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chr1:228,715,705-232,181,815

Best TWAS P=1.01e-36 · Best GWAS P=4.25e-32 conditioned to 3.35e-08

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
18	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EGLN1	0.07	0.02	blup	64	0.04	3.5e-03	-11.4	-12.7	1.0e-36	0.87	0.05	0.67	TRUE
7	GTEx	Skin Not Sun Exposed Suprapubic	ARV1	0.14	-0.01	lasso	4	0.00	5.0e-01	-2.2	7.9	3.3e-15	-0.18	0.11	0.21	TRUE
14	YFS	Blood	TAF5L	0.01	0.02	lasso	1	0.01	1.8e-05	6.0	-6.0	2.2e-09	-0.02	0.01	0.99	TRUE
2	GTEx	Adipose Subcutaneous	C1orf131	0.11	0.00	enet	24	0.04	6.5e-04	10.2	5.5	4.7e-08	-0.26	0.06	0.36	TRUE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	C1orf124	0.05	0.01	blup	44	0.03	5.3e-04	-11.4	-11.6	6.9e-31	0.82	0.01	0.96	FALSE
20	The Cancer Genome Atlas	Lung Adenocarcinoma	C1orf124	0.02	0.02	lasso	2	0.01	8.8e-03	-11.1	-11.5	1.7e-30	0.97	0.01	0.86	FALSE
23	The Cancer Genome Atlas	Prostate Adenocarcinoma	EGLN1	0.02	0.02	lasso	1	0.01	1.4e-02	-11.4	-11.4	3.1e-30	0.97	0.03	0.83	FALSE
25	The Cancer Genome Atlas	Soft Tissue Sarcoma	C1orf124	0.04	0.04	enet	7	0.05	5.2e-04	-11.7	-11.4	5.4e-30	0.97	0.02	0.92	FALSE
10	NTR	Blood	C1orf124	0.05	0.06	lasso	3	0.07	3.1e-21	-11.4	-11.3	1.8e-29	0.97	0.04	0.96	FALSE
4	GTEx	Esophagus Mucosa	SPRTN	0.06	0.05	lasso	3	0.02	1.8e-02	-11.3	-11.3	2.1e-29	0.97	0.06	0.88	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	C1orf124	0.03	0.02	blup	44	0.02	3.3e-04	-11.8	-11.2	5.8e-29	0.97	0.01	0.98	FALSE
16	The Cancer Genome Atlas	Colon Adenocarcinoma	C1orf124	0.04	0.03	blup	44	0.04	1.9e-03	-11.1	-11.2	6.9e-29	0.98	0.03	0.71	FALSE
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	C1orf124	0.08	0.05	blup	44	0.04	2.8e-05	-11.8	-11.1	1.8e-28	0.97	0.01	0.99	FALSE
8	GTEx	Testis	SPRTN	0.10	0.08	lasso	6	0.05	3.0e-03	-11.4	-10.8	2.3e-27	0.91	0.07	0.89	FALSE
26	The Cancer Genome Atlas	Thyroid Carcinoma	C1orf124	0.04	0.05	enet	7	0.06	3.8e-06	-11.4	-10.8	4.9e-27	0.98	0.02	0.98	FALSE
12	YFS	Blood	EXOC8	0.06	0.08	lasso	3	0.08	8.2e-26	-10.2	-10.0	1.5e-23	0.83	1.00	0.00	FALSE
3	GTEx	Cells Transformed fibroblasts	SPRTN	0.05	0.02	enet	8	0.01	3.2e-02	-10.8	-8.7	2.7e-18	0.71	0.04	0.77	FALSE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EGLN1	0.04	0.04	blup	64	0.03	8.9e-05	-1.9	7.3	3.4e-13	-0.83	0.17	0.75	FALSE
24	The Cancer Genome Atlas	Rectum Adenocarcinoma	EXOC8	0.16	0.03	enet	8	0.04	3.5e-02	-10.8	7.2	5.0e-13	-0.79	0.01	0.29	FALSE
5	GTEx	Heart Atrial Appendage	GNPAT	0.13	0.00	lasso	5	0.01	1.7e-01	-2.9	6.7	2.4e-11	-0.58	0.06	0.38	FALSE
11	YFS	Blood	ARV1	0.05	0.05	lasso	4	0.05	4.8e-16	-6.0	5.8	4.9e-09	-0.05	1.00	0.00	FALSE
6	GTEx	Nerve Tibial	ARV1	0.10	0.02	enet	17	0.02	1.3e-02	-4.2	5.7	1.4e-08	-0.08	0.45	0.02	FALSE
9	GTEx	Testis	TTC13	0.32	0.19	lasso	3	0.23	1.5e-10	-6.1	-5.4	5.5e-08	0.03	1.00	0.00	FALSE
13	YFS	Blood	NUP133	0.02	0.00	bslmm	431	0.01	2.8e-03	3.7	-5.3	9.6e-08	0.04	0.63	0.05	FALSE
1	CommonMind	Brain Pre-frontal Cortex	RAB4A	0.04	0.00	blup	489	0.02	2.0e-03	6.3	-5.2	2.0e-07	0.06	0.02	0.83	FALSE
21	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TTC13	0.04	0.04	blup	90	0.03	3.0e-03	-4.1	5.2	2.3e-07	-0.08	0.02	0.82	FALSE