Hub : Genes

TMC6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1150	0.0360	7.5e-04	0.002	0.004	0.009	0.019	0.016	1.5e-01	8.2e-02	2.4e-02	2.0e-03	3.8e-03
2	GTEx	Skin Sun Exposed Lower leg	0.1580	0.0500	2.7e-03	-0.002	NA	0.006	NA	0.010	5.3e-01	NA	9.8e-02	NA	4.4e-02
3	YFS	Blood	0.1422	0.0208	0.0e+00	0.045	0.082	0.098	0.083	0.092	1.9e-14	1.5e-25	2.4e-30	6.5e-26	1.4e-28
4	TCGA	Breast Invasive Carcinoma	0.0713	0.0263	2.7e-05	0.007	0.028	0.026	NA	0.016	1.2e-02	1.8e-06	4.0e-06	NA	2.2e-04
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.1076	0.0394	4.4e-05	0.023	0.038	0.031	NA	0.052	1.0e-03	3.9e-05	1.8e-04	NA	1.6e-06
6	TCGA	Prostate Adenocarcinoma	0.0778	0.0310	3.2e-04	0.038	0.028	0.036	NA	0.038	7.2e-05	6.1e-04	1.0e-04	NA	7.0e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.3	0.4	1.0	-1.0	0.6	0.5	-0.9	0.0	-0.4
Bipolar Disorder or Schizophrenia	0.4	1.1	4.5	-2.1	0.1	-0.8	-0.7	0.0	-0.8
Depressed Affect (Nagel 2018)	0.2	0.5	2.0	-1.4	-0.0	-0.5	0.6	0.2	0.3
Depression (Nagel 2018)	0.8	1.2	3.9	-2.0	-0.1	-1.3	-1.1	0.6	-0.4
Intelligence (Savage-Jansen 2018)	0.4	1.4	3.1	-1.7	-0.6	-0.4	-1.6	1.0	-1.0
Neuroticism (Nagel 2018)	0.3	0.7	3.9	-2.0	-0.5	-0.4	-0.0	0.1	0.2
Schizophrenia (2018)	0.5	1.0	3.3	-1.8	-0.7	-1.3	-0.2	0.0	-0.7
Schizophrenia vs Biploar Disorder	0.2	0.2	1.0	1.0	0.2	-0.0	0.3	0.0	-0.3
Worry (Nagel 2018)	0.6	1.2	3.2	-1.8	-1.8	0.8	0.1	0.2	-0.3
Alzheimer’s Disease (in mother)	0.2	0.2	0.8	0.1	-0.2	-0.0	0.9	0.3	0.5
Alzheimer’s Disease (in father)	0.9	1.0	3.3	-0.3	0.4	-0.9	0.1	1.2	1.8
Alzheimer’s Disease (including proxy)	0.6	0.9	3.7	0.1	-0.0	-0.2	1.0	0.7	1.9
Crohns Disease (2017)	0.8	1.8	3.5	-0.5	-1.4	0.4	1.8	-1.3	1.9
Irritable Bowel Disease (IBD)	0.6	1.4	3.8	-1.0	-0.1	-0.5	1.9	-0.3	2.0
Ulcerative Colitis (UC)	0.4	0.7	1.3	-0.7	0.9	-1.1	1.0	0.5	0.8
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	1.7	3.1	10.6	1.8	-0.1	3.2	2.0	-0.3	-0.9
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.4	-0.4	-0.1	-0.1	-0.6	1.2	0.1
Breast Cancer	0.8	1.9	5.6	0.4	0.6	-2.3	0.3	-2.4	-0.0
Ovarian Cancer	0.6	0.8	1.6	-0.7	-1.0	0.1	-1.1	-1.3	-0.8
Prostate Cancer	1.5	2.1	4.8	0.6	1.8	1.8	-0.2	-0.9	-2.2
Age at First Birth	0.5	0.7	2.6	-0.7	0.1	-0.1	-1.6	0.9	-0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.1	0.2	0.4	-0.6	0.4	-0.5	-0.4	0.0	0.3
Coronary Artery Disease (CAD)	0.6	0.7	3.6	-0.8	0.0	-1.9	-0.0	0.0	0.0
Crohns Disease (2012)	0.3	0.4	2.2	-0.3	-0.2	1.5	0.5	0.0	0.0
Mean Putamen Volume	1.0	1.1	4.9	0.5	0.3	0.9	-0.6	2.2	-0.7
Fasting Glucose	0.8	1.0	2.3	1.5	1.4	0.2	0.7	0.7	0.6
HbA1C	1.5	1.7	3.1	-1.8	0.3	1.8	-1.4	0.9	-1.0
HDL Cholesterol	0.4	0.7	3.3	-1.8	-0.2	-0.0	-0.8	0.0	-0.3
LDL Cholesterol	0.2	0.3	1.8	-0.1	1.4	0.1	0.4	0.0	-0.1
Lupus	0.6	0.9	2.3	-0.9	-0.6	-1.5	-0.8	-0.9	-0.3
Neuroticism (2016)	0.1	0.1	0.4	-0.4	-0.2	-0.4	0.3	-0.6	0.1
Primary Biliary Cirrhosis	0.2	0.4	1.1	-0.0	1.1	0.6	-0.1	0.0	-0.8
Rheumatoid Arthritis	0.6	0.8	2.1	-0.2	-0.9	-1.4	-0.6	0.0	1.2
Schizophrenia (2014)	0.4	0.8	2.6	-1.6	-0.4	-0.4	-0.8	0.0	-1.1
Triglycerides	1.2	1.9	4.7	2.2	1.6	1.6	1.2	0.0	0.3
Type 2 Diabetes (T2D) (2012)	0.7	0.8	4.0	0.1	0.3	-0.3	-0.6	0.0	-2.0
Ulcerative Colitis	0.4	0.6	1.5	-0.8	1.0	-1.2	0.7	0.0	0.0
Blood Eosinophil Count	0.3	2.5	6.1	2.5	-0.5	-1.8	1.4	0.6	1.7
Blood Platelet Count	0.9	10.0	32.3	1.3	-3.6	-2.0	1.8	-5.7	2.4
Blood Red Count	5.8	55.7	156.2	-4.4	3.1	3.9	-10.6	4.7	-12.5
Blood White Count	0.3	2.3	8.2	1.8	2.9	-0.5	1.4	-0.4	-0.1
Heel T-Score	0.4	3.4	8.1	2.8	-0.3	1.7	-0.0	2.9	1.3
BMI	0.3	1.8	5.1	2.3	1.4	0.8	1.2	-0.0	1.1
Height	0.2	4.8	9.2	2.3	1.6	2.3	2.5	-0.1	-3.0
Waist Hip Ratio (WHR)	0.4	1.6	4.9	0.9	0.6	1.9	0.1	0.1	-2.2
Systolic Blood Pressure	0.6	3.1	9.1	-0.7	-0.4	-1.7	-3.0	-0.9	-2.3
Smoking Status	0.7	1.6	3.4	1.1	0.6	0.9	1.8	-1.2	-1.6
Allergy or Eczema	1.0	2.5	4.4	-1.8	-2.1	-1.7	-1.7	1.0	1.0
Cardiovascular Disease	0.3	1.0	3.0	-0.3	-0.1	-0.9	-1.7	0.2	-1.5
Hypothyroidism (self reported)	0.6	1.4	4.9	1.0	1.3	2.2	0.6	-0.2	-0.6
Respiratory disease	0.4	0.9	2.5	1.0	-1.6	-1.0	-0.7	-0.5	-0.2
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.1	0.7	-1.1	-0.1	-0.4	-1.4	0.3
Lung FEV1/FVC ratio	0.1	0.6	1.9	0.6	1.4	1.2	0.2	-0.3	0.1
Lung FVC	0.7	3.5	10.0	-3.2	-0.4	-2.6	-1.7	1.0	0.3
Neuroticism	0.3	0.8	2.5	-1.6	-1.2	0.0	-0.2	-0.5	-0.7
Chronotype (morning person)	0.7	1.5	4.5	-0.6	-1.2	-0.3	0.6	1.5	2.1
Hair Pigment	0.0	1.2	3.5	1.0	0.9	0.8	-0.9	1.9	0.5
Tanning	0.0	0.3	1.3	0.0	0.2	-0.4	1.2	0.3	0.4
Hand grip strength (left)	0.7	1.8	4.5	-1.1	1.5	-1.4	-1.0	2.1	0.4
Number of treatments/medications taken	0.2	0.3	0.9	0.9	-0.3	0.4	-0.5	0.3	-0.5
Average weekly spirits intake	0.4	0.5	1.6	-0.1	-0.3	1.3	-0.3	-0.6	-0.8
Sensitivity / hurt feelings	0.3	0.6	1.7	-0.5	-0.2	1.3	0.1	1.1	-0.5
Frequency of depressed mood in last 2 weeks	1.1	1.6	5.3	-2.3	-0.9	-1.0	-1.4	0.5	-0.5
Hearing difficulty/problems: Yes	0.6	1.0	2.0	-0.2	0.8	-1.4	-0.2	-1.4	-1.1
Relative age of first facial hair	0.7	1.5	4.5	0.2	-0.9	2.1	-0.1	0.1	-1.9
Other serious medical condition/disability diagnosed by doctor	1.9	2.5	6.3	1.9	0.1	0.3	2.0	-2.5	0.8
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.5	0.2	1.9	1.3	-0.7	1.4	-1.1
Ever had hysterectomy (womb removed)	0.4	0.4	1.0	0.9	-0.4	0.4	-0.1	-1.0	-0.6
Systolic blood pressure, automated reading	0.4	1.3	4.8	0.3	0.5	-0.8	-2.2	-0.1	-1.4
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.0	-1.0	-0.3	-0.5	0.2	-0.9	0.5
Angina	0.5	0.7	1.5	-1.0	-0.1	-1.2	-1.1	-0.2	-0.8
Medication for hormone replacement therapy	0.3	0.4	0.9	0.6	0.9	0.3	0.0	-0.4	-0.9
Vitamin and mineral supplements	0.6	0.8	2.4	1.5	-0.3	0.6	0.9	-1.1	-0.2
Supplements: Zinc	0.2	0.2	0.6	-0.5	0.7	0.1	-0.8	0.1	-0.4
Medication: Co-codamol	0.6	0.7	2.4	0.0	-0.2	0.8	-0.4	1.6	-0.8
Medication: Metformin	0.4	0.6	1.3	1.1	-0.9	1.1	-0.3	-0.6	-0.4
Diabetes (father)	0.6	0.7	2.0	1.2	-0.1	0.5	0.5	0.6	1.4
Diabetes (mother)	0.3	0.4	0.8	0.4	-0.0	0.9	0.8	0.7	0.3
Severe depression (siblings)	1.0	1.2	5.0	0.3	0.5	1.2	0.5	2.2	0.2
Pack years adult smoking proportion	1.0	1.6	5.8	2.4	0.7	0.8	1.4	-0.6	0.1
Impedance of leg (right)	0.3	1.6	5.9	0.8	-0.4	1.5	2.4	-0.2	0.9
Leg fat-free mass (left)	0.1	0.7	2.2	0.8	1.5	-0.5	0.2	0.0	-0.8
Trunk fat percentage	1.0	3.9	10.1	3.2	1.9	2.0	2.2	-0.8	-0.2
Hand grip strength (right)	0.4	1.2	2.5	-1.2	1.0	-1.6	-1.1	0.9	0.3
Townsend deprivation index at recruitment	2.3	3.2	9.9	-0.5	-0.4	0.4	-0.9	-2.8	-3.1
Current tobacco smoking	0.3	0.5	1.5	-0.1	0.1	-0.3	0.1	-1.2	-1.0
Average weekly fortified wine intake	0.3	0.3	1.0	0.2	-0.5	-0.1	-0.6	-0.5	-1.0
Maternal smoking around birth	2.4	3.5	6.7	2.2	2.1	1.6	2.6	1.2	0.9
Fed-up feelings	0.2	0.4	1.8	-1.3	-0.6	-0.2	0.5	0.4	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.6	-0.6	0.1	-0.8	-0.4	-0.2	0.0
Relative age voice broke	0.2	0.3	1.4	0.0	-0.1	1.2	0.6	0.1	-0.2
Taking other prescription medications	0.4	0.6	2.2	0.7	0.3	1.5	0.9	-0.0	0.1
Age when periods started (menarche)	0.7	1.7	3.6	-1.7	-1.4	-1.0	-0.4	-1.9	-1.0
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.7	0.8	0.6	-0.2	0.3	0.5	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.8	6.9	2.3	0.5	2.6	1.7	1.4	0.1
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	2.2	-1.1	-0.4	-1.5	-0.4	-0.1	0.5
Qualifications: CSEs or equivalent	1.4	1.9	6.8	-0.4	-1.0	0.4	-0.2	-2.6	-1.8
Serious illness, injury or assault to yourself	1.5	1.9	5.3	1.9	0.5	0.5	2.3	-1.2	0.7
High blood pressure	0.4	1.1	3.3	0.1	0.9	-0.4	-1.5	0.4	-1.8
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.0	-0.7	-1.4	-0.8	-0.6	1.2	1.3
Multivitamins +/- minerals	0.9	1.2	2.7	-1.4	-0.2	-1.6	-1.4	-0.2	0.4
Stomach or abdominal pain in last month	0.6	0.8	1.8	-0.5	-1.0	-0.7	0.6	-1.3	0.7
Supplements: Glucosamine	0.8	1.1	2.8	-1.7	0.2	-0.9	-1.1	1.2	0.1
Diverticular disease/diverticulitis (self-reported)	1.4	1.6	3.2	1.5	1.5	1.8	1.0	-0.5	-0.9
Medication: Atenolol	1.8	2.2	6.7	-1.0	-1.2	-0.2	-2.6	0.3	-2.1
Medication: Levothyroxine sodium	1.5	2.5	7.9	1.6	1.3	2.8	-0.7	0.2	-1.6
Sitting height	0.1	0.4	1.1	0.0	0.5	-0.5	1.0	-0.3	-1.1
Chronic bronchitis/emphysema (father)	0.5	0.6	2.2	0.0	-0.4	0.2	-0.3	-1.5	-1.2
High blood pressure (mother)	0.5	0.8	1.5	-0.9	-0.5	-1.2	-0.8	-1.2	-0.0
Body mass index (BMI)	0.2	1.0	3.5	1.9	1.4	0.6	0.2	-0.1	-0.1
Impedance of leg (left)	0.3	1.5	4.1	1.0	-0.2	2.0	2.0	-0.2	0.3
Leg predicted mass (left)	0.1	0.6	2.0	0.8	1.4	-0.5	0.0	-0.1	-0.9
Trunk fat mass	0.9	3.7	10.4	3.2	2.1	1.7	1.8	-0.8	-0.7
Waist circumference	0.8	2.9	7.0	2.6	1.6	2.0	0.9	-0.5	-1.6
Number of incorrect matches in round	0.4	0.6	1.2	-0.7	-1.0	-0.2	-1.0	-0.2	-1.1
Past tobacco smoking	0.5	0.9	2.4	-0.1	0.6	-1.1	-1.6	1.0	0.7
Alcohol usually taken with meals	0.6	0.9	2.4	-0.5	0.2	-1.3	-1.6	-0.5	-0.9
Nervous feelings	0.3	0.6	1.7	-1.1	-1.3	0.1	-0.6	0.2	-0.5
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	6.0	-2.5	-1.6	-0.7	-0.1	-0.9	-0.3
Hearing difficulty/problems with background noise	0.2	0.4	0.9	0.2	0.9	-1.0	-0.1	-0.7	-0.2
Hair/balding pattern: Pattern 2	0.2	0.2	0.6	0.8	0.2	-0.1	0.6	-0.4	0.1
Had menopause	1.4	1.7	5.0	-0.8	1.4	-0.3	-1.5	0.5	-2.2
Had other major operations	0.7	0.9	1.6	1.2	1.2	1.0	1.2	0.2	-0.1
Forced vital capacity (FVC)	0.7	2.6	8.8	-2.4	-0.7	-3.0	-0.5	-0.4	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	3.8	1.4	0.4	1.9	0.9	-0.1	-0.7
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.2	-0.7	-0.2	-0.1	0.4	0.0	-1.1
Qualifications: None of the above	0.7	1.4	4.0	0.4	0.3	0.9	1.8	-2.0	-0.5
Financial difficulties in last 2 years	0.4	0.5	1.8	-1.4	-0.6	-0.3	-0.3	-0.4	-0.9
Mouth/teeth dental problems	1.0	1.5	3.4	1.0	0.1	0.4	1.5	1.5	1.8
Heart attack	0.6	0.8	2.0	1.4	0.9	0.7	0.5	1.2	-0.2
Allergy	0.3	0.7	1.4	0.2	1.2	1.1	0.9	-0.7	-0.2
Pain all over the body in last month	0.4	0.5	1.2	-0.2	0.3	1.1	-0.1	0.6	-1.1
Diabetes (self-reported)	0.4	0.6	1.8	1.4	-0.3	0.3	-0.5	-1.0	-0.7
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.5	0.1	-1.2	0.5	-0.8	0.2	-0.1
Medication: Ramipril	0.6	0.8	1.7	0.2	1.3	0.6	0.4	1.1	-1.1
Medication: Simvastatin	0.7	1.0	3.1	-0.5	0.0	-0.9	-1.2	-0.3	-1.8
Fluid intelligence score	0.7	1.4	3.2	1.3	1.0	0.5	1.4	1.8	0.7
Illnesses of siblings	0.4	0.5	1.2	-0.7	-0.8	-1.1	-0.1	-0.9	0.1
Neuroticism score	0.7	1.5	5.7	-2.4	-1.8	-0.2	-0.1	0.3	-0.2
Weight	0.4	1.9	5.2	2.3	1.9	0.9	0.8	-0.4	-1.0
Impedance of arm (right)	0.4	1.9	6.5	0.9	-0.8	1.3	2.6	-1.1	0.7
Arm fat percentage (right)	0.6	2.4	7.7	2.8	1.3	1.2	1.7	-0.7	0.4
Trunk fat-free mass	0.1	0.6	1.6	0.6	1.2	-0.4	-0.4	0.2	-1.3
Hip circumference	0.4	1.7	4.7	2.2	1.3	0.8	1.4	-1.0	-0.5
Time employed in main current job	2.5	2.9	6.3	-1.7	-2.5	-1.0	-2.2	-0.7	-1.4
Alcohol intake versus 10 years previously	0.5	0.8	3.6	0.3	-0.0	-0.5	-0.3	-1.9	-0.8
Father’s age at death	0.5	0.6	1.8	0.6	1.3	0.5	-0.8	0.5	-0.6
Worrier / anxious feelings	2.0	3.7	7.8	-2.8	-2.8	-1.9	-1.8	0.6	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.9	-1.4	-1.1	-0.1	0.6	-0.7	0.5
Falls in the last year	0.2	0.2	0.6	0.0	-0.4	-0.5	0.7	-0.1	0.5
Hair/balding pattern: Pattern 3	0.6	0.9	1.8	0.7	-1.1	0.8	0.2	1.1	1.4
Number of live births	2.2	3.2	7.4	2.6	1.1	1.7	2.7	0.9	0.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	4.8	-1.8	-0.5	-2.2	-0.5	-0.4	-0.1
Pulse rate	1.6	2.6	6.8	2.3	0.9	2.6	1.6	-0.2	0.4
Happiness	0.7	0.8	3.5	-1.9	-0.9	0.2	-0.5	-0.0	-0.7
Noisy workplace	4.7	5.8	19.0	-1.8	-2.9	-1.2	-1.0	-4.4	-1.5
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.4	0.4	-0.5	-0.3	-0.3	1.2	1.2
Serious illness, injury or assault of a close relative in last 2 years	2.2	2.5	4.0	1.4	1.3	2.0	1.9	1.8	0.9
Mouth/teeth dental problems: Dentures	0.4	0.6	2.2	-0.3	0.6	0.8	-0.6	-0.2	-1.5
Asthma	0.3	0.6	1.2	0.9	-0.7	-1.1	-1.0	-0.2	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.7	-1.6	0.2	-1.1	0.5	-1.0	0.9
Medication: Cholesterol lowering	0.3	0.5	1.4	1.2	-0.4	-0.8	0.5	-0.6	-0.0
Depression (self-reported)	0.4	0.5	0.9	-0.8	-0.3	-0.7	0.7	-0.9	0.5
Medication: Lansoprazole	0.8	0.9	2.3	1.2	-1.1	1.5	-0.1	-0.4	-0.4
Prospective memory result	1.5	1.9	3.9	-0.7	-1.9	-1.2	-1.2	-2.0	0.6
Lung cancer (father)	0.4	0.4	1.4	0.0	-0.6	0.5	-0.8	-1.2	-0.4
Illnesses of mother	0.7	0.9	3.3	1.1	0.1	0.5	0.1	1.8	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	2.6	-1.2	-0.5	-1.6	0.0	-0.4	0.0
Pulse wave Arterial Stiffness index	0.4	0.5	0.8	-0.5	0.5	0.9	-0.6	0.8	-0.7
Impedance of arm (left)	0.4	1.8	6.8	0.8	-0.7	1.4	2.6	-0.7	0.7
Arm fat mass (right)	0.6	2.5	7.6	2.8	1.9	1.2	1.4	-0.5	-0.2
Trunk predicted mass	0.1	0.7	1.9	0.6	1.1	-0.4	-0.5	0.2	-1.4
Standing height	0.2	1.9	5.4	1.3	1.5	0.8	1.2	-0.5	-2.3
Length of working week for main job	0.6	0.6	1.4	-1.1	-0.2	-1.2	-1.0	0.5	0.1
Exposure to tobacco smoke at home	0.9	1.1	2.3	1.2	1.0	1.1	1.5	-0.1	-0.6
Breastfed as a baby	1.2	1.5	3.7	-1.2	-1.3	-0.2	-1.5	-0.5	-1.9
Tense / ‘highly strung’	0.9	1.5	4.1	-2.0	-1.4	1.0	0.2	1.3	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.3	-0.2	0.7	0.8	0.1	-0.8
Hair/balding pattern: Pattern 4	0.4	1.1	3.1	-1.5	-0.3	-0.6	-0.6	-1.8	-0.4
Birth weight of first child	0.5	0.9	1.9	1.3	0.9	0.6	0.8	1.4	0.1
Peak expiratory flow (PEF)	0.3	0.8	3.1	-1.8	-0.9	-0.5	-0.3	-0.2	-0.6
Pulse wave reflection index	1.2	1.5	4.0	-1.8	-0.2	-2.0	-1.1	0.6	0.6
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.1	0.5	0.7	0.4	-0.4	1.5	-1.4
Loud music exposure frequency	1.7	1.9	3.5	1.5	1.9	1.5	1.6	0.8	-0.4
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	6.2	1.4	0.3	0.4	0.2	2.5	1.9
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.5	-1.2	0.2	-0.4	-1.0	-0.2	-1.6
Blood clot in the leg (DVT)	0.6	0.7	2.7	-0.5	-1.6	-0.4	0.6	-0.2	0.9
Medication: Paracetamol	0.3	0.6	0.9	-0.9	-0.9	-0.6	0.5	-0.8	0.8
Headache pain in last month	0.5	0.9	2.7	-1.6	-1.5	-0.7	0.0	-0.6	0.1
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	4.2	-2.0	0.1	0.6	-0.6	-0.0	-0.2
Glaucoma (self-reported)	0.6	0.7	1.4	-0.6	-1.2	0.4	-0.7	-1.1	-0.9
Gout (self-reported)	1.2	1.6	3.9	2.0	1.2	1.1	1.2	-1.0	-1.0
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	6.9	1.6	1.5	2.6	-0.0	-0.3	-2.0
Medication: Amlodipine	0.4	0.5	1.4	0.2	1.2	0.9	0.1	0.7	-0.5
Medication: Ventolin 100micrograms inhaler	0.5	0.7	2.5	-0.5	-1.6	-0.3	-0.4	-0.0	1.1
Birth weight	1.7	3.8	10.1	2.1	2.3	1.2	1.0	3.2	0.4
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.3	0.4	-1.0	0.5	1.0	-1.1	-0.4
High blood pressure (siblings)	0.5	0.7	1.7	0.2	1.3	0.1	-1.2	0.8	-0.5
Forced vital capacity (FVC), Best measure	0.5	1.7	6.0	-1.7	-0.8	-2.5	-0.3	-0.4	-0.4
Body fat percentage	1.0	3.9	10.4	3.2	2.0	2.1	2.1	-0.6	-0.1
Leg fat percentage (right)	0.4	1.4	4.5	2.1	0.9	1.2	1.1	-0.4	0.1
Arm fat-free mass (right)	0.2	0.8	2.5	0.8	1.6	-0.2	-0.3	0.3	-1.1
Exposure to tobacco smoke outside home	0.6	0.8	2.2	-1.5	0.5	-0.9	0.2	-1.1	-0.7
Comparative body size at age 10	0.9	2.6	5.2	-2.3	1.1	-2.3	-1.4	-1.4	-0.4
Number of full brothers	2.3	2.9	5.5	1.2	2.4	2.2	2.2	0.7	0.6
Worry too long after embarrassment	0.0	0.1	0.1	-0.3	0.3	-0.1	0.2	-0.4	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.2	0.6	-0.2	-0.8	1.5	-0.5	1.0
Wheeze or whistling in the chest in last year	0.4	0.7	1.4	1.2	0.3	-0.1	0.8	-1.0	-1.0
Number of children fathered	0.7	0.7	1.7	0.9	0.3	1.3	1.1	0.4	0.7
Reason for reducing amount of alcohol drunk: Health precaution	3.4	4.0	7.8	1.6	2.8	2.5	-0.2	2.4	-1.2
Age at first live birth	0.2	0.3	0.8	-0.4	0.0	0.7	-0.7	0.9	-0.1
Pulse wave peak to peak time	0.3	0.4	0.8	0.4	-0.6	-0.9	0.3	-0.9	0.2
Health satisfaction	0.1	0.2	0.7	0.2	0.0	-0.4	0.8	-0.5	-0.1
Shortness of breath walking on level ground	0.2	0.3	0.7	0.1	-0.8	-0.1	-0.0	-0.6	-0.8
Qualifications: College or University degree	0.2	0.5	1.9	-0.1	-0.3	-1.4	-0.5	-0.3	0.9
Eye problems/disorders: None of the above	0.5	0.6	2.1	-0.4	0.3	0.4	-0.6	1.5	-0.9
Mouth/teeth dental problems: Loose teeth	0.8	1.0	3.4	-0.7	-0.9	-1.1	-1.9	-0.2	-0.2
Emphysema/chronic bronchitis	0.3	0.3	0.8	0.8	-0.9	0.0	-0.4	-0.3	-0.5
Medication for pain relief, constipation, heartburn	0.5	0.8	3.8	0.7	0.2	0.4	-0.7	2.0	-0.1
Neck or shoulder pain in last month	0.2	0.3	1.0	-0.4	0.2	0.3	-0.4	-0.4	-1.0
Medication: Blood pressure	0.5	0.8	3.6	1.9	0.6	-0.1	0.7	0.7	0.1
Angina (self-reported)	0.7	0.9	2.1	-1.0	-0.1	-1.1	-1.5	-0.0	-1.1
Migraine (self-reported)	1.1	1.3	4.2	-0.5	-0.1	1.2	0.2	2.1	1.4
Medication: Ibuprofen	0.6	0.7	1.2	-1.1	1.1	-0.8	0.7	-0.5	0.8
Medication: Allopurinol	1.4	1.8	4.5	1.3	2.1	0.4	0.5	-1.3	-1.6
Medication: Omeprazole	0.5	0.6	1.8	0.4	1.2	0.5	1.3	0.1	0.3
Medication: Seretide 50 evohaler	0.5	0.6	1.5	0.8	0.8	0.2	-0.9	0.0	-1.2
Mean time to correctly identify matches	2.5	4.7	15.7	2.7	-0.5	4.0	1.7	-0.4	-1.5
Heart disease (mother)	2.3	2.8	5.5	-2.3	-0.1	-1.0	-2.0	-1.4	-2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.0	-1.0	-0.8	0.4	-0.5	-0.0	-0.7
Whole body fat mass	0.8	3.5	10.0	3.2	2.2	1.7	1.7	-0.5	-0.8
Leg fat mass (right)	0.5	2.1	6.2	2.5	1.7	1.1	1.2	-0.5	-0.6
Arm predicted mass (right)	0.1	0.7	2.5	0.8	1.6	-0.5	-0.2	0.2	-1.0
Pulse rate, automated reading	0.4	1.3	3.4	0.7	0.4	1.9	0.3	-1.6	-1.1
Alcohol intake frequency.	0.2	0.6	1.2	0.3	0.4	0.1	-1.1	0.9	1.1
Comparative height size at age 10	0.2	0.9	3.2	0.7	0.6	0.4	1.8	-0.5	-0.9
Number of full sisters	0.7	0.8	2.7	0.5	-1.7	0.6	0.6	-1.0	-0.4
Suffer from ‘nerves’	0.5	0.8	2.6	-0.5	-1.6	0.8	0.0	-0.7	-0.9
Overall health rating	0.2	0.4	1.0	0.0	-0.3	-0.4	1.0	-0.7	-0.8
Chest pain or discomfort	0.6	0.8	1.9	-0.4	-0.3	-1.0	-1.3	0.1	-1.4
Had major operations	0.5	0.6	2.2	-0.2	0.2	-0.6	-0.9	0.6	-1.5
Age at last live birth	0.2	0.3	1.2	-0.0	0.5	-0.2	0.3	1.1	0.3
Family relationship satisfaction	0.4	0.5	2.3	-0.3	-1.5	0.0	-0.2	-0.3	-0.8
Leg pain on walking	0.3	0.4	1.8	-0.3	0.3	0.0	0.1	1.4	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.0	-0.1	0.1	0.7	-1.0	1.4	-1.3
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.5	0.5	0.6	-0.2	1.0	1.2	1.0
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	3.4	-0.3	0.2	-0.4	-1.8	0.1	-0.6
Medication: Aspirin	0.9	1.2	2.3	-1.1	0.6	-0.8	-1.2	-1.5	-1.2
Supplements: Vitamin C	2.5	3.0	8.0	0.7	1.9	1.2	1.5	2.8	1.5
Knee pain experienced in last month	0.4	0.6	1.9	-1.0	-0.4	-0.9	-1.4	-0.0	-0.0
Hypertension (Self-reported)	0.4	1.2	4.1	0.0	1.1	-0.5	-1.4	0.1	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.7	0.9	0.5	0.4	0.4	-0.4	-0.7
Illnesses of father: Heart disease	1.4	1.9	5.2	-0.9	0.5	-1.5	-2.3	-1.0	-1.5
Illnesses of siblings: Diabetes	1.3	1.6	2.5	1.5	-1.4	1.5	1.6	-0.2	1.0
Smoking status: Previous	0.7	1.1	3.3	0.5	0.2	1.4	1.8	-0.5	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	2.1	-0.2	-1.4	-0.2	0.7	-0.2	-1.2
Whole body fat-free mass	0.1	0.7	1.8	0.7	1.3	-0.4	-0.2	0.0	-1.2
Leg fat-free mass (right)	0.1	0.7	2.2	0.7	1.5	-0.4	-0.2	-0.0	-1.2
Arm fat percentage (left)	0.6	2.3	7.0	2.6	1.4	1.2	1.6	-0.5	0.4
Average weekly red wine intake	0.3	0.5	1.0	0.7	-0.8	-0.3	0.7	0.6	1.0
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.5	-0.6	-1.2	-0.7	-0.5	-0.6	-1.1
Mood swings	0.7	1.2	5.8	-2.4	0.3	-0.3	0.4	0.2	1.1
Loneliness, isolation	0.5	0.7	2.7	-1.6	0.1	-0.7	-0.1	-0.9	0.4
Long-standing illness, disability or infirmity	0.4	0.7	1.1	1.1	-1.0	0.3	-0.2	-1.0	-0.8
Ever had bowel cancer screening	0.8	1.0	2.5	0.3	0.5	1.6	0.0	1.0	-1.4
Diabetes diagnosed by doctor	0.4	0.6	1.9	0.9	-0.9	0.4	-0.2	-1.4	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	3.4	3.7	6.1	2.4	1.9	2.5	1.8	0.7	-1.7
Friendships satisfaction	0.6	0.8	3.1	-1.1	-1.8	-0.7	-0.1	-0.3	-0.0
Qualifications: nursing, teaching	0.5	0.8	1.5	0.1	-1.2	-1.2	-0.8	-0.0	1.1
Commuting to job workplace: Walk	0.6	0.7	1.6	0.9	0.6	-0.1	1.3	-1.0	0.4
Eye problems/disorders: Cataract	0.3	0.3	1.1	0.3	0.1	0.4	0.7	-1.1	0.1
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	2.0	-1.2	-1.2	0.1	0.8	-1.4	1.1
Medication for cholesterol	0.5	0.8	2.2	0.6	-0.4	-0.9	0.8	-0.7	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.1	0.1	1.0	0.7	-0.4	-0.6	-1.4
Back pain experienced in last month	0.3	0.4	1.0	-1.0	-0.8	-0.4	0.0	-0.9	-0.0
Mineral and other dietary supplements	1.7	2.3	6.2	2.5	1.5	1.5	1.7	-0.4	-0.6
Breast cancer (self-reported)	0.4	0.5	2.5	0.3	1.6	-0.3	0.5	-0.5	0.0
Asthma (self-reported)	0.3	0.7	1.4	0.6	-1.1	-1.0	-1.2	0.0	-0.4
Osteoporosis (self-reported)	0.1	0.1	0.2	0.3	0.5	-0.2	-0.3	0.1	-0.2
Osteoarthritis (self-reported)	0.2	0.3	1.1	-0.3	0.2	0.4	-0.4	-0.5	-1.1
Medication: Aspirin	0.6	0.7	1.8	-0.9	0.6	-0.4	-0.6	-1.3	-0.9
Medication: Gliclazide	0.6	0.7	1.3	1.1	-1.2	-0.5	0.4	0.3	1.1
Illnesses of father: None of the above (group 1)	0.8	1.0	2.0	0.0	-0.5	1.0	1.1	1.4	1.4
Smoking status: Current	0.2	0.4	1.1	-0.1	0.2	-0.2	0.0	-1.0	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	4.4	-2.0	-0.8	-2.1	-1.5	1.0	-0.3
Whole body water mass	0.1	0.6	1.8	0.7	1.3	-0.5	-0.2	0.1	-1.1
Leg predicted mass (right)	0.1	0.7	2.2	0.7	1.5	-0.3	-0.2	-0.0	-1.2
Arm fat mass (left)	0.5	2.2	6.9	2.6	1.9	1.1	1.1	-0.4	-0.3
Number of self-reported non-cancer illnesses	0.6	1.0	4.0	1.0	0.3	0.1	-0.8	0.4	-2.0
Average weekly champagne plus white wine intake	0.9	1.2	4.0	-0.3	1.7	0.3	-0.2	2.0	0.3
Miserableness	0.6	1.1	2.8	-1.3	-1.7	-1.2	0.2	-0.8	0.3
Guilty feelings	1.3	2.0	6.0	-2.5	-1.1	-1.7	-1.0	-0.9	0.2
Wears glasses or contact lenses	0.8	0.9	3.0	1.7	1.1	0.4	-0.1	-0.5	-0.9
Ever taken oral contraceptive pill	0.7	0.7	1.8	-1.2	-0.9	1.4	0.5	-0.3	-0.1
Hearing aid user	1.9	2.2	5.9	1.7	2.4	1.0	1.8	-0.3	-0.5
Mother’s age at death	0.4	0.5	2.5	-0.3	0.1	1.6	0.5	0.4	-0.3
Financial situation satisfaction	0.6	0.7	3.3	-1.8	0.2	-0.1	-0.5	-0.5	-0.8
Tinnitus: Yes, now most or all of the time	0.7	0.8	3.3	-0.2	1.8	0.8	0.8	-0.1	0.2
Commuting to job workplace: Public transport	0.2	0.3	0.9	-0.0	0.2	0.9	-0.7	0.5	0.3
Eye problems/disorders: Glaucoma	0.3	0.3	1.7	0.1	0.4	-0.1	-0.2	-1.3	-0.2
Medication: Blood pressure	0.7	1.3	3.1	-1.2	0.3	0.7	-1.6	0.6	-1.8
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.3	-0.3	-0.4	1.5	0.3	-1.0	-1.3
Supplements: Fish oil (including cod liver oil)	1.7	2.3	4.3	-2.1	-0.7	-1.7	-2.0	1.0	0.9
High cholesterol (Self-reported)	0.2	0.3	1.4	-0.2	-1.2	-0.3	0.2	0.3	-0.7
Medication: Bendroflumethiazide	1.6	2.5	5.4	-0.9	-1.1	1.5	-2.3	0.5	-2.3
Medication: Paracetamol	0.2	0.3	0.7	-0.3	-0.6	-0.0	0.6	-0.3	0.8
Medication: Lisinopril	0.6	0.8	1.9	1.2	1.4	-0.1	0.9	0.3	0.8
Medication: Atorvastatin	0.6	0.8	1.6	1.2	-1.0	0.5	1.0	0.5	0.9
Illnesses of father: High blood pressure	0.6	0.7	2.5	-0.2	1.2	-0.0	-0.4	1.6	0.4
Alcohol drinker status: Never	0.9	1.1	2.7	-0.0	-0.3	0.2	-1.4	1.6	-1.2
Ever smoked	0.4	0.8	1.5	0.6	-0.9	1.0	1.2	-0.8	-0.6
Basal metabolic rate	0.1	0.8	2.4	1.1	1.6	-0.0	0.2	0.1	-1.0
Leg fat percentage (left)	0.5	1.6	5.4	2.3	1.1	1.6	0.8	-0.2	-0.2
Arm fat-free mass (left)	0.2	0.8	2.1	1.1	1.5	-0.0	-0.1	0.1	-1.1
Number of operations (self-reported)	3.0	4.5	9.3	2.5	3.0	2.2	1.4	1.4	-1.6
Average weekly beer plus cider intake	0.8	1.2	3.9	0.4	0.7	1.1	0.3	-2.0	-1.2
Irritability	0.6	1.0	3.1	-1.8	-0.2	0.9	-0.2	1.1	0.9
Risk taking	1.2	1.8	4.8	-0.3	-0.8	-2.2	1.0	-1.1	1.7
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.5	-0.0	0.9	0.7	0.1	1.6	0.8
Fractured/broken bones in last 5 years	2.0	2.6	5.4	1.4	2.3	2.2	1.0	-0.6	-1.4
Age started oral contraceptive pill	1.4	1.7	4.0	0.0	2.0	1.4	0.2	2.0	0.3
Diastolic blood pressure, automated reading	0.5	1.6	5.0	-0.3	1.0	-0.5	-2.2	0.3	-1.7
Ever depressed for a whole week	0.2	0.3	0.8	-0.3	0.9	0.0	0.3	0.9	-0.1
Unable to work because of sickness or disability	0.9	1.2	3.9	2.0	0.0	0.0	0.9	-1.6	0.0
Commuting to job workplace: Cycle	0.5	0.6	1.6	0.3	0.9	0.9	0.0	1.3	-0.3
Myopia	1.3	1.9	3.9	1.7	1.6	1.4	-0.4	0.3	-2.0
Vascular/heart problems diagnosed by doctor	0.6	1.6	4.8	-0.1	-0.9	0.8	1.8	-0.4	2.2
Cholesterol lowering medication	0.4	0.6	2.0	-1.4	-0.7	-0.0	-0.3	1.1	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	1.0	-0.5	0.4	-0.3	1.0	-0.0	0.4
Pain experienced in last month	0.3	0.4	1.1	-0.3	0.0	-0.8	-1.0	-0.8	-0.5
Supplements: Calcium	0.1	0.1	0.3	-0.1	0.1	0.4	0.4	0.3	0.6
Basal cell carcinoma (self-reported)	0.6	0.7	1.2	-0.9	1.1	1.1	-0.3	0.9	-0.3
Heart attack/myocardial infarction (self-reported)	0.7	0.8	2.1	1.2	0.9	0.7	0.3	1.4	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.3	-0.3	-1.5	-0.3	0.7	-0.3	0.8
Heart disease (siblings)	0.2	0.2	0.9	-0.2	0.0	-0.6	-0.9	0.3	0.3
Alcohol drinker status: Previous	0.8	1.0	3.5	0.1	-0.1	0.4	1.2	0.8	1.9
Pack years of smoking	1.2	1.7	7.0	2.6	0.5	1.1	1.2	-0.6	-0.2
Impedance of whole body	0.3	1.7	5.8	1.1	-0.7	1.5	2.4	-0.6	0.5
Leg fat mass (left)	0.6	2.2	6.6	2.6	1.8	1.3	0.9	-0.3	-0.8
Arm predicted mass (left)	0.1	0.7	2.0	1.0	1.4	-0.3	-0.0	-0.0	-1.1