Hub : Genes

RCN3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells EBV-transformed lymphocytes 0.2290 0.0910 9.7e-03 0.019 NA -0.008 NA 0.020 7.8e-02 NA 7.3e-01 NA 7.2e-02
2 GTEx Colon Transverse 0.1760 0.0670 3.4e-03 0.102 NA 0.034 NA 0.062 1.4e-05 NA 9.8e-03 NA 6.8e-04
3 GTEx Whole Blood 0.1800 0.0470 6.0e-06 0.118 NA 0.069 NA 0.104 5.0e-11 NA 6.0e-07 NA 7.4e-10
4 YFS Blood 0.1747 0.0269 0.0e+00 0.124 0.102 0.124 0.132 0.124 1.5e-38 1.7e-31 2.5e-38 8e-41 2.7e-38
5 TCGA Kidney Renal Clear Cell Carcinoma 0.0252 0.0160 2.8e-03 0.014 0.017 0.010 NA 0.012 9.5e-03 4.7e-03 2.3e-02 NA 1.6e-02
6 TCGA Brain Lower Grade Glioma 0.0195 0.0128 5.1e-03 0.006 0.013 0.004 NA 0.004 6.6e-02 1.1e-02 9.0e-02 NA 9.4e-02
7 TCGA Prostate Adenocarcinoma 0.0555 0.0334 9.6e-03 -0.002 0.019 0.014 NA 0.002 5.6e-01 3.5e-03 1.2e-02 NA 2.1e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 1.5 2.4 3.9 0.2 1.9 1.9 2.0 -1.4 1.9 0.0
Bipolar Disorder or Schizophrenia 2.9 7.0 15.7 0.0 2.6 2.5 2.3 -3.8 4.0 -0.7
Depressed Affect (Nagel 2018) 0.3 0.6 3.7 1.9 -0.2 -0.4 -0.2 -0.2 -0.1 -0.6
Depression (Nagel 2018) 0.4 0.6 2.2 1.5 -0.3 -0.5 -0.4 -0.9 0.5 -0.2
Intelligence (Savage-Jansen 2018) 0.9 2.9 7.5 -2.0 -1.2 -1.1 -0.9 2.1 -2.7 -0.8
Neuroticism (Nagel 2018) 0.2 0.6 0.7 0.5 -0.9 -0.8 -0.8 0.8 -0.8 -0.5
Schizophrenia (2018) 2.7 5.5 13.7 -0.2 2.1 2.1 1.8 -3.7 3.5 -0.8
Schizophrenia vs Biploar Disorder 0.2 0.2 1.0 0.3 1.0 0.0 0.7 0.0 0.0 0.0
Worry (Nagel 2018) 0.4 0.8 1.3 -0.5 -1.1 -1.1 -1.0 1.1 -1.0 -0.1
Alzheimer’s Disease (in mother) 0.2 0.2 0.7 -0.1 0.9 0.6 0.4 -0.2 0.3 0.1
Alzheimer’s Disease (in father) 0.8 0.8 3.9 -2.0 0.3 0.6 0.1 -0.9 0.8 0.2
Alzheimer’s Disease (including proxy) 1.1 1.6 2.9 -1.2 1.7 1.4 1.1 -1.4 1.3 -0.5
Crohns Disease (2017) 3.0 6.7 10.5 -0.2 -3.2 -3.2 -3.2 2.6 -2.6 1.4
Irritable Bowel Disease (IBD) 0.4 1.0 2.7 -1.6 -0.9 -0.8 -0.9 0.5 -1.0 -1.0
Ulcerative Colitis (UC) 1.4 2.6 5.9 -1.9 1.4 1.4 1.2 -1.4 0.9 -2.4
Major Depression (MDD) 1.0 1.2 2.2 0.6 -1.5 -1.3 -1.2 1.0 -1.1 0.8
Reaction Time 0.1 0.2 0.6 0.8 0.2 0.0 0.3 0.5 -0.6 -0.6
Verbal and Numeric Reasoning (VNR) 0.8 1.9 4.9 -0.9 -1.1 -0.9 -0.5 1.7 -2.2 -1.5
Breast Cancer 0.2 0.5 0.8 0.7 0.9 0.8 0.9 -0.4 0.0 -0.6
Ovarian Cancer 0.8 1.1 2.9 0.4 0.6 0.7 0.9 -1.7 1.5 -0.9
Prostate Cancer 1.7 2.4 4.6 1.0 -1.5 -1.7 -1.4 2.1 -2.0 0.7
Age at First Birth 2.1 3.1 5.3 -0.7 -2.0 -2.2 -2.3 1.2 -0.8 2.3
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.5 0.6 2.1 -0.2 1.0 1.1 1.5 0.0 0.0 0.0
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.9 1.5 2.3 -0.5 -1.4 -1.5 -1.4 1.4 -1.0 1.1
Mean Putamen Volume 0.3 0.4 0.8 -0.9 -0.5 -0.0 -0.2 0.8 -0.9 0.4
Fasting Glucose 0.5 0.6 2.8 1.7 0.6 0.3 0.5 -0.5 0.7 -0.3
HbA1C 0.6 0.7 1.2 -1.1 0.8 0.9 1.1 -0.5 -0.0 -0.9
HDL Cholesterol 1.2 2.0 2.9 -1.7 -1.3 -1.5 -1.5 1.2 -1.0 1.6
LDL Cholesterol 5.2 8.3 12.5 -2.1 -3.1 -2.7 -2.7 3.5 -3.4 2.3
Lupus 2.8 4.2 6.2 0.9 2.0 2.0 2.2 -2.5 2.4 -1.8
Neuroticism (2016) 0.4 0.6 1.1 -0.4 -0.7 -1.0 -0.5 1.0 -1.1 -0.1
Primary Biliary Cirrhosis 1.0 1.4 3.4 -0.2 -1.4 -1.1 -0.9 1.8 -1.5 0.4
Rheumatoid Arthritis 1.0 1.3 3.7 -1.1 1.3 1.3 1.9 0.0 -0.0 -1.0
Schizophrenia (2014) 2.8 6.2 14.3 -0.6 2.3 2.5 2.1 -3.8 3.5 -0.4
Triglycerides 4.4 7.1 12.2 0.4 -2.9 -2.7 -2.7 3.5 -3.5 1.7
Type 2 Diabetes (T2D) (2012) 0.2 0.3 1.8 0.0 0.0 0.0 -1.3 0.0 0.0 0.0
Ulcerative Colitis 2.0 2.9 6.7 -1.2 1.8 1.7 1.5 -1.6 1.2 -2.6
Blood Eosinophil Count 0.1 1.1 1.5 1.2 -1.1 -1.2 -0.7 1.2 -0.7 1.2
Blood Platelet Count 1.9 22.3 39.1 -1.6 -5.0 -4.7 -4.4 6.2 -6.1 3.2
Blood Red Count 7.0 67.2 144.0 1.4 -8.3 -8.3 -7.7 12.0 -10.4 4.3
Blood White Count 0.6 4.7 8.2 1.8 -2.2 -1.9 -1.6 2.9 -2.7 1.8
Heel T-Score 0.3 2.1 3.7 -1.4 1.8 1.7 1.9 -0.1 0.4 -1.5
BMI 0.2 0.9 5.9 2.4 0.1 0.1 0.4 0.0 0.5 0.1
Height 0.5 10.0 23.4 -1.8 -2.6 -3.1 -1.9 4.2 -4.8 -2.3
Waist Hip Ratio (WHR) 2.0 8.9 14.2 1.7 -3.0 -3.0 -3.1 3.8 -3.1 2.8
Systolic Blood Pressure 0.8 4.2 10.4 1.0 1.9 2.1 1.5 -2.8 3.2 -0.1
Smoking Status 0.2 0.4 1.9 1.4 0.1 -0.0 -0.2 -0.4 0.4 -0.5
Allergy or Eczema 2.7 7.2 19.7 0.5 -2.4 -2.5 -1.8 3.9 -4.4 0.3
Cardiovascular Disease 0.1 0.3 0.6 0.5 -0.2 -0.2 -0.5 0.8 -0.4 0.8
Hypothyroidism (self reported) 3.1 7.1 14.1 -0.1 3.0 2.9 2.5 -3.5 3.8 -0.4
Respiratory disease 0.4 1.0 2.5 -0.8 0.5 0.4 1.0 1.4 -1.6 -0.4
Type 2 Diabetes (T2D) (2018) 2.4 4.6 7.0 1.9 -2.2 -2.2 -1.9 2.6 -2.6 0.9
Lung FEV1/FVC ratio 1.1 5.6 11.7 0.3 2.2 2.1 1.6 -3.4 3.3 -2.1
Lung FVC 0.3 1.6 4.1 -2.0 -0.8 -0.9 -0.7 1.4 -1.2 1.3
Neuroticism 0.7 1.6 2.9 0.7 -1.5 -1.7 -1.6 1.2 -1.2 0.4
Chronotype (morning person) 0.1 0.3 1.3 -1.1 -0.6 -0.5 -0.4 0.1 -0.1 0.1
Hair Pigment 0.0 0.4 0.7 0.9 -0.9 -0.7 -0.8 -0.4 0.2 0.3
Tanning 0.1 0.7 2.2 0.7 0.3 -0.0 -0.0 -1.5 1.3 0.5
Hand grip strength (left) 0.4 1.1 2.4 0.0 0.9 0.8 0.8 -1.6 1.6 0.8
Number of treatments/medications taken 0.6 1.1 2.5 -1.6 1.2 1.3 1.2 -0.1 0.5 -0.4
Average weekly spirits intake 0.1 0.2 0.5 0.2 0.3 0.2 0.2 -0.7 0.6 -0.5
Sensitivity / hurt feelings 0.1 0.2 0.5 -0.6 -0.6 -0.5 -0.7 0.4 -0.3 0.0
Frequency of depressed mood in last 2 weeks 1.4 2.0 3.7 0.6 -1.8 -1.8 -1.9 0.6 -0.8 1.4
Hearing difficulty/problems: Yes 0.2 0.3 1.0 -0.5 0.1 -0.0 0.1 0.6 -1.0 -0.6
Relative age of first facial hair 0.0 0.1 0.3 0.3 0.1 -0.3 -0.2 -0.4 0.5 0.1
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 2.9 -0.9 1.5 1.1 1.7 0.1 0.2 -1.1
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.1 1.1 -0.5 -0.7 -0.6 0.2 0.3 0.7
Ever had hysterectomy (womb removed) 2.1 2.3 3.4 -0.7 1.8 1.8 1.7 -1.3 1.5 -1.6
Systolic blood pressure, automated reading 1.9 5.4 13.8 -0.5 2.3 2.4 2.0 -3.0 3.7 -0.5
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 1.3 1.1 -0.7 -0.6 -0.6 0.4 -1.0 -0.3
Angina 0.2 0.2 0.5 0.5 0.7 0.6 0.4 -0.2 0.2 -0.4
Medication for hormone replacement therapy 0.9 1.0 1.6 -0.9 1.3 1.2 0.9 -0.9 1.1 -0.7
Vitamin and mineral supplements 0.2 0.3 1.1 0.1 -0.3 -0.2 -0.1 1.0 -1.0 -0.2
Supplements: Zinc 0.9 1.0 3.4 1.8 0.7 0.6 0.7 -0.8 0.4 -1.1
Medication: Co-codamol 0.2 0.3 1.5 1.2 -0.0 -0.2 0.3 0.1 -0.3 0.2
Medication: Metformin 0.9 1.2 3.3 1.8 -0.5 -0.5 -0.4 1.5 -1.4 -0.1
Diabetes (father) 2.0 2.5 5.9 0.1 -1.6 -1.6 -1.2 2.1 -2.4 0.8
Diabetes (mother) 1.1 1.3 3.3 0.4 -1.3 -1.1 -0.9 1.8 -1.4 0.6
Severe depression (siblings) 0.4 0.4 1.1 -1.0 0.0 0.0 0.2 1.0 -0.9 -0.2
Pack years adult smoking proportion 1.1 1.7 8.8 3.0 -0.8 -1.0 -0.9 -0.0 -0.6 0.5
Impedance of leg (right) 0.1 0.2 0.9 -0.2 0.5 0.5 0.0 -0.5 1.0 0.1
Leg fat-free mass (left) 0.6 3.4 7.6 0.8 -1.9 -1.9 -1.2 2.6 -2.7 -0.5
Trunk fat percentage 0.1 0.4 1.6 1.3 -0.5 -0.6 -0.3 0.8 -0.1 0.4
Hand grip strength (right) 0.3 0.9 2.7 0.2 0.3 0.3 0.3 -1.2 1.2 1.6
Townsend deprivation index at recruitment 0.3 0.5 1.3 1.1 0.4 0.6 0.5 0.5 -0.3 -0.9
Current tobacco smoking 1.7 2.9 7.3 2.7 1.4 1.2 1.1 -1.8 1.6 -1.5
Average weekly fortified wine intake 1.6 1.8 4.9 0.8 -1.2 -1.0 -0.8 2.2 -1.8 1.1
Maternal smoking around birth 0.2 0.2 1.5 1.2 0.2 -0.1 0.2 -0.4 0.0 -0.1
Fed-up feelings 0.2 0.3 2.2 1.5 0.1 -0.1 -0.1 -0.3 0.2 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 3.6 1.9 -0.1 -0.3 -0.3 -1.0 0.5 -1.1
Relative age voice broke 0.0 0.0 0.1 -0.0 0.0 0.0 0.1 0.1 0.3 0.2
Taking other prescription medications 1.3 2.1 4.6 -1.4 1.8 1.8 2.1 -0.6 0.9 -0.7
Age when periods started (menarche) 1.2 2.8 6.2 -1.8 1.5 1.3 1.2 -2.2 2.5 0.5
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 0.9 -0.8 -0.4 -0.6 -0.4 0.9 -1.0 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.3 0.7 0.4 0.7 0.5 0.7 0.6 -0.1 -0.8
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.5 0.4 0.4 0.3 0.6 -0.7 0.5 -0.7
Qualifications: CSEs or equivalent 1.5 1.9 3.5 -0.4 -1.5 -1.7 -1.7 1.2 -0.8 1.9
Serious illness, injury or assault to yourself 2.3 2.8 3.7 -0.4 1.9 1.9 1.9 -1.7 1.7 -1.7
High blood pressure 1.1 3.2 4.7 1.2 2.1 2.0 1.9 -1.7 2.2 -1.0
Hayfever, allergic rhinitis or eczema 2.6 5.7 13.9 0.2 -2.3 -2.5 -2.0 3.1 -3.7 0.9
Multivitamins +/- minerals 0.7 0.9 2.9 -0.1 0.7 0.8 0.6 -1.7 1.3 -0.7
Stomach or abdominal pain in last month 0.1 0.1 0.2 -0.5 -0.1 -0.4 -0.0 0.3 -0.5 0.1
Supplements: Glucosamine 0.3 0.4 1.2 0.0 0.6 0.6 0.5 -0.9 1.1 -0.2
Diverticular disease/diverticulitis (self-reported) 1.7 2.0 3.4 0.4 1.7 1.5 1.6 -1.7 1.8 -0.5
Medication: Atenolol 0.8 0.9 1.7 0.1 1.2 1.3 1.1 -0.9 1.2 -0.2
Medication: Levothyroxine sodium 4.1 7.0 12.2 -1.1 3.1 2.8 2.6 -3.4 3.5 -0.6
Sitting height 0.8 5.9 11.4 -1.0 -2.4 -2.6 -2.1 3.4 -3.4 -1.1
Chronic bronchitis/emphysema (father) 0.1 0.1 0.3 -0.1 0.6 0.4 0.4 -0.3 0.5 -0.0
High blood pressure (mother) 1.4 1.9 4.6 0.3 1.1 1.2 0.8 -2.0 2.1 -1.1
Body mass index (BMI) 0.3 1.3 5.6 2.4 0.7 0.7 1.1 -0.4 1.1 -0.5
Impedance of leg (left) 0.1 0.3 0.9 -0.3 0.3 0.2 -0.3 -0.6 1.0 0.6
Leg predicted mass (left) 0.7 3.5 7.7 0.7 -1.9 -1.9 -1.2 2.6 -2.8 -0.5
Trunk fat mass 0.1 0.6 2.4 1.5 -0.5 -0.6 -0.1 1.1 -0.4 -0.2
Waist circumference 0.5 1.6 5.1 2.2 -1.0 -1.0 -0.6 1.7 -0.9 0.6
Number of incorrect matches in round 0.3 0.4 1.9 1.4 0.5 0.6 0.5 -0.4 0.2 0.1
Past tobacco smoking 1.2 2.1 4.5 0.7 1.5 1.3 1.4 -2.1 1.8 -0.8
Alcohol usually taken with meals 1.2 1.9 8.7 -3.0 -0.8 -0.7 -0.6 1.1 -1.3 -0.2
Nervous feelings 0.3 0.6 1.4 -1.1 -0.7 -0.7 -0.4 1.2 -0.8 -0.3
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.1 -0.3 -0.9 -0.6 -0.9 0.9 -1.1 0.4
Hearing difficulty/problems with background noise 0.5 0.7 1.9 -0.3 1.0 0.9 1.1 -0.3 0.2 -1.4
Hair/balding pattern: Pattern 2 1.8 2.3 3.6 0.3 1.6 1.5 1.4 -1.7 1.6 -1.9
Had menopause 0.4 0.5 0.9 0.9 0.4 0.2 0.2 -0.9 0.9 -0.9
Had other major operations 0.1 0.1 0.4 -0.1 0.3 0.2 0.0 -0.3 0.6 0.6
Forced vital capacity (FVC) 1.8 7.1 11.3 -2.3 -2.7 -2.7 -2.4 3.4 -3.3 1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.6 -1.0 0.9 0.8 0.8 0.0 0.4 -1.2
Ever unenthusiastic/disinterested for a whole week 1.2 1.5 2.2 0.2 -1.5 -1.5 -1.2 1.4 -1.3 0.8
Qualifications: None of the above 0.6 1.3 2.6 -0.8 1.0 1.2 1.0 -1.5 1.6 -0.3
Financial difficulties in last 2 years 0.2 0.3 0.6 0.7 -0.5 -0.7 -0.8 -0.0 -0.1 0.4
Mouth/teeth dental problems 0.5 0.8 1.2 -0.9 -1.0 -0.8 -1.1 0.9 -1.1 0.4
Heart attack 0.2 0.3 1.0 1.0 0.5 0.3 0.4 -0.4 0.5 -0.4
Allergy 2.0 4.5 15.0 0.2 1.5 1.6 0.9 -3.3 3.9 0.0
Pain all over the body in last month 0.4 0.4 1.1 -0.2 1.0 0.7 1.1 0.4 0.1 0.3
Diabetes (self-reported) 0.9 1.3 5.0 2.2 -0.9 -0.9 -0.7 1.0 -1.0 0.6
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 4.1 0.4 -1.0 -1.1 -0.9 1.8 -2.0 1.0
Medication: Ramipril 0.6 0.8 5.0 2.2 0.1 -0.2 -0.2 0.2 -0.3 -0.4
Medication: Simvastatin 0.8 1.2 1.8 -0.9 -1.0 -1.3 -1.4 1.3 -1.0 0.2
Fluid intelligence score 1.3 2.7 5.5 -1.1 -1.7 -1.8 -1.4 2.0 -2.3 -0.6
Illnesses of siblings 4.0 5.7 9.8 0.6 -3.1 -3.0 -3.1 1.6 -2.4 1.6
Neuroticism score 0.1 0.2 0.4 0.6 -0.4 -0.6 -0.7 0.0 0.1 -0.0
Weight 0.3 1.4 3.2 1.6 -1.0 -1.1 -0.4 1.8 -1.3 -0.5
Impedance of arm (right) 1.1 5.3 9.0 -3.0 -2.2 -2.0 -2.5 2.3 -2.5 1.1
Arm fat percentage (right) 0.1 0.4 2.0 1.4 -0.3 -0.2 0.0 0.6 0.2 0.3
Trunk fat-free mass 0.3 1.6 3.5 0.7 -1.0 -1.1 -0.3 1.8 -1.9 -1.2
Hip circumference 0.2 0.7 2.6 1.6 -0.4 -0.5 0.3 1.2 -0.6 -0.5
Time employed in main current job 0.5 0.6 3.4 -1.8 0.4 0.3 0.1 -0.2 0.6 0.1
Alcohol intake versus 10 years previously 0.8 1.3 2.3 0.1 1.5 1.2 1.3 -1.1 1.2 -0.7
Father’s age at death 0.3 0.3 0.7 0.4 0.6 0.4 0.6 -0.7 0.8 -0.6
Worrier / anxious feelings 0.5 1.0 3.4 -0.7 -0.4 -0.5 -0.1 1.9 -1.4 -0.6
Frequency of tiredness / lethargy in last 2 weeks 1.9 3.1 5.6 2.3 -1.5 -1.6 -1.4 1.9 -2.4 -0.7
Falls in the last year 0.3 0.4 2.3 1.5 -0.4 -0.5 -0.6 -0.2 -0.1 0.2
Hair/balding pattern: Pattern 3 0.9 1.4 2.2 1.2 -1.3 -1.5 -1.4 1.1 -0.8 0.8
Number of live births 0.7 1.0 3.0 -0.8 -0.6 -0.7 -0.5 1.7 -1.4 0.7
Forced expiratory volume in 1-second (FEV1) 1.4 4.6 6.6 -2.6 -2.2 -2.2 -2.0 2.2 -2.3 1.2
Pulse rate 0.3 0.6 3.1 1.8 -0.3 -0.8 -0.1 -0.4 0.0 -0.1
Happiness 0.2 0.3 0.9 -0.3 -0.1 0.0 -0.1 0.7 -0.9 -0.6
Noisy workplace 1.0 1.2 4.6 2.1 1.0 0.6 0.8 -0.7 0.5 -1.1
Qualifications: A levels/AS levels or equivalent 0.5 1.0 2.8 0.6 -1.0 -0.7 -0.9 1.2 -1.7 -0.7
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 0.9 -0.5 -0.1 -0.0 -0.1 0.8 -1.0 0.0
Mouth/teeth dental problems: Dentures 0.2 0.3 0.7 -0.7 0.1 -0.1 0.2 0.6 -0.8 -0.8
Asthma 0.7 1.4 5.0 -0.2 -0.4 -0.3 0.2 2.0 -2.2 0.4
Medication: Ibuprofen (e.g. Nurofen) 1.5 1.9 3.6 0.2 -1.3 -1.3 -1.2 1.9 -1.9 1.1
Medication: Cholesterol lowering 0.2 0.4 0.8 -0.7 -0.6 -0.7 -0.9 0.5 -0.4 0.4
Depression (self-reported) 0.2 0.2 1.2 -1.1 -0.2 -0.1 -0.1 0.5 -0.3 0.3
Medication: Lansoprazole 0.4 0.4 1.0 0.4 0.8 0.7 0.7 -0.4 1.0 0.3
Prospective memory result 0.5 0.6 1.3 1.0 0.0 -0.1 0.1 -1.0 1.1 1.1
Lung cancer (father) 0.1 0.2 0.2 0.3 -0.5 -0.4 -0.3 0.4 -0.5 0.5
Illnesses of mother 3.1 3.8 9.3 0.8 -1.9 -2.1 -1.5 2.5 -3.1 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.0 5.1 -2.3 -1.8 -1.9 -1.8 1.6 -1.7 0.7
Pulse wave Arterial Stiffness index 0.9 1.1 2.2 0.2 -1.1 -1.2 -0.8 1.0 -0.9 1.5
Impedance of arm (left) 1.1 5.0 12.0 -3.5 -2.0 -1.8 -2.4 1.9 -2.1 1.4
Arm fat mass (right) 0.2 0.7 3.2 1.8 -0.4 -0.4 0.0 1.0 -0.3 -0.1
Trunk predicted mass 0.3 1.7 3.8 0.7 -1.1 -1.2 -0.4 1.9 -1.9 -1.1
Standing height 1.0 10.3 20.6 -1.6 -3.2 -3.5 -2.8 4.3 -4.5 -0.7
Length of working week for main job 0.5 0.6 1.1 -0.6 1.0 0.9 0.8 -0.5 0.8 -0.5
Exposure to tobacco smoke at home 1.9 2.2 3.6 1.6 -1.8 -1.8 -1.9 0.7 -0.8 1.1
Breastfed as a baby 0.8 1.0 3.2 1.8 -0.9 -1.0 -0.9 0.8 -0.8 0.0
Tense / ‘highly strung’ 1.3 2.2 6.1 -0.2 1.3 1.3 0.8 -2.2 2.5 -0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.0 1.6 0.4 1.2 1.2 1.1 -1.0 1.3 -0.3
Hair/balding pattern: Pattern 4 1.2 3.0 8.0 0.5 -1.6 -1.4 -1.1 2.8 -2.2 1.5
Birth weight of first child 1.2 2.3 3.8 1.6 -1.8 -1.6 -1.9 -0.1 -0.1 1.9
Peak expiratory flow (PEF) 0.9 2.2 6.3 -2.5 -1.2 -1.2 -0.9 1.6 -1.7 0.2
Pulse wave reflection index 0.9 1.1 1.7 0.3 -1.2 -1.0 -1.0 1.3 -1.3 0.9
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.3 1.1 -0.3 -0.3 -0.1 0.7 -1.2 -1.0
Loud music exposure frequency 3.6 4.0 6.3 -1.3 -2.5 -2.5 -2.3 1.6 -1.5 1.9
Qualifications: O levels/GCSEs or equivalent 1.2 1.9 5.5 -2.4 -1.0 -0.8 -0.9 1.8 -1.5 0.1
Mouth/teeth dental problems: Bleeding gums 1.3 1.7 2.6 -0.9 1.4 1.4 1.3 -1.4 1.6 -0.9
Blood clot in the leg (DVT) 1.3 1.7 4.8 -0.7 -0.8 -0.8 -0.1 2.2 -2.2 -0.9
Medication: Paracetamol 0.6 0.9 1.9 -0.3 1.0 1.1 0.9 -1.1 1.4 0.3
Headache pain in last month 2.2 3.7 6.6 0.4 -2.1 -2.0 -1.8 2.6 -2.0 2.0
Medication for cholesterol, blood pressure or diabetes 0.9 1.5 3.0 0.0 -1.5 -1.4 -1.0 1.4 -1.7 0.5
Glaucoma (self-reported) 0.2 0.3 1.2 -1.1 -0.4 -0.4 -0.3 -0.1 0.1 0.5
Gout (self-reported) 0.6 0.9 2.9 0.8 -0.8 -0.9 -1.0 0.6 0.0 1.7
Hypothyroidism/myxoedema (self-reported) 6.2 12.2 19.4 -0.8 4.1 3.8 3.6 -4.3 4.4 -1.6
Medication: Amlodipine 1.9 2.6 4.5 0.2 2.1 1.7 1.8 -1.7 2.1 -0.6
Medication: Ventolin 100micrograms inhaler 2.0 2.6 4.7 -1.3 1.8 1.7 2.2 -1.0 0.2 -2.1
Birth weight 0.3 0.6 1.8 -1.4 0.1 0.5 0.2 -0.4 0.2 -1.4
Chronic bronchitis/emphysema (mother) 2.1 2.4 4.5 0.4 1.7 1.7 1.8 -1.5 1.1 -2.1
High blood pressure (siblings) 1.1 1.6 2.9 -0.7 1.7 1.6 1.7 -0.4 1.3 -0.9
Forced vital capacity (FVC), Best measure 1.3 4.7 6.3 -2.3 -2.2 -2.2 -2.1 2.5 -2.5 1.0
Body fat percentage 0.1 0.5 3.0 1.7 -0.0 -0.0 0.2 0.4 0.6 0.2
Leg fat percentage (right) 0.5 1.8 5.9 2.4 1.1 1.1 1.4 -0.1 1.4 -0.6
Arm fat-free mass (right) 0.3 1.4 2.5 1.6 -1.0 -1.2 -0.4 1.6 -1.5 -0.5
Exposure to tobacco smoke outside home 3.6 4.7 8.6 -0.9 -2.3 -2.4 -2.2 2.9 -2.5 1.3
Comparative body size at age 10 0.3 0.9 2.1 -0.6 -0.6 -0.7 -0.5 1.4 -1.4 -1.1
Number of full brothers 0.1 0.1 0.3 -0.1 -0.0 -0.2 -0.0 0.6 -0.5 0.0
Worry too long after embarrassment 0.8 1.3 2.5 -1.6 -1.1 -0.9 -1.0 1.2 -1.4 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.4 -0.1 -0.0 -0.0 0.2 0.5 -0.7 -0.3
Wheeze or whistling in the chest in last year 2.4 4.3 8.8 0.4 -1.8 -1.7 -1.4 3.0 -2.9 2.0
Number of children fathered 0.2 0.2 0.8 0.1 0.4 0.2 -0.0 -0.7 0.9 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 3.1 -1.8 0.7 0.5 0.4 -0.4 1.2 0.7
Age at first live birth 1.7 3.1 5.3 1.4 1.7 1.7 1.6 -2.3 2.3 -1.0
Pulse wave peak to peak time 0.7 0.9 2.5 -0.5 1.0 1.0 0.7 -0.7 0.7 -1.6
Health satisfaction 0.3 0.4 1.7 0.4 0.5 0.3 0.5 0.1 -0.4 -1.3
Shortness of breath walking on level ground 0.3 0.4 1.0 -0.1 -0.3 -0.3 0.0 0.8 -1.0 -0.9
Qualifications: College or University degree 0.1 0.4 1.5 -0.3 -0.3 -0.1 -0.1 0.8 -1.2 -0.7
Eye problems/disorders: None of the above 0.3 0.4 2.2 -1.5 0.2 0.2 0.0 -0.2 0.2 -0.7
Mouth/teeth dental problems: Loose teeth 0.8 1.0 1.9 1.4 1.0 0.8 1.2 -0.3 0.5 -1.3
Emphysema/chronic bronchitis 0.6 0.6 1.0 1.0 0.7 0.6 0.9 1.0 -0.6 -0.7
Medication for pain relief, constipation, heartburn 0.2 0.3 1.0 0.3 0.2 0.4 0.2 -1.0 0.6 -0.9
Neck or shoulder pain in last month 0.1 0.1 0.2 0.3 -0.2 -0.2 -0.4 -0.1 -0.2 0.4
Medication: Blood pressure 3.0 5.3 9.4 1.1 2.7 2.4 2.1 -2.7 3.1 -1.3
Angina (self-reported) 0.2 0.2 0.5 0.4 0.7 0.6 0.4 -0.2 0.1 -0.5
Migraine (self-reported) 0.1 0.2 0.5 0.7 0.1 0.2 0.2 -0.2 0.6 0.4
Medication: Ibuprofen 1.9 2.2 3.9 0.6 -1.5 -1.4 -1.4 2.0 -1.9 1.3
Medication: Allopurinol 0.5 0.7 2.3 0.6 -0.8 -0.7 -0.8 0.5 -0.2 1.5
Medication: Omeprazole 0.1 0.2 0.4 -0.7 -0.2 -0.0 -0.2 0.5 -0.1 0.6
Medication: Seretide 50 evohaler 0.2 0.2 0.3 -0.5 -0.5 -0.6 -0.5 0.1 -0.2 0.3
Mean time to correctly identify matches 0.3 0.6 2.1 0.8 0.8 0.6 0.8 0.0 -0.1 -1.4
Heart disease (mother) 1.5 1.8 2.7 0.9 1.5 1.6 1.6 -0.9 1.3 -1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.5 1.0 0.3 0.9 0.6 1.0 -0.6 0.8 -0.8
Whole body fat mass 0.2 1.0 4.2 2.0 -0.7 -0.7 -0.2 1.2 -0.4 0.1
Leg fat mass (right) 0.3 1.1 6.4 2.5 0.1 0.1 0.5 0.7 0.2 -0.6
Arm predicted mass (right) 0.2 1.0 1.8 1.3 -0.7 -0.9 -0.1 1.3 -1.1 -0.8
Pulse rate, automated reading 0.5 1.6 6.1 2.5 -0.5 -1.0 -0.4 -0.8 1.3 1.0
Alcohol intake frequency. 0.1 0.3 1.1 0.2 0.3 0.1 0.5 0.8 -1.1 -0.5
Comparative height size at age 10 1.6 8.7 19.3 -0.5 -2.9 -3.1 -2.4 4.2 -4.4 -0.4
Number of full sisters 0.4 0.5 1.7 -1.3 -0.4 -0.1 -0.4 0.6 -0.8 0.8
Suffer from ‘nerves’ 0.1 0.2 0.4 -0.5 -0.7 -0.6 -0.5 0.1 -0.2 -0.4
Overall health rating 0.4 1.0 3.0 1.7 -0.1 -0.4 0.1 1.2 -1.3 -0.6
Chest pain or discomfort 0.5 0.8 2.2 1.1 -0.3 -0.6 -0.4 1.2 -1.5 0.3
Had major operations 2.4 2.8 3.5 -0.6 -1.9 -1.7 -1.7 1.8 -1.7 1.9
Age at last live birth 3.0 4.4 5.9 2.4 2.2 2.2 2.4 -1.8 1.6 -1.8
Family relationship satisfaction 0.2 0.2 0.4 -0.5 -0.4 -0.3 -0.2 0.2 -0.7 -0.6
Leg pain on walking 0.6 0.8 1.4 -1.1 0.7 0.6 1.1 0.5 -0.7 -1.2
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 2.1 -0.3 -0.0 -0.3 -0.4 -0.1 0.3 1.4
Commuting to job workplace: Car/motor vehicle 0.9 1.0 4.2 0.3 -1.0 -0.9 -1.1 0.2 0.2 2.0
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 3.2 -0.5 -1.3 -1.2 -1.1 1.7 -1.8 0.8
Medication: Aspirin 0.6 0.8 1.6 -0.7 -0.7 -0.9 -0.7 1.3 -1.1 0.7
Supplements: Vitamin C 0.2 0.3 0.7 -0.8 0.6 0.5 0.6 -0.1 -0.1 -0.6
Knee pain experienced in last month 1.7 2.6 3.9 0.2 2.0 1.8 1.9 -1.6 1.5 -1.7
Hypertension (Self-reported) 1.1 3.0 4.4 1.4 2.1 1.9 1.8 -1.7 2.1 -0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.6 1.8 3.2 -1.2 -1.2 -1.3 -1.4 1.5 -1.0 1.8
Illnesses of father: Heart disease 1.8 2.5 6.8 0.2 -1.2 -1.3 -1.0 2.6 -2.0 1.6
Illnesses of siblings: Diabetes 0.4 0.5 0.9 -0.2 1.0 0.9 1.0 0.5 -0.2 -0.6
Smoking status: Previous 2.4 3.6 6.4 -1.2 -2.0 -1.8 -1.8 2.5 -2.2 1.5
Forced expiratory volume in 1-second (FEV1), predicted 1.4 3.0 5.6 0.1 -1.9 -1.9 -1.6 2.2 -2.4 0.1
Whole body fat-free mass 0.4 2.2 4.8 0.8 -1.4 -1.5 -0.7 2.1 -2.2 -0.8
Leg fat-free mass (right) 0.7 3.9 8.4 0.5 -2.1 -2.2 -1.5 2.6 -2.9 -0.2
Arm fat percentage (left) 0.1 0.3 1.8 1.4 -0.2 -0.1 0.2 0.4 0.3 0.3
Average weekly red wine intake 0.2 0.3 0.9 -1.0 -0.4 -0.5 -0.5 0.6 -0.4 0.3
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.1 0.3 0.2 0.4 0.4 0.2 -0.3 -0.3
Mood swings 0.2 0.4 1.6 1.3 0.1 -0.2 -0.2 -0.6 0.8 -0.3
Loneliness, isolation 0.2 0.3 0.6 0.5 -0.6 -0.7 -0.8 0.2 -0.3 -0.7
Long-standing illness, disability or infirmity 1.2 1.8 4.2 -0.3 1.6 1.4 2.1 0.3 -0.2 -1.9
Ever had bowel cancer screening 2.3 2.6 3.8 -0.7 1.9 1.6 1.9 -1.5 1.6 -1.9
Diabetes diagnosed by doctor 1.1 1.8 4.1 2.0 -1.1 -1.1 -0.9 1.6 -1.5 0.6
Ever had stillbirth, spontaneous miscarriage or termination 5.2 5.5 7.5 -0.3 2.7 2.6 2.5 -2.3 2.5 -2.6
Friendships satisfaction 0.1 0.2 0.5 0.2 -0.4 -0.4 -0.2 0.5 -0.7 0.3
Qualifications: nursing, teaching 0.1 0.1 0.5 -0.2 0.4 0.7 0.3 0.2 0.2 0.4
Commuting to job workplace: Walk 0.5 0.6 1.7 0.1 -0.2 -0.1 0.2 1.2 -1.3 -1.0
Eye problems/disorders: Cataract 0.8 0.9 2.4 -0.8 -0.7 -0.7 -0.3 1.6 -1.4 0.6
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 1.6 1.2 0.2 0.2 0.2 -0.7 0.7 0.3
Medication for cholesterol 0.7 1.0 2.0 0.6 -1.4 -1.2 -1.2 0.3 -0.6 1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 0.7 0.1 0.2 -0.2 -0.1 -0.8 0.8 0.7
Back pain experienced in last month 4.1 6.0 7.8 -1.0 2.8 2.6 2.8 -2.8 2.5 -2.3
Mineral and other dietary supplements 2.4 3.2 5.1 0.4 -2.0 -2.0 -1.8 1.9 -2.3 1.3
Breast cancer (self-reported) 2.5 3.0 4.6 -1.5 2.1 1.9 2.1 -1.3 1.7 -1.3
Asthma (self-reported) 0.6 1.2 4.3 -0.2 -0.4 -0.4 0.1 1.9 -2.1 0.5
Osteoporosis (self-reported) 0.2 0.3 0.6 0.3 -0.5 -0.8 -0.6 0.7 -0.3 0.5
Osteoarthritis (self-reported) 1.6 2.1 3.1 -1.7 1.7 1.6 1.8 -0.8 1.0 -1.0
Medication: Aspirin 0.4 0.6 1.1 -0.6 -0.6 -0.7 -0.7 1.1 -0.8 0.8
Medication: Gliclazide 2.1 2.4 5.2 2.3 -1.3 -1.7 -1.2 1.8 -1.6 -0.2
Illnesses of father: None of the above (group 1) 0.4 0.5 1.3 0.6 -1.1 -0.8 -1.0 -0.1 -0.2 0.2
Smoking status: Current 1.6 2.5 5.7 2.4 1.3 1.1 1.1 -1.6 1.5 -1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 5.2 -2.3 -0.5 -0.6 -0.7 0.5 -0.2 0.9
Whole body water mass 0.4 2.0 4.4 0.9 -1.3 -1.5 -0.7 2.0 -2.1 -0.9
Leg predicted mass (right) 0.7 3.8 8.4 0.5 -2.1 -2.2 -1.4 2.6 -2.9 -0.2
Arm fat mass (left) 0.1 0.6 2.3 1.5 -0.5 -0.6 -0.0 1.0 -0.4 0.0
Number of self-reported non-cancer illnesses 1.3 2.2 4.3 -1.2 2.1 2.0 2.0 -0.5 0.9 -0.7
Average weekly champagne plus white wine intake 0.4 0.5 1.1 0.9 -0.6 -0.7 -0.7 0.6 -1.0 -0.2
Miserableness 0.7 1.1 4.4 2.1 -0.6 -0.8 -0.7 0.5 -1.1 -0.8
Guilty feelings 0.9 1.4 3.7 -0.5 -1.1 -0.9 -1.1 1.9 -1.5 0.7
Wears glasses or contact lenses 0.5 0.6 3.3 -0.4 0.5 0.5 0.4 -0.3 0.2 -1.8
Ever taken oral contraceptive pill 0.9 1.0 3.9 2.0 -1.0 -0.9 -0.8 0.2 -0.8 -0.2
Hearing aid user 0.3 0.3 1.6 -1.3 -0.4 -0.2 -0.5 0.2 -0.1 0.3
Mother’s age at death 1.7 2.1 3.3 -1.8 1.4 1.4 0.9 -1.8 1.7 -0.9
Financial situation satisfaction 1.7 2.1 5.6 -0.2 -1.4 -1.4 -1.2 1.9 -2.4 -0.2
Tinnitus: Yes, now most or all of the time 1.3 1.5 3.1 -1.3 -0.7 -0.6 -0.5 1.8 -1.8 1.0
Commuting to job workplace: Public transport 0.5 0.6 1.5 -0.5 -0.8 -0.5 -0.7 1.1 -1.2 -0.5
Eye problems/disorders: Glaucoma 1.1 1.3 2.7 0.0 -1.5 -1.6 -1.5 0.7 -0.9 1.0
Medication: Blood pressure 0.4 0.8 1.8 0.6 1.3 1.0 1.3 0.4 0.3 -0.6
Pain type(s) experienced in last month: Hip pain 2.1 2.6 3.9 0.5 1.9 1.7 1.9 -1.1 1.6 -2.0
Supplements: Fish oil (including cod liver oil) 3.5 4.5 6.7 -1.2 2.6 2.5 2.3 -2.2 2.3 -1.3
High cholesterol (Self-reported) 2.7 4.8 7.0 -0.1 -2.5 -2.4 -2.5 2.6 -2.2 1.9
Medication: Bendroflumethiazide 1.3 2.0 4.3 -0.2 1.7 1.6 1.6 -0.8 1.0 -2.1
Medication: Paracetamol 0.3 0.4 1.2 -1.1 0.6 0.6 0.6 -0.5 0.7 0.3
Medication: Lisinopril 0.1 0.2 0.5 0.3 -0.2 -0.0 -0.1 -0.2 0.7 0.7
Medication: Atorvastatin 3.6 4.5 6.2 -0.6 -2.3 -2.5 -2.4 2.3 -2.5 1.7
Illnesses of father: High blood pressure 3.1 3.8 5.1 -0.5 2.3 2.2 2.0 -2.2 2.0 -2.0
Alcohol drinker status: Never 0.4 0.5 0.9 -0.9 -0.3 -0.4 -0.5 0.9 -0.4 1.0
Ever smoked 0.3 0.5 1.1 -0.3 -0.8 -0.6 -0.7 1.1 -0.9 -0.0
Basal metabolic rate 0.4 2.3 4.7 1.1 -1.4 -1.5 -0.7 2.2 -2.1 -0.7
Leg fat percentage (left) 0.5 1.6 5.5 2.3 1.0 1.0 1.2 -0.4 1.5 -0.4
Arm fat-free mass (left) 0.3 1.8 3.2 1.7 -1.2 -1.4 -0.6 1.8 -1.6 -0.4
Number of operations (self-reported) 0.2 0.2 0.5 -0.5 0.6 0.3 0.6 0.7 -0.4 0.3
Average weekly beer plus cider intake 0.2 0.3 0.7 0.8 -0.5 -0.2 -0.5 0.3 -0.0 0.7
Irritability 1.6 2.6 5.3 2.3 1.3 1.0 1.0 -1.9 2.2 -1.0
Risk taking 1.3 1.9 4.9 1.1 1.3 1.3 1.0 -1.7 2.2 0.3
Ever had prostate specific antigen (PSA) test 1.0 1.1 1.9 0.8 1.3 1.1 1.4 -0.8 0.9 -1.0
Fractured/broken bones in last 5 years 0.7 1.0 1.8 -1.3 0.7 0.6 0.5 -1.3 1.4 0.6
Age started oral contraceptive pill 0.1 0.1 0.3 0.5 -0.3 -0.4 -0.4 0.5 -0.1 0.2
Diastolic blood pressure, automated reading 0.8 2.6 8.4 0.1 1.2 1.2 1.2 -2.2 2.9 -0.3
Ever depressed for a whole week 0.3 0.4 1.5 -0.4 -0.2 -0.3 -0.2 1.2 -0.8 0.3
Unable to work because of sickness or disability 0.1 0.1 0.6 0.1 0.3 0.2 0.3 -0.0 -0.2 -0.8
Commuting to job workplace: Cycle 0.4 0.5 1.1 -0.6 -0.5 -0.8 -0.5 0.6 -1.1 -0.4
Myopia 1.0 1.4 4.4 -1.4 0.8 0.9 1.0 -0.8 0.5 -2.1
Vascular/heart problems diagnosed by doctor 1.6 4.2 6.6 -1.0 -2.6 -2.3 -2.2 2.1 -2.5 1.1
Cholesterol lowering medication 2.7 4.0 9.0 -1.4 -1.9 -1.9 -1.7 3.0 -2.5 0.9
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.5 -0.6 -0.4 -0.3 -0.3 0.7 -0.4 0.7
Pain experienced in last month 1.0 1.6 3.8 0.1 -1.5 -1.4 -1.9 0.8 -0.6 1.5
Supplements: Calcium 0.6 0.6 2.7 1.6 -0.5 -0.8 -0.7 -0.4 0.3 0.2
Basal cell carcinoma (self-reported) 0.8 1.0 3.8 -1.9 -0.7 -0.7 -0.2 0.9 -1.0 -0.2
Heart attack/myocardial infarction (self-reported) 0.1 0.2 0.9 1.0 0.3 0.1 0.2 -0.2 0.3 -0.2
Deep venous thrombosis (DVT) (self-reported) 1.4 1.8 5.2 -0.6 -1.0 -0.9 -0.2 2.2 -2.3 -0.7
Heart disease (siblings) 1.3 1.5 2.6 -0.6 1.6 1.4 1.6 -0.9 1.5 -0.5
Alcohol drinker status: Previous 0.6 0.7 1.5 -0.2 0.9 0.9 1.2 -0.1 -0.5 -1.2
Pack years of smoking 1.0 1.5 9.1 3.0 -0.5 -0.8 -0.6 -0.0 -0.5 0.4
Impedance of whole body 0.4 2.0 4.4 -2.1 -1.2 -1.1 -1.8 1.1 -1.0 1.3
Leg fat mass (left) 0.3 1.0 6.2 2.5 0.1 0.0 0.5 0.5 0.3 -0.6
Arm predicted mass (left) 0.3 1.4 2.6 1.4 -1.0 -1.2 -0.4 1.6 -1.5 -0.7