Hub : Genes

USP36

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1400	0.0310	1.3e-11	0.126	0.086	0.122	0.099	0.130	4.6e-15	1.2e-10	1.1e-14	4.4e-12	1.7e-15
2	GTEx	Brain Cerebellar Hemisphere	0.5050	0.1290	1.4e-04	0.163	NA	0.075	NA	0.012	5.7e-05	NA	5.7e-03	NA	1.5e-01
3	GTEx	Brain Cerebellum	0.3090	0.0910	6.2e-04	0.199	NA	0.133	NA	-0.008	1.6e-06	NA	9.7e-05	NA	6.6e-01
4	GTEx	Brain Nucleus accumbens basal ganglia	0.3610	0.1020	1.9e-04	0.233	NA	0.137	NA	0.199	6.7e-07	NA	1.7e-04	NA	4.8e-06
5	GTEx	Esophagus Mucosa	0.1090	0.0390	1.5e-03	0.042	NA	0.057	NA	0.049	8.6e-04	NA	1.1e-04	NA	3.2e-04
6	GTEx	Esophagus Muscularis	0.1760	0.0500	1.6e-05	0.155	NA	0.046	NA	0.075	1.1e-09	NA	8.3e-04	NA	2.5e-05
7	GTEx	Testis	0.3170	0.0670	2.0e-08	0.241	NA	0.180	NA	0.260	4.5e-11	NA	2.1e-08	NA	6.2e-12
8	GTEx	Thyroid	0.2050	0.0440	1.6e-09	0.150	NA	0.163	NA	0.151	1.4e-11	NA	1.6e-12	NA	1.2e-11
9	TCGA	Brain Lower Grade Glioma	0.0361	0.0231	9.7e-03	0.003	0.009	0.008	NA	0.006	1.4e-01	2.9e-02	3.9e-02	NA	5.5e-02
10	TCGA	Rectum Adenocarcinoma	0.3820	0.1180	8.9e-04	0.237	0.147	0.173	NA	0.177	2.7e-06	2.7e-04	7.3e-05	NA	6.2e-05
11	TCGA	Testicular Germ Cell Tumors	0.1030	0.0610	1.4e-03	0.020	0.042	0.031	NA	0.052	6.2e-02	1.3e-02	2.9e-02	NA	6.6e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.5	0.7	1.8	-0.7	-0.5	-0.3	-0.4	-1.3	1.0	-0.8	-1.3	-0.2	-1.0	-1.1
Bipolar Disorder or Schizophrenia	0.3	0.6	3.5	0.5	0.9	-0.1	0.9	0.0	0.2	0.5	-0.3	0.8	-1.9	-0.5
Depressed Affect (Nagel 2018)	0.3	0.5	1.6	0.3	1.1	-0.2	0.6	0.7	0.4	0.9	0.8	-0.4	-0.6	1.3
Depression (Nagel 2018)	0.0	0.1	0.2	0.2	-0.1	0.3	0.3	-0.3	-0.1	0.5	0.3	-0.0	0.1	0.3
Intelligence (Savage-Jansen 2018)	1.1	3.2	7.1	-1.7	-1.5	-1.4	-1.6	-2.3	1.8	-1.9	-2.3	-1.2	-0.2	-2.7
Neuroticism (Nagel 2018)	1.4	3.3	7.0	1.8	2.3	0.6	2.0	1.7	-1.2	2.2	2.2	0.9	-1.3	2.6
Schizophrenia (2018)	0.6	1.2	2.6	1.2	1.5	0.1	1.3	1.1	-0.5	1.2	0.6	1.1	-1.6	0.3
Schizophrenia vs Biploar Disorder	1.3	1.7	3.4	1.4	1.8	0.9	1.2	1.6	-1.1	1.4	1.8	0.7	-1.2	0.8
Worry (Nagel 2018)	2.3	4.9	7.9	2.3	2.6	1.0	2.6	1.8	-2.1	2.4	2.4	1.6	-2.0	2.8
Alzheimer’s Disease (in mother)	0.3	0.3	1.5	0.2	0.7	-0.2	0.3	0.7	-0.1	0.4	1.2	0.1	-0.0	0.9
Alzheimer’s Disease (in father)	1.5	1.6	4.5	-1.5	-1.9	-0.8	-1.0	-0.2	2.1	-0.8	-1.2	-0.1	1.5	-1.3
Alzheimer’s Disease (including proxy)	0.6	0.8	3.4	-1.2	-0.8	-1.1	-1.1	-0.3	1.9	-0.3	-0.0	-0.4	0.9	-0.2
Crohns Disease (2017)	1.8	4.0	7.1	2.1	2.2	1.1	2.6	1.5	-2.0	2.2	2.3	1.2	-1.6	2.7
Irritable Bowel Disease (IBD)	4.4	10.5	17.4	3.6	3.5	2.8	4.2	2.1	-3.4	3.5	2.8	2.3	-3.2	3.6
Ulcerative Colitis (UC)	5.0	9.4	14.9	3.4	3.5	3.1	3.9	1.5	-3.2	3.2	2.1	2.1	-3.4	3.3
Major Depression (MDD)	0.0	0.1	0.4	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.4	0.0	-0.6
Reaction Time	2.0	3.9	6.7	2.3	1.8	1.8	2.6	1.7	-1.9	2.0	2.4	2.3	-1.6	0.7
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.1	-0.0	-0.6	-0.4	-0.1	-1.0	0.0	-0.5	-0.5	-0.1	-0.6	-1.1
Breast Cancer	0.1	0.2	0.7	-0.2	-0.5	0.8	-0.3	-0.3	0.4	0.2	0.2	-0.5	0.4	0.3
Ovarian Cancer	1.8	2.4	5.6	1.7	1.2	1.8	1.6	1.2	-1.6	1.9	1.3	0.7	-0.7	2.4
Prostate Cancer	3.7	5.1	7.7	2.7	2.2	2.2	2.8	2.5	-1.9	2.4	2.3	2.4	-1.3	1.7
Age at First Birth	1.8	2.6	4.0	-1.7	-2.0	-0.9	-1.9	-1.9	1.7	-1.6	-1.8	-1.6	0.2	-1.5
Bipolar Disorder (2011)	0.1	0.1	0.4	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.3	-0.4	0.6
Body Mass Index (BMI) (2010)	0.5	0.6	1.5	-0.6	-1.0	-1.2	-0.9	-0.2	0.6	-0.9	-0.6	-0.7	-0.1	-1.1
Coronary Artery Disease (CAD)	3.6	4.3	6.6	-2.6	-2.2	-2.0	0.0	-2.5	2.2	-2.6	-1.6	-1.5	2.1	-2.2
Crohns Disease (2012)	0.4	0.7	2.4	0.9	0.5	0.6	0.0	-0.2	-0.8	0.7	1.1	-0.4	-1.6	0.9
Mean Putamen Volume	2.5	2.8	4.5	2.1	2.1	1.5	1.4	2.1	-1.7	1.7	1.5	1.9	-1.4	0.4
Fasting Glucose	0.2	0.3	1.2	0.5	0.1	0.1	0.7	0.7	-1.1	-0.0	-0.2	0.4	0.5	0.6
HbA1C	0.8	0.9	4.5	-0.5	-0.6	0.1	-0.4	-0.8	0.7	-1.0	-2.1	0.7	0.9	-0.9
HDL Cholesterol	1.2	1.9	4.9	1.4	1.7	0.5	1.6	-0.3	-1.4	1.6	1.8	0.5	-0.4	2.2
LDL Cholesterol	0.4	0.6	2.7	0.7	0.7	1.7	0.5	0.1	-0.6	0.3	-0.7	1.3	0.0	-0.0
Lupus	1.5	2.3	3.7	-1.9	-1.9	-0.7	-1.6	-1.7	1.7	-1.6	-1.7	-1.5	0.6	-0.9
Neuroticism (2016)	1.1	1.6	3.2	1.6	1.0	1.2	0.8	1.4	-1.4	1.3	1.8	0.4	0.1	1.6
Primary Biliary Cirrhosis	2.5	3.6	5.4	2.1	2.1	1.5	2.0	0.7	-2.0	2.3	2.3	1.2	-2.0	2.0
Rheumatoid Arthritis	1.3	1.9	3.8	-1.4	-1.4	-0.6	-1.2	-1.6	1.7	-1.2	-2.0	-1.6	-0.1	-1.2
Schizophrenia (2014)	0.9	1.9	4.1	1.6	1.6	0.8	1.8	1.6	-0.9	1.3	1.0	1.4	-2.0	0.2
Triglycerides	1.1	1.7	3.2	-1.5	-1.2	-0.5	-1.4	-0.6	1.6	-1.8	-1.7	-0.9	0.3	-1.8
Type 2 Diabetes (T2D) (2012)	1.6	1.8	4.2	-1.1	-1.7	-1.1	-1.3	-1.8	0.4	-1.4	-1.5	-2.0	-0.0	-1.0
Ulcerative Colitis	4.3	6.2	11.2	2.9	2.8	2.2	3.3	1.0	-2.4	2.9	2.1	1.5	-3.1	2.1
Blood Eosinophil Count	0.1	0.6	2.6	0.6	0.3	1.2	0.0	-0.8	-0.5	0.9	0.6	-0.5	-0.4	1.6
Blood Platelet Count	0.1	0.9	1.8	-0.6	-1.0	-0.6	-0.4	1.0	0.3	-0.8	-1.2	0.9	1.4	-1.4
Blood Red Count	2.1	20.7	33.6	4.9	4.8	4.5	4.8	5.8	-5.1	4.1	4.7	4.3	-1.9	4.3
Blood White Count	0.4	2.8	5.2	-1.7	-0.7	-0.8	-1.5	-2.1	1.6	-1.6	-2.1	-2.2	-2.3	-0.9
Heel T-Score	1.6	12.7	41.3	3.2	3.5	5.0	2.7	3.5	-2.3	2.8	3.1	2.6	-6.4	1.3
BMI	2.3	13.5	22.4	-4.3	-4.1	-3.0	-4.7	-2.4	4.0	-4.0	-3.7	-3.0	3.4	-3.2
Height	3.3	63.3	104.0	-8.7	-7.9	-6.6	-8.8	-10.2	8.2	-8.4	-9.0	-7.4	3.6	-6.8
Waist Hip Ratio (WHR)	0.1	0.7	1.9	-1.0	-0.7	0.2	-1.0	-0.8	1.4	-0.7	-1.0	-0.6	0.7	0.3
Systolic Blood Pressure	7.4	37.0	59.0	-7.0	-4.8	-6.0	-7.2	-7.7	5.8	-6.6	-5.3	-6.8	1.7	-5.8
Smoking Status	1.1	2.6	6.0	1.2	0.0	2.5	1.4	2.3	-0.8	1.3	1.5	2.3	1.3	1.4
Allergy or Eczema	0.1	0.3	1.5	-0.6	-0.3	-0.7	-0.4	-1.2	0.5	-0.4	0.2	-0.6	0.3	-0.1
Cardiovascular Disease	8.1	26.7	37.8	-6.0	-5.3	-5.5	-6.2	-5.9	4.8	-5.8	-4.1	-5.0	1.9	-5.0
Hypothyroidism (self reported)	0.3	0.7	2.4	-0.4	-0.3	-0.9	-0.9	-1.6	0.1	-0.8	-1.0	-0.8	-0.5	-1.1
Respiratory disease	0.8	1.9	15.1	0.5	1.0	1.3	0.7	-0.7	-0.2	0.4	-0.1	-0.8	-3.9	-0.8
Type 2 Diabetes (T2D) (2018)	2.1	3.9	6.2	-2.4	-2.4	-1.3	-2.5	-1.9	2.5	-1.8	-1.9	-2.0	0.8	-1.6
Lung FEV1/FVC ratio	0.4	1.8	7.6	-1.2	-1.4	-0.2	-1.9	-0.9	-0.7	-1.5	-1.0	-0.5	2.8	-0.4
Lung FVC	2.3	11.7	18.6	4.0	3.7	2.4	4.2	4.3	-3.4	3.7	3.2	3.8	-1.7	2.3
Neuroticism	1.6	3.7	8.5	2.0	2.9	1.2	2.0	1.4	-1.8	1.9	2.4	1.7	-1.8	1.6
Chronotype (morning person)	0.2	0.4	2.0	0.1	-0.3	0.2	0.5	0.7	0.2	0.1	0.4	0.4	1.4	1.2
Hair Pigment	0.3	10.0	15.2	3.5	2.3	3.8	3.3	3.9	-3.6	3.5	2.8	3.2	-0.5	3.1
Tanning	0.1	1.5	6.1	0.7	-0.4	0.1	1.1	1.7	-0.7	0.4	1.0	1.2	2.5	1.6
Hand grip strength (left)	1.1	3.0	6.0	-1.8	-2.1	-1.8	-2.5	-2.3	0.8	-2.1	-1.6	-1.1	0.0	-1.5
Number of treatments/medications taken	0.5	0.8	2.0	-1.3	-0.7	-0.2	-1.2	-1.2	0.9	-0.6	-0.4	-1.4	0.1	-0.8
Average weekly spirits intake	0.2	0.3	1.3	-0.6	-0.4	-0.1	-0.3	-0.1	0.9	-0.1	-0.2	-0.0	1.1	-0.5
Sensitivity / hurt feelings	0.1	0.2	1.0	0.4	1.0	-0.2	0.1	-0.1	-0.8	-0.1	0.4	0.5	-0.3	-0.3
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.6	-0.6	-0.7	-1.0	-0.5	-1.3	0.7	-0.7	-0.8	0.1	0.4	-0.3
Hearing difficulty/problems: Yes	0.2	0.3	1.5	-0.2	-0.8	-0.8	-0.2	0.6	0.4	0.1	-0.1	0.0	1.2	-0.3
Relative age of first facial hair	0.2	0.5	1.3	-0.6	-0.6	-0.0	-1.0	0.1	1.1	-0.3	-0.2	-0.7	1.0	-1.0
Other serious medical condition/disability diagnosed by doctor	4.0	5.2	10.4	-2.4	-2.1	-2.1	-2.4	-3.2	2.8	-2.3	-1.7	-2.3	-0.9	-2.3
Ever used hormone-replacement therapy (HRT)	2.8	3.5	8.2	1.4	1.0	1.4	1.9	2.9	-1.2	1.9	2.5	2.0	1.5	2.1
Ever had hysterectomy (womb removed)	1.0	1.1	2.7	1.2	0.9	1.0	0.8	1.6	-1.1	0.9	1.2	1.2	-0.4	0.8
Systolic blood pressure, automated reading	8.8	25.6	36.2	-5.9	-3.7	-5.3	-6.0	-5.8	5.2	-5.4	-4.0	-6.0	2.4	-4.8
Eye problems/disorders: Diabetes related eye disease	3.6	3.9	5.9	-2.1	-1.9	-1.1	-2.3	-2.4	2.4	-1.9	-1.8	-1.7	1.1	-2.4
Angina	2.9	3.9	6.4	-2.2	-2.4	-1.5	-2.5	-1.4	2.4	-1.6	-1.9	-1.6	1.8	-1.8
Medication for hormone replacement therapy	5.1	5.7	8.0	2.6	2.2	2.2	2.5	2.6	-2.8	2.5	2.4	2.4	-0.3	2.6
Vitamin and mineral supplements	0.1	0.2	0.7	-0.4	-0.2	-0.9	-0.7	-0.0	0.3	-0.6	-0.0	0.2	0.2	0.2
Supplements: Zinc	0.9	0.9	3.2	-1.3	-0.6	-0.8	-0.6	-1.0	1.8	-0.6	-1.2	-0.7	0.1	-0.9
Medication: Co-codamol	0.3	0.4	1.3	0.3	-0.1	1.1	-0.2	0.8	-0.1	0.2	0.0	1.2	0.9	-0.1
Medication: Metformin	1.3	1.8	4.0	-1.3	-1.1	-0.3	-1.6	-2.0	1.1	-1.3	-1.5	-1.1	-1.1	-1.6
Diabetes (father)	1.0	1.3	3.7	-1.3	-0.9	-1.3	-1.2	-0.5	1.9	-1.0	-0.8	-1.5	0.5	-0.5
Diabetes (mother)	2.5	3.2	6.5	-2.4	-1.1	-1.3	-2.0	-1.6	1.6	-2.2	-2.2	-2.5	0.2	-1.1
Severe depression (siblings)	0.4	0.5	2.1	0.3	0.1	-0.1	0.4	0.7	-0.6	0.3	1.5	0.8	0.9	0.8
Pack years adult smoking proportion	0.4	0.6	2.6	-0.5	-1.0	-0.4	-0.8	0.2	-0.0	-0.7	-0.7	-0.3	1.6	-1.0
Impedance of leg (right)	0.6	2.9	5.1	1.6	1.7	1.9	2.1	0.2	-1.9	1.3	1.6	0.4	-2.1	2.2
Leg fat-free mass (left)	6.1	32.3	47.7	-6.2	-6.0	-5.6	-6.9	-5.9	5.8	-6.0	-5.8	-4.7	3.4	-5.5
Trunk fat percentage	2.4	9.6	14.9	-3.7	-2.9	-3.5	-3.9	-2.7	3.2	-3.4	-2.4	-3.1	2.3	-2.8
Hand grip strength (right)	1.5	4.1	9.1	-2.0	-3.0	-2.1	-2.6	-2.3	1.0	-2.5	-1.7	-0.7	0.4	-2.3
Townsend deprivation index at recruitment	0.2	0.2	0.9	0.1	-0.4	0.1	0.2	0.1	-0.5	-0.3	0.1	1.0	0.8	0.5
Current tobacco smoking	0.5	0.7	2.9	0.3	-0.5	0.4	0.7	1.2	-0.3	0.5	0.3	1.2	1.7	0.9
Average weekly fortified wine intake	0.6	0.7	2.7	0.9	0.7	1.6	0.6	0.6	-0.9	0.8	0.7	0.3	-0.9	-0.3
Maternal smoking around birth	0.1	0.1	0.5	-0.2	0.0	0.2	0.2	0.5	0.6	0.1	0.3	-0.5	0.3	0.7
Fed-up feelings	0.8	1.5	5.9	1.1	2.4	0.3	1.2	1.2	-0.7	1.4	0.9	0.8	-0.9	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.6	0.4	0.8	0.4	0.3	-0.2	-0.1	0.3	-0.1	0.5	-0.6	0.5
Relative age voice broke	1.4	2.2	4.7	1.4	1.4	1.5	1.4	1.5	-0.6	1.9	2.0	1.0	0.4	2.2
Taking other prescription medications	0.2	0.3	1.2	-0.1	0.9	0.3	-0.1	-0.1	0.3	0.4	0.7	-0.7	-1.1	-0.1
Age when periods started (menarche)	0.2	0.4	1.9	-0.3	-1.0	-0.6	-0.1	-0.9	0.3	-0.1	-1.4	-0.3	0.4	-0.0
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.2	-0.2	-0.5	-0.3	-0.2	1.1	0.2	0.1	0.5	0.6	1.0	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	5.2	-0.2	1.1	-0.3	-0.2	1.0	0.6	-0.1	0.3	0.4	-2.3	-0.6
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	1.0	-0.2	-1.0	-0.6	-0.6	0.2	-0.0	-0.0	-0.4	-0.1	1.0	0.0
Qualifications: CSEs or equivalent	0.1	0.1	0.5	0.0	0.2	-0.7	-0.1	-0.5	0.0	-0.1	-0.4	0.1	-0.1	0.3
Serious illness, injury or assault to yourself	0.1	0.2	0.5	0.2	-0.5	0.6	0.2	0.3	-0.4	0.1	0.2	-0.7	0.4	0.5
High blood pressure	3.3	9.1	13.8	-3.7	-2.9	-2.9	-3.7	-3.7	3.1	-3.2	-2.0	-3.0	0.9	-3.0
Hayfever, allergic rhinitis or eczema	0.3	0.6	3.3	-0.8	-0.0	-0.8	-0.6	-1.8	0.4	-0.9	-0.2	-0.8	-0.2	-0.2
Multivitamins +/- minerals	0.1	0.2	0.8	0.1	0.1	0.3	0.1	-0.4	-0.1	0.2	-0.0	-0.9	-0.0	-0.9
Stomach or abdominal pain in last month	2.7	3.4	4.9	-1.8	-1.4	-1.9	-2.1	-2.1	2.0	-2.2	-2.0	-1.6	0.2	-2.0
Supplements: Glucosamine	2.1	2.7	3.6	-1.9	-1.9	-1.6	-1.8	-1.8	1.6	-1.9	-1.3	-1.6	0.7	-1.6
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.0	-0.3	1.0	-0.7	-0.4	-0.5	0.1	-0.6	0.1	0.1	-0.5	-0.5
Medication: Atenolol	0.6	0.7	2.3	0.4	0.3	1.3	0.2	1.1	0.2	0.9	0.2	0.7	1.5	0.9
Medication: Levothyroxine sodium	0.1	0.2	0.9	-0.0	0.0	-0.8	-0.5	-0.5	-0.3	-0.1	-0.3	-0.5	-0.2	-1.0
Sitting height	1.5	10.7	14.9	-3.4	-3.7	-2.3	-3.9	-3.8	3.1	-3.5	-3.8	-2.9	1.9	-3.1
Chronic bronchitis/emphysema (father)	0.8	1.0	4.7	-1.0	-1.1	-1.1	-0.9	0.2	0.6	-1.1	0.2	-0.3	2.2	0.4
High blood pressure (mother)	5.0	7.0	10.3	-3.2	-2.5	-3.0	-2.8	-2.6	3.2	-3.0	-2.4	-2.2	0.9	-2.4
Body mass index (BMI)	2.0	8.6	14.3	-3.4	-3.0	-3.2	-3.8	-1.9	3.3	-2.9	-2.5	-2.5	2.5	-2.7
Impedance of leg (left)	1.0	4.7	7.4	2.2	2.1	2.6	2.7	1.1	-2.5	1.8	2.2	1.1	-2.1	2.7
Leg predicted mass (left)	6.1	32.4	47.5	-6.3	-6.0	-5.6	-6.9	-5.9	5.9	-6.0	-5.8	-4.7	3.3	-5.5
Trunk fat mass	4.5	19.2	28.8	-5.1	-4.5	-4.5	-5.4	-4.1	4.5	-4.7	-3.9	-4.1	2.9	-4.0
Waist circumference	3.2	11.8	20.2	-4.1	-3.6	-3.2	-4.5	-2.6	3.8	-3.5	-3.0	-3.2	3.3	-2.6
Number of incorrect matches in round	0.2	0.3	1.6	-0.1	-0.2	-0.5	-0.1	-0.4	-0.7	-0.5	-0.1	-0.3	-1.2	0.2
Past tobacco smoking	1.6	2.9	6.9	-1.5	-0.3	-2.6	-1.1	-2.3	1.3	-1.8	-1.6	-2.1	-1.1	-1.8
Alcohol usually taken with meals	0.1	0.2	1.6	0.5	0.2	-0.3	0.1	-0.1	-0.4	-0.1	-0.4	0.3	-1.3	-0.3
Nervous feelings	4.9	9.2	12.6	3.5	3.0	2.2	3.6	2.9	-3.3	3.1	3.5	3.1	-2.0	2.7
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.9	0.2	0.2	-0.6	0.2	-0.7	-0.5	-0.4	-0.4	0.9	-0.7	-0.4
Hearing difficulty/problems with background noise	0.3	0.6	2.2	0.3	-1.0	-0.6	0.3	1.0	-0.2	0.3	-0.3	0.5	1.5	0.9
Hair/balding pattern: Pattern 2	0.1	0.1	0.4	0.1	-0.1	-0.6	-0.0	0.3	0.5	0.2	-0.3	-0.0	0.3	-0.0
Had menopause	0.1	0.1	0.6	0.1	0.0	-0.1	-0.1	0.8	-0.2	0.2	0.4	-0.2	0.6	0.1
Had other major operations	0.2	0.3	1.8	0.3	0.2	0.1	0.2	0.5	-0.5	0.2	0.7	0.1	-1.3	0.3
Forced vital capacity (FVC)	0.2	0.8	2.5	-0.6	-0.5	-0.8	-0.9	-1.1	0.8	-1.0	-1.6	-0.4	-0.0	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	6.0	-0.2	1.0	0.1	-0.6	0.8	0.3	-0.2	0.2	-0.0	-2.4	-0.9
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	2.9	0.7	0.8	1.7	0.5	0.8	-0.8	-0.2	0.2	1.2	0.7	0.0
Qualifications: None of the above	1.5	3.3	7.1	1.6	1.9	2.7	1.4	2.5	-1.9	2.2	2.2	0.4	-0.3	1.1
Financial difficulties in last 2 years	2.4	3.2	5.8	-1.8	-2.0	-1.8	-2.0	-1.8	2.4	-1.6	-1.6	-1.3	0.7	-2.1
Mouth/teeth dental problems	2.0	3.1	9.7	-1.4	-1.3	-1.1	-1.6	-3.1	1.0	-2.0	-1.9	-1.8	-0.5	-2.2
Heart attack	0.1	0.2	0.8	-0.3	0.2	0.6	-0.2	0.9	0.2	-0.0	-0.1	-0.5	0.6	0.2
Allergy	0.2	0.3	2.5	0.0	-0.4	-0.1	-0.2	1.0	0.1	0.1	-0.1	0.2	1.6	-0.1
Pain all over the body in last month	1.9	2.0	3.3	1.5	1.3	1.8	1.5	1.7	-1.3	1.7	0.9	1.6	-0.2	1.3
Diabetes (self-reported)	1.3	2.1	3.4	-1.8	-1.4	-1.0	-1.8	-1.5	1.8	-1.3	-1.3	-1.7	-0.0	-1.2
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	4.9	0.4	-0.1	0.1	0.6	0.6	-0.7	0.4	0.6	1.0	2.2	0.8
Medication: Ramipril	3.5	4.5	8.7	-2.6	-1.9	-1.9	-2.7	-2.9	2.0	-2.1	-1.7	-2.2	1.3	-1.5
Medication: Simvastatin	1.9	2.7	4.9	-2.0	-1.4	-1.2	-2.2	-1.5	1.7	-1.7	-1.6	-1.9	1.2	-1.6
Fluid intelligence score	0.3	0.5	2.7	0.4	-0.1	0.5	-0.0	-0.8	-0.6	-0.3	-0.5	0.2	-1.6	-1.2
Illnesses of siblings	7.2	10.1	15.9	3.8	3.5	2.4	4.0	2.7	-3.3	3.2	2.5	3.7	-1.9	3.3
Neuroticism score	1.3	2.8	5.9	1.8	2.4	0.8	1.7	1.0	-1.9	1.4	1.6	1.9	-1.8	1.3
Weight	6.2	30.5	46.5	-6.2	-6.0	-5.4	-6.8	-5.4	5.8	-5.7	-5.3	-4.9	3.6	-5.0
Impedance of arm (right)	0.2	1.1	2.6	0.9	1.4	0.5	1.3	-0.3	-1.0	0.9	1.0	0.1	-1.6	1.2
Arm fat percentage (right)	2.1	8.2	13.0	-3.4	-2.7	-3.6	-3.6	-2.3	3.1	-2.8	-2.3	-2.5	2.4	-2.4
Trunk fat-free mass	6.2	35.3	51.4	-6.4	-6.8	-5.1	-7.2	-6.4	6.2	-6.2	-6.3	-5.1	3.2	-5.5
Hip circumference	3.6	15.6	25.1	-4.5	-4.3	-4.1	-5.0	-3.5	4.0	-4.0	-3.4	-4.1	2.3	-3.7
Time employed in main current job	0.9	1.1	2.3	0.8	1.5	1.2	1.1	0.3	-1.3	1.0	1.3	0.2	-0.5	1.3
Alcohol intake versus 10 years previously	1.2	1.8	6.5	1.1	1.9	0.5	1.1	0.0	-0.5	1.6	1.6	-0.5	-2.5	0.7
Father’s age at death	0.9	1.3	4.2	-0.8	-1.1	-2.0	-1.1	-0.3	0.6	-0.8	-1.4	0.1	1.1	-1.6
Worrier / anxious feelings	0.7	1.3	7.7	1.1	1.6	-0.1	0.9	-0.3	-1.1	0.7	0.6	0.5	-2.8	0.4
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.8	8.0	-2.2	-1.0	-1.5	-2.3	-2.2	1.7	-2.8	-2.3	-1.8	0.1	-2.0
Falls in the last year	2.5	3.4	6.1	-2.2	-2.5	-2.2	-1.9	-2.0	1.9	-1.7	-1.3	-2.1	0.4	-1.3
Hair/balding pattern: Pattern 3	1.4	2.1	4.7	1.5	0.3	1.9	1.6	1.4	-2.1	1.4	0.9	2.2	0.0	1.0
Number of live births	0.8	1.2	2.9	0.7	0.4	0.7	0.7	1.7	-0.5	1.0	1.4	1.6	1.5	0.7
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	2.8	-0.7	-0.9	-0.8	-1.1	-1.2	0.3	-1.1	-1.7	-0.4	0.4	-0.6
Pulse rate	0.8	1.3	3.3	-1.1	-1.5	-1.8	-0.9	-1.6	0.8	-1.1	-1.1	-0.8	0.4	-0.2
Happiness	0.3	0.4	1.3	-0.6	-0.0	0.3	-0.6	-0.6	1.1	-0.4	-0.3	-0.9	-0.3	-0.9
Noisy workplace	0.7	0.9	3.8	-1.0	-0.2	-0.7	-0.8	-1.9	0.3	-1.1	-0.7	-1.2	0.6	-0.6
Qualifications: A levels/AS levels or equivalent	2.4	5.4	11.2	-2.1	-2.0	-2.4	-2.5	-3.3	1.9	-2.7	-2.7	-1.7	-0.2	-2.7
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	1.3	0.1	0.4	0.4	-0.1	-0.2	-0.5	-0.1	0.5	-0.2	-1.2	-0.4
Mouth/teeth dental problems: Dentures	1.0	1.7	5.8	0.6	0.5	0.5	1.0	2.4	-0.2	1.4	1.9	1.2	1.4	1.5
Asthma	0.3	0.7	5.6	0.1	0.3	0.7	0.3	-0.6	0.1	0.1	0.2	-0.7	-2.4	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.0	-0.7	-1.3	-1.2	-0.5	-0.1	0.5	-1.2	-1.4	1.0	0.8	-0.6
Medication: Cholesterol lowering	2.4	3.8	7.2	-2.3	-2.1	-0.9	-2.7	-1.6	2.3	-2.0	-1.4	-2.0	1.7	-1.8
Depression (self-reported)	0.7	0.8	1.6	-0.9	-1.1	-0.7	-1.0	-0.5	0.6	-1.2	-1.2	-0.5	0.6	-1.2
Medication: Lansoprazole	0.9	1.0	2.9	-1.1	-1.2	0.4	-1.4	-0.2	0.9	-1.1	-1.2	-0.5	1.7	-0.2
Prospective memory result	0.7	0.9	2.2	-0.8	0.3	-0.9	-0.4	-1.5	0.8	-0.7	-1.1	-1.2	-0.5	-1.3
Lung cancer (father)	0.5	0.5	2.1	0.2	-0.2	0.9	0.6	1.5	-0.2	-0.0	0.2	1.2	1.0	0.4
Illnesses of mother	3.7	4.6	7.4	2.7	1.4	2.5	2.3	2.3	-2.7	2.5	1.7	1.8	-0.1	2.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	2.3	-0.6	-0.8	-0.5	-0.8	-0.9	0.5	-0.9	-1.5	-0.6	-0.1	-0.3
Pulse wave Arterial Stiffness index	0.4	0.4	2.2	0.1	-0.1	0.6	0.3	0.4	-0.1	0.4	0.5	0.1	1.5	1.2
Impedance of arm (left)	0.3	1.5	2.7	1.3	1.6	0.9	1.6	0.1	-1.6	1.2	1.3	0.6	-1.4	1.2
Arm fat mass (right)	3.8	15.5	24.4	-4.6	-4.2	-4.3	-4.9	-3.4	4.1	-4.0	-3.5	-3.5	3.0	-3.4
Trunk predicted mass	6.0	34.3	50.0	-6.3	-6.7	-5.1	-7.1	-6.3	6.0	-6.1	-6.1	-5.1	3.1	-5.4
Standing height	4.4	44.0	69.4	-7.0	-7.5	-5.7	-7.7	-8.3	6.3	-7.2	-7.0	-6.0	3.0	-5.8
Length of working week for main job	1.1	1.2	3.0	-1.3	-1.3	-0.5	-1.2	-0.4	1.4	-1.2	-1.7	-0.2	0.6	-1.3
Exposure to tobacco smoke at home	2.3	2.5	6.8	1.2	1.7	1.7	1.9	1.9	-0.6	1.7	1.6	0.3	-1.1	2.6
Breastfed as a baby	1.3	1.6	4.8	1.6	0.4	1.3	1.2	1.3	-1.2	1.4	0.3	2.2	0.3	1.1
Tense / ‘highly strung’	0.5	0.8	3.5	0.1	0.3	-0.7	0.3	1.0	-0.7	0.3	0.7	1.2	1.9	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.0	-0.4	-0.1	-0.7	-0.8	-0.4	-0.3	-1.0	0.1	-0.9	-0.2	-0.3
Hair/balding pattern: Pattern 4	2.0	4.8	10.0	2.1	2.9	3.2	2.1	1.4	-1.9	2.4	2.4	1.3	-2.1	1.6
Birth weight of first child	0.8	1.4	5.0	-1.1	-2.2	-1.0	-1.3	-0.6	0.4	-1.3	0.0	-0.3	1.9	0.3
Peak expiratory flow (PEF)	2.1	4.8	8.4	-2.3	-2.9	-1.9	-2.6	-1.6	1.6	-2.4	-2.7	-1.5	2.6	-1.0
Pulse wave reflection index	1.8	2.2	3.4	1.6	1.8	1.3	1.5	1.7	-1.2	1.7	1.4	1.0	0.3	1.9
Ever highly irritable/argumentative for 2 days	0.8	0.9	2.4	-1.2	-0.9	-0.3	-0.5	-0.4	1.5	-1.2	-1.6	-0.6	-0.3	-1.1
Loud music exposure frequency	0.8	0.9	1.9	1.1	1.2	0.9	1.2	0.9	-0.5	1.2	-0.2	1.4	-0.2	0.6
Qualifications: O levels/GCSEs or equivalent	2.1	3.3	7.2	-1.8	-1.5	-2.5	-2.0	-2.7	1.6	-1.8	-1.6	-1.6	-0.0	-1.7
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	3.5	1.3	1.3	0.5	1.1	1.2	-1.1	1.7	1.0	0.3	-1.4	1.9
Blood clot in the leg (DVT)	0.9	1.2	2.5	-1.4	-1.2	-0.2	-1.0	-1.0	1.4	-1.0	-1.6	-1.0	-0.4	-0.9
Medication: Paracetamol	0.3	0.5	1.5	0.5	0.9	1.1	0.8	0.1	-0.6	0.1	-0.7	0.9	-1.2	0.0
Headache pain in last month	0.4	0.8	2.9	-0.6	-0.6	-1.3	-0.7	-0.8	-0.0	-1.7	-1.0	0.2	-0.4	-0.8
Medication for cholesterol, blood pressure or diabetes	4.0	6.7	11.8	3.3	2.2	1.7	3.4	2.8	-2.7	2.8	1.7	2.8	-1.7	2.4
Glaucoma (self-reported)	0.5	0.6	1.3	-0.9	-0.4	-0.9	-0.9	-0.9	1.0	-0.5	0.0	-1.1	-0.9	-0.3
Gout (self-reported)	0.4	0.6	1.3	0.7	-0.2	0.2	0.3	1.1	-1.2	0.6	1.1	0.3	1.1	0.5
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.5	-0.7	-0.6	-1.1	-1.0	-1.1	0.4	-0.7	-0.9	-1.0	0.4	-1.2
Medication: Amlodipine	1.9	2.6	4.6	-1.9	-1.5	-0.6	-2.0	-2.1	1.2	-1.7	-1.0	-2.1	1.9	-1.1
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.5	-0.6	-0.3	0.2	-0.8	-1.0	0.9	-0.7	-0.6	-0.7	-1.0	-1.2
Birth weight	1.7	3.7	5.5	-2.0	-1.9	-2.0	-2.3	-1.6	2.0	-2.1	-2.1	-1.4	0.8	-2.2
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.7	-0.1	0.8	-0.4	0.1	0.4	0.8	0.1	0.4	0.2	0.2	0.0
High blood pressure (siblings)	7.1	10.2	15.4	-3.9	-3.5	-2.0	-3.8	-3.2	3.6	-3.2	-2.4	-3.8	1.0	-3.3
Forced vital capacity (FVC), Best measure	0.2	0.7	2.2	-0.6	-0.6	-0.7	-0.6	-1.0	1.0	-1.0	-1.5	-0.6	-0.2	-0.3
Body fat percentage	2.2	8.8	13.6	-3.6	-2.8	-3.4	-3.7	-2.5	3.1	-3.1	-2.2	-2.9	2.4	-2.4
Leg fat percentage (right)	1.6	5.7	8.6	-2.9	-2.5	-2.8	-2.9	-1.8	2.5	-2.4	-1.6	-2.4	2.4	-1.4
Arm fat-free mass (right)	5.9	30.5	45.8	-6.0	-6.3	-4.7	-6.8	-5.8	5.5	-6.0	-5.7	-4.6	3.3	-5.4
Exposure to tobacco smoke outside home	0.6	0.8	2.9	-0.8	0.6	-0.0	-0.5	-1.5	0.5	-0.6	-1.0	-1.0	-1.7	-0.0
Comparative body size at age 10	1.0	2.9	5.7	-1.9	-1.4	-1.3	-1.6	-2.1	1.4	-2.0	-2.4	-0.8	0.0	-2.3
Number of full brothers	1.2	1.5	2.9	-1.3	-1.2	-0.9	-1.5	-0.9	1.1	-1.6	-1.7	-0.6	0.1	-1.6
Worry too long after embarrassment	1.9	3.1	6.2	2.1	2.0	0.9	2.0	1.2	-1.5	2.5	1.7	1.0	-1.9	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.6	0.8	0.5	0.1	0.7	0.2	-0.8	0.5	0.9	0.3	-1.3	0.5
Wheeze or whistling in the chest in last year	3.0	5.3	8.8	-3.0	-2.9	-1.6	-2.5	-1.5	2.9	-2.4	-2.3	-1.4	2.6	-1.3
Number of children fathered	0.4	0.4	1.8	-0.7	-0.7	-0.1	-0.4	-0.2	1.3	-0.4	-0.7	-1.1	-0.1	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	3.4	-1.4	-1.2	-1.3	-0.8	-1.2	1.2	-1.8	-1.6	-1.3	-1.1	-1.5
Age at first live birth	1.7	3.1	9.6	-1.4	-1.3	-2.0	-1.9	-3.1	0.5	-1.9	-2.1	-0.8	0.4	-2.0
Pulse wave peak to peak time	0.7	0.8	2.5	-0.5	-0.3	-0.9	-0.8	-0.9	0.5	-0.8	-0.9	-0.5	-1.3	-1.6
Health satisfaction	1.8	2.3	4.8	-1.7	-1.4	-0.3	-1.5	-1.8	2.1	-1.4	-1.7	-1.0	0.3	-2.2
Shortness of breath walking on level ground	12.2	14.5	22.2	-4.5	-3.3	-2.7	-4.7	-4.3	4.4	-4.0	-4.1	-3.5	1.6	-3.6
Qualifications: College or University degree	1.8	5.6	13.3	-2.2	-2.5	-1.9	-2.7	-3.6	1.9	-3.0	-2.5	-1.8	-0.6	-2.0
Eye problems/disorders: None of the above	0.9	1.1	3.8	-0.8	-0.5	-1.3	-0.8	-0.7	-0.1	-1.6	-0.9	0.6	1.9	-1.0
Mouth/teeth dental problems: Loose teeth	1.2	1.4	3.6	-1.3	-1.6	-0.7	-1.5	-0.9	0.3	-1.9	-1.1	-0.2	1.5	-1.0
Emphysema/chronic bronchitis	0.0	0.1	0.2	0.1	-0.1	0.3	-0.1	0.2	-0.3	-0.0	0.2	0.0	0.1	0.5
Medication for pain relief, constipation, heartburn	0.6	0.9	2.6	1.2	1.0	0.8	1.0	0.9	-1.0	1.1	1.6	0.7	-0.4	0.4
Neck or shoulder pain in last month	0.9	1.3	2.8	-1.3	-1.3	-1.7	-1.0	-0.4	1.5	-1.3	-0.9	-0.6	0.6	-1.2
Medication: Blood pressure	2.2	3.8	7.2	-2.7	-1.6	-1.4	-2.5	-2.2	2.0	-2.2	-0.8	-2.1	1.7	-1.6
Angina (self-reported)	2.3	3.0	5.1	-2.0	-2.2	-1.1	-2.2	-1.1	2.2	-1.3	-1.8	-1.3	1.6	-1.6
Migraine (self-reported)	1.6	1.9	4.0	1.4	0.6	1.6	1.6	2.0	-1.3	1.4	1.1	1.9	0.3	1.0
Medication: Ibuprofen	0.6	0.7	3.6	-0.0	-1.0	-0.3	-0.0	0.7	-0.4	-0.7	-0.9	1.9	0.9	-0.0
Medication: Allopurinol	0.8	1.0	3.8	0.8	-0.1	0.2	0.3	1.2	-0.8	0.9	1.6	0.5	1.9	0.9
Medication: Omeprazole	0.3	0.3	0.8	0.5	0.6	-0.4	0.1	0.6	-0.7	0.5	0.9	-0.6	0.8	0.0
Medication: Seretide 50 evohaler	0.9	1.0	1.6	-1.2	-0.2	-0.4	-1.2	-1.2	1.3	-1.1	-0.8	-1.3	-1.0	-0.7
Mean time to correctly identify matches	1.6	3.1	5.7	1.8	1.8	2.4	2.1	1.3	-1.6	1.7	2.0	1.9	-1.3	0.8
Heart disease (mother)	4.4	5.4	8.4	-2.9	-2.5	-2.6	-2.6	-2.1	2.7	-2.5	-1.4	-2.1	1.6	-2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	4.8	-0.6	-1.0	-2.2	-0.7	-0.2	0.8	-0.3	0.1	-0.1	0.3	-0.9
Whole body fat mass	4.3	18.1	27.8	-5.0	-4.4	-4.4	-5.3	-4.0	4.4	-4.5	-3.8	-4.0	3.0	-3.7
Leg fat mass (right)	4.3	16.6	25.2	-4.8	-4.2	-4.2	-5.0	-3.9	4.3	-4.2	-3.6	-3.9	2.9	-3.3
Arm predicted mass (right)	5.3	26.9	40.3	-5.6	-5.8	-4.4	-6.3	-5.4	5.2	-5.6	-5.4	-4.3	2.9	-5.1
Pulse rate, automated reading	0.2	0.5	1.2	0.7	0.5	-0.5	1.1	-0.2	-0.7	0.9	0.7	0.0	-1.1	0.8
Alcohol intake frequency.	0.2	0.4	1.3	0.6	1.2	0.3	0.5	0.8	0.0	1.0	0.6	0.6	-0.2	0.3
Comparative height size at age 10	3.0	16.3	26.1	-4.4	-4.0	-2.8	-4.9	-5.1	3.9	-4.7	-3.6	-3.5	2.1	-4.3
Number of full sisters	1.1	1.4	4.2	-1.7	-1.0	-0.7	-0.9	-1.1	2.1	-1.0	-1.5	-0.8	0.6	-0.5
Suffer from ‘nerves’	2.0	3.2	5.3	2.1	2.3	1.1	2.2	1.2	-1.9	1.5	1.2	2.1	-2.0	1.2
Overall health rating	0.6	1.3	2.4	-1.4	-0.6	-0.7	-1.2	-1.5	1.4	-0.9	-1.2	-1.6	-0.1	-0.8
Chest pain or discomfort	9.2	13.3	20.3	-4.4	-4.1	-3.4	-4.5	-3.1	4.1	-3.6	-3.8	-3.5	2.3	-2.4
Had major operations	0.5	0.6	2.3	0.9	-0.0	1.1	0.5	0.6	-0.3	0.8	0.2	1.5	1.0	0.7
Age at last live birth	1.1	1.5	5.7	-1.2	-0.8	-1.7	-1.1	-2.4	0.7	-1.3	-1.2	-0.8	-0.2	-0.9
Family relationship satisfaction	0.1	0.1	0.7	-0.4	0.0	0.3	-0.0	-0.2	0.9	-0.4	-0.2	-0.2	-0.4	-0.2
Leg pain on walking	0.3	0.4	2.1	-0.6	0.0	-1.5	-0.3	-0.8	0.4	-0.2	-0.3	-0.6	-0.5	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.7	-0.4	-1.3	-1.2	0.3	0.3	0.7	-0.4	-0.2	-0.6	-0.0	0.6
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.9	0.0	-0.1	-0.8	-0.5	0.1	0.2	0.4	0.8	-0.0	0.9	0.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.5	0.4	0.6	0.6	0.7	0.1	-0.5	0.6	0.3	0.5	-0.3	0.7
Medication: Aspirin	0.6	0.8	2.4	-1.1	-1.3	0.2	-0.8	-0.4	1.1	-0.4	-1.0	-1.6	0.5	0.3
Supplements: Vitamin C	3.3	3.9	7.3	2.0	1.8	2.5	2.5	1.7	-0.9	2.7	1.8	1.4	-2.0	1.5
Knee pain experienced in last month	5.3	8.2	14.8	-3.3	-3.2	-3.8	-2.7	-2.8	2.9	-3.2	-3.0	-2.5	1.1	-2.0
Hypertension (Self-reported)	3.1	8.6	13.9	-3.6	-2.7	-2.9	-3.7	-3.5	2.8	-3.1	-1.8	-3.0	1.2	-2.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	3.3	-0.9	-0.9	-0.2	-1.4	-0.0	0.0	-1.3	-0.7	-0.4	1.8	-0.4
Illnesses of father: Heart disease	0.2	0.2	0.8	-0.4	-0.5	-0.6	-0.4	-0.2	0.9	0.0	0.4	-0.8	-0.4	-0.3
Illnesses of siblings: Diabetes	4.7	5.8	10.7	-2.5	-2.5	-2.1	-3.3	-2.4	2.0	-2.5	-2.0	-2.7	1.4	-2.6
Smoking status: Previous	0.8	1.1	4.2	0.9	0.2	2.1	0.5	1.3	-0.7	0.9	1.0	1.5	0.6	0.8
Forced expiratory volume in 1-second (FEV1), predicted	3.0	6.1	19.1	-2.1	-2.4	-1.8	-2.3	-4.4	2.1	-1.9	-3.0	-2.5	-1.8	-1.8
Whole body fat-free mass	6.2	35.7	52.1	-6.5	-6.6	-5.4	-7.2	-6.3	6.2	-6.3	-6.3	-5.0	3.4	-5.8
Leg fat-free mass (right)	5.2	27.9	41.6	-5.8	-5.7	-5.1	-6.5	-5.3	5.4	-5.6	-5.4	-4.2	3.2	-5.2
Arm fat percentage (left)	1.8	7.2	11.7	-3.2	-2.6	-3.3	-3.4	-2.0	2.7	-2.7	-2.0	-2.3	2.4	-2.4
Average weekly red wine intake	6.2	9.2	15.6	-3.0	-3.0	-3.4	-3.5	-3.9	2.2	-3.3	-3.3	-1.8	0.7	-3.7
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.1	0.5	0.6	0.1	0.8	1.4	0.4	1.0	0.9	0.2	0.2	1.2
Mood swings	0.7	1.3	4.2	1.1	2.0	0.4	1.1	1.0	-0.9	1.3	1.1	0.7	-0.1	1.5
Loneliness, isolation	0.2	0.3	1.4	-0.0	1.0	0.4	-0.3	-0.7	0.1	-0.4	-0.2	0.0	-1.2	-0.7
Long-standing illness, disability or infirmity	2.4	3.6	6.0	-2.3	-1.0	-1.6	-2.5	-2.3	2.4	-2.0	-1.1	-2.4	0.3	-1.9
Ever had bowel cancer screening	0.1	0.1	0.4	-0.3	-0.1	-0.3	-0.0	-0.2	0.5	-0.3	-0.2	-0.0	0.7	0.6
Diabetes diagnosed by doctor	1.7	2.8	5.6	-2.1	-1.5	-0.9	-2.1	-1.7	2.4	-1.3	-1.6	-1.8	0.5	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.8	-0.3	-0.6	0.1	-0.1	0.5	0.0	-0.9	-0.0	-0.1	0.2	-0.7
Friendships satisfaction	1.3	1.6	3.8	-1.2	-1.0	-0.3	-1.0	-1.7	1.9	-0.8	-0.9	-1.2	-1.2	-1.9
Qualifications: nursing, teaching	1.5	2.4	7.0	-1.4	-0.3	-1.0	-1.6	-2.3	1.6	-1.7	-2.6	-0.8	-0.8	-1.4
Commuting to job workplace: Walk	0.4	0.5	2.6	0.4	0.3	-1.1	0.5	-0.1	-0.4	0.1	-0.4	0.2	-1.6	-0.7
Eye problems/disorders: Cataract	1.2	1.4	3.6	0.9	1.0	1.1	0.9	1.4	-0.2	1.7	1.9	-0.6	-1.1	1.4
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.7	0.1	0.6	0.4	0.3	0.9	0.1	0.3	-0.2	0.9	-0.1	0.3
Medication for cholesterol	0.6	0.9	3.0	1.2	0.6	1.0	1.1	0.7	-1.3	0.5	0.6	1.7	-0.2	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.4	-1.0	0.4	-0.4	-0.8	-0.9	1.1	-1.0	-1.2	-0.3	0.3	-0.9
Back pain experienced in last month	3.0	4.4	7.7	-2.2	-1.7	-1.7	-2.4	-2.6	1.5	-2.8	-2.0	-2.0	-1.5	-2.2
Mineral and other dietary supplements	0.2	0.3	1.2	0.6	-0.1	-0.5	-0.0	0.7	-1.1	0.1	-0.1	0.9	0.5	-0.0
Breast cancer (self-reported)	2.3	2.8	10.3	1.5	2.5	1.5	1.1	0.0	-1.3	1.6	1.8	-0.3	-3.2	0.8
Asthma (self-reported)	0.4	0.7	5.4	-0.1	0.4	0.7	0.2	-0.8	0.1	-0.1	-0.1	-0.8	-2.3	-0.9
Osteoporosis (self-reported)	0.7	0.9	1.9	1.1	1.4	1.2	1.0	0.2	-0.9	1.1	1.0	1.0	-0.6	0.2
Osteoarthritis (self-reported)	0.1	0.1	0.9	-0.4	0.0	0.3	-0.2	-0.6	0.3	-0.1	-0.9	0.2	0.0	0.1
Medication: Aspirin	1.7	2.2	5.4	-1.9	-1.7	-0.6	-1.6	-1.2	1.8	-1.2	-1.7	-2.3	0.9	-0.2
Medication: Gliclazide	0.3	0.3	0.8	0.3	0.5	0.6	0.1	0.1	0.5	0.2	-0.8	0.9	-0.8	-0.6
Illnesses of father: None of the above (group 1)	0.8	1.0	1.9	1.0	1.4	1.4	1.2	0.7	-1.1	0.9	0.0	0.4	-1.4	0.8
Smoking status: Current	1.0	1.6	3.4	1.1	0.1	0.8	1.3	1.8	-1.2	1.2	1.2	1.8	1.2	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	5.6	1.5	2.4	2.0	1.5	1.0	-1.4	1.7	0.9	0.9	-1.9	1.1
Whole body water mass	6.0	34.2	50.1	-6.3	-6.5	-5.3	-7.1	-6.2	6.0	-6.2	-6.2	-4.8	3.3	-5.7
Leg predicted mass (right)	5.2	27.6	41.1	-5.7	-5.6	-5.1	-6.4	-5.3	5.4	-5.6	-5.4	-4.2	3.2	-5.2
Arm fat mass (left)	3.9	16.1	25.5	-4.6	-4.3	-4.3	-5.1	-3.5	4.1	-4.2	-3.5	-3.5	3.0	-3.7
Number of self-reported non-cancer illnesses	2.8	4.9	9.4	-2.5	-1.8	-1.9	-2.8	-3.1	1.8	-2.3	-1.3	-2.6	0.5	-2.2
Average weekly champagne plus white wine intake	1.4	1.9	6.9	1.4	1.1	1.2	1.7	1.7	-1.0	1.0	0.8	2.6	0.8	0.8
Miserableness	0.5	0.9	2.7	-1.4	-0.3	-1.1	-0.8	-0.7	1.6	-0.7	-0.8	-1.0	0.6	-0.1
Guilty feelings	0.8	1.2	3.2	1.0	1.8	-0.0	1.1	0.3	-1.0	0.9	1.2	1.8	-0.2	0.9
Wears glasses or contact lenses	0.1	0.1	0.5	-0.2	0.1	0.4	-0.2	-0.6	0.1	-0.3	-0.1	-0.7	0.1	-0.0
Ever taken oral contraceptive pill	4.6	5.1	8.1	2.6	2.0	1.9	2.4	2.6	-2.0	2.8	2.2	2.3	0.2	2.6
Hearing aid user	2.4	2.7	4.4	1.7	2.0	1.8	2.0	1.3	-1.7	1.6	1.2	1.6	-2.1	0.2
Mother’s age at death	0.3	0.4	0.9	0.6	0.7	0.9	0.4	0.7	-0.7	0.6	0.7	0.9	0.3	0.3
Financial situation satisfaction	1.3	1.6	3.8	-1.4	-1.5	-0.2	-1.2	-1.7	1.9	-0.9	-1.2	-1.1	-0.3	-1.3
Tinnitus: Yes, now most or all of the time	0.2	0.2	1.0	0.2	-0.2	1.0	0.2	0.3	-0.4	0.3	0.6	0.5	-0.0	-0.2
Commuting to job workplace: Public transport	1.4	1.7	2.6	1.2	1.6	1.6	1.5	1.2	-1.3	0.9	1.4	1.1	-0.8	1.5
Eye problems/disorders: Glaucoma	1.2	1.5	3.0	-1.4	-0.5	-1.5	-1.1	-1.3	1.7	-1.0	-0.8	-1.6	-1.2	-0.7
Medication: Blood pressure	0.6	1.1	3.6	-1.2	-0.6	-0.8	-1.3	-1.3	1.2	-0.5	-0.9	-1.9	-0.1	-0.2
Pain type(s) experienced in last month: Hip pain	7.9	10.0	14.2	-3.6	-3.2	-3.1	-3.2	-3.0	3.3	-3.6	-3.7	-2.0	1.6	-3.8
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.6	0.4	1.0	1.3	0.5	-0.1	0.3	0.9	1.2	-0.9	-0.7	1.1
High cholesterol (Self-reported)	5.1	9.1	14.1	-3.8	-3.0	-2.6	-3.5	-3.0	3.6	-3.3	-3.0	-3.0	0.8	-2.5
Medication: Bendroflumethiazide	0.2	0.2	1.6	0.0	-0.3	0.2	-0.1	0.1	-0.3	0.2	1.3	-0.7	0.2	0.5
Medication: Paracetamol	0.2	0.3	1.0	0.2	0.3	0.7	0.5	-0.0	-0.3	-0.1	-0.8	0.7	-1.0	-0.4
Medication: Lisinopril	0.6	0.8	1.6	-0.7	0.6	-0.5	-0.8	-1.3	0.3	-1.3	-1.2	-1.1	-0.6	-0.7
Medication: Atorvastatin	2.1	2.6	6.4	-1.9	-1.6	-1.8	-1.7	-1.2	2.5	-0.8	-1.2	-2.4	-0.2	0.1
Illnesses of father: High blood pressure	1.2	1.5	5.0	-1.1	-1.6	-2.2	-1.1	-1.3	1.1	-1.1	-0.2	-0.7	1.1	-1.1
Alcohol drinker status: Never	0.1	0.1	0.3	-0.5	-0.3	-0.4	-0.5	-0.2	0.5	-0.2	-0.3	-0.1	0.3	-0.1
Ever smoked	1.6	2.7	6.0	1.6	0.7	2.3	1.3	2.1	-1.3	2.0	1.4	2.4	0.5	1.3
Basal metabolic rate	6.4	35.4	52.4	-6.5	-6.5	-5.5	-7.2	-6.2	6.1	-6.3	-6.1	-5.0	3.5	-5.7
Leg fat percentage (left)	1.2	4.3	6.7	-2.6	-2.3	-2.5	-2.6	-1.3	2.2	-2.1	-1.2	-2.1	2.2	-1.2
Arm fat-free mass (left)	6.4	32.4	47.9	-6.3	-6.4	-4.9	-6.9	-5.8	5.9	-6.1	-5.9	-5.0	3.3	-5.3
Number of operations (self-reported)	0.1	0.1	0.4	0.0	-0.7	0.4	-0.5	-0.0	-0.5	-0.2	0.4	-0.4	0.1	-0.2
Average weekly beer plus cider intake	0.2	0.4	2.1	-0.6	-0.6	-0.1	-0.2	-0.1	0.8	0.3	0.0	-0.4	1.5	0.5
Irritability	2.2	3.7	6.4	2.2	1.5	1.5	1.9	2.5	-2.1	2.1	2.1	1.8	-0.2	2.1
Risk taking	0.2	0.3	0.7	-0.5	-0.8	-0.7	-0.5	-0.3	0.7	-0.1	0.2	-0.2	-0.8	-0.8
Ever had prostate specific antigen (PSA) test	1.7	1.9	4.5	1.7	1.3	1.6	1.3	1.0	-1.8	1.2	1.5	2.1	-0.2	-0.3
Fractured/broken bones in last 5 years	1.1	1.5	2.3	-1.2	-1.3	-1.5	-1.5	-1.0	1.4	-1.1	-1.3	-0.7	0.7	-1.2
Age started oral contraceptive pill	0.2	0.3	1.4	0.0	0.9	0.3	-0.2	-0.2	0.1	0.6	0.7	-0.2	-1.2	-0.3
Diastolic blood pressure, automated reading	6.9	21.4	29.4	-5.4	-3.9	-4.6	-5.4	-5.2	4.9	-4.7	-4.2	-5.3	2.7	-3.8
Ever depressed for a whole week	0.3	0.4	1.2	0.7	0.6	0.7	0.2	0.9	-1.1	-0.0	0.5	0.9	0.0	0.4
Unable to work because of sickness or disability	0.4	0.6	3.2	0.5	0.8	1.8	0.4	-0.2	-0.4	0.4	-0.4	1.0	-0.7	0.1
Commuting to job workplace: Cycle	0.2	0.3	0.9	-0.1	-0.2	-0.5	0.4	0.5	0.8	0.1	-0.4	1.0	0.2	-0.7
Myopia	1.6	2.3	4.7	-1.5	-1.1	-2.1	-1.5	-1.9	1.3	-2.2	-1.2	-0.9	-0.4	-1.6
Vascular/heart problems diagnosed by doctor	2.7	7.3	11.9	3.3	2.5	2.6	3.5	3.1	-2.7	2.8	1.8	2.9	-1.0	2.7
Cholesterol lowering medication	3.2	4.7	8.1	-2.6	-1.8	-2.8	-2.2	-2.2	2.9	-1.8	-2.2	-2.7	0.3	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.8	0.2	0.4	-0.4	-0.2	0.7	-0.6	0.2	0.6	-0.5	1.3	-0.2
Pain experienced in last month	7.0	11.7	17.9	3.8	3.5	3.9	4.0	3.5	-3.2	4.2	3.4	3.1	-0.3	3.1
Supplements: Calcium	0.2	0.2	1.4	-0.0	0.9	-0.4	-0.1	-1.2	-0.0	-0.0	-0.4	0.2	0.1	-0.4
Basal cell carcinoma (self-reported)	0.2	0.3	0.6	0.4	0.5	0.7	0.5	0.6	-0.8	0.4	0.4	0.3	-0.4	0.5
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.3	-0.1	0.5	0.8	0.1	1.1	0.1	0.3	0.1	-0.4	0.6	0.5
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	2.4	-1.3	-1.0	-0.1	-1.1	-1.0	1.3	-0.9	-1.6	-1.0	-0.4	-1.0
Heart disease (siblings)	0.7	0.8	3.0	-1.1	-1.3	-0.4	-0.8	-0.3	0.5	-0.7	-0.5	-1.1	1.7	0.1
Alcohol drinker status: Previous	2.1	2.4	4.4	-1.9	-1.6	-0.6	-2.1	-1.3	1.7	-1.7	-1.7	-1.4	0.5	-1.6
Pack years of smoking	0.6	1.0	3.4	-0.8	-1.2	-0.6	-1.0	0.1	0.2	-1.0	-0.8	-0.6	1.9	-1.2
Impedance of whole body	0.5	2.8	4.9	1.7	1.9	1.5	2.2	0.6	-1.9	1.4	1.8	0.7	-2.0	1.8
Leg fat mass (left)	3.8	14.8	22.7	-4.6	-4.0	-3.9	-4.8	-3.6	4.1	-4.0	-3.3	-3.6	2.7	-3.1
Arm predicted mass (left)	6.0	30.6	45.4	-6.1	-6.1	-4.8	-6.7	-5.7	5.8	-5.9	-5.9	-4.8	3.1	-5.1