Hub : Genes

PRRG2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Liver	0.229	0.086	2.4e-03	0.097	NA	0.066	NA	0.121	1.1e-03	NA	6.7e-03	NA	3.1e-04
2	GTEx	Skin Sun Exposed Lower leg	0.235	0.051	1.6e-09	0.181	NA	0.201	NA	0.214	6.9e-15	NA	1.5e-16	NA	1.3e-17
3	TCGA	Colon Adenocarcinoma	0.052	0.037	6.9e-03	0.049	0.000	-0.004	NA	0.022	8.0e-04	0.30000	7.4e-01	NA	1.9e-02
4	TCGA	Kidney Renal Papillary Cell Carcinoma	0.056	0.033	4.8e-04	0.095	0.054	0.082	NA	0.086	4.3e-06	0.00048	2.1e-05	NA	1.3e-05
5	TCGA	Testicular Germ Cell Tumors	0.106	0.064	3.7e-03	0.090	0.036	0.054	NA	0.058	4.4e-04	0.02100	5.7e-03	NA	4.1e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.2	1.9	3.0	-1.6	-1.3	1.5	-1.7	0.0
Bipolar Disorder or Schizophrenia	7.5	18.4	21.3	-4.2	-3.9	4.1	-4.6	-4.5
Depressed Affect (Nagel 2018)	0.3	0.7	0.9	0.9	0.8	-1.0	0.7	0.7
Depression (Nagel 2018)	0.9	1.3	2.1	-0.9	-1.0	0.9	-1.4	-1.4
Intelligence (Savage-Jansen 2018)	4.9	15.1	17.2	3.7	3.9	-3.7	4.2	4.0
Neuroticism (Nagel 2018)	1.3	3.0	3.6	1.6	1.7	-1.6	1.9	1.8
Schizophrenia (2018)	7.5	15.7	16.8	-4.1	-4.0	4.1	-4.0	-3.6
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Worry (Nagel 2018)	0.7	1.4	1.7	1.2	1.1	-1.1	1.3	1.2
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	-0.3	-0.5	0.3	-0.7	-0.6
Alzheimer’s Disease (in father)	3.6	3.9	5.3	-1.8	-1.9	1.8	-2.0	-2.3
Alzheimer’s Disease (including proxy)	2.0	2.9	3.7	-1.4	-1.9	1.4	-1.9	-1.8
Crohns Disease (2017)	2.8	6.1	7.8	2.3	2.2	-2.2	2.8	2.8
Irritable Bowel Disease (IBD)	3.1	7.3	10.6	2.2	2.6	-2.2	3.3	3.1
Ulcerative Colitis (UC)	1.5	2.9	4.7	1.2	1.8	-1.3	2.2	1.9
Major Depression (MDD)	0.1	0.1	0.2	0.0	0.5	-0.1	0.5	0.0
Reaction Time	0.2	0.4	0.8	0.9	0.5	-0.9	0.3	0.5
Verbal and Numeric Reasoning (VNR)	4.1	9.8	10.7	3.0	3.1	-3.1	3.3	3.2
Breast Cancer	0.1	0.3	0.4	-0.6	-0.2	0.6	-0.4	-0.6
Ovarian Cancer	1.1	1.5	2.5	-1.5	-1.5	1.6	-0.7	-0.4
Prostate Cancer	3.5	4.9	7.6	2.8	2.4	-2.7	1.6	1.1
Age at First Birth	0.1	0.1	0.5	0.7	0.1	-0.3	-0.2	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.2	1.6	4.5	-1.9	-2.1	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.5	0.8	1.1	1.0	1.0	-1.0	0.8	0.8
Mean Putamen Volume	1.0	1.2	1.8	0.9	0.9	-0.8	1.3	1.3
Fasting Glucose	1.1	1.3	1.9	-1.0	-1.4	1.0	-1.3	-1.0
HbA1C	0.2	0.3	0.7	-0.5	-0.3	0.4	-0.5	-0.8
HDL Cholesterol	0.3	0.5	0.9	0.5	0.4	-0.5	0.9	0.9
LDL Cholesterol	1.3	2.0	5.6	2.4	2.1	0.0	0.0	0.0
Lupus	4.8	7.2	9.8	-2.4	-2.4	2.3	-3.1	-3.1
Neuroticism (2016)	0.7	1.0	1.8	1.3	1.0	-1.3	0.7	0.6
Primary Biliary Cirrhosis	0.3	0.5	0.7	0.9	0.8	-0.8	0.5	0.2
Rheumatoid Arthritis	0.2	0.3	0.5	-0.7	-0.3	0.6	-0.6	-0.7
Schizophrenia (2014)	7.9	17.5	19.5	-4.1	-4.0	4.1	-4.4	-4.3
Triglycerides	1.7	2.7	7.6	2.8	2.4	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	1.1	1.7	2.4	1.0	1.5	-1.1	1.5	1.2
Blood Eosinophil Count	0.0	0.0	0.0	0.2	0.0	-0.1	-0.1	0.2
Blood Platelet Count	2.0	23.3	27.1	5.1	5.2	-5.0	4.7	4.1
Blood Red Count	12.9	124.8	136.9	11.7	11.5	-11.4	11.0	10.2
Blood White Count	0.3	2.4	3.2	1.4	1.2	-1.4	1.8	1.8
Heel T-Score	0.2	1.4	2.6	0.5	0.9	-0.7	1.6	1.6
BMI	0.0	0.0	0.1	0.2	0.2	-0.2	0.3	0.0
Height	2.5	48.2	59.4	7.7	7.3	-7.7	6.1	5.7
Waist Hip Ratio (WHR)	1.9	8.7	10.4	3.1	3.2	-2.9	3.0	2.5
Systolic Blood Pressure	0.3	1.7	2.9	-1.7	-1.7	1.6	-0.4	0.4
Smoking Status	0.5	1.2	2.1	1.4	1.2	-1.4	0.5	0.2
Allergy or Eczema	4.7	12.3	18.3	3.9	4.3	-3.8	3.0	2.1
Cardiovascular Disease	0.9	3.1	4.9	2.2	2.1	-2.2	1.0	0.7
Hypothyroidism (self reported)	6.2	14.4	19.8	-3.4	-3.6	3.3	-4.5	-4.1
Respiratory disease	0.5	1.1	2.2	1.2	1.5	-1.2	0.5	-0.1
Type 2 Diabetes (T2D) (2018)	1.5	2.8	4.4	2.1	2.0	-2.0	1.0	0.5
Lung FEV1/FVC ratio	0.3	1.8	2.2	-1.4	-1.3	1.2	-1.2	-1.5
Lung FVC	0.3	1.6	4.5	0.0	0.5	0.0	1.8	2.1
Neuroticism	1.3	3.2	3.8	1.7	1.6	-1.7	1.9	1.9
Chronotype (morning person)	0.0	0.1	0.2	-0.5	-0.2	0.5	-0.2	-0.2
Hair Pigment	0.0	1.0	1.7	-1.2	-0.9	1.3	-0.6	-0.8
Tanning	0.3	4.2	6.6	-1.8	-1.7	1.8	-2.3	-2.6
Hand grip strength (left)	2.9	7.7	8.5	-2.7	-2.9	2.8	-2.9	-2.5
Number of treatments/medications taken	0.1	0.3	0.6	0.7	0.4	-0.8	0.1	0.2
Average weekly spirits intake	0.4	0.5	1.7	-0.1	-0.0	0.1	-0.9	-1.3
Sensitivity / hurt feelings	1.0	1.7	2.0	1.4	1.2	-1.4	1.2	1.2
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.6	0.8	0.5	-0.7	0.3	0.3
Hearing difficulty/problems: Yes	0.9	1.3	1.7	1.0	1.3	-1.0	1.3	1.1
Relative age of first facial hair	0.3	0.6	1.1	-1.1	-0.5	1.1	-0.3	-0.3
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.6	0.6	0.6	-0.8	0.7	0.7
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.0	-0.1	-0.2	0.1	-0.2	-0.1
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	0.3	0.2	-0.5	-0.3	-0.2
Systolic blood pressure, automated reading	1.5	4.4	7.3	-2.6	-2.7	2.5	-1.2	-0.3
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	0.8	0.7	0.7	-0.7	-0.3	-0.9
Angina	1.0	1.3	2.9	1.6	0.9	-1.7	0.2	0.2
Medication for hormone replacement therapy	0.1	0.1	0.2	0.0	-0.2	-0.1	-0.4	-0.4
Vitamin and mineral supplements	1.4	2.0	3.6	1.9	1.3	-1.9	0.7	0.6
Supplements: Zinc	0.4	0.4	1.3	0.1	0.3	-0.1	-0.7	-1.1
Medication: Co-codamol	0.3	0.3	0.5	-0.7	-0.4	0.7	-0.5	-0.5
Medication: Metformin	1.8	2.5	3.2	1.7	1.8	-1.7	1.6	1.2
Diabetes (father)	2.8	3.5	4.0	1.9	2.0	-1.8	2.0	1.7
Diabetes (mother)	2.0	2.5	3.5	1.3	1.6	-1.2	1.9	1.8
Severe depression (siblings)	1.0	1.1	2.2	1.5	1.1	-1.5	0.1	-0.2
Pack years adult smoking proportion	0.1	0.2	0.3	0.6	0.4	-0.5	0.2	0.1
Impedance of leg (right)	0.0	0.2	0.6	0.2	0.3	-0.3	0.5	0.8
Leg fat-free mass (left)	2.0	10.7	13.6	3.7	3.4	-3.7	2.9	2.6
Trunk fat percentage	0.3	1.1	1.5	1.0	0.9	-1.0	1.2	1.2
Hand grip strength (right)	3.4	9.4	10.9	-3.2	-3.2	3.3	-2.9	-2.6
Townsend deprivation index at recruitment	1.3	1.8	2.0	1.3	1.4	-1.4	1.4	1.3
Current tobacco smoking	0.0	0.0	0.0	-0.0	-0.0	-0.0	-0.2	-0.2
Average weekly fortified wine intake	0.7	0.9	1.5	0.6	1.0	-0.6	1.2	1.0
Maternal smoking around birth	0.0	0.0	0.1	0.3	0.1	-0.2	0.1	0.2
Fed-up feelings	0.2	0.3	0.4	0.5	0.4	-0.5	0.6	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.4	0.2	-0.0	-0.2	-0.6	-0.6
Relative age voice broke	0.2	0.3	0.4	-0.6	-0.5	0.6	0.1	0.5
Taking other prescription medications	1.4	2.2	4.9	-1.0	-0.9	0.9	-1.9	-2.2
Age when periods started (menarche)	3.3	8.0	12.5	-3.5	-3.3	3.5	-1.8	-1.0
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.0	0.9	1.0	-0.9	0.2	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	5.4	0.9	1.3	-1.0	2.2	2.3
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.9	-0.5	-0.6	0.5	-0.9	-0.9
Qualifications: CSEs or equivalent	1.3	1.7	4.7	0.4	0.5	-0.3	1.8	2.2
Serious illness, injury or assault to yourself	0.0	0.0	0.1	0.0	-0.0	-0.1	0.2	0.3
High blood pressure	0.0	0.1	0.2	0.0	-0.2	-0.1	-0.4	-0.3
Hayfever, allergic rhinitis or eczema	2.8	6.1	10.5	2.8	3.2	-2.7	1.9	0.9
Multivitamins +/- minerals	1.4	1.8	3.4	-1.8	-1.2	1.8	-0.6	-0.7
Stomach or abdominal pain in last month	0.2	0.2	0.3	0.6	0.4	-0.5	-0.3	-0.4
Supplements: Glucosamine	1.3	1.7	2.0	-1.3	-1.1	1.3	-1.4	-1.4
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	2.8	-1.3	-1.2	1.2	-1.6	-1.7
Medication: Atenolol	0.4	0.6	1.5	0.6	0.1	-0.7	0.6	1.2
Medication: Levothyroxine sodium	5.1	8.7	9.9	-2.9	-3.0	2.8	-3.1	-2.7
Sitting height	5.2	36.8	48.7	6.9	6.1	-7.0	5.1	4.9
Chronic bronchitis/emphysema (father)	0.4	0.4	0.6	-0.6	-0.6	0.6	-0.7	-0.8
High blood pressure (mother)	0.3	0.4	0.9	-0.3	-0.5	0.2	-0.9	-0.9
Body mass index (BMI)	0.0	0.1	0.3	-0.3	-0.5	0.3	-0.2	-0.1
Impedance of leg (left)	0.0	0.0	0.1	-0.1	-0.0	0.1	0.1	0.4
Leg predicted mass (left)	2.1	10.9	13.8	3.7	3.4	-3.7	2.9	2.6
Trunk fat mass	0.7	3.0	3.4	1.8	1.7	-1.8	1.7	1.6
Waist circumference	0.8	3.0	3.4	1.8	1.6	-1.8	1.7	1.6
Number of incorrect matches in round	0.2	0.3	0.4	-0.6	-0.4	0.6	-0.4	-0.4
Past tobacco smoking	3.9	7.1	10.7	-3.3	-3.0	3.2	-1.9	-1.4
Alcohol usually taken with meals	0.6	1.0	1.4	1.1	1.2	-1.0	0.9	0.7
Nervous feelings	0.6	1.1	1.6	1.3	1.0	-1.3	0.9	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.6	1.1	1.2	-1.1	0.6	0.3
Hearing difficulty/problems with background noise	0.0	0.1	0.2	0.1	0.4	-0.2	0.4	0.3
Hair/balding pattern: Pattern 2	0.5	0.6	0.8	-0.9	-0.9	0.8	-0.7	-0.6
Had menopause	0.3	0.4	0.8	-0.3	-0.5	0.3	-0.8	-0.9
Had other major operations	1.7	2.1	5.1	-0.6	-0.8	0.6	-2.0	-2.3
Forced vital capacity (FVC)	1.8	6.9	7.9	2.6	2.8	-2.5	2.7	2.5
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	4.9	0.4	0.5	-0.5	1.8	2.2
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.1	1.5	1.3	-1.4	-0.0	-0.4
Qualifications: None of the above	0.9	2.0	2.7	-1.6	-1.6	1.6	-1.3	-0.9
Financial difficulties in last 2 years	0.3	0.4	0.6	0.5	0.8	-0.5	0.6	0.4
Mouth/teeth dental problems	0.4	0.5	0.7	0.9	0.7	-0.8	0.6	0.7
Heart attack	0.3	0.4	0.8	0.6	0.4	-0.6	0.6	0.9
Allergy	4.0	9.2	14.8	-3.5	-3.8	3.5	-2.3	-1.4
Pain all over the body in last month	0.2	0.2	0.5	0.0	0.2	-0.1	-0.5	-0.7
Diabetes (self-reported)	0.2	0.3	0.9	0.2	0.4	-0.2	-0.5	-0.9
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.9	1.2	1.7	-1.2	0.9	0.2
Medication: Ramipril	2.8	3.5	5.5	2.3	1.9	-2.4	1.2	1.2
Medication: Simvastatin	3.0	4.5	7.8	2.8	2.4	-2.8	1.0	0.6
Fluid intelligence score	3.6	7.5	8.2	2.8	2.8	-2.7	2.9	2.5
Illnesses of siblings	0.2	0.3	0.7	0.6	0.5	-0.4	-0.4	-0.8
Neuroticism score	0.3	0.6	0.9	0.8	0.6	-0.7	0.9	1.0
Weight	1.3	6.6	8.4	2.9	2.4	-2.9	2.3	2.3
Impedance of arm (right)	1.5	6.8	9.4	2.2	2.5	-2.1	3.1	3.0
Arm fat percentage (right)	0.1	0.4	0.7	0.5	0.4	-0.5	0.8	0.8
Trunk fat-free mass	1.7	9.9	14.0	3.7	3.2	-3.7	2.5	2.3
Hip circumference	0.5	2.3	2.9	1.6	1.2	-1.6	1.5	1.7
Time employed in main current job	0.3	0.4	0.8	-0.1	-0.7	0.2	-0.9	-0.8
Alcohol intake versus 10 years previously	0.4	0.5	1.6	-0.5	-0.3	0.4	0.7	1.2
Father’s age at death	0.3	0.3	0.5	-0.5	-0.5	0.5	-0.7	-0.7
Worrier / anxious feelings	3.1	5.9	7.9	2.6	2.8	-2.6	2.2	1.6
Frequency of tiredness / lethargy in last 2 weeks	6.9	11.2	18.1	4.2	3.7	-4.2	2.0	1.5
Falls in the last year	0.1	0.1	0.2	0.4	0.1	-0.4	-0.3	-0.4
Hair/balding pattern: Pattern 3	2.3	3.5	4.1	1.7	1.8	-1.8	2.0	2.0
Number of live births	0.1	0.2	0.3	0.6	0.6	-0.5	-0.1	-0.3
Forced expiratory volume in 1-second (FEV1)	1.0	3.4	4.0	1.8	2.0	-1.7	2.0	1.8
Pulse rate	0.1	0.1	0.3	0.2	-0.6	-0.1	0.1	0.6
Happiness	1.6	1.9	3.3	1.8	1.7	-1.8	0.5	-0.2
Noisy workplace	0.1	0.1	0.2	0.4	0.2	-0.4	-0.4	-0.4
Qualifications: A levels/AS levels or equivalent	2.8	6.2	10.2	2.9	3.2	-2.9	1.8	1.0
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	1.7	1.1	1.1	-1.1	1.3	1.0
Mouth/teeth dental problems: Dentures	1.2	2.0	3.1	1.1	1.3	-1.2	1.7	1.8
Asthma	0.6	1.2	1.9	1.3	1.4	-1.3	0.7	0.2
Medication: Ibuprofen (e.g. Nurofen)	2.3	2.9	3.6	1.6	1.6	-1.6	1.9	1.7
Medication: Cholesterol lowering	0.5	0.8	1.3	1.1	0.6	-1.2	-0.5	-0.7
Depression (self-reported)	0.0	0.0	0.1	0.1	0.0	-0.1	-0.1	-0.2
Medication: Lansoprazole	1.0	1.1	2.0	-1.0	-1.4	1.0	-1.1	-0.7
Prospective memory result	4.6	5.7	7.0	-2.6	-2.6	2.6	-2.2	-1.8
Lung cancer (father)	0.0	0.0	0.0	-0.1	-0.0	0.2	0.1	0.1
Illnesses of mother	3.1	3.8	5.5	1.7	2.3	-1.6	2.3	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	3.6	1.6	1.8	-1.6	1.9	1.7
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	-0.6	-0.5	0.7	-0.2	-0.1
Impedance of arm (left)	0.6	3.0	5.0	1.2	1.5	-1.0	2.2	2.2
Arm fat mass (right)	0.3	1.4	1.7	1.3	1.1	-1.3	1.2	1.1
Trunk predicted mass	1.7	9.8	13.9	3.7	3.2	-3.7	2.5	2.2
Standing height	3.7	37.1	45.3	6.7	6.2	-6.7	5.4	5.2
Length of working week for main job	0.0	0.1	0.1	0.2	-0.1	-0.2	-0.4	-0.2
Exposure to tobacco smoke at home	0.2	0.2	0.3	0.6	0.2	-0.5	-0.5	-0.5
Breastfed as a baby	0.4	0.5	0.9	0.5	0.6	-0.5	1.0	0.9
Tense / ‘highly strung’	0.6	1.0	1.6	-0.8	-1.2	0.7	-1.3	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.6	-0.5	-0.8	0.4	-0.8	-0.4
Hair/balding pattern: Pattern 4	1.0	2.5	3.5	1.6	1.2	-1.5	1.6	1.9
Birth weight of first child	2.7	4.9	7.6	-2.0	-1.7	2.1	-2.3	-2.8
Peak expiratory flow (PEF)	1.5	3.6	5.0	2.0	2.2	-2.0	1.8	1.4
Pulse wave reflection index	0.5	0.6	1.3	0.9	1.2	-0.8	0.3	-0.2
Ever highly irritable/argumentative for 2 days	2.1	2.5	3.7	1.7	1.9	-1.7	1.5	1.0
Loud music exposure frequency	0.2	0.2	0.3	0.6	0.6	-0.4	0.2	0.1
Qualifications: O levels/GCSEs or equivalent	1.8	2.8	4.6	1.9	2.1	-1.9	1.4	0.8
Mouth/teeth dental problems: Bleeding gums	0.0	0.1	0.1	-0.2	-0.3	0.2	0.0	0.2
Blood clot in the leg (DVT)	2.2	2.8	4.2	2.0	2.0	-2.0	1.2	0.8
Medication: Paracetamol	1.1	1.8	2.9	-1.1	-1.4	1.0	-1.7	-1.5
Headache pain in last month	1.5	2.6	5.3	2.3	1.7	-2.2	0.1	-0.2
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.8	0.3	0.7	-0.3	1.6	1.7
Glaucoma (self-reported)	1.8	2.1	2.4	-1.4	-1.6	1.5	-1.4	-1.3
Gout (self-reported)	0.3	0.4	1.3	-0.3	-0.2	0.3	-0.9	-1.1
Hypothyroidism/myxoedema (self-reported)	7.8	15.2	18.5	-3.8	-3.7	3.6	-4.3	-4.1
Medication: Amlodipine	1.4	1.9	2.5	-1.6	-1.5	1.5	-1.2	-1.1
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.4	0.2	0.1	-0.3	-0.6	-0.6
Birth weight	0.1	0.3	0.4	0.7	0.5	-0.7	-0.1	-0.4
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.0	-1.0	-0.5	0.9	-0.2	-0.0
High blood pressure (siblings)	0.6	0.9	2.4	0.5	0.4	-0.6	1.1	1.5
Forced vital capacity (FVC), Best measure	1.2	4.2	4.8	2.0	2.2	-2.0	2.1	2.0
Body fat percentage	0.1	0.4	0.5	0.5	0.4	-0.6	0.7	0.7
Leg fat percentage (right)	0.1	0.4	0.6	0.7	0.4	-0.8	0.6	0.7
Arm fat-free mass (right)	0.8	4.3	6.7	2.6	2.2	-2.6	1.4	1.2
Exposure to tobacco smoke outside home	4.5	6.0	7.8	2.2	2.6	-2.1	2.8	2.5
Comparative body size at age 10	4.1	11.3	13.3	3.6	3.6	-3.7	3.1	2.8
Number of full brothers	0.7	0.9	2.2	0.4	0.4	-0.4	1.2	1.5
Worry too long after embarrassment	0.7	1.1	1.9	1.0	1.4	-0.9	1.2	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.4	0.1	-0.4	-0.7	-0.8
Wheeze or whistling in the chest in last year	1.1	2.0	3.1	1.8	1.7	-1.6	1.0	0.5
Number of children fathered	0.5	0.5	1.5	-0.0	-0.4	-0.0	-1.0	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	3.3	3.8	5.6	-1.5	-1.8	1.5	-2.3	-2.4
Age at first live birth	2.3	4.1	4.4	-2.0	-2.1	2.0	-2.1	-1.9
Pulse wave peak to peak time	0.6	0.7	1.2	1.0	0.9	-1.1	0.6	0.4
Health satisfaction	4.2	5.5	7.9	2.7	2.4	-2.8	1.9	1.6
Shortness of breath walking on level ground	2.4	2.9	5.1	2.0	2.3	-2.0	1.1	0.4
Qualifications: College or University degree	0.7	2.1	3.2	1.7	1.7	-1.8	0.9	0.6
Eye problems/disorders: None of the above	1.0	1.2	2.7	0.7	0.7	-0.7	1.4	1.6
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.8	0.3	0.4	-0.4	0.8	0.9
Emphysema/chronic bronchitis	0.5	0.6	1.1	1.0	1.0	-1.0	0.1	-0.1
Medication for pain relief, constipation, heartburn	0.5	0.9	1.6	-1.2	-1.0	1.3	-0.6	-0.5
Neck or shoulder pain in last month	0.2	0.3	0.7	0.8	0.5	-0.8	0.0	0.1
Medication: Blood pressure	1.7	3.0	3.8	-1.6	-1.9	1.5	-1.9	-1.7
Angina (self-reported)	1.4	1.8	3.8	1.9	1.2	-1.9	0.4	0.4
Migraine (self-reported)	0.4	0.5	1.0	-0.6	-1.0	0.6	-0.8	-0.3
Medication: Ibuprofen	2.7	3.2	3.9	1.7	1.7	-1.7	2.0	1.8
Medication: Allopurinol	0.5	0.6	2.1	-0.2	-0.0	0.3	-1.0	-1.4
Medication: Omeprazole	0.0	0.0	0.0	0.2	0.1	-0.2	0.1	-0.1
Medication: Seretide 50 evohaler	0.0	0.1	0.1	-0.3	0.2	0.3	0.2	0.0
Mean time to correctly identify matches	0.5	0.9	1.4	1.1	0.9	-1.2	0.6	0.8
Heart disease (mother)	0.1	0.2	0.4	0.5	0.1	-0.6	-0.4	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.7	0.0	0.2	-0.1	-0.6	-0.9
Whole body fat mass	0.5	2.3	2.9	1.7	1.5	-1.7	1.4	1.3
Leg fat mass (right)	0.6	2.1	3.0	1.7	1.3	-1.7	1.3	1.3
Arm predicted mass (right)	0.8	4.1	6.6	2.5	2.1	-2.6	1.4	1.2
Pulse rate, automated reading	0.8	2.7	5.3	-1.6	-2.3	1.7	-1.5	-0.9
Alcohol intake frequency.	2.3	5.4	5.9	2.2	2.3	-2.3	2.4	2.3
Comparative height size at age 10	4.9	27.1	36.1	6.0	5.5	-6.0	4.4	3.8
Number of full sisters	0.3	0.3	1.0	0.0	0.2	0.0	0.7	1.0
Suffer from ‘nerves’	0.2	0.4	1.1	-0.2	-0.3	0.3	0.7	1.1
Overall health rating	3.1	6.7	8.6	2.9	2.3	-2.9	2.3	2.4
Chest pain or discomfort	1.8	2.6	3.9	2.0	1.7	-2.0	1.1	0.9
Had major operations	0.2	0.2	0.5	0.5	0.3	-0.4	-0.4	-0.7
Age at last live birth	1.4	2.0	2.3	-1.4	-1.4	1.3	-1.5	-1.4
Family relationship satisfaction	0.4	0.5	0.8	0.9	0.6	-0.9	0.5	0.7
Leg pain on walking	1.6	2.0	3.4	1.7	1.5	-1.9	0.9	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.2	-1.1	-1.0	1.1	-0.3	-0.2
Commuting to job workplace: Car/motor vehicle	1.3	1.5	2.0	-1.3	-1.4	1.4	-1.1	-0.8
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.0	1.0	0.9	-0.9	0.5	0.5
Medication: Aspirin	1.0	1.3	2.2	1.5	1.1	-1.5	0.7	0.6
Supplements: Vitamin C	0.0	0.0	0.0	-0.2	0.1	0.2	0.1	-0.0
Knee pain experienced in last month	0.3	0.4	0.5	-0.7	-0.7	0.6	-0.7	-0.7
Hypertension (Self-reported)	0.1	0.2	0.4	-0.1	-0.3	-0.0	-0.7	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.4	1.1	1.2	-1.0	0.4	-0.0
Illnesses of father: Heart disease	5.1	7.0	10.1	3.2	2.9	-3.2	1.9	1.7
Illnesses of siblings: Diabetes	1.5	1.8	2.3	1.4	1.3	-1.5	1.2	1.2
Smoking status: Previous	2.9	4.3	6.7	2.6	2.3	-2.5	1.4	1.0
Forced expiratory volume in 1-second (FEV1), predicted	3.5	7.4	8.8	3.0	2.7	-2.9	2.5	2.4
Whole body fat-free mass	1.7	9.6	13.1	3.6	3.2	-3.6	2.5	2.2
Leg fat-free mass (right)	1.7	9.2	11.6	3.4	3.2	-3.4	2.7	2.4
Arm fat percentage (left)	0.0	0.1	0.2	0.1	0.1	-0.0	0.4	0.3
Average weekly red wine intake	0.2	0.3	0.5	0.6	0.7	-0.6	0.3	-0.2
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.6	-0.7	-0.1	0.8	-0.2	-0.6
Mood swings	0.1	0.1	0.2	0.4	0.3	-0.4	0.1	0.2
Loneliness, isolation	1.6	2.2	3.5	1.8	1.5	-1.9	0.9	0.9
Long-standing illness, disability or infirmity	1.2	1.9	3.4	1.7	1.7	-1.8	0.6	-0.0
Ever had bowel cancer screening	2.3	2.7	3.9	-1.4	-1.6	1.3	-2.0	-1.9
Diabetes diagnosed by doctor	0.5	0.9	1.7	1.3	1.1	-1.3	0.2	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.5	0.0	-0.1	-0.2	-0.7	-0.5
Friendships satisfaction	0.4	0.5	1.3	0.2	-0.1	-0.1	-0.9	-1.2
Qualifications: nursing, teaching	0.1	0.2	0.7	0.2	0.2	-0.2	-0.5	-0.9
Commuting to job workplace: Walk	1.7	1.8	3.0	1.5	1.7	-1.6	1.0	0.5
Eye problems/disorders: Cataract	0.6	0.7	1.4	1.0	1.2	-0.9	0.0	-0.4
Mouth/teeth dental problems: Mouth ulcers	2.7	4.3	6.6	-1.8	-1.7	1.8	-2.4	-2.6
Medication for cholesterol	1.7	2.5	3.4	-1.8	-1.8	1.9	-1.3	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.6	3.1	4.0	-2.0	-1.6	2.0	-1.6	-1.6
Back pain experienced in last month	1.5	2.1	3.3	-1.1	-1.5	1.0	-1.8	-1.7
Mineral and other dietary supplements	1.2	1.6	2.0	1.2	1.3	-1.1	1.4	1.2
Breast cancer (self-reported)	1.1	1.3	2.8	-0.8	-0.8	0.7	-1.4	-1.7
Asthma (self-reported)	0.5	0.9	1.5	1.2	1.2	-1.2	0.5	0.1
Osteoporosis (self-reported)	0.0	0.0	0.2	-0.0	-0.0	0.1	-0.3	-0.4
Osteoarthritis (self-reported)	0.1	0.2	0.4	-0.4	-0.2	0.3	-0.5	-0.6
Medication: Aspirin	0.5	0.7	1.3	1.1	0.8	-1.1	0.3	0.2
Medication: Gliclazide	2.9	3.2	4.9	1.4	1.7	-1.4	2.2	2.2
Illnesses of father: None of the above (group 1)	0.7	0.9	1.8	-1.3	-0.9	1.4	-0.3	-0.1
Smoking status: Current	0.1	0.1	0.3	0.4	0.4	-0.5	0.2	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.1	-0.3	0.2	0.3	0.2	-0.1
Whole body water mass	1.6	8.9	12.3	3.5	3.1	-3.5	2.4	2.2
Leg predicted mass (right)	1.7	9.2	11.8	3.4	3.2	-3.4	2.7	2.3
Arm fat mass (left)	0.3	1.2	1.3	1.1	1.0	-1.1	1.2	1.0
Number of self-reported non-cancer illnesses	0.2	0.4	1.3	0.1	0.1	-0.2	-0.8	-1.1
Average weekly champagne plus white wine intake	0.6	0.8	1.2	0.8	1.1	-0.8	1.1	0.7
Miserableness	2.5	4.3	4.9	2.2	2.2	-2.2	2.0	1.9
Guilty feelings	2.3	3.5	4.4	1.7	2.1	-1.7	2.0	1.8
Wears glasses or contact lenses	1.2	1.3	2.3	1.1	1.5	-1.2	1.0	0.6
Ever taken oral contraceptive pill	0.2	0.2	0.6	0.1	0.2	-0.1	-0.6	-0.8
Hearing aid user	0.3	0.3	0.4	0.6	0.5	-0.6	-0.4	-0.6
Mother’s age at death	3.2	4.0	6.0	-2.0	-1.6	1.9	-2.0	-2.5
Financial situation satisfaction	4.6	5.7	7.6	2.5	2.8	-2.5	2.3	1.9
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	0.2	0.5	-0.1	0.4	0.2
Commuting to job workplace: Public transport	3.0	3.6	5.0	2.1	2.2	-2.2	1.4	1.1
Eye problems/disorders: Glaucoma	0.4	0.5	0.7	-0.7	-0.7	0.9	-0.5	-0.6
Medication: Blood pressure	1.2	2.3	4.1	1.9	1.7	-2.0	0.8	0.7
Pain type(s) experienced in last month: Hip pain	1.4	1.8	2.7	1.5	1.0	-1.6	1.0	1.4
Supplements: Fish oil (including cod liver oil)	1.2	1.6	1.7	-1.3	-1.2	1.1	-1.3	-1.2
High cholesterol (Self-reported)	2.4	4.3	6.6	2.6	2.4	-2.5	1.4	0.9
Medication: Bendroflumethiazide	0.2	0.3	0.4	0.5	0.5	-0.6	-0.4	-0.6
Medication: Paracetamol	0.3	0.5	1.3	-0.1	-0.6	0.1	-1.1	-1.0
Medication: Lisinopril	1.4	1.8	2.3	-1.3	-1.1	1.4	-1.3	-1.5
Medication: Atorvastatin	4.4	5.4	8.9	1.8	2.0	-1.8	2.8	3.0
Illnesses of father: High blood pressure	0.3	0.3	0.7	-0.7	-0.8	0.6	0.0	0.3
Alcohol drinker status: Never	1.4	1.6	3.1	1.7	1.3	-1.8	0.4	0.2
Ever smoked	2.5	4.4	6.6	2.6	2.3	-2.6	1.5	1.2
Basal metabolic rate	1.7	9.5	12.5	3.5	3.2	-3.5	2.6	2.4
Leg fat percentage (left)	0.0	0.1	0.2	0.4	0.1	-0.4	0.3	0.3
Arm fat-free mass (left)	1.3	6.6	9.6	3.1	2.6	-3.1	2.0	1.8
Number of operations (self-reported)	0.6	0.9	2.2	0.8	0.6	-0.8	-0.9	-1.5
Average weekly beer plus cider intake	0.2	0.3	0.6	-0.4	0.0	0.4	0.7	0.8
Irritability	0.4	0.6	0.7	-0.7	-0.7	0.7	-0.9	-0.9
Risk taking	2.4	3.5	4.0	-2.0	-2.0	2.0	-1.8	-1.6
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.5	0.1	0.3	-0.2	0.7	0.6
Fractured/broken bones in last 5 years	2.4	3.1	4.5	-1.4	-1.9	1.4	-2.1	-1.8
Age started oral contraceptive pill	0.2	0.2	0.4	0.6	0.2	-0.6	-0.3	-0.3
Diastolic blood pressure, automated reading	1.0	3.2	6.3	-2.1	-2.5	2.0	-1.1	-0.1
Ever depressed for a whole week	1.4	1.7	3.2	1.7	1.5	-1.8	0.4	0.1
Unable to work because of sickness or disability	1.3	1.7	2.5	1.5	1.1	-1.6	1.0	1.1
Commuting to job workplace: Cycle	1.0	1.2	1.4	1.0	1.1	-1.0	1.2	1.2
Myopia	0.1	0.1	0.1	0.2	0.4	-0.3	0.0	-0.4
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.1	-0.2	0.2	0.3	0.4	0.1
Cholesterol lowering medication	7.4	10.9	12.3	3.5	3.4	-3.5	3.2	2.9
Medication: Omeprazole (e.g. Zanprol)	0.0	0.1	0.2	0.1	0.2	-0.1	-0.1	-0.4
Pain experienced in last month	0.0	0.1	0.1	-0.3	-0.1	0.4	0.2	0.1
Supplements: Calcium	0.7	0.8	1.4	-0.6	-0.8	0.6	-1.2	-1.1
Basal cell carcinoma (self-reported)	1.6	1.9	5.0	0.5	0.8	-0.5	1.9	2.2
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.4	0.5	0.4	-0.6	0.4	0.6
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	4.0	1.9	2.0	-1.9	1.1	0.7
Heart disease (siblings)	1.2	1.5	1.8	-1.2	-1.3	1.1	-1.3	-1.1
Alcohol drinker status: Previous	0.3	0.3	0.5	0.4	0.7	-0.5	-0.2	-0.7
Pack years of smoking	0.0	0.1	0.1	0.4	0.3	-0.3	0.1	-0.1
Impedance of whole body	0.3	1.7	3.0	0.9	1.1	-0.9	1.6	1.7
Leg fat mass (left)	0.4	1.7	2.5	1.5	1.2	-1.6	1.1	1.1
Arm predicted mass (left)	1.3	6.5	9.8	3.1	2.6	-3.1	1.9	1.7