.3	-1.6	0.3	-1.4	0.9	0.6	0.2	0.5	-0.6	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.6	0.5	-0.5	1.1	-0.5	1.1	0.3	0.5	1.6	-0.4	1.1
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.9	-1.3	0.7	-0.2	-0.6	-0.5	1.0	0.2	-0.6	1.4	0.1
Mouth/teeth dental problems	0.5	0.7	1.5	0.9	1.2	1.1	-0.4	0.6	0.1	0.9	1.1	-0.9	-0.4
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.9	1.3	-0.9	-0.0	0.4	-0.1	-1.4	-0.5	0.5	-0.8	-0.6
Neuroticism score	0.5	1.1	2.8	-0.2	-1.6	1.1	0.8	1.3	0.4	0.8	1.7	-0.2	1.1
Hair/balding pattern: Pattern 3	0.5	0.8	4.0	-0.3	-0.5	0.4	-2.0	0.6	-1.1	0.8	0.4	-0.4	0.7
Illnesses of mother	0.5	0.7	1.8	-1.4	-0.3	-0.7	0.8	-0.9	-0.6	-0.6	-0.8	-0.9	-0.8
Pulse wave reflection index	0.5	0.6	3.8	0.4	0.3	0.6	-2.0	0.8	0.0	0.4	-0.6	-0.9	-0.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.3	-0.4	0.3	-0.2	1.1	-0.6	1.1	-0.1	-1.1	1.5	0.5
Birth weight	0.5	1.0	4.5	-2.1	1.6	-0.7	0.2	-0.2	1.3	0.6	-0.5	-0.2	-0.0
Worry too long after embarrassment	0.5	0.9	3.0	-0.1	-1.7	0.9	0.5	1.3	-0.3	-0.2	1.3	0.7	1.1
Wheeze or whistling in the chest in last year	0.5	0.9	3.9	-1.2	0.3	-0.1	0.2	-0.4	-0.1	-1.6	-0.5	-2.0	-0.7
Chest pain or discomfort	0.5	0.7	2.5	-0.1	0.1	0.1	-1.0	-0.7	-0.4	-1.2	-1.3	-1.6	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	6.6	0.1	1.3	0.4	0.8	-0.2	2.6	-0.3	-1.3	0.2	0.5
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.2	0.6	0.0	-0.8	1.1	-0.7	0.8	-0.3	-0.5	1.0	-1.0
Loneliness, isolation	0.5	0.7	3.0	0.4	-1.7	0.2	-0.1	0.5	-0.4	1.3	1.3	-0.1	0.6
Qualifications: nursing, teaching	0.5	0.8	1.9	1.0	-0.6	0.8	1.1	0.9	0.2	1.4	0.8	-0.3	1.3
Commuting to job workplace: Walk	0.5	0.5	2.1	-0.5	0.4	-0.5	0.3	-0.8	-0.4	0.8	-0.6	1.4	0.7
Mineral and other dietary supplements	0.5	0.7	3.0	-0.4	1.7	-0.2	1.7	0.0	0.4	0.2	-0.5	0.5	-0.0
Osteoarthritis (self-reported)	0.5	0.7	3.0	0.5	-0.9	-1.0	0.4	-1.0	-0.5	-0.0	-0.2	1.7	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	5.4	0.5	-0.6	1.6	-2.3	0.4	0.9	0.6	-0.4	-0.1	1.1
Ever smoked	0.5	0.9	3.4	-0.5	0.9	0.0	0.3	0.1	0.7	-1.1	-1.2	-1.8	-0.9
Basal metabolic rate	0.5	2.7	8.7	-2.1	2.2	-0.6	-0.9	-1.8	-0.3	-1.3	-3.0	-1.6	-0.7
Commuting to job workplace: Cycle	0.5	0.6	1.3	-0.9	0.7	-0.5	0.6	-1.1	0.8	-0.0	-1.0	1.2	-0.4
Schizophrenia (2018)	0.4	0.9	2.6	-1.6	-0.6	-0.5	-0.7	-1.2	-1.0	-0.6	-0.8	1.3	-0.2
Crohns Disease (2012)	0.4	0.7	5.4	-0.1	1.1	2.3	-0.4	0.0	0.0	0.0	0.0	0.0	0.0
Fasting Glucose	0.4	0.4	1.7	-1.3	0.8	-0.3	0.7	-0.1	0.3	-0.2	0.5	-0.6	-0.7
Lupus	0.4	0.5	2.2	0.9	-0.3	1.5	-1.1	0.1	0.3	0.2	0.0	-1.1	0.2
Type 2 Diabetes (T2D) (2012)	0.4	0.4	2.7	-0.5	1.6	-1.2	-0.4	0.0	0.0	0.0	0.0	0.0	0.0
Hypothyroidism (self reported)	0.4	0.8	2.7	-1.6	0.5	-1.5	0.6	-0.7	-0.4	-0.5	-0.7	-0.2	-1.1
Hearing difficulty/problems: Yes	0.4	0.5	1.4	0.6	0.2	0.4	-1.1	-0.6	-0.5	-1.1	-1.2	-0.5	-0.5
Ever had hysterectomy (womb removed)	0.4	0.4	1.1	-0.3	-0.6	-1.0	0.5	-1.0	-0.1	-0.3	-0.8	-0.0	-0.8
Systolic blood pressure, automated reading	0.4	1.2	4.6	0.8	-0.9	-0.3	-1.0	0.1	-1.6	-2.1	-1.4	-0.8	-0.6
Angina	0.4	0.5	1.0	0.6	0.2	0.2	-1.0	-0.2	0.9	-0.7	-1.0	0.6	-0.6
Vitamin and mineral supplements	0.4	0.5	2.3	-0.1	0.6	-1.5	1.0	-0.5	0.1	-0.3	-0.7	-0.3	-0.6
Supplements: Zinc	0.4	0.4	2.1	-1.5	-0.4	-0.0	0.5	-1.0	-0.2	-0.1	-0.9	-0.2	-0.0
Maternal smoking around birth	0.4	0.6	1.5	-1.2	0.9	1.2	0.7	0.6	0.1	0.5	0.0	-0.6	0.5
Stomach or abdominal pain in last month	0.4	0.5	1.5	1.0	-0.7	-0.7	-0.1	-0.5	0.2	-0.1	0.3	1.2	-1.0
Sitting height	0.4	3.2	7.0	-2.0	2.6	-1.5	-0.7	-2.1	1.2	-2.3	-1.9	-1.1	-1.4
Chronic bronchitis/emphysema (father)	0.4	0.5	1.6	-0.5	-0.4	-0.1	0.4	-0.7	-0.7	-1.3	-1.1	-0.8	0.0
Alcohol usually taken with meals	0.4	0.6	1.9	0.4	-1.4	-0.3	0.9	-0.4	-0.9	-0.2	0.6	1.4	-0.5
Forced vital capacity (FVC)	0.4	1.6	6.3	0.7	1.8	-0.2	-2.2	-0.5	2.5	-0.7	-0.2	-0.7	-0.1
Weight	0.4	2.0	5.7	-1.5	1.4	-0.9	0.2	-1.7	-1.4	-1.4	-2.4	-1.1	-1.1
Asthma	0.4	0.7	3.0	0.1	0.6	-0.7	-0.7	-0.4	0.3	-1.7	-0.6	-1.3	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	2.1	0.7	-1.4	0.8	0.1	0.5	0.2	0.7	0.8	0.4	0.1
Medication: Cholesterol lowering	0.4	0.6	3.0	0.8	-0.5	-0.1	-1.0	0.5	0.5	-0.4	-0.2	-1.7	-0.7
Depression (self-reported)	0.4	0.5	2.4	0.9	0.0	-0.9	0.2	-0.7	0.0	-0.1	-0.0	-0.5	-1.6
Hair/balding pattern: Pattern 4	0.4	0.9	4.5	1.2	0.2	-0.0	1.6	0.2	0.1	0.4	0.6	2.1	-0.2
Peak expiratory flow (PEF)	0.4	1.0	2.9	-0.1	1.7	0.4	-0.8	-0.3	1.4	-0.2	-1.4	-1.3	0.4
Glaucoma (self-reported)	0.4	0.5	1.2	1.1	-1.1	0.8	0.6	0.1	-0.3	-0.9	-0.8	0.3	0.6
Forced vital capacity (FVC), Best measure	0.4	1.5	7.6	1.4	1.6	0.2	-1.6	-0.0	2.8	-0.2	0.1	0.4	0.4
Angina (self-reported)	0.4	0.5	1.6	0.4	0.4	0.1	-0.9	-0.4	0.6	-1.0	-1.3	0.5	-0.8
Medication: Ibuprofen	0.4	0.5	1.1	-0.4	-1.1	0.8	-0.2	0.6	0.8	1.1	0.4	0.7	0.4
Medication: Seretide 50 evohaler	0.4	0.5	1.6	-0.5	0.3	-0.9	0.0	-0.9	-0.7	-0.7	0.3	-0.2	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	2.0	-0.0	-1.3	0.0	0.9	-0.4	-1.4	0.3	0.5	0.5	-0.3
Overall health rating	0.4	0.9	2.7	-0.9	0.3	-1.2	-0.3	-0.9	0.7	-1.4	-0.6	-0.8	-1.6
Supplements: Vitamin C	0.4	0.5	3.3	-1.8	-0.1	-0.9	0.1	-0.8	0.1	0.2	-0.2	0.3	-0.4
Smoking status: Previous	0.4	0.6	1.9	-0.6	0.7	0.8	-0.4	0.5	-0.2	-0.7	-0.5	-1.4	-1.1
Average weekly red wine intake	0.4	0.6	2.5	0.5	0.7	0.1	-0.5	0.5	-0.8	-0.0	1.1	-1.6	-0.8
Back pain experienced in last month	0.4	0.5	2.4	0.8	-0.9	-0.2	-1.6	0.2	0.0	-0.5	0.6	0.4	-0.8
Asthma (self-reported)	0.4	0.7	3.0	0.1	0.5	-0.7	-0.7	-0.2	0.2	-1.7	-0.3	-1.5	-0.8
Osteoporosis (self-reported)	0.4	0.5	1.4	-0.6	0.4	-1.1	1.2	-1.0	0.1	-0.3	-0.9	0.3	-0.3
Illnesses of father: None of the above (group 1)	0.4	0.5	1.2	-1.0	0.9	-0.7	0.8	-0.9	-0.0	0.3	-1.1	0.5	-0.2
Commuting to job workplace: Public transport	0.4	0.5	1.3	0.1	-0.0	0.8	1.1	-0.3	-0.5	0.7	-0.5	0.6	1.1
Eye problems/disorders: Glaucoma	0.4	0.5	2.3	0.7	-0.4	0.7	0.5	-0.0	0.1	0.3	-0.1	1.5	1.0
Medication: Bendroflumethiazide	0.4	0.6	2.2	-0.6	-0.4	-0.3	0.4	-0.5	-1.5	-0.6	-1.2	0.9	-0.1
Average weekly beer plus cider intake	0.4	0.6	2.0	-0.3	0.9	0.3	0.2	-0.4	0.1	-1.1	-1.4	-1.1	0.1
Ever depressed for a whole week	0.4	0.5	1.3	-1.2	-0.1	0.6	-0.3	-0.1	-1.1	0.9	0.2	1.1	0.1
Pain experienced in last month	0.4	0.6	1.5	-0.5	0.9	-0.8	-0.6	-1.1	-1.1	-0.2	-1.2	-0.5	0.1
Impedance of whole body	0.4	2.0	6.3	0.6	1.3	-1.2	1.9	0.2	2.5	0.5	2.0	1.4	-0.5
Leg fat mass (left)	0.4	1.4	5.7	-0.9	0.3	-0.4	0.2	-0.8	-2.4	-1.3	-1.6	-1.3	-1.0
Alzheimer’s Disease (in mother)	0.3	0.3	1.1	-0.0	0.7	-1.0	0.2	-0.9	0.4	0.2	-0.1	0.6	-0.4
Breast Cancer	0.3	0.8	3.0	1.6	0.2	-0.5	-0.5	-1.0	-0.2	-0.3	-0.7	0.6	-1.7
Body Mass Index (BMI) (2010)	0.3	0.4	1.5	-0.2	0.0	0.4	-0.8	0.3	-0.0	1.1	0.5	1.2	0.3
Heel T-Score	0.3	2.3	13.3	-0.8	-1.9	0.3	0.5	0.4	-3.6	-0.5	0.5	-2.1	-0.4
Systolic Blood Pressure	0.3	1.5	6.9	0.7	0.7	0.4	-1.6	0.1	-0.1	-2.6	-1.8	-1.0	0.4
Average weekly spirits intake	0.3	0.4	1.3	-0.5	0.6	-0.3	-0.3	-0.8	0.7	-0.4	-1.1	-0.4	-0.6
Leg fat-free mass (left)	0.3	1.7	4.9	-2.0	2.0	0.0	-0.7	-1.1	0.2	-0.7	-2.2	-1.3	-0.1
Hand grip strength (right)	0.3	0.8	5.7	0.2	0.5	-0.0	-2.4	-0.3	0.2	0.8	-0.6	0.8	0.2
Relative age voice broke	0.3	0.5	1.6	0.4	-0.5	0.9	0.6	1.3	0.5	0.4	1.0	0.5	0.4
Age when periods started (menarche)	0.3	0.6	2.2	0.5	1.1	0.6	-0.6	0.0	1.5	-0.9	-0.8	-0.7	0.0
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.6	0.4	-1.3	0.6	-0.4	0.2	-0.2	0.4	0.7	-0.3	-0.3
Body mass index (BMI)	0.3	1.2	8.5	-0.1	-1.0	0.4	0.1	-0.1	-2.9	-0.3	-1.1	-1.1	-0.2
Leg predicted mass (left)	0.3	1.7	5.2	-2.0	1.9	0.0	-0.7	-1.1	0.1	-0.8	-2.3	-1.2	-0.1
Trunk fat mass	0.3	1.4	2.0	-1.2	1.2	-1.1	1.2	-1.4	-1.4	-1.0	-1.4	-0.3	-1.1
Number of incorrect matches in round	0.3	0.5	1.5	0.7	-0.2	0.7	-0.8	0.2	1.2	-0.8	-0.7	-0.5	0.4
Past tobacco smoking	0.3	0.6	2.2	0.4	-0.4	-0.1	-0.1	0.1	0.2	1.1	0.9	1.5	1.3
Nervous feelings	0.3	0.6	2.1	0.5	-0.1	0.2	-0.4	0.8	1.2	0.3	0.2	1.2	1.4
Hearing difficulty/problems with background noise	0.3	0.5	1.9	0.0	-0.9	-0.5	-0.7	-0.7	-0.4	-0.7	-0.3	0.7	-1.4
Heart attack	0.3	0.4	2.2	-0.8	0.2	-0.6	1.5	-0.4	-0.1	0.2	-0.6	-0.1	-0.5
Fluid intelligence score	0.3	0.6	1.7	-0.3	1.1	0.3	0.3	0.4	1.3	1.0	1.3	0.4	0.4
Illnesses of siblings	0.3	0.4	1.9	-0.6	-0.2	0.3	0.8	-0.2	0.5	0.3	-0.6	0.6	1.4
Hip circumference	0.3	1.3	2.8	-1.6	0.4	-0.8	0.8	-1.1	-1.4	-1.2	-1.7	-0.8	-0.8
Alcohol intake versus 10 years previously	0.3	0.5	2.2	1.0	-0.6	0.1	1.5	0.3	0.7	-0.3	-0.0	-0.4	0.4
Father’s age at death	0.3	0.5	1.6	-1.3	-1.1	-0.2	0.9	-0.0	0.7	0.2	-0.3	-0.4	-0.6
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	4.1	0.8	1.2	0.1	-1.8	-0.2	2.0	0.1	-0.2	-0.6	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	4.2	1.5	0.6	0.8	-1.1	0.4	2.0	0.8	0.5	0.4	1.0
Pulse wave Arterial Stiffness index	0.3	0.3	0.7	-0.1	0.5	-0.4	-0.8	-0.5	-0.7	-0.3	-0.8	0.0	-0.7
High blood pressure (siblings)	0.3	0.4	1.1	0.5	0.1	0.1	-1.0	0.4	-1.1	-0.5	0.3	-1.1	-0.6
Comparative body size at age 10	0.3	0.8	2.8	-0.2	-0.4	0.2	-1.7	-0.5	0.0	0.7	-1.1	1.6	0.4
Number of children fathered	0.3	0.4	1.3	-0.0	0.7	-1.1	0.5	-0.6	0.2	-0.1	-0.5	0.7	-0.9
Health satisfaction	0.3	0.4	1.0	0.2	-0.7	0.6	0.8	1.0	-0.3	0.8	0.9	0.3	0.1
Qualifications: College or University degree	0.3	1.0	2.8	1.3	-0.7	1.7	-0.1	1.4	1.1	0.6	1.0	-0.5	0.8
Medication for pain relief, constipation, heartburn	0.3	0.5	1.0	-0.9	0.9	-0.9	-0.8	-0.4	0.2	-0.8	-0.4	-1.0	-0.5
Whole body fat mass	0.3	1.4	2.6	-1.1	1.3	-0.9	1.1	-1.3	-1.4	-1.1	-1.6	-0.8	-1.1
Leg fat mass (right)	0.3	1.2	3.8	-0.9	0.3	-0.5	0.1	-0.8	-1.9	-1.1	-1.5	-1.1	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.1	-0.4	0.4	0.4	0.2	-0.7	-0.5	-0.1	-1.1	0.9	0.6
Leg fat-free mass (right)	0.3	1.6	4.7	-1.9	2.0	0.2	-0.7	-1.1	-0.0	-0.7	-2.2	-1.2	-0.1
Leg predicted mass (right)	0.3	1.6	4.9	-2.0	2.0	0.2	-0.6	-1.1	-0.1	-0.7	-2.2	-1.2	-0.1
Medication: Lisinopril	0.3	0.4	1.2	0.5	1.0	0.3	-0.7	0.7	1.1	0.5	0.5	0.5	-0.4
Leg fat percentage (left)	0.3	1.1	7.5	0.5	-0.8	0.3	0.1	0.1	-2.7	-0.6	-0.8	-1.0	-0.5
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.5	-0.9	0.5	-0.7	1.2	-0.4	0.0	0.2	-0.6	-0.1	-0.5
Alzheimer’s Disease (including proxy)	0.2	0.3	1.3	0.4	0.1	-0.4	0.3	0.1	0.3	1.1	1.2	-0.1	0.4
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.3	0.0	-1.1	0.5	-0.1	0.2	-0.3	1.1	0.9	1.1	0.5
HDL Cholesterol	0.2	0.4	2.2	0.3	-0.3	1.5	-0.5	0.7	0.0	0.4	0.5	-0.5	0.1
Neuroticism (2016)	0.2	0.3	0.7	0.3	-0.8	0.0	0.4	0.8	-0.2	0.6	0.7	-0.2	0.7
Blood Eosinophil Count	0.2	1.4	7.2	0.0	0.9	0.7	0.1	1.3	1.5	-0.0	1.3	-2.7	0.3
BMI	0.2	1.4	9.3	0.1	-1.6	0.7	0.7	0.4	-3.0	0.2	-0.5	-1.0	0.4
Relative age of first facial hair	0.2	0.4	1.1	0.3	-0.8	0.6	0.7	0.1	0.5	-0.8	-0.7	1.1	0.5
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.7	0.6	-0.6	0.3	0.3	0.2	0.2	0.8	0.8	0.2	0.4
Impedance of leg (right)	0.2	1.0	4.2	0.1	1.0	-1.1	0.7	0.1	2.1	0.2	1.3	0.9	-0.6
Trunk fat percentage	0.2	0.8	2.2	-0.5	0.6	-1.0	1.5	-0.8	-1.4	-0.5	-0.3	0.2	-1.0
Fed-up feelings	0.2	0.4	1.1	-0.5	0.3	0.6	-0.8	0.4	0.5	0.2	0.9	-0.3	1.1
Impedance of leg (left)	0.2	0.8	1.7	0.3	1.2	-1.0	0.8	-0.1	1.3	0.0	1.2	0.7	-0.9
Qualifications: None of the above	0.2	0.5	1.1	-0.9	0.4	-0.8	0.6	-0.6	0.8	-1.0	-0.5	0.9	0.1
Financial difficulties in last 2 years	0.2	0.3	1.5	-0.0	-1.2	-0.1	-0.3	0.2	0.5	-0.0	0.3	0.9	0.5
Allergy	0.2	0.6	2.0	-0.8	0.3	0.6	1.4	0.5	0.3	0.8	-0.2	0.8	1.1
Worrier / anxious feelings	0.2	0.4	1.1	0.5	-0.6	-0.0	-0.3	0.4	0.5	1.0	0.9	0.6	0.4
Arm fat mass (right)	0.2	0.8	2.7	-0.9	0.6	-0.3	0.9	-0.8	-1.6	-0.6	-1.4	-0.7	-0.5
Headache pain in last month	0.2	0.4	2.0	0.1	-0.7	-0.3	1.4	-0.5	0.0	-0.1	0.1	1.1	-0.0
Body fat percentage	0.2	0.7	3.6	-0.2	0.2	-0.5	1.4	-0.5	-1.9	-0.4	-0.4	0.1	-0.8
Leg fat percentage (right)	0.2	0.7	4.5	0.3	-0.9	0.0	-0.1	-0.0	-2.1	-0.5	-0.7	-0.7	-0.4
Shortness of breath walking on level ground	0.2	0.3	1.3	-0.1	0.2	0.6	0.3	0.7	0.7	0.1	-0.4	-1.1	0.2
Age at last live birth	0.2	0.4	1.3	-0.6	0.4	0.5	-0.2	-0.5	0.6	0.6	-0.7	1.1	0.2
Illnesses of father: Heart disease	0.2	0.3	1.7	0.2	-0.5	-0.4	-0.8	-0.6	-0.1	0.1	0.3	1.3	-0.1
Arm fat mass (left)	0.2	0.7	3.0	-0.8	0.3	-0.3	0.7	-0.7	-1.7	-0.6	-1.1	-0.5	-0.5
Diastolic blood pressure, automated reading	0.2	0.7	2.6	-0.3	-0.4	-0.1	-0.1	0.1	-1.6	-1.5	-1.3	0.2	-0.1
Cholesterol lowering medication	0.2	0.3	0.9	0.8	-0.3	0.7	-0.3	0.1	0.2	-0.2	-0.1	0.6	-1.0
Supplements: Calcium	0.2	0.2	0.8	-0.3	-0.9	0.2	0.8	-0.4	-0.0	0.5	-0.6	0.0	-0.2
Intelligence (Savage-Jansen 2018)	0.1	0.3	2.1	0.1	-0.1	-0.2	-0.4	-0.4	-0.3	0.3	-0.2	1.5	-0.0
Lung FEV1/FVC ratio	0.1	0.4	1.3	-0.7	-1.1	0.5	-0.1	-0.4	-0.6	0.4	-0.6	0.4	0.6
Lung FVC	0.1	0.6	4.0	0.8	-0.1	-0.6	-2.0	-0.2	0.1	-0.0	0.3	-0.2	-0.9
Neuroticism	0.1	0.3	1.5	-0.6	-1.2	0.1	0.9	0.2	0.2	-0.1	0.3	0.2	0.5
Tanning	0.1	0.8	2.2	0.3	-1.5	-0.7	0.7	-0.1	-0.2	-0.4	1.5	0.4	-1.5
Hair/balding pattern: Pattern 2	0.1	0.2	0.6	0.4	-0.0	0.0	-0.1	0.5	0.8	-0.2	0.0	0.3	-0.6
Arm fat percentage (right)	0.1	0.6	3.1	0.2	-0.6	0.2	1.5	-0.0	-1.8	0.1	-0.2	-0.2	0.0
Tense / ‘highly strung’	0.1	0.2	0.8	-0.1	0.8	0.1	0.9	0.5	0.3	0.5	0.5	-0.2	0.2
Medication: Amlodipine	0.1	0.2	0.4	-0.1	0.6	0.1	-0.6	-0.3	0.3	0.0	0.1	0.6	-0.6
Pulse wave peak to peak time	0.1	0.1	0.6	-0.1	-0.1	0.0	0.8	0.0	0.7	-0.2	0.3	-0.1	0.4
Neck or shoulder pain in last month	0.1	0.2	0.6	-0.2	-0.7	0.3	0.0	0.2	-0.1	-0.4	0.0	-0.8	-0.3
Suffer from ‘nerves’	0.1	0.2	0.7	-0.0	-0.4	-0.9	0.5	-0.4	-0.5	-0.3	0.1	-0.2	-0.7
Leg pain on walking	0.1	0.1	0.3	0.3	-0.1	0.0	-0.4	0.0	-0.5	0.4	-0.4	-0.4	0.1
Arm fat percentage (left)	0.1	0.6	3.1	0.2	-0.7	0.1	1.4	0.1	-1.8	0.3	0.2	0.1	-0.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.9	2.2	0.6	0.3	0.7	-0.7	0.9	-1.5	1.4	0.8	-0.4	1.2

Hub : Genes

SYNGR2

Models

Trait associations