TWAS hub - RCN3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.2290	0.0910	9.7e-03	0.019	NA	-0.008	NA	0.020	7.8e-02	NA	7.3e-01	NA	7.2e-02
2	GTEx	Colon Transverse	0.1760	0.0670	3.4e-03	0.102	NA	0.034	NA	0.062	1.4e-05	NA	9.8e-03	NA	6.8e-04
3	GTEx	Whole Blood	0.1800	0.0470	6.0e-06	0.118	NA	0.069	NA	0.104	5.0e-11	NA	6.0e-07	NA	7.4e-10
4	YFS	Blood	0.1747	0.0269	0.0e+00	0.124	0.102	0.124	0.132	0.124	1.5e-38	1.7e-31	2.5e-38	8e-41	2.7e-38
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0252	0.0160	2.8e-03	0.014	0.017	0.010	NA	0.012	9.5e-03	4.7e-03	2.3e-02	NA	1.6e-02
6	TCGA	Brain Lower Grade Glioma	0.0195	0.0128	5.1e-03	0.006	0.013	0.004	NA	0.004	6.6e-02	1.1e-02	9.0e-02	NA	9.4e-02
7	TCGA	Prostate Adenocarcinoma	0.0555	0.0334	9.6e-03	-0.002	0.019	0.014	NA	0.002	5.6e-01	3.5e-03	1.2e-02	NA	2.1e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Blood Red Count	7.0	67.2	144.0	1.4	-8.3	-8.3	-7.7	12.0	-10.4	4.3
Hypothyroidism/myxoedema (self-reported)	6.2	12.2	19.4	-0.8	4.1	3.8	3.6	-4.3	4.4	-1.6
LDL Cholesterol	5.2	8.3	12.5	-2.1	-3.1	-2.7	-2.7	3.5	-3.4	2.3
Ever had stillbirth, spontaneous miscarriage or termination	5.2	5.5	7.5	-0.3	2.7	2.6	2.5	-2.3	2.5	-2.6
Triglycerides	4.4	7.1	12.2	0.4	-2.9	-2.7	-2.7	3.5	-3.5	1.7
Medication: Levothyroxine sodium	4.1	7.0	12.2	-1.1	3.1	2.8	2.6	-3.4	3.5	-0.6
Back pain experienced in last month	4.1	6.0	7.8	-1.0	2.8	2.6	2.8	-2.8	2.5	-2.3
Illnesses of siblings	4.0	5.7	9.8	0.6	-3.1	-3.0	-3.1	1.6	-2.4	1.6
Loud music exposure frequency	3.6	4.0	6.3	-1.3	-2.5	-2.5	-2.3	1.6	-1.5	1.9
Exposure to tobacco smoke outside home	3.6	4.7	8.6	-0.9	-2.3	-2.4	-2.2	2.9	-2.5	1.3
Medication: Atorvastatin	3.6	4.5	6.2	-0.6	-2.3	-2.5	-2.4	2.3	-2.5	1.7
Supplements: Fish oil (including cod liver oil)	3.5	4.5	6.7	-1.2	2.6	2.5	2.3	-2.2	2.3	-1.3
Hypothyroidism (self reported)	3.1	7.1	14.1	-0.1	3.0	2.9	2.5	-3.5	3.8	-0.4
Illnesses of mother	3.1	3.8	9.3	0.8	-1.9	-2.1	-1.5	2.5	-3.1	0.5
Illnesses of father: High blood pressure	3.1	3.8	5.1	-0.5	2.3	2.2	2.0	-2.2	2.0	-2.0
Crohns Disease (2017)	3.0	6.7	10.5	-0.2	-3.2	-3.2	-3.2	2.6	-2.6	1.4
Medication: Blood pressure	3.0	5.3	9.4	1.1	2.7	2.4	2.1	-2.7	3.1	-1.3
Age at last live birth	3.0	4.4	5.9	2.4	2.2	2.2	2.4	-1.8	1.6	-1.8
Bipolar Disorder or Schizophrenia	2.9	7.0	15.7	0.0	2.6	2.5	2.3	-3.8	4.0	-0.7
Lupus	2.8	4.2	6.2	0.9	2.0	2.0	2.2	-2.5	2.4	-1.8
Schizophrenia (2014)	2.8	6.2	14.3	-0.6	2.3	2.5	2.1	-3.8	3.5	-0.4
Schizophrenia (2018)	2.7	5.5	13.7	-0.2	2.1	2.1	1.8	-3.7	3.5	-0.8
Allergy or Eczema	2.7	7.2	19.7	0.5	-2.4	-2.5	-1.8	3.9	-4.4	0.3
High cholesterol (Self-reported)	2.7	4.8	7.0	-0.1	-2.5	-2.4	-2.5	2.6	-2.2	1.9
Cholesterol lowering medication	2.7	4.0	9.0	-1.4	-1.9	-1.9	-1.7	3.0	-2.5	0.9
Hayfever, allergic rhinitis or eczema	2.6	5.7	13.9	0.2	-2.3	-2.5	-2.0	3.1	-3.7	0.9
Breast cancer (self-reported)	2.5	3.0	4.6	-1.5	2.1	1.9	2.1	-1.3	1.7	-1.3
Type 2 Diabetes (T2D) (2018)	2.4	4.6	7.0	1.9	-2.2	-2.2	-1.9	2.6	-2.6	0.9
Wheeze or whistling in the chest in last year	2.4	4.3	8.8	0.4	-1.8	-1.7	-1.4	3.0	-2.9	2.0
Had major operations	2.4	2.8	3.5	-0.6	-1.9	-1.7	-1.7	1.8	-1.7	1.9
Smoking status: Previous	2.4	3.6	6.4	-1.2	-2.0	-1.8	-1.8	2.5	-2.2	1.5
Mineral and other dietary supplements	2.4	3.2	5.1	0.4	-2.0	-2.0	-1.8	1.9	-2.3	1.3
Serious illness, injury or assault to yourself	2.3	2.8	3.7	-0.4	1.9	1.9	1.9	-1.7	1.7	-1.7
Ever had bowel cancer screening	2.3	2.6	3.8	-0.7	1.9	1.6	1.9	-1.5	1.6	-1.9
Headache pain in last month	2.2	3.7	6.6	0.4	-2.1	-2.0	-1.8	2.6	-2.0	2.0
Age at First Birth	2.1	3.1	5.3	-0.7	-2.0	-2.2	-2.3	1.2	-0.8	2.3
Ever had hysterectomy (womb removed)	2.1	2.3	3.4	-0.7	1.8	1.8	1.7	-1.3	1.5	-1.6
Chronic bronchitis/emphysema (mother)	2.1	2.4	4.5	0.4	1.7	1.7	1.8	-1.5	1.1	-2.1
Medication: Gliclazide	2.1	2.4	5.2	2.3	-1.3	-1.7	-1.2	1.8	-1.6	-0.2
Pain type(s) experienced in last month: Hip pain	2.1	2.6	3.9	0.5	1.9	1.7	1.9	-1.1	1.6	-2.0
Ulcerative Colitis	2.0	2.9	6.7	-1.2	1.8	1.7	1.5	-1.6	1.2	-2.6
Waist Hip Ratio (WHR)	2.0	8.9	14.2	1.7	-3.0	-3.0	-3.1	3.8	-3.1	2.8
Diabetes (father)	2.0	2.5	5.9	0.1	-1.6	-1.6	-1.2	2.1	-2.4	0.8
Allergy	2.0	4.5	15.0	0.2	1.5	1.6	0.9	-3.3	3.9	0.0
Medication: Ventolin 100micrograms inhaler	2.0	2.6	4.7	-1.3	1.8	1.7	2.2	-1.0	0.2	-2.1
Blood Platelet Count	1.9	22.3	39.1	-1.6	-5.0	-4.7	-4.4	6.2	-6.1	3.2
Systolic blood pressure, automated reading	1.9	5.4	13.8	-0.5	2.3	2.4	2.0	-3.0	3.7	-0.5
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	5.6	2.3	-1.5	-1.6	-1.4	1.9	-2.4	-0.7
Exposure to tobacco smoke at home	1.9	2.2	3.6	1.6	-1.8	-1.8	-1.9	0.7	-0.8	1.1
Medication: Amlodipine	1.9	2.6	4.5	0.2	2.1	1.7	1.8	-1.7	2.1	-0.6
Medication: Ibuprofen	1.9	2.2	3.9	0.6	-1.5	-1.4	-1.4	2.0	-1.9	1.3
Hair/balding pattern: Pattern 2	1.8	2.3	3.6	0.3	1.6	1.5	1.4	-1.7	1.6	-1.9
Forced vital capacity (FVC)	1.8	7.1	11.3	-2.3	-2.7	-2.7	-2.4	3.4	-3.3	1.4
Illnesses of father: Heart disease	1.8	2.5	6.8	0.2	-1.2	-1.3	-1.0	2.6	-2.0	1.6
Prostate Cancer	1.7	2.4	4.6	1.0	-1.5	-1.7	-1.4	2.1	-2.0	0.7
Current tobacco smoking	1.7	2.9	7.3	2.7	1.4	1.2	1.1	-1.8	1.6	-1.5
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	3.4	0.4	1.7	1.5	1.6	-1.7	1.8	-0.5
Age at first live birth	1.7	3.1	5.3	1.4	1.7	1.7	1.6	-2.3	2.3	-1.0
Knee pain experienced in last month	1.7	2.6	3.9	0.2	2.0	1.8	1.9	-1.6	1.5	-1.7
Mother’s age at death	1.7	2.1	3.3	-1.8	1.4	1.4	0.9	-1.8	1.7	-0.9
Financial situation satisfaction	1.7	2.1	5.6	-0.2	-1.4	-1.4	-1.2	1.9	-2.4	-0.2
Average weekly fortified wine intake	1.6	1.8	4.9	0.8	-1.2	-1.0	-0.8	2.2	-1.8	1.1
Comparative height size at age 10	1.6	8.7	19.3	-0.5	-2.9	-3.1	-2.4	4.2	-4.4	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.8	3.2	-1.2	-1.2	-1.3	-1.4	1.5	-1.0	1.8
Osteoarthritis (self-reported)	1.6	2.1	3.1	-1.7	1.7	1.6	1.8	-0.8	1.0	-1.0
Smoking status: Current	1.6	2.5	5.7	2.4	1.3	1.1	1.1	-1.6	1.5	-1.7
Irritability	1.6	2.6	5.3	2.3	1.3	1.0	1.0	-1.9	2.2	-1.0
Vascular/heart problems diagnosed by doctor	1.6	4.2	6.6	-1.0	-2.6	-2.3	-2.2	2.1	-2.5	1.1
Bipolar Disorder (2018)	1.5	2.4	3.9	0.2	1.9	1.9	2.0	-1.4	1.9	0.0
Qualifications: CSEs or equivalent	1.5	1.9	3.5	-0.4	-1.5	-1.7	-1.7	1.2	-0.8	1.9
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	3.6	0.2	-1.3	-1.3	-1.2	1.9	-1.9	1.1
Heart disease (mother)	1.5	1.8	2.7	0.9	1.5	1.6	1.6	-0.9	1.3	-1.2
Ulcerative Colitis (UC)	1.4	2.6	5.9	-1.9	1.4	1.4	1.2	-1.4	0.9	-2.4
Frequency of depressed mood in last 2 weeks	1.4	2.0	3.7	0.6	-1.8	-1.8	-1.9	0.6	-0.8	1.4
High blood pressure (mother)	1.4	1.9	4.6	0.3	1.1	1.2	0.8	-2.0	2.1	-1.1
Forced expiratory volume in 1-second (FEV1)	1.4	4.6	6.6	-2.6	-2.2	-2.2	-2.0	2.2	-2.3	1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.4	3.0	5.6	0.1	-1.9	-1.9	-1.6	2.2	-2.4	0.1
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	5.2	-0.6	-1.0	-0.9	-0.2	2.2	-2.3	-0.7
Taking other prescription medications	1.3	2.1	4.6	-1.4	1.8	1.8	2.1	-0.6	0.9	-0.7
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	4.1	0.4	-1.0	-1.1	-0.9	1.8	-2.0	1.0
Fluid intelligence score	1.3	2.7	5.5	-1.1	-1.7	-1.8	-1.4	2.0	-2.3	-0.6
Tense / ‘highly strung’	1.3	2.2	6.1	-0.2	1.3	1.3	0.8	-2.2	2.5	-0.8
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	2.6	-0.9	1.4	1.4	1.3	-1.4	1.6	-0.9
Blood clot in the leg (DVT)	1.3	1.7	4.8	-0.7	-0.8	-0.8	-0.1	2.2	-2.2	-0.9
Forced vital capacity (FVC), Best measure	1.3	4.7	6.3	-2.3	-2.2	-2.2	-2.1	2.5	-2.5	1.0
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.2	-0.5	-1.3	-1.2	-1.1	1.7	-1.8	0.8
Number of self-reported non-cancer illnesses	1.3	2.2	4.3	-1.2	2.1	2.0	2.0	-0.5	0.9	-0.7
Tinnitus: Yes, now most or all of the time	1.3	1.5	3.1	-1.3	-0.7	-0.6	-0.5	1.8	-1.8	1.0
Medication: Bendroflumethiazide	1.3	2.0	4.3	-0.2	1.7	1.6	1.6	-0.8	1.0	-2.1
Risk taking	1.3	1.9	4.9	1.1	1.3	1.3	1.0	-1.7	2.2	0.3
Heart disease (siblings)	1.3	1.5	2.6	-0.6	1.6	1.4	1.6	-0.9	1.5	-0.5
HDL Cholesterol	1.2	2.0	2.9	-1.7	-1.3	-1.5	-1.5	1.2	-1.0	1.6
Age when periods started (menarche)	1.2	2.8	6.2	-1.8	1.5	1.3	1.2	-2.2	2.5	0.5
Past tobacco smoking	1.2	2.1	4.5	0.7	1.5	1.3	1.4	-2.1	1.8	-0.8
Alcohol usually taken with meals	1.2	1.9	8.7	-3.0	-0.8	-0.7	-0.6	1.1	-1.3	-0.2
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	2.2	0.2	-1.5	-1.5	-1.2	1.4	-1.3	0.8
Hair/balding pattern: Pattern 4	1.2	3.0	8.0	0.5	-1.6	-1.4	-1.1	2.8	-2.2	1.5
Birth weight of first child	1.2	2.3	3.8	1.6	-1.8	-1.6	-1.9	-0.1	-0.1	1.9
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	5.5	-2.4	-1.0	-0.8	-0.9	1.8	-1.5	0.1
Long-standing illness, disability or infirmity	1.2	1.8	4.2	-0.3	1.6	1.4	2.1	0.3	-0.2	-1.9
Alzheimer’s Disease (including proxy)	1.1	1.6	2.9	-1.2	1.7	1.4	1.1	-1.4	1.3	-0.5
Lung FEV1/FVC ratio	1.1	5.6	11.7	0.3	2.2	2.1	1.6	-3.4	3.3	-2.1
Diabetes (mother)	1.1	1.3	3.3	0.4	-1.3	-1.1	-0.9	1.8	-1.4	0.6
Pack years adult smoking proportion	1.1	1.7	8.8	3.0	-0.8	-1.0	-0.9	-0.0	-0.6	0.5
High blood pressure	1.1	3.2	4.7	1.2	2.1	2.0	1.9	-1.7	2.2	-1.0
Impedance of arm (right)	1.1	5.3	9.0	-3.0	-2.2	-2.0	-2.5	2.3	-2.5	1.1
Impedance of arm (left)	1.1	5.0	12.0	-3.5	-2.0	-1.8	-2.4	1.9	-2.1	1.4
High blood pressure (siblings)	1.1	1.6	2.9	-0.7	1.7	1.6	1.7	-0.4	1.3	-0.9
Hypertension (Self-reported)	1.1	3.0	4.4	1.4	2.1	1.9	1.8	-1.7	2.1	-0.9
Diabetes diagnosed by doctor	1.1	1.8	4.1	2.0	-1.1	-1.1	-0.9	1.6	-1.5	0.6
Eye problems/disorders: Glaucoma	1.1	1.3	2.7	0.0	-1.5	-1.6	-1.5	0.7	-0.9	1.0
Major Depression (MDD)	1.0	1.2	2.2	0.6	-1.5	-1.3	-1.2	1.0	-1.1	0.8
Primary Biliary Cirrhosis	1.0	1.4	3.4	-0.2	-1.4	-1.1	-0.9	1.8	-1.5	0.4
Rheumatoid Arthritis	1.0	1.3	3.7	-1.1	1.3	1.3	1.9	0.0	-0.0	-1.0
Noisy workplace	1.0	1.2	4.6	2.1	1.0	0.6	0.8	-0.7	0.5	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.0	5.1	-2.3	-1.8	-1.9	-1.8	1.6	-1.7	0.7
Standing height	1.0	10.3	20.6	-1.6	-3.2	-3.5	-2.8	4.3	-4.5	-0.7
Ever had prostate specific antigen (PSA) test	1.0	1.1	1.9	0.8	1.3	1.1	1.4	-0.8	0.9	-1.0
Myopia	1.0	1.4	4.4	-1.4	0.8	0.9	1.0	-0.8	0.5	-2.1
Pain experienced in last month	1.0	1.6	3.8	0.1	-1.5	-1.4	-1.9	0.8	-0.6	1.5
Pack years of smoking	1.0	1.5	9.1	3.0	-0.5	-0.8	-0.6	-0.0	-0.5	0.4
Intelligence (Savage-Jansen 2018)	0.9	2.9	7.5	-2.0	-1.2	-1.1	-0.9	2.1	-2.7	-0.8
Crohns Disease (2012)	0.9	1.5	2.3	-0.5	-1.4	-1.5	-1.4	1.4	-1.0	1.1
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.9	-0.9	1.5	1.1	1.7	0.1	0.2	-1.1
Medication for hormone replacement therapy	0.9	1.0	1.6	-0.9	1.3	1.2	0.9	-0.9	1.1	-0.7
Supplements: Zinc	0.9	1.0	3.4	1.8	0.7	0.6	0.7	-0.8	0.4	-1.1
Medication: Metformin	0.9	1.2	3.3	1.8	-0.5	-0.5	-0.4	1.5	-1.4	-0.1
Diabetes (self-reported)	0.9	1.3	5.0	2.2	-0.9	-0.9	-0.7	1.0	-1.0	0.6
Hair/balding pattern: Pattern 3	0.9	1.4	2.2	1.2	-1.3	-1.5	-1.4	1.1	-0.8	0.8
Pulse wave Arterial Stiffness index	0.9	1.1	2.2	0.2	-1.1	-1.2	-0.8	1.0	-0.9	1.5
Peak expiratory flow (PEF)	0.9	2.2	6.3	-2.5	-1.2	-1.2	-0.9	1.6	-1.7	0.2
Pulse wave reflection index	0.9	1.1	1.7	0.3	-1.2	-1.0	-1.0	1.3	-1.3	0.9
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	3.0	0.0	-1.5	-1.4	-1.0	1.4	-1.7	0.5
Commuting to job workplace: Car/motor vehicle	0.9	1.0	4.2	0.3	-1.0	-0.9	-1.1	0.2	0.2	2.0
Guilty feelings	0.9	1.4	3.7	-0.5	-1.1	-0.9	-1.1	1.9	-1.5	0.7
Ever taken oral contraceptive pill	0.9	1.0	3.9	2.0	-1.0	-0.9	-0.8	0.2	-0.8	-0.2
Alzheimer’s Disease (in father)	0.8	0.8	3.9	-2.0	0.3	0.6	0.1	-0.9	0.8	0.2
Verbal and Numeric Reasoning (VNR)	0.8	1.9	4.9	-0.9	-1.1	-0.9	-0.5	1.7	-2.2	-1.5
Ovarian Cancer	0.8	1.1	2.9	0.4	0.6	0.7	0.9	-1.7	1.5	-0.9
Systolic Blood Pressure	0.8	4.2	10.4	1.0	1.9	2.1	1.5	-2.8	3.2	-0.1
Medication: Atenolol	0.8	0.9	1.7	0.1	1.2	1.3	1.1	-0.9	1.2	-0.2
Sitting height	0.8	5.9	11.4	-1.0	-2.4	-2.6	-2.1	3.4	-3.4	-1.1
Medication: Simvastatin	0.8	1.2	1.8	-0.9	-1.0	-1.3	-1.4	1.3	-1.0	0.2
Alcohol intake versus 10 years previously	0.8	1.3	2.3	0.1	1.5	1.2	1.3	-1.1	1.2	-0.7
Breastfed as a baby	0.8	1.0	3.2	1.8	-0.9	-1.0	-0.9	0.8	-0.8	0.0
Worry too long after embarrassment	0.8	1.3	2.5	-1.6	-1.1	-0.9	-1.0	1.2	-1.4	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	3.1	-1.8	0.7	0.5	0.4	-0.4	1.2	0.7
Mouth/teeth dental problems: Loose teeth	0.8	1.0	1.9	1.4	1.0	0.8	1.2	-0.3	0.5	-1.3
Eye problems/disorders: Cataract	0.8	0.9	2.4	-0.8	-0.7	-0.7	-0.3	1.6	-1.4	0.6
Diastolic blood pressure, automated reading	0.8	2.6	8.4	0.1	1.2	1.2	1.2	-2.2	2.9	-0.3
Basal cell carcinoma (self-reported)	0.8	1.0	3.8	-1.9	-0.7	-0.7	-0.2	0.9	-1.0	-0.2
Neuroticism	0.7	1.6	2.9	0.7	-1.5	-1.7	-1.6	1.2	-1.2	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	3.6	1.9	-0.1	-0.3	-0.3	-1.0	0.5	-1.1
Multivitamins +/- minerals	0.7	0.9	2.9	-0.1	0.7	0.8	0.6	-1.7	1.3	-0.7
Leg predicted mass (left)	0.7	3.5	7.7	0.7	-1.9	-1.9	-1.2	2.6	-2.8	-0.5
Number of live births	0.7	1.0	3.0	-0.8	-0.6	-0.7	-0.5	1.7	-1.4	0.7
Asthma	0.7	1.4	5.0	-0.2	-0.4	-0.3	0.2	2.0	-2.2	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	1.6	0.4	1.2	1.2	1.1	-1.0	1.3	-0.3
Pulse wave peak to peak time	0.7	0.9	2.5	-0.5	1.0	1.0	0.7	-0.7	0.7	-1.6
Leg fat-free mass (right)	0.7	3.9	8.4	0.5	-2.1	-2.2	-1.5	2.6	-2.9	-0.2
Medication for cholesterol	0.7	1.0	2.0	0.6	-1.4	-1.2	-1.2	0.3	-0.6	1.2
Leg predicted mass (right)	0.7	3.8	8.4	0.5	-2.1	-2.2	-1.4	2.6	-2.9	-0.2
Miserableness	0.7	1.1	4.4	2.1	-0.6	-0.8	-0.7	0.5	-1.1	-0.8
Fractured/broken bones in last 5 years	0.7	1.0	1.8	-1.3	0.7	0.6	0.5	-1.3	1.4	0.6
HbA1C	0.6	0.7	1.2	-1.1	0.8	0.9	1.1	-0.5	-0.0	-0.9
Blood White Count	0.6	4.7	8.2	1.8	-2.2	-1.9	-1.6	2.9	-2.7	1.8
Number of treatments/medications taken	0.6	1.1	2.5	-1.6	1.2	1.3	1.2	-0.1	0.5	-0.4
Leg fat-free mass (left)	0.6	3.4	7.6	0.8	-1.9	-1.9	-1.2	2.6	-2.7	-0.5
Qualifications: None of the above	0.6	1.3	2.6	-0.8	1.0	1.2	1.0	-1.5	1.6	-0.3
Medication: Ramipril	0.6	0.8	5.0	2.2	0.1	-0.2	-0.2	0.2	-0.3	-0.4
Medication: Paracetamol	0.6	0.9	1.9	-0.3	1.0	1.1	0.9	-1.1	1.4	0.3
Gout (self-reported)	0.6	0.9	2.9	0.8	-0.8	-0.9	-1.0	0.6	0.0	1.7
Emphysema/chronic bronchitis	0.6	0.6	1.0	1.0	0.7	0.6	0.9	1.0	-0.6	-0.7
Leg pain on walking	0.6	0.8	1.4	-1.1	0.7	0.6	1.1	0.5	-0.7	-1.2
Medication: Aspirin	0.6	0.8	1.6	-0.7	-0.7	-0.9	-0.7	1.3	-1.1	0.7
Asthma (self-reported)	0.6	1.2	4.3	-0.2	-0.4	-0.4	0.1	1.9	-2.1	0.5
Supplements: Calcium	0.6	0.6	2.7	1.6	-0.5	-0.8	-0.7	-0.4	0.3	0.2
Alcohol drinker status: Previous	0.6	0.7	1.5	-0.2	0.9	0.9	1.2	-0.1	-0.5	-1.2
Body Mass Index (BMI) (2010)	0.5	0.6	2.1	-0.2	1.0	1.1	1.5	0.0	0.0	0.0
Fasting Glucose	0.5	0.6	2.8	1.7	0.6	0.3	0.5	-0.5	0.7	-0.3
Height	0.5	10.0	23.4	-1.8	-2.6	-3.1	-1.9	4.2	-4.8	-2.3
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.3	1.1	-0.7	-0.6	-0.6	0.4	-1.0	-0.3
Waist circumference	0.5	1.6	5.1	2.2	-1.0	-1.0	-0.6	1.7	-0.9	0.6
Hearing difficulty/problems with background noise	0.5	0.7	1.9	-0.3	1.0	0.9	1.1	-0.3	0.2	-1.4
Mouth/teeth dental problems	0.5	0.8	1.2	-0.9	-1.0	-0.8	-1.1	0.9	-1.1	0.4
Time employed in main current job	0.5	0.6	3.4	-1.8	0.4	0.3	0.1	-0.2	0.6	0.1
Worrier / anxious feelings	0.5	1.0	3.4	-0.7	-0.4	-0.5	-0.1	1.9	-1.4	-0.6
Qualifications: A levels/AS levels or equivalent	0.5	1.0	2.8	0.6	-1.0	-0.7	-0.9	1.2	-1.7	-0.7
Prospective memory result	0.5	0.6	1.3	1.0	0.0	-0.1	0.1	-1.0	1.1	1.1
Length of working week for main job	0.5	0.6	1.1	-0.6	1.0	0.9	0.8	-0.5	0.8	-0.5
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.3	1.1	-0.3	-0.3	-0.1	0.7	-1.2	-1.0
Leg fat percentage (right)	0.5	1.8	5.9	2.4	1.1	1.1	1.4	-0.1	1.4	-0.6
Medication: Allopurinol	0.5	0.7	2.3	0.6	-0.8	-0.7	-0.8	0.5	-0.2	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.5	1.0	0.3	0.9	0.6	1.0	-0.6	0.8	-0.8
Pulse rate, automated reading	0.5	1.6	6.1	2.5	-0.5	-1.0	-0.4	-0.8	1.3	1.0
Chest pain or discomfort	0.5	0.8	2.2	1.1	-0.3	-0.6	-0.4	1.2	-1.5	0.3
Commuting to job workplace: Walk	0.5	0.6	1.7	0.1	-0.2	-0.1	0.2	1.2	-1.3	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	5.2	-2.3	-0.5	-0.6	-0.7	0.5	-0.2	0.9
Wears glasses or contact lenses	0.5	0.6	3.3	-0.4	0.5	0.5	0.4	-0.3	0.2	-1.8
Commuting to job workplace: Public transport	0.5	0.6	1.5	-0.5	-0.8	-0.5	-0.7	1.1	-1.2	-0.5
Leg fat percentage (left)	0.5	1.6	5.5	2.3	1.0	1.0	1.2	-0.4	1.5	-0.4
Depression (Nagel 2018)	0.4	0.6	2.2	1.5	-0.3	-0.5	-0.4	-0.9	0.5	-0.2
Worry (Nagel 2018)	0.4	0.8	1.3	-0.5	-1.1	-1.1	-1.0	1.1	-1.0	-0.1
Irritable Bowel Disease (IBD)	0.4	1.0	2.7	-1.6	-0.9	-0.8	-0.9	0.5	-1.0	-1.0
Neuroticism (2016)	0.4	0.6	1.1	-0.4	-0.7	-1.0	-0.5	1.0	-1.1	-0.1
Respiratory disease	0.4	1.0	2.5	-0.8	0.5	0.4	1.0	1.4	-1.6	-0.4
Hand grip strength (left)	0.4	1.1	2.4	0.0	0.9	0.8	0.8	-1.6	1.6	0.8
Severe depression (siblings)	0.4	0.4	1.1	-1.0	0.0	0.0	0.2	1.0	-0.9	-0.2
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.9	-0.8	-0.4	-0.6	-0.4	0.9	-1.0	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.1	-0.3	-0.9	-0.6	-0.9	0.9	-1.1	0.4
Had menopause	0.4	0.5	0.9	0.9	0.4	0.2	0.2	-0.9	0.9	-0.9
Pain all over the body in last month	0.4	0.4	1.1	-0.2	1.0	0.7	1.1	0.4	0.1	0.3
Medication: Lansoprazole	0.4	0.4	1.0	0.4	0.8	0.7	0.7	-0.4	1.0	0.3
Number of full sisters	0.4	0.5	1.7	-1.3	-0.4	-0.1	-0.4	0.6	-0.8	0.8
Overall health rating	0.4	1.0	3.0	1.7	-0.1	-0.4	0.1	1.2	-1.3	-0.6
Illnesses of siblings: Diabetes	0.4	0.5	0.9	-0.2	1.0	0.9	1.0	0.5	-0.2	-0.6
Whole body fat-free mass	0.4	2.2	4.8	0.8	-1.4	-1.5	-0.7	2.1	-2.2	-0.8
Medication: Aspirin	0.4	0.6	1.1	-0.6	-0.6	-0.7	-0.7	1.1	-0.8	0.8
Illnesses of father: None of the above (group 1)	0.4	0.5	1.3	0.6	-1.1	-0.8	-1.0	-0.1	-0.2	0.2
Whole body water mass	0.4	2.0	4.4	0.9	-1.3	-1.5	-0.7	2.0	-2.1	-0.9
Average weekly champagne plus white wine intake	0.4	0.5	1.1	0.9	-0.6	-0.7	-0.7	0.6	-1.0	-0.2
Medication: Blood pressure	0.4	0.8	1.8	0.6	1.3	1.0	1.3	0.4	0.3	-0.6
Alcohol drinker status: Never	0.4	0.5	0.9	-0.9	-0.3	-0.4	-0.5	0.9	-0.4	1.0
Basal metabolic rate	0.4	2.3	4.7	1.1	-1.4	-1.5	-0.7	2.2	-2.1	-0.7
Commuting to job workplace: Cycle	0.4	0.5	1.1	-0.6	-0.5	-0.8	-0.5	0.6	-1.1	-0.4
Impedance of whole body	0.4	2.0	4.4	-2.1	-1.2	-1.1	-1.8	1.1	-1.0	1.3
Depressed Affect (Nagel 2018)	0.3	0.6	3.7	1.9	-0.2	-0.4	-0.2	-0.2	-0.1	-0.6
Mean Putamen Volume	0.3	0.4	0.8	-0.9	-0.5	-0.0	-0.2	0.8	-0.9	0.4
Heel T-Score	0.3	2.1	3.7	-1.4	1.8	1.7	1.9	-0.1	0.4	-1.5
Lung FVC	0.3	1.6	4.1	-2.0	-0.8	-0.9	-0.7	1.4	-1.2	1.3
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.1	1.1	-0.5	-0.7	-0.6	0.2	0.3	0.7
Hand grip strength (right)	0.3	0.9	2.7	0.2	0.3	0.3	0.3	-1.2	1.2	1.6
Townsend deprivation index at recruitment	0.3	0.5	1.3	1.1	0.4	0.6	0.5	0.5	-0.3	-0.9
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.5	0.4	0.4	0.3	0.6	-0.7	0.5	-0.7
Supplements: Glucosamine	0.3	0.4	1.2	0.0	0.6	0.6	0.5	-0.9	1.1	-0.2
Body mass index (BMI)	0.3	1.3	5.6	2.4	0.7	0.7	1.1	-0.4	1.1	-0.5
Number of incorrect matches in round	0.3	0.4	1.9	1.4	0.5	0.6	0.5	-0.4	0.2	0.1
Nervous feelings	0.3	0.6	1.4	-1.1	-0.7	-0.7	-0.4	1.2	-0.8	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.6	-1.0	0.9	0.8	0.8	0.0	0.4	-1.2
Weight	0.3	1.4	3.2	1.6	-1.0	-1.1	-0.4	1.8	-1.3	-0.5
Trunk fat-free mass	0.3	1.6	3.5	0.7	-1.0	-1.1	-0.3	1.8	-1.9	-1.2
Father’s age at death	0.3	0.3	0.7	0.4	0.6	0.4	0.6	-0.7	0.8	-0.6
Falls in the last year	0.3	0.4	2.3	1.5	-0.4	-0.5	-0.6	-0.2	-0.1	0.2
Pulse rate	0.3	0.6	3.1	1.8	-0.3	-0.8	-0.1	-0.4	0.0	-0.1
Trunk predicted mass	0.3	1.7	3.8	0.7	-1.1	-1.2	-0.4	1.9	-1.9	-1.1
Birth weight	0.3	0.6	1.8	-1.4	0.1	0.5	0.2	-0.4	0.2	-1.4
Arm fat-free mass (right)	0.3	1.4	2.5	1.6	-1.0	-1.2	-0.4	1.6	-1.5	-0.5
Comparative body size at age 10	0.3	0.9	2.1	-0.6	-0.6	-0.7	-0.5	1.4	-1.4	-1.1
Health satisfaction	0.3	0.4	1.7	0.4	0.5	0.3	0.5	0.1	-0.4	-1.3
Shortness of breath walking on level ground	0.3	0.4	1.0	-0.1	-0.3	-0.3	0.0	0.8	-1.0	-0.9
Eye problems/disorders: None of the above	0.3	0.4	2.2	-1.5	0.2	0.2	0.0	-0.2	0.2	-0.7
Mean time to correctly identify matches	0.3	0.6	2.1	0.8	0.8	0.6	0.8	0.0	-0.1	-1.4
Leg fat mass (right)	0.3	1.1	6.4	2.5	0.1	0.1	0.5	0.7	0.2	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	2.1	-0.3	-0.0	-0.3	-0.4	-0.1	0.3	1.4
Hearing aid user	0.3	0.3	1.6	-1.3	-0.4	-0.2	-0.5	0.2	-0.1	0.3
Medication: Paracetamol	0.3	0.4	1.2	-1.1	0.6	0.6	0.6	-0.5	0.7	0.3
Ever smoked	0.3	0.5	1.1	-0.3	-0.8	-0.6	-0.7	1.1	-0.9	-0.0
Arm fat-free mass (left)	0.3	1.8	3.2	1.7	-1.2	-1.4	-0.6	1.8	-1.6	-0.4
Ever depressed for a whole week	0.3	0.4	1.5	-0.4	-0.2	-0.3	-0.2	1.2	-0.8	0.3
Leg fat mass (left)	0.3	1.0	6.2	2.5	0.1	0.0	0.5	0.5	0.3	-0.6
Arm predicted mass (left)	0.3	1.4	2.6	1.4	-1.0	-1.2	-0.4	1.6	-1.5	-0.7
Neuroticism (Nagel 2018)	0.2	0.6	0.7	0.5	-0.9	-0.8	-0.8	0.8	-0.8	-0.5
Schizophrenia vs Biploar Disorder	0.2	0.2	1.0	0.3	1.0	0.0	0.7	0.0	0.0	0.0
Alzheimer’s Disease (in mother)	0.2	0.2	0.7	-0.1	0.9	0.6	0.4	-0.2	0.3	0.1
Breast Cancer	0.2	0.5	0.8	0.7	0.9	0.8	0.9	-0.4	0.0	-0.6
Type 2 Diabetes (T2D) (2012)	0.2	0.3	1.8	0.0	0.0	0.0	-1.3	0.0	0.0	0.0
BMI	0.2	0.9	5.9	2.4	0.1	0.1	0.4	0.0	0.5	0.1
Smoking Status	0.2	0.4	1.9	1.4	0.1	-0.0	-0.2	-0.4	0.4	-0.5
Hearing difficulty/problems: Yes	0.2	0.3	1.0	-0.5	0.1	-0.0	0.1	0.6	-1.0	-0.6
Angina	0.2	0.2	0.5	0.5	0.7	0.6	0.4	-0.2	0.2	-0.4
Vitamin and mineral supplements	0.2	0.3	1.1	0.1	-0.3	-0.2	-0.1	1.0	-1.0	-0.2
Medication: Co-codamol	0.2	0.3	1.5	1.2	-0.0	-0.2	0.3	0.1	-0.3	0.2
Maternal smoking around birth	0.2	0.2	1.5	1.2	0.2	-0.1	0.2	-0.4	0.0	-0.1
Fed-up feelings	0.2	0.3	2.2	1.5	0.1	-0.1	-0.1	-0.3	0.2	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.3	0.7	0.4	0.7	0.5	0.7	0.6	-0.1	-0.8
Financial difficulties in last 2 years	0.2	0.3	0.6	0.7	-0.5	-0.7	-0.8	-0.0	-0.1	0.4
Heart attack	0.2	0.3	1.0	1.0	0.5	0.3	0.4	-0.4	0.5	-0.4
Hip circumference	0.2	0.7	2.6	1.6	-0.4	-0.5	0.3	1.2	-0.6	-0.5
Happiness	0.2	0.3	0.9	-0.3	-0.1	0.0	-0.1	0.7	-0.9	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.9	-0.5	-0.1	-0.0	-0.1	0.8	-1.0	0.0
Mouth/teeth dental problems: Dentures	0.2	0.3	0.7	-0.7	0.1	-0.1	0.2	0.6	-0.8	-0.8
Medication: Cholesterol lowering	0.2	0.4	0.8	-0.7	-0.6	-0.7	-0.9	0.5	-0.4	0.4
Depression (self-reported)	0.2	0.2	1.2	-1.1	-0.2	-0.1	-0.1	0.5	-0.3	0.3
Arm fat mass (right)	0.2	0.7	3.2	1.8	-0.4	-0.4	0.0	1.0	-0.3	-0.1
Glaucoma (self-reported)	0.2	0.3	1.2	-1.1	-0.4	-0.4	-0.3	-0.1	0.1	0.5
Number of children fathered	0.2	0.2	0.8	0.1	0.4	0.2	-0.0	-0.7	0.9	-0.4
Medication for pain relief, constipation, heartburn	0.2	0.3	1.0	0.3	0.2	0.4	0.2	-1.0	0.6	-0.9
Angina (self-reported)	0.2	0.2	0.5	0.4	0.7	0.6	0.4	-0.2	0.1	-0.5
Medication: Seretide 50 evohaler	0.2	0.2	0.3	-0.5	-0.5	-0.6	-0.5	0.1	-0.2	0.3
Whole body fat mass	0.2	1.0	4.2	2.0	-0.7	-0.7	-0.2	1.2	-0.4	0.1
Arm predicted mass (right)	0.2	1.0	1.8	1.3	-0.7	-0.9	-0.1	1.3	-1.1	-0.8
Family relationship satisfaction	0.2	0.2	0.4	-0.5	-0.4	-0.3	-0.2	0.2	-0.7	-0.6
Supplements: Vitamin C	0.2	0.3	0.7	-0.8	0.6	0.5	0.6	-0.1	-0.1	-0.6
Average weekly red wine intake	0.2	0.3	0.9	-1.0	-0.4	-0.5	-0.5	0.6	-0.4	0.3
Mood swings	0.2	0.4	1.6	1.3	0.1	-0.2	-0.2	-0.6	0.8	-0.3
Loneliness, isolation	0.2	0.3	0.6	0.5	-0.6	-0.7	-0.8	0.2	-0.3	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.6	1.2	0.2	0.2	0.2	-0.7	0.7	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.7	0.1	0.2	-0.2	-0.1	-0.8	0.8	0.7
Osteoporosis (self-reported)	0.2	0.3	0.6	0.3	-0.5	-0.8	-0.6	0.7	-0.3	0.5
Number of operations (self-reported)	0.2	0.2	0.5	-0.5	0.6	0.3	0.6	0.7	-0.4	0.3
Average weekly beer plus cider intake	0.2	0.3	0.7	0.8	-0.5	-0.2	-0.5	0.3	-0.0	0.7
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.5	-0.6	-0.4	-0.3	-0.3	0.7	-0.4	0.7
Reaction Time	0.1	0.2	0.6	0.8	0.2	0.0	0.3	0.5	-0.6	-0.6
Blood Eosinophil Count	0.1	1.1	1.5	1.2	-1.1	-1.2	-0.7	1.2	-0.7	1.2
Cardiovascular Disease	0.1	0.3	0.6	0.5	-0.2	-0.2	-0.5	0.8	-0.4	0.8
Chronotype (morning person)	0.1	0.3	1.3	-1.1	-0.6	-0.5	-0.4	0.1	-0.1	0.1
Tanning	0.1	0.7	2.2	0.7	0.3	-0.0	-0.0	-1.5	1.3	0.5
Average weekly spirits intake	0.1	0.2	0.5	0.2	0.3	0.2	0.2	-0.7	0.6	-0.5
Sensitivity / hurt feelings	0.1	0.2	0.5	-0.6	-0.6	-0.5	-0.7	0.4	-0.3	0.0
Impedance of leg (right)	0.1	0.2	0.9	-0.2	0.5	0.5	0.0	-0.5	1.0	0.1
Trunk fat percentage	0.1	0.4	1.6	1.3	-0.5	-0.6	-0.3	0.8	-0.1	0.4
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.5	-0.1	-0.4	-0.0	0.3	-0.5	0.1
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	-0.1	0.6	0.4	0.4	-0.3	0.5	-0.0
Impedance of leg (left)	0.1	0.3	0.9	-0.3	0.3	0.2	-0.3	-0.6	1.0	0.6
Trunk fat mass	0.1	0.6	2.4	1.5	-0.5	-0.6	-0.1	1.1	-0.4	-0.2
Had other major operations	0.1	0.1	0.4	-0.1	0.3	0.2	0.0	-0.3	0.6	0.6
Neuroticism score	0.1	0.2	0.4	0.6	-0.4	-0.6	-0.7	0.0	0.1	-0.0
Arm fat percentage (right)	0.1	0.4	2.0	1.4	-0.3	-0.2	0.0	0.6	0.2	0.3
Lung cancer (father)	0.1	0.2	0.2	0.3	-0.5	-0.4	-0.3	0.4	-0.5	0.5
Body fat percentage	0.1	0.5	3.0	1.7	-0.0	-0.0	0.2	0.4	0.6	0.2
Number of full brothers	0.1	0.1	0.3	-0.1	-0.0	-0.2	-0.0	0.6	-0.5	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.4	-0.1	-0.0	-0.0	0.2	0.5	-0.7	-0.3
Qualifications: College or University degree	0.1	0.4	1.5	-0.3	-0.3	-0.1	-0.1	0.8	-1.2	-0.7
Neck or shoulder pain in last month	0.1	0.1	0.2	0.3	-0.2	-0.2	-0.4	-0.1	-0.2	0.4
Migraine (self-reported)	0.1	0.2	0.5	0.7	0.1	0.2	0.2	-0.2	0.6	0.4
Medication: Omeprazole	0.1	0.2	0.4	-0.7	-0.2	-0.0	-0.2	0.5	-0.1	0.6
Alcohol intake frequency.	0.1	0.3	1.1	0.2	0.3	0.1	0.5	0.8	-1.1	-0.5
Suffer from ‘nerves’	0.1	0.2	0.4	-0.5	-0.7	-0.6	-0.5	0.1	-0.2	-0.4
Arm fat percentage (left)	0.1	0.3	1.8	1.4	-0.2	-0.1	0.2	0.4	0.3	0.3
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.1	0.3	0.2	0.4	0.4	0.2	-0.3	-0.3
Friendships satisfaction	0.1	0.2	0.5	0.2	-0.4	-0.4	-0.2	0.5	-0.7	0.3
Qualifications: nursing, teaching	0.1	0.1	0.5	-0.2	0.4	0.7	0.3	0.2	0.2	0.4
Arm fat mass (left)	0.1	0.6	2.3	1.5	-0.5	-0.6	-0.0	1.0	-0.4	0.0
Medication: Lisinopril	0.1	0.2	0.5	0.3	-0.2	-0.0	-0.1	-0.2	0.7	0.7
Age started oral contraceptive pill	0.1	0.1	0.3	0.5	-0.3	-0.4	-0.4	0.5	-0.1	0.2
Unable to work because of sickness or disability	0.1	0.1	0.6	0.1	0.3	0.2	0.3	-0.0	-0.2	-0.8
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.9	1.0	0.3	0.1	0.2	-0.2	0.3	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.4	0.7	0.9	-0.9	-0.7	-0.8	-0.4	0.2	0.3
Relative age of first facial hair	0.0	0.1	0.3	0.3	0.1	-0.3	-0.2	-0.4	0.5	0.1
Relative age voice broke	0.0	0.0	0.1	-0.0	0.0	0.0	0.1	0.1	0.3	0.2

Hub : Genes

RCN3

Models

Trait associations