Hub : Genes

SERHL2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0830 0.0310 9.6e-04 0.027 0.026 0.021 0.031 0.028 2.4e-04 3.5e-04 1.1e-03 9.4e-05 2.3e-04
2 GTEx Adipose Visceral Omentum 0.1650 0.0550 6.7e-04 0.056 NA 0.085 NA 0.066 7.3e-04 NA 3.7e-05 NA 2.5e-04
3 GTEx Artery Tibial 0.1348 0.0568 5.5e-03 0.017 NA 0.035 NA 0.010 1.6e-02 NA 9.2e-04 NA 4.8e-02
4 GTEx Brain Cerebellum 0.5150 0.0960 1.7e-05 0.044 NA 0.093 NA 0.069 1.9e-02 NA 1.1e-03 NA 4.4e-03
5 GTEx Brain Hypothalamus 0.6540 0.1190 2.0e-03 0.074 NA 0.160 NA 0.161 8.4e-03 NA 1.4e-04 NA 1.3e-04
6 GTEx Colon Transverse 0.1480 0.0590 4.1e-03 0.111 NA 0.063 NA 0.089 5.9e-06 NA 5.8e-04 NA 5.1e-05
7 GTEx Nerve Tibial 0.4401 0.0590 2.8e-16 0.240 NA 0.286 NA 0.283 5.4e-17 NA 1.8e-20 NA 3.0e-20
8 GTEx Prostate 0.2180 0.0880 8.5e-03 0.082 NA 0.025 NA 0.019 4.4e-03 NA 7.7e-02 NA 1.0e-01
9 GTEx Skin Sun Exposed Lower leg 0.1130 0.0400 3.2e-04 0.035 NA 0.061 NA 0.057 6.2e-04 NA 8.6e-06 NA 1.7e-05
10 GTEx Thyroid 0.0950 0.0390 3.9e-03 0.039 NA 0.054 NA 0.047 5.4e-04 NA 5.6e-05 NA 1.6e-04
11 NTR Blood 0.0185 0.0082 9.2e-03 0.011 0.005 0.014 0.010 0.013 1.1e-04 8.6e-03 1.6e-05 3.3e-04 3.0e-05
12 TCGA Breast Invasive Carcinoma 0.0872 0.0394 8.2e-09 0.034 0.043 0.042 NA 0.036 1.2e-07 3.7e-09 5.5e-09 NA 4.7e-08
13 TCGA Brain Lower Grade Glioma 0.1041 0.0472 2.9e-08 0.088 0.078 0.081 NA 0.086 3.7e-10 3.2e-09 1.6e-09 NA 5.9e-10
14 TCGA Lung Squamous Cell Carcinoma 0.1888 0.1123 4.2e-03 0.022 0.016 0.029 NA 0.011 1.2e-03 5.1e-03 2.5e-04 NA 1.8e-02
15 TCGA Prostate Adenocarcinoma 0.1368 0.0613 1.2e-04 0.010 0.042 0.056 NA 0.035 3.1e-02 3.2e-05 1.5e-06 NA 1.4e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bipolar Disorder (2018) 2.0 3.1 6.1 1.6 -1.9 1.0 -2.0 -0.7 -1.8 -1.6 -1.9 0.5 -2.1 -2.1 -2.2 2.5 -0.7 -2.4
Bipolar Disorder or Schizophrenia 0.9 2.1 9.6 1.0 -1.8 3.1 -1.7 -0.9 -0.8 -0.8 -0.8 1.4 -1.1 -1.1 -0.9 1.9 -0.7 -1.7
Depressed Affect (Nagel 2018) 0.3 0.7 2.1 -1.4 1.4 -0.5 1.0 -1.4 0.7 0.8 0.1 0.1 0.1 0.6 -0.7 -1.0 -0.0 0.1
Depression (Nagel 2018) 1.5 2.3 9.6 -3.1 1.2 0.4 1.4 -2.7 1.1 1.2 0.2 -1.3 -0.2 0.3 -0.8 -3.0 -0.1 0.1
Intelligence (Savage-Jansen 2018) 1.1 3.3 12.2 2.6 1.1 1.2 0.5 3.0 -0.2 0.8 2.4 2.7 1.3 0.7 0.5 3.5 -1.3 -1.3
Neuroticism (Nagel 2018) 0.3 0.8 2.1 -0.3 1.4 -0.4 0.4 -1.4 0.9 0.6 1.5 0.5 0.0 0.9 -1.4 -0.1 -1.2 -0.2
Schizophrenia (2018) 0.5 1.0 11.0 -0.1 -0.7 3.3 -0.6 -0.5 0.5 0.2 0.4 1.3 0.3 0.3 0.5 0.4 -0.3 -0.4
Schizophrenia vs Biploar Disorder 0.4 0.6 1.5 -0.4 1.0 -0.3 0.3 -0.1 1.2 0.8 0.6 -0.4 0.6 1.1 1.1 -0.9 0.5 0.8
Worry (Nagel 2018) 0.5 1.0 3.8 1.2 0.3 0.4 -1.0 -1.2 -0.1 -0.1 0.7 -0.2 -1.1 -0.3 -2.0 1.1 -1.4 -1.1
Alzheimer’s Disease (in mother) 0.8 0.9 4.0 -2.0 0.2 -0.2 1.5 -0.4 1.3 0.9 0.5 -1.0 0.9 0.7 0.5 -1.1 -0.1 -0.4
Alzheimer’s Disease (in father) 0.3 0.3 3.0 0.3 -0.2 1.7 0.2 0.3 -0.0 -0.1 -0.6 -0.4 -0.3 0.2 0.4 0.3 0.5 0.2
Alzheimer’s Disease (including proxy) 0.7 1.0 3.9 -1.7 0.6 1.1 2.0 0.4 1.2 1.2 0.2 -0.6 0.9 1.2 0.8 -0.8 0.4 -0.1
Crohns Disease (2017) 0.8 1.7 5.0 0.8 -2.2 -1.0 -0.7 -0.5 -0.9 -0.5 -2.2 -1.7 -1.4 -1.2 -1.6 0.8 -0.6 -1.6
Irritable Bowel Disease (IBD) 0.9 2.1 7.5 0.4 -2.0 0.5 0.1 -0.5 -0.8 -0.3 -2.7 -1.4 -1.5 -1.2 -1.9 1.4 -1.1 -2.4
Ulcerative Colitis (UC) 0.6 1.1 4.6 0.1 -0.7 1.3 0.9 0.3 -0.4 0.1 -2.1 -0.4 -0.7 -0.6 -1.0 1.3 -1.2 -1.7
Major Depression (MDD) 0.5 0.5 2.0 0.6 -0.9 0.8 -0.9 0.0 0.9 0.2 -1.4 0.7 0.1 0.5 -0.8 0.4 -1.0 -0.5
Reaction Time 0.3 0.7 2.0 0.6 -0.8 -1.4 -1.0 -0.3 -0.7 -1.4 -0.6 0.2 -0.6 -0.7 -1.1 -0.3 -1.0 0.0
Verbal and Numeric Reasoning (VNR) 0.7 1.6 10.6 1.7 0.5 -0.4 0.1 1.5 -0.7 -0.2 1.2 3.3 0.9 0.4 1.0 0.9 -0.6 1.6
Breast Cancer 0.5 1.2 8.4 1.1 -0.2 0.1 -0.4 1.1 -0.7 -0.8 -2.9 -1.7 -0.7 -0.9 -1.1 0.7 -0.3 -0.4
Ovarian Cancer 0.7 1.0 4.0 -1.7 0.7 -0.5 0.7 -0.7 1.0 0.3 0.9 -0.7 0.9 1.0 0.4 -2.0 0.2 1.4
Prostate Cancer 0.8 1.2 3.0 1.0 -0.4 -0.4 -1.6 -0.2 -1.7 -1.7 -1.6 0.7 -1.2 -1.2 -1.0 0.3 0.8 0.5
Age at First Birth 0.5 0.7 2.1 -0.1 -0.1 0.3 1.1 0.7 0.4 0.7 -0.3 0.5 1.3 1.1 -0.1 1.2 -1.5 -1.2
Bipolar Disorder (2011) 2.6 2.5 8.0 0.1 -1.4 1.6 -2.8 -1.7 -1.4 -1.4 -2.3 0.0 -2.5 -2.6 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.9 1.2 4.8 -1.2 0.8 1.1 1.3 -0.6 1.5 2.2 0.9 -1.5 -0.1 0.8 0.3 -1.4 0.3 0.0
Coronary Artery Disease (CAD) 0.6 0.7 5.0 1.4 -1.0 0.4 -0.4 0.2 -0.2 -0.3 -0.5 0.6 0.4 0.5 -0.2 2.2 -0.3 -1.0
Crohns Disease (2012) 1.3 2.1 6.8 1.3 -2.6 -0.4 -1.5 -1.0 -1.5 -0.8 -2.4 -0.3 -1.7 -1.5 -1.5 1.2 -0.2 -1.5
Mean Putamen Volume 0.8 0.9 3.3 -0.3 -1.6 -0.1 0.0 -1.0 -0.4 -0.2 -0.4 -1.8 -1.3 -0.8 0.2 -1.5 1.0 0.4
Fasting Glucose 0.6 0.7 3.2 -0.4 1.0 -0.1 1.1 -1.0 0.9 0.2 1.3 -1.8 0.0 0.4 0.0 -1.1 0.1 0.2
HbA1C 1.9 2.1 5.6 1.8 -0.7 0.5 -2.0 0.2 -1.6 -1.7 -2.4 0.1 -0.8 -1.5 -1.7 2.1 -0.9 -1.2
HDL Cholesterol 1.2 1.9 4.5 -0.0 0.9 0.2 1.9 2.0 1.3 1.3 1.0 1.6 2.1 2.1 2.0 0.3 -0.0 0.9
LDL Cholesterol 0.4 0.7 2.4 1.0 -1.4 -0.4 -0.5 -0.2 -0.6 -1.3 -0.9 0.0 0.2 0.2 0.0 -0.0 1.0 1.6
Lupus 1.0 1.5 5.4 -2.3 1.8 0.5 2.0 0.2 0.9 1.3 -1.1 -0.0 -0.0 0.6 1.1 -2.0 0.1 0.1
Neuroticism (2016) 0.7 0.9 4.4 0.2 -0.2 -1.2 0.6 -0.1 0.9 0.3 -0.1 2.1 0.9 1.6 -0.3 1.1 -1.4 -0.4
Primary Biliary Cirrhosis 1.7 2.4 11.2 -2.6 2.0 0.4 0.5 -2.5 0.6 1.0 0.4 -0.4 -1.7 -0.7 0.3 -3.4 1.2 1.0
Rheumatoid Arthritis 0.8 1.1 3.6 1.0 -0.5 0.3 -1.9 -0.6 -1.0 -1.3 -0.8 0.3 -0.9 -0.8 -1.5 1.5 0.4 -1.1
Schizophrenia (2014) 0.6 1.4 8.4 -0.3 -1.8 2.9 -1.5 -1.6 -0.2 -0.9 0.0 0.8 -0.5 -0.5 -0.5 0.7 -0.8 -1.2
Triglycerides 0.2 0.4 1.5 -0.5 0.5 -0.1 -0.2 -0.8 -0.5 0.1 0.6 -1.2 -0.7 -0.6 -0.9 -0.7 -0.4 0.3
Type 2 Diabetes (T2D) (2012) 0.3 0.3 1.2 -1.1 -0.1 0.2 0.1 -0.3 0.0 -0.5 -1.1 -0.4 -0.3 -0.4 0.0 -0.9 0.6 -0.3
Ulcerative Colitis 0.3 0.5 2.3 0.2 -1.3 0.8 0.2 0.2 -0.5 -0.3 -1.5 1.3 0.0 -0.2 -0.1 0.5 -0.4 0.2
Blood Eosinophil Count 1.3 9.9 21.9 -3.0 3.4 2.7 4.3 1.5 3.6 4.7 3.4 1.7 3.7 3.4 4.3 -1.8 1.3 1.3
Blood Platelet Count 1.0 12.1 47.2 -0.9 5.1 -2.8 4.4 1.5 1.4 4.0 6.1 -6.9 3.0 2.1 2.9 0.6 0.2 0.1
Blood Red Count 1.6 15.7 47.2 -4.2 3.0 2.9 3.0 -0.9 3.6 1.7 6.3 6.9 4.4 4.5 5.0 -3.2 -0.3 3.7
Blood White Count 0.8 6.2 16.2 -3.7 2.7 3.3 3.3 -0.6 2.4 2.0 1.3 2.3 1.8 1.5 2.5 -4.0 1.1 2.1
Heel T-Score 0.3 2.2 5.7 -1.8 1.0 0.2 2.1 -0.1 1.9 1.4 2.0 1.8 0.5 1.0 2.0 -2.4 0.7 0.3
BMI 0.4 2.5 8.2 -2.2 0.8 -0.6 1.7 -1.7 -0.7 0.1 -1.3 -1.5 -1.6 -1.6 1.1 -2.7 2.9 0.1
Height 0.3 6.7 23.0 0.8 3.7 2.3 1.4 3.8 2.5 4.3 4.8 -1.4 2.1 2.0 -0.4 2.1 -1.6 -0.6
Waist Hip Ratio (WHR) 0.4 2.0 5.4 0.2 -2.1 2.3 -2.0 -0.9 -0.5 -1.6 -1.5 0.9 -0.9 -0.9 -1.8 1.3 -0.9 -1.5
Systolic Blood Pressure 0.5 2.7 8.3 1.2 -2.6 1.6 -2.9 -1.3 -0.9 -2.3 -2.0 -1.4 -1.1 -1.0 -1.5 1.4 -0.8 -1.2
Smoking Status 1.6 3.8 24.3 -4.9 0.9 0.3 0.8 -2.1 1.3 1.2 -0.2 -2.4 -0.8 -0.8 -0.4 -4.0 0.8 -0.7
Allergy or Eczema 0.7 1.8 3.8 -1.7 1.9 1.6 1.9 0.9 1.1 1.9 0.4 -0.1 1.4 0.6 0.9 0.3 -1.7 -1.3
Cardiovascular Disease 0.3 1.1 5.4 -0.6 -2.3 1.6 -0.8 -0.6 -0.3 -1.4 -1.6 -0.3 -0.4 -0.8 0.5 0.1 0.8 -0.9
Hypothyroidism (self reported) 0.1 0.3 1.6 0.0 -0.8 -0.7 0.2 -0.4 -0.2 -0.0 0.2 -1.1 0.3 0.4 -0.5 -0.2 1.3 0.5
Respiratory disease 1.5 3.3 7.2 -2.4 2.2 1.2 2.7 0.5 2.1 2.1 1.0 -0.1 2.0 1.9 2.6 -1.6 1.5 1.1
Type 2 Diabetes (T2D) (2018) 0.5 0.9 2.2 -0.4 -0.8 1.3 -1.5 -1.2 -0.5 -1.4 -0.7 -1.1 -0.7 -0.9 -0.5 -0.1 1.3 -0.1
Lung FEV1/FVC ratio 0.8 4.2 11.6 3.4 -2.5 1.6 -2.2 0.9 -1.9 -2.3 -1.5 0.9 -1.4 -2.0 -1.5 2.7 -2.5 -1.6
Lung FVC 1.5 7.7 16.6 -1.8 3.9 1.7 2.2 1.5 3.1 2.5 4.1 2.5 3.7 3.7 3.2 -1.6 -0.3 2.7
Neuroticism 0.3 0.8 2.9 0.8 -0.1 -0.8 -0.4 -1.1 0.3 -0.2 0.6 0.0 -0.1 0.6 -1.6 1.7 -0.4 -1.4
Chronotype (morning person) 1.2 2.7 5.0 2.2 -1.4 -1.8 -2.2 -1.5 -1.6 -2.1 -1.3 -0.8 -2.1 -1.5 -1.6 1.6 -0.7 -1.4
Hair Pigment 0.0 0.4 2.7 -0.6 -0.1 1.5 0.1 1.6 -0.0 -0.3 -0.5 0.1 0.2 -0.4 0.4 -0.0 -0.2 -0.6
Tanning 0.1 0.9 3.1 1.8 -1.1 -1.5 -1.2 -0.5 -1.1 -0.7 0.6 0.4 -0.8 -0.3 -0.8 1.1 -0.3 0.4
Hand grip strength (left) 0.3 0.7 2.8 1.1 0.5 0.5 -0.1 0.7 -0.4 0.4 0.7 -1.7 0.1 0.1 0.6 1.3 1.2 0.4
Number of treatments/medications taken 0.6 1.1 4.9 -2.2 0.6 -0.4 1.7 -0.8 1.2 1.2 -0.7 -0.9 0.5 0.8 -0.1 -1.3 0.6 -0.6
Average weekly spirits intake 0.8 1.0 3.2 -0.2 1.5 -0.4 1.8 1.4 0.7 1.2 0.2 0.8 1.0 0.9 1.0 -0.7 0.9 0.7
Sensitivity / hurt feelings 0.2 0.4 1.6 0.8 0.3 -0.5 0.5 -0.3 -0.1 -0.8 1.3 0.1 -0.2 0.3 -1.2 0.5 0.1 0.2
Frequency of depressed mood in last 2 weeks 0.5 0.7 2.4 -1.1 0.6 -0.8 1.1 -1.5 -0.2 0.4 -0.1 -1.5 -0.8 -0.4 -0.7 -0.9 0.7 -0.5
Hearing difficulty/problems: Yes 1.2 1.8 5.5 -0.3 0.5 1.5 0.9 2.3 1.8 1.1 1.5 0.5 1.8 1.4 2.3 0.1 0.5 0.5
Relative age of first facial hair 1.5 3.2 15.4 3.9 -2.3 -1.3 -0.9 1.9 -1.9 -0.9 -1.2 0.2 0.5 0.6 -0.1 2.9 1.2 2.1
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 0.8 0.1 -0.5 -0.1 0.1 0.3 0.2 -0.7 0.3 -0.2 0.8 0.4 -0.3 0.2 -0.9 -0.2
Ever used hormone-replacement therapy (HRT) 0.9 1.2 5.2 -0.9 -0.5 -0.7 0.5 -0.4 -0.4 0.3 -0.8 -2.3 -1.0 -1.2 -0.3 -1.7 1.9 0.5
Ever had hysterectomy (womb removed) 1.1 1.2 3.2 0.5 -1.3 -1.2 -0.7 -1.1 -0.5 -0.8 -1.3 -0.1 -1.0 -0.6 -1.7 0.8 -1.6 -1.8
Systolic blood pressure, automated reading 0.9 2.7 6.4 0.6 -2.1 -0.5 -2.1 -1.9 -1.4 -2.5 -2.5 -1.4 -1.6 -1.5 -1.3 1.4 0.3 -1.6
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 4.5 -1.7 0.1 -0.4 -1.2 -2.1 -0.1 -0.6 -0.5 -1.8 -1.2 -1.0 -0.7 -0.8 1.4 -0.7
Angina 0.7 1.0 4.2 -0.6 0.0 1.1 -0.2 0.3 0.3 0.6 0.5 -2.1 -0.7 -0.9 -0.7 0.3 -1.3 -2.0
Medication for hormone replacement therapy 0.5 0.6 3.2 0.7 -1.8 -0.3 0.3 0.6 -0.4 0.1 -0.0 -0.6 -0.2 -0.3 -0.6 1.0 -0.6 -1.4
Vitamin and mineral supplements 1.9 2.6 5.0 1.6 -2.0 0.2 -2.2 -1.1 -1.7 -2.1 -0.8 -0.1 -1.5 -1.8 -1.9 1.9 -1.5 -1.8
Supplements: Zinc 0.5 0.5 1.6 -0.4 -0.5 -0.6 -0.6 -0.3 -0.6 -0.6 0.1 -0.8 -0.9 -1.3 -1.2 -0.5 -0.5 -0.7
Medication: Co-codamol 1.5 1.7 4.4 -1.0 1.1 1.6 0.8 0.4 0.5 0.7 1.8 2.1 0.7 -0.0 1.7 -1.9 0.4 2.0
Medication: Metformin 0.4 0.5 1.9 -1.2 -0.3 0.4 -0.0 0.1 0.3 -0.2 -0.2 0.5 0.6 0.4 1.1 -1.4 1.0 1.3
Diabetes (father) 0.8 0.9 2.8 0.0 -1.7 -0.1 -0.6 -1.2 -0.5 -0.3 -0.9 -1.2 -1.5 -1.1 0.0 -1.4 1.0 0.7
Diabetes (mother) 0.4 0.5 1.8 0.5 -1.3 0.4 -1.1 -0.1 -0.8 -1.3 -0.4 1.2 0.1 -0.2 -0.1 0.4 0.4 0.7
Severe depression (siblings) 0.1 0.1 0.5 -0.5 0.5 -0.7 0.3 0.0 -0.2 0.2 -0.5 0.1 0.2 0.4 0.6 -0.2 -0.1 0.3
Pack years adult smoking proportion 1.0 1.6 6.2 -0.7 -0.4 0.6 -1.0 -2.5 -0.5 -0.6 0.3 -0.8 -2.4 -1.7 -1.7 -0.6 0.5 -1.6
Impedance of leg (right) 0.4 2.1 8.0 1.6 -1.5 1.0 -1.4 1.0 -0.8 -0.6 -0.6 -0.6 -0.8 -0.8 -2.0 2.8 -1.9 -2.2
Leg fat-free mass (left) 0.4 2.3 8.0 -1.6 2.8 -0.2 2.0 0.4 1.0 1.9 2.2 -0.6 0.7 0.6 1.7 -1.8 1.6 0.9
Trunk fat percentage 1.0 3.8 13.4 -3.7 3.3 1.0 3.6 0.7 1.8 2.5 -0.3 -0.3 0.2 0.3 1.9 -2.0 0.7 -1.1
Hand grip strength (right) 0.4 1.2 4.1 1.5 0.4 1.3 -0.0 1.0 -1.1 0.0 0.6 -2.0 -0.4 -0.5 0.8 1.9 1.6 0.2
Townsend deprivation index at recruitment 0.5 0.7 3.0 -1.7 0.9 0.4 1.0 -0.4 0.6 1.2 1.0 0.2 0.3 0.2 -0.3 -1.4 -0.1 -0.2
Current tobacco smoking 1.5 2.5 9.6 -3.1 -0.1 1.6 -0.5 -1.7 0.3 0.6 -1.7 -1.3 -1.6 -1.6 -1.2 -3.1 -0.2 -0.8
Average weekly fortified wine intake 1.4 1.6 6.9 2.5 0.7 0.3 1.3 2.6 -0.1 0.8 0.5 1.4 1.1 1.0 0.6 1.8 -0.4 0.5
Maternal smoking around birth 0.4 0.6 3.4 -1.8 0.2 -0.7 0.5 -0.9 0.1 0.2 -0.8 -1.1 0.2 -0.1 -0.3 -0.5 0.8 -0.9
Fed-up feelings 0.1 0.2 1.1 -0.2 1.1 0.1 0.9 0.1 -0.0 0.6 0.2 -0.1 -0.2 -0.2 -0.3 -0.1 0.8 -0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 3.0 3.9 13.9 -3.7 2.5 1.2 2.1 -2.1 2.3 2.2 1.9 -0.9 0.4 1.0 -0.1 -3.5 -0.0 0.3
Relative age voice broke 1.2 1.8 10.5 3.2 -1.1 -1.0 -0.6 0.5 -1.6 -0.9 -0.1 0.7 -0.0 0.1 -0.2 2.9 1.2 0.6
Taking other prescription medications 1.5 2.3 6.5 -2.0 1.3 1.1 2.5 0.9 1.8 2.3 -0.3 0.8 1.6 1.7 1.6 -1.3 1.0 0.7
Age when periods started (menarche) 0.7 1.7 10.8 2.1 -0.3 0.3 0.2 2.0 0.1 0.5 -0.2 -0.6 1.8 1.4 -0.0 3.3 -0.6 -0.7
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.8 -0.3 -1.1 -0.5 -0.0 -1.2 0.4 0.1 -0.0 -0.1 -0.2 0.4 -1.2 -0.5 -1.4 -0.0
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 4.2 -2.0 -0.3 -0.8 1.2 -0.4 1.6 1.6 -0.2 0.2 0.1 0.8 0.7 -1.3 0.5 -1.0
Tinnitus: Yes, but not now, but have in the past 1.0 1.0 1.8 -0.5 1.4 1.2 0.9 0.2 1.0 1.2 1.2 1.1 1.0 1.1 0.8 -1.0 -0.8 1.1
Qualifications: CSEs or equivalent 0.3 0.4 1.8 -0.6 0.1 -0.6 -0.5 -1.2 0.1 -0.5 -1.3 -0.2 -0.2 -0.1 -0.2 -0.2 1.1 -0.5
Serious illness, injury or assault to yourself 0.2 0.3 0.9 -1.0 -0.4 -0.0 -0.4 -0.4 0.4 -0.1 -0.7 0.8 -0.1 -0.1 0.3 -0.8 0.6 0.3
High blood pressure 0.8 2.2 8.5 0.2 -2.9 0.4 -1.9 -0.8 -1.3 -2.4 -2.2 0.4 -0.8 -1.6 0.4 0.9 1.5 -0.9
Hayfever, allergic rhinitis or eczema 0.7 1.6 3.9 -1.4 1.9 1.5 1.8 1.3 1.1 2.0 0.4 -0.2 1.5 0.5 0.8 -0.1 -1.2 -0.7
Multivitamins +/- minerals 0.8 1.0 2.5 -1.2 1.4 0.2 1.2 0.5 1.3 1.6 0.5 -0.1 0.8 1.0 1.1 -1.0 1.2 0.6
Stomach or abdominal pain in last month 0.9 1.1 6.4 -0.4 0.7 0.7 2.5 0.8 0.1 1.6 0.0 0.4 0.4 0.3 1.5 -1.3 0.3 1.1
Supplements: Glucosamine 0.3 0.4 1.8 0.4 0.4 -0.3 -0.1 1.0 -0.3 -0.4 1.3 1.0 0.3 -0.1 -0.5 0.0 -0.4 0.7
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 4.4 -1.5 0.5 -1.0 1.3 -1.2 -0.4 0.4 -0.8 -1.6 -1.3 -1.2 -0.4 -2.1 1.3 -0.3
Medication: Atenolol 0.8 0.9 3.2 -0.0 0.2 1.3 1.8 1.4 0.7 1.1 -0.4 1.3 1.0 0.6 1.5 0.1 0.1 -0.1
Medication: Levothyroxine sodium 0.2 0.4 1.2 -0.2 -0.7 -0.7 0.3 -0.4 -0.1 -0.4 -0.1 0.7 0.8 0.8 0.2 -0.2 1.1 1.0
Sitting height 0.5 3.2 11.3 2.1 2.4 -0.1 1.2 2.9 0.5 2.3 3.4 -1.0 0.7 0.7 -0.2 2.8 -0.5 -1.4
Chronic bronchitis/emphysema (father) 0.9 1.1 4.8 -1.5 0.3 1.4 1.0 0.2 1.3 1.2 -2.2 -0.9 0.3 0.8 0.3 -0.5 0.9 -0.6
High blood pressure (mother) 0.4 0.5 1.5 0.4 -0.7 1.1 -1.0 -0.4 -0.6 -1.2 -0.5 0.5 -0.7 -1.0 0.5 -0.1 0.3 0.7
Body mass index (BMI) 0.4 1.9 7.0 -2.4 1.7 -0.3 1.9 -1.4 0.1 0.5 -0.8 -0.5 -1.0 -0.7 1.1 -2.7 1.9 0.2
Impedance of leg (left) 0.5 2.2 10.0 1.9 -1.1 1.3 -1.1 1.5 -0.3 -0.2 -0.4 -0.5 -0.5 -0.3 -1.8 3.2 -2.1 -2.1
Leg predicted mass (left) 0.5 2.4 8.1 -1.6 2.8 -0.3 2.1 0.4 1.0 1.9 2.1 -0.5 0.7 0.6 1.8 -1.8 1.6 1.0
Trunk fat mass 0.8 3.5 11.7 -3.3 3.3 0.7 3.4 0.5 1.6 2.4 0.0 -0.6 0.2 0.3 1.9 -2.0 1.2 -0.8
Waist circumference 0.3 1.2 4.9 -2.2 1.4 0.5 1.9 -0.4 0.6 0.6 -0.5 0.5 -0.0 0.1 1.1 -1.6 1.4 -0.1
Number of incorrect matches in round 2.0 3.3 8.0 1.8 -2.6 -0.9 -2.6 -0.2 -1.1 -2.4 -2.8 -0.0 -0.9 -1.0 -1.6 2.6 -0.9 -2.0
Past tobacco smoking 1.1 2.0 5.5 1.9 -1.6 -0.4 -2.3 -1.1 -1.5 -1.7 -1.2 0.2 -1.2 -1.5 -1.2 1.5 -1.2 -0.8
Alcohol usually taken with meals 1.1 1.7 7.4 2.1 -0.7 -1.5 -1.2 -0.7 -0.9 -0.3 0.7 -1.6 -0.9 -0.5 -0.8 2.7 0.4 -1.8
Nervous feelings 0.4 0.7 3.5 0.4 0.3 1.9 -0.3 -0.5 0.3 0.1 0.6 0.3 -0.9 -0.3 -1.2 1.1 -0.9 -1.3
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 3.1 -0.6 0.4 0.0 1.8 -0.3 0.4 1.0 -0.2 0.1 0.3 0.8 0.3 0.0 -0.1 -0.7
Hearing difficulty/problems with background noise 0.6 1.0 3.5 1.2 -0.2 1.8 -0.5 1.9 0.5 0.3 1.0 -0.4 0.9 0.6 0.4 1.7 -0.6 -0.4
Hair/balding pattern: Pattern 2 0.7 0.9 4.1 -0.9 -0.4 -0.1 -0.6 -2.0 -0.6 -0.9 0.3 -0.9 -0.9 -1.0 -0.3 0.6 1.2 -1.5
Had menopause 0.2 0.3 1.1 -0.6 -0.6 -0.1 -0.2 0.2 -0.4 -0.4 -0.9 1.1 -0.2 -0.7 0.6 -0.2 0.5 -0.3
Had other major operations 3.4 4.2 11.1 -2.2 1.4 1.8 3.3 2.8 2.1 2.4 0.4 1.7 2.1 1.6 2.0 -2.7 -0.0 1.5
Forced vital capacity (FVC) 1.3 5.0 16.4 -0.7 3.3 2.1 1.0 2.7 2.6 2.5 4.1 1.0 3.0 2.4 2.0 -0.0 -0.6 1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.9 4.5 -1.9 0.5 -1.2 2.1 0.2 1.8 2.1 0.9 0.4 1.1 1.6 1.9 -1.4 1.0 -0.1
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 1.2 -0.3 0.2 0.7 0.0 1.0 -0.1 0.2 -0.3 0.5 0.4 0.1 0.3 -0.6 0.7 1.1
Qualifications: None of the above 1.1 2.4 8.5 -2.8 0.3 -0.1 0.2 -2.9 0.4 -0.5 -2.1 -1.6 -1.4 -0.7 -1.0 -2.4 1.7 -0.5
Financial difficulties in last 2 years 1.4 1.9 8.9 -1.9 1.1 1.1 2.1 -0.3 0.8 1.3 0.9 0.7 0.0 0.3 0.9 -3.0 1.0 1.6
Mouth/teeth dental problems 2.1 3.2 11.8 0.2 2.6 1.1 1.8 3.4 1.7 1.9 0.7 1.5 2.0 1.6 2.3 0.4 -1.7 0.6
Heart attack 0.5 0.7 1.9 -0.2 -0.5 1.3 -0.3 -0.0 -0.1 0.4 -0.3 -1.0 -1.1 -1.0 -1.4 -0.1 -1.3 -1.2
Allergy 1.7 3.9 11.1 2.8 -2.3 -2.5 -2.8 -0.8 -2.7 -3.3 -0.8 0.7 -2.1 -1.7 -1.6 1.0 0.1 0.6
Pain all over the body in last month 0.3 0.4 1.5 -1.0 0.3 0.2 -0.4 -0.9 0.1 0.2 0.3 -1.0 -0.6 -0.3 -0.6 -1.2 0.2 0.1
Diabetes (self-reported) 0.5 0.7 5.5 -0.6 0.3 2.3 -0.3 0.6 0.2 -0.3 -0.2 0.5 0.9 0.1 0.8 -0.4 1.1 1.1
Hayfever/allergic rhinitis (self-reported) 1.1 1.5 4.4 -2.1 1.5 1.1 0.8 0.9 1.7 1.5 -0.1 -0.7 1.5 0.9 0.8 -0.3 -1.5 -1.2
Medication: Ramipril 0.3 0.4 1.8 -0.4 -0.2 -0.7 -0.7 -1.3 0.1 -0.8 -0.0 -0.6 -0.6 -0.1 -1.2 -0.3 0.6 -0.2
Medication: Simvastatin 0.2 0.3 1.1 -0.5 -0.5 0.1 0.9 -0.5 0.2 0.1 -1.1 -0.7 -0.3 0.2 -0.2 0.1 -0.2 -1.0
Fluid intelligence score 0.4 0.9 2.8 1.0 0.5 0.7 0.0 1.6 -0.3 0.4 1.0 1.7 0.9 0.5 0.9 0.3 -0.2 1.6
Illnesses of siblings 0.6 0.9 3.0 1.1 0.6 0.4 -1.3 0.7 -0.4 0.3 0.2 1.7 -0.6 -0.8 -0.9 1.4 -1.0 -0.8
Neuroticism score 0.2 0.5 2.3 0.5 0.4 0.0 -0.0 -1.0 0.2 0.1 1.0 -0.2 -0.5 0.1 -1.5 1.0 -0.2 -1.1
Weight 0.4 1.8 7.5 -1.6 2.7 -0.1 2.4 0.4 0.7 1.7 0.9 -0.5 0.0 0.1 1.4 -1.3 1.5 -0.0
Impedance of arm (right) 0.3 1.3 5.2 -1.2 0.1 0.2 0.3 1.4 1.6 1.1 -0.1 0.9 1.4 1.3 0.2 0.6 -2.3 -1.2
Arm fat percentage (right) 0.6 2.3 11.4 -3.4 1.8 -0.2 2.1 -1.0 0.7 0.9 -1.2 -0.3 -0.7 -0.6 1.3 -2.7 1.1 -0.6
Trunk fat-free mass 0.1 0.8 4.8 0.9 1.0 -0.5 0.1 -0.4 -0.5 0.4 2.2 -0.9 -0.3 -0.3 0.3 0.1 1.6 0.7
Hip circumference 0.4 1.9 6.7 -1.8 2.1 -0.7 2.6 0.1 0.5 1.3 0.3 -0.0 0.2 0.3 1.9 -2.0 1.9 0.9
Time employed in main current job 0.8 0.9 3.8 0.6 -0.1 1.5 0.3 0.9 -0.0 0.3 0.1 0.5 0.5 0.2 -1.0 1.8 -1.9 -1.4
Alcohol intake versus 10 years previously 0.9 1.3 4.0 -1.3 0.5 -0.3 -0.0 -1.2 -1.0 -0.7 -1.8 -2.0 -1.3 -1.4 -1.2 -0.8 -0.2 -1.3
Father’s age at death 1.1 1.5 6.3 0.8 -0.3 1.2 1.4 2.5 0.3 0.9 0.7 0.6 2.4 1.2 1.0 1.1 -0.8 0.3
Worrier / anxious feelings 0.4 0.7 4.7 1.4 0.5 0.4 -0.0 0.5 -0.3 0.0 1.5 0.4 0.1 0.2 -0.7 2.2 -0.0 -0.6
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.2 5.9 -2.4 0.9 0.1 0.8 -1.8 0.8 1.1 0.6 -1.2 -0.1 -0.0 -0.6 -1.7 0.5 -0.3
Falls in the last year 0.6 0.8 2.8 -0.9 1.1 1.7 0.9 0.8 0.1 1.0 1.2 0.8 0.2 0.2 0.9 -0.9 0.2 1.0
Hair/balding pattern: Pattern 3 0.3 0.4 4.6 -0.4 -0.0 -2.1 0.3 -0.4 0.0 -0.6 0.0 -0.2 0.4 0.3 -0.9 -0.4 -0.2 0.0
Number of live births 0.6 0.9 3.3 1.0 -1.8 1.1 -1.5 0.4 -0.8 -0.8 -0.4 -0.6 -0.4 -1.1 -0.1 0.8 1.2 -0.0
Forced expiratory volume in 1-second (FEV1) 1.2 4.0 10.4 -0.0 2.3 2.6 0.6 2.8 2.3 1.9 3.2 1.6 2.7 1.9 1.6 0.6 -1.8 0.7
Pulse rate 0.7 1.3 4.4 1.2 -0.1 0.6 -0.7 0.5 -2.0 -1.3 0.3 -0.7 -1.6 -2.1 -0.9 1.2 0.7 -0.8
Happiness 0.1 0.2 0.6 -0.6 -0.1 0.2 0.8 0.0 -0.6 0.2 -0.0 -0.5 0.5 -0.3 0.2 0.3 0.7 -0.1
Noisy workplace 2.2 2.7 7.1 0.0 -1.2 -1.8 -1.9 -1.9 -0.7 -1.6 -1.2 -1.5 -1.7 -1.3 -2.7 1.2 -1.4 -2.6
Qualifications: A levels/AS levels or equivalent 1.6 3.5 15.5 3.9 -0.1 0.0 -0.1 2.8 -0.8 -0.6 2.7 2.2 1.2 0.8 0.8 3.3 -1.1 1.2
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.2 3.0 -1.7 1.7 0.4 1.0 -0.1 1.2 1.0 1.5 0.1 1.6 0.9 1.6 -0.6 -0.0 0.4
Mouth/teeth dental problems: Dentures 1.0 1.6 9.4 -1.9 -1.0 0.7 0.3 -3.1 -0.3 -0.3 0.7 -1.1 -0.9 -0.4 -1.3 -1.1 1.9 -0.2
Asthma 2.1 4.2 10.3 -2.0 1.8 2.0 3.2 0.8 2.3 2.6 1.6 -0.2 2.1 2.2 2.8 -1.5 1.9 1.5
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.5 4.7 -0.4 2.2 0.1 0.7 -0.6 -0.3 1.4 1.3 -1.9 -1.0 -0.9 -1.7 0.6 -0.9 -1.7
Medication: Cholesterol lowering 0.4 0.6 2.5 -0.9 1.6 0.3 0.6 -0.7 1.0 0.7 0.6 -0.5 0.6 0.9 0.6 -0.7 0.8 0.4
Depression (self-reported) 0.6 0.8 3.8 -0.6 0.6 1.0 0.5 -0.4 -0.0 0.5 -1.9 -1.7 -0.5 -0.2 -0.0 -0.6 1.1 -0.6
Medication: Lansoprazole 1.4 1.6 5.0 -1.0 0.4 -0.4 -0.5 -1.7 -0.1 -0.2 0.2 -2.0 -2.0 -1.3 -2.0 -0.0 -0.1 -2.2
Prospective memory result 3.8 4.7 12.3 1.9 -2.4 -2.3 -2.7 -1.4 -2.7 -3.5 -2.2 -1.0 -2.5 -2.5 -1.9 1.7 0.7 -1.2
Lung cancer (father) 1.9 2.2 8.2 -1.0 -1.3 -2.2 -0.9 -2.9 -0.7 -1.3 -0.2 -2.2 -1.7 -1.0 -1.5 -0.5 1.2 -1.4
Illnesses of mother 0.9 1.1 2.3 -1.5 1.5 -0.3 0.7 -1.5 1.1 1.2 1.1 -0.1 -0.5 0.4 -0.4 -1.1 -1.2 -1.2
Forced expiratory volume in 1-second (FEV1), Best measure 1.6 5.1 13.5 0.2 2.7 2.9 1.2 3.3 2.4 2.2 3.7 1.4 2.9 2.2 1.8 0.6 -1.7 1.0
Pulse wave Arterial Stiffness index 0.8 0.9 2.9 -0.1 1.2 0.5 0.7 1.1 1.4 1.1 -0.2 0.6 1.7 1.7 0.8 0.7 0.3 0.4
Impedance of arm (left) 0.4 1.8 5.4 -1.6 0.8 0.5 0.9 1.8 2.0 1.8 -0.1 0.4 1.5 1.6 0.3 0.5 -2.3 -1.3
Arm fat mass (right) 0.4 1.5 5.6 -2.4 1.8 -0.1 1.9 -0.8 0.3 0.8 -0.6 -0.7 -0.9 -0.8 0.9 -2.0 1.4 -0.6
Trunk predicted mass 0.1 0.8 4.8 0.9 1.0 -0.5 0.1 -0.3 -0.5 0.4 2.2 -0.9 -0.2 -0.2 0.4 0.1 1.6 0.8
Standing height 0.4 4.1 14.5 1.7 2.4 0.9 1.0 3.7 1.2 2.6 3.8 -0.3 1.8 1.5 0.4 2.8 -0.8 -0.6
Length of working week for main job 0.6 0.7 1.8 -0.9 0.9 0.4 0.7 0.4 0.9 1.0 0.9 0.6 1.4 1.1 1.3 -0.3 -0.2 0.2
Exposure to tobacco smoke at home 0.2 0.3 1.2 -0.1 -0.1 0.5 0.4 0.1 0.2 -0.5 1.1 -0.8 -0.4 -0.4 -0.0 -0.9 0.4 0.1
Breastfed as a baby 0.3 0.3 1.7 -0.5 0.2 -0.6 -0.1 -0.9 -0.1 0.0 1.3 -0.4 -0.0 -0.3 -0.2 -0.8 0.8 -0.0
Tense / ‘highly strung’ 0.7 1.1 3.4 1.4 0.1 -1.6 -0.9 -0.9 -0.8 -0.8 -0.1 -1.8 -1.6 -0.7 -1.1 1.0 0.4 -0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 4.6 -0.1 -0.2 0.4 0.6 -0.1 -0.2 0.3 -2.1 -0.8 -0.6 -0.4 -0.5 -0.5 1.5 -0.4
Hair/balding pattern: Pattern 4 0.2 0.4 1.9 1.0 -0.6 -0.6 -0.3 0.7 -0.3 0.0 -0.3 1.2 0.4 0.2 0.0 -0.2 0.2 1.4
Birth weight of first child 0.7 1.2 5.3 2.3 -0.8 -0.9 -0.8 0.8 -1.2 -1.0 -0.6 0.1 -0.1 -0.5 -0.9 2.0 -1.4 -0.1
Peak expiratory flow (PEF) 1.5 3.4 8.7 -0.2 2.0 3.0 0.6 2.3 2.4 2.1 1.9 1.4 2.7 1.8 1.5 0.2 -2.0 0.4
Pulse wave reflection index 0.4 0.5 1.4 0.3 -0.8 -1.0 -1.0 -0.6 0.9 -0.2 -1.2 -0.2 0.7 1.1 0.1 0.6 0.4 0.2
Ever highly irritable/argumentative for 2 days 0.7 0.8 3.1 -1.8 1.5 0.8 1.3 0.3 0.8 1.2 0.7 -0.3 -0.4 -0.2 0.0 -1.4 0.3 -0.0
Loud music exposure frequency 1.7 1.9 9.7 -1.5 0.5 -0.5 -0.9 -1.3 0.3 0.1 0.3 -3.1 -1.6 -1.4 -1.2 -2.5 0.6 -0.1
Qualifications: O levels/GCSEs or equivalent 0.5 0.9 3.1 0.5 0.7 0.6 0.6 1.8 -0.0 0.7 1.8 1.2 0.7 0.3 1.1 0.7 -0.7 0.6
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 1.1 1.0 -0.3 -0.4 -0.8 -0.2 -0.1 -0.3 -0.3 -0.6 -0.4 0.0 -0.6 1.0 -0.6 -0.3
Blood clot in the leg (DVT) 0.9 1.1 3.2 0.0 0.8 1.3 -0.1 0.7 1.6 0.7 -1.4 -0.3 1.8 1.8 1.0 1.3 -0.6 -0.2
Medication: Paracetamol 0.4 0.6 1.9 -0.9 0.5 0.2 0.3 -1.4 0.4 0.7 0.5 -1.3 -0.9 -0.2 -0.8 -0.3 0.8 -1.2
Headache pain in last month 1.2 2.0 9.0 -1.9 -0.6 -0.7 -0.6 -3.0 -0.4 -0.5 -0.7 -1.7 -1.5 -1.3 -2.3 -0.9 0.5 -1.4
Medication for cholesterol, blood pressure or diabetes 0.3 0.6 2.9 0.7 -0.4 0.5 -0.1 1.3 -0.4 0.2 -0.1 0.9 -0.0 -0.4 -0.8 0.9 -1.7 -0.6
Glaucoma (self-reported) 0.3 0.3 1.0 -0.8 0.1 -0.5 0.8 -0.7 0.3 0.3 -1.0 0.9 0.2 0.5 -0.2 -0.3 -0.1 -0.2
Gout (self-reported) 1.7 2.3 5.4 1.1 -1.4 -1.4 -2.1 -0.6 -2.0 -2.1 0.3 -1.2 -1.8 -2.3 -1.5 1.1 -1.0 -1.3
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 1.1 -0.3 -0.9 -1.0 0.1 -0.5 -0.4 -0.2 -0.3 -0.1 0.2 0.2 -0.3 -0.2 1.0 0.5
Medication: Amlodipine 0.7 1.0 4.6 -0.1 -2.2 -1.3 -1.7 -1.2 -0.4 -1.7 0.1 0.7 -0.0 -0.2 -0.7 -0.2 -0.3 0.3
Medication: Ventolin 100micrograms inhaler 2.7 3.5 7.6 -1.7 2.6 2.0 2.0 0.6 2.5 2.7 1.7 0.5 1.9 2.0 2.4 -1.3 1.1 1.0
Birth weight 0.1 0.3 1.5 0.5 0.5 0.9 -0.0 1.2 0.1 0.5 0.7 0.5 0.4 -0.0 0.3 0.4 -0.4 0.5
Chronic bronchitis/emphysema (mother) 0.9 1.1 4.2 -0.0 -1.2 -1.5 -0.6 -0.3 -1.3 -1.0 -2.1 -0.3 -0.7 -0.8 -0.6 0.9 1.2 -0.9
High blood pressure (siblings) 1.0 1.4 5.5 -1.7 -0.9 -0.8 1.5 -0.7 0.6 0.0 -1.2 -2.1 0.4 0.6 0.7 -2.3 0.2 1.1
Forced vital capacity (FVC), Best measure 1.6 5.8 19.1 -0.2 3.1 2.4 1.2 3.4 2.5 2.4 4.4 1.2 3.2 2.5 2.2 0.1 -0.7 1.9
Body fat percentage 0.8 3.1 11.5 -3.4 2.9 0.8 3.2 0.3 1.3 2.0 -0.9 -0.5 -0.1 0.0 1.6 -2.2 0.9 -0.8
Leg fat percentage (right) 0.4 1.5 5.2 -2.1 1.7 -0.0 2.3 -0.5 0.1 0.6 -1.6 -0.7 -0.7 -0.6 0.9 -1.4 1.4 -0.8
Arm fat-free mass (right) 0.2 0.8 3.1 0.5 1.7 0.4 0.7 0.4 -0.2 0.9 1.5 -1.1 -0.4 -0.4 0.6 -0.1 1.8 0.5
Exposure to tobacco smoke outside home 0.7 1.0 8.9 -1.4 0.7 0.0 0.3 -0.1 0.3 0.1 -0.1 -0.7 -0.6 -0.5 0.4 -3.0 0.3 1.4
Comparative body size at age 10 0.3 0.9 2.1 0.8 0.3 -1.2 -0.3 -1.2 -0.8 -0.9 0.3 1.3 -1.3 -0.6 0.2 -1.5 -0.5 1.2
Number of full brothers 0.9 1.1 4.9 -1.7 0.3 0.0 0.4 -0.5 1.4 1.1 -0.3 -0.9 0.5 0.5 -1.3 -0.1 -1.3 -2.2
Worry too long after embarrassment 0.9 1.6 9.1 0.1 -0.1 -0.0 -0.5 0.3 1.6 0.0 1.9 1.1 1.6 1.3 -1.3 0.5 -3.0 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 3.7 -0.1 -0.6 1.0 -0.1 -0.1 -0.1 0.2 -1.9 0.0 -0.0 0.1 -0.1 0.4 0.6 -0.7
Wheeze or whistling in the chest in last year 1.2 2.1 9.7 -3.1 1.1 1.4 1.1 -0.8 1.6 1.2 0.1 -1.6 0.4 0.7 0.6 -2.4 1.8 0.6
Number of children fathered 0.9 1.0 4.2 1.4 -1.6 0.4 -0.0 0.4 -1.0 -0.9 -0.8 -0.3 -0.2 -0.7 -0.4 2.1 0.3 -1.6
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 1.1 0.1 -0.3 -0.2 -0.1 -0.4 -0.2 -0.3 1.0 -0.0 -0.2 -0.4 -0.7 0.6 -0.4 -1.0
Age at first live birth 0.8 1.5 4.3 1.8 0.8 -0.8 0.7 1.7 -0.3 0.6 1.2 0.2 2.1 1.4 1.1 1.8 -0.4 1.3
Pulse wave peak to peak time 0.6 0.7 2.5 0.1 -0.8 -0.2 -0.4 -0.7 -1.2 -0.7 0.5 -0.7 -1.4 -1.6 -0.9 -0.7 -0.4 -0.6
Health satisfaction 0.9 1.2 6.0 -1.2 0.4 1.1 2.5 0.8 0.6 0.8 1.3 0.7 1.7 0.9 0.7 -0.5 0.3 0.5
Shortness of breath walking on level ground 0.6 0.7 2.3 -1.2 0.5 -0.6 0.6 -0.8 -0.8 -0.8 -0.1 -0.9 -0.9 -1.3 -0.5 -1.5 0.9 -0.1
Qualifications: College or University degree 1.0 3.1 17.2 3.2 0.1 -1.0 -0.5 2.1 -0.6 -0.5 2.4 0.7 0.8 1.1 0.0 4.1 -1.8 -1.1
Eye problems/disorders: None of the above 1.1 1.2 5.6 0.4 0.9 1.6 1.0 1.0 0.4 1.1 2.4 0.2 0.0 0.0 0.1 1.3 -1.3 -1.6
Mouth/teeth dental problems: Loose teeth 1.0 1.2 3.6 1.3 -1.5 0.7 -1.2 -1.1 -1.3 -1.9 0.9 1.4 -0.9 -0.7 -0.9 1.0 -0.5 0.3
Emphysema/chronic bronchitis 0.8 0.9 2.9 -1.7 -0.5 1.0 -0.2 -1.6 0.3 0.3 -1.5 -0.3 -0.7 -0.7 -0.4 -1.2 0.6 -0.9
Medication for pain relief, constipation, heartburn 1.3 2.1 5.0 2.2 -1.8 0.7 -1.4 2.0 -0.9 -1.5 -0.5 2.2 1.4 0.3 1.4 1.2 -0.1 2.0
Neck or shoulder pain in last month 0.6 0.9 4.4 -0.8 1.3 1.5 2.1 0.9 0.5 1.5 0.6 -0.0 0.2 0.5 -0.3 -0.7 0.0 0.6
Medication: Blood pressure 0.4 0.7 3.3 -0.9 -0.4 -0.6 -0.3 -1.4 -0.2 -1.0 0.0 0.0 -0.3 -0.4 0.9 -0.9 1.8 0.6
Angina (self-reported) 0.9 1.2 5.7 -0.4 0.0 1.1 -0.3 0.2 0.2 0.4 0.8 -2.4 -1.0 -1.1 -0.8 0.4 -1.3 -2.2
Migraine (self-reported) 3.8 4.8 10.8 -0.6 -3.2 -1.9 -1.2 -2.5 -2.2 -1.7 -1.5 -3.3 -2.8 -2.7 -2.2 -0.1 2.0 -2.1
Medication: Ibuprofen 1.0 1.2 4.3 -0.3 2.1 0.2 0.3 -0.5 -0.2 1.2 0.5 -1.9 -0.9 -0.8 -1.2 1.0 -0.2 -2.0
Medication: Allopurinol 1.8 2.4 6.3 0.4 -1.6 -1.6 -1.6 -1.5 -2.1 -2.0 -0.7 -0.7 -2.5 -2.4 -1.5 0.4 -0.2 -1.5
Medication: Omeprazole 0.9 1.1 3.8 -2.0 1.1 1.2 2.0 -0.2 1.0 1.3 0.2 0.2 -0.1 0.3 0.6 -1.1 -0.6 -1.1
Medication: Seretide 50 evohaler 0.2 0.2 1.0 -0.1 0.4 -0.1 0.2 -0.7 0.3 -0.2 0.4 0.4 -0.1 0.5 0.3 -0.6 1.0 0.7
Mean time to correctly identify matches 0.4 0.7 2.7 1.1 -1.0 -1.6 -0.7 -0.3 -0.9 -1.5 -0.7 0.4 -0.8 -0.5 -0.8 -0.1 -0.4 0.3
Heart disease (mother) 2.4 2.9 6.8 0.5 0.5 1.4 1.7 2.4 1.0 1.4 0.7 0.6 2.4 2.1 2.5 0.4 2.6 2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 5.2 -0.4 -0.5 -0.2 -0.4 -2.3 -1.2 -1.1 0.1 -0.2 -1.5 -1.2 -0.3 -0.9 1.0 0.3
Whole body fat mass 0.6 2.5 8.1 -2.8 2.7 0.4 2.9 0.2 1.0 1.8 -0.0 -0.7 -0.1 -0.0 1.5 -2.1 1.2 -0.4
Leg fat mass (right) 0.5 1.9 5.5 -2.4 2.3 -0.2 2.3 -0.6 0.2 0.9 -0.7 -1.0 -0.7 -0.6 0.9 -2.0 1.7 -0.5
Arm predicted mass (right) 0.2 1.1 4.0 0.2 2.0 0.4 1.2 0.5 0.2 1.2 1.9 -0.8 0.1 0.2 1.0 -0.2 1.8 0.8
Pulse rate, automated reading 0.3 1.1 4.6 0.8 -0.5 0.8 -0.3 0.0 -1.7 -0.9 0.7 -0.9 -1.5 -2.1 -1.1 0.6 0.4 -1.1
Alcohol intake frequency. 1.6 3.7 16.0 -1.7 -1.4 -1.9 -0.9 -2.5 -1.2 -1.9 -4.0 -1.5 -2.2 -2.2 -1.5 -1.6 0.1 -1.5
Comparative height size at age 10 0.1 0.8 4.4 -0.7 2.1 0.5 0.8 1.4 0.4 0.8 0.9 0.2 -0.1 -0.6 0.6 -0.2 -0.6 -0.9
Number of full sisters 1.0 1.2 4.1 -1.2 0.5 0.5 0.4 -1.3 0.4 0.6 1.9 -2.0 -1.0 -0.8 -0.6 -1.9 1.1 -0.1
Suffer from ‘nerves’ 0.4 0.6 3.0 0.4 -0.0 0.2 -0.2 -0.8 -0.2 0.4 0.0 -1.3 -1.1 -0.4 -1.7 0.6 -0.1 -1.1
Overall health rating 0.7 1.4 6.4 -1.3 0.5 2.5 1.9 0.3 0.1 0.5 0.1 1.0 0.0 -0.4 0.9 -1.6 1.8 1.1
Chest pain or discomfort 1.4 2.0 6.1 -2.5 1.1 1.5 1.8 -0.6 1.5 2.2 2.1 -1.3 0.3 0.7 -0.2 -1.1 -0.8 -1.2
Had major operations 1.3 1.5 7.1 -2.2 1.0 2.7 0.2 -0.8 1.8 1.7 0.5 -0.1 0.4 0.6 0.4 -1.3 0.2 -0.6
Age at last live birth 1.7 2.4 6.7 -0.3 1.2 0.7 2.3 1.6 1.1 2.3 1.7 -0.4 2.6 2.1 2.0 -0.1 0.1 1.6
Family relationship satisfaction 0.7 0.9 2.2 -1.5 1.4 0.8 1.4 0.0 1.0 1.1 0.9 -0.6 1.0 0.7 -0.2 -0.1 -1.0 -1.0
Leg pain on walking 0.7 0.8 3.0 -1.7 0.2 1.0 0.5 -0.9 1.0 0.0 1.4 -0.7 0.0 -0.0 -0.8 -1.7 -0.5 -0.5
Qualifications: NVQ or HND or HNC or equivalent 0.8 0.9 2.8 -0.5 0.2 1.3 -0.1 -0.1 0.5 0.8 1.0 1.3 0.1 -0.0 1.3 -1.7 1.1 1.6
Commuting to job workplace: Car/motor vehicle 1.2 1.4 5.0 -2.2 1.2 1.0 0.4 -1.7 0.2 0.8 0.9 -1.4 -0.9 -0.8 -0.0 -2.0 1.2 0.1
Illness, injury, bereavement, stress in last 2 years 1.2 1.4 7.0 2.6 0.3 -1.0 -1.2 0.8 -0.8 -0.9 0.9 0.2 -0.6 -0.1 -1.3 2.1 -1.6 -0.4
Medication: Aspirin 0.7 1.0 3.3 -1.8 1.4 -0.5 1.4 -0.9 0.9 0.5 0.5 0.6 0.1 0.6 0.8 -1.3 1.5 0.2
Supplements: Vitamin C 0.3 0.3 1.8 0.1 -0.1 -1.0 -0.0 -0.3 -0.4 -0.2 0.8 -0.2 -0.5 -0.5 -0.7 -0.5 1.4 0.4
Knee pain experienced in last month 0.9 1.4 4.6 -1.9 0.7 1.3 0.6 -0.1 1.6 1.3 0.3 2.1 1.2 1.2 0.6 -1.4 -0.2 0.5
Hypertension (Self-reported) 0.7 2.0 6.7 -0.1 -2.6 0.4 -1.9 -0.9 -1.2 -2.3 -2.2 0.3 -1.0 -1.7 0.2 0.7 1.5 -1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 1.0 5.3 0.3 -0.4 -0.8 0.4 0.1 -0.1 -0.6 -0.9 -0.3 -0.8 -0.3 -1.4 1.4 -1.4 -2.3
Illnesses of father: Heart disease 1.2 1.7 6.0 2.1 0.7 1.9 0.4 2.3 -0.2 0.7 1.0 0.8 0.7 0.6 1.1 0.4 1.0 2.4
Illnesses of siblings: Diabetes 0.4 0.5 3.8 -1.3 0.2 0.3 0.5 -0.7 0.6 0.1 -0.2 0.2 0.2 0.2 0.1 -2.0 -0.2 0.9
Smoking status: Previous 1.3 1.9 6.7 -0.6 1.5 -0.3 2.6 1.9 1.2 1.4 1.4 0.1 1.8 1.8 1.4 -0.1 1.0 0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.8 9.9 1.2 1.4 1.1 1.0 3.1 0.3 1.4 2.0 0.4 1.3 0.6 0.9 0.7 -0.9 0.9
Whole body fat-free mass 0.2 1.1 4.8 0.0 1.8 -0.2 1.0 0.1 0.2 1.2 2.2 -0.6 0.2 0.2 1.0 -0.6 1.6 0.9
Leg fat-free mass (right) 0.5 2.5 8.5 -1.3 2.9 -0.2 2.0 0.6 1.2 2.1 2.3 -0.3 0.9 0.8 1.9 -1.6 1.5 1.1
Arm fat percentage (left) 0.8 3.1 14.0 -3.7 2.3 0.1 2.7 -0.8 1.2 1.5 -1.1 -0.4 -0.5 -0.2 1.6 -3.0 1.3 -0.5
Average weekly red wine intake 0.4 0.6 2.9 1.0 -0.6 -1.7 -0.9 -0.5 -0.1 -0.3 0.0 -1.0 0.7 0.9 -0.4 1.2 0.3 0.4
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.9 0.3 0.4 -0.1 -0.6 -1.0 -0.5 -0.3 1.0 -1.4 -1.0 -0.5 -1.1 0.5 -0.2 -0.6
Mood swings 1.2 2.2 7.3 -2.7 2.0 -0.0 1.7 -2.4 0.9 1.9 -0.0 -1.7 -0.8 -0.1 -0.7 -1.6 0.0 -1.3
Loneliness, isolation 1.0 1.4 5.6 -1.7 2.4 0.9 1.7 -0.2 1.4 1.5 0.9 0.3 1.2 1.4 0.0 -0.9 0.1 0.4
Long-standing illness, disability or infirmity 1.2 1.8 4.9 -2.2 0.4 0.7 2.0 -0.5 0.7 0.8 0.0 -0.4 1.5 1.1 1.5 -2.0 2.2 1.6
Ever had bowel cancer screening 0.5 0.5 3.4 0.8 0.1 0.0 1.1 0.6 0.1 -0.2 0.3 0.1 0.1 0.5 0.2 1.8 0.3 -1.4
Diabetes diagnosed by doctor 0.3 0.4 2.3 -0.9 0.3 1.5 -0.3 0.2 -0.0 -0.5 -0.3 -0.3 0.2 -0.3 0.2 -0.8 1.0 0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.5 0.7 -0.2 -1.2 -0.3 0.5 0.2 -0.2 1.0 -1.2 0.5 0.7 0.6 -0.1 0.8 1.1
Friendships satisfaction 1.2 1.5 8.8 -3.0 1.2 0.1 1.0 -2.1 0.8 0.7 1.5 -0.4 0.6 0.1 -0.8 -1.3 -0.5 -0.9
Qualifications: nursing, teaching 0.6 0.9 4.6 1.7 -0.4 -0.2 -1.0 0.7 -1.2 -1.0 -0.7 0.3 -0.3 -0.6 -0.2 2.1 -0.5 -0.6
Commuting to job workplace: Walk 0.9 1.0 3.4 -0.5 -0.9 0.4 0.8 1.6 1.3 1.1 0.2 0.7 1.3 1.3 1.8 -0.3 -0.2 0.4
Eye problems/disorders: Cataract 1.3 1.5 6.2 0.7 -1.1 -1.4 -1.3 -1.0 -0.8 -0.9 -2.5 -0.7 -1.2 -0.8 -1.8 -0.5 1.2 0.5
Mouth/teeth dental problems: Mouth ulcers 1.2 1.9 5.9 -0.4 -1.2 -1.7 -1.0 -2.4 -1.2 -1.0 -0.3 -1.9 -1.9 -1.4 -1.3 -1.2 1.5 -0.3
Medication for cholesterol 0.5 0.8 3.4 0.2 1.8 -1.1 -0.3 -0.5 -0.9 0.1 1.0 -0.6 -0.9 -0.5 -1.0 -0.8 0.2 1.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.6 3.0 7.6 1.2 -2.1 -1.6 -2.2 -2.8 -1.6 -2.4 -0.5 -0.8 -1.8 -1.3 -2.3 1.5 1.2 -1.3
Back pain experienced in last month 2.6 3.8 10.1 -1.4 1.9 3.2 2.8 1.9 1.9 3.0 1.1 0.7 2.0 1.8 1.7 -1.4 0.5 1.5
Mineral and other dietary supplements 0.3 0.4 2.3 -0.6 -0.3 0.3 0.3 -0.1 0.6 0.3 -0.3 0.6 0.9 0.6 1.5 0.3 -0.3 -1.0
Breast cancer (self-reported) 0.6 0.7 3.1 1.3 0.1 0.8 0.1 1.8 0.3 0.3 0.3 0.8 0.6 0.8 -0.2 1.3 -1.0 -0.2
Asthma (self-reported) 1.8 3.6 9.1 -1.7 1.7 1.8 3.0 0.9 1.9 2.3 1.4 -0.2 1.8 1.8 2.8 -1.5 2.3 1.7
Osteoporosis (self-reported) 0.1 0.2 1.0 0.2 -0.3 0.5 -0.4 -0.1 -0.1 -0.2 -0.2 -0.5 -0.5 -0.2 0.2 0.6 1.0 -0.4
Osteoarthritis (self-reported) 1.0 1.3 6.3 -2.5 0.9 1.5 0.7 -0.9 0.9 1.2 0.3 -0.1 -0.2 -0.2 0.0 -2.2 1.2 0.0
Medication: Aspirin 0.5 0.7 2.6 -1.6 0.7 -0.5 1.1 -1.1 0.7 0.1 -0.1 0.4 -0.1 0.3 0.5 -1.1 1.4 -0.2
Medication: Gliclazide 2.2 2.4 6.8 -2.2 1.4 1.5 2.6 1.1 2.1 2.0 0.5 0.6 1.9 1.7 1.0 -1.4 -0.9 0.3
Illnesses of father: None of the above (group 1) 1.3 1.6 5.0 -0.3 0.0 -2.1 -1.0 -1.5 -0.8 -1.3 -0.2 -0.7 -1.1 -1.0 -2.2 0.3 -1.9 -1.8
Smoking status: Current 2.0 3.2 13.4 -3.6 0.1 1.6 -0.5 -2.2 0.6 0.8 -1.4 -1.7 -1.7 -1.5 -1.2 -3.7 -0.2 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.8 3.7 9.9 -0.8 3.2 1.4 1.4 1.8 2.8 1.8 1.8 0.6 2.8 2.8 2.0 -1.1 -0.9 1.6
Whole body water mass 0.2 1.0 4.2 -0.0 1.8 -0.2 1.0 0.2 0.2 1.2 2.1 -0.7 0.2 0.2 1.0 -0.5 1.6 0.8
Leg predicted mass (right) 0.4 2.3 8.1 -1.2 2.8 -0.2 2.0 0.6 1.1 2.0 2.3 -0.3 0.8 0.7 1.8 -1.5 1.5 1.0
Arm fat mass (left) 0.5 2.0 7.1 -2.7 2.1 0.2 2.2 -0.6 0.6 1.2 -0.3 -0.8 -0.7 -0.5 1.3 -2.3 1.3 -0.3
Number of self-reported non-cancer illnesses 0.6 1.0 2.9 -1.1 -1.5 0.2 -0.5 -1.3 -0.0 -0.7 -1.3 -1.6 -0.8 -0.6 -0.8 -0.1 0.8 -1.7
Average weekly champagne plus white wine intake 0.4 0.6 1.5 0.6 -0.3 -0.5 -0.1 -0.6 -1.2 -0.1 0.8 -0.3 -1.2 -1.1 -0.5 0.9 0.4 -1.0
Miserableness 0.7 1.1 3.9 0.8 -0.3 -0.7 -0.7 -1.0 -0.9 -0.9 1.0 -1.1 -1.6 -1.2 -2.0 1.0 0.8 -1.1
Guilty feelings 1.7 2.6 6.3 -0.2 2.2 1.5 1.5 1.5 2.1 1.9 2.5 1.2 2.0 2.0 1.5 0.4 0.6 0.4
Wears glasses or contact lenses 1.3 1.5 5.3 0.9 0.5 -1.2 1.0 2.3 0.3 0.7 0.8 -0.1 1.7 1.6 2.3 0.9 0.4 0.9
Ever taken oral contraceptive pill 1.1 1.2 2.6 -1.2 1.6 1.1 1.0 0.7 1.4 1.2 0.7 1.5 1.1 0.9 1.1 -1.2 -0.1 0.6
Hearing aid user 0.9 1.0 4.0 -0.9 0.6 1.3 -0.0 -0.8 1.1 1.2 2.0 -0.1 0.0 0.2 0.4 -1.9 0.5 1.0
Mother’s age at death 1.0 1.3 5.0 0.5 -0.4 -2.2 -0.7 -0.7 -0.8 0.0 -0.1 -1.6 -0.8 -1.0 -1.9 0.7 -1.3 -1.5
Financial situation satisfaction 3.1 3.9 12.4 -2.6 2.0 0.1 3.5 1.0 1.5 2.8 1.4 -0.2 1.1 1.1 2.4 -3.1 1.2 1.6
Tinnitus: Yes, now most or all of the time 0.4 0.4 1.8 -1.0 0.2 -0.4 -0.3 -1.2 0.7 -0.0 1.3 0.2 0.4 0.7 0.1 0.0 -0.4 -0.6
Commuting to job workplace: Public transport 0.9 1.1 4.1 0.5 0.1 0.2 0.9 1.5 0.3 -0.2 -0.0 2.0 1.9 1.3 1.4 0.5 0.4 0.7
Eye problems/disorders: Glaucoma 0.4 0.4 2.1 -1.2 -0.1 -0.7 0.2 -1.2 0.2 -0.1 -1.4 0.6 0.3 0.3 -0.1 -0.7 0.2 0.2
Medication: Blood pressure 0.4 0.8 3.2 0.4 -1.3 0.7 -0.5 0.5 0.0 -0.7 -1.3 1.8 0.4 -0.2 0.7 1.3 0.3 -1.2
Pain type(s) experienced in last month: Hip pain 0.7 0.9 4.4 -2.1 0.2 1.8 0.9 -0.4 0.7 0.8 0.2 -0.8 -0.4 -0.6 0.2 -1.4 0.5 -0.6
Supplements: Fish oil (including cod liver oil) 0.6 0.8 2.5 -0.9 1.6 0.3 1.3 0.0 0.7 1.2 0.9 0.0 0.4 0.8 -0.2 -1.3 0.3 1.3
High cholesterol (Self-reported) 0.8 1.5 4.1 -2.0 0.8 1.1 1.5 -0.6 1.4 0.7 0.5 -1.0 0.8 1.0 1.5 -1.8 1.6 0.6
Medication: Bendroflumethiazide 0.4 0.6 2.4 -0.2 -0.3 -1.0 -0.3 -1.1 -0.8 -1.0 -1.3 0.2 -0.5 -0.6 0.6 0.3 1.6 -0.4
Medication: Paracetamol 0.8 1.2 3.6 -0.1 -0.1 -0.4 -0.5 -1.7 -0.6 -0.2 0.1 -1.9 -1.8 -1.3 -1.4 0.1 1.2 -1.4
Medication: Lisinopril 0.5 0.6 2.7 -1.6 -0.4 0.5 0.8 -0.5 0.3 0.3 -0.8 1.2 1.0 0.2 0.8 -1.2 -0.3 0.3
Medication: Atorvastatin 1.1 1.3 4.5 -0.7 0.0 1.6 0.5 0.9 1.7 0.7 0.6 0.6 1.7 1.2 2.1 -1.1 0.7 1.2
Illnesses of father: High blood pressure 1.7 2.1 5.5 1.8 -2.3 -1.3 -1.7 -0.2 -2.0 -2.2 0.3 0.9 -1.3 -1.6 -0.7 1.6 -0.8 -0.8
Alcohol drinker status: Never 1.6 1.9 6.0 -1.6 -0.7 -0.3 0.0 -2.5 -0.4 -0.4 -1.1 -2.3 -1.8 -1.3 -1.5 -1.3 0.1 -1.9
Ever smoked 0.8 1.5 5.9 -2.4 1.0 0.6 1.6 0.5 1.3 1.6 0.9 0.4 0.6 0.7 1.3 -1.9 0.6 0.3
Basal metabolic rate 0.2 1.0 3.9 -0.3 2.0 -0.3 1.2 0.1 0.1 1.2 1.9 -0.8 -0.1 -0.1 0.9 -0.7 1.6 0.5
Leg fat percentage (left) 0.4 1.4 5.7 -1.9 1.8 -0.0 2.4 -0.3 0.3 0.7 -1.5 -0.5 -0.5 -0.3 0.9 -1.2 1.4 -0.7
Arm fat-free mass (left) 0.1 0.7 2.9 1.3 0.8 -0.3 0.3 0.3 -0.9 0.1 1.3 -0.8 -0.6 -0.7 0.2 0.6 1.7 0.3
Number of operations (self-reported) 0.8 1.3 5.9 -2.1 -0.2 1.3 1.5 0.5 1.0 1.0 -1.4 0.4 -0.0 -0.1 0.2 -2.4 -0.3 0.2
Average weekly beer plus cider intake 1.1 1.6 6.1 -1.8 1.2 1.8 0.7 -0.3 0.9 0.8 2.5 0.5 0.3 0.2 0.7 -2.4 -0.9 1.0
Irritability 0.7 1.2 6.1 -0.5 -0.2 -1.8 0.0 -2.5 -0.6 -0.2 0.6 -1.4 -1.5 -0.6 -1.6 -0.2 0.8 -0.6
Risk taking 0.2 0.4 2.0 -0.6 0.9 -0.3 -0.1 -0.8 -0.1 0.1 0.4 -1.4 -0.3 -0.3 0.0 -0.2 0.7 -0.6
Ever had prostate specific antigen (PSA) test 0.2 0.2 1.0 -0.3 1.0 0.6 0.3 -0.6 -0.1 -0.1 0.2 -0.7 0.1 0.2 0.1 0.5 -0.2 -0.5
Fractured/broken bones in last 5 years 0.2 0.2 0.9 -0.4 -0.6 -1.0 -0.1 -0.4 -0.7 -0.4 -0.2 0.5 -0.6 -0.2 -0.3 0.2 0.2 -0.3
Age started oral contraceptive pill 2.1 2.6 7.4 0.9 -0.7 -2.0 -1.8 -2.1 -1.6 -2.0 -0.6 -1.2 -2.1 -2.1 -2.7 0.1 -0.1 -1.1
Diastolic blood pressure, automated reading 0.7 2.3 6.6 0.9 -2.0 -0.7 -1.6 -1.5 -2.1 -2.6 -1.7 -0.7 -1.5 -2.0 -0.5 1.4 0.3 -1.2
Ever depressed for a whole week 1.3 1.6 3.7 1.4 -1.6 -0.8 -1.9 0.3 -1.5 -1.9 -1.9 0.4 -0.1 -0.8 0.2 1.0 1.6 0.9
Unable to work because of sickness or disability 0.8 1.0 4.8 -1.6 0.4 2.2 0.2 -0.3 0.4 0.2 -0.2 0.8 0.5 0.1 0.4 -1.9 -0.9 1.2
Commuting to job workplace: Cycle 1.2 1.5 4.1 0.6 -1.4 -2.0 -1.0 -1.3 -1.8 -1.1 -0.9 -1.1 -1.5 -1.7 -0.8 0.2 0.5 -0.6
Myopia 2.2 3.2 6.8 0.4 1.7 -1.2 1.8 2.3 1.6 1.4 2.5 2.2 2.5 2.6 2.1 0.4 -1.0 0.8
Vascular/heart problems diagnosed by doctor 0.8 2.3 9.2 -0.2 3.0 -0.2 1.9 1.0 1.2 2.1 2.1 0.6 1.3 1.7 0.3 -1.0 -0.9 1.8
Cholesterol lowering medication 1.2 1.7 5.0 -0.9 -0.4 2.2 2.1 1.1 1.9 1.1 -0.7 -0.1 1.7 1.7 1.6 -0.0 0.0 -0.7
Medication: Omeprazole (e.g. Zanprol) 0.8 0.9 4.0 -1.3 1.3 1.0 2.0 0.3 0.8 1.4 -0.2 0.6 -0.1 0.3 0.6 -0.7 -0.5 -1.0
Pain experienced in last month 0.7 1.1 4.7 2.2 -1.0 -1.2 -1.7 0.2 -1.4 -1.4 -0.1 0.1 -0.3 -0.8 0.4 1.2 0.3 0.4
Supplements: Calcium 0.2 0.2 0.8 0.1 -0.3 -0.9 0.3 0.0 -0.6 -0.3 -0.7 -0.9 -0.3 -0.2 -0.4 -0.1 -0.5 0.2
Basal cell carcinoma (self-reported) 0.9 1.1 3.2 -1.4 1.0 0.3 1.8 -0.2 1.2 1.8 0.7 -0.3 0.6 1.2 0.2 -1.0 -1.3 -0.2
Heart attack/myocardial infarction (self-reported) 0.6 0.8 2.2 -0.1 -0.6 1.2 -0.3 -0.0 -0.1 0.3 -0.4 -1.1 -1.1 -1.0 -1.5 0.1 -1.5 -1.3
Deep venous thrombosis (DVT) (self-reported) 0.8 1.1 3.4 -0.2 0.7 1.1 -0.0 0.2 1.8 0.9 -1.2 -0.5 1.7 1.8 0.8 1.0 -0.7 -0.3
Heart disease (siblings) 0.4 0.5 5.0 -0.2 -0.1 0.7 -0.2 -0.3 -0.2 -0.1 0.2 -2.2 -0.4 -0.3 0.2 0.5 1.2 -0.2
Alcohol drinker status: Previous 0.6 0.7 3.6 -0.5 -1.1 -0.0 0.2 0.7 -0.1 -0.9 -0.6 1.9 1.0 0.1 1.1 -0.0 -1.0 0.5
Pack years of smoking 1.2 1.8 7.1 -0.8 -0.5 0.2 -0.9 -2.7 -0.5 -0.7 0.3 -0.9 -2.4 -1.8 -1.6 -0.6 0.9 -1.8
Impedance of whole body 0.3 1.6 6.3 0.2 0.0 1.1 0.1 2.2 1.1 1.1 -0.2 0.1 0.8 0.8 -0.6 2.0 -2.5 -1.8
Leg fat mass (left) 0.5 1.8 5.8 -2.1 2.4 -0.1 2.4 -0.5 0.3 1.0 -0.5 -1.0 -0.6 -0.5 0.9 -1.8 1.7 -0.4
Arm predicted mass (left) 0.1 0.5 2.4 1.0 0.9 0.0 0.2 0.1 -0.7 0.2 1.3 -0.6 -0.6 -0.7 0.2 0.3 1.6 0.3