TWAS hub - TMC8

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1370	0.0460	3.3e-03	0.019	NA	0.015	NA	0.012	1.0e-02	NA	1.8e-02	NA	3.4e-02
2	GTEx	Skin Sun Exposed Lower leg	0.1360	0.0490	7.8e-03	0.003	NA	-0.003	NA	0.001	1.6e-01	NA	8.0e-01	NA	2.4e-01
3	YFS	Blood	0.3156	0.0299	0.0e+00	0.227	0.201	0.240	0.238	0.230	7.2e-73	8.0e-64	1.7e-77	1.4e-76	8.6e-74
4	TCGA	Breast Invasive Carcinoma	0.0525	0.0197	9.3e-05	0.005	0.032	0.033	NA	0.024	3.1e-02	3.2e-07	1.9e-07	NA	7.8e-06
5	TCGA	Brain Lower Grade Glioma	0.1061	0.0366	7.4e-06	0.068	0.055	0.065	NA	0.074	3.9e-08	7.2e-07	7.8e-08	NA	9.4e-09
6	TCGA	Stomach Adenocarcinoma	0.1180	0.0540	3.8e-03	-0.003	0.019	0.004	NA	-0.004	7.6e-01	1.4e-02	1.6e-01	NA	8.9e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Noisy workplace	4.7	5.7	13.8	2.4	1.3	-1.5	3.7	2.5	2.2
Blood Red Count	3.9	37.8	141.6	4.5	-3.4	1.1	2.2	11.9	-6.9
Townsend deprivation index at recruitment	2.9	4.0	6.6	2.4	2.4	-2.6	1.9	1.2	1.1
Alzheimer’s Disease (in father)	2.8	3.0	5.3	-2.3	-0.8	1.8	-1.6	-1.8	-1.7
Serious illness, injury or assault of a close relative in last 2 years	2.8	3.2	5.2	-1.4	-2.3	1.8	-1.6	-1.7	-1.9
HbA1C	2.5	2.7	8.2	1.4	1.2	-0.2	1.5	2.9	-1.6
Medication: Ventolin 100micrograms inhaler	2.5	3.2	8.8	1.5	3.0	-2.6	0.7	0.1	1.0
Medication: Aspirin	2.5	3.3	9.5	1.3	1.5	-2.1	3.1	0.8	1.1
Commuting to job workplace: Walk	2.3	2.4	5.8	0.2	1.0	-2.1	2.4	-0.7	1.7
Unable to work because of sickness or disability	2.3	3.0	7.2	1.5	2.7	-2.4	1.4	-0.0	0.9
Heart disease (mother)	2.2	2.6	7.3	1.3	0.2	-0.7	2.2	2.7	1.1
Alzheimer’s Disease (including proxy)	2.0	2.9	5.8	-2.4	-2.1	1.7	-1.4	-1.4	0.2
Prospective memory result	2.0	2.4	3.3	1.8	1.4	-1.7	1.6	1.7	0.9
Birth weight	2.0	4.4	7.7	-2.8	-2.6	1.8	-2.2	-1.4	-1.4
Illnesses of father: Heart disease	2.0	2.8	7.8	0.7	-1.8	1.6	1.5	2.8	-0.9
Medication: Aspirin	2.0	2.6	8.4	0.9	1.2	-1.8	2.9	0.4	1.1
Supplements: Vitamin C	1.9	2.2	5.7	-1.0	-0.7	1.4	-2.4	-2.0	-0.2
Wears glasses or contact lenses	1.7	2.0	4.6	2.1	1.0	-1.1	1.1	0.5	1.9
Pack years adult smoking proportion	1.6	2.4	5.0	-0.3	1.7	-2.2	1.2	-0.7	2.1
Number of live births	1.6	2.3	6.9	-0.8	-1.2	0.4	-2.6	-2.1	-0.5
Pack years of smoking	1.6	2.3	6.1	-0.3	1.7	-2.5	1.1	-0.3	1.8
Gout (self-reported)	1.5	2.1	6.7	0.5	0.8	-1.0	1.9	0.7	2.6
Had major operations	1.5	1.8	4.5	-1.4	-2.1	0.7	0.4	1.6	-0.9
Basal cell carcinoma (self-reported)	1.5	1.8	3.4	-1.9	-1.3	1.4	-1.1	0.4	-1.4
Breast Cancer	1.4	3.3	9.9	1.8	1.3	0.1	2.1	0.8	3.1
Maternal smoking around birth	1.4	2.0	4.0	-0.6	-0.0	0.4	-1.8	-2.0	-2.0
Diabetes diagnosed by doctor	1.4	2.3	5.2	1.6	2.2	-2.3	0.6	-0.6	0.8
Ovarian Cancer	1.3	1.7	4.6	0.8	0.8	-2.1	0.7	0.7	1.8
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	5.2	-2.3	-0.3	0.8	-1.4	-1.1	0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.5	-1.0	-1.9	1.3	-0.4	1.1	-1.0
Commuting to job workplace: Cycle	1.3	1.6	2.7	-1.2	-1.0	1.5	-1.3	-0.6	-1.6
Bipolar Disorder (2018)	1.2	1.8	5.5	-0.3	-1.0	0.8	0.0	2.3	-2.0
Type 2 Diabetes (T2D) (2018)	1.2	2.2	5.5	1.2	1.9	-2.3	1.3	-0.7	0.5
Number of treatments/medications taken	1.2	2.2	7.6	0.6	1.4	-2.8	1.1	-0.3	1.4
Medication: Metformin	1.2	1.7	5.9	1.0	1.7	-2.4	0.2	-0.7	0.1
Fluid intelligence score	1.2	2.5	5.5	-1.2	-2.4	2.1	-1.0	-1.0	-1.3
Long-standing illness, disability or infirmity	1.2	1.8	4.8	0.9	1.2	-2.2	1.6	-0.2	1.1
Mean Putamen Volume	1.1	1.3	3.3	-0.5	-1.8	0.8	-1.0	0.0	-1.5
Average weekly spirits intake	1.1	1.4	4.0	1.6	2.0	-0.7	0.9	0.3	0.3
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	3.3	-0.1	1.2	-0.4	1.8	-0.1	1.5
Qualifications: CSEs or equivalent	1.1	1.5	3.5	1.9	1.8	-1.0	0.7	0.8	-0.4
Mouth/teeth dental problems	1.1	1.6	6.5	-0.2	-1.1	0.6	-1.3	-2.5	-0.3
Pulse rate	1.1	1.8	5.1	1.3	2.2	-1.5	1.1	-0.0	-0.9
Mouth/teeth dental problems: Dentures	1.1	1.9	6.0	0.7	-0.3	-1.5	1.6	2.4	0.2
Number of full brothers	1.1	1.4	3.6	0.2	-1.9	1.3	-1.4	-0.6	-0.9
Commuting to job workplace: Car/motor vehicle	1.1	1.2	2.6	-1.3	-0.2	1.0	-1.6	-1.4	-0.2
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	3.0	1.7	1.2	-1.1	0.2	1.4	-0.8
Average weekly champagne plus white wine intake	1.1	1.4	4.0	-0.1	-1.2	2.0	-0.7	0.8	-1.5
Pain type(s) experienced in last month: Hip pain	1.1	1.3	2.7	1.6	1.2	-1.6	-0.3	1.0	0.7
Medication: Bendroflumethiazide	1.1	1.6	3.5	1.2	-0.4	-1.4	1.3	1.9	-0.9
Frequency of depressed mood in last 2 weeks	1.0	1.4	4.0	1.3	1.1	-2.0	0.3	-0.2	1.1
Diabetes (self-reported)	1.0	1.5	4.1	1.6	1.2	-2.0	0.6	-0.4	0.8
Lung cancer (father)	1.0	1.2	2.1	1.1	1.4	-0.8	1.4	0.5	1.0
Loud music exposure frequency	1.0	1.1	2.7	-0.1	-0.7	1.5	-1.0	-0.2	-1.6
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	4.5	1.5	-0.6	1.3	0.2	2.1	-1.0
Medication for pain relief, constipation, heartburn	1.0	1.6	3.6	-0.9	-0.4	1.5	-1.9	-1.1	-1.3
Medication: Blood pressure	1.0	1.7	5.9	-1.7	-0.6	-0.1	-0.8	-2.4	0.5
Pulse rate, automated reading	1.0	3.1	9.6	1.7	0.4	-0.9	3.1	2.3	0.0
Illnesses of siblings: Diabetes	1.0	1.2	3.7	0.4	0.5	-1.9	-0.4	-1.3	1.1
Financial situation satisfaction	1.0	1.3	4.6	1.4	-0.2	0.7	0.6	2.1	-0.4
Commuting to job workplace: Public transport	1.0	1.2	2.9	1.4	1.7	-1.1	0.7	0.1	0.8
Pain experienced in last month	1.0	1.6	3.2	1.8	1.8	-0.3	0.9	1.4	0.7
Alzheimer’s Disease (in mother)	0.9	1.1	2.5	-1.3	-1.6	0.4	-0.1	-0.1	1.5
Taking other prescription medications	0.9	1.4	5.5	0.2	0.7	-2.3	0.5	-0.3	1.4
Waist circumference	0.9	3.1	8.5	1.9	1.8	-2.9	1.3	0.7	1.1
Medication: Cholesterol lowering	0.9	1.4	2.7	-0.7	1.5	-1.6	0.8	-0.9	1.2
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.5	-1.0	-0.4	0.3	-1.6	-1.4	-0.9
Number of children fathered	0.9	1.0	5.8	-2.4	-0.1	0.1	-0.1	0.1	0.0
Medication: Gliclazide	0.9	1.0	2.2	0.9	1.0	-1.5	-0.7	-1.0	0.8
Illnesses of father: None of the above (group 1)	0.9	1.1	3.7	-0.5	1.1	-0.1	-1.9	-1.1	0.6
Tinnitus: Yes, now most or all of the time	0.9	1.1	1.6	-0.9	-1.3	1.2	-0.0	0.9	-1.3
LDL Cholesterol	0.8	1.2	3.1	0.1	-1.0	1.5	0.0	1.1	-1.8
Chronotype (morning person)	0.8	1.8	5.2	-0.6	0.9	0.6	-1.7	-1.1	-2.3
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	4.4	0.0	0.3	0.0	2.1	0.2	1.2
Serious illness, injury or assault to yourself	0.8	1.0	2.2	-1.0	-0.5	0.8	-0.8	-1.5	1.1
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	5.1	0.6	0.1	0.4	0.1	0.4	-2.3
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	3.3	1.2	1.8	-1.8	1.4	1.0	-0.4
Depression (self-reported)	0.8	1.0	2.7	0.1	1.0	-1.2	0.9	0.3	1.7
Impedance of arm (left)	0.8	3.7	9.7	-2.9	-1.7	3.1	-0.8	0.5	-0.5
Hair/balding pattern: Pattern 4	0.8	2.1	5.4	2.3	-0.2	0.4	1.7	1.3	1.4
Headache pain in last month	0.8	1.3	2.7	-1.6	-1.6	0.1	0.3	-0.3	1.6
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.5	-0.9	-1.6	1.2	-0.5	0.1	-0.5
Suffer from ‘nerves’	0.8	1.2	2.3	1.5	1.2	-1.1	1.5	0.6	0.1
Age at last live birth	0.8	1.1	3.1	-0.4	-1.8	1.1	-1.2	-0.9	-0.1
Handedness (chirality/laterality): Left-handed	0.8	0.9	3.8	-0.5	0.2	0.8	0.6	1.9	0.7
Ever had bowel cancer screening	0.8	0.9	2.7	-1.6	-0.2	0.0	-1.6	0.1	0.2
Friendships satisfaction	0.8	0.9	3.6	-0.6	-1.9	0.6	-0.5	0.5	-1.0
Eye problems/disorders: Glaucoma	0.8	0.9	4.0	0.5	0.5	0.7	0.7	2.0	-0.4
Medication: Blood pressure	0.8	1.6	2.9	1.2	1.3	-1.5	1.1	1.7	-0.2
Medication: Atorvastatin	0.8	1.0	2.8	-0.4	1.1	-1.1	-0.7	-1.7	-0.1
Leg fat percentage (left)	0.8	2.9	10.5	1.3	1.9	-3.2	0.9	0.7	-0.4
Heel T-Score	0.7	5.3	11.6	-0.3	1.4	-1.1	-3.3	-2.5	-3.4
Diabetes (mother)	0.7	0.8	1.5	-0.1	0.6	-0.9	-1.1	-1.2	1.2
Impedance of leg (right)	0.7	3.5	10.9	-3.3	-0.8	2.2	-2.0	-0.8	-0.5
Body mass index (BMI)	0.7	3.1	8.9	2.1	1.9	-3.0	1.2	0.1	0.1
Alcohol usually taken with meals	0.7	1.2	2.9	1.7	0.2	0.8	1.4	1.2	0.2
Pain all over the body in last month	0.7	0.7	3.8	-0.2	-0.3	-0.5	-0.2	1.9	-0.4
Happiness	0.7	0.9	2.2	0.3	-1.3	0.5	-0.3	1.5	-1.0
Blood clot in the leg (DVT)	0.7	0.9	2.7	-0.0	-1.5	-0.1	0.4	0.6	1.6
Glaucoma (self-reported)	0.7	0.8	3.1	0.3	1.1	0.3	-0.0	1.8	-0.5
Comparative body size at age 10	0.7	1.8	5.6	1.3	-0.4	-0.0	2.4	1.1	1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	3.1	-0.2	-0.1	0.3	-1.1	-0.2	-1.8
Health satisfaction	0.7	0.9	1.6	0.6	0.3	-1.1	1.2	1.3	0.7
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.2	0.4	1.5	-1.2	0.4	-0.5	0.7
Medication: Omeprazole	0.7	0.8	1.9	-0.9	-1.4	0.7	-1.0	-0.5	-0.5
Guilty feelings	0.7	1.1	3.1	0.5	1.3	-1.1	1.8	0.7	-0.3
Alcohol drinker status: Never	0.7	0.9	2.0	-1.0	0.4	-1.2	-0.6	-0.6	-1.4
Ever smoked	0.7	1.3	3.3	-0.3	1.4	-1.3	0.2	-1.8	0.9
Vascular/heart problems diagnosed by doctor	0.7	1.8	4.0	-1.2	-0.3	2.0	-1.8	-1.2	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.7	0.8	2.8	-0.2	-1.4	0.0	0.2	0.6	1.7
Impedance of whole body	0.7	3.4	10.5	-3.2	-1.3	2.5	-1.3	0.1	-0.7
Ulcerative Colitis (UC)	0.6	1.1	3.2	-0.5	-1.8	1.3	-0.6	-1.0	-0.1
Body Mass Index (BMI) (2010)	0.6	0.8	1.7	-0.4	-1.3	1.3	0.0	0.0	-1.3
Coronary Artery Disease (CAD)	0.6	0.7	2.5	-1.6	-0.1	1.2	0.0	0.0	0.2
Type 2 Diabetes (T2D) (2012)	0.6	0.6	2.2	-0.1	-0.8	1.5	0.0	0.0	-1.0
Blood Platelet Count	0.6	7.1	18.3	0.0	3.0	-1.3	1.6	-4.3	3.4
Angina	0.6	0.8	2.4	-0.1	-0.3	-0.5	1.4	-0.6	1.5
Severe depression (siblings)	0.6	0.6	1.1	-0.8	-1.1	0.3	-1.1	0.4	-0.7
Current tobacco smoking	0.6	1.1	4.5	0.3	0.4	-0.3	1.1	-0.6	2.1
Hair/balding pattern: Pattern 2	0.6	0.8	2.3	-0.1	1.5	-0.3	0.2	-1.0	1.1
Financial difficulties in last 2 years	0.6	0.8	1.4	-0.9	-0.9	0.9	1.2	0.9	0.2
Time employed in main current job	0.6	0.7	3.2	0.4	0.1	0.8	-0.1	1.8	0.1
Falls in the last year	0.6	0.8	2.2	-0.3	0.4	-1.0	-0.3	-1.2	1.5
Medication: Lansoprazole	0.6	0.7	1.5	-0.8	-0.1	-0.9	0.9	1.2	0.4
Illnesses of mother	0.6	0.7	2.7	0.3	0.9	-0.6	-0.7	-1.6	-0.1
Pulse wave Arterial Stiffness index	0.6	0.7	2.9	0.7	0.4	-0.3	0.3	1.7	0.7
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	2.0	-0.7	-0.0	0.9	0.9	1.4	-0.3
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	4.4	0.5	-0.4	-1.1	0.8	2.1	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	2.2	-1.1	0.6	-0.4	0.4	-1.5	0.4
Shortness of breath walking on level ground	0.6	0.7	1.9	0.4	0.5	-1.4	1.0	0.8	0.4
Angina (self-reported)	0.6	0.8	2.3	0.0	0.0	-0.6	1.4	-0.5	1.5
Medication: Allopurinol	0.6	0.8	2.6	0.4	0.4	0.3	0.9	0.8	1.6
Knee pain experienced in last month	0.6	0.9	1.8	1.3	0.1	-0.7	1.3	-0.5	-1.0
Smoking status: Previous	0.6	0.9	2.4	0.4	1.5	-1.4	-0.0	-0.1	-0.8
Eye problems/disorders: Cataract	0.6	0.6	3.5	0.2	0.2	0.5	1.9	0.2	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.8	-0.3	-1.2	0.6	-0.6	1.3	0.1
Breast cancer (self-reported)	0.6	0.7	2.1	0.6	-1.1	0.1	1.4	-0.6	-0.3
Mother’s age at death	0.6	0.7	1.8	0.0	1.3	-1.0	-0.8	0.1	1.0
Diastolic blood pressure, automated reading	0.6	1.8	4.1	1.3	0.7	-1.9	0.9	2.0	-0.6
Prostate Cancer	0.5	0.8	3.7	0.6	-0.1	0.4	0.4	1.9	0.4
Primary Biliary Cirrhosis	0.5	0.7	2.3	0.4	-0.5	1.1	-0.7	0.0	-1.5
BMI	0.5	2.6	7.8	1.5	2.2	-2.8	0.4	-0.7	-0.0
Sensitivity / hurt feelings	0.5	0.8	3.7	0.8	-0.1	-0.6	-0.3	0.0	-1.9
Hearing difficulty/problems: Yes	0.5	0.7	1.7	1.2	0.3	-0.7	0.6	0.4	1.3
Systolic blood pressure, automated reading	0.5	1.4	4.1	1.5	1.0	-2.0	0.3	1.0	0.1
Medication: Co-codamol	0.5	0.6	1.5	-1.2	-0.2	0.3	-1.0	0.8	0.4
High blood pressure	0.5	1.5	4.1	1.3	0.4	-2.0	1.3	1.0	0.5
Impedance of leg (left)	0.5	2.5	7.3	-2.7	-0.6	1.5	-2.0	-0.1	-1.2
Number of incorrect matches in round	0.5	0.9	3.7	-0.8	-1.9	0.2	-0.9	0.3	-0.0
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.3	1.1	1.1	-1.0	0.8	-0.3	-0.3
Arm fat percentage (right)	0.5	2.0	6.1	1.4	1.2	-2.5	1.4	0.2	0.4
Hair/balding pattern: Pattern 3	0.5	0.7	2.0	0.3	0.7	-1.4	-0.5	-1.2	-0.4
Length of working week for main job	0.5	0.6	1.6	1.2	1.3	-0.2	0.1	-0.5	-0.2
Leg fat percentage (right)	0.5	2.0	6.9	0.8	1.8	-2.6	0.9	0.4	0.1
Pulse wave peak to peak time	0.5	0.6	1.9	-0.8	-0.5	0.5	-0.4	-1.4	-0.6
Emphysema/chronic bronchitis	0.5	0.5	1.3	-0.9	0.4	-1.2	-0.8	-0.1	0.6
Migraine (self-reported)	0.5	0.6	1.7	-1.1	0.0	-1.3	-0.8	0.2	-0.3
Number of full sisters	0.5	0.7	2.8	-0.9	-0.1	-0.6	-0.0	-1.7	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.0	1.0	0.9	0.3	-0.4	0.8	-0.9
Hypertension (Self-reported)	0.5	1.3	2.9	1.0	0.5	-1.7	1.4	1.2	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	3.0	0.2	-0.3	0.2	0.1	0.8	1.7
Mood swings	0.5	0.9	4.1	1.2	-0.1	0.1	-0.1	-0.4	-2.0
Osteoporosis (self-reported)	0.5	0.6	2.8	-0.0	0.2	-0.5	0.7	0.5	1.7
Osteoarthritis (self-reported)	0.5	0.6	2.4	0.4	-0.6	0.4	0.8	1.6	0.0
Smoking status: Current	0.5	0.8	3.2	0.2	0.3	-0.3	1.0	-0.5	1.8
Ever taken oral contraceptive pill	0.5	0.5	2.2	0.4	0.6	0.4	0.6	1.5	-0.2
Irritability	0.5	0.8	3.7	-0.5	-0.0	0.5	-0.3	-0.5	-1.9
Risk taking	0.5	0.7	1.6	-1.0	0.1	1.2	0.3	-1.3	-0.3
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.6	-1.3	-1.0	-0.0	-0.9	-0.5	-0.2
Bipolar Disorder or Schizophrenia	0.4	1.0	2.8	-0.8	-1.1	0.5	0.0	1.7	-1.2
Depressed Affect (Nagel 2018)	0.4	0.9	3.2	-0.5	-1.8	1.2	0.1	-0.6	-0.5
Irritable Bowel Disease (IBD)	0.4	0.9	1.5	-1.1	-1.2	0.9	-0.9	-0.9	0.4
Reaction Time	0.4	0.7	1.2	-1.0	1.0	-0.2	-0.9	0.0	-1.1
Fasting Glucose	0.4	0.4	2.0	-0.4	-0.4	0.1	-0.5	-1.4	-0.1
Neuroticism (2016)	0.4	0.5	1.1	1.1	0.3	-0.5	1.0	-0.7	0.5
Blood White Count	0.4	2.7	8.2	-0.9	-0.3	1.1	-1.4	-2.9	-1.9
Cardiovascular Disease	0.4	1.4	3.0	1.7	0.9	-1.6	0.8	0.5	1.0
Hand grip strength (left)	0.4	0.9	1.8	1.3	-0.3	0.8	0.1	1.4	1.2
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.9	0.4	0.4	-0.5	-1.4	-0.5	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.5	-0.5	1.1	-1.6	-0.8	-0.7	-0.5
Multivitamins +/- minerals	0.4	0.5	2.0	0.6	0.1	0.4	0.6	-0.1	-1.4
Stomach or abdominal pain in last month	0.4	0.5	1.1	-0.5	-0.9	1.0	-0.7	-0.6	0.3
Medication: Levothyroxine sodium	0.4	0.7	2.3	-0.4	0.1	-1.2	-0.0	1.5	-0.4
Chronic bronchitis/emphysema (father)	0.4	0.5	0.7	0.8	0.8	-0.7	0.6	0.3	0.8
Had menopause	0.4	0.5	1.1	0.7	0.2	-0.4	0.5	0.9	-1.0
Forced vital capacity (FVC)	0.4	1.7	5.2	-1.4	-0.7	2.3	-1.1	-0.1	1.2
Qualifications: None of the above	0.4	0.8	2.2	-1.4	-1.5	-0.1	-0.5	0.0	0.4
Heart attack	0.4	0.5	1.3	-1.1	0.3	-0.4	1.0	0.5	0.1
Impedance of arm (right)	0.4	1.9	5.2	-2.3	-1.2	2.1	-0.4	0.0	0.5
Hip circumference	0.4	1.8	5.5	1.3	1.4	-2.3	0.8	-0.2	1.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	4.8	-0.9	-0.7	2.2	-1.1	0.1	0.8
Exposure to tobacco smoke at home	0.4	0.5	1.3	-0.3	0.5	-1.1	-0.3	-1.1	-0.3
Birth weight of first child	0.4	0.7	2.6	-1.6	0.5	0.5	-0.6	-0.8	-0.6
Pulse wave reflection index	0.4	0.4	1.5	0.8	-0.0	-0.0	0.6	0.2	1.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.0	-0.5	0.0	0.6	-1.0	-0.3	-1.4
Medication: Paracetamol	0.4	0.7	1.3	-0.4	-0.7	-1.1	0.9	0.3	1.1
High blood pressure (siblings)	0.4	0.6	2.0	0.2	-0.1	0.3	-0.3	1.4	-1.1
Exposure to tobacco smoke outside home	0.4	0.5	2.3	0.2	-0.5	0.5	1.5	-0.3	-0.4
Worry too long after embarrassment	0.4	0.6	1.8	-0.2	-0.6	0.7	-0.4	-1.0	-1.3
Eye problems/disorders: None of the above	0.4	0.4	1.1	-0.2	-1.0	-0.3	-1.0	0.0	-0.5
Mean time to correctly identify matches	0.4	0.8	1.7	-1.3	0.9	-0.5	-1.2	0.2	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.1	0.6	-0.5	-0.7	-0.4	0.9	-1.0
Leg pain on walking	0.4	0.5	1.8	-0.2	0.1	-1.3	-0.1	0.6	0.8
Miserableness	0.4	0.6	1.7	0.5	0.1	-0.4	1.3	-1.3	0.2
Hearing aid user	0.4	0.4	1.5	-1.2	-0.4	0.2	-0.8	0.3	-0.1
Illnesses of father: High blood pressure	0.4	0.5	0.9	0.7	0.5	-0.7	-0.4	-0.9	-0.8
Myopia	0.4	0.6	1.8	1.3	-0.8	0.4	0.2	0.9	0.5
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.9	-0.6	-1.4	0.6	-0.5	-0.6	-0.3
Supplements: Calcium	0.4	0.5	1.3	0.4	0.7	-0.6	0.2	-1.2	0.7
Leg fat mass (left)	0.4	1.7	6.5	1.2	1.3	-2.6	0.6	0.6	-0.1
Intelligence (Savage-Jansen 2018)	0.3	1.1	3.0	1.2	-0.2	-0.3	0.7	1.7	1.2
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.0	0.9	-1.0	0.6	0.8	0.9	-0.4
Crohns Disease (2012)	0.3	0.6	2.1	-0.6	-0.9	0.3	0.0	0.0	-1.5
Schizophrenia (2014)	0.3	0.6	2.8	-0.3	-0.6	-0.6	0.0	1.7	-0.2
Ulcerative Colitis	0.3	0.4	1.3	1.1	-1.0	0.4	0.0	0.0	-0.1
Blood Eosinophil Count	0.3	2.5	7.6	-2.5	-0.4	0.0	-0.8	-2.8	-0.2
Height	0.3	4.8	7.0	-2.6	-2.5	2.6	-2.6	-0.1	1.6
Smoking Status	0.3	0.6	1.0	-0.1	0.9	-1.0	0.2	-0.9	1.0
Hypothyroidism (self reported)	0.3	0.8	2.3	-0.3	-0.4	-1.0	0.6	1.5	0.9
Respiratory disease	0.3	0.8	2.3	-0.6	0.7	-1.5	0.7	-0.7	0.7
Relative age of first facial hair	0.3	0.6	1.6	1.0	-0.4	-0.4	0.5	0.7	-1.3
Vitamin and mineral supplements	0.3	0.5	1.0	0.3	0.6	-0.7	0.1	1.0	0.9
Diabetes (father)	0.3	0.4	0.8	-0.3	0.3	-0.2	-0.9	-0.9	-0.8
Hand grip strength (right)	0.3	0.8	1.8	1.3	0.6	0.1	-0.1	1.1	1.1
Relative age voice broke	0.3	0.5	0.9	1.0	0.4	-0.9	0.4	0.2	-0.8
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.2	0.3	0.1	0.2	1.1	-0.1	0.5
Supplements: Glucosamine	0.3	0.4	0.9	0.9	-0.8	0.6	-0.4	0.3	0.2
Medication: Atenolol	0.3	0.4	1.8	-1.4	-0.1	-0.5	-0.2	-0.1	0.5
High blood pressure (mother)	0.3	0.4	0.6	0.6	-0.2	-0.6	0.8	0.7	-0.7
Past tobacco smoking	0.3	0.6	1.6	0.1	-1.3	1.2	-0.4	0.7	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	2.0	1.4	0.4	-0.2	0.7	0.2	0.4
Had other major operations	0.3	0.4	1.5	0.4	0.4	-0.1	1.2	-0.2	-0.6
Medication: Simvastatin	0.3	0.5	0.9	-0.3	0.5	-0.9	0.9	0.1	0.8
Alcohol intake versus 10 years previously	0.3	0.5	1.9	0.0	0.0	0.9	1.4	-0.4	0.3
Father’s age at death	0.3	0.5	2.3	-0.1	-1.5	0.4	0.1	-0.2	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.8	0.7	1.3	-0.6	0.4	-0.2	-0.0
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.1	0.3	1.0	-1.0	0.5	-0.5	-0.9
Asthma	0.3	0.7	1.6	-0.3	0.4	-1.1	0.6	-1.2	0.7
Arm fat mass (right)	0.3	1.3	4.3	1.3	1.0	-2.1	0.9	0.3	0.2
Breastfed as a baby	0.3	0.3	0.6	0.8	0.2	-0.7	-0.2	-0.6	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	2.0	0.3	1.4	-0.8	0.2	-0.0	-0.1
Forced vital capacity (FVC), Best measure	0.3	1.2	3.9	-0.7	-1.1	2.0	-0.3	0.6	1.1
Body fat percentage	0.3	1.0	3.6	0.6	0.9	-1.9	0.8	0.7	-0.3
Wheeze or whistling in the chest in last year	0.3	0.5	1.1	-0.3	0.6	-0.9	0.7	-1.0	0.2
Qualifications: College or University degree	0.3	0.9	2.8	0.7	0.3	-0.5	1.7	0.1	1.2
Medication: Seretide 50 evohaler	0.3	0.3	0.9	0.9	0.5	0.1	0.4	-0.1	-0.8
Leg fat mass (right)	0.3	1.2	4.8	0.8	1.2	-2.2	0.6	0.3	0.2
Alcohol intake frequency.	0.3	0.7	1.5	0.7	0.9	-1.2	1.1	0.4	-0.1
Comparative height size at age 10	0.3	1.7	3.3	-1.8	-1.4	1.3	-1.1	0.8	1.2
Overall health rating	0.3	0.6	1.8	-1.0	-0.5	-0.2	-0.3	-0.8	1.3
Family relationship satisfaction	0.3	0.4	1.0	-0.7	-0.7	-0.1	-0.4	0.4	-1.0
Arm fat percentage (left)	0.3	1.4	3.7	1.2	0.9	-1.9	1.4	0.5	0.0
Average weekly red wine intake	0.3	0.5	1.7	0.4	0.8	-1.3	-0.6	-0.2	0.3
Loneliness, isolation	0.3	0.5	1.7	0.6	-0.4	-0.2	1.3	0.1	0.7
Asthma (self-reported)	0.3	0.5	1.3	-0.2	0.3	-1.1	0.4	-1.0	0.6
Arm fat mass (left)	0.3	1.3	3.7	1.4	1.0	-1.9	1.0	0.6	0.1
High cholesterol (Self-reported)	0.3	0.5	1.5	-1.2	-0.8	0.2	-0.4	-0.7	0.2
Medication: Paracetamol	0.3	0.5	1.2	-1.0	-1.1	-0.5	0.3	-0.2	0.8
Fractured/broken bones in last 5 years	0.3	0.4	1.6	-0.6	-0.4	1.3	0.0	-0.2	0.1
Age started oral contraceptive pill	0.3	0.4	1.6	0.3	-0.2	0.1	-1.2	0.7	-0.3
Ever depressed for a whole week	0.3	0.4	1.1	0.3	0.4	-0.6	1.0	0.7	-0.3
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.3	-1.1	-0.0	-0.4	0.8	0.4	0.2
Alcohol drinker status: Previous	0.3	0.3	1.0	0.2	1.0	-0.3	-0.5	-0.4	-0.5
Depression (Nagel 2018)	0.2	0.2	0.7	-0.2	-0.8	-0.4	0.6	0.3	0.3
Neuroticism (Nagel 2018)	0.2	0.6	1.7	0.4	-1.3	0.7	0.5	0.0	-0.9
Schizophrenia vs Biploar Disorder	0.2	0.3	1.6	0.5	-0.1	-1.3	0.0	0.0	0.3
Worry (Nagel 2018)	0.2	0.5	1.1	0.5	-1.0	0.8	0.3	0.7	-0.5
Crohns Disease (2017)	0.2	0.5	1.4	-1.2	-0.4	0.0	-0.8	-0.6	0.8
HDL Cholesterol	0.2	0.4	1.9	-0.2	0.5	-0.0	0.0	0.3	-1.4
Lupus	0.2	0.4	0.8	0.3	0.7	0.2	0.8	-0.9	-0.1
Rheumatoid Arthritis	0.2	0.3	1.0	-1.0	0.6	-0.3	0.0	0.0	0.8
Triglycerides	0.2	0.3	1.5	-0.4	-0.4	0.2	0.0	-1.2	-0.1
Waist Hip Ratio (WHR)	0.2	0.7	1.7	0.7	0.8	-0.7	0.2	1.3	0.9
Systolic Blood Pressure	0.2	0.9	3.1	1.8	0.4	-1.2	0.6	0.5	0.3
Medication for hormone replacement therapy	0.2	0.2	0.6	0.8	0.5	-0.6	0.2	-0.2	0.4
Supplements: Zinc	0.2	0.2	0.7	-0.4	-0.1	0.2	0.4	-0.8	-0.2
Trunk fat percentage	0.2	0.7	2.1	0.1	0.7	-1.4	0.8	0.9	-0.2
Average weekly fortified wine intake	0.2	0.2	0.5	0.1	-0.4	0.0	0.7	0.1	0.6
Fed-up feelings	0.2	0.4	1.4	-0.2	-0.2	0.5	-0.5	-1.2	-0.3
Age when periods started (menarche)	0.2	0.5	1.1	1.1	-0.2	-0.2	0.7	0.6	0.9
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.7	-0.5	-0.4	0.8	0.4	-0.8	-0.8
Sitting height	0.2	1.5	3.4	-1.9	-0.2	1.3	-1.7	0.4	1.0
Trunk fat mass	0.2	1.0	2.9	0.7	0.8	-1.7	0.9	1.0	0.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.0	-1.0	-0.4	0.2	0.3	0.3	0.5
Illnesses of siblings	0.2	0.3	0.6	0.0	0.5	-0.1	0.7	-0.8	0.6
Neuroticism score	0.2	0.4	1.4	-0.0	-0.1	0.3	-0.2	-1.0	-1.2
Weight	0.2	1.1	3.3	1.2	1.1	-1.8	0.5	0.3	0.6
Worrier / anxious feelings	0.2	0.4	1.0	-0.0	-0.4	0.9	1.0	-0.1	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	2.7	-0.1	-0.7	1.6	-0.3	0.7	0.6
Standing height	0.2	2.4	5.4	-1.7	-1.6	2.3	-1.5	0.6	1.0
Age at first live birth	0.2	0.4	1.4	-0.1	-0.7	1.2	0.1	0.5	-0.0
Whole body fat mass	0.2	0.9	3.4	0.8	0.8	-1.8	0.6	0.8	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.1	0.2	-1.1	0.4	0.1	-0.4	0.8
Qualifications: nursing, teaching	0.2	0.3	1.1	0.1	-0.7	0.4	1.1	0.5	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.8	-0.5	0.9	0.6	-0.2	0.6	-0.4
Medication for cholesterol	0.2	0.4	0.8	-0.3	-0.7	0.9	-0.1	-0.9	0.4
Mineral and other dietary supplements	0.2	0.2	0.7	-0.4	0.9	-0.2	0.4	-0.1	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.6	-0.6	-0.1	0.5	-1.3	-0.6	0.3
Number of self-reported non-cancer illnesses	0.2	0.4	1.9	-0.2	-0.0	-1.4	0.3	0.7	0.1
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.7	0.6	-0.9	-0.3	-0.3	-0.2	-0.0
Number of operations (self-reported)	0.2	0.3	0.6	-0.8	0.7	-0.3	0.3	0.1	-0.7
Average weekly beer plus cider intake	0.2	0.2	0.6	-0.1	0.7	0.1	-0.4	0.6	-0.5
Cholesterol lowering medication	0.2	0.4	1.0	-0.6	-1.0	-0.1	-0.1	-0.9	-0.0
Heart disease (siblings)	0.2	0.2	0.4	0.7	-0.5	0.3	-0.1	0.5	-0.5
Arm predicted mass (left)	0.2	1.0	3.0	1.2	0.6	-1.7	-0.2	-0.2	1.0
Schizophrenia (2018)	0.1	0.1	0.3	-0.6	-0.6	-0.0	0.0	0.2	0.0
Age at First Birth	0.1	0.2	0.6	-0.2	0.4	-0.8	-0.1	-0.0	0.3
Allergy or Eczema	0.1	0.2	0.7	-0.2	-0.4	0.3	0.8	-0.5	-0.2
Lung FEV1/FVC ratio	0.1	0.6	1.6	0.2	-0.6	1.3	-0.8	-0.2	-0.9
Lung FVC	0.1	0.3	1.2	0.3	-0.3	1.1	-0.4	0.1	0.6
Neuroticism	0.1	0.1	0.5	0.7	-0.0	-0.1	0.4	-0.5	-0.1
Tanning	0.1	1.0	4.0	-0.1	-0.9	2.0	-1.0	0.3	-0.5
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	-0.5	0.2	0.3	-0.1	0.1	0.5
Leg fat-free mass (left)	0.1	0.4	1.0	0.9	-0.2	-0.5	0.2	0.1	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.4	0.2	-0.6	-0.4	0.4	-0.2	-0.0
Leg predicted mass (left)	0.1	0.4	1.1	1.0	-0.2	-0.6	0.3	0.1	1.0
Nervous feelings	0.1	0.3	0.9	1.0	-0.6	0.3	-0.1	0.4	0.1
Hearing difficulty/problems with background noise	0.1	0.2	0.7	-0.2	-0.4	0.0	-0.2	-0.8	0.5
Allergy	0.1	0.3	0.6	0.5	0.8	0.1	-0.1	0.7	-0.4
Medication: Ramipril	0.1	0.2	0.8	-0.9	0.0	-0.0	0.2	-0.4	-0.1
Trunk fat-free mass	0.1	0.7	1.8	1.1	0.1	-0.8	-0.5	0.1	1.3
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.4	-0.5	0.3	0.3	-0.0	0.0	0.6
Trunk predicted mass	0.1	0.7	1.8	1.2	0.0	-0.8	-0.5	0.1	1.4
Peak expiratory flow (PEF)	0.1	0.3	0.6	-0.1	0.3	0.5	-0.8	-0.4	0.5
Medication: Amlodipine	0.1	0.1	0.3	0.1	-0.6	0.3	-0.5	-0.4	-0.0
Arm fat-free mass (right)	0.1	0.4	1.3	1.1	0.2	-0.8	-0.5	0.2	0.5
Neck or shoulder pain in last month	0.1	0.2	0.9	0.2	-0.4	-0.1	0.4	-0.0	-1.0
Medication: Ibuprofen	0.1	0.1	0.3	-0.5	0.1	0.4	-0.0	-0.2	0.1
Arm predicted mass (right)	0.1	0.6	1.5	1.2	0.3	-1.1	-0.4	-0.0	0.8
Whole body fat-free mass	0.1	0.6	1.4	1.1	0.0	-0.9	-0.2	0.2	1.2
Leg fat-free mass (right)	0.1	0.6	2.0	1.4	-0.2	-0.7	0.4	0.4	0.7
Back pain experienced in last month	0.1	0.1	0.5	-0.2	0.1	-0.0	-0.7	-0.5	-0.3
Whole body water mass	0.1	0.6	1.5	1.1	0.1	-0.9	-0.2	0.1	1.2
Leg predicted mass (right)	0.1	0.6	2.0	1.4	-0.2	-0.8	0.4	0.4	0.7
Medication: Lisinopril	0.1	0.2	0.6	-0.5	-0.5	0.1	-0.0	-0.7	0.1
Basal metabolic rate	0.1	0.5	0.9	1.0	0.1	-0.9	-0.2	0.2	1.0
Arm fat-free mass (left)	0.1	0.7	1.8	1.2	0.3	-1.4	-0.5	0.0	0.9
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.8	1.7	0.9	0.6	-0.3	-0.1	1.3	-1.2
Tense / ‘highly strung’	0.0	0.1	0.2	0.4	0.3	-0.2	0.0	0.3	-0.2
Chest pain or discomfort	0.0	0.1	0.2	-0.4	0.2	-0.2	0.0	-0.2	-0.3

Hub : Genes

TMC8

Models

Trait associations