TWAS hub - TMC6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1150	0.0360	7.5e-04	0.002	0.004	0.009	0.019	0.016	1.5e-01	8.2e-02	2.4e-02	2.0e-03	3.8e-03
2	GTEx	Skin Sun Exposed Lower leg	0.1580	0.0500	2.7e-03	-0.002	NA	0.006	NA	0.010	5.3e-01	NA	9.8e-02	NA	4.4e-02
3	YFS	Blood	0.1422	0.0208	0.0e+00	0.045	0.082	0.098	0.083	0.092	1.9e-14	1.5e-25	2.4e-30	6.5e-26	1.4e-28
4	TCGA	Breast Invasive Carcinoma	0.0713	0.0263	2.7e-05	0.007	0.028	0.026	NA	0.016	1.2e-02	1.8e-06	4.0e-06	NA	2.2e-04
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.1076	0.0394	4.4e-05	0.023	0.038	0.031	NA	0.052	1.0e-03	3.9e-05	1.8e-04	NA	1.6e-06
6	TCGA	Prostate Adenocarcinoma	0.0778	0.0310	3.2e-04	0.038	0.028	0.036	NA	0.038	7.2e-05	6.1e-04	1.0e-04	NA	7.0e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Blood Red Count	5.8	55.7	156.2	-4.4	3.1	3.9	-10.6	4.7	-12.5
Noisy workplace	4.7	5.8	19.0	-1.8	-2.9	-1.2	-1.0	-4.4	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	3.4	4.0	7.8	1.6	2.8	2.5	-0.2	2.4	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	3.4	3.7	6.1	2.4	1.9	2.5	1.8	0.7	-1.7
Number of operations (self-reported)	3.0	4.5	9.3	2.5	3.0	2.2	1.4	1.4	-1.6
Time employed in main current job	2.5	2.9	6.3	-1.7	-2.5	-1.0	-2.2	-0.7	-1.4
Mean time to correctly identify matches	2.5	4.7	15.7	2.7	-0.5	4.0	1.7	-0.4	-1.5
Supplements: Vitamin C	2.5	3.0	8.0	0.7	1.9	1.2	1.5	2.8	1.5
Maternal smoking around birth	2.4	3.5	6.7	2.2	2.1	1.6	2.6	1.2	0.9
Townsend deprivation index at recruitment	2.3	3.2	9.9	-0.5	-0.4	0.4	-0.9	-2.8	-3.1
Number of full brothers	2.3	2.9	5.5	1.2	2.4	2.2	2.2	0.7	0.6
Heart disease (mother)	2.3	2.8	5.5	-2.3	-0.1	-1.0	-2.0	-1.4	-2.1
Number of live births	2.2	3.2	7.4	2.6	1.1	1.7	2.7	0.9	0.1
Serious illness, injury or assault of a close relative in last 2 years	2.2	2.5	4.0	1.4	1.3	2.0	1.9	1.8	0.9
Worrier / anxious feelings	2.0	3.7	7.8	-2.8	-2.8	-1.9	-1.8	0.6	0.0
Fractured/broken bones in last 5 years	2.0	2.6	5.4	1.4	2.3	2.2	1.0	-0.6	-1.4
Other serious medical condition/disability diagnosed by doctor	1.9	2.5	6.3	1.9	0.1	0.3	2.0	-2.5	0.8
Hearing aid user	1.9	2.2	5.9	1.7	2.4	1.0	1.8	-0.3	-0.5
Medication: Atenolol	1.8	2.2	6.7	-1.0	-1.2	-0.2	-2.6	0.3	-2.1
Reaction Time	1.7	3.1	10.6	1.8	-0.1	3.2	2.0	-0.3	-0.9
Loud music exposure frequency	1.7	1.9	3.5	1.5	1.9	1.5	1.6	0.8	-0.4
Birth weight	1.7	3.8	10.1	2.1	2.3	1.2	1.0	3.2	0.4
Mineral and other dietary supplements	1.7	2.3	6.2	2.5	1.5	1.5	1.7	-0.4	-0.6
Supplements: Fish oil (including cod liver oil)	1.7	2.3	4.3	-2.1	-0.7	-1.7	-2.0	1.0	0.9
Pulse rate	1.6	2.6	6.8	2.3	0.9	2.6	1.6	-0.2	0.4
Medication: Bendroflumethiazide	1.6	2.5	5.4	-0.9	-1.1	1.5	-2.3	0.5	-2.3
Prostate Cancer	1.5	2.1	4.8	0.6	1.8	1.8	-0.2	-0.9	-2.2
HbA1C	1.5	1.7	3.1	-1.8	0.3	1.8	-1.4	0.9	-1.0
Serious illness, injury or assault to yourself	1.5	1.9	5.3	1.9	0.5	0.5	2.3	-1.2	0.7
Medication: Levothyroxine sodium	1.5	2.5	7.9	1.6	1.3	2.8	-0.7	0.2	-1.6
Prospective memory result	1.5	1.9	3.9	-0.7	-1.9	-1.2	-1.2	-2.0	0.6
Qualifications: CSEs or equivalent	1.4	1.9	6.8	-0.4	-1.0	0.4	-0.2	-2.6	-1.8
Diverticular disease/diverticulitis (self-reported)	1.4	1.6	3.2	1.5	1.5	1.8	1.0	-0.5	-0.9
Had menopause	1.4	1.7	5.0	-0.8	1.4	-0.3	-1.5	0.5	-2.2
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	6.9	1.6	1.5	2.6	-0.0	-0.3	-2.0
Medication: Allopurinol	1.4	1.8	4.5	1.3	2.1	0.4	0.5	-1.3	-1.6
Illnesses of father: Heart disease	1.4	1.9	5.2	-0.9	0.5	-1.5	-2.3	-1.0	-1.5
Age started oral contraceptive pill	1.4	1.7	4.0	0.0	2.0	1.4	0.2	2.0	0.3
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.8	6.9	2.3	0.5	2.6	1.7	1.4	0.1
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	6.2	1.4	0.3	0.4	0.2	2.5	1.9
Illnesses of siblings: Diabetes	1.3	1.6	2.5	1.5	-1.4	1.5	1.6	-0.2	1.0
Guilty feelings	1.3	2.0	6.0	-2.5	-1.1	-1.7	-1.0	-0.9	0.2
Myopia	1.3	1.9	3.9	1.7	1.6	1.4	-0.4	0.3	-2.0
Triglycerides	1.2	1.9	4.7	2.2	1.6	1.6	1.2	0.0	0.3
Breastfed as a baby	1.2	1.5	3.7	-1.2	-1.3	-0.2	-1.5	-0.5	-1.9
Pulse wave reflection index	1.2	1.5	4.0	-1.8	-0.2	-2.0	-1.1	0.6	0.6
Gout (self-reported)	1.2	1.6	3.9	2.0	1.2	1.1	1.2	-1.0	-1.0
Risk taking	1.2	1.8	4.8	-0.3	-0.8	-2.2	1.0	-1.1	1.7
Pack years of smoking	1.2	1.7	7.0	2.6	0.5	1.1	1.2	-0.6	-0.2
Frequency of depressed mood in last 2 weeks	1.1	1.6	5.3	-2.3	-0.9	-1.0	-1.4	0.5	-0.5
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.5	0.2	1.9	1.3	-0.7	1.4	-1.1
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	6.0	-2.5	-1.6	-0.7	-0.1	-0.9	-0.3
Migraine (self-reported)	1.1	1.3	4.2	-0.5	-0.1	1.2	0.2	2.1	1.4
Mean Putamen Volume	1.0	1.1	4.9	0.5	0.3	0.9	-0.6	2.2	-0.7
Allergy or Eczema	1.0	2.5	4.4	-1.8	-2.1	-1.7	-1.7	1.0	1.0
Severe depression (siblings)	1.0	1.2	5.0	0.3	0.5	1.2	0.5	2.2	0.2
Pack years adult smoking proportion	1.0	1.6	5.8	2.4	0.7	0.8	1.4	-0.6	0.1
Trunk fat percentage	1.0	3.9	10.1	3.2	1.9	2.0	2.2	-0.8	-0.2
Mouth/teeth dental problems	1.0	1.5	3.4	1.0	0.1	0.4	1.5	1.5	1.8
Body fat percentage	1.0	3.9	10.4	3.2	2.0	2.1	2.1	-0.6	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	4.4	-2.0	-0.8	-2.1	-1.5	1.0	-0.3
Alzheimer’s Disease (in father)	0.9	1.0	3.3	-0.3	0.4	-0.9	0.1	1.2	1.8
Blood Platelet Count	0.9	10.0	32.3	1.3	-3.6	-2.0	1.8	-5.7	2.4
Multivitamins +/- minerals	0.9	1.2	2.7	-1.4	-0.2	-1.6	-1.4	-0.2	0.4
Trunk fat mass	0.9	3.7	10.4	3.2	2.1	1.7	1.8	-0.8	-0.7
Exposure to tobacco smoke at home	0.9	1.1	2.3	1.2	1.0	1.1	1.5	-0.1	-0.6
Tense / ‘highly strung’	0.9	1.5	4.1	-2.0	-1.4	1.0	0.2	1.3	-0.2
Comparative body size at age 10	0.9	2.6	5.2	-2.3	1.1	-2.3	-1.4	-1.4	-0.4
Medication: Aspirin	0.9	1.2	2.3	-1.1	0.6	-0.8	-1.2	-1.5	-1.2
Average weekly champagne plus white wine intake	0.9	1.2	4.0	-0.3	1.7	0.3	-0.2	2.0	0.3
Alcohol drinker status: Never	0.9	1.1	2.7	-0.0	-0.3	0.2	-1.4	1.6	-1.2
Unable to work because of sickness or disability	0.9	1.2	3.9	2.0	0.0	0.0	0.9	-1.6	0.0
Depression (Nagel 2018)	0.8	1.2	3.9	-2.0	-0.1	-1.3	-1.1	0.6	-0.4
Crohns Disease (2017)	0.8	1.8	3.5	-0.5	-1.4	0.4	1.8	-1.3	1.9
Breast Cancer	0.8	1.9	5.6	0.4	0.6	-2.3	0.3	-2.4	-0.0
Fasting Glucose	0.8	1.0	2.3	1.5	1.4	0.2	0.7	0.7	0.6
Supplements: Glucosamine	0.8	1.1	2.8	-1.7	0.2	-0.9	-1.1	1.2	0.1
Waist circumference	0.8	2.9	7.0	2.6	1.6	2.0	0.9	-0.5	-1.6
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.7	-1.6	0.2	-1.1	0.5	-1.0	0.9
Medication: Lansoprazole	0.8	0.9	2.3	1.2	-1.1	1.5	-0.1	-0.4	-0.4
Mouth/teeth dental problems: Loose teeth	0.8	1.0	3.4	-0.7	-0.9	-1.1	-1.9	-0.2	-0.2
Whole body fat mass	0.8	3.5	10.0	3.2	2.2	1.7	1.7	-0.5	-0.8
Ever had bowel cancer screening	0.8	1.0	2.5	0.3	0.5	1.6	0.0	1.0	-1.4
Illnesses of father: None of the above (group 1)	0.8	1.0	2.0	0.0	-0.5	1.0	1.1	1.4	1.4
Wears glasses or contact lenses	0.8	0.9	3.0	1.7	1.1	0.4	-0.1	-0.5	-0.9
Average weekly beer plus cider intake	0.8	1.2	3.9	0.4	0.7	1.1	0.3	-2.0	-1.2
Alcohol drinker status: Previous	0.8	1.0	3.5	0.1	-0.1	0.4	1.2	0.8	1.9
Type 2 Diabetes (T2D) (2012)	0.7	0.8	4.0	0.1	0.3	-0.3	-0.6	0.0	-2.0
Smoking Status	0.7	1.6	3.4	1.1	0.6	0.9	1.8	-1.2	-1.6
Lung FVC	0.7	3.5	10.0	-3.2	-0.4	-2.6	-1.7	1.0	0.3
Chronotype (morning person)	0.7	1.5	4.5	-0.6	-1.2	-0.3	0.6	1.5	2.1
Hand grip strength (left)	0.7	1.8	4.5	-1.1	1.5	-1.4	-1.0	2.1	0.4
Relative age of first facial hair	0.7	1.5	4.5	0.2	-0.9	2.1	-0.1	0.1	-1.9
Age when periods started (menarche)	0.7	1.7	3.6	-1.7	-1.4	-1.0	-0.4	-1.9	-1.0
Had other major operations	0.7	0.9	1.6	1.2	1.2	1.0	1.2	0.2	-0.1
Forced vital capacity (FVC)	0.7	2.6	8.8	-2.4	-0.7	-3.0	-0.5	-0.4	-0.6
Qualifications: None of the above	0.7	1.4	4.0	0.4	0.3	0.9	1.8	-2.0	-0.5
Medication: Simvastatin	0.7	1.0	3.1	-0.5	0.0	-0.9	-1.2	-0.3	-1.8
Fluid intelligence score	0.7	1.4	3.2	1.3	1.0	0.5	1.4	1.8	0.7
Neuroticism score	0.7	1.5	5.7	-2.4	-1.8	-0.2	-0.1	0.3	-0.2
Happiness	0.7	0.8	3.5	-1.9	-0.9	0.2	-0.5	-0.0	-0.7
Illnesses of mother	0.7	0.9	3.3	1.1	0.1	0.5	0.1	1.8	0.6
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.1	0.5	0.7	0.4	-0.4	1.5	-1.4
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.5	-1.2	0.2	-0.4	-1.0	-0.2	-1.6
Number of children fathered	0.7	0.7	1.7	0.9	0.3	1.3	1.1	0.4	0.7
Angina (self-reported)	0.7	0.9	2.1	-1.0	-0.1	-1.1	-1.5	-0.0	-1.1
Number of full sisters	0.7	0.8	2.7	0.5	-1.7	0.6	0.6	-1.0	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.0	-0.1	0.1	0.7	-1.0	1.4	-1.3
Smoking status: Previous	0.7	1.1	3.3	0.5	0.2	1.4	1.8	-0.5	-0.7
Mood swings	0.7	1.2	5.8	-2.4	0.3	-0.3	0.4	0.2	1.1
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	2.0	-1.2	-1.2	0.1	0.8	-1.4	1.1
Ever taken oral contraceptive pill	0.7	0.7	1.8	-1.2	-0.9	1.4	0.5	-0.3	-0.1
Tinnitus: Yes, now most or all of the time	0.7	0.8	3.3	-0.2	1.8	0.8	0.8	-0.1	0.2
Medication: Blood pressure	0.7	1.3	3.1	-1.2	0.3	0.7	-1.6	0.6	-1.8
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.3	-0.3	-0.4	1.5	0.3	-1.0	-1.3
Heart attack/myocardial infarction (self-reported)	0.7	0.8	2.1	1.2	0.9	0.7	0.3	1.4	-0.3
Worry (Nagel 2018)	0.6	1.2	3.2	-1.8	-1.8	0.8	0.1	0.2	-0.3
Alzheimer’s Disease (including proxy)	0.6	0.9	3.7	0.1	-0.0	-0.2	1.0	0.7	1.9
Irritable Bowel Disease (IBD)	0.6	1.4	3.8	-1.0	-0.1	-0.5	1.9	-0.3	2.0
Ovarian Cancer	0.6	0.8	1.6	-0.7	-1.0	0.1	-1.1	-1.3	-0.8
Coronary Artery Disease (CAD)	0.6	0.7	3.6	-0.8	0.0	-1.9	-0.0	0.0	0.0
Lupus	0.6	0.9	2.3	-0.9	-0.6	-1.5	-0.8	-0.9	-0.3
Rheumatoid Arthritis	0.6	0.8	2.1	-0.2	-0.9	-1.4	-0.6	0.0	1.2
Systolic Blood Pressure	0.6	3.1	9.1	-0.7	-0.4	-1.7	-3.0	-0.9	-2.3
Hypothyroidism (self reported)	0.6	1.4	4.9	1.0	1.3	2.2	0.6	-0.2	-0.6
Hearing difficulty/problems: Yes	0.6	1.0	2.0	-0.2	0.8	-1.4	-0.2	-1.4	-1.1
Vitamin and mineral supplements	0.6	0.8	2.4	1.5	-0.3	0.6	0.9	-1.1	-0.2
Medication: Co-codamol	0.6	0.7	2.4	0.0	-0.2	0.8	-0.4	1.6	-0.8
Diabetes (father)	0.6	0.7	2.0	1.2	-0.1	0.5	0.5	0.6	1.4
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	2.2	-1.1	-0.4	-1.5	-0.4	-0.1	0.5
Stomach or abdominal pain in last month	0.6	0.8	1.8	-0.5	-1.0	-0.7	0.6	-1.3	0.7
Alcohol usually taken with meals	0.6	0.9	2.4	-0.5	0.2	-1.3	-1.6	-0.5	-0.9
Heart attack	0.6	0.8	2.0	1.4	0.9	0.7	0.5	1.2	-0.2
Medication: Ramipril	0.6	0.8	1.7	0.2	1.3	0.6	0.4	1.1	-1.1
Arm fat percentage (right)	0.6	2.4	7.7	2.8	1.3	1.2	1.7	-0.7	0.4
Hair/balding pattern: Pattern 3	0.6	0.9	1.8	0.7	-1.1	0.8	0.2	1.1	1.4
Arm fat mass (right)	0.6	2.5	7.6	2.8	1.9	1.2	1.4	-0.5	-0.2
Length of working week for main job	0.6	0.6	1.4	-1.1	-0.2	-1.2	-1.0	0.5	0.1
Blood clot in the leg (DVT)	0.6	0.7	2.7	-0.5	-1.6	-0.4	0.6	-0.2	0.9
Glaucoma (self-reported)	0.6	0.7	1.4	-0.6	-1.2	0.4	-0.7	-1.1	-0.9
Exposure to tobacco smoke outside home	0.6	0.8	2.2	-1.5	0.5	-0.9	0.2	-1.1	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.2	0.6	-0.2	-0.8	1.5	-0.5	1.0
Medication: Ibuprofen	0.6	0.7	1.2	-1.1	1.1	-0.8	0.7	-0.5	0.8
Chest pain or discomfort	0.6	0.8	1.9	-0.4	-0.3	-1.0	-1.3	0.1	-1.4
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.5	0.5	0.6	-0.2	1.0	1.2	1.0
Arm fat percentage (left)	0.6	2.3	7.0	2.6	1.4	1.2	1.6	-0.5	0.4
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.5	-0.6	-1.2	-0.7	-0.5	-0.6	-1.1
Friendships satisfaction	0.6	0.8	3.1	-1.1	-1.8	-0.7	-0.1	-0.3	-0.0
Commuting to job workplace: Walk	0.6	0.7	1.6	0.9	0.6	-0.1	1.3	-1.0	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.1	0.1	1.0	0.7	-0.4	-0.6	-1.4
Medication: Aspirin	0.6	0.7	1.8	-0.9	0.6	-0.4	-0.6	-1.3	-0.9
Medication: Gliclazide	0.6	0.7	1.3	1.1	-1.2	-0.5	0.4	0.3	1.1
Number of self-reported non-cancer illnesses	0.6	1.0	4.0	1.0	0.3	0.1	-0.8	0.4	-2.0
Miserableness	0.6	1.1	2.8	-1.3	-1.7	-1.2	0.2	-0.8	0.3
Financial situation satisfaction	0.6	0.7	3.3	-1.8	0.2	-0.1	-0.5	-0.5	-0.8
Medication: Lisinopril	0.6	0.8	1.9	1.2	1.4	-0.1	0.9	0.3	0.8
Medication: Atorvastatin	0.6	0.8	1.6	1.2	-1.0	0.5	1.0	0.5	0.9
Illnesses of father: High blood pressure	0.6	0.7	2.5	-0.2	1.2	-0.0	-0.4	1.6	0.4
Irritability	0.6	1.0	3.1	-1.8	-0.2	0.9	-0.2	1.1	0.9
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.5	-0.0	0.9	0.7	0.1	1.6	0.8
Vascular/heart problems diagnosed by doctor	0.6	1.6	4.8	-0.1	-0.9	0.8	1.8	-0.4	2.2
Basal cell carcinoma (self-reported)	0.6	0.7	1.2	-0.9	1.1	1.1	-0.3	0.9	-0.3
Leg fat mass (left)	0.6	2.2	6.6	2.6	1.8	1.3	0.9	-0.3	-0.8
Schizophrenia (2018)	0.5	1.0	3.3	-1.8	-0.7	-1.3	-0.2	0.0	-0.7
Age at First Birth	0.5	0.7	2.6	-0.7	0.1	-0.1	-1.6	0.9	-0.6
Angina	0.5	0.7	1.5	-1.0	-0.1	-1.2	-1.1	-0.2	-0.8
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.0	-0.7	-1.4	-0.8	-0.6	1.2	1.3
Chronic bronchitis/emphysema (father)	0.5	0.6	2.2	0.0	-0.4	0.2	-0.3	-1.5	-1.2
High blood pressure (mother)	0.5	0.8	1.5	-0.9	-0.5	-1.2	-0.8	-1.2	-0.0
Past tobacco smoking	0.5	0.9	2.4	-0.1	0.6	-1.1	-1.6	1.0	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	3.8	1.4	0.4	1.9	0.9	-0.1	-0.7
Alcohol intake versus 10 years previously	0.5	0.8	3.6	0.3	-0.0	-0.5	-0.3	-1.9	-0.8
Father’s age at death	0.5	0.6	1.8	0.6	1.3	0.5	-0.8	0.5	-0.6
Birth weight of first child	0.5	0.9	1.9	1.3	0.9	0.6	0.8	1.4	0.1
Headache pain in last month	0.5	0.9	2.7	-1.6	-1.5	-0.7	0.0	-0.6	0.1
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	4.2	-2.0	0.1	0.6	-0.6	-0.0	-0.2
Medication: Ventolin 100micrograms inhaler	0.5	0.7	2.5	-0.5	-1.6	-0.3	-0.4	-0.0	1.1
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.3	0.4	-1.0	0.5	1.0	-1.1	-0.4
High blood pressure (siblings)	0.5	0.7	1.7	0.2	1.3	0.1	-1.2	0.8	-0.5
Forced vital capacity (FVC), Best measure	0.5	1.7	6.0	-1.7	-0.8	-2.5	-0.3	-0.4	-0.4
Eye problems/disorders: None of the above	0.5	0.6	2.1	-0.4	0.3	0.4	-0.6	1.5	-0.9
Medication for pain relief, constipation, heartburn	0.5	0.8	3.8	0.7	0.2	0.4	-0.7	2.0	-0.1
Medication: Blood pressure	0.5	0.8	3.6	1.9	0.6	-0.1	0.7	0.7	0.1
Medication: Omeprazole	0.5	0.6	1.8	0.4	1.2	0.5	1.3	0.1	0.3
Medication: Seretide 50 evohaler	0.5	0.6	1.5	0.8	0.8	0.2	-0.9	0.0	-1.2
Leg fat mass (right)	0.5	2.1	6.2	2.5	1.7	1.1	1.2	-0.5	-0.6
Suffer from ‘nerves’	0.5	0.8	2.6	-0.5	-1.6	0.8	0.0	-0.7	-0.9
Had major operations	0.5	0.6	2.2	-0.2	0.2	-0.6	-0.9	0.6	-1.5
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	3.4	-0.3	0.2	-0.4	-1.8	0.1	-0.6
Loneliness, isolation	0.5	0.7	2.7	-1.6	0.1	-0.7	-0.1	-0.9	0.4
Qualifications: nursing, teaching	0.5	0.8	1.5	0.1	-1.2	-1.2	-0.8	-0.0	1.1
Medication for cholesterol	0.5	0.8	2.2	0.6	-0.4	-0.9	0.8	-0.7	1.5
Arm fat mass (left)	0.5	2.2	6.9	2.6	1.9	1.1	1.1	-0.4	-0.3
Leg fat percentage (left)	0.5	1.6	5.4	2.3	1.1	1.6	0.8	-0.2	-0.2
Diastolic blood pressure, automated reading	0.5	1.6	5.0	-0.3	1.0	-0.5	-2.2	0.3	-1.7
Commuting to job workplace: Cycle	0.5	0.6	1.6	0.3	0.9	0.9	0.0	1.3	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.3	-0.3	-1.5	-0.3	0.7	-0.3	0.8
Bipolar Disorder or Schizophrenia	0.4	1.1	4.5	-2.1	0.1	-0.8	-0.7	0.0	-0.8
Intelligence (Savage-Jansen 2018)	0.4	1.4	3.1	-1.7	-0.6	-0.4	-1.6	1.0	-1.0
Ulcerative Colitis (UC)	0.4	0.7	1.3	-0.7	0.9	-1.1	1.0	0.5	0.8
HDL Cholesterol	0.4	0.7	3.3	-1.8	-0.2	-0.0	-0.8	0.0	-0.3
Schizophrenia (2014)	0.4	0.8	2.6	-1.6	-0.4	-0.4	-0.8	0.0	-1.1
Ulcerative Colitis	0.4	0.6	1.5	-0.8	1.0	-1.2	0.7	0.0	0.0
Heel T-Score	0.4	3.4	8.1	2.8	-0.3	1.7	-0.0	2.9	1.3
Waist Hip Ratio (WHR)	0.4	1.6	4.9	0.9	0.6	1.9	0.1	0.1	-2.2
Respiratory disease	0.4	0.9	2.5	1.0	-1.6	-1.0	-0.7	-0.5	-0.2
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.1	0.7	-1.1	-0.1	-0.4	-1.4	0.3
Average weekly spirits intake	0.4	0.5	1.6	-0.1	-0.3	1.3	-0.3	-0.6	-0.8
Ever had hysterectomy (womb removed)	0.4	0.4	1.0	0.9	-0.4	0.4	-0.1	-1.0	-0.6
Systolic blood pressure, automated reading	0.4	1.3	4.8	0.3	0.5	-0.8	-2.2	-0.1	-1.4
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.0	-1.0	-0.3	-0.5	0.2	-0.9	0.5
Medication: Metformin	0.4	0.6	1.3	1.1	-0.9	1.1	-0.3	-0.6	-0.4
Hand grip strength (right)	0.4	1.2	2.5	-1.2	1.0	-1.6	-1.1	0.9	0.3
Taking other prescription medications	0.4	0.6	2.2	0.7	0.3	1.5	0.9	-0.0	0.1
High blood pressure	0.4	1.1	3.3	0.1	0.9	-0.4	-1.5	0.4	-1.8
Number of incorrect matches in round	0.4	0.6	1.2	-0.7	-1.0	-0.2	-1.0	-0.2	-1.1
Financial difficulties in last 2 years	0.4	0.5	1.8	-1.4	-0.6	-0.3	-0.3	-0.4	-0.9
Pain all over the body in last month	0.4	0.5	1.2	-0.2	0.3	1.1	-0.1	0.6	-1.1
Diabetes (self-reported)	0.4	0.6	1.8	1.4	-0.3	0.3	-0.5	-1.0	-0.7
Illnesses of siblings	0.4	0.5	1.2	-0.7	-0.8	-1.1	-0.1	-0.9	0.1
Weight	0.4	1.9	5.2	2.3	1.9	0.9	0.8	-0.4	-1.0
Impedance of arm (right)	0.4	1.9	6.5	0.9	-0.8	1.3	2.6	-1.1	0.7
Hip circumference	0.4	1.7	4.7	2.2	1.3	0.8	1.4	-1.0	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.9	-1.4	-1.1	-0.1	0.6	-0.7	0.5
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	4.8	-1.8	-0.5	-2.2	-0.5	-0.4	-0.1
Mouth/teeth dental problems: Dentures	0.4	0.6	2.2	-0.3	0.6	0.8	-0.6	-0.2	-1.5
Depression (self-reported)	0.4	0.5	0.9	-0.8	-0.3	-0.7	0.7	-0.9	0.5
Lung cancer (father)	0.4	0.4	1.4	0.0	-0.6	0.5	-0.8	-1.2	-0.4
Pulse wave Arterial Stiffness index	0.4	0.5	0.8	-0.5	0.5	0.9	-0.6	0.8	-0.7
Impedance of arm (left)	0.4	1.8	6.8	0.8	-0.7	1.4	2.6	-0.7	0.7
Hair/balding pattern: Pattern 4	0.4	1.1	3.1	-1.5	-0.3	-0.6	-0.6	-1.8	-0.4
Medication: Amlodipine	0.4	0.5	1.4	0.2	1.2	0.9	0.1	0.7	-0.5
Leg fat percentage (right)	0.4	1.4	4.5	2.1	0.9	1.2	1.1	-0.4	0.1
Wheeze or whistling in the chest in last year	0.4	0.7	1.4	1.2	0.3	-0.1	0.8	-1.0	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.0	-1.0	-0.8	0.4	-0.5	-0.0	-0.7
Pulse rate, automated reading	0.4	1.3	3.4	0.7	0.4	1.9	0.3	-1.6	-1.1
Family relationship satisfaction	0.4	0.5	2.3	-0.3	-1.5	0.0	-0.2	-0.3	-0.8
Knee pain experienced in last month	0.4	0.6	1.9	-1.0	-0.4	-0.9	-1.4	-0.0	-0.0
Hypertension (Self-reported)	0.4	1.2	4.1	0.0	1.1	-0.5	-1.4	0.1	-2.0
Long-standing illness, disability or infirmity	0.4	0.7	1.1	1.1	-1.0	0.3	-0.2	-1.0	-0.8
Diabetes diagnosed by doctor	0.4	0.6	1.9	0.9	-0.9	0.4	-0.2	-1.4	-0.4
Breast cancer (self-reported)	0.4	0.5	2.5	0.3	1.6	-0.3	0.5	-0.5	0.0
Mother’s age at death	0.4	0.5	2.5	-0.3	0.1	1.6	0.5	0.4	-0.3
Ever smoked	0.4	0.8	1.5	0.6	-0.9	1.0	1.2	-0.8	-0.6
Cholesterol lowering medication	0.4	0.6	2.0	-1.4	-0.7	-0.0	-0.3	1.1	-0.3
Bipolar Disorder (2018)	0.3	0.4	1.0	-1.0	0.6	0.5	-0.9	0.0	-0.4
Neuroticism (Nagel 2018)	0.3	0.7	3.9	-2.0	-0.5	-0.4	-0.0	0.1	0.2
Crohns Disease (2012)	0.3	0.4	2.2	-0.3	-0.2	1.5	0.5	0.0	0.0
Blood Eosinophil Count	0.3	2.5	6.1	2.5	-0.5	-1.8	1.4	0.6	1.7
Blood White Count	0.3	2.3	8.2	1.8	2.9	-0.5	1.4	-0.4	-0.1
BMI	0.3	1.8	5.1	2.3	1.4	0.8	1.2	-0.0	1.1
Cardiovascular Disease	0.3	1.0	3.0	-0.3	-0.1	-0.9	-1.7	0.2	-1.5
Neuroticism	0.3	0.8	2.5	-1.6	-1.2	0.0	-0.2	-0.5	-0.7
Sensitivity / hurt feelings	0.3	0.6	1.7	-0.5	-0.2	1.3	0.1	1.1	-0.5
Medication for hormone replacement therapy	0.3	0.4	0.9	0.6	0.9	0.3	0.0	-0.4	-0.9
Diabetes (mother)	0.3	0.4	0.8	0.4	-0.0	0.9	0.8	0.7	0.3
Impedance of leg (right)	0.3	1.6	5.9	0.8	-0.4	1.5	2.4	-0.2	0.9
Current tobacco smoking	0.3	0.5	1.5	-0.1	0.1	-0.3	0.1	-1.2	-1.0
Average weekly fortified wine intake	0.3	0.3	1.0	0.2	-0.5	-0.1	-0.6	-0.5	-1.0
Impedance of leg (left)	0.3	1.5	4.1	1.0	-0.2	2.0	2.0	-0.2	0.3
Nervous feelings	0.3	0.6	1.7	-1.1	-1.3	0.1	-0.6	0.2	-0.5
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.2	-0.7	-0.2	-0.1	0.4	0.0	-1.1
Allergy	0.3	0.7	1.4	0.2	1.2	1.1	0.9	-0.7	-0.2
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.5	0.1	-1.2	0.5	-0.8	0.2	-0.1
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.4	0.4	-0.5	-0.3	-0.3	1.2	1.2
Asthma	0.3	0.6	1.2	0.9	-0.7	-1.1	-1.0	-0.2	-0.4
Medication: Cholesterol lowering	0.3	0.5	1.4	1.2	-0.4	-0.8	0.5	-0.6	-0.0
Peak expiratory flow (PEF)	0.3	0.8	3.1	-1.8	-0.9	-0.5	-0.3	-0.2	-0.6
Medication: Paracetamol	0.3	0.6	0.9	-0.9	-0.9	-0.6	0.5	-0.8	0.8
Pulse wave peak to peak time	0.3	0.4	0.8	0.4	-0.6	-0.9	0.3	-0.9	0.2
Emphysema/chronic bronchitis	0.3	0.3	0.8	0.8	-0.9	0.0	-0.4	-0.3	-0.5
Leg pain on walking	0.3	0.4	1.8	-0.3	0.3	0.0	0.1	1.4	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.7	0.9	0.5	0.4	0.4	-0.4	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	2.1	-0.2	-1.4	-0.2	0.7	-0.2	-1.2
Average weekly red wine intake	0.3	0.5	1.0	0.7	-0.8	-0.3	0.7	0.6	1.0
Eye problems/disorders: Cataract	0.3	0.3	1.1	0.3	0.1	0.4	0.7	-1.1	0.1
Back pain experienced in last month	0.3	0.4	1.0	-1.0	-0.8	-0.4	0.0	-0.9	-0.0
Asthma (self-reported)	0.3	0.7	1.4	0.6	-1.1	-1.0	-1.2	0.0	-0.4
Eye problems/disorders: Glaucoma	0.3	0.3	1.7	0.1	0.4	-0.1	-0.2	-1.3	-0.2
Pain experienced in last month	0.3	0.4	1.1	-0.3	0.0	-0.8	-1.0	-0.8	-0.5
Impedance of whole body	0.3	1.7	5.8	1.1	-0.7	1.5	2.4	-0.6	0.5
Depressed Affect (Nagel 2018)	0.2	0.5	2.0	-1.4	-0.0	-0.5	0.6	0.2	0.3
Schizophrenia vs Biploar Disorder	0.2	0.2	1.0	1.0	0.2	-0.0	0.3	0.0	-0.3
Alzheimer’s Disease (in mother)	0.2	0.2	0.8	0.1	-0.2	-0.0	0.9	0.3	0.5
LDL Cholesterol	0.2	0.3	1.8	-0.1	1.4	0.1	0.4	0.0	-0.1
Primary Biliary Cirrhosis	0.2	0.4	1.1	-0.0	1.1	0.6	-0.1	0.0	-0.8
Height	0.2	4.8	9.2	2.3	1.6	2.3	2.5	-0.1	-3.0
Number of treatments/medications taken	0.2	0.3	0.9	0.9	-0.3	0.4	-0.5	0.3	-0.5
Supplements: Zinc	0.2	0.2	0.6	-0.5	0.7	0.1	-0.8	0.1	-0.4
Fed-up feelings	0.2	0.4	1.8	-1.3	-0.6	-0.2	0.5	0.4	-0.1
Relative age voice broke	0.2	0.3	1.4	0.0	-0.1	1.2	0.6	0.1	-0.2
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.7	0.8	0.6	-0.2	0.3	0.5	-0.3
Body mass index (BMI)	0.2	1.0	3.5	1.9	1.4	0.6	0.2	-0.1	-0.1
Hearing difficulty/problems with background noise	0.2	0.4	0.9	0.2	0.9	-1.0	-0.1	-0.7	-0.2
Hair/balding pattern: Pattern 2	0.2	0.2	0.6	0.8	0.2	-0.1	0.6	-0.4	0.1
Falls in the last year	0.2	0.2	0.6	0.0	-0.4	-0.5	0.7	-0.1	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	2.6	-1.2	-0.5	-1.6	0.0	-0.4	0.0
Standing height	0.2	1.9	5.4	1.3	1.5	0.8	1.2	-0.5	-2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.3	-0.2	0.7	0.8	0.1	-0.8
Arm fat-free mass (right)	0.2	0.8	2.5	0.8	1.6	-0.2	-0.3	0.3	-1.1
Age at first live birth	0.2	0.3	0.8	-0.4	0.0	0.7	-0.7	0.9	-0.1
Shortness of breath walking on level ground	0.2	0.3	0.7	0.1	-0.8	-0.1	-0.0	-0.6	-0.8
Qualifications: College or University degree	0.2	0.5	1.9	-0.1	-0.3	-1.4	-0.5	-0.3	0.9
Neck or shoulder pain in last month	0.2	0.3	1.0	-0.4	0.2	0.3	-0.4	-0.4	-1.0
Alcohol intake frequency.	0.2	0.6	1.2	0.3	0.4	0.1	-1.1	0.9	1.1
Comparative height size at age 10	0.2	0.9	3.2	0.7	0.6	0.4	1.8	-0.5	-0.9
Overall health rating	0.2	0.4	1.0	0.0	-0.3	-0.4	1.0	-0.7	-0.8
Age at last live birth	0.2	0.3	1.2	-0.0	0.5	-0.2	0.3	1.1	0.3
Osteoarthritis (self-reported)	0.2	0.3	1.1	-0.3	0.2	0.4	-0.4	-0.5	-1.1
Smoking status: Current	0.2	0.4	1.1	-0.1	0.2	-0.2	0.0	-1.0	-1.0
Commuting to job workplace: Public transport	0.2	0.3	0.9	-0.0	0.2	0.9	-0.7	0.5	0.3
High cholesterol (Self-reported)	0.2	0.3	1.4	-0.2	-1.2	-0.3	0.2	0.3	-0.7
Medication: Paracetamol	0.2	0.3	0.7	-0.3	-0.6	-0.0	0.6	-0.3	0.8
Arm fat-free mass (left)	0.2	0.8	2.1	1.1	1.5	-0.0	-0.1	0.1	-1.1
Ever depressed for a whole week	0.2	0.3	0.8	-0.3	0.9	0.0	0.3	0.9	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	1.0	-0.5	0.4	-0.3	1.0	-0.0	0.4
Heart disease (siblings)	0.2	0.2	0.9	-0.2	0.0	-0.6	-0.9	0.3	0.3
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.4	-0.4	-0.1	-0.1	-0.6	1.2	0.1
Body Mass Index (BMI) (2010)	0.1	0.2	0.4	-0.6	0.4	-0.5	-0.4	0.0	0.3
Neuroticism (2016)	0.1	0.1	0.4	-0.4	-0.2	-0.4	0.3	-0.6	0.1
Lung FEV1/FVC ratio	0.1	0.6	1.9	0.6	1.4	1.2	0.2	-0.3	0.1
Leg fat-free mass (left)	0.1	0.7	2.2	0.8	1.5	-0.5	0.2	0.0	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.6	-0.6	0.1	-0.8	-0.4	-0.2	0.0
Sitting height	0.1	0.4	1.1	0.0	0.5	-0.5	1.0	-0.3	-1.1
Leg predicted mass (left)	0.1	0.6	2.0	0.8	1.4	-0.5	0.0	-0.1	-0.9
Trunk fat-free mass	0.1	0.6	1.6	0.6	1.2	-0.4	-0.4	0.2	-1.3
Trunk predicted mass	0.1	0.7	1.9	0.6	1.1	-0.4	-0.5	0.2	-1.4
Health satisfaction	0.1	0.2	0.7	0.2	0.0	-0.4	0.8	-0.5	-0.1
Arm predicted mass (right)	0.1	0.7	2.5	0.8	1.6	-0.5	-0.2	0.2	-1.0
Whole body fat-free mass	0.1	0.7	1.8	0.7	1.3	-0.4	-0.2	0.0	-1.2
Leg fat-free mass (right)	0.1	0.7	2.2	0.7	1.5	-0.4	-0.2	-0.0	-1.2
Osteoporosis (self-reported)	0.1	0.1	0.2	0.3	0.5	-0.2	-0.3	0.1	-0.2
Whole body water mass	0.1	0.6	1.8	0.7	1.3	-0.5	-0.2	0.1	-1.1
Leg predicted mass (right)	0.1	0.7	2.2	0.7	1.5	-0.3	-0.2	-0.0	-1.2
Basal metabolic rate	0.1	0.8	2.4	1.1	1.6	-0.0	0.2	0.1	-1.0
Supplements: Calcium	0.1	0.1	0.3	-0.1	0.1	0.4	0.4	0.3	0.6
Arm predicted mass (left)	0.1	0.7	2.0	1.0	1.4	-0.3	-0.0	-0.0	-1.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	1.2	3.5	1.0	0.9	0.8	-0.9	1.9	0.5
Tanning	0.0	0.3	1.3	0.0	0.2	-0.4	1.2	0.3	0.4
Worry too long after embarrassment	0.0	0.1	0.1	-0.3	0.3	-0.1	0.2	-0.4	-0.1

Hub : Genes

TMC6

Models

Trait associations