Hub : Genes

TMC8

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1370	0.0460	3.3e-03	0.019	NA	0.015	NA	0.012	1.0e-02	NA	1.8e-02	NA	3.4e-02
2	GTEx	Skin Sun Exposed Lower leg	0.1360	0.0490	7.8e-03	0.003	NA	-0.003	NA	0.001	1.6e-01	NA	8.0e-01	NA	2.4e-01
3	YFS	Blood	0.3156	0.0299	0.0e+00	0.227	0.201	0.240	0.238	0.230	7.2e-73	8.0e-64	1.7e-77	1.4e-76	8.6e-74
4	TCGA	Breast Invasive Carcinoma	0.0525	0.0197	9.3e-05	0.005	0.032	0.033	NA	0.024	3.1e-02	3.2e-07	1.9e-07	NA	7.8e-06
5	TCGA	Brain Lower Grade Glioma	0.1061	0.0366	7.4e-06	0.068	0.055	0.065	NA	0.074	3.9e-08	7.2e-07	7.8e-08	NA	9.4e-09
6	TCGA	Stomach Adenocarcinoma	0.1180	0.0540	3.8e-03	-0.003	0.019	0.004	NA	-0.004	7.6e-01	1.4e-02	1.6e-01	NA	8.9e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.2	1.8	5.5	-0.3	-1.0	0.8	0.0	2.3	-2.0
Bipolar Disorder or Schizophrenia	0.4	1.0	2.8	-0.8	-1.1	0.5	0.0	1.7	-1.2
Depressed Affect (Nagel 2018)	0.4	0.9	3.2	-0.5	-1.8	1.2	0.1	-0.6	-0.5
Depression (Nagel 2018)	0.2	0.2	0.7	-0.2	-0.8	-0.4	0.6	0.3	0.3
Intelligence (Savage-Jansen 2018)	0.3	1.1	3.0	1.2	-0.2	-0.3	0.7	1.7	1.2
Neuroticism (Nagel 2018)	0.2	0.6	1.7	0.4	-1.3	0.7	0.5	0.0	-0.9
Schizophrenia (2018)	0.1	0.1	0.3	-0.6	-0.6	-0.0	0.0	0.2	0.0
Schizophrenia vs Biploar Disorder	0.2	0.3	1.6	0.5	-0.1	-1.3	0.0	0.0	0.3
Worry (Nagel 2018)	0.2	0.5	1.1	0.5	-1.0	0.8	0.3	0.7	-0.5
Alzheimer’s Disease (in mother)	0.9	1.1	2.5	-1.3	-1.6	0.4	-0.1	-0.1	1.5
Alzheimer’s Disease (in father)	2.8	3.0	5.3	-2.3	-0.8	1.8	-1.6	-1.8	-1.7
Alzheimer’s Disease (including proxy)	2.0	2.9	5.8	-2.4	-2.1	1.7	-1.4	-1.4	0.2
Crohns Disease (2017)	0.2	0.5	1.4	-1.2	-0.4	0.0	-0.8	-0.6	0.8
Irritable Bowel Disease (IBD)	0.4	0.9	1.5	-1.1	-1.2	0.9	-0.9	-0.9	0.4
Ulcerative Colitis (UC)	0.6	1.1	3.2	-0.5	-1.8	1.3	-0.6	-1.0	-0.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.4	0.7	1.2	-1.0	1.0	-0.2	-0.9	0.0	-1.1
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.0	0.9	-1.0	0.6	0.8	0.9	-0.4
Breast Cancer	1.4	3.3	9.9	1.8	1.3	0.1	2.1	0.8	3.1
Ovarian Cancer	1.3	1.7	4.6	0.8	0.8	-2.1	0.7	0.7	1.8
Prostate Cancer	0.5	0.8	3.7	0.6	-0.1	0.4	0.4	1.9	0.4
Age at First Birth	0.1	0.2	0.6	-0.2	0.4	-0.8	-0.1	-0.0	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.8	1.7	-0.4	-1.3	1.3	0.0	0.0	-1.3
Coronary Artery Disease (CAD)	0.6	0.7	2.5	-1.6	-0.1	1.2	0.0	0.0	0.2
Crohns Disease (2012)	0.3	0.6	2.1	-0.6	-0.9	0.3	0.0	0.0	-1.5
Mean Putamen Volume	1.1	1.3	3.3	-0.5	-1.8	0.8	-1.0	0.0	-1.5
Fasting Glucose	0.4	0.4	2.0	-0.4	-0.4	0.1	-0.5	-1.4	-0.1
HbA1C	2.5	2.7	8.2	1.4	1.2	-0.2	1.5	2.9	-1.6
HDL Cholesterol	0.2	0.4	1.9	-0.2	0.5	-0.0	0.0	0.3	-1.4
LDL Cholesterol	0.8	1.2	3.1	0.1	-1.0	1.5	0.0	1.1	-1.8
Lupus	0.2	0.4	0.8	0.3	0.7	0.2	0.8	-0.9	-0.1
Neuroticism (2016)	0.4	0.5	1.1	1.1	0.3	-0.5	1.0	-0.7	0.5
Primary Biliary Cirrhosis	0.5	0.7	2.3	0.4	-0.5	1.1	-0.7	0.0	-1.5
Rheumatoid Arthritis	0.2	0.3	1.0	-1.0	0.6	-0.3	0.0	0.0	0.8
Schizophrenia (2014)	0.3	0.6	2.8	-0.3	-0.6	-0.6	0.0	1.7	-0.2
Triglycerides	0.2	0.3	1.5	-0.4	-0.4	0.2	0.0	-1.2	-0.1
Type 2 Diabetes (T2D) (2012)	0.6	0.6	2.2	-0.1	-0.8	1.5	0.0	0.0	-1.0
Ulcerative Colitis	0.3	0.4	1.3	1.1	-1.0	0.4	0.0	0.0	-0.1
Blood Eosinophil Count	0.3	2.5	7.6	-2.5	-0.4	0.0	-0.8	-2.8	-0.2
Blood Platelet Count	0.6	7.1	18.3	0.0	3.0	-1.3	1.6	-4.3	3.4
Blood Red Count	3.9	37.8	141.6	4.5	-3.4	1.1	2.2	11.9	-6.9
Blood White Count	0.4	2.7	8.2	-0.9	-0.3	1.1	-1.4	-2.9	-1.9
Heel T-Score	0.7	5.3	11.6	-0.3	1.4	-1.1	-3.3	-2.5	-3.4
BMI	0.5	2.6	7.8	1.5	2.2	-2.8	0.4	-0.7	-0.0
Height	0.3	4.8	7.0	-2.6	-2.5	2.6	-2.6	-0.1	1.6
Waist Hip Ratio (WHR)	0.2	0.7	1.7	0.7	0.8	-0.7	0.2	1.3	0.9
Systolic Blood Pressure	0.2	0.9	3.1	1.8	0.4	-1.2	0.6	0.5	0.3
Smoking Status	0.3	0.6	1.0	-0.1	0.9	-1.0	0.2	-0.9	1.0
Allergy or Eczema	0.1	0.2	0.7	-0.2	-0.4	0.3	0.8	-0.5	-0.2
Cardiovascular Disease	0.4	1.4	3.0	1.7	0.9	-1.6	0.8	0.5	1.0
Hypothyroidism (self reported)	0.3	0.8	2.3	-0.3	-0.4	-1.0	0.6	1.5	0.9
Respiratory disease	0.3	0.8	2.3	-0.6	0.7	-1.5	0.7	-0.7	0.7
Type 2 Diabetes (T2D) (2018)	1.2	2.2	5.5	1.2	1.9	-2.3	1.3	-0.7	0.5
Lung FEV1/FVC ratio	0.1	0.6	1.6	0.2	-0.6	1.3	-0.8	-0.2	-0.9
Lung FVC	0.1	0.3	1.2	0.3	-0.3	1.1	-0.4	0.1	0.6
Neuroticism	0.1	0.1	0.5	0.7	-0.0	-0.1	0.4	-0.5	-0.1
Chronotype (morning person)	0.8	1.8	5.2	-0.6	0.9	0.6	-1.7	-1.1	-2.3
Hair Pigment	0.0	0.8	1.7	0.9	0.6	-0.3	-0.1	1.3	-1.2
Tanning	0.1	1.0	4.0	-0.1	-0.9	2.0	-1.0	0.3	-0.5
Hand grip strength (left)	0.4	0.9	1.8	1.3	-0.3	0.8	0.1	1.4	1.2
Number of treatments/medications taken	1.2	2.2	7.6	0.6	1.4	-2.8	1.1	-0.3	1.4
Average weekly spirits intake	1.1	1.4	4.0	1.6	2.0	-0.7	0.9	0.3	0.3
Sensitivity / hurt feelings	0.5	0.8	3.7	0.8	-0.1	-0.6	-0.3	0.0	-1.9
Frequency of depressed mood in last 2 weeks	1.0	1.4	4.0	1.3	1.1	-2.0	0.3	-0.2	1.1
Hearing difficulty/problems: Yes	0.5	0.7	1.7	1.2	0.3	-0.7	0.6	0.4	1.3
Relative age of first facial hair	0.3	0.6	1.6	1.0	-0.4	-0.4	0.5	0.7	-1.3
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	4.4	0.0	0.3	0.0	2.1	0.2	1.2
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.9	0.4	0.4	-0.5	-1.4	-0.5	-0.7
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	-0.5	0.2	0.3	-0.1	0.1	0.5
Systolic blood pressure, automated reading	0.5	1.4	4.1	1.5	1.0	-2.0	0.3	1.0	0.1
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	3.3	-0.1	1.2	-0.4	1.8	-0.1	1.5
Angina	0.6	0.8	2.4	-0.1	-0.3	-0.5	1.4	-0.6	1.5
Medication for hormone replacement therapy	0.2	0.2	0.6	0.8	0.5	-0.6	0.2	-0.2	0.4
Vitamin and mineral supplements	0.3	0.5	1.0	0.3	0.6	-0.7	0.1	1.0	0.9
Supplements: Zinc	0.2	0.2	0.7	-0.4	-0.1	0.2	0.4	-0.8	-0.2
Medication: Co-codamol	0.5	0.6	1.5	-1.2	-0.2	0.3	-1.0	0.8	0.4
Medication: Metformin	1.2	1.7	5.9	1.0	1.7	-2.4	0.2	-0.7	0.1
Diabetes (father)	0.3	0.4	0.8	-0.3	0.3	-0.2	-0.9	-0.9	-0.8
Diabetes (mother)	0.7	0.8	1.5	-0.1	0.6	-0.9	-1.1	-1.2	1.2
Severe depression (siblings)	0.6	0.6	1.1	-0.8	-1.1	0.3	-1.1	0.4	-0.7
Pack years adult smoking proportion	1.6	2.4	5.0	-0.3	1.7	-2.2	1.2	-0.7	2.1
Impedance of leg (right)	0.7	3.5	10.9	-3.3	-0.8	2.2	-2.0	-0.8	-0.5
Leg fat-free mass (left)	0.1	0.4	1.0	0.9	-0.2	-0.5	0.2	0.1	1.0
Trunk fat percentage	0.2	0.7	2.1	0.1	0.7	-1.4	0.8	0.9	-0.2
Hand grip strength (right)	0.3	0.8	1.8	1.3	0.6	0.1	-0.1	1.1	1.1
Townsend deprivation index at recruitment	2.9	4.0	6.6	2.4	2.4	-2.6	1.9	1.2	1.1
Current tobacco smoking	0.6	1.1	4.5	0.3	0.4	-0.3	1.1	-0.6	2.1
Average weekly fortified wine intake	0.2	0.2	0.5	0.1	-0.4	0.0	0.7	0.1	0.6
Maternal smoking around birth	1.4	2.0	4.0	-0.6	-0.0	0.4	-1.8	-2.0	-2.0
Fed-up feelings	0.2	0.4	1.4	-0.2	-0.2	0.5	-0.5	-1.2	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.4	0.2	-0.6	-0.4	0.4	-0.2	-0.0
Relative age voice broke	0.3	0.5	0.9	1.0	0.4	-0.9	0.4	0.2	-0.8
Taking other prescription medications	0.9	1.4	5.5	0.2	0.7	-2.3	0.5	-0.3	1.4
Age when periods started (menarche)	0.2	0.5	1.1	1.1	-0.2	-0.2	0.7	0.6	0.9
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	5.2	-2.3	-0.3	0.8	-1.4	-1.1	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.5	-0.5	1.1	-1.6	-0.8	-0.7	-0.5
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.2	0.3	0.1	0.2	1.1	-0.1	0.5
Qualifications: CSEs or equivalent	1.1	1.5	3.5	1.9	1.8	-1.0	0.7	0.8	-0.4
Serious illness, injury or assault to yourself	0.8	1.0	2.2	-1.0	-0.5	0.8	-0.8	-1.5	1.1
High blood pressure	0.5	1.5	4.1	1.3	0.4	-2.0	1.3	1.0	0.5
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.7	-0.5	-0.4	0.8	0.4	-0.8	-0.8
Multivitamins +/- minerals	0.4	0.5	2.0	0.6	0.1	0.4	0.6	-0.1	-1.4
Stomach or abdominal pain in last month	0.4	0.5	1.1	-0.5	-0.9	1.0	-0.7	-0.6	0.3
Supplements: Glucosamine	0.3	0.4	0.9	0.9	-0.8	0.6	-0.4	0.3	0.2
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	5.1	0.6	0.1	0.4	0.1	0.4	-2.3
Medication: Atenolol	0.3	0.4	1.8	-1.4	-0.1	-0.5	-0.2	-0.1	0.5
Medication: Levothyroxine sodium	0.4	0.7	2.3	-0.4	0.1	-1.2	-0.0	1.5	-0.4
Sitting height	0.2	1.5	3.4	-1.9	-0.2	1.3	-1.7	0.4	1.0
Chronic bronchitis/emphysema (father)	0.4	0.5	0.7	0.8	0.8	-0.7	0.6	0.3	0.8
High blood pressure (mother)	0.3	0.4	0.6	0.6	-0.2	-0.6	0.8	0.7	-0.7
Body mass index (BMI)	0.7	3.1	8.9	2.1	1.9	-3.0	1.2	0.1	0.1
Impedance of leg (left)	0.5	2.5	7.3	-2.7	-0.6	1.5	-2.0	-0.1	-1.2
Leg predicted mass (left)	0.1	0.4	1.1	1.0	-0.2	-0.6	0.3	0.1	1.0
Trunk fat mass	0.2	1.0	2.9	0.7	0.8	-1.7	0.9	1.0	0.3
Waist circumference	0.9	3.1	8.5	1.9	1.8	-2.9	1.3	0.7	1.1
Number of incorrect matches in round	0.5	0.9	3.7	-0.8	-1.9	0.2	-0.9	0.3	-0.0
Past tobacco smoking	0.3	0.6	1.6	0.1	-1.3	1.2	-0.4	0.7	0.1
Alcohol usually taken with meals	0.7	1.2	2.9	1.7	0.2	0.8	1.4	1.2	0.2
Nervous feelings	0.1	0.3	0.9	1.0	-0.6	0.3	-0.1	0.4	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	2.0	1.4	0.4	-0.2	0.7	0.2	0.4
Hearing difficulty/problems with background noise	0.1	0.2	0.7	-0.2	-0.4	0.0	-0.2	-0.8	0.5
Hair/balding pattern: Pattern 2	0.6	0.8	2.3	-0.1	1.5	-0.3	0.2	-1.0	1.1
Had menopause	0.4	0.5	1.1	0.7	0.2	-0.4	0.5	0.9	-1.0
Had other major operations	0.3	0.4	1.5	0.4	0.4	-0.1	1.2	-0.2	-0.6
Forced vital capacity (FVC)	0.4	1.7	5.2	-1.4	-0.7	2.3	-1.1	-0.1	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	3.3	1.2	1.8	-1.8	1.4	1.0	-0.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.0	-1.0	-0.4	0.2	0.3	0.3	0.5
Qualifications: None of the above	0.4	0.8	2.2	-1.4	-1.5	-0.1	-0.5	0.0	0.4
Financial difficulties in last 2 years	0.6	0.8	1.4	-0.9	-0.9	0.9	1.2	0.9	0.2
Mouth/teeth dental problems	1.1	1.6	6.5	-0.2	-1.1	0.6	-1.3	-2.5	-0.3
Heart attack	0.4	0.5	1.3	-1.1	0.3	-0.4	1.0	0.5	0.1
Allergy	0.1	0.3	0.6	0.5	0.8	0.1	-0.1	0.7	-0.4
Pain all over the body in last month	0.7	0.7	3.8	-0.2	-0.3	-0.5	-0.2	1.9	-0.4
Diabetes (self-reported)	1.0	1.5	4.1	1.6	1.2	-2.0	0.6	-0.4	0.8
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.3	1.1	1.1	-1.0	0.8	-0.3	-0.3
Medication: Ramipril	0.1	0.2	0.8	-0.9	0.0	-0.0	0.2	-0.4	-0.1
Medication: Simvastatin	0.3	0.5	0.9	-0.3	0.5	-0.9	0.9	0.1	0.8
Fluid intelligence score	1.2	2.5	5.5	-1.2	-2.4	2.1	-1.0	-1.0	-1.3
Illnesses of siblings	0.2	0.3	0.6	0.0	0.5	-0.1	0.7	-0.8	0.6
Neuroticism score	0.2	0.4	1.4	-0.0	-0.1	0.3	-0.2	-1.0	-1.2
Weight	0.2	1.1	3.3	1.2	1.1	-1.8	0.5	0.3	0.6
Impedance of arm (right)	0.4	1.9	5.2	-2.3	-1.2	2.1	-0.4	0.0	0.5
Arm fat percentage (right)	0.5	2.0	6.1	1.4	1.2	-2.5	1.4	0.2	0.4
Trunk fat-free mass	0.1	0.7	1.8	1.1	0.1	-0.8	-0.5	0.1	1.3
Hip circumference	0.4	1.8	5.5	1.3	1.4	-2.3	0.8	-0.2	1.2
Time employed in main current job	0.6	0.7	3.2	0.4	0.1	0.8	-0.1	1.8	0.1
Alcohol intake versus 10 years previously	0.3	0.5	1.9	0.0	0.0	0.9	1.4	-0.4	0.3
Father’s age at death	0.3	0.5	2.3	-0.1	-1.5	0.4	0.1	-0.2	-0.4
Worrier / anxious feelings	0.2	0.4	1.0	-0.0	-0.4	0.9	1.0	-0.1	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.8	0.7	1.3	-0.6	0.4	-0.2	-0.0
Falls in the last year	0.6	0.8	2.2	-0.3	0.4	-1.0	-0.3	-1.2	1.5
Hair/balding pattern: Pattern 3	0.5	0.7	2.0	0.3	0.7	-1.4	-0.5	-1.2	-0.4
Number of live births	1.6	2.3	6.9	-0.8	-1.2	0.4	-2.6	-2.1	-0.5
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	4.8	-0.9	-0.7	2.2	-1.1	0.1	0.8
Pulse rate	1.1	1.8	5.1	1.3	2.2	-1.5	1.1	-0.0	-0.9
Happiness	0.7	0.9	2.2	0.3	-1.3	0.5	-0.3	1.5	-1.0
Noisy workplace	4.7	5.7	13.8	2.4	1.3	-1.5	3.7	2.5	2.2
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.1	0.3	1.0	-1.0	0.5	-0.5	-0.9
Serious illness, injury or assault of a close relative in last 2 years	2.8	3.2	5.2	-1.4	-2.3	1.8	-1.6	-1.7	-1.9
Mouth/teeth dental problems: Dentures	1.1	1.9	6.0	0.7	-0.3	-1.5	1.6	2.4	0.2
Asthma	0.3	0.7	1.6	-0.3	0.4	-1.1	0.6	-1.2	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.4	-0.5	0.3	0.3	-0.0	0.0	0.6
Medication: Cholesterol lowering	0.9	1.4	2.7	-0.7	1.5	-1.6	0.8	-0.9	1.2
Depression (self-reported)	0.8	1.0	2.7	0.1	1.0	-1.2	0.9	0.3	1.7
Medication: Lansoprazole	0.6	0.7	1.5	-0.8	-0.1	-0.9	0.9	1.2	0.4
Prospective memory result	2.0	2.4	3.3	1.8	1.4	-1.7	1.6	1.7	0.9
Lung cancer (father)	1.0	1.2	2.1	1.1	1.4	-0.8	1.4	0.5	1.0
Illnesses of mother	0.6	0.7	2.7	0.3	0.9	-0.6	-0.7	-1.6	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	2.7	-0.1	-0.7	1.6	-0.3	0.7	0.6
Pulse wave Arterial Stiffness index	0.6	0.7	2.9	0.7	0.4	-0.3	0.3	1.7	0.7
Impedance of arm (left)	0.8	3.7	9.7	-2.9	-1.7	3.1	-0.8	0.5	-0.5
Arm fat mass (right)	0.3	1.3	4.3	1.3	1.0	-2.1	0.9	0.3	0.2
Trunk predicted mass	0.1	0.7	1.8	1.2	0.0	-0.8	-0.5	0.1	1.4
Standing height	0.2	2.4	5.4	-1.7	-1.6	2.3	-1.5	0.6	1.0
Length of working week for main job	0.5	0.6	1.6	1.2	1.3	-0.2	0.1	-0.5	-0.2
Exposure to tobacco smoke at home	0.4	0.5	1.3	-0.3	0.5	-1.1	-0.3	-1.1	-0.3
Breastfed as a baby	0.3	0.3	0.6	0.8	0.2	-0.7	-0.2	-0.6	0.7
Tense / ‘highly strung’	0.0	0.1	0.2	0.4	0.3	-0.2	0.0	0.3	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	2.0	0.3	1.4	-0.8	0.2	-0.0	-0.1
Hair/balding pattern: Pattern 4	0.8	2.1	5.4	2.3	-0.2	0.4	1.7	1.3	1.4
Birth weight of first child	0.4	0.7	2.6	-1.6	0.5	0.5	-0.6	-0.8	-0.6
Peak expiratory flow (PEF)	0.1	0.3	0.6	-0.1	0.3	0.5	-0.8	-0.4	0.5
Pulse wave reflection index	0.4	0.4	1.5	0.8	-0.0	-0.0	0.6	0.2	1.2
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.5	-1.0	-0.4	0.3	-1.6	-1.4	-0.9
Loud music exposure frequency	1.0	1.1	2.7	-0.1	-0.7	1.5	-1.0	-0.2	-1.6
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.0	-0.5	0.0	0.6	-1.0	-0.3	-1.4
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	2.0	-0.7	-0.0	0.9	0.9	1.4	-0.3
Blood clot in the leg (DVT)	0.7	0.9	2.7	-0.0	-1.5	-0.1	0.4	0.6	1.6
Medication: Paracetamol	0.4	0.7	1.3	-0.4	-0.7	-1.1	0.9	0.3	1.1
Headache pain in last month	0.8	1.3	2.7	-1.6	-1.6	0.1	0.3	-0.3	1.6
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	4.5	1.5	-0.6	1.3	0.2	2.1	-1.0
Glaucoma (self-reported)	0.7	0.8	3.1	0.3	1.1	0.3	-0.0	1.8	-0.5
Gout (self-reported)	1.5	2.1	6.7	0.5	0.8	-1.0	1.9	0.7	2.6
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	4.4	0.5	-0.4	-1.1	0.8	2.1	0.6
Medication: Amlodipine	0.1	0.1	0.3	0.1	-0.6	0.3	-0.5	-0.4	-0.0
Medication: Ventolin 100micrograms inhaler	2.5	3.2	8.8	1.5	3.0	-2.6	0.7	0.1	1.0
Birth weight	2.0	4.4	7.7	-2.8	-2.6	1.8	-2.2	-1.4	-1.4
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.5	-0.9	-1.6	1.2	-0.5	0.1	-0.5
High blood pressure (siblings)	0.4	0.6	2.0	0.2	-0.1	0.3	-0.3	1.4	-1.1
Forced vital capacity (FVC), Best measure	0.3	1.2	3.9	-0.7	-1.1	2.0	-0.3	0.6	1.1
Body fat percentage	0.3	1.0	3.6	0.6	0.9	-1.9	0.8	0.7	-0.3
Leg fat percentage (right)	0.5	2.0	6.9	0.8	1.8	-2.6	0.9	0.4	0.1
Arm fat-free mass (right)	0.1	0.4	1.3	1.1	0.2	-0.8	-0.5	0.2	0.5
Exposure to tobacco smoke outside home	0.4	0.5	2.3	0.2	-0.5	0.5	1.5	-0.3	-0.4
Comparative body size at age 10	0.7	1.8	5.6	1.3	-0.4	-0.0	2.4	1.1	1.4
Number of full brothers	1.1	1.4	3.6	0.2	-1.9	1.3	-1.4	-0.6	-0.9
Worry too long after embarrassment	0.4	0.6	1.8	-0.2	-0.6	0.7	-0.4	-1.0	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	2.2	-1.1	0.6	-0.4	0.4	-1.5	0.4
Wheeze or whistling in the chest in last year	0.3	0.5	1.1	-0.3	0.6	-0.9	0.7	-1.0	0.2
Number of children fathered	0.9	1.0	5.8	-2.4	-0.1	0.1	-0.1	0.1	0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	3.1	-0.2	-0.1	0.3	-1.1	-0.2	-1.8
Age at first live birth	0.2	0.4	1.4	-0.1	-0.7	1.2	0.1	0.5	-0.0
Pulse wave peak to peak time	0.5	0.6	1.9	-0.8	-0.5	0.5	-0.4	-1.4	-0.6
Health satisfaction	0.7	0.9	1.6	0.6	0.3	-1.1	1.2	1.3	0.7
Shortness of breath walking on level ground	0.6	0.7	1.9	0.4	0.5	-1.4	1.0	0.8	0.4
Qualifications: College or University degree	0.3	0.9	2.8	0.7	0.3	-0.5	1.7	0.1	1.2
Eye problems/disorders: None of the above	0.4	0.4	1.1	-0.2	-1.0	-0.3	-1.0	0.0	-0.5
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.2	0.4	1.5	-1.2	0.4	-0.5	0.7
Emphysema/chronic bronchitis	0.5	0.5	1.3	-0.9	0.4	-1.2	-0.8	-0.1	0.6
Medication for pain relief, constipation, heartburn	1.0	1.6	3.6	-0.9	-0.4	1.5	-1.9	-1.1	-1.3
Neck or shoulder pain in last month	0.1	0.2	0.9	0.2	-0.4	-0.1	0.4	-0.0	-1.0
Medication: Blood pressure	1.0	1.7	5.9	-1.7	-0.6	-0.1	-0.8	-2.4	0.5
Angina (self-reported)	0.6	0.8	2.3	0.0	0.0	-0.6	1.4	-0.5	1.5
Migraine (self-reported)	0.5	0.6	1.7	-1.1	0.0	-1.3	-0.8	0.2	-0.3
Medication: Ibuprofen	0.1	0.1	0.3	-0.5	0.1	0.4	-0.0	-0.2	0.1
Medication: Allopurinol	0.6	0.8	2.6	0.4	0.4	0.3	0.9	0.8	1.6
Medication: Omeprazole	0.7	0.8	1.9	-0.9	-1.4	0.7	-1.0	-0.5	-0.5
Medication: Seretide 50 evohaler	0.3	0.3	0.9	0.9	0.5	0.1	0.4	-0.1	-0.8
Mean time to correctly identify matches	0.4	0.8	1.7	-1.3	0.9	-0.5	-1.2	0.2	-0.9
Heart disease (mother)	2.2	2.6	7.3	1.3	0.2	-0.7	2.2	2.7	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.1	0.6	-0.5	-0.7	-0.4	0.9	-1.0
Whole body fat mass	0.2	0.9	3.4	0.8	0.8	-1.8	0.6	0.8	0.2
Leg fat mass (right)	0.3	1.2	4.8	0.8	1.2	-2.2	0.6	0.3	0.2
Arm predicted mass (right)	0.1	0.6	1.5	1.2	0.3	-1.1	-0.4	-0.0	0.8
Pulse rate, automated reading	1.0	3.1	9.6	1.7	0.4	-0.9	3.1	2.3	0.0
Alcohol intake frequency.	0.3	0.7	1.5	0.7	0.9	-1.2	1.1	0.4	-0.1
Comparative height size at age 10	0.3	1.7	3.3	-1.8	-1.4	1.3	-1.1	0.8	1.2
Number of full sisters	0.5	0.7	2.8	-0.9	-0.1	-0.6	-0.0	-1.7	0.0
Suffer from ‘nerves’	0.8	1.2	2.3	1.5	1.2	-1.1	1.5	0.6	0.1
Overall health rating	0.3	0.6	1.8	-1.0	-0.5	-0.2	-0.3	-0.8	1.3
Chest pain or discomfort	0.0	0.1	0.2	-0.4	0.2	-0.2	0.0	-0.2	-0.3
Had major operations	1.5	1.8	4.5	-1.4	-2.1	0.7	0.4	1.6	-0.9
Age at last live birth	0.8	1.1	3.1	-0.4	-1.8	1.1	-1.2	-0.9	-0.1
Family relationship satisfaction	0.3	0.4	1.0	-0.7	-0.7	-0.1	-0.4	0.4	-1.0
Leg pain on walking	0.4	0.5	1.8	-0.2	0.1	-1.3	-0.1	0.6	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.0	1.0	0.9	0.3	-0.4	0.8	-0.9
Commuting to job workplace: Car/motor vehicle	1.1	1.2	2.6	-1.3	-0.2	1.0	-1.6	-1.4	-0.2
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	3.0	1.7	1.2	-1.1	0.2	1.4	-0.8
Medication: Aspirin	2.5	3.3	9.5	1.3	1.5	-2.1	3.1	0.8	1.1
Supplements: Vitamin C	1.9	2.2	5.7	-1.0	-0.7	1.4	-2.4	-2.0	-0.2
Knee pain experienced in last month	0.6	0.9	1.8	1.3	0.1	-0.7	1.3	-0.5	-1.0
Hypertension (Self-reported)	0.5	1.3	2.9	1.0	0.5	-1.7	1.4	1.2	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	3.0	0.2	-0.3	0.2	0.1	0.8	1.7
Illnesses of father: Heart disease	2.0	2.8	7.8	0.7	-1.8	1.6	1.5	2.8	-0.9
Illnesses of siblings: Diabetes	1.0	1.2	3.7	0.4	0.5	-1.9	-0.4	-1.3	1.1
Smoking status: Previous	0.6	0.9	2.4	0.4	1.5	-1.4	-0.0	-0.1	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.1	0.2	-1.1	0.4	0.1	-0.4	0.8
Whole body fat-free mass	0.1	0.6	1.4	1.1	0.0	-0.9	-0.2	0.2	1.2
Leg fat-free mass (right)	0.1	0.6	2.0	1.4	-0.2	-0.7	0.4	0.4	0.7
Arm fat percentage (left)	0.3	1.4	3.7	1.2	0.9	-1.9	1.4	0.5	0.0
Average weekly red wine intake	0.3	0.5	1.7	0.4	0.8	-1.3	-0.6	-0.2	0.3
Handedness (chirality/laterality): Left-handed	0.8	0.9	3.8	-0.5	0.2	0.8	0.6	1.9	0.7
Mood swings	0.5	0.9	4.1	1.2	-0.1	0.1	-0.1	-0.4	-2.0
Loneliness, isolation	0.3	0.5	1.7	0.6	-0.4	-0.2	1.3	0.1	0.7
Long-standing illness, disability or infirmity	1.2	1.8	4.8	0.9	1.2	-2.2	1.6	-0.2	1.1
Ever had bowel cancer screening	0.8	0.9	2.7	-1.6	-0.2	0.0	-1.6	0.1	0.2
Diabetes diagnosed by doctor	1.4	2.3	5.2	1.6	2.2	-2.3	0.6	-0.6	0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.5	-1.0	-1.9	1.3	-0.4	1.1	-1.0
Friendships satisfaction	0.8	0.9	3.6	-0.6	-1.9	0.6	-0.5	0.5	-1.0
Qualifications: nursing, teaching	0.2	0.3	1.1	0.1	-0.7	0.4	1.1	0.5	-0.0
Commuting to job workplace: Walk	2.3	2.4	5.8	0.2	1.0	-2.1	2.4	-0.7	1.7
Eye problems/disorders: Cataract	0.6	0.6	3.5	0.2	0.2	0.5	1.9	0.2	0.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.8	-0.5	0.9	0.6	-0.2	0.6	-0.4
Medication for cholesterol	0.2	0.4	0.8	-0.3	-0.7	0.9	-0.1	-0.9	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.8	-0.3	-1.2	0.6	-0.6	1.3	0.1
Back pain experienced in last month	0.1	0.1	0.5	-0.2	0.1	-0.0	-0.7	-0.5	-0.3
Mineral and other dietary supplements	0.2	0.2	0.7	-0.4	0.9	-0.2	0.4	-0.1	-0.5
Breast cancer (self-reported)	0.6	0.7	2.1	0.6	-1.1	0.1	1.4	-0.6	-0.3
Asthma (self-reported)	0.3	0.5	1.3	-0.2	0.3	-1.1	0.4	-1.0	0.6
Osteoporosis (self-reported)	0.5	0.6	2.8	-0.0	0.2	-0.5	0.7	0.5	1.7
Osteoarthritis (self-reported)	0.5	0.6	2.4	0.4	-0.6	0.4	0.8	1.6	0.0
Medication: Aspirin	2.0	2.6	8.4	0.9	1.2	-1.8	2.9	0.4	1.1
Medication: Gliclazide	0.9	1.0	2.2	0.9	1.0	-1.5	-0.7	-1.0	0.8
Illnesses of father: None of the above (group 1)	0.9	1.1	3.7	-0.5	1.1	-0.1	-1.9	-1.1	0.6
Smoking status: Current	0.5	0.8	3.2	0.2	0.3	-0.3	1.0	-0.5	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.6	-0.6	-0.1	0.5	-1.3	-0.6	0.3
Whole body water mass	0.1	0.6	1.5	1.1	0.1	-0.9	-0.2	0.1	1.2
Leg predicted mass (right)	0.1	0.6	2.0	1.4	-0.2	-0.8	0.4	0.4	0.7
Arm fat mass (left)	0.3	1.3	3.7	1.4	1.0	-1.9	1.0	0.6	0.1
Number of self-reported non-cancer illnesses	0.2	0.4	1.9	-0.2	-0.0	-1.4	0.3	0.7	0.1
Average weekly champagne plus white wine intake	1.1	1.4	4.0	-0.1	-1.2	2.0	-0.7	0.8	-1.5
Miserableness	0.4	0.6	1.7	0.5	0.1	-0.4	1.3	-1.3	0.2
Guilty feelings	0.7	1.1	3.1	0.5	1.3	-1.1	1.8	0.7	-0.3
Wears glasses or contact lenses	1.7	2.0	4.6	2.1	1.0	-1.1	1.1	0.5	1.9
Ever taken oral contraceptive pill	0.5	0.5	2.2	0.4	0.6	0.4	0.6	1.5	-0.2
Hearing aid user	0.4	0.4	1.5	-1.2	-0.4	0.2	-0.8	0.3	-0.1
Mother’s age at death	0.6	0.7	1.8	0.0	1.3	-1.0	-0.8	0.1	1.0
Financial situation satisfaction	1.0	1.3	4.6	1.4	-0.2	0.7	0.6	2.1	-0.4
Tinnitus: Yes, now most or all of the time	0.9	1.1	1.6	-0.9	-1.3	1.2	-0.0	0.9	-1.3
Commuting to job workplace: Public transport	1.0	1.2	2.9	1.4	1.7	-1.1	0.7	0.1	0.8
Eye problems/disorders: Glaucoma	0.8	0.9	4.0	0.5	0.5	0.7	0.7	2.0	-0.4
Medication: Blood pressure	0.8	1.6	2.9	1.2	1.3	-1.5	1.1	1.7	-0.2
Pain type(s) experienced in last month: Hip pain	1.1	1.3	2.7	1.6	1.2	-1.6	-0.3	1.0	0.7
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.7	0.6	-0.9	-0.3	-0.3	-0.2	-0.0
High cholesterol (Self-reported)	0.3	0.5	1.5	-1.2	-0.8	0.2	-0.4	-0.7	0.2
Medication: Bendroflumethiazide	1.1	1.6	3.5	1.2	-0.4	-1.4	1.3	1.9	-0.9
Medication: Paracetamol	0.3	0.5	1.2	-1.0	-1.1	-0.5	0.3	-0.2	0.8
Medication: Lisinopril	0.1	0.2	0.6	-0.5	-0.5	0.1	-0.0	-0.7	0.1
Medication: Atorvastatin	0.8	1.0	2.8	-0.4	1.1	-1.1	-0.7	-1.7	-0.1
Illnesses of father: High blood pressure	0.4	0.5	0.9	0.7	0.5	-0.7	-0.4	-0.9	-0.8
Alcohol drinker status: Never	0.7	0.9	2.0	-1.0	0.4	-1.2	-0.6	-0.6	-1.4
Ever smoked	0.7	1.3	3.3	-0.3	1.4	-1.3	0.2	-1.8	0.9
Basal metabolic rate	0.1	0.5	0.9	1.0	0.1	-0.9	-0.2	0.2	1.0
Leg fat percentage (left)	0.8	2.9	10.5	1.3	1.9	-3.2	0.9	0.7	-0.4
Arm fat-free mass (left)	0.1	0.7	1.8	1.2	0.3	-1.4	-0.5	0.0	0.9
Number of operations (self-reported)	0.2	0.3	0.6	-0.8	0.7	-0.3	0.3	0.1	-0.7
Average weekly beer plus cider intake	0.2	0.2	0.6	-0.1	0.7	0.1	-0.4	0.6	-0.5
Irritability	0.5	0.8	3.7	-0.5	-0.0	0.5	-0.3	-0.5	-1.9
Risk taking	0.5	0.7	1.6	-1.0	0.1	1.2	0.3	-1.3	-0.3
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.6	-1.3	-1.0	-0.0	-0.9	-0.5	-0.2
Fractured/broken bones in last 5 years	0.3	0.4	1.6	-0.6	-0.4	1.3	0.0	-0.2	0.1
Age started oral contraceptive pill	0.3	0.4	1.6	0.3	-0.2	0.1	-1.2	0.7	-0.3
Diastolic blood pressure, automated reading	0.6	1.8	4.1	1.3	0.7	-1.9	0.9	2.0	-0.6
Ever depressed for a whole week	0.3	0.4	1.1	0.3	0.4	-0.6	1.0	0.7	-0.3
Unable to work because of sickness or disability	2.3	3.0	7.2	1.5	2.7	-2.4	1.4	-0.0	0.9
Commuting to job workplace: Cycle	1.3	1.6	2.7	-1.2	-1.0	1.5	-1.3	-0.6	-1.6
Myopia	0.4	0.6	1.8	1.3	-0.8	0.4	0.2	0.9	0.5
Vascular/heart problems diagnosed by doctor	0.7	1.8	4.0	-1.2	-0.3	2.0	-1.8	-1.2	-0.7
Cholesterol lowering medication	0.2	0.4	1.0	-0.6	-1.0	-0.1	-0.1	-0.9	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.9	-0.6	-1.4	0.6	-0.5	-0.6	-0.3
Pain experienced in last month	1.0	1.6	3.2	1.8	1.8	-0.3	0.9	1.4	0.7
Supplements: Calcium	0.4	0.5	1.3	0.4	0.7	-0.6	0.2	-1.2	0.7
Basal cell carcinoma (self-reported)	1.5	1.8	3.4	-1.9	-1.3	1.4	-1.1	0.4	-1.4
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.3	-1.1	-0.0	-0.4	0.8	0.4	0.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.8	2.8	-0.2	-1.4	0.0	0.2	0.6	1.7
Heart disease (siblings)	0.2	0.2	0.4	0.7	-0.5	0.3	-0.1	0.5	-0.5
Alcohol drinker status: Previous	0.3	0.3	1.0	0.2	1.0	-0.3	-0.5	-0.4	-0.5
Pack years of smoking	1.6	2.3	6.1	-0.3	1.7	-2.5	1.1	-0.3	1.8
Impedance of whole body	0.7	3.4	10.5	-3.2	-1.3	2.5	-1.3	0.1	-0.7
Leg fat mass (left)	0.4	1.7	6.5	1.2	1.3	-2.6	0.6	0.6	-0.1
Arm predicted mass (left)	0.2	1.0	3.0	1.2	0.6	-1.7	-0.2	-0.2	1.0