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chr17:78,826,134-81,051,007

Best TWAS P=1.89e-12 · Best GWAS P=3.86e-22 conditioned to 3.32e-13

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CCDC137	0.12	0.09	enet	14	0.10	9.6e-13	6.1	6.5	9.7e-11	0.34	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MRPL12	0.04	0.02	lasso	4	0.03	3.8e-04	3.5	5.5	3.5e-08	0.21	0.32	0.02	FALSE
3	GTEx	Adipose Subcutaneous	CCDC137	0.14	0.06	lasso	2	0.07	1.3e-06	6.5	-5.8	7.1e-09	-0.25	0.85	0.01	FALSE
4	GTEx	Adipose Subcutaneous	ARL16	0.46	0.49	lasso	5	0.51	3.1e-48	5.0	-5.5	3.6e-08	-0.28	1.00	0.00	FALSE
5	GTEx	Artery Aorta	STRA13	0.20	0.14	enet	16	0.11	7.9e-07	-2.4	5.6	2.3e-08	0.16	0.84	0.01	FALSE
6	GTEx	Artery Aorta	ARL16	0.51	0.46	enet	13	0.46	7.0e-28	5.0	-5.4	5.5e-08	-0.28	1.00	0.00	FALSE
7	GTEx	Artery Coronary	ARL16	0.61	0.38	lasso	7	0.37	1.4e-13	5.0	-5.3	1.0e-07	-0.27	1.00	0.00	FALSE
8	GTEx	Artery Tibial	LRRC45	0.09	0.07	lasso	4	0.04	2.0e-04	-4.7	6.2	5.0e-10	0.05	0.84	0.01	FALSE
9	GTEx	Artery Tibial	ARL16	0.40	0.40	lasso	3	0.39	1.2e-32	5.0	-5.2	2.0e-07	-0.26	1.00	0.00	FALSE
10	GTEx	Brain Caudate basal ganglia	ARL16	0.43	0.27	enet	6	0.34	1.1e-10	5.0	-5.7	1.2e-08	-0.28	0.97	0.00	FALSE
11	GTEx	Brain Cerebellar Hemisphere	ARL16	0.33	0.25	lasso	5	0.25	4.2e-07	4.8	-5.4	5.2e-08	-0.31	0.90	0.03	FALSE
12	GTEx	Brain Cerebellum	NARF	0.20	0.07	enet	19	0.03	4.2e-02	3.4	-5.3	9.5e-08	0.03	0.12	0.05	FALSE
13	GTEx	Brain Cerebellum	ARL16	0.43	0.20	lasso	8	0.20	1.2e-06	5.0	-6.0	1.5e-09	-0.31	0.88	0.04	FALSE
14	GTEx	Brain Hippocampus	ARL16	0.30	0.31	lasso	3	0.31	4.4e-08	5.0	-5.5	4.6e-08	-0.28	0.70	0.07	FALSE
15	GTEx	Brain Nucleus accumbens basal ganglia	ARL16	0.25	0.27	lasso	3	0.24	5.8e-07	5.0	-5.3	1.3e-07	-0.27	0.50	0.12	FALSE
16	GTEx	Brain Putamen basal ganglia	ARL16	0.23	0.18	lasso	4	0.16	1.4e-04	5.0	-6.1	9.1e-10	-0.28	0.12	0.06	FALSE
17	GTEx	Breast Mammary Tissue (Female)	NPLOC4	0.04	-0.01	lasso	2	-0.01	7.7e-01	5.2	-5.2	2.4e-07	-0.31	0.03	0.06	FALSE
18	GTEx	Cells Transformed fibroblasts	HGS	0.09	0.11	lasso	3	0.10	5.9e-08	6.3	-6.0	2.0e-09	-0.30	0.98	0.00	FALSE
19	GTEx	Colon Transverse	ARL16	0.58	0.56	enet	15	0.59	3.9e-34	5.0	-6.1	1.4e-09	-0.29	1.00	0.00	FALSE
20	GTEx	Esophagus Gastroesophageal Junction	ARL16	0.69	0.53	lasso	6	0.53	2.8e-22	5.0	-5.4	8.2e-08	-0.28	1.00	0.00	FALSE
21	GTEx	Esophagus Mucosa	ARL16	0.58	0.54	enet	35	0.63	5.3e-53	5.0	-5.3	9.8e-08	-0.27	1.00	0.00	FALSE
22	GTEx	Heart Atrial Appendage	LRRC45	0.19	0.06	enet	9	0.12	6.7e-06	-5.8	5.5	3.4e-08	0.03	0.75	0.01	FALSE
23	GTEx	Lung	NPLOC4	0.11	0.07	lasso	1	0.04	3.2e-04	5.3	-5.3	1.1e-07	-0.31	0.44	0.03	FALSE
24	GTEx	Nerve Tibial	NPLOC4	0.13	0.03	lasso	2	0.03	3.0e-03	5.3	-5.7	1.3e-08	-0.26	0.17	0.03	FALSE
25	GTEx	Nerve Tibial	ARL16	0.60	0.43	enet	18	0.50	5.8e-40	5.0	-5.6	2.1e-08	-0.27	1.00	0.00	FALSE
26	GTEx	Ovary	RAB40B	0.31	-0.01	enet	28	0.04	4.1e-02	2.4	-5.7	1.0e-08	-0.03	0.03	0.43	TRUE
27	GTEx	Ovary	ARL16	0.48	0.33	enet	4	0.40	4.6e-11	5.0	-6.0	2.0e-09	-0.29	0.97	0.00	FALSE
28	GTEx	Pancreas	ARL16	0.54	0.53	lasso	2	0.56	9.1e-28	6.4	-6.2	5.2e-10	-0.30	1.00	0.00	FALSE
29	GTEx	Pituitary	ARL16	0.53	0.48	lasso	3	0.47	1.6e-13	5.0	-5.9	4.6e-09	-0.29	0.99	0.00	FALSE
30	GTEx	Prostate	ARL16	0.53	0.46	lasso	4	0.42	9.3e-12	5.0	-5.6	2.5e-08	-0.28	0.99	0.00	FALSE
31	GTEx	Skin Not Sun Exposed Suprapubic	ARL16	0.57	0.49	lasso	5	0.51	4.0e-32	5.0	-5.8	5.7e-09	-0.29	1.00	0.00	FALSE
32	GTEx	Skin Sun Exposed Lower leg	ARL16	0.51	0.58	lasso	2	0.61	2.6e-63	5.0	-5.8	6.7e-09	-0.28	1.00	0.00	FALSE
33	GTEx	Stomach	ARL16	0.55	0.57	lasso	3	0.57	1.1e-32	5.0	-5.7	1.4e-08	-0.28	1.00	0.00	FALSE
34	GTEx	Testis	P4HB	0.28	0.17	enet	5	0.15	2.9e-07	-5.8	-6.0	1.5e-09	-0.07	0.97	0.00	FALSE
35	GTEx	Testis	RP11-498C9.2	0.29	0.19	lasso	3	0.19	1.1e-08	-6.0	-6.0	1.8e-09	-0.07	1.00	0.00	FALSE
36	GTEx	Thyroid	ASPSCR1	0.23	0.15	enet	19	0.09	1.2e-07	-5.5	6.6	4.1e-11	0.02	1.00	0.00	TRUE
37	GTEx	Uterus	ARL16	0.78	0.60	lasso	5	0.47	4.1e-11	5.0	-5.2	2.0e-07	-0.27	0.96	0.01	FALSE
38	GTEx	Vagina	ARL16	0.54	0.51	lasso	3	0.42	7.2e-11	5.0	-5.3	1.0e-07	-0.26	0.96	0.01	FALSE
39	NTR	Blood	ARL16	0.03	0.02	enet	10	0.02	1.5e-08	5.8	-5.1	2.9e-07	-0.29	1.00	0.00	FALSE
40	YFS	Blood	ASPSCR1	0.11	0.07	lasso	9	0.06	7.9e-20	-5.0	5.8	5.3e-09	0.07	1.00	0.00	FALSE
41	YFS	Blood	NPLOC4	0.13	0.04	enet	38	0.08	3.1e-26	5.2	6.3	3.0e-10	0.41	0.02	0.98	FALSE
42	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ARL16	0.30	0.25	enet	7	0.28	9.8e-24	4.7	-5.7	1.0e-08	-0.31	0.99	0.01	FALSE
43	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	DYSFIP1	0.04	0.02	blup	7	0.02	1.0e-02	-6.0	-6.1	1.4e-09	-0.07	0.00	0.86	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	ARL16	0.21	0.28	lasso	4	0.27	1.4e-55	5.0	-5.3	1.1e-07	-0.26	0.99	0.01	FALSE
45	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ARL16	0.22	0.26	lasso	8	0.27	1.1e-13	5.9	-5.9	3.7e-09	-0.29	0.09	0.91	FALSE
46	The Cancer Genome Atlas	Colon Adenocarcinoma	ARL16	0.30	0.31	lasso	9	0.30	1.8e-17	5.0	-5.2	1.9e-07	-0.26	0.68	0.32	FALSE
47	The Cancer Genome Atlas	Colon Adenocarcinoma	C17orf90	0.06	0.01	blup	51	0.02	1.4e-02	3.4	-5.9	4.0e-09	-0.21	0.03	0.66	FALSE
48	The Cancer Genome Atlas	Colon Adenocarcinoma	DYSFIP1	0.09	0.03	enet	7	0.04	1.8e-03	-6.0	5.4	8.4e-08	0.05	0.00	0.80	FALSE
49	The Cancer Genome Atlas	Esophageal Carcinoma	ARL16	0.27	0.23	blup	52	0.18	1.7e-06	5.0	-6.3	3.8e-10	-0.27	0.13	0.86	FALSE
50	The Cancer Genome Atlas	Glioblastoma Multiforme	ARL16	0.28	0.35	lasso	5	0.33	9.2e-11	5.0	-5.2	2.0e-07	-0.30	0.19	0.81	FALSE
51	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ARL16	0.28	0.30	lasso	4	0.33	9.7e-38	5.0	-5.2	1.5e-07	-0.29	0.99	0.01	FALSE
52	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PYCR1	0.02	0.01	blup	9	0.01	1.1e-02	-4.3	5.3	1.1e-07	0.01	0.01	0.30	FALSE
53	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	THOC4	0.28	0.02	lasso	2	0.02	1.8e-03	-6.0	-6.0	2.0e-09	-0.07	0.00	0.75	FALSE
54	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ARHGDIA	0.02	0.02	lasso	2	0.01	1.1e-02	-6.1	6.1	1.2e-09	0.07	0.00	0.68	FALSE
55	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ARL16	0.17	0.15	lasso	6	0.20	1.8e-22	4.8	-5.7	1.5e-08	-0.33	0.24	0.76	FALSE
56	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ARL16	0.41	0.36	enet	12	0.40	1.8e-24	5.0	-5.6	1.7e-08	-0.28	0.05	0.95	FALSE
57	The Cancer Genome Atlas	Brain Lower Grade Glioma	MYADML2	0.03	0.03	blup	10	0.03	1.1e-04	-5.0	-5.5	3.2e-08	-0.02	0.01	0.96	FALSE
58	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ARL16	0.27	0.24	lasso	6	0.29	2.9e-14	6.1	-6.3	3.0e-10	-0.33	0.07	0.93	FALSE
59	The Cancer Genome Atlas	Lung Adenocarcinoma	ARL16	0.26	0.32	lasso	4	0.32	1.5e-37	5.0	-5.4	7.6e-08	-0.28	0.99	0.01	FALSE
60	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ARL16	0.15	0.18	lasso	5	0.22	6.8e-25	4.8	-5.8	5.4e-09	-0.32	0.56	0.44	FALSE
61	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DYSFIP1	0.03	0.02	blup	7	0.02	7.0e-04	-6.1	-6.1	1.4e-09	-0.07	0.00	0.90	FALSE
62	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC25A10	0.03	0.02	enet	6	0.03	5.1e-04	6.0	7.0	1.9e-12	0.28	0.05	0.83	TRUE
63	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	DYSFIP1	0.04	0.02	enet	2	0.02	1.2e-02	-6.1	6.1	1.1e-09	0.07	0.00	0.63	TRUE
64	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ARL16	0.45	0.42	lasso	9	0.40	4.8e-18	5.0	-5.2	2.6e-07	-0.26	0.86	0.14	FALSE
65	The Cancer Genome Atlas	Prostate Adenocarcinoma	ARL16	0.52	0.40	lasso	6	0.48	6.1e-56	5.0	-5.7	1.2e-08	-0.30	0.94	0.06	FALSE
66	The Cancer Genome Atlas	Rectum Adenocarcinoma	ARL16	0.37	0.29	blup	52	0.36	2.3e-09	4.7	-5.4	8.2e-08	-0.31	0.10	0.89	FALSE
67	The Cancer Genome Atlas	Soft Tissue Sarcoma	ARL16	0.14	0.17	lasso	2	0.15	2.5e-09	5.0	-5.5	3.5e-08	-0.26	0.35	0.65	FALSE
68	The Cancer Genome Atlas	Stomach Adenocarcinoma	ARL16	0.21	0.14	blup	52	0.20	3.6e-14	4.8	-5.3	1.4e-07	-0.28	0.14	0.86	FALSE
69	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ARL16	0.31	0.19	blup	52	0.30	3.7e-11	5.0	-6.5	1.1e-10	-0.29	0.19	0.81	FALSE
70	The Cancer Genome Atlas	Thyroid Carcinoma	ARL16	0.29	0.37	lasso	7	0.38	2.9e-39	5.0	-5.6	1.8e-08	-0.28	0.99	0.01	FALSE
71	The Cancer Genome Atlas	Thyroid Carcinoma	SLC25A10	0.06	0.03	blup	39	0.06	2.3e-06	6.3	7.0	3.2e-12	0.32	0.09	0.90	FALSE