Hub : Genes

TMC8

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.1370 0.0460 3.3e-03 0.019 NA 0.015 NA 0.012 1.0e-02 NA 1.8e-02 NA 3.4e-02
2 GTEx Skin Sun Exposed Lower leg 0.1360 0.0490 7.8e-03 0.003 NA -0.003 NA 0.001 1.6e-01 NA 8.0e-01 NA 2.4e-01
3 YFS Blood 0.3156 0.0299 0.0e+00 0.227 0.201 0.240 0.238 0.230 7.2e-73 8.0e-64 1.7e-77 1.4e-76 8.6e-74
4 TCGA Breast Invasive Carcinoma 0.0525 0.0197 9.3e-05 0.005 0.032 0.033 NA 0.024 3.1e-02 3.2e-07 1.9e-07 NA 7.8e-06
5 TCGA Brain Lower Grade Glioma 0.1061 0.0366 7.4e-06 0.068 0.055 0.065 NA 0.074 3.9e-08 7.2e-07 7.8e-08 NA 9.4e-09
6 TCGA Stomach Adenocarcinoma 0.1180 0.0540 3.8e-03 -0.003 0.019 0.004 NA -0.004 7.6e-01 1.4e-02 1.6e-01 NA 8.9e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 1.2 1.8 5.5 -0.3 -1.0 0.8 0.0 2.3 -2.0
Bipolar Disorder or Schizophrenia 0.4 1.0 2.8 -0.8 -1.1 0.5 0.0 1.7 -1.2
Depressed Affect (Nagel 2018) 0.4 0.9 3.2 -0.5 -1.8 1.2 0.1 -0.6 -0.5
Depression (Nagel 2018) 0.2 0.2 0.7 -0.2 -0.8 -0.4 0.6 0.3 0.3
Intelligence (Savage-Jansen 2018) 0.3 1.1 3.0 1.2 -0.2 -0.3 0.7 1.7 1.2
Neuroticism (Nagel 2018) 0.2 0.6 1.7 0.4 -1.3 0.7 0.5 0.0 -0.9
Schizophrenia (2018) 0.1 0.1 0.3 -0.6 -0.6 -0.0 0.0 0.2 0.0
Schizophrenia vs Biploar Disorder 0.2 0.3 1.6 0.5 -0.1 -1.3 0.0 0.0 0.3
Worry (Nagel 2018) 0.2 0.5 1.1 0.5 -1.0 0.8 0.3 0.7 -0.5
Alzheimer’s Disease (in mother) 0.9 1.1 2.5 -1.3 -1.6 0.4 -0.1 -0.1 1.5
Alzheimer’s Disease (in father) 2.8 3.0 5.3 -2.3 -0.8 1.8 -1.6 -1.8 -1.7
Alzheimer’s Disease (including proxy) 2.0 2.9 5.8 -2.4 -2.1 1.7 -1.4 -1.4 0.2
Crohns Disease (2017) 0.2 0.5 1.4 -1.2 -0.4 0.0 -0.8 -0.6 0.8
Irritable Bowel Disease (IBD) 0.4 0.9 1.5 -1.1 -1.2 0.9 -0.9 -0.9 0.4
Ulcerative Colitis (UC) 0.6 1.1 3.2 -0.5 -1.8 1.3 -0.6 -1.0 -0.1
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.4 0.7 1.2 -1.0 1.0 -0.2 -0.9 0.0 -1.1
Verbal and Numeric Reasoning (VNR) 0.3 0.6 1.0 0.9 -1.0 0.6 0.8 0.9 -0.4
Breast Cancer 1.4 3.3 9.9 1.8 1.3 0.1 2.1 0.8 3.1
Ovarian Cancer 1.3 1.7 4.6 0.8 0.8 -2.1 0.7 0.7 1.8
Prostate Cancer 0.5 0.8 3.7 0.6 -0.1 0.4 0.4 1.9 0.4
Age at First Birth 0.1 0.2 0.6 -0.2 0.4 -0.8 -0.1 -0.0 0.3
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.6 0.8 1.7 -0.4 -1.3 1.3 0.0 0.0 -1.3
Coronary Artery Disease (CAD) 0.6 0.7 2.5 -1.6 -0.1 1.2 0.0 0.0 0.2
Crohns Disease (2012) 0.3 0.6 2.1 -0.6 -0.9 0.3 0.0 0.0 -1.5
Mean Putamen Volume 1.1 1.3 3.3 -0.5 -1.8 0.8 -1.0 0.0 -1.5
Fasting Glucose 0.4 0.4 2.0 -0.4 -0.4 0.1 -0.5 -1.4 -0.1
HbA1C 2.5 2.7 8.2 1.4 1.2 -0.2 1.5 2.9 -1.6
HDL Cholesterol 0.2 0.4 1.9 -0.2 0.5 -0.0 0.0 0.3 -1.4
LDL Cholesterol 0.8 1.2 3.1 0.1 -1.0 1.5 0.0 1.1 -1.8
Lupus 0.2 0.4 0.8 0.3 0.7 0.2 0.8 -0.9 -0.1
Neuroticism (2016) 0.4 0.5 1.1 1.1 0.3 -0.5 1.0 -0.7 0.5
Primary Biliary Cirrhosis 0.5 0.7 2.3 0.4 -0.5 1.1 -0.7 0.0 -1.5
Rheumatoid Arthritis 0.2 0.3 1.0 -1.0 0.6 -0.3 0.0 0.0 0.8
Schizophrenia (2014) 0.3 0.6 2.8 -0.3 -0.6 -0.6 0.0 1.7 -0.2
Triglycerides 0.2 0.3 1.5 -0.4 -0.4 0.2 0.0 -1.2 -0.1
Type 2 Diabetes (T2D) (2012) 0.6 0.6 2.2 -0.1 -0.8 1.5 0.0 0.0 -1.0
Ulcerative Colitis 0.3 0.4 1.3 1.1 -1.0 0.4 0.0 0.0 -0.1
Blood Eosinophil Count 0.3 2.5 7.6 -2.5 -0.4 0.0 -0.8 -2.8 -0.2
Blood Platelet Count 0.6 7.1 18.3 0.0 3.0 -1.3 1.6 -4.3 3.4
Blood Red Count 3.9 37.8 141.6 4.5 -3.4 1.1 2.2 11.9 -6.9
Blood White Count 0.4 2.7 8.2 -0.9 -0.3 1.1 -1.4 -2.9 -1.9
Heel T-Score 0.7 5.3 11.6 -0.3 1.4 -1.1 -3.3 -2.5 -3.4
BMI 0.5 2.6 7.8 1.5 2.2 -2.8 0.4 -0.7 -0.0
Height 0.3 4.8 7.0 -2.6 -2.5 2.6 -2.6 -0.1 1.6
Waist Hip Ratio (WHR) 0.2 0.7 1.7 0.7 0.8 -0.7 0.2 1.3 0.9
Systolic Blood Pressure 0.2 0.9 3.1 1.8 0.4 -1.2 0.6 0.5 0.3
Smoking Status 0.3 0.6 1.0 -0.1 0.9 -1.0 0.2 -0.9 1.0
Allergy or Eczema 0.1 0.2 0.7 -0.2 -0.4 0.3 0.8 -0.5 -0.2
Cardiovascular Disease 0.4 1.4 3.0 1.7 0.9 -1.6 0.8 0.5 1.0
Hypothyroidism (self reported) 0.3 0.8 2.3 -0.3 -0.4 -1.0 0.6 1.5 0.9
Respiratory disease 0.3 0.8 2.3 -0.6 0.7 -1.5 0.7 -0.7 0.7
Type 2 Diabetes (T2D) (2018) 1.2 2.2 5.5 1.2 1.9 -2.3 1.3 -0.7 0.5
Lung FEV1/FVC ratio 0.1 0.6 1.6 0.2 -0.6 1.3 -0.8 -0.2 -0.9
Lung FVC 0.1 0.3 1.2 0.3 -0.3 1.1 -0.4 0.1 0.6
Neuroticism 0.1 0.1 0.5 0.7 -0.0 -0.1 0.4 -0.5 -0.1
Chronotype (morning person) 0.8 1.8 5.2 -0.6 0.9 0.6 -1.7 -1.1 -2.3
Hair Pigment 0.0 0.8 1.7 0.9 0.6 -0.3 -0.1 1.3 -1.2
Tanning 0.1 1.0 4.0 -0.1 -0.9 2.0 -1.0 0.3 -0.5
Hand grip strength (left) 0.4 0.9 1.8 1.3 -0.3 0.8 0.1 1.4 1.2
Number of treatments/medications taken 1.2 2.2 7.6 0.6 1.4 -2.8 1.1 -0.3 1.4
Average weekly spirits intake 1.1 1.4 4.0 1.6 2.0 -0.7 0.9 0.3 0.3
Sensitivity / hurt feelings 0.5 0.8 3.7 0.8 -0.1 -0.6 -0.3 0.0 -1.9
Frequency of depressed mood in last 2 weeks 1.0 1.4 4.0 1.3 1.1 -2.0 0.3 -0.2 1.1
Hearing difficulty/problems: Yes 0.5 0.7 1.7 1.2 0.3 -0.7 0.6 0.4 1.3
Relative age of first facial hair 0.3 0.6 1.6 1.0 -0.4 -0.4 0.5 0.7 -1.3
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 4.4 0.0 0.3 0.0 2.1 0.2 1.2
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.9 0.4 0.4 -0.5 -1.4 -0.5 -0.7
Ever had hysterectomy (womb removed) 0.1 0.1 0.3 -0.5 0.2 0.3 -0.1 0.1 0.5
Systolic blood pressure, automated reading 0.5 1.4 4.1 1.5 1.0 -2.0 0.3 1.0 0.1
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 3.3 -0.1 1.2 -0.4 1.8 -0.1 1.5
Angina 0.6 0.8 2.4 -0.1 -0.3 -0.5 1.4 -0.6 1.5
Medication for hormone replacement therapy 0.2 0.2 0.6 0.8 0.5 -0.6 0.2 -0.2 0.4
Vitamin and mineral supplements 0.3 0.5 1.0 0.3 0.6 -0.7 0.1 1.0 0.9
Supplements: Zinc 0.2 0.2 0.7 -0.4 -0.1 0.2 0.4 -0.8 -0.2
Medication: Co-codamol 0.5 0.6 1.5 -1.2 -0.2 0.3 -1.0 0.8 0.4
Medication: Metformin 1.2 1.7 5.9 1.0 1.7 -2.4 0.2 -0.7 0.1
Diabetes (father) 0.3 0.4 0.8 -0.3 0.3 -0.2 -0.9 -0.9 -0.8
Diabetes (mother) 0.7 0.8 1.5 -0.1 0.6 -0.9 -1.1 -1.2 1.2
Severe depression (siblings) 0.6 0.6 1.1 -0.8 -1.1 0.3 -1.1 0.4 -0.7
Pack years adult smoking proportion 1.6 2.4 5.0 -0.3 1.7 -2.2 1.2 -0.7 2.1
Impedance of leg (right) 0.7 3.5 10.9 -3.3 -0.8 2.2 -2.0 -0.8 -0.5
Leg fat-free mass (left) 0.1 0.4 1.0 0.9 -0.2 -0.5 0.2 0.1 1.0
Trunk fat percentage 0.2 0.7 2.1 0.1 0.7 -1.4 0.8 0.9 -0.2
Hand grip strength (right) 0.3 0.8 1.8 1.3 0.6 0.1 -0.1 1.1 1.1
Townsend deprivation index at recruitment 2.9 4.0 6.6 2.4 2.4 -2.6 1.9 1.2 1.1
Current tobacco smoking 0.6 1.1 4.5 0.3 0.4 -0.3 1.1 -0.6 2.1
Average weekly fortified wine intake 0.2 0.2 0.5 0.1 -0.4 0.0 0.7 0.1 0.6
Maternal smoking around birth 1.4 2.0 4.0 -0.6 -0.0 0.4 -1.8 -2.0 -2.0
Fed-up feelings 0.2 0.4 1.4 -0.2 -0.2 0.5 -0.5 -1.2 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.4 0.2 -0.6 -0.4 0.4 -0.2 -0.0
Relative age voice broke 0.3 0.5 0.9 1.0 0.4 -0.9 0.4 0.2 -0.8
Taking other prescription medications 0.9 1.4 5.5 0.2 0.7 -2.3 0.5 -0.3 1.4
Age when periods started (menarche) 0.2 0.5 1.1 1.1 -0.2 -0.2 0.7 0.6 0.9
Bilateral oophorectomy (both ovaries removed) 1.3 1.5 5.2 -2.3 -0.3 0.8 -1.4 -1.1 0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 2.5 -0.5 1.1 -1.6 -0.8 -0.7 -0.5
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 1.2 0.3 0.1 0.2 1.1 -0.1 0.5
Qualifications: CSEs or equivalent 1.1 1.5 3.5 1.9 1.8 -1.0 0.7 0.8 -0.4
Serious illness, injury or assault to yourself 0.8 1.0 2.2 -1.0 -0.5 0.8 -0.8 -1.5 1.1
High blood pressure 0.5 1.5 4.1 1.3 0.4 -2.0 1.3 1.0 0.5
Hayfever, allergic rhinitis or eczema 0.2 0.4 0.7 -0.5 -0.4 0.8 0.4 -0.8 -0.8
Multivitamins +/- minerals 0.4 0.5 2.0 0.6 0.1 0.4 0.6 -0.1 -1.4
Stomach or abdominal pain in last month 0.4 0.5 1.1 -0.5 -0.9 1.0 -0.7 -0.6 0.3
Supplements: Glucosamine 0.3 0.4 0.9 0.9 -0.8 0.6 -0.4 0.3 0.2
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 5.1 0.6 0.1 0.4 0.1 0.4 -2.3
Medication: Atenolol 0.3 0.4 1.8 -1.4 -0.1 -0.5 -0.2 -0.1 0.5
Medication: Levothyroxine sodium 0.4 0.7 2.3 -0.4 0.1 -1.2 -0.0 1.5 -0.4
Sitting height 0.2 1.5 3.4 -1.9 -0.2 1.3 -1.7 0.4 1.0
Chronic bronchitis/emphysema (father) 0.4 0.5 0.7 0.8 0.8 -0.7 0.6 0.3 0.8
High blood pressure (mother) 0.3 0.4 0.6 0.6 -0.2 -0.6 0.8 0.7 -0.7
Body mass index (BMI) 0.7 3.1 8.9 2.1 1.9 -3.0 1.2 0.1 0.1
Impedance of leg (left) 0.5 2.5 7.3 -2.7 -0.6 1.5 -2.0 -0.1 -1.2
Leg predicted mass (left) 0.1 0.4 1.1 1.0 -0.2 -0.6 0.3 0.1 1.0
Trunk fat mass 0.2 1.0 2.9 0.7 0.8 -1.7 0.9 1.0 0.3
Waist circumference 0.9 3.1 8.5 1.9 1.8 -2.9 1.3 0.7 1.1
Number of incorrect matches in round 0.5 0.9 3.7 -0.8 -1.9 0.2 -0.9 0.3 -0.0
Past tobacco smoking 0.3 0.6 1.6 0.1 -1.3 1.2 -0.4 0.7 0.1
Alcohol usually taken with meals 0.7 1.2 2.9 1.7 0.2 0.8 1.4 1.2 0.2
Nervous feelings 0.1 0.3 0.9 1.0 -0.6 0.3 -0.1 0.4 0.1
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 2.0 1.4 0.4 -0.2 0.7 0.2 0.4
Hearing difficulty/problems with background noise 0.1 0.2 0.7 -0.2 -0.4 0.0 -0.2 -0.8 0.5
Hair/balding pattern: Pattern 2 0.6 0.8 2.3 -0.1 1.5 -0.3 0.2 -1.0 1.1
Had menopause 0.4 0.5 1.1 0.7 0.2 -0.4 0.5 0.9 -1.0
Had other major operations 0.3 0.4 1.5 0.4 0.4 -0.1 1.2 -0.2 -0.6
Forced vital capacity (FVC) 0.4 1.7 5.2 -1.4 -0.7 2.3 -1.1 -0.1 1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.9 3.3 1.2 1.8 -1.8 1.4 1.0 -0.4
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 1.0 -1.0 -0.4 0.2 0.3 0.3 0.5
Qualifications: None of the above 0.4 0.8 2.2 -1.4 -1.5 -0.1 -0.5 0.0 0.4
Financial difficulties in last 2 years 0.6 0.8 1.4 -0.9 -0.9 0.9 1.2 0.9 0.2
Mouth/teeth dental problems 1.1 1.6 6.5 -0.2 -1.1 0.6 -1.3 -2.5 -0.3
Heart attack 0.4 0.5 1.3 -1.1 0.3 -0.4 1.0 0.5 0.1
Allergy 0.1 0.3 0.6 0.5 0.8 0.1 -0.1 0.7 -0.4
Pain all over the body in last month 0.7 0.7 3.8 -0.2 -0.3 -0.5 -0.2 1.9 -0.4
Diabetes (self-reported) 1.0 1.5 4.1 1.6 1.2 -2.0 0.6 -0.4 0.8
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 1.3 1.1 1.1 -1.0 0.8 -0.3 -0.3
Medication: Ramipril 0.1 0.2 0.8 -0.9 0.0 -0.0 0.2 -0.4 -0.1
Medication: Simvastatin 0.3 0.5 0.9 -0.3 0.5 -0.9 0.9 0.1 0.8
Fluid intelligence score 1.2 2.5 5.5 -1.2 -2.4 2.1 -1.0 -1.0 -1.3
Illnesses of siblings 0.2 0.3 0.6 0.0 0.5 -0.1 0.7 -0.8 0.6
Neuroticism score 0.2 0.4 1.4 -0.0 -0.1 0.3 -0.2 -1.0 -1.2
Weight 0.2 1.1 3.3 1.2 1.1 -1.8 0.5 0.3 0.6
Impedance of arm (right) 0.4 1.9 5.2 -2.3 -1.2 2.1 -0.4 0.0 0.5
Arm fat percentage (right) 0.5 2.0 6.1 1.4 1.2 -2.5 1.4 0.2 0.4
Trunk fat-free mass 0.1 0.7 1.8 1.1 0.1 -0.8 -0.5 0.1 1.3
Hip circumference 0.4 1.8 5.5 1.3 1.4 -2.3 0.8 -0.2 1.2
Time employed in main current job 0.6 0.7 3.2 0.4 0.1 0.8 -0.1 1.8 0.1
Alcohol intake versus 10 years previously 0.3 0.5 1.9 0.0 0.0 0.9 1.4 -0.4 0.3
Father’s age at death 0.3 0.5 2.3 -0.1 -1.5 0.4 0.1 -0.2 -0.4
Worrier / anxious feelings 0.2 0.4 1.0 -0.0 -0.4 0.9 1.0 -0.1 0.5
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 1.8 0.7 1.3 -0.6 0.4 -0.2 -0.0
Falls in the last year 0.6 0.8 2.2 -0.3 0.4 -1.0 -0.3 -1.2 1.5
Hair/balding pattern: Pattern 3 0.5 0.7 2.0 0.3 0.7 -1.4 -0.5 -1.2 -0.4
Number of live births 1.6 2.3 6.9 -0.8 -1.2 0.4 -2.6 -2.1 -0.5
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 4.8 -0.9 -0.7 2.2 -1.1 0.1 0.8
Pulse rate 1.1 1.8 5.1 1.3 2.2 -1.5 1.1 -0.0 -0.9
Happiness 0.7 0.9 2.2 0.3 -1.3 0.5 -0.3 1.5 -1.0
Noisy workplace 4.7 5.7 13.8 2.4 1.3 -1.5 3.7 2.5 2.2
Qualifications: A levels/AS levels or equivalent 0.3 0.6 1.1 0.3 1.0 -1.0 0.5 -0.5 -0.9
Serious illness, injury or assault of a close relative in last 2 years 2.8 3.2 5.2 -1.4 -2.3 1.8 -1.6 -1.7 -1.9
Mouth/teeth dental problems: Dentures 1.1 1.9 6.0 0.7 -0.3 -1.5 1.6 2.4 0.2
Asthma 0.3 0.7 1.6 -0.3 0.4 -1.1 0.6 -1.2 0.7
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.4 -0.5 0.3 0.3 -0.0 0.0 0.6
Medication: Cholesterol lowering 0.9 1.4 2.7 -0.7 1.5 -1.6 0.8 -0.9 1.2
Depression (self-reported) 0.8 1.0 2.7 0.1 1.0 -1.2 0.9 0.3 1.7
Medication: Lansoprazole 0.6 0.7 1.5 -0.8 -0.1 -0.9 0.9 1.2 0.4
Prospective memory result 2.0 2.4 3.3 1.8 1.4 -1.7 1.6 1.7 0.9
Lung cancer (father) 1.0 1.2 2.1 1.1 1.4 -0.8 1.4 0.5 1.0
Illnesses of mother 0.6 0.7 2.7 0.3 0.9 -0.6 -0.7 -1.6 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 2.7 -0.1 -0.7 1.6 -0.3 0.7 0.6
Pulse wave Arterial Stiffness index 0.6 0.7 2.9 0.7 0.4 -0.3 0.3 1.7 0.7
Impedance of arm (left) 0.8 3.7 9.7 -2.9 -1.7 3.1 -0.8 0.5 -0.5
Arm fat mass (right) 0.3 1.3 4.3 1.3 1.0 -2.1 0.9 0.3 0.2
Trunk predicted mass 0.1 0.7 1.8 1.2 0.0 -0.8 -0.5 0.1 1.4
Standing height 0.2 2.4 5.4 -1.7 -1.6 2.3 -1.5 0.6 1.0
Length of working week for main job 0.5 0.6 1.6 1.2 1.3 -0.2 0.1 -0.5 -0.2
Exposure to tobacco smoke at home 0.4 0.5 1.3 -0.3 0.5 -1.1 -0.3 -1.1 -0.3
Breastfed as a baby 0.3 0.3 0.6 0.8 0.2 -0.7 -0.2 -0.6 0.7
Tense / ‘highly strung’ 0.0 0.1 0.2 0.4 0.3 -0.2 0.0 0.3 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 2.0 0.3 1.4 -0.8 0.2 -0.0 -0.1
Hair/balding pattern: Pattern 4 0.8 2.1 5.4 2.3 -0.2 0.4 1.7 1.3 1.4
Birth weight of first child 0.4 0.7 2.6 -1.6 0.5 0.5 -0.6 -0.8 -0.6
Peak expiratory flow (PEF) 0.1 0.3 0.6 -0.1 0.3 0.5 -0.8 -0.4 0.5
Pulse wave reflection index 0.4 0.4 1.5 0.8 -0.0 -0.0 0.6 0.2 1.2
Ever highly irritable/argumentative for 2 days 0.9 1.1 2.5 -1.0 -0.4 0.3 -1.6 -1.4 -0.9
Loud music exposure frequency 1.0 1.1 2.7 -0.1 -0.7 1.5 -1.0 -0.2 -1.6
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 2.0 -0.5 0.0 0.6 -1.0 -0.3 -1.4
Mouth/teeth dental problems: Bleeding gums 0.6 0.7 2.0 -0.7 -0.0 0.9 0.9 1.4 -0.3
Blood clot in the leg (DVT) 0.7 0.9 2.7 -0.0 -1.5 -0.1 0.4 0.6 1.6
Medication: Paracetamol 0.4 0.7 1.3 -0.4 -0.7 -1.1 0.9 0.3 1.1
Headache pain in last month 0.8 1.3 2.7 -1.6 -1.6 0.1 0.3 -0.3 1.6
Medication for cholesterol, blood pressure or diabetes 1.0 1.6 4.5 1.5 -0.6 1.3 0.2 2.1 -1.0
Glaucoma (self-reported) 0.7 0.8 3.1 0.3 1.1 0.3 -0.0 1.8 -0.5
Gout (self-reported) 1.5 2.1 6.7 0.5 0.8 -1.0 1.9 0.7 2.6
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 4.4 0.5 -0.4 -1.1 0.8 2.1 0.6
Medication: Amlodipine 0.1 0.1 0.3 0.1 -0.6 0.3 -0.5 -0.4 -0.0
Medication: Ventolin 100micrograms inhaler 2.5 3.2 8.8 1.5 3.0 -2.6 0.7 0.1 1.0
Birth weight 2.0 4.4 7.7 -2.8 -2.6 1.8 -2.2 -1.4 -1.4
Chronic bronchitis/emphysema (mother) 0.8 0.9 2.5 -0.9 -1.6 1.2 -0.5 0.1 -0.5
High blood pressure (siblings) 0.4 0.6 2.0 0.2 -0.1 0.3 -0.3 1.4 -1.1
Forced vital capacity (FVC), Best measure 0.3 1.2 3.9 -0.7 -1.1 2.0 -0.3 0.6 1.1
Body fat percentage 0.3 1.0 3.6 0.6 0.9 -1.9 0.8 0.7 -0.3
Leg fat percentage (right) 0.5 2.0 6.9 0.8 1.8 -2.6 0.9 0.4 0.1
Arm fat-free mass (right) 0.1 0.4 1.3 1.1 0.2 -0.8 -0.5 0.2 0.5
Exposure to tobacco smoke outside home 0.4 0.5 2.3 0.2 -0.5 0.5 1.5 -0.3 -0.4
Comparative body size at age 10 0.7 1.8 5.6 1.3 -0.4 -0.0 2.4 1.1 1.4
Number of full brothers 1.1 1.4 3.6 0.2 -1.9 1.3 -1.4 -0.6 -0.9
Worry too long after embarrassment 0.4 0.6 1.8 -0.2 -0.6 0.7 -0.4 -1.0 -1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.7 2.2 -1.1 0.6 -0.4 0.4 -1.5 0.4
Wheeze or whistling in the chest in last year 0.3 0.5 1.1 -0.3 0.6 -0.9 0.7 -1.0 0.2
Number of children fathered 0.9 1.0 5.8 -2.4 -0.1 0.1 -0.1 0.1 0.0
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 3.1 -0.2 -0.1 0.3 -1.1 -0.2 -1.8
Age at first live birth 0.2 0.4 1.4 -0.1 -0.7 1.2 0.1 0.5 -0.0
Pulse wave peak to peak time 0.5 0.6 1.9 -0.8 -0.5 0.5 -0.4 -1.4 -0.6
Health satisfaction 0.7 0.9 1.6 0.6 0.3 -1.1 1.2 1.3 0.7
Shortness of breath walking on level ground 0.6 0.7 1.9 0.4 0.5 -1.4 1.0 0.8 0.4
Qualifications: College or University degree 0.3 0.9 2.8 0.7 0.3 -0.5 1.7 0.1 1.2
Eye problems/disorders: None of the above 0.4 0.4 1.1 -0.2 -1.0 -0.3 -1.0 0.0 -0.5
Mouth/teeth dental problems: Loose teeth 0.7 0.8 2.2 0.4 1.5 -1.2 0.4 -0.5 0.7
Emphysema/chronic bronchitis 0.5 0.5 1.3 -0.9 0.4 -1.2 -0.8 -0.1 0.6
Medication for pain relief, constipation, heartburn 1.0 1.6 3.6 -0.9 -0.4 1.5 -1.9 -1.1 -1.3
Neck or shoulder pain in last month 0.1 0.2 0.9 0.2 -0.4 -0.1 0.4 -0.0 -1.0
Medication: Blood pressure 1.0 1.7 5.9 -1.7 -0.6 -0.1 -0.8 -2.4 0.5
Angina (self-reported) 0.6 0.8 2.3 0.0 0.0 -0.6 1.4 -0.5 1.5
Migraine (self-reported) 0.5 0.6 1.7 -1.1 0.0 -1.3 -0.8 0.2 -0.3
Medication: Ibuprofen 0.1 0.1 0.3 -0.5 0.1 0.4 -0.0 -0.2 0.1
Medication: Allopurinol 0.6 0.8 2.6 0.4 0.4 0.3 0.9 0.8 1.6
Medication: Omeprazole 0.7 0.8 1.9 -0.9 -1.4 0.7 -1.0 -0.5 -0.5
Medication: Seretide 50 evohaler 0.3 0.3 0.9 0.9 0.5 0.1 0.4 -0.1 -0.8
Mean time to correctly identify matches 0.4 0.8 1.7 -1.3 0.9 -0.5 -1.2 0.2 -0.9
Heart disease (mother) 2.2 2.6 7.3 1.3 0.2 -0.7 2.2 2.7 1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.1 0.6 -0.5 -0.7 -0.4 0.9 -1.0
Whole body fat mass 0.2 0.9 3.4 0.8 0.8 -1.8 0.6 0.8 0.2
Leg fat mass (right) 0.3 1.2 4.8 0.8 1.2 -2.2 0.6 0.3 0.2
Arm predicted mass (right) 0.1 0.6 1.5 1.2 0.3 -1.1 -0.4 -0.0 0.8
Pulse rate, automated reading 1.0 3.1 9.6 1.7 0.4 -0.9 3.1 2.3 0.0
Alcohol intake frequency. 0.3 0.7 1.5 0.7 0.9 -1.2 1.1 0.4 -0.1
Comparative height size at age 10 0.3 1.7 3.3 -1.8 -1.4 1.3 -1.1 0.8 1.2
Number of full sisters 0.5 0.7 2.8 -0.9 -0.1 -0.6 -0.0 -1.7 0.0
Suffer from ‘nerves’ 0.8 1.2 2.3 1.5 1.2 -1.1 1.5 0.6 0.1
Overall health rating 0.3 0.6 1.8 -1.0 -0.5 -0.2 -0.3 -0.8 1.3
Chest pain or discomfort 0.0 0.1 0.2 -0.4 0.2 -0.2 0.0 -0.2 -0.3
Had major operations 1.5 1.8 4.5 -1.4 -2.1 0.7 0.4 1.6 -0.9
Age at last live birth 0.8 1.1 3.1 -0.4 -1.8 1.1 -1.2 -0.9 -0.1
Family relationship satisfaction 0.3 0.4 1.0 -0.7 -0.7 -0.1 -0.4 0.4 -1.0
Leg pain on walking 0.4 0.5 1.8 -0.2 0.1 -1.3 -0.1 0.6 0.8
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.0 1.0 0.9 0.3 -0.4 0.8 -0.9
Commuting to job workplace: Car/motor vehicle 1.1 1.2 2.6 -1.3 -0.2 1.0 -1.6 -1.4 -0.2
Illness, injury, bereavement, stress in last 2 years 1.1 1.4 3.0 1.7 1.2 -1.1 0.2 1.4 -0.8
Medication: Aspirin 2.5 3.3 9.5 1.3 1.5 -2.1 3.1 0.8 1.1
Supplements: Vitamin C 1.9 2.2 5.7 -1.0 -0.7 1.4 -2.4 -2.0 -0.2
Knee pain experienced in last month 0.6 0.9 1.8 1.3 0.1 -0.7 1.3 -0.5 -1.0
Hypertension (Self-reported) 0.5 1.3 2.9 1.0 0.5 -1.7 1.4 1.2 0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 3.0 0.2 -0.3 0.2 0.1 0.8 1.7
Illnesses of father: Heart disease 2.0 2.8 7.8 0.7 -1.8 1.6 1.5 2.8 -0.9
Illnesses of siblings: Diabetes 1.0 1.2 3.7 0.4 0.5 -1.9 -0.4 -1.3 1.1
Smoking status: Previous 0.6 0.9 2.4 0.4 1.5 -1.4 -0.0 -0.1 -0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 1.1 0.2 -1.1 0.4 0.1 -0.4 0.8
Whole body fat-free mass 0.1 0.6 1.4 1.1 0.0 -0.9 -0.2 0.2 1.2
Leg fat-free mass (right) 0.1 0.6 2.0 1.4 -0.2 -0.7 0.4 0.4 0.7
Arm fat percentage (left) 0.3 1.4 3.7 1.2 0.9 -1.9 1.4 0.5 0.0
Average weekly red wine intake 0.3 0.5 1.7 0.4 0.8 -1.3 -0.6 -0.2 0.3
Handedness (chirality/laterality): Left-handed 0.8 0.9 3.8 -0.5 0.2 0.8 0.6 1.9 0.7
Mood swings 0.5 0.9 4.1 1.2 -0.1 0.1 -0.1 -0.4 -2.0
Loneliness, isolation 0.3 0.5 1.7 0.6 -0.4 -0.2 1.3 0.1 0.7
Long-standing illness, disability or infirmity 1.2 1.8 4.8 0.9 1.2 -2.2 1.6 -0.2 1.1
Ever had bowel cancer screening 0.8 0.9 2.7 -1.6 -0.2 0.0 -1.6 0.1 0.2
Diabetes diagnosed by doctor 1.4 2.3 5.2 1.6 2.2 -2.3 0.6 -0.6 0.8
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 3.5 -1.0 -1.9 1.3 -0.4 1.1 -1.0
Friendships satisfaction 0.8 0.9 3.6 -0.6 -1.9 0.6 -0.5 0.5 -1.0
Qualifications: nursing, teaching 0.2 0.3 1.1 0.1 -0.7 0.4 1.1 0.5 -0.0
Commuting to job workplace: Walk 2.3 2.4 5.8 0.2 1.0 -2.1 2.4 -0.7 1.7
Eye problems/disorders: Cataract 0.6 0.6 3.5 0.2 0.2 0.5 1.9 0.2 0.2
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.8 -0.5 0.9 0.6 -0.2 0.6 -0.4
Medication for cholesterol 0.2 0.4 0.8 -0.3 -0.7 0.9 -0.1 -0.9 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.8 -0.3 -1.2 0.6 -0.6 1.3 0.1
Back pain experienced in last month 0.1 0.1 0.5 -0.2 0.1 -0.0 -0.7 -0.5 -0.3
Mineral and other dietary supplements 0.2 0.2 0.7 -0.4 0.9 -0.2 0.4 -0.1 -0.5
Breast cancer (self-reported) 0.6 0.7 2.1 0.6 -1.1 0.1 1.4 -0.6 -0.3
Asthma (self-reported) 0.3 0.5 1.3 -0.2 0.3 -1.1 0.4 -1.0 0.6
Osteoporosis (self-reported) 0.5 0.6 2.8 -0.0 0.2 -0.5 0.7 0.5 1.7
Osteoarthritis (self-reported) 0.5 0.6 2.4 0.4 -0.6 0.4 0.8 1.6 0.0
Medication: Aspirin 2.0 2.6 8.4 0.9 1.2 -1.8 2.9 0.4 1.1
Medication: Gliclazide 0.9 1.0 2.2 0.9 1.0 -1.5 -0.7 -1.0 0.8
Illnesses of father: None of the above (group 1) 0.9 1.1 3.7 -0.5 1.1 -0.1 -1.9 -1.1 0.6
Smoking status: Current 0.5 0.8 3.2 0.2 0.3 -0.3 1.0 -0.5 1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 1.6 -0.6 -0.1 0.5 -1.3 -0.6 0.3
Whole body water mass 0.1 0.6 1.5 1.1 0.1 -0.9 -0.2 0.1 1.2
Leg predicted mass (right) 0.1 0.6 2.0 1.4 -0.2 -0.8 0.4 0.4 0.7
Arm fat mass (left) 0.3 1.3 3.7 1.4 1.0 -1.9 1.0 0.6 0.1
Number of self-reported non-cancer illnesses 0.2 0.4 1.9 -0.2 -0.0 -1.4 0.3 0.7 0.1
Average weekly champagne plus white wine intake 1.1 1.4 4.0 -0.1 -1.2 2.0 -0.7 0.8 -1.5
Miserableness 0.4 0.6 1.7 0.5 0.1 -0.4 1.3 -1.3 0.2
Guilty feelings 0.7 1.1 3.1 0.5 1.3 -1.1 1.8 0.7 -0.3
Wears glasses or contact lenses 1.7 2.0 4.6 2.1 1.0 -1.1 1.1 0.5 1.9
Ever taken oral contraceptive pill 0.5 0.5 2.2 0.4 0.6 0.4 0.6 1.5 -0.2
Hearing aid user 0.4 0.4 1.5 -1.2 -0.4 0.2 -0.8 0.3 -0.1
Mother’s age at death 0.6 0.7 1.8 0.0 1.3 -1.0 -0.8 0.1 1.0
Financial situation satisfaction 1.0 1.3 4.6 1.4 -0.2 0.7 0.6 2.1 -0.4
Tinnitus: Yes, now most or all of the time 0.9 1.1 1.6 -0.9 -1.3 1.2 -0.0 0.9 -1.3
Commuting to job workplace: Public transport 1.0 1.2 2.9 1.4 1.7 -1.1 0.7 0.1 0.8
Eye problems/disorders: Glaucoma 0.8 0.9 4.0 0.5 0.5 0.7 0.7 2.0 -0.4
Medication: Blood pressure 0.8 1.6 2.9 1.2 1.3 -1.5 1.1 1.7 -0.2
Pain type(s) experienced in last month: Hip pain 1.1 1.3 2.7 1.6 1.2 -1.6 -0.3 1.0 0.7
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.7 0.6 -0.9 -0.3 -0.3 -0.2 -0.0
High cholesterol (Self-reported) 0.3 0.5 1.5 -1.2 -0.8 0.2 -0.4 -0.7 0.2
Medication: Bendroflumethiazide 1.1 1.6 3.5 1.2 -0.4 -1.4 1.3 1.9 -0.9
Medication: Paracetamol 0.3 0.5 1.2 -1.0 -1.1 -0.5 0.3 -0.2 0.8
Medication: Lisinopril 0.1 0.2 0.6 -0.5 -0.5 0.1 -0.0 -0.7 0.1
Medication: Atorvastatin 0.8 1.0 2.8 -0.4 1.1 -1.1 -0.7 -1.7 -0.1
Illnesses of father: High blood pressure 0.4 0.5 0.9 0.7 0.5 -0.7 -0.4 -0.9 -0.8
Alcohol drinker status: Never 0.7 0.9 2.0 -1.0 0.4 -1.2 -0.6 -0.6 -1.4
Ever smoked 0.7 1.3 3.3 -0.3 1.4 -1.3 0.2 -1.8 0.9
Basal metabolic rate 0.1 0.5 0.9 1.0 0.1 -0.9 -0.2 0.2 1.0
Leg fat percentage (left) 0.8 2.9 10.5 1.3 1.9 -3.2 0.9 0.7 -0.4
Arm fat-free mass (left) 0.1 0.7 1.8 1.2 0.3 -1.4 -0.5 0.0 0.9
Number of operations (self-reported) 0.2 0.3 0.6 -0.8 0.7 -0.3 0.3 0.1 -0.7
Average weekly beer plus cider intake 0.2 0.2 0.6 -0.1 0.7 0.1 -0.4 0.6 -0.5
Irritability 0.5 0.8 3.7 -0.5 -0.0 0.5 -0.3 -0.5 -1.9
Risk taking 0.5 0.7 1.6 -1.0 0.1 1.2 0.3 -1.3 -0.3
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.6 -1.3 -1.0 -0.0 -0.9 -0.5 -0.2
Fractured/broken bones in last 5 years 0.3 0.4 1.6 -0.6 -0.4 1.3 0.0 -0.2 0.1
Age started oral contraceptive pill 0.3 0.4 1.6 0.3 -0.2 0.1 -1.2 0.7 -0.3
Diastolic blood pressure, automated reading 0.6 1.8 4.1 1.3 0.7 -1.9 0.9 2.0 -0.6
Ever depressed for a whole week 0.3 0.4 1.1 0.3 0.4 -0.6 1.0 0.7 -0.3
Unable to work because of sickness or disability 2.3 3.0 7.2 1.5 2.7 -2.4 1.4 -0.0 0.9
Commuting to job workplace: Cycle 1.3 1.6 2.7 -1.2 -1.0 1.5 -1.3 -0.6 -1.6
Myopia 0.4 0.6 1.8 1.3 -0.8 0.4 0.2 0.9 0.5
Vascular/heart problems diagnosed by doctor 0.7 1.8 4.0 -1.2 -0.3 2.0 -1.8 -1.2 -0.7
Cholesterol lowering medication 0.2 0.4 1.0 -0.6 -1.0 -0.1 -0.1 -0.9 -0.0
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.9 -0.6 -1.4 0.6 -0.5 -0.6 -0.3
Pain experienced in last month 1.0 1.6 3.2 1.8 1.8 -0.3 0.9 1.4 0.7
Supplements: Calcium 0.4 0.5 1.3 0.4 0.7 -0.6 0.2 -1.2 0.7
Basal cell carcinoma (self-reported) 1.5 1.8 3.4 -1.9 -1.3 1.4 -1.1 0.4 -1.4
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.3 -1.1 -0.0 -0.4 0.8 0.4 0.2
Deep venous thrombosis (DVT) (self-reported) 0.7 0.8 2.8 -0.2 -1.4 0.0 0.2 0.6 1.7
Heart disease (siblings) 0.2 0.2 0.4 0.7 -0.5 0.3 -0.1 0.5 -0.5
Alcohol drinker status: Previous 0.3 0.3 1.0 0.2 1.0 -0.3 -0.5 -0.4 -0.5
Pack years of smoking 1.6 2.3 6.1 -0.3 1.7 -2.5 1.1 -0.3 1.8
Impedance of whole body 0.7 3.4 10.5 -3.2 -1.3 2.5 -1.3 0.1 -0.7
Leg fat mass (left) 0.4 1.7 6.5 1.2 1.3 -2.6 0.6 0.6 -0.1
Arm predicted mass (left) 0.2 1.0 3.0 1.2 0.6 -1.7 -0.2 -0.2 1.0