Best TWAS P=1.89e-12 · Best GWAS P=3.86e-22 conditioned to 3.32e-13
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CCDC137 | 0.12 | 0.09 | enet | 14 | 0.10 | 9.6e-13 | 6.1 | 6.5 | 9.7e-11 | 0.34 | 1.00 | 0.00 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | MRPL12 | 0.04 | 0.02 | lasso | 4 | 0.03 | 3.8e-04 | 3.5 | 5.5 | 3.5e-08 | 0.21 | 0.32 | 0.02 | FALSE |
3 | GTEx | Adipose Subcutaneous | CCDC137 | 0.14 | 0.06 | lasso | 2 | 0.07 | 1.3e-06 | 6.5 | -5.8 | 7.1e-09 | -0.25 | 0.85 | 0.01 | FALSE |
4 | GTEx | Adipose Subcutaneous | ARL16 | 0.46 | 0.49 | lasso | 5 | 0.51 | 3.1e-48 | 5.0 | -5.5 | 3.6e-08 | -0.28 | 1.00 | 0.00 | FALSE |
5 | GTEx | Artery Aorta | STRA13 | 0.20 | 0.14 | enet | 16 | 0.11 | 7.9e-07 | -2.4 | 5.6 | 2.3e-08 | 0.16 | 0.84 | 0.01 | FALSE |
6 | GTEx | Artery Aorta | ARL16 | 0.51 | 0.46 | enet | 13 | 0.46 | 7.0e-28 | 5.0 | -5.4 | 5.5e-08 | -0.28 | 1.00 | 0.00 | FALSE |
7 | GTEx | Artery Coronary | ARL16 | 0.61 | 0.38 | lasso | 7 | 0.37 | 1.4e-13 | 5.0 | -5.3 | 1.0e-07 | -0.27 | 1.00 | 0.00 | FALSE |
8 | GTEx | Artery Tibial | LRRC45 | 0.09 | 0.07 | lasso | 4 | 0.04 | 2.0e-04 | -4.7 | 6.2 | 5.0e-10 | 0.05 | 0.84 | 0.01 | FALSE |
9 | GTEx | Artery Tibial | ARL16 | 0.40 | 0.40 | lasso | 3 | 0.39 | 1.2e-32 | 5.0 | -5.2 | 2.0e-07 | -0.26 | 1.00 | 0.00 | FALSE |
10 | GTEx | Brain Caudate basal ganglia | ARL16 | 0.43 | 0.27 | enet | 6 | 0.34 | 1.1e-10 | 5.0 | -5.7 | 1.2e-08 | -0.28 | 0.97 | 0.00 | FALSE |
11 | GTEx | Brain Cerebellar Hemisphere | ARL16 | 0.33 | 0.25 | lasso | 5 | 0.25 | 4.2e-07 | 4.8 | -5.4 | 5.2e-08 | -0.31 | 0.90 | 0.03 | FALSE |
12 | GTEx | Brain Cerebellum | NARF | 0.20 | 0.07 | enet | 19 | 0.03 | 4.2e-02 | 3.4 | -5.3 | 9.5e-08 | 0.03 | 0.12 | 0.05 | FALSE |
13 | GTEx | Brain Cerebellum | ARL16 | 0.43 | 0.20 | lasso | 8 | 0.20 | 1.2e-06 | 5.0 | -6.0 | 1.5e-09 | -0.31 | 0.88 | 0.04 | FALSE |
14 | GTEx | Brain Hippocampus | ARL16 | 0.30 | 0.31 | lasso | 3 | 0.31 | 4.4e-08 | 5.0 | -5.5 | 4.6e-08 | -0.28 | 0.70 | 0.07 | FALSE |
15 | GTEx | Brain Nucleus accumbens basal ganglia | ARL16 | 0.25 | 0.27 | lasso | 3 | 0.24 | 5.8e-07 | 5.0 | -5.3 | 1.3e-07 | -0.27 | 0.50 | 0.12 | FALSE |
16 | GTEx | Brain Putamen basal ganglia | ARL16 | 0.23 | 0.18 | lasso | 4 | 0.16 | 1.4e-04 | 5.0 | -6.1 | 9.1e-10 | -0.28 | 0.12 | 0.06 | FALSE |
17 | GTEx | Breast Mammary Tissue (Female) | NPLOC4 | 0.04 | -0.01 | lasso | 2 | -0.01 | 7.7e-01 | 5.2 | -5.2 | 2.4e-07 | -0.31 | 0.03 | 0.06 | FALSE |
18 | GTEx | Cells Transformed fibroblasts | HGS | 0.09 | 0.11 | lasso | 3 | 0.10 | 5.9e-08 | 6.3 | -6.0 | 2.0e-09 | -0.30 | 0.98 | 0.00 | FALSE |
19 | GTEx | Colon Transverse | ARL16 | 0.58 | 0.56 | enet | 15 | 0.59 | 3.9e-34 | 5.0 | -6.1 | 1.4e-09 | -0.29 | 1.00 | 0.00 | FALSE |
20 | GTEx | Esophagus Gastroesophageal Junction | ARL16 | 0.69 | 0.53 | lasso | 6 | 0.53 | 2.8e-22 | 5.0 | -5.4 | 8.2e-08 | -0.28 | 1.00 | 0.00 | FALSE |
21 | GTEx | Esophagus Mucosa | ARL16 | 0.58 | 0.54 | enet | 35 | 0.63 | 5.3e-53 | 5.0 | -5.3 | 9.8e-08 | -0.27 | 1.00 | 0.00 | FALSE |
22 | GTEx | Heart Atrial Appendage | LRRC45 | 0.19 | 0.06 | enet | 9 | 0.12 | 6.7e-06 | -5.8 | 5.5 | 3.4e-08 | 0.03 | 0.75 | 0.01 | FALSE |
23 | GTEx | Lung | NPLOC4 | 0.11 | 0.07 | lasso | 1 | 0.04 | 3.2e-04 | 5.3 | -5.3 | 1.1e-07 | -0.31 | 0.44 | 0.03 | FALSE |
24 | GTEx | Nerve Tibial | NPLOC4 | 0.13 | 0.03 | lasso | 2 | 0.03 | 3.0e-03 | 5.3 | -5.7 | 1.3e-08 | -0.26 | 0.17 | 0.03 | FALSE |
25 | GTEx | Nerve Tibial | ARL16 | 0.60 | 0.43 | enet | 18 | 0.50 | 5.8e-40 | 5.0 | -5.6 | 2.1e-08 | -0.27 | 1.00 | 0.00 | FALSE |
26 | GTEx | Ovary | RAB40B | 0.31 | -0.01 | enet | 28 | 0.04 | 4.1e-02 | 2.4 | -5.7 | 1.0e-08 | -0.03 | 0.03 | 0.43 | TRUE |
27 | GTEx | Ovary | ARL16 | 0.48 | 0.33 | enet | 4 | 0.40 | 4.6e-11 | 5.0 | -6.0 | 2.0e-09 | -0.29 | 0.97 | 0.00 | FALSE |
28 | GTEx | Pancreas | ARL16 | 0.54 | 0.53 | lasso | 2 | 0.56 | 9.1e-28 | 6.4 | -6.2 | 5.2e-10 | -0.30 | 1.00 | 0.00 | FALSE |
29 | GTEx | Pituitary | ARL16 | 0.53 | 0.48 | lasso | 3 | 0.47 | 1.6e-13 | 5.0 | -5.9 | 4.6e-09 | -0.29 | 0.99 | 0.00 | FALSE |
30 | GTEx | Prostate | ARL16 | 0.53 | 0.46 | lasso | 4 | 0.42 | 9.3e-12 | 5.0 | -5.6 | 2.5e-08 | -0.28 | 0.99 | 0.00 | FALSE |
31 | GTEx | Skin Not Sun Exposed Suprapubic | ARL16 | 0.57 | 0.49 | lasso | 5 | 0.51 | 4.0e-32 | 5.0 | -5.8 | 5.7e-09 | -0.29 | 1.00 | 0.00 | FALSE |
32 | GTEx | Skin Sun Exposed Lower leg | ARL16 | 0.51 | 0.58 | lasso | 2 | 0.61 | 2.6e-63 | 5.0 | -5.8 | 6.7e-09 | -0.28 | 1.00 | 0.00 | FALSE |
33 | GTEx | Stomach | ARL16 | 0.55 | 0.57 | lasso | 3 | 0.57 | 1.1e-32 | 5.0 | -5.7 | 1.4e-08 | -0.28 | 1.00 | 0.00 | FALSE |
34 | GTEx | Testis | P4HB | 0.28 | 0.17 | enet | 5 | 0.15 | 2.9e-07 | -5.8 | -6.0 | 1.5e-09 | -0.07 | 0.97 | 0.00 | FALSE |
35 | GTEx | Testis | RP11-498C9.2 | 0.29 | 0.19 | lasso | 3 | 0.19 | 1.1e-08 | -6.0 | -6.0 | 1.8e-09 | -0.07 | 1.00 | 0.00 | FALSE |
36 | GTEx | Thyroid | ASPSCR1 | 0.23 | 0.15 | enet | 19 | 0.09 | 1.2e-07 | -5.5 | 6.6 | 4.1e-11 | 0.02 | 1.00 | 0.00 | TRUE |
37 | GTEx | Uterus | ARL16 | 0.78 | 0.60 | lasso | 5 | 0.47 | 4.1e-11 | 5.0 | -5.2 | 2.0e-07 | -0.27 | 0.96 | 0.01 | FALSE |
38 | GTEx | Vagina | ARL16 | 0.54 | 0.51 | lasso | 3 | 0.42 | 7.2e-11 | 5.0 | -5.3 | 1.0e-07 | -0.26 | 0.96 | 0.01 | FALSE |
39 | NTR | Blood | ARL16 | 0.03 | 0.02 | enet | 10 | 0.02 | 1.5e-08 | 5.8 | -5.1 | 2.9e-07 | -0.29 | 1.00 | 0.00 | FALSE |
40 | YFS | Blood | ASPSCR1 | 0.11 | 0.07 | lasso | 9 | 0.06 | 7.9e-20 | -5.0 | 5.8 | 5.3e-09 | 0.07 | 1.00 | 0.00 | FALSE |
41 | YFS | Blood | NPLOC4 | 0.13 | 0.04 | enet | 38 | 0.08 | 3.1e-26 | 5.2 | 6.3 | 3.0e-10 | 0.41 | 0.02 | 0.98 | FALSE |
42 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ARL16 | 0.30 | 0.25 | enet | 7 | 0.28 | 9.8e-24 | 4.7 | -5.7 | 1.0e-08 | -0.31 | 0.99 | 0.01 | FALSE |
43 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | DYSFIP1 | 0.04 | 0.02 | blup | 7 | 0.02 | 1.0e-02 | -6.0 | -6.1 | 1.4e-09 | -0.07 | 0.00 | 0.86 | FALSE |
44 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ARL16 | 0.21 | 0.28 | lasso | 4 | 0.27 | 1.4e-55 | 5.0 | -5.3 | 1.1e-07 | -0.26 | 0.99 | 0.01 | FALSE |
45 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | ARL16 | 0.22 | 0.26 | lasso | 8 | 0.27 | 1.1e-13 | 5.9 | -5.9 | 3.7e-09 | -0.29 | 0.09 | 0.91 | FALSE |
46 | The Cancer Genome Atlas | Colon Adenocarcinoma | ARL16 | 0.30 | 0.31 | lasso | 9 | 0.30 | 1.8e-17 | 5.0 | -5.2 | 1.9e-07 | -0.26 | 0.68 | 0.32 | FALSE |
47 | The Cancer Genome Atlas | Colon Adenocarcinoma | C17orf90 | 0.06 | 0.01 | blup | 51 | 0.02 | 1.4e-02 | 3.4 | -5.9 | 4.0e-09 | -0.21 | 0.03 | 0.66 | FALSE |
48 | The Cancer Genome Atlas | Colon Adenocarcinoma | DYSFIP1 | 0.09 | 0.03 | enet | 7 | 0.04 | 1.8e-03 | -6.0 | 5.4 | 8.4e-08 | 0.05 | 0.00 | 0.80 | FALSE |
49 | The Cancer Genome Atlas | Esophageal Carcinoma | ARL16 | 0.27 | 0.23 | blup | 52 | 0.18 | 1.7e-06 | 5.0 | -6.3 | 3.8e-10 | -0.27 | 0.13 | 0.86 | FALSE |
50 | The Cancer Genome Atlas | Glioblastoma Multiforme | ARL16 | 0.28 | 0.35 | lasso | 5 | 0.33 | 9.2e-11 | 5.0 | -5.2 | 2.0e-07 | -0.30 | 0.19 | 0.81 | FALSE |
51 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ARL16 | 0.28 | 0.30 | lasso | 4 | 0.33 | 9.7e-38 | 5.0 | -5.2 | 1.5e-07 | -0.29 | 0.99 | 0.01 | FALSE |
52 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PYCR1 | 0.02 | 0.01 | blup | 9 | 0.01 | 1.1e-02 | -4.3 | 5.3 | 1.1e-07 | 0.01 | 0.01 | 0.30 | FALSE |
53 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | THOC4 | 0.28 | 0.02 | lasso | 2 | 0.02 | 1.8e-03 | -6.0 | -6.0 | 2.0e-09 | -0.07 | 0.00 | 0.75 | FALSE |
54 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ARHGDIA | 0.02 | 0.02 | lasso | 2 | 0.01 | 1.1e-02 | -6.1 | 6.1 | 1.2e-09 | 0.07 | 0.00 | 0.68 | FALSE |
55 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ARL16 | 0.17 | 0.15 | lasso | 6 | 0.20 | 1.8e-22 | 4.8 | -5.7 | 1.5e-08 | -0.33 | 0.24 | 0.76 | FALSE |
56 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ARL16 | 0.41 | 0.36 | enet | 12 | 0.40 | 1.8e-24 | 5.0 | -5.6 | 1.7e-08 | -0.28 | 0.05 | 0.95 | FALSE |
57 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MYADML2 | 0.03 | 0.03 | blup | 10 | 0.03 | 1.1e-04 | -5.0 | -5.5 | 3.2e-08 | -0.02 | 0.01 | 0.96 | FALSE |
58 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ARL16 | 0.27 | 0.24 | lasso | 6 | 0.29 | 2.9e-14 | 6.1 | -6.3 | 3.0e-10 | -0.33 | 0.07 | 0.93 | FALSE |
59 | The Cancer Genome Atlas | Lung Adenocarcinoma | ARL16 | 0.26 | 0.32 | lasso | 4 | 0.32 | 1.5e-37 | 5.0 | -5.4 | 7.6e-08 | -0.28 | 0.99 | 0.01 | FALSE |
60 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ARL16 | 0.15 | 0.18 | lasso | 5 | 0.22 | 6.8e-25 | 4.8 | -5.8 | 5.4e-09 | -0.32 | 0.56 | 0.44 | FALSE |
61 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | DYSFIP1 | 0.03 | 0.02 | blup | 7 | 0.02 | 7.0e-04 | -6.1 | -6.1 | 1.4e-09 | -0.07 | 0.00 | 0.90 | FALSE |
62 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SLC25A10 | 0.03 | 0.02 | enet | 6 | 0.03 | 5.1e-04 | 6.0 | 7.0 | 1.9e-12 | 0.28 | 0.05 | 0.83 | TRUE |
63 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | DYSFIP1 | 0.04 | 0.02 | enet | 2 | 0.02 | 1.2e-02 | -6.1 | 6.1 | 1.1e-09 | 0.07 | 0.00 | 0.63 | TRUE |
64 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ARL16 | 0.45 | 0.42 | lasso | 9 | 0.40 | 4.8e-18 | 5.0 | -5.2 | 2.6e-07 | -0.26 | 0.86 | 0.14 | FALSE |
65 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ARL16 | 0.52 | 0.40 | lasso | 6 | 0.48 | 6.1e-56 | 5.0 | -5.7 | 1.2e-08 | -0.30 | 0.94 | 0.06 | FALSE |
66 | The Cancer Genome Atlas | Rectum Adenocarcinoma | ARL16 | 0.37 | 0.29 | blup | 52 | 0.36 | 2.3e-09 | 4.7 | -5.4 | 8.2e-08 | -0.31 | 0.10 | 0.89 | FALSE |
67 | The Cancer Genome Atlas | Soft Tissue Sarcoma | ARL16 | 0.14 | 0.17 | lasso | 2 | 0.15 | 2.5e-09 | 5.0 | -5.5 | 3.5e-08 | -0.26 | 0.35 | 0.65 | FALSE |
68 | The Cancer Genome Atlas | Stomach Adenocarcinoma | ARL16 | 0.21 | 0.14 | blup | 52 | 0.20 | 3.6e-14 | 4.8 | -5.3 | 1.4e-07 | -0.28 | 0.14 | 0.86 | FALSE |
69 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | ARL16 | 0.31 | 0.19 | blup | 52 | 0.30 | 3.7e-11 | 5.0 | -6.5 | 1.1e-10 | -0.29 | 0.19 | 0.81 | FALSE |
70 | The Cancer Genome Atlas | Thyroid Carcinoma | ARL16 | 0.29 | 0.37 | lasso | 7 | 0.38 | 2.9e-39 | 5.0 | -5.6 | 1.8e-08 | -0.28 | 0.99 | 0.01 | FALSE |
71 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC25A10 | 0.06 | 0.03 | blup | 39 | 0.06 | 2.3e-06 | 6.3 | 7.0 | 3.2e-12 | 0.32 | 0.09 | 0.90 | FALSE |