[Hub]/) : Traits : Blood Red Count :

chr17:78,826,134-81,051,007

Best TWAS P=1.89e-12 · Best GWAS P=3.86e-22 conditioned to 3.32e-13

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CCDC137 0.12 0.09 enet 14 0.10 9.6e-13 6.1 6.5 9.7e-11 0.34 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex MRPL12 0.04 0.02 lasso 4 0.03 3.8e-04 3.5 5.5 3.5e-08 0.21 0.32 0.02 FALSE
3 GTEx Adipose Subcutaneous CCDC137 0.14 0.06 lasso 2 0.07 1.3e-06 6.5 -5.8 7.1e-09 -0.25 0.85 0.01 FALSE
4 GTEx Adipose Subcutaneous ARL16 0.46 0.49 lasso 5 0.51 3.1e-48 5.0 -5.5 3.6e-08 -0.28 1.00 0.00 FALSE
5 GTEx Artery Aorta STRA13 0.20 0.14 enet 16 0.11 7.9e-07 -2.4 5.6 2.3e-08 0.16 0.84 0.01 FALSE
6 GTEx Artery Aorta ARL16 0.51 0.46 enet 13 0.46 7.0e-28 5.0 -5.4 5.5e-08 -0.28 1.00 0.00 FALSE
7 GTEx Artery Coronary ARL16 0.61 0.38 lasso 7 0.37 1.4e-13 5.0 -5.3 1.0e-07 -0.27 1.00 0.00 FALSE
8 GTEx Artery Tibial LRRC45 0.09 0.07 lasso 4 0.04 2.0e-04 -4.7 6.2 5.0e-10 0.05 0.84 0.01 FALSE
9 GTEx Artery Tibial ARL16 0.40 0.40 lasso 3 0.39 1.2e-32 5.0 -5.2 2.0e-07 -0.26 1.00 0.00 FALSE
10 GTEx Brain Caudate basal ganglia ARL16 0.43 0.27 enet 6 0.34 1.1e-10 5.0 -5.7 1.2e-08 -0.28 0.97 0.00 FALSE
11 GTEx Brain Cerebellar Hemisphere ARL16 0.33 0.25 lasso 5 0.25 4.2e-07 4.8 -5.4 5.2e-08 -0.31 0.90 0.03 FALSE
12 GTEx Brain Cerebellum NARF 0.20 0.07 enet 19 0.03 4.2e-02 3.4 -5.3 9.5e-08 0.03 0.12 0.05 FALSE
13 GTEx Brain Cerebellum ARL16 0.43 0.20 lasso 8 0.20 1.2e-06 5.0 -6.0 1.5e-09 -0.31 0.88 0.04 FALSE
14 GTEx Brain Hippocampus ARL16 0.30 0.31 lasso 3 0.31 4.4e-08 5.0 -5.5 4.6e-08 -0.28 0.70 0.07 FALSE
15 GTEx Brain Nucleus accumbens basal ganglia ARL16 0.25 0.27 lasso 3 0.24 5.8e-07 5.0 -5.3 1.3e-07 -0.27 0.50 0.12 FALSE
16 GTEx Brain Putamen basal ganglia ARL16 0.23 0.18 lasso 4 0.16 1.4e-04 5.0 -6.1 9.1e-10 -0.28 0.12 0.06 FALSE
17 GTEx Breast Mammary Tissue (Female) NPLOC4 0.04 -0.01 lasso 2 -0.01 7.7e-01 5.2 -5.2 2.4e-07 -0.31 0.03 0.06 FALSE
18 GTEx Cells Transformed fibroblasts HGS 0.09 0.11 lasso 3 0.10 5.9e-08 6.3 -6.0 2.0e-09 -0.30 0.98 0.00 FALSE
19 GTEx Colon Transverse ARL16 0.58 0.56 enet 15 0.59 3.9e-34 5.0 -6.1 1.4e-09 -0.29 1.00 0.00 FALSE
20 GTEx Esophagus Gastroesophageal Junction ARL16 0.69 0.53 lasso 6 0.53 2.8e-22 5.0 -5.4 8.2e-08 -0.28 1.00 0.00 FALSE
21 GTEx Esophagus Mucosa ARL16 0.58 0.54 enet 35 0.63 5.3e-53 5.0 -5.3 9.8e-08 -0.27 1.00 0.00 FALSE
22 GTEx Heart Atrial Appendage LRRC45 0.19 0.06 enet 9 0.12 6.7e-06 -5.8 5.5 3.4e-08 0.03 0.75 0.01 FALSE
23 GTEx Lung NPLOC4 0.11 0.07 lasso 1 0.04 3.2e-04 5.3 -5.3 1.1e-07 -0.31 0.44 0.03 FALSE
24 GTEx Nerve Tibial NPLOC4 0.13 0.03 lasso 2 0.03 3.0e-03 5.3 -5.7 1.3e-08 -0.26 0.17 0.03 FALSE
25 GTEx Nerve Tibial ARL16 0.60 0.43 enet 18 0.50 5.8e-40 5.0 -5.6 2.1e-08 -0.27 1.00 0.00 FALSE
26 GTEx Ovary RAB40B 0.31 -0.01 enet 28 0.04 4.1e-02 2.4 -5.7 1.0e-08 -0.03 0.03 0.43 TRUE
27 GTEx Ovary ARL16 0.48 0.33 enet 4 0.40 4.6e-11 5.0 -6.0 2.0e-09 -0.29 0.97 0.00 FALSE
28 GTEx Pancreas ARL16 0.54 0.53 lasso 2 0.56 9.1e-28 6.4 -6.2 5.2e-10 -0.30 1.00 0.00 FALSE
29 GTEx Pituitary ARL16 0.53 0.48 lasso 3 0.47 1.6e-13 5.0 -5.9 4.6e-09 -0.29 0.99 0.00 FALSE
30 GTEx Prostate ARL16 0.53 0.46 lasso 4 0.42 9.3e-12 5.0 -5.6 2.5e-08 -0.28 0.99 0.00 FALSE
31 GTEx Skin Not Sun Exposed Suprapubic ARL16 0.57 0.49 lasso 5 0.51 4.0e-32 5.0 -5.8 5.7e-09 -0.29 1.00 0.00 FALSE
32 GTEx Skin Sun Exposed Lower leg ARL16 0.51 0.58 lasso 2 0.61 2.6e-63 5.0 -5.8 6.7e-09 -0.28 1.00 0.00 FALSE
33 GTEx Stomach ARL16 0.55 0.57 lasso 3 0.57 1.1e-32 5.0 -5.7 1.4e-08 -0.28 1.00 0.00 FALSE
34 GTEx Testis P4HB 0.28 0.17 enet 5 0.15 2.9e-07 -5.8 -6.0 1.5e-09 -0.07 0.97 0.00 FALSE
35 GTEx Testis RP11-498C9.2 0.29 0.19 lasso 3 0.19 1.1e-08 -6.0 -6.0 1.8e-09 -0.07 1.00 0.00 FALSE
36 GTEx Thyroid ASPSCR1 0.23 0.15 enet 19 0.09 1.2e-07 -5.5 6.6 4.1e-11 0.02 1.00 0.00 TRUE
37 GTEx Uterus ARL16 0.78 0.60 lasso 5 0.47 4.1e-11 5.0 -5.2 2.0e-07 -0.27 0.96 0.01 FALSE
38 GTEx Vagina ARL16 0.54 0.51 lasso 3 0.42 7.2e-11 5.0 -5.3 1.0e-07 -0.26 0.96 0.01 FALSE
39 NTR Blood ARL16 0.03 0.02 enet 10 0.02 1.5e-08 5.8 -5.1 2.9e-07 -0.29 1.00 0.00 FALSE
40 YFS Blood ASPSCR1 0.11 0.07 lasso 9 0.06 7.9e-20 -5.0 5.8 5.3e-09 0.07 1.00 0.00 FALSE
41 YFS Blood NPLOC4 0.13 0.04 enet 38 0.08 3.1e-26 5.2 6.3 3.0e-10 0.41 0.02 0.98 FALSE
42 The Cancer Genome Atlas Bladder Urothelial Carcinoma ARL16 0.30 0.25 enet 7 0.28 9.8e-24 4.7 -5.7 1.0e-08 -0.31 0.99 0.01 FALSE
43 The Cancer Genome Atlas Bladder Urothelial Carcinoma DYSFIP1 0.04 0.02 blup 7 0.02 1.0e-02 -6.0 -6.1 1.4e-09 -0.07 0.00 0.86 FALSE
44 The Cancer Genome Atlas Breast Invasive Carcinoma ARL16 0.21 0.28 lasso 4 0.27 1.4e-55 5.0 -5.3 1.1e-07 -0.26 0.99 0.01 FALSE
45 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma ARL16 0.22 0.26 lasso 8 0.27 1.1e-13 5.9 -5.9 3.7e-09 -0.29 0.09 0.91 FALSE
46 The Cancer Genome Atlas Colon Adenocarcinoma ARL16 0.30 0.31 lasso 9 0.30 1.8e-17 5.0 -5.2 1.9e-07 -0.26 0.68 0.32 FALSE
47 The Cancer Genome Atlas Colon Adenocarcinoma C17orf90 0.06 0.01 blup 51 0.02 1.4e-02 3.4 -5.9 4.0e-09 -0.21 0.03 0.66 FALSE
48 The Cancer Genome Atlas Colon Adenocarcinoma DYSFIP1 0.09 0.03 enet 7 0.04 1.8e-03 -6.0 5.4 8.4e-08 0.05 0.00 0.80 FALSE
49 The Cancer Genome Atlas Esophageal Carcinoma ARL16 0.27 0.23 blup 52 0.18 1.7e-06 5.0 -6.3 3.8e-10 -0.27 0.13 0.86 FALSE
50 The Cancer Genome Atlas Glioblastoma Multiforme ARL16 0.28 0.35 lasso 5 0.33 9.2e-11 5.0 -5.2 2.0e-07 -0.30 0.19 0.81 FALSE
51 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ARL16 0.28 0.30 lasso 4 0.33 9.7e-38 5.0 -5.2 1.5e-07 -0.29 0.99 0.01 FALSE
52 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma PYCR1 0.02 0.01 blup 9 0.01 1.1e-02 -4.3 5.3 1.1e-07 0.01 0.01 0.30 FALSE
53 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma THOC4 0.28 0.02 lasso 2 0.02 1.8e-03 -6.0 -6.0 2.0e-09 -0.07 0.00 0.75 FALSE
54 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ARHGDIA 0.02 0.02 lasso 2 0.01 1.1e-02 -6.1 6.1 1.2e-09 0.07 0.00 0.68 FALSE
55 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ARL16 0.17 0.15 lasso 6 0.20 1.8e-22 4.8 -5.7 1.5e-08 -0.33 0.24 0.76 FALSE
56 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma ARL16 0.41 0.36 enet 12 0.40 1.8e-24 5.0 -5.6 1.7e-08 -0.28 0.05 0.95 FALSE
57 The Cancer Genome Atlas Brain Lower Grade Glioma MYADML2 0.03 0.03 blup 10 0.03 1.1e-04 -5.0 -5.5 3.2e-08 -0.02 0.01 0.96 FALSE
58 The Cancer Genome Atlas Liver Hepatocellular Carcinoma ARL16 0.27 0.24 lasso 6 0.29 2.9e-14 6.1 -6.3 3.0e-10 -0.33 0.07 0.93 FALSE
59 The Cancer Genome Atlas Lung Adenocarcinoma ARL16 0.26 0.32 lasso 4 0.32 1.5e-37 5.0 -5.4 7.6e-08 -0.28 0.99 0.01 FALSE
60 The Cancer Genome Atlas Lung Squamous Cell Carcinoma ARL16 0.15 0.18 lasso 5 0.22 6.8e-25 4.8 -5.8 5.4e-09 -0.32 0.56 0.44 FALSE
61 The Cancer Genome Atlas Lung Squamous Cell Carcinoma DYSFIP1 0.03 0.02 blup 7 0.02 7.0e-04 -6.1 -6.1 1.4e-09 -0.07 0.00 0.90 FALSE
62 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SLC25A10 0.03 0.02 enet 6 0.03 5.1e-04 6.0 7.0 1.9e-12 0.28 0.05 0.83 TRUE
63 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma DYSFIP1 0.04 0.02 enet 2 0.02 1.2e-02 -6.1 6.1 1.1e-09 0.07 0.00 0.63 TRUE
64 The Cancer Genome Atlas Pancreatic Adenocarcinoma ARL16 0.45 0.42 lasso 9 0.40 4.8e-18 5.0 -5.2 2.6e-07 -0.26 0.86 0.14 FALSE
65 The Cancer Genome Atlas Prostate Adenocarcinoma ARL16 0.52 0.40 lasso 6 0.48 6.1e-56 5.0 -5.7 1.2e-08 -0.30 0.94 0.06 FALSE
66 The Cancer Genome Atlas Rectum Adenocarcinoma ARL16 0.37 0.29 blup 52 0.36 2.3e-09 4.7 -5.4 8.2e-08 -0.31 0.10 0.89 FALSE
67 The Cancer Genome Atlas Soft Tissue Sarcoma ARL16 0.14 0.17 lasso 2 0.15 2.5e-09 5.0 -5.5 3.5e-08 -0.26 0.35 0.65 FALSE
68 The Cancer Genome Atlas Stomach Adenocarcinoma ARL16 0.21 0.14 blup 52 0.20 3.6e-14 4.8 -5.3 1.4e-07 -0.28 0.14 0.86 FALSE
69 The Cancer Genome Atlas Testicular Germ Cell Tumors ARL16 0.31 0.19 blup 52 0.30 3.7e-11 5.0 -6.5 1.1e-10 -0.29 0.19 0.81 FALSE
70 The Cancer Genome Atlas Thyroid Carcinoma ARL16 0.29 0.37 lasso 7 0.38 2.9e-39 5.0 -5.6 1.8e-08 -0.28 0.99 0.01 FALSE
71 The Cancer Genome Atlas Thyroid Carcinoma SLC25A10 0.06 0.03 blup 39 0.06 2.3e-06 6.3 7.0 3.2e-12 0.32 0.09 0.90 FALSE