Hub : Genes

RCN3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.2290	0.0910	9.7e-03	0.019	NA	-0.008	NA	0.020	7.8e-02	NA	7.3e-01	NA	7.2e-02
2	GTEx	Colon Transverse	0.1760	0.0670	3.4e-03	0.102	NA	0.034	NA	0.062	1.4e-05	NA	9.8e-03	NA	6.8e-04
3	GTEx	Whole Blood	0.1800	0.0470	6.0e-06	0.118	NA	0.069	NA	0.104	5.0e-11	NA	6.0e-07	NA	7.4e-10
4	YFS	Blood	0.1747	0.0269	0.0e+00	0.124	0.102	0.124	0.132	0.124	1.5e-38	1.7e-31	2.5e-38	8e-41	2.7e-38
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0252	0.0160	2.8e-03	0.014	0.017	0.010	NA	0.012	9.5e-03	4.7e-03	2.3e-02	NA	1.6e-02
6	TCGA	Brain Lower Grade Glioma	0.0195	0.0128	5.1e-03	0.006	0.013	0.004	NA	0.004	6.6e-02	1.1e-02	9.0e-02	NA	9.4e-02
7	TCGA	Prostate Adenocarcinoma	0.0555	0.0334	9.6e-03	-0.002	0.019	0.014	NA	0.002	5.6e-01	3.5e-03	1.2e-02	NA	2.1e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.5	2.4	3.9	0.2	1.9	1.9	2.0	-1.4	1.9	0.0
Bipolar Disorder or Schizophrenia	2.9	7.0	15.7	0.0	2.6	2.5	2.3	-3.8	4.0	-0.7
Depressed Affect (Nagel 2018)	0.3	0.6	3.7	1.9	-0.2	-0.4	-0.2	-0.2	-0.1	-0.6
Depression (Nagel 2018)	0.4	0.6	2.2	1.5	-0.3	-0.5	-0.4	-0.9	0.5	-0.2
Intelligence (Savage-Jansen 2018)	0.9	2.9	7.5	-2.0	-1.2	-1.1	-0.9	2.1	-2.7	-0.8
Neuroticism (Nagel 2018)	0.2	0.6	0.7	0.5	-0.9	-0.8	-0.8	0.8	-0.8	-0.5
Schizophrenia (2018)	2.7	5.5	13.7	-0.2	2.1	2.1	1.8	-3.7	3.5	-0.8
Schizophrenia vs Biploar Disorder	0.2	0.2	1.0	0.3	1.0	0.0	0.7	0.0	0.0	0.0
Worry (Nagel 2018)	0.4	0.8	1.3	-0.5	-1.1	-1.1	-1.0	1.1	-1.0	-0.1
Alzheimer’s Disease (in mother)	0.2	0.2	0.7	-0.1	0.9	0.6	0.4	-0.2	0.3	0.1
Alzheimer’s Disease (in father)	0.8	0.8	3.9	-2.0	0.3	0.6	0.1	-0.9	0.8	0.2
Alzheimer’s Disease (including proxy)	1.1	1.6	2.9	-1.2	1.7	1.4	1.1	-1.4	1.3	-0.5
Crohns Disease (2017)	3.0	6.7	10.5	-0.2	-3.2	-3.2	-3.2	2.6	-2.6	1.4
Irritable Bowel Disease (IBD)	0.4	1.0	2.7	-1.6	-0.9	-0.8	-0.9	0.5	-1.0	-1.0
Ulcerative Colitis (UC)	1.4	2.6	5.9	-1.9	1.4	1.4	1.2	-1.4	0.9	-2.4
Major Depression (MDD)	1.0	1.2	2.2	0.6	-1.5	-1.3	-1.2	1.0	-1.1	0.8
Reaction Time	0.1	0.2	0.6	0.8	0.2	0.0	0.3	0.5	-0.6	-0.6
Verbal and Numeric Reasoning (VNR)	0.8	1.9	4.9	-0.9	-1.1	-0.9	-0.5	1.7	-2.2	-1.5
Breast Cancer	0.2	0.5	0.8	0.7	0.9	0.8	0.9	-0.4	0.0	-0.6
Ovarian Cancer	0.8	1.1	2.9	0.4	0.6	0.7	0.9	-1.7	1.5	-0.9
Prostate Cancer	1.7	2.4	4.6	1.0	-1.5	-1.7	-1.4	2.1	-2.0	0.7
Age at First Birth	2.1	3.1	5.3	-0.7	-2.0	-2.2	-2.3	1.2	-0.8	2.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.6	2.1	-0.2	1.0	1.1	1.5	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.9	1.5	2.3	-0.5	-1.4	-1.5	-1.4	1.4	-1.0	1.1
Mean Putamen Volume	0.3	0.4	0.8	-0.9	-0.5	-0.0	-0.2	0.8	-0.9	0.4
Fasting Glucose	0.5	0.6	2.8	1.7	0.6	0.3	0.5	-0.5	0.7	-0.3
HbA1C	0.6	0.7	1.2	-1.1	0.8	0.9	1.1	-0.5	-0.0	-0.9
HDL Cholesterol	1.2	2.0	2.9	-1.7	-1.3	-1.5	-1.5	1.2	-1.0	1.6
LDL Cholesterol	5.2	8.3	12.5	-2.1	-3.1	-2.7	-2.7	3.5	-3.4	2.3
Lupus	2.8	4.2	6.2	0.9	2.0	2.0	2.2	-2.5	2.4	-1.8
Neuroticism (2016)	0.4	0.6	1.1	-0.4	-0.7	-1.0	-0.5	1.0	-1.1	-0.1
Primary Biliary Cirrhosis	1.0	1.4	3.4	-0.2	-1.4	-1.1	-0.9	1.8	-1.5	0.4
Rheumatoid Arthritis	1.0	1.3	3.7	-1.1	1.3	1.3	1.9	0.0	-0.0	-1.0
Schizophrenia (2014)	2.8	6.2	14.3	-0.6	2.3	2.5	2.1	-3.8	3.5	-0.4
Triglycerides	4.4	7.1	12.2	0.4	-2.9	-2.7	-2.7	3.5	-3.5	1.7
Type 2 Diabetes (T2D) (2012)	0.2	0.3	1.8	0.0	0.0	0.0	-1.3	0.0	0.0	0.0
Ulcerative Colitis	2.0	2.9	6.7	-1.2	1.8	1.7	1.5	-1.6	1.2	-2.6
Blood Eosinophil Count	0.1	1.1	1.5	1.2	-1.1	-1.2	-0.7	1.2	-0.7	1.2
Blood Platelet Count	1.9	22.3	39.1	-1.6	-5.0	-4.7	-4.4	6.2	-6.1	3.2
Blood Red Count	7.0	67.2	144.0	1.4	-8.3	-8.3	-7.7	12.0	-10.4	4.3
Blood White Count	0.6	4.7	8.2	1.8	-2.2	-1.9	-1.6	2.9	-2.7	1.8
Heel T-Score	0.3	2.1	3.7	-1.4	1.8	1.7	1.9	-0.1	0.4	-1.5
BMI	0.2	0.9	5.9	2.4	0.1	0.1	0.4	0.0	0.5	0.1
Height	0.5	10.0	23.4	-1.8	-2.6	-3.1	-1.9	4.2	-4.8	-2.3
Waist Hip Ratio (WHR)	2.0	8.9	14.2	1.7	-3.0	-3.0	-3.1	3.8	-3.1	2.8
Systolic Blood Pressure	0.8	4.2	10.4	1.0	1.9	2.1	1.5	-2.8	3.2	-0.1
Smoking Status	0.2	0.4	1.9	1.4	0.1	-0.0	-0.2	-0.4	0.4	-0.5
Allergy or Eczema	2.7	7.2	19.7	0.5	-2.4	-2.5	-1.8	3.9	-4.4	0.3
Cardiovascular Disease	0.1	0.3	0.6	0.5	-0.2	-0.2	-0.5	0.8	-0.4	0.8
Hypothyroidism (self reported)	3.1	7.1	14.1	-0.1	3.0	2.9	2.5	-3.5	3.8	-0.4
Respiratory disease	0.4	1.0	2.5	-0.8	0.5	0.4	1.0	1.4	-1.6	-0.4
Type 2 Diabetes (T2D) (2018)	2.4	4.6	7.0	1.9	-2.2	-2.2	-1.9	2.6	-2.6	0.9
Lung FEV1/FVC ratio	1.1	5.6	11.7	0.3	2.2	2.1	1.6	-3.4	3.3	-2.1
Lung FVC	0.3	1.6	4.1	-2.0	-0.8	-0.9	-0.7	1.4	-1.2	1.3
Neuroticism	0.7	1.6	2.9	0.7	-1.5	-1.7	-1.6	1.2	-1.2	0.4
Chronotype (morning person)	0.1	0.3	1.3	-1.1	-0.6	-0.5	-0.4	0.1	-0.1	0.1
Hair Pigment	0.0	0.4	0.7	0.9	-0.9	-0.7	-0.8	-0.4	0.2	0.3
Tanning	0.1	0.7	2.2	0.7	0.3	-0.0	-0.0	-1.5	1.3	0.5
Hand grip strength (left)	0.4	1.1	2.4	0.0	0.9	0.8	0.8	-1.6	1.6	0.8
Number of treatments/medications taken	0.6	1.1	2.5	-1.6	1.2	1.3	1.2	-0.1	0.5	-0.4
Average weekly spirits intake	0.1	0.2	0.5	0.2	0.3	0.2	0.2	-0.7	0.6	-0.5
Sensitivity / hurt feelings	0.1	0.2	0.5	-0.6	-0.6	-0.5	-0.7	0.4	-0.3	0.0
Frequency of depressed mood in last 2 weeks	1.4	2.0	3.7	0.6	-1.8	-1.8	-1.9	0.6	-0.8	1.4
Hearing difficulty/problems: Yes	0.2	0.3	1.0	-0.5	0.1	-0.0	0.1	0.6	-1.0	-0.6
Relative age of first facial hair	0.0	0.1	0.3	0.3	0.1	-0.3	-0.2	-0.4	0.5	0.1
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.9	-0.9	1.5	1.1	1.7	0.1	0.2	-1.1
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.1	1.1	-0.5	-0.7	-0.6	0.2	0.3	0.7
Ever had hysterectomy (womb removed)	2.1	2.3	3.4	-0.7	1.8	1.8	1.7	-1.3	1.5	-1.6
Systolic blood pressure, automated reading	1.9	5.4	13.8	-0.5	2.3	2.4	2.0	-3.0	3.7	-0.5
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.3	1.1	-0.7	-0.6	-0.6	0.4	-1.0	-0.3
Angina	0.2	0.2	0.5	0.5	0.7	0.6	0.4	-0.2	0.2	-0.4
Medication for hormone replacement therapy	0.9	1.0	1.6	-0.9	1.3	1.2	0.9	-0.9	1.1	-0.7
Vitamin and mineral supplements	0.2	0.3	1.1	0.1	-0.3	-0.2	-0.1	1.0	-1.0	-0.2
Supplements: Zinc	0.9	1.0	3.4	1.8	0.7	0.6	0.7	-0.8	0.4	-1.1
Medication: Co-codamol	0.2	0.3	1.5	1.2	-0.0	-0.2	0.3	0.1	-0.3	0.2
Medication: Metformin	0.9	1.2	3.3	1.8	-0.5	-0.5	-0.4	1.5	-1.4	-0.1
Diabetes (father)	2.0	2.5	5.9	0.1	-1.6	-1.6	-1.2	2.1	-2.4	0.8
Diabetes (mother)	1.1	1.3	3.3	0.4	-1.3	-1.1	-0.9	1.8	-1.4	0.6
Severe depression (siblings)	0.4	0.4	1.1	-1.0	0.0	0.0	0.2	1.0	-0.9	-0.2
Pack years adult smoking proportion	1.1	1.7	8.8	3.0	-0.8	-1.0	-0.9	-0.0	-0.6	0.5
Impedance of leg (right)	0.1	0.2	0.9	-0.2	0.5	0.5	0.0	-0.5	1.0	0.1
Leg fat-free mass (left)	0.6	3.4	7.6	0.8	-1.9	-1.9	-1.2	2.6	-2.7	-0.5
Trunk fat percentage	0.1	0.4	1.6	1.3	-0.5	-0.6	-0.3	0.8	-0.1	0.4
Hand grip strength (right)	0.3	0.9	2.7	0.2	0.3	0.3	0.3	-1.2	1.2	1.6
Townsend deprivation index at recruitment	0.3	0.5	1.3	1.1	0.4	0.6	0.5	0.5	-0.3	-0.9
Current tobacco smoking	1.7	2.9	7.3	2.7	1.4	1.2	1.1	-1.8	1.6	-1.5
Average weekly fortified wine intake	1.6	1.8	4.9	0.8	-1.2	-1.0	-0.8	2.2	-1.8	1.1
Maternal smoking around birth	0.2	0.2	1.5	1.2	0.2	-0.1	0.2	-0.4	0.0	-0.1
Fed-up feelings	0.2	0.3	2.2	1.5	0.1	-0.1	-0.1	-0.3	0.2	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	3.6	1.9	-0.1	-0.3	-0.3	-1.0	0.5	-1.1
Relative age voice broke	0.0	0.0	0.1	-0.0	0.0	0.0	0.1	0.1	0.3	0.2
Taking other prescription medications	1.3	2.1	4.6	-1.4	1.8	1.8	2.1	-0.6	0.9	-0.7
Age when periods started (menarche)	1.2	2.8	6.2	-1.8	1.5	1.3	1.2	-2.2	2.5	0.5
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.9	-0.8	-0.4	-0.6	-0.4	0.9	-1.0	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.3	0.7	0.4	0.7	0.5	0.7	0.6	-0.1	-0.8
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.5	0.4	0.4	0.3	0.6	-0.7	0.5	-0.7
Qualifications: CSEs or equivalent	1.5	1.9	3.5	-0.4	-1.5	-1.7	-1.7	1.2	-0.8	1.9
Serious illness, injury or assault to yourself	2.3	2.8	3.7	-0.4	1.9	1.9	1.9	-1.7	1.7	-1.7
High blood pressure	1.1	3.2	4.7	1.2	2.1	2.0	1.9	-1.7	2.2	-1.0
Hayfever, allergic rhinitis or eczema	2.6	5.7	13.9	0.2	-2.3	-2.5	-2.0	3.1	-3.7	0.9
Multivitamins +/- minerals	0.7	0.9	2.9	-0.1	0.7	0.8	0.6	-1.7	1.3	-0.7
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.5	-0.1	-0.4	-0.0	0.3	-0.5	0.1
Supplements: Glucosamine	0.3	0.4	1.2	0.0	0.6	0.6	0.5	-0.9	1.1	-0.2
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	3.4	0.4	1.7	1.5	1.6	-1.7	1.8	-0.5
Medication: Atenolol	0.8	0.9	1.7	0.1	1.2	1.3	1.1	-0.9	1.2	-0.2
Medication: Levothyroxine sodium	4.1	7.0	12.2	-1.1	3.1	2.8	2.6	-3.4	3.5	-0.6
Sitting height	0.8	5.9	11.4	-1.0	-2.4	-2.6	-2.1	3.4	-3.4	-1.1
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	-0.1	0.6	0.4	0.4	-0.3	0.5	-0.0
High blood pressure (mother)	1.4	1.9	4.6	0.3	1.1	1.2	0.8	-2.0	2.1	-1.1
Body mass index (BMI)	0.3	1.3	5.6	2.4	0.7	0.7	1.1	-0.4	1.1	-0.5
Impedance of leg (left)	0.1	0.3	0.9	-0.3	0.3	0.2	-0.3	-0.6	1.0	0.6
Leg predicted mass (left)	0.7	3.5	7.7	0.7	-1.9	-1.9	-1.2	2.6	-2.8	-0.5
Trunk fat mass	0.1	0.6	2.4	1.5	-0.5	-0.6	-0.1	1.1	-0.4	-0.2
Waist circumference	0.5	1.6	5.1	2.2	-1.0	-1.0	-0.6	1.7	-0.9	0.6
Number of incorrect matches in round	0.3	0.4	1.9	1.4	0.5	0.6	0.5	-0.4	0.2	0.1
Past tobacco smoking	1.2	2.1	4.5	0.7	1.5	1.3	1.4	-2.1	1.8	-0.8
Alcohol usually taken with meals	1.2	1.9	8.7	-3.0	-0.8	-0.7	-0.6	1.1	-1.3	-0.2
Nervous feelings	0.3	0.6	1.4	-1.1	-0.7	-0.7	-0.4	1.2	-0.8	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.1	-0.3	-0.9	-0.6	-0.9	0.9	-1.1	0.4
Hearing difficulty/problems with background noise	0.5	0.7	1.9	-0.3	1.0	0.9	1.1	-0.3	0.2	-1.4
Hair/balding pattern: Pattern 2	1.8	2.3	3.6	0.3	1.6	1.5	1.4	-1.7	1.6	-1.9
Had menopause	0.4	0.5	0.9	0.9	0.4	0.2	0.2	-0.9	0.9	-0.9
Had other major operations	0.1	0.1	0.4	-0.1	0.3	0.2	0.0	-0.3	0.6	0.6
Forced vital capacity (FVC)	1.8	7.1	11.3	-2.3	-2.7	-2.7	-2.4	3.4	-3.3	1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.6	-1.0	0.9	0.8	0.8	0.0	0.4	-1.2
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	2.2	0.2	-1.5	-1.5	-1.2	1.4	-1.3	0.8
Qualifications: None of the above	0.6	1.3	2.6	-0.8	1.0	1.2	1.0	-1.5	1.6	-0.3
Financial difficulties in last 2 years	0.2	0.3	0.6	0.7	-0.5	-0.7	-0.8	-0.0	-0.1	0.4
Mouth/teeth dental problems	0.5	0.8	1.2	-0.9	-1.0	-0.8	-1.1	0.9	-1.1	0.4
Heart attack	0.2	0.3	1.0	1.0	0.5	0.3	0.4	-0.4	0.5	-0.4
Allergy	2.0	4.5	15.0	0.2	1.5	1.6	0.9	-3.3	3.9	0.0
Pain all over the body in last month	0.4	0.4	1.1	-0.2	1.0	0.7	1.1	0.4	0.1	0.3
Diabetes (self-reported)	0.9	1.3	5.0	2.2	-0.9	-0.9	-0.7	1.0	-1.0	0.6
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	4.1	0.4	-1.0	-1.1	-0.9	1.8	-2.0	1.0
Medication: Ramipril	0.6	0.8	5.0	2.2	0.1	-0.2	-0.2	0.2	-0.3	-0.4
Medication: Simvastatin	0.8	1.2	1.8	-0.9	-1.0	-1.3	-1.4	1.3	-1.0	0.2
Fluid intelligence score	1.3	2.7	5.5	-1.1	-1.7	-1.8	-1.4	2.0	-2.3	-0.6
Illnesses of siblings	4.0	5.7	9.8	0.6	-3.1	-3.0	-3.1	1.6	-2.4	1.6
Neuroticism score	0.1	0.2	0.4	0.6	-0.4	-0.6	-0.7	0.0	0.1	-0.0
Weight	0.3	1.4	3.2	1.6	-1.0	-1.1	-0.4	1.8	-1.3	-0.5
Impedance of arm (right)	1.1	5.3	9.0	-3.0	-2.2	-2.0	-2.5	2.3	-2.5	1.1
Arm fat percentage (right)	0.1	0.4	2.0	1.4	-0.3	-0.2	0.0	0.6	0.2	0.3
Trunk fat-free mass	0.3	1.6	3.5	0.7	-1.0	-1.1	-0.3	1.8	-1.9	-1.2
Hip circumference	0.2	0.7	2.6	1.6	-0.4	-0.5	0.3	1.2	-0.6	-0.5
Time employed in main current job	0.5	0.6	3.4	-1.8	0.4	0.3	0.1	-0.2	0.6	0.1
Alcohol intake versus 10 years previously	0.8	1.3	2.3	0.1	1.5	1.2	1.3	-1.1	1.2	-0.7
Father’s age at death	0.3	0.3	0.7	0.4	0.6	0.4	0.6	-0.7	0.8	-0.6
Worrier / anxious feelings	0.5	1.0	3.4	-0.7	-0.4	-0.5	-0.1	1.9	-1.4	-0.6
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	5.6	2.3	-1.5	-1.6	-1.4	1.9	-2.4	-0.7
Falls in the last year	0.3	0.4	2.3	1.5	-0.4	-0.5	-0.6	-0.2	-0.1	0.2
Hair/balding pattern: Pattern 3	0.9	1.4	2.2	1.2	-1.3	-1.5	-1.4	1.1	-0.8	0.8
Number of live births	0.7	1.0	3.0	-0.8	-0.6	-0.7	-0.5	1.7	-1.4	0.7
Forced expiratory volume in 1-second (FEV1)	1.4	4.6	6.6	-2.6	-2.2	-2.2	-2.0	2.2	-2.3	1.2
Pulse rate	0.3	0.6	3.1	1.8	-0.3	-0.8	-0.1	-0.4	0.0	-0.1
Happiness	0.2	0.3	0.9	-0.3	-0.1	0.0	-0.1	0.7	-0.9	-0.6
Noisy workplace	1.0	1.2	4.6	2.1	1.0	0.6	0.8	-0.7	0.5	-1.1
Qualifications: A levels/AS levels or equivalent	0.5	1.0	2.8	0.6	-1.0	-0.7	-0.9	1.2	-1.7	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.9	-0.5	-0.1	-0.0	-0.1	0.8	-1.0	0.0
Mouth/teeth dental problems: Dentures	0.2	0.3	0.7	-0.7	0.1	-0.1	0.2	0.6	-0.8	-0.8
Asthma	0.7	1.4	5.0	-0.2	-0.4	-0.3	0.2	2.0	-2.2	0.4
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	3.6	0.2	-1.3	-1.3	-1.2	1.9	-1.9	1.1
Medication: Cholesterol lowering	0.2	0.4	0.8	-0.7	-0.6	-0.7	-0.9	0.5	-0.4	0.4
Depression (self-reported)	0.2	0.2	1.2	-1.1	-0.2	-0.1	-0.1	0.5	-0.3	0.3
Medication: Lansoprazole	0.4	0.4	1.0	0.4	0.8	0.7	0.7	-0.4	1.0	0.3
Prospective memory result	0.5	0.6	1.3	1.0	0.0	-0.1	0.1	-1.0	1.1	1.1
Lung cancer (father)	0.1	0.2	0.2	0.3	-0.5	-0.4	-0.3	0.4	-0.5	0.5
Illnesses of mother	3.1	3.8	9.3	0.8	-1.9	-2.1	-1.5	2.5	-3.1	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.0	5.1	-2.3	-1.8	-1.9	-1.8	1.6	-1.7	0.7
Pulse wave Arterial Stiffness index	0.9	1.1	2.2	0.2	-1.1	-1.2	-0.8	1.0	-0.9	1.5
Impedance of arm (left)	1.1	5.0	12.0	-3.5	-2.0	-1.8	-2.4	1.9	-2.1	1.4
Arm fat mass (right)	0.2	0.7	3.2	1.8	-0.4	-0.4	0.0	1.0	-0.3	-0.1
Trunk predicted mass	0.3	1.7	3.8	0.7	-1.1	-1.2	-0.4	1.9	-1.9	-1.1
Standing height	1.0	10.3	20.6	-1.6	-3.2	-3.5	-2.8	4.3	-4.5	-0.7
Length of working week for main job	0.5	0.6	1.1	-0.6	1.0	0.9	0.8	-0.5	0.8	-0.5
Exposure to tobacco smoke at home	1.9	2.2	3.6	1.6	-1.8	-1.8	-1.9	0.7	-0.8	1.1
Breastfed as a baby	0.8	1.0	3.2	1.8	-0.9	-1.0	-0.9	0.8	-0.8	0.0
Tense / ‘highly strung’	1.3	2.2	6.1	-0.2	1.3	1.3	0.8	-2.2	2.5	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	1.6	0.4	1.2	1.2	1.1	-1.0	1.3	-0.3
Hair/balding pattern: Pattern 4	1.2	3.0	8.0	0.5	-1.6	-1.4	-1.1	2.8	-2.2	1.5
Birth weight of first child	1.2	2.3	3.8	1.6	-1.8	-1.6	-1.9	-0.1	-0.1	1.9
Peak expiratory flow (PEF)	0.9	2.2	6.3	-2.5	-1.2	-1.2	-0.9	1.6	-1.7	0.2
Pulse wave reflection index	0.9	1.1	1.7	0.3	-1.2	-1.0	-1.0	1.3	-1.3	0.9
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.3	1.1	-0.3	-0.3	-0.1	0.7	-1.2	-1.0
Loud music exposure frequency	3.6	4.0	6.3	-1.3	-2.5	-2.5	-2.3	1.6	-1.5	1.9
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	5.5	-2.4	-1.0	-0.8	-0.9	1.8	-1.5	0.1
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	2.6	-0.9	1.4	1.4	1.3	-1.4	1.6	-0.9
Blood clot in the leg (DVT)	1.3	1.7	4.8	-0.7	-0.8	-0.8	-0.1	2.2	-2.2	-0.9
Medication: Paracetamol	0.6	0.9	1.9	-0.3	1.0	1.1	0.9	-1.1	1.4	0.3
Headache pain in last month	2.2	3.7	6.6	0.4	-2.1	-2.0	-1.8	2.6	-2.0	2.0
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	3.0	0.0	-1.5	-1.4	-1.0	1.4	-1.7	0.5
Glaucoma (self-reported)	0.2	0.3	1.2	-1.1	-0.4	-0.4	-0.3	-0.1	0.1	0.5
Gout (self-reported)	0.6	0.9	2.9	0.8	-0.8	-0.9	-1.0	0.6	0.0	1.7
Hypothyroidism/myxoedema (self-reported)	6.2	12.2	19.4	-0.8	4.1	3.8	3.6	-4.3	4.4	-1.6
Medication: Amlodipine	1.9	2.6	4.5	0.2	2.1	1.7	1.8	-1.7	2.1	-0.6
Medication: Ventolin 100micrograms inhaler	2.0	2.6	4.7	-1.3	1.8	1.7	2.2	-1.0	0.2	-2.1
Birth weight	0.3	0.6	1.8	-1.4	0.1	0.5	0.2	-0.4	0.2	-1.4
Chronic bronchitis/emphysema (mother)	2.1	2.4	4.5	0.4	1.7	1.7	1.8	-1.5	1.1	-2.1
High blood pressure (siblings)	1.1	1.6	2.9	-0.7	1.7	1.6	1.7	-0.4	1.3	-0.9
Forced vital capacity (FVC), Best measure	1.3	4.7	6.3	-2.3	-2.2	-2.2	-2.1	2.5	-2.5	1.0
Body fat percentage	0.1	0.5	3.0	1.7	-0.0	-0.0	0.2	0.4	0.6	0.2
Leg fat percentage (right)	0.5	1.8	5.9	2.4	1.1	1.1	1.4	-0.1	1.4	-0.6
Arm fat-free mass (right)	0.3	1.4	2.5	1.6	-1.0	-1.2	-0.4	1.6	-1.5	-0.5
Exposure to tobacco smoke outside home	3.6	4.7	8.6	-0.9	-2.3	-2.4	-2.2	2.9	-2.5	1.3
Comparative body size at age 10	0.3	0.9	2.1	-0.6	-0.6	-0.7	-0.5	1.4	-1.4	-1.1
Number of full brothers	0.1	0.1	0.3	-0.1	-0.0	-0.2	-0.0	0.6	-0.5	0.0
Worry too long after embarrassment	0.8	1.3	2.5	-1.6	-1.1	-0.9	-1.0	1.2	-1.4	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.4	-0.1	-0.0	-0.0	0.2	0.5	-0.7	-0.3
Wheeze or whistling in the chest in last year	2.4	4.3	8.8	0.4	-1.8	-1.7	-1.4	3.0	-2.9	2.0
Number of children fathered	0.2	0.2	0.8	0.1	0.4	0.2	-0.0	-0.7	0.9	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	3.1	-1.8	0.7	0.5	0.4	-0.4	1.2	0.7
Age at first live birth	1.7	3.1	5.3	1.4	1.7	1.7	1.6	-2.3	2.3	-1.0
Pulse wave peak to peak time	0.7	0.9	2.5	-0.5	1.0	1.0	0.7	-0.7	0.7	-1.6
Health satisfaction	0.3	0.4	1.7	0.4	0.5	0.3	0.5	0.1	-0.4	-1.3
Shortness of breath walking on level ground	0.3	0.4	1.0	-0.1	-0.3	-0.3	0.0	0.8	-1.0	-0.9
Qualifications: College or University degree	0.1	0.4	1.5	-0.3	-0.3	-0.1	-0.1	0.8	-1.2	-0.7
Eye problems/disorders: None of the above	0.3	0.4	2.2	-1.5	0.2	0.2	0.0	-0.2	0.2	-0.7
Mouth/teeth dental problems: Loose teeth	0.8	1.0	1.9	1.4	1.0	0.8	1.2	-0.3	0.5	-1.3
Emphysema/chronic bronchitis	0.6	0.6	1.0	1.0	0.7	0.6	0.9	1.0	-0.6	-0.7
Medication for pain relief, constipation, heartburn	0.2	0.3	1.0	0.3	0.2	0.4	0.2	-1.0	0.6	-0.9
Neck or shoulder pain in last month	0.1	0.1	0.2	0.3	-0.2	-0.2	-0.4	-0.1	-0.2	0.4
Medication: Blood pressure	3.0	5.3	9.4	1.1	2.7	2.4	2.1	-2.7	3.1	-1.3
Angina (self-reported)	0.2	0.2	0.5	0.4	0.7	0.6	0.4	-0.2	0.1	-0.5
Migraine (self-reported)	0.1	0.2	0.5	0.7	0.1	0.2	0.2	-0.2	0.6	0.4
Medication: Ibuprofen	1.9	2.2	3.9	0.6	-1.5	-1.4	-1.4	2.0	-1.9	1.3
Medication: Allopurinol	0.5	0.7	2.3	0.6	-0.8	-0.7	-0.8	0.5	-0.2	1.5
Medication: Omeprazole	0.1	0.2	0.4	-0.7	-0.2	-0.0	-0.2	0.5	-0.1	0.6
Medication: Seretide 50 evohaler	0.2	0.2	0.3	-0.5	-0.5	-0.6	-0.5	0.1	-0.2	0.3
Mean time to correctly identify matches	0.3	0.6	2.1	0.8	0.8	0.6	0.8	0.0	-0.1	-1.4
Heart disease (mother)	1.5	1.8	2.7	0.9	1.5	1.6	1.6	-0.9	1.3	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.5	1.0	0.3	0.9	0.6	1.0	-0.6	0.8	-0.8
Whole body fat mass	0.2	1.0	4.2	2.0	-0.7	-0.7	-0.2	1.2	-0.4	0.1
Leg fat mass (right)	0.3	1.1	6.4	2.5	0.1	0.1	0.5	0.7	0.2	-0.6
Arm predicted mass (right)	0.2	1.0	1.8	1.3	-0.7	-0.9	-0.1	1.3	-1.1	-0.8
Pulse rate, automated reading	0.5	1.6	6.1	2.5	-0.5	-1.0	-0.4	-0.8	1.3	1.0
Alcohol intake frequency.	0.1	0.3	1.1	0.2	0.3	0.1	0.5	0.8	-1.1	-0.5
Comparative height size at age 10	1.6	8.7	19.3	-0.5	-2.9	-3.1	-2.4	4.2	-4.4	-0.4
Number of full sisters	0.4	0.5	1.7	-1.3	-0.4	-0.1	-0.4	0.6	-0.8	0.8
Suffer from ‘nerves’	0.1	0.2	0.4	-0.5	-0.7	-0.6	-0.5	0.1	-0.2	-0.4
Overall health rating	0.4	1.0	3.0	1.7	-0.1	-0.4	0.1	1.2	-1.3	-0.6
Chest pain or discomfort	0.5	0.8	2.2	1.1	-0.3	-0.6	-0.4	1.2	-1.5	0.3
Had major operations	2.4	2.8	3.5	-0.6	-1.9	-1.7	-1.7	1.8	-1.7	1.9
Age at last live birth	3.0	4.4	5.9	2.4	2.2	2.2	2.4	-1.8	1.6	-1.8
Family relationship satisfaction	0.2	0.2	0.4	-0.5	-0.4	-0.3	-0.2	0.2	-0.7	-0.6
Leg pain on walking	0.6	0.8	1.4	-1.1	0.7	0.6	1.1	0.5	-0.7	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	2.1	-0.3	-0.0	-0.3	-0.4	-0.1	0.3	1.4
Commuting to job workplace: Car/motor vehicle	0.9	1.0	4.2	0.3	-1.0	-0.9	-1.1	0.2	0.2	2.0
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.2	-0.5	-1.3	-1.2	-1.1	1.7	-1.8	0.8
Medication: Aspirin	0.6	0.8	1.6	-0.7	-0.7	-0.9	-0.7	1.3	-1.1	0.7
Supplements: Vitamin C	0.2	0.3	0.7	-0.8	0.6	0.5	0.6	-0.1	-0.1	-0.6
Knee pain experienced in last month	1.7	2.6	3.9	0.2	2.0	1.8	1.9	-1.6	1.5	-1.7
Hypertension (Self-reported)	1.1	3.0	4.4	1.4	2.1	1.9	1.8	-1.7	2.1	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.8	3.2	-1.2	-1.2	-1.3	-1.4	1.5	-1.0	1.8
Illnesses of father: Heart disease	1.8	2.5	6.8	0.2	-1.2	-1.3	-1.0	2.6	-2.0	1.6
Illnesses of siblings: Diabetes	0.4	0.5	0.9	-0.2	1.0	0.9	1.0	0.5	-0.2	-0.6
Smoking status: Previous	2.4	3.6	6.4	-1.2	-2.0	-1.8	-1.8	2.5	-2.2	1.5
Forced expiratory volume in 1-second (FEV1), predicted	1.4	3.0	5.6	0.1	-1.9	-1.9	-1.6	2.2	-2.4	0.1
Whole body fat-free mass	0.4	2.2	4.8	0.8	-1.4	-1.5	-0.7	2.1	-2.2	-0.8
Leg fat-free mass (right)	0.7	3.9	8.4	0.5	-2.1	-2.2	-1.5	2.6	-2.9	-0.2
Arm fat percentage (left)	0.1	0.3	1.8	1.4	-0.2	-0.1	0.2	0.4	0.3	0.3
Average weekly red wine intake	0.2	0.3	0.9	-1.0	-0.4	-0.5	-0.5	0.6	-0.4	0.3
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.1	0.3	0.2	0.4	0.4	0.2	-0.3	-0.3
Mood swings	0.2	0.4	1.6	1.3	0.1	-0.2	-0.2	-0.6	0.8	-0.3
Loneliness, isolation	0.2	0.3	0.6	0.5	-0.6	-0.7	-0.8	0.2	-0.3	-0.7
Long-standing illness, disability or infirmity	1.2	1.8	4.2	-0.3	1.6	1.4	2.1	0.3	-0.2	-1.9
Ever had bowel cancer screening	2.3	2.6	3.8	-0.7	1.9	1.6	1.9	-1.5	1.6	-1.9
Diabetes diagnosed by doctor	1.1	1.8	4.1	2.0	-1.1	-1.1	-0.9	1.6	-1.5	0.6
Ever had stillbirth, spontaneous miscarriage or termination	5.2	5.5	7.5	-0.3	2.7	2.6	2.5	-2.3	2.5	-2.6
Friendships satisfaction	0.1	0.2	0.5	0.2	-0.4	-0.4	-0.2	0.5	-0.7	0.3
Qualifications: nursing, teaching	0.1	0.1	0.5	-0.2	0.4	0.7	0.3	0.2	0.2	0.4
Commuting to job workplace: Walk	0.5	0.6	1.7	0.1	-0.2	-0.1	0.2	1.2	-1.3	-1.0
Eye problems/disorders: Cataract	0.8	0.9	2.4	-0.8	-0.7	-0.7	-0.3	1.6	-1.4	0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.6	1.2	0.2	0.2	0.2	-0.7	0.7	0.3
Medication for cholesterol	0.7	1.0	2.0	0.6	-1.4	-1.2	-1.2	0.3	-0.6	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.7	0.1	0.2	-0.2	-0.1	-0.8	0.8	0.7
Back pain experienced in last month	4.1	6.0	7.8	-1.0	2.8	2.6	2.8	-2.8	2.5	-2.3
Mineral and other dietary supplements	2.4	3.2	5.1	0.4	-2.0	-2.0	-1.8	1.9	-2.3	1.3
Breast cancer (self-reported)	2.5	3.0	4.6	-1.5	2.1	1.9	2.1	-1.3	1.7	-1.3
Asthma (self-reported)	0.6	1.2	4.3	-0.2	-0.4	-0.4	0.1	1.9	-2.1	0.5
Osteoporosis (self-reported)	0.2	0.3	0.6	0.3	-0.5	-0.8	-0.6	0.7	-0.3	0.5
Osteoarthritis (self-reported)	1.6	2.1	3.1	-1.7	1.7	1.6	1.8	-0.8	1.0	-1.0
Medication: Aspirin	0.4	0.6	1.1	-0.6	-0.6	-0.7	-0.7	1.1	-0.8	0.8
Medication: Gliclazide	2.1	2.4	5.2	2.3	-1.3	-1.7	-1.2	1.8	-1.6	-0.2
Illnesses of father: None of the above (group 1)	0.4	0.5	1.3	0.6	-1.1	-0.8	-1.0	-0.1	-0.2	0.2
Smoking status: Current	1.6	2.5	5.7	2.4	1.3	1.1	1.1	-1.6	1.5	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	5.2	-2.3	-0.5	-0.6	-0.7	0.5	-0.2	0.9
Whole body water mass	0.4	2.0	4.4	0.9	-1.3	-1.5	-0.7	2.0	-2.1	-0.9
Leg predicted mass (right)	0.7	3.8	8.4	0.5	-2.1	-2.2	-1.4	2.6	-2.9	-0.2
Arm fat mass (left)	0.1	0.6	2.3	1.5	-0.5	-0.6	-0.0	1.0	-0.4	0.0
Number of self-reported non-cancer illnesses	1.3	2.2	4.3	-1.2	2.1	2.0	2.0	-0.5	0.9	-0.7
Average weekly champagne plus white wine intake	0.4	0.5	1.1	0.9	-0.6	-0.7	-0.7	0.6	-1.0	-0.2
Miserableness	0.7	1.1	4.4	2.1	-0.6	-0.8	-0.7	0.5	-1.1	-0.8
Guilty feelings	0.9	1.4	3.7	-0.5	-1.1	-0.9	-1.1	1.9	-1.5	0.7
Wears glasses or contact lenses	0.5	0.6	3.3	-0.4	0.5	0.5	0.4	-0.3	0.2	-1.8
Ever taken oral contraceptive pill	0.9	1.0	3.9	2.0	-1.0	-0.9	-0.8	0.2	-0.8	-0.2
Hearing aid user	0.3	0.3	1.6	-1.3	-0.4	-0.2	-0.5	0.2	-0.1	0.3
Mother’s age at death	1.7	2.1	3.3	-1.8	1.4	1.4	0.9	-1.8	1.7	-0.9
Financial situation satisfaction	1.7	2.1	5.6	-0.2	-1.4	-1.4	-1.2	1.9	-2.4	-0.2
Tinnitus: Yes, now most or all of the time	1.3	1.5	3.1	-1.3	-0.7	-0.6	-0.5	1.8	-1.8	1.0
Commuting to job workplace: Public transport	0.5	0.6	1.5	-0.5	-0.8	-0.5	-0.7	1.1	-1.2	-0.5
Eye problems/disorders: Glaucoma	1.1	1.3	2.7	0.0	-1.5	-1.6	-1.5	0.7	-0.9	1.0
Medication: Blood pressure	0.4	0.8	1.8	0.6	1.3	1.0	1.3	0.4	0.3	-0.6
Pain type(s) experienced in last month: Hip pain	2.1	2.6	3.9	0.5	1.9	1.7	1.9	-1.1	1.6	-2.0
Supplements: Fish oil (including cod liver oil)	3.5	4.5	6.7	-1.2	2.6	2.5	2.3	-2.2	2.3	-1.3
High cholesterol (Self-reported)	2.7	4.8	7.0	-0.1	-2.5	-2.4	-2.5	2.6	-2.2	1.9
Medication: Bendroflumethiazide	1.3	2.0	4.3	-0.2	1.7	1.6	1.6	-0.8	1.0	-2.1
Medication: Paracetamol	0.3	0.4	1.2	-1.1	0.6	0.6	0.6	-0.5	0.7	0.3
Medication: Lisinopril	0.1	0.2	0.5	0.3	-0.2	-0.0	-0.1	-0.2	0.7	0.7
Medication: Atorvastatin	3.6	4.5	6.2	-0.6	-2.3	-2.5	-2.4	2.3	-2.5	1.7
Illnesses of father: High blood pressure	3.1	3.8	5.1	-0.5	2.3	2.2	2.0	-2.2	2.0	-2.0
Alcohol drinker status: Never	0.4	0.5	0.9	-0.9	-0.3	-0.4	-0.5	0.9	-0.4	1.0
Ever smoked	0.3	0.5	1.1	-0.3	-0.8	-0.6	-0.7	1.1	-0.9	-0.0
Basal metabolic rate	0.4	2.3	4.7	1.1	-1.4	-1.5	-0.7	2.2	-2.1	-0.7
Leg fat percentage (left)	0.5	1.6	5.5	2.3	1.0	1.0	1.2	-0.4	1.5	-0.4
Arm fat-free mass (left)	0.3	1.8	3.2	1.7	-1.2	-1.4	-0.6	1.8	-1.6	-0.4
Number of operations (self-reported)	0.2	0.2	0.5	-0.5	0.6	0.3	0.6	0.7	-0.4	0.3
Average weekly beer plus cider intake	0.2	0.3	0.7	0.8	-0.5	-0.2	-0.5	0.3	-0.0	0.7
Irritability	1.6	2.6	5.3	2.3	1.3	1.0	1.0	-1.9	2.2	-1.0
Risk taking	1.3	1.9	4.9	1.1	1.3	1.3	1.0	-1.7	2.2	0.3
Ever had prostate specific antigen (PSA) test	1.0	1.1	1.9	0.8	1.3	1.1	1.4	-0.8	0.9	-1.0
Fractured/broken bones in last 5 years	0.7	1.0	1.8	-1.3	0.7	0.6	0.5	-1.3	1.4	0.6
Age started oral contraceptive pill	0.1	0.1	0.3	0.5	-0.3	-0.4	-0.4	0.5	-0.1	0.2
Diastolic blood pressure, automated reading	0.8	2.6	8.4	0.1	1.2	1.2	1.2	-2.2	2.9	-0.3
Ever depressed for a whole week	0.3	0.4	1.5	-0.4	-0.2	-0.3	-0.2	1.2	-0.8	0.3
Unable to work because of sickness or disability	0.1	0.1	0.6	0.1	0.3	0.2	0.3	-0.0	-0.2	-0.8
Commuting to job workplace: Cycle	0.4	0.5	1.1	-0.6	-0.5	-0.8	-0.5	0.6	-1.1	-0.4
Myopia	1.0	1.4	4.4	-1.4	0.8	0.9	1.0	-0.8	0.5	-2.1
Vascular/heart problems diagnosed by doctor	1.6	4.2	6.6	-1.0	-2.6	-2.3	-2.2	2.1	-2.5	1.1
Cholesterol lowering medication	2.7	4.0	9.0	-1.4	-1.9	-1.9	-1.7	3.0	-2.5	0.9
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.5	-0.6	-0.4	-0.3	-0.3	0.7	-0.4	0.7
Pain experienced in last month	1.0	1.6	3.8	0.1	-1.5	-1.4	-1.9	0.8	-0.6	1.5
Supplements: Calcium	0.6	0.6	2.7	1.6	-0.5	-0.8	-0.7	-0.4	0.3	0.2
Basal cell carcinoma (self-reported)	0.8	1.0	3.8	-1.9	-0.7	-0.7	-0.2	0.9	-1.0	-0.2
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.9	1.0	0.3	0.1	0.2	-0.2	0.3	-0.2
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	5.2	-0.6	-1.0	-0.9	-0.2	2.2	-2.3	-0.7
Heart disease (siblings)	1.3	1.5	2.6	-0.6	1.6	1.4	1.6	-0.9	1.5	-0.5
Alcohol drinker status: Previous	0.6	0.7	1.5	-0.2	0.9	0.9	1.2	-0.1	-0.5	-1.2
Pack years of smoking	1.0	1.5	9.1	3.0	-0.5	-0.8	-0.6	-0.0	-0.5	0.4
Impedance of whole body	0.4	2.0	4.4	-2.1	-1.2	-1.1	-1.8	1.1	-1.0	1.3
Leg fat mass (left)	0.3	1.0	6.2	2.5	0.1	0.0	0.5	0.5	0.3	-0.6
Arm predicted mass (left)	0.3	1.4	2.6	1.4	-1.0	-1.2	-0.4	1.6	-1.5	-0.7