Hub : Genes

TTC13

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1280	0.0460	1.7e-03	0.021	NA	0.027	NA	0.037	2.4e-02	NA	1.2e-02	NA	3.8e-03
2	GTEx	Colon Transverse	0.1080	0.0450	9.2e-03	0.082	NA	0.108	NA	0.099	9.6e-05	NA	8.3e-06	NA	1.9e-05
3	GTEx	Skin Not Sun Exposed Suprapubic	0.1370	0.0460	1.2e-03	0.120	NA	0.070	NA	0.079	4.2e-07	NA	1.1e-04	NA	4.3e-05
4	GTEx	Skin Sun Exposed Lower leg	0.1270	0.0380	1.3e-04	0.083	NA	0.070	NA	0.076	2.3e-07	NA	2.0e-06	NA	7.2e-07
5	GTEx	Testis	0.3190	0.0700	7.9e-07	0.191	NA	0.204	NA	0.230	6.8e-09	NA	2.0e-09	NA	1.5e-10
6	METSIM	Adipose	0.0763	0.0231	2.8e-06	0.062	0.053	0.058	0.057	0.057	1.5e-09	2.2e-08	4.9e-09	6.8e-09	5.7e-09
7	YFS	Blood	0.0174	0.0085	1.3e-02	0.004	0.002	0.002	0.004	0.002	1.2e-02	5.8e-02	7.1e-02	1.8e-02	7.7e-02
8	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0750	0.0490	9.5e-03	0.010	0.027	0.013	NA	0.009	8.0e-02	1.0e-02	5.7e-02	NA	9.8e-02
9	TCGA	Ovarian Serous Cystadenocarcinoma	0.0430	0.0260	5.6e-03	0.036	0.032	0.013	NA	0.026	1.7e-03	3.0e-03	4.2e-02	NA	6.5e-03
10	TCGA	Thyroid Carcinoma	0.1160	0.0460	1.6e-09	0.079	0.099	0.080	NA	0.087	3.7e-08	7.7e-10	3.0e-08	NA	7.4e-09

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	1.3	2.0	4.0	-1.0	-1.2	-1.6	-0.8	1.6	-1.4	-1.1	-2.0	-1.5	-1.6
Bipolar Disorder or Schizophrenia	0.1	0.3	1.6	-0.5	-0.0	-0.7	-0.2	0.3	-0.6	-0.1	-1.3	-0.3	-0.6
Depressed Affect (Nagel 2018)	0.3	0.5	1.7	0.4	0.7	0.7	1.0	-1.0	1.3	0.3	-0.4	0.6	0.2
Depression (Nagel 2018)	2.1	3.1	5.9	1.5	1.6	1.9	1.5	-2.4	0.8	2.0	0.9	2.2	2.1
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.8	-1.5	-0.3	-1.3	-1.7	0.3	-0.5	-0.9	-0.6	-0.2	-0.5
Neuroticism (Nagel 2018)	0.4	1.0	2.3	0.7	1.0	1.2	1.0	-1.1	1.5	1.0	-0.0	1.1	0.3
Schizophrenia (2018)	0.2	0.4	0.8	0.1	0.9	0.5	0.4	-0.8	0.3	0.8	-0.0	0.8	0.5
Schizophrenia vs Biploar Disorder	0.4	0.5	1.3	0.4	0.6	0.6	0.2	-1.1	0.5	0.5	0.4	1.0	1.0
Worry (Nagel 2018)	1.2	2.4	4.5	1.3	1.7	1.3	1.0	-2.0	1.3	2.1	1.0	2.1	1.1
Alzheimer’s Disease (in mother)	0.3	0.3	1.4	-0.1	0.1	-0.2	-0.1	1.2	-0.3	-0.6	-0.9	-0.5	-0.6
Alzheimer’s Disease (in father)	0.3	0.3	0.7	0.1	0.4	0.6	0.9	-0.2	-0.4	0.5	0.8	0.3	0.7
Alzheimer’s Disease (including proxy)	0.1	0.1	0.7	-0.1	0.6	-0.0	0.2	0.4	-0.8	-0.1	-0.2	-0.0	-0.1
Crohns Disease (2017)	0.3	0.7	2.0	-0.8	-1.4	-0.6	-1.0	0.3	-0.9	-0.9	-0.8	-0.5	-0.8
Irritable Bowel Disease (IBD)	0.4	0.8	3.0	-0.8	-1.7	-0.5	-0.6	-0.3	-1.2	-1.1	-1.0	-0.3	-0.7
Ulcerative Colitis (UC)	0.2	0.4	1.2	-0.3	-1.1	-0.1	0.2	-0.5	-1.0	-0.7	-0.7	-0.1	-0.5
Major Depression (MDD)	0.4	0.5	1.6	-0.9	-0.4	-0.9	-0.6	0.7	-0.6	-0.4	-1.3	0.1	0.5
Reaction Time	0.1	0.2	0.9	0.2	0.8	-0.1	-0.1	0.3	-0.1	0.9	0.6	0.1	0.2
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.3	-1.5	-0.8	-1.1	-1.5	0.5	0.1	-1.3	-0.8	-0.3	-0.6
Breast Cancer	0.2	0.4	1.2	-0.5	-0.5	-0.5	-0.6	1.1	-0.1	0.2	1.0	-0.9	0.1
Ovarian Cancer	3.1	4.1	5.6	2.3	1.8	1.8	1.8	-2.0	1.5	1.9	2.2	2.3	2.4
Prostate Cancer	0.1	0.1	0.6	-0.2	0.1	-0.4	-0.1	0.2	0.7	0.1	-0.4	0.1	-0.5
Age at First Birth	0.5	0.7	3.1	0.4	0.2	0.3	0.3	-1.8	-0.2	1.3	0.5	1.0	1.0
Bipolar Disorder (2011)	1.7	1.7	2.9	-1.4	-1.4	-1.4	-1.2	1.0	-1.7	-1.0	-1.6	-0.9	-1.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.6	0.5	-0.1	0.4	-0.1	-0.3	-0.1	-0.4	0.8	-0.2	0.1
Coronary Artery Disease (CAD)	6.0	7.2	11.7	-3.4	-2.1	-2.6	-2.4	3.4	-2.1	-1.8	-2.2	-3.2	-3.0
Crohns Disease (2012)	0.2	0.3	0.7	-0.4	-0.8	-0.5	-0.8	0.3	-0.0	-0.7	-0.5	0.2	-0.4
Mean Putamen Volume	0.4	0.5	1.4	0.4	0.7	0.3	0.3	-1.1	0.6	0.5	1.2	0.5	0.6
Fasting Glucose	0.3	0.4	1.3	-0.5	0.1	-0.7	-0.4	1.0	0.1	-0.3	-1.1	-0.3	-0.5
HbA1C	0.3	0.4	1.6	0.0	-0.9	-0.1	-0.6	-0.5	-1.3	-0.4	-0.7	-0.1	-0.2
HDL Cholesterol	0.9	1.5	3.0	-1.6	-0.4	-1.7	-1.6	1.2	-0.7	-0.7	-1.3	-1.2	-1.2
LDL Cholesterol	0.3	0.5	1.5	-0.2	-0.4	-0.2	-0.1	1.1	0.1	-0.6	-0.8	-1.2	-1.1
Lupus	0.6	0.9	2.0	1.0	0.8	1.3	1.4	-0.2	0.7	0.4	1.3	0.4	0.9
Neuroticism (2016)	1.5	2.1	5.2	-1.8	-1.3	-1.1	-1.2	0.9	-0.4	-1.8	-2.3	-1.0	-1.8
Primary Biliary Cirrhosis	4.0	5.7	10.0	-1.9	-1.9	-2.4	-1.8	2.5	-2.3	-2.6	-3.2	-2.3	-2.8
Rheumatoid Arthritis	0.1	0.1	0.3	-0.1	0.4	0.1	0.0	-0.6	0.5	0.2	-0.3	0.4	-0.1
Schizophrenia (2014)	0.1	0.2	0.7	-0.6	-0.1	-0.6	-0.4	0.4	-0.6	0.1	-0.8	-0.1	-0.4
Triglycerides	0.7	1.2	2.6	1.5	0.4	1.6	1.0	-1.1	0.8	0.3	1.3	1.1	1.1
Type 2 Diabetes (T2D) (2012)	3.5	4.1	7.7	-1.9	-1.3	-2.0	-1.8	2.4	-2.3	-1.5	-1.5	-2.8	-2.2
Ulcerative Colitis	0.3	0.4	1.1	-0.1	-1.1	-0.0	-0.1	-1.1	-0.6	-0.4	-0.8	0.8	0.4
Blood Eosinophil Count	1.0	7.8	10.8	2.5	2.7	3.2	3.3	-2.8	2.6	2.8	2.3	2.9	2.8
Blood Platelet Count	1.0	12.1	21.0	-3.6	-3.1	-3.0	-2.0	3.6	-2.3	-3.7	-4.6	-4.0	-4.0
Blood Red Count	1.6	15.6	29.6	3.8	2.5	3.8	3.3	-5.4	0.2	4.6	3.2	5.2	4.7
Blood White Count	0.8	5.9	9.9	3.1	1.9	2.7	2.4	-2.5	2.0	2.0	2.6	2.5	2.4
Heel T-Score	0.7	5.3	8.0	2.5	1.5	2.4	2.5	-2.8	1.1	2.8	2.6	2.2	1.9
BMI	0.1	0.5	1.7	0.1	1.3	0.3	0.5	0.6	1.3	0.0	-0.4	0.3	0.7
Height	1.3	24.9	34.1	4.2	5.4	4.4	3.4	-4.2	5.8	5.8	5.6	5.5	5.0
Waist Hip Ratio (WHR)	0.7	2.9	5.7	1.8	1.9	2.4	2.3	-1.1	1.6	1.9	1.6	1.1	1.0
Systolic Blood Pressure	0.6	2.9	5.5	-2.4	-0.9	-2.3	-1.9	2.2	-0.8	-1.4	-0.3	-2.1	-1.5
Smoking Status	0.6	1.5	3.7	-1.0	-0.8	-0.9	-0.9	1.9	-1.1	-1.2	-0.6	-1.8	-1.4
Allergy or Eczema	1.1	2.9	5.6	0.6	1.9	1.3	1.3	-2.3	2.4	1.2	0.7	2.4	1.8
Cardiovascular Disease	0.4	1.3	4.8	-1.0	1.5	-0.9	-0.6	2.2	1.2	0.5	0.9	-0.9	-0.8
Hypothyroidism (self reported)	1.0	2.3	4.1	-1.6	-1.9	-1.2	-1.2	1.4	-1.3	-1.8	-0.9	-2.0	-1.4
Respiratory disease	1.1	2.4	4.4	-1.8	-1.4	-2.1	-2.1	0.2	-1.7	-2.0	-1.4	-0.7	-0.7
Type 2 Diabetes (T2D) (2018)	0.1	0.2	1.0	1.0	-0.2	0.5	0.3	-0.3	0.6	0.4	0.5	-0.3	0.1
Lung FEV1/FVC ratio	0.5	2.7	6.9	1.2	2.5	1.4	1.8	-0.7	2.1	2.6	1.2	0.5	0.4
Lung FVC	0.3	1.6	3.1	1.0	1.8	1.5	1.6	-0.9	1.3	1.5	0.7	1.3	0.8
Neuroticism	0.2	0.4	1.4	0.1	0.5	0.4	0.5	-0.8	1.2	0.5	-0.5	0.8	0.0
Chronotype (morning person)	0.8	1.9	3.3	1.2	1.7	1.4	1.2	0.2	1.6	1.8	1.7	0.9	1.1
Hair Pigment	0.0	1.1	3.9	-0.7	-1.5	-0.5	-0.5	0.1	-1.4	-1.1	-2.0	-0.3	-0.1
Tanning	0.2	2.1	6.2	-1.4	-1.0	-1.2	-1.3	2.5	-1.8	-0.7	-0.2	-1.6	-1.6
Hand grip strength (left)	0.4	1.1	2.6	1.2	1.2	1.1	0.7	-0.2	1.6	0.8	1.4	0.6	0.8
Number of treatments/medications taken	0.9	1.6	3.4	-1.7	-0.3	-1.5	-1.8	1.5	-0.8	-0.7	-1.0	-1.2	-1.1
Average weekly spirits intake	2.7	3.4	4.6	-1.9	-1.6	-1.7	-1.6	2.1	-2.1	-1.9	-1.5	-2.0	-1.9
Sensitivity / hurt feelings	0.6	1.1	2.8	-1.1	-0.9	-0.6	-0.7	1.3	0.5	-1.0	-0.9	-1.3	-1.7
Frequency of depressed mood in last 2 weeks	2.8	3.9	6.2	2.5	2.1	2.1	1.6	-1.9	1.2	2.4	1.8	2.0	1.9
Hearing difficulty/problems: Yes	0.4	0.5	1.7	0.3	0.7	0.3	0.4	-0.6	1.3	0.8	0.2	1.1	0.8
Relative age of first facial hair	0.2	0.4	1.3	1.1	-0.1	0.9	0.4	-0.4	-0.1	0.8	1.1	0.2	-0.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.5	-0.1	0.7	-0.5	-0.4	0.2	-0.6	0.7	-0.2	0.6	0.2
Ever used hormone-replacement therapy (HRT)	3.2	4.1	5.5	-2.3	-1.7	-2.2	-1.9	2.3	-1.1	-1.6	-2.0	-2.3	-2.3
Ever had hysterectomy (womb removed)	2.4	2.7	3.8	-1.7	-1.0	-1.9	-1.7	1.8	-0.9	-1.4	-1.8	-1.8	-1.9
Systolic blood pressure, automated reading	1.3	3.9	6.8	-2.6	-1.4	-2.4	-2.1	1.8	-1.5	-1.8	-1.9	-2.0	-1.9
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	3.2	1.5	0.7	1.4	1.3	-1.1	0.5	1.7	1.8	0.6	1.0
Angina	1.5	2.0	5.1	-1.2	-1.5	-1.2	-1.0	0.6	-1.2	-1.6	-2.3	-1.4	-1.6
Medication for hormone replacement therapy	4.2	4.7	6.9	-2.4	-1.9	-2.3	-2.6	2.5	-1.2	-2.1	-1.2	-2.4	-2.3
Vitamin and mineral supplements	0.3	0.4	1.3	-0.7	-0.3	-1.1	-1.1	0.0	-0.6	-0.2	-0.7	-0.2	-0.4
Supplements: Zinc	1.4	1.5	5.6	-0.9	-0.0	-1.2	-0.8	2.4	-0.4	-0.3	-1.7	-1.2	-1.3
Medication: Co-codamol	0.1	0.1	0.4	-0.1	-0.1	-0.0	-0.3	0.6	-0.3	-0.2	-0.3	0.1	-0.1
Medication: Metformin	1.5	2.1	4.4	-0.8	-2.1	-1.2	-1.5	1.3	-1.5	-1.2	-0.8	-2.0	-1.4
Diabetes (father)	0.6	0.7	1.4	1.0	0.2	1.0	1.2	-1.0	0.3	0.9	0.9	0.4	0.9
Diabetes (mother)	0.8	1.0	2.3	-1.3	-1.0	-1.3	-1.4	0.2	-0.8	-1.5	0.1	-0.7	-0.7
Severe depression (siblings)	0.1	0.2	0.4	-0.3	0.1	-0.5	-0.0	0.4	-0.4	0.0	-0.6	-0.6	-0.3
Pack years adult smoking proportion	1.3	2.0	4.3	-0.9	-1.4	-1.3	-1.0	1.8	-0.9	-1.2	-1.4	-2.1	-1.7
Impedance of leg (right)	0.6	2.9	8.8	1.9	0.1	1.4	1.0	-3.0	-0.0	0.8	2.2	2.0	2.0
Leg fat-free mass (left)	0.3	1.8	6.5	0.2	2.5	0.8	0.7	0.2	2.4	1.4	1.1	1.0	0.9
Trunk fat percentage	0.2	0.6	1.8	0.4	0.9	0.7	0.5	-1.0	0.4	0.4	0.6	1.1	1.3
Hand grip strength (right)	0.6	1.7	4.1	1.3	1.8	1.3	0.7	-0.3	1.6	1.0	2.0	1.1	1.1
Townsend deprivation index at recruitment	1.0	1.4	2.5	1.5	0.9	1.0	1.2	-1.3	0.5	0.9	1.6	1.1	1.4
Current tobacco smoking	0.3	0.5	1.7	1.0	0.7	0.9	0.7	0.4	-0.2	1.3	0.8	-0.4	-0.1
Average weekly fortified wine intake	0.1	0.1	0.3	-0.1	-0.5	0.1	0.1	0.0	0.3	-0.6	-0.2	0.1	-0.2
Maternal smoking around birth	0.5	0.7	1.9	-1.0	-0.5	-0.5	-0.4	1.4	-0.2	-0.8	-0.7	-1.4	-1.0
Fed-up feelings	0.9	1.6	4.2	0.8	1.2	1.0	1.1	-2.1	1.2	1.1	1.3	1.2	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	2.8	1.7	1.3	1.6	1.2	-1.4	0.9	1.4	1.5	1.0	1.2
Relative age voice broke	0.3	0.5	1.5	0.9	-0.1	0.9	0.5	-1.2	-0.0	0.5	0.8	0.5	0.2
Taking other prescription medications	0.1	0.2	0.7	-0.7	0.1	-0.7	-0.8	0.3	-0.1	-0.3	-0.2	-0.4	-0.2
Age when periods started (menarche)	0.3	0.8	3.3	-1.0	-0.5	-1.0	-1.2	0.5	-1.8	-0.7	-0.5	-0.4	-0.3
Bilateral oophorectomy (both ovaries removed)	3.3	3.9	6.5	-2.5	-1.1	-2.2	-1.8	2.2	-1.5	-1.4	-1.8	-2.5	-2.0
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	2.0	-0.5	0.5	-0.6	-0.8	1.4	-0.8	0.2	0.2	-0.6	-0.7
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.7	0.8	1.3	0.7	1.2	-0.7	1.2	0.6	-0.2	1.0	0.5
Qualifications: CSEs or equivalent	0.5	0.6	1.5	1.2	-0.5	1.1	1.1	-0.7	-0.7	-0.0	0.9	-0.5	0.0
Serious illness, injury or assault to yourself	0.4	0.5	1.4	-1.2	0.1	-1.1	-1.0	0.2	-0.5	-0.4	-0.7	-0.0	-0.3
High blood pressure	0.7	1.8	5.6	-1.9	0.7	-1.8	-1.7	2.4	-0.2	-0.1	-0.2	-1.3	-1.0
Hayfever, allergic rhinitis or eczema	0.9	1.9	4.6	0.1	1.8	0.8	0.5	-1.9	1.8	0.8	0.7	2.1	1.4
Multivitamins +/- minerals	0.7	1.0	1.8	1.1	0.6	1.3	1.0	-1.1	0.9	0.7	1.3	0.9	0.7
Stomach or abdominal pain in last month	2.2	2.8	5.4	1.9	1.8	1.8	1.3	-1.4	1.4	2.3	2.0	1.2	1.2
Supplements: Glucosamine	1.7	2.2	4.1	-1.5	-1.4	-1.5	-1.4	1.3	-1.3	-1.3	-2.0	-1.3	-1.6
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.3	-0.5	0.4	0.1	0.2	-0.6	0.2	0.3	-1.1	0.7	-0.1
Medication: Atenolol	1.3	1.6	3.2	-1.2	-0.6	-1.2	-0.9	1.7	-1.2	-0.4	-1.2	-1.6	-1.8
Medication: Levothyroxine sodium	1.1	1.9	3.2	-1.3	-1.6	-1.3	-0.9	1.4	-0.6	-1.5	-1.3	-1.8	-1.6
Sitting height	0.4	2.8	8.2	1.1	2.1	0.9	0.6	-0.6	2.9	1.6	2.2	1.7	1.4
Chronic bronchitis/emphysema (father)	0.6	0.8	1.6	0.9	1.2	1.1	1.0	-1.1	0.0	1.1	0.4	0.7	0.3
High blood pressure (mother)	2.2	3.1	4.8	-2.1	-0.9	-2.2	-2.2	1.9	-1.6	-1.0	-1.2	-2.0	-2.0
Body mass index (BMI)	0.0	0.2	0.5	-0.4	0.7	-0.1	0.1	0.6	0.5	-0.3	-0.7	-0.3	0.0
Impedance of leg (left)	0.6	3.1	9.5	2.1	-0.2	1.7	1.2	-3.1	0.1	0.7	2.0	2.1	2.0
Leg predicted mass (left)	0.4	2.0	6.9	0.3	2.6	0.9	0.8	0.1	2.5	1.5	1.2	1.1	1.0
Trunk fat mass	0.5	2.0	3.3	1.0	1.8	1.3	1.0	-1.2	1.5	1.3	1.4	1.6	1.8
Waist circumference	0.5	2.0	4.8	1.0	2.2	1.4	1.4	-0.8	1.8	1.6	0.8	1.2	1.2
Number of incorrect matches in round	0.4	0.6	2.9	0.4	1.2	0.6	0.4	0.7	0.1	1.7	0.9	-0.3	-0.1
Past tobacco smoking	1.3	2.4	3.8	1.6	0.9	1.9	1.5	-1.8	1.3	1.9	1.5	1.5	1.4
Alcohol usually taken with meals	0.2	0.4	1.1	-0.8	-0.4	-0.4	-0.3	0.5	-0.1	-0.4	-1.1	-0.5	-0.9
Nervous feelings	1.6	3.0	7.0	1.7	1.1	1.3	1.2	-2.6	1.8	1.8	0.8	2.4	1.6
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.6	0.5	0.3	0.4	-0.1	-0.7	0.5	0.7	0.2	0.4	0.4
Hearing difficulty/problems with background noise	0.1	0.1	0.4	-0.3	-0.2	-0.5	-0.6	-0.2	0.3	-0.0	-0.4	0.2	0.4
Hair/balding pattern: Pattern 2	1.7	2.1	5.1	-1.2	-2.3	-1.7	-1.3	0.4	-1.9	-1.7	-1.0	-1.2	-1.2
Had menopause	0.8	1.0	2.9	-1.6	-0.2	-1.1	-0.4	1.1	-0.9	-0.1	-1.7	-1.0	-0.7
Had other major operations	0.7	0.8	2.4	0.0	1.5	0.1	-0.1	-0.7	0.5	1.2	-0.0	1.5	1.2
Forced vital capacity (FVC)	0.7	2.8	7.7	1.2	1.9	1.5	1.6	-1.0	2.8	1.8	1.7	1.5	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.7	-0.9	0.3	-0.7	-0.8	1.3	-1.3	-0.2	-0.2	-0.6	-0.7
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.7	0.8	0.7	0.6	0.8	-0.1	0.5	0.5	-0.3	0.7	0.5
Qualifications: None of the above	0.2	0.3	1.0	-0.3	-0.6	-0.3	0.0	0.7	-0.7	-0.3	-0.8	-1.0	-0.5
Financial difficulties in last 2 years	0.7	1.0	2.2	0.3	1.5	0.6	0.1	-0.8	1.0	1.3	1.3	1.1	1.0
Mouth/teeth dental problems	0.4	0.6	1.8	-1.3	-0.3	-0.6	-0.7	1.3	0.1	-0.5	0.2	-0.9	-0.7
Heart attack	2.0	2.6	3.7	-1.6	-1.1	-1.6	-1.6	1.7	-1.9	-1.4	-1.9	-1.5	-1.6
Allergy	0.3	0.6	1.7	0.5	-0.9	-0.1	0.1	1.3	-1.1	0.1	0.2	-1.3	-0.7
Pain all over the body in last month	0.8	0.9	1.4	1.0	1.2	1.2	1.2	-0.1	-0.0	1.2	1.1	0.3	0.9
Diabetes (self-reported)	0.9	1.4	3.7	1.9	0.2	1.5	1.4	-1.2	0.7	1.2	1.2	0.5	1.0
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.6	-0.7	0.1	-0.2	-0.3	-0.7	0.2	-0.3	0.1	0.8	0.3
Medication: Ramipril	0.1	0.1	0.2	-0.1	-0.3	-0.3	-0.1	0.5	-0.3	0.3	0.4	-0.4	-0.0
Medication: Simvastatin	1.7	2.5	5.5	1.0	2.2	1.2	1.1	-1.0	2.3	1.7	1.7	1.4	1.3
Fluid intelligence score	1.1	2.2	5.1	-1.7	-1.5	-1.7	-2.3	1.0	-0.8	-1.9	-0.7	-1.1	-1.4
Illnesses of siblings	4.4	6.1	9.4	2.5	2.0	2.4	2.1	-3.0	2.7	1.4	3.1	2.6	2.8
Neuroticism score	0.4	0.8	2.5	0.8	0.7	0.8	0.5	-1.1	1.6	0.9	0.6	0.9	0.3
Weight	0.7	3.4	7.2	1.1	2.7	1.6	1.3	-1.0	2.7	1.8	1.8	1.8	1.8
Impedance of arm (right)	0.2	0.8	2.3	0.2	-0.9	-0.1	-0.4	-1.5	-1.3	0.1	1.3	0.8	0.8
Arm fat percentage (right)	0.0	0.1	0.5	-0.1	0.6	0.0	-0.0	-0.4	0.2	-0.1	-0.2	0.4	0.7
Trunk fat-free mass	1.1	6.4	15.8	1.9	3.5	2.3	2.0	-0.9	4.0	2.8	2.4	2.2	1.9
Hip circumference	0.5	2.1	3.9	0.8	2.0	1.1	0.9	-1.4	1.9	1.4	1.2	1.8	1.5
Time employed in main current job	0.7	0.8	1.5	0.4	0.8	0.8	0.9	-0.3	1.2	1.1	1.2	0.8	0.9
Alcohol intake versus 10 years previously	1.6	2.3	4.5	1.6	1.5	1.2	0.8	-1.6	1.6	1.2	1.5	2.1	1.8
Father’s age at death	1.0	1.3	2.9	1.1	1.6	1.0	1.2	-0.7	1.7	1.0	-0.1	1.4	0.9
Worrier / anxious feelings	0.1	0.1	0.4	-0.2	-0.2	-0.3	-0.4	-0.5	0.6	0.5	-0.2	0.1	-0.3
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.4	6.2	2.5	1.0	2.0	1.3	-2.1	1.4	1.4	2.2	1.7	2.0
Falls in the last year	1.2	1.6	3.0	-1.7	-0.1	-1.7	-1.3	1.4	-1.0	-1.5	-1.2	-1.0	-1.1
Hair/balding pattern: Pattern 3	0.1	0.2	0.6	-0.5	-0.0	-0.7	-0.7	0.3	-0.0	-0.1	-0.8	-0.1	-0.4
Number of live births	0.1	0.1	0.3	-0.1	0.4	0.0	-0.3	-0.6	0.4	0.4	-0.2	0.2	-0.2
Forced expiratory volume in 1-second (FEV1)	1.4	4.8	10.1	1.7	2.7	2.1	2.4	-1.3	3.2	2.5	2.2	1.8	1.4
Pulse rate	0.6	1.1	2.4	1.5	0.4	1.4	0.9	-1.5	0.1	0.6	0.9	0.9	1.1
Happiness	1.6	2.0	3.7	1.4	1.8	1.4	1.0	-1.7	0.6	1.1	1.2	1.9	1.5
Noisy workplace	0.9	1.2	3.2	1.0	1.8	0.6	0.7	-0.8	0.6	1.5	0.4	1.4	1.0
Qualifications: A levels/AS levels or equivalent	0.5	1.1	1.7	-1.2	-1.0	-1.2	-1.3	0.8	-0.5	-0.9	-1.2	-0.7	-1.2
Serious illness, injury or assault of a close relative in last 2 years	3.3	3.8	5.1	-2.0	-1.9	-1.8	-2.1	1.6	-2.2	-2.2	-2.3	-1.5	-2.0
Mouth/teeth dental problems: Dentures	1.1	1.9	5.4	1.0	2.3	1.0	1.5	-0.3	2.0	1.8	0.2	1.0	1.1
Asthma	0.9	1.8	3.2	-1.6	-1.3	-1.6	-1.7	0.5	-1.6	-1.8	-1.1	-0.9	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.1	0.8	0.7	1.1	0.9	-0.7	0.3	0.7	0.0	0.7	0.4
Medication: Cholesterol lowering	0.1	0.2	0.7	0.0	0.5	-0.1	0.0	0.1	0.9	0.5	0.5	0.3	0.3
Depression (self-reported)	2.3	2.8	6.7	-1.8	-0.6	-1.9	-1.9	2.6	-1.2	-0.6	-1.5	-1.8	-1.6
Medication: Lansoprazole	0.7	0.8	1.9	1.4	1.0	0.8	0.7	-0.6	0.7	1.2	0.7	0.5	0.7
Prospective memory result	2.4	3.0	5.8	1.9	1.8	2.4	2.2	-1.0	1.3	2.0	1.5	0.8	1.5
Lung cancer (father)	0.5	0.6	2.3	-1.0	0.1	-0.9	-1.3	0.5	-1.5	0.2	-0.4	-0.2	-0.2
Illnesses of mother	4.2	5.2	6.9	2.6	1.8	2.6	2.3	-1.9	2.6	2.1	1.8	2.4	2.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.2	7.8	0.9	2.6	1.2	1.7	-0.9	2.8	2.1	1.6	1.8	1.2
Pulse wave Arterial Stiffness index	1.0	1.1	4.0	0.2	1.2	0.9	0.8	-0.8	2.0	0.8	0.6	1.4	1.0
Impedance of arm (left)	0.3	1.2	3.8	0.5	-0.8	0.3	-0.1	-1.9	-1.4	0.3	1.7	1.0	1.1
Arm fat mass (right)	0.2	0.8	2.2	0.4	1.5	0.7	0.6	-0.6	1.4	0.7	0.5	0.9	1.1
Trunk predicted mass	1.1	6.3	15.7	2.0	3.5	2.2	2.0	-0.9	4.0	2.8	2.4	2.2	1.8
Standing height	1.8	17.4	30.1	3.4	4.3	3.7	2.7	-3.5	4.8	4.6	5.5	4.6	4.0
Length of working week for main job	0.7	0.8	2.8	-0.0	1.4	0.9	0.7	-0.4	1.7	0.8	0.7	0.4	0.3
Exposure to tobacco smoke at home	0.2	0.2	1.5	0.5	0.1	0.7	1.2	0.0	-0.2	0.3	0.1	-0.0	0.1
Breastfed as a baby	0.5	0.7	1.7	-1.0	-0.3	-1.3	-1.2	0.0	-0.4	-0.8	-1.2	-0.2	-0.5
Tense / ‘highly strung’	0.2	0.2	0.8	-0.3	0.9	-0.3	-0.8	0.5	-0.2	0.4	0.3	0.1	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.1	3.4	0.6	1.8	0.5	0.5	-0.4	1.8	1.5	0.5	1.0	0.7
Hair/balding pattern: Pattern 4	0.2	0.4	0.9	0.7	0.5	0.7	0.5	0.4	1.0	0.1	0.4	0.5	0.8
Birth weight of first child	2.9	5.2	8.6	2.6	2.5	2.4	2.3	-2.0	1.8	2.9	2.0	2.1	1.8
Peak expiratory flow (PEF)	0.5	1.1	3.1	0.3	1.4	0.7	0.7	-0.1	1.8	1.2	1.5	0.6	0.5
Pulse wave reflection index	0.6	0.8	2.2	-0.1	1.2	0.4	0.6	-0.7	1.5	1.0	0.7	1.1	0.5
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.1	-1.0	-0.9	-1.0	-1.1	1.0	-0.6	-1.0	-1.3	-1.0	-1.4
Loud music exposure frequency	0.3	0.4	1.3	0.5	-0.6	0.1	0.7	-0.8	-0.4	-0.7	-1.1	0.1	0.1
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	3.8	-1.6	-1.9	-1.4	-1.6	0.5	-1.7	-1.6	-1.3	-0.8	-1.4
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	3.0	1.3	-1.0	0.5	0.6	-0.8	-1.7	-0.3	-0.2	-0.3	-0.4
Blood clot in the leg (DVT)	0.1	0.1	0.3	0.1	0.3	0.2	0.2	-0.0	0.3	0.3	-0.1	0.4	0.6
Medication: Paracetamol	0.1	0.2	0.7	0.2	0.9	0.5	0.3	-0.3	0.8	0.2	-0.4	0.5	0.3
Headache pain in last month	0.3	0.6	1.4	0.7	0.8	0.3	-0.1	-1.0	-0.3	1.2	0.9	0.7	0.8
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.8	0.8	-0.3	0.8	0.7	-0.9	-0.1	0.0	-0.3	0.4	0.2
Glaucoma (self-reported)	2.9	3.4	4.8	2.2	1.8	2.2	2.0	-1.9	0.4	1.8	2.0	1.8	1.9
Gout (self-reported)	0.3	0.4	1.6	0.6	0.7	0.1	-0.1	-0.4	0.1	0.5	1.3	0.3	0.6
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	4.5	-1.2	-1.4	-1.2	-1.0	1.6	-0.5	-1.5	-0.8	-2.1	-1.4
Medication: Amlodipine	1.3	1.8	5.2	-1.5	-0.2	-1.7	-1.5	2.3	-0.4	-0.9	-0.6	-1.5	-1.2
Medication: Ventolin 100micrograms inhaler	0.2	0.3	1.1	-0.3	0.6	0.1	-0.0	-1.0	0.4	-0.1	0.1	1.0	0.6
Birth weight	0.8	1.7	4.0	1.9	1.3	2.0	1.9	0.1	1.1	1.3	-0.1	0.7	0.0
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.0	0.4	1.1	0.4	0.6	-1.3	0.9	0.6	0.9	1.4	1.4
High blood pressure (siblings)	3.6	5.2	7.4	-2.5	-1.5	-2.3	-2.3	2.7	-2.6	-0.9	-2.5	-2.2	-2.7
Forced vital capacity (FVC), Best measure	0.7	2.4	7.1	0.7	1.9	1.0	1.4	-0.8	2.7	1.7	1.5	1.7	1.2
Body fat percentage	0.1	0.5	1.5	0.4	0.8	0.6	0.4	-1.0	0.4	0.3	0.4	1.0	1.2
Leg fat percentage (right)	0.2	0.8	1.8	0.5	1.2	0.6	0.6	-1.1	0.9	0.4	0.4	1.2	1.3
Arm fat-free mass (right)	0.8	3.9	10.4	1.5	3.0	1.8	1.6	-0.6	3.2	2.0	1.6	1.7	1.4
Exposure to tobacco smoke outside home	0.7	1.0	2.1	0.8	0.3	0.9	0.9	-1.4	1.0	0.9	1.2	0.9	1.2
Comparative body size at age 10	1.1	3.2	7.8	-1.3	-1.3	-1.1	-0.4	2.0	-1.4	-2.0	-2.8	-2.1	-2.1
Number of full brothers	0.8	1.0	3.1	-0.7	0.0	-1.2	-1.5	1.8	-0.8	-0.7	0.0	-1.0	-0.4
Worry too long after embarrassment	0.1	0.2	0.7	0.4	-0.8	0.3	-0.2	0.1	0.1	-0.2	-0.5	-0.1	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.3	0.9	1.4	0.7	0.5	-0.8	0.6	1.2	1.5	1.0	1.0
Wheeze or whistling in the chest in last year	0.2	0.3	1.8	0.2	1.4	0.2	-0.0	0.6	0.5	0.9	0.2	0.1	0.1
Number of children fathered	0.2	0.2	1.0	-0.8	-1.0	-0.2	-0.4	0.2	-0.2	-0.5	-0.5	-0.3	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	2.7	1.5	1.1	1.0	1.1	-0.3	0.6	1.6	0.9	0.4	0.5
Age at first live birth	0.3	0.5	2.1	1.1	-0.4	0.4	-0.2	-0.5	-0.6	-0.3	1.5	0.5	0.6
Pulse wave peak to peak time	0.5	0.6	2.6	-0.0	-0.9	-0.6	-0.6	0.5	-1.6	-0.5	-0.2	-1.0	-0.7
Health satisfaction	0.0	0.1	0.3	0.1	0.1	0.3	-0.1	-0.1	0.1	0.4	-0.2	0.0	0.5
Shortness of breath walking on level ground	1.9	2.2	4.1	-1.7	-1.1	-2.0	-2.0	1.5	-0.7	-1.9	-1.4	-1.2	-0.6
Qualifications: College or University degree	0.1	0.2	0.6	-0.4	0.5	-0.6	-0.8	0.3	0.2	0.4	0.0	0.1	-0.6
Eye problems/disorders: None of the above	0.5	0.6	1.8	-1.0	-0.3	-1.1	-1.3	0.6	-0.2	-0.1	-1.0	-0.4	-0.9
Mouth/teeth dental problems: Loose teeth	1.4	1.6	3.2	1.1	1.4	0.5	0.3	-1.6	0.8	1.4	1.3	1.8	1.6
Emphysema/chronic bronchitis	0.2	0.2	1.3	0.4	0.6	-0.1	-0.0	0.3	1.2	-0.1	-0.4	0.4	0.1
Medication for pain relief, constipation, heartburn	0.5	0.8	1.7	-0.8	-1.3	-1.0	-0.9	0.4	-1.2	-0.9	-0.2	-0.9	-0.8
Neck or shoulder pain in last month	0.8	1.1	2.0	1.0	1.4	0.9	0.5	-1.0	1.4	1.4	0.8	1.1	0.7
Medication: Blood pressure	0.5	0.9	2.6	-1.1	-0.2	-1.0	-1.1	1.6	-0.8	-0.3	0.3	-1.2	-0.5
Angina (self-reported)	1.3	1.7	4.9	-1.1	-1.3	-1.1	-0.8	0.5	-1.1	-1.5	-2.2	-1.3	-1.5
Migraine (self-reported)	0.5	0.6	1.1	-1.1	-0.4	-0.8	-0.9	0.4	-1.0	-0.9	-0.8	-0.7	-0.3
Medication: Ibuprofen	0.1	0.1	0.3	-0.1	0.0	0.2	0.1	-0.3	-0.6	0.3	-0.5	0.2	-0.1
Medication: Allopurinol	0.5	0.6	1.5	0.8	1.2	0.2	0.2	-0.6	0.4	0.6	1.2	1.0	1.0
Medication: Omeprazole	0.1	0.1	0.3	-0.5	-0.5	-0.1	0.0	-0.1	-0.4	-0.2	-0.1	-0.2	-0.3
Medication: Seretide 50 evohaler	0.5	0.6	1.5	-0.7	-0.7	-1.2	-1.0	-0.0	-0.4	-1.1	-0.9	-0.4	-0.2
Mean time to correctly identify matches	0.2	0.5	1.0	-0.4	0.5	-1.0	-1.0	0.9	-0.7	0.6	-0.2	-0.6	-0.4
Heart disease (mother)	4.6	5.6	7.6	-2.5	-1.8	-2.8	-2.3	1.7	-2.7	-2.0	-2.6	-2.3	-2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	0.3	-0.1	0.4	0.3	0.0	-0.1	-0.5	-0.3	-0.1	0.0
Whole body fat mass	0.3	1.3	2.5	0.7	1.6	1.0	0.8	-0.9	1.4	1.0	1.0	1.3	1.5
Leg fat mass (right)	0.4	1.5	3.4	0.8	1.9	1.0	0.8	-1.0	1.6	0.9	0.9	1.4	1.5
Arm predicted mass (right)	0.9	4.5	11.2	1.6	3.2	2.0	1.8	-0.8	3.3	2.2	1.7	1.9	1.6
Pulse rate, automated reading	2.4	7.8	11.4	3.4	2.6	3.4	2.7	-2.3	2.1	2.9	2.9	2.6	2.8
Alcohol intake frequency.	2.6	6.1	8.7	3.0	2.3	2.8	2.6	-2.6	2.4	2.3	1.7	2.4	2.6
Comparative height size at age 10	1.4	7.7	16.4	2.0	3.6	2.4	2.2	-1.6	4.0	3.1	2.5	2.9	2.3
Number of full sisters	0.4	0.5	2.6	0.6	-0.7	0.5	0.3	-0.0	-1.6	-0.3	0.4	-0.8	0.1
Suffer from ‘nerves’	2.2	3.5	6.3	2.1	1.9	1.8	1.3	-2.0	0.9	2.5	2.0	2.2	1.6
Overall health rating	0.3	0.7	1.3	1.1	0.7	1.1	0.7	-0.9	0.8	0.7	0.4	0.6	1.1
Chest pain or discomfort	0.4	0.5	1.9	0.8	0.9	0.7	0.9	-0.2	1.4	0.7	-0.2	0.5	0.3
Had major operations	0.4	0.5	1.3	1.0	0.9	0.7	0.3	-0.6	0.6	1.1	0.5	0.5	0.6
Age at last live birth	0.2	0.2	0.9	-0.1	-0.2	-0.6	-1.0	-0.3	-0.5	-0.6	0.5	-0.2	0.1
Family relationship satisfaction	0.6	0.8	2.1	0.8	1.4	0.5	0.2	-0.7	1.0	1.0	0.7	1.0	0.8
Leg pain on walking	0.8	1.0	3.6	1.0	1.0	0.5	0.2	-0.9	0.1	1.4	1.9	0.7	0.9
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	4.3	1.3	1.6	1.1	0.9	-1.0	2.1	0.8	1.1	1.6	1.3
Commuting to job workplace: Car/motor vehicle	0.2	0.2	1.2	1.1	0.1	0.5	0.4	-0.4	0.7	0.1	0.3	-0.0	0.0
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.7	-0.2	-0.8	-0.3	-0.3	0.4	0.3	-1.3	-0.7	-0.7	-0.4
Medication: Aspirin	0.2	0.2	0.6	-0.4	-0.1	-0.7	-0.2	0.8	-0.2	-0.7	-0.4	-0.4	0.0
Supplements: Vitamin C	0.5	0.6	3.5	-0.5	-0.0	-0.4	-0.2	1.9	0.0	-0.9	-0.3	-0.9	-0.5
Knee pain experienced in last month	1.4	2.1	4.7	1.1	1.9	1.4	1.1	-0.5	2.0	2.2	1.6	0.7	1.1
Hypertension (Self-reported)	1.1	3.0	8.3	-2.4	0.1	-2.2	-2.2	2.9	-0.6	-0.6	-0.2	-1.9	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.0	-1.0	-0.2	-0.8	-0.6	-0.1	0.7	-0.4	-0.6	0.1	0.1
Illnesses of father: Heart disease	1.4	1.9	5.5	-1.4	-0.5	-1.4	-1.3	2.3	-0.9	-1.0	-0.8	-1.8	-1.5
Illnesses of siblings: Diabetes	0.3	0.4	0.9	-0.3	-0.3	-0.5	-0.2	0.9	0.3	-0.4	-0.7	-0.8	-0.9
Smoking status: Previous	1.3	2.0	4.0	-1.4	-0.8	-1.7	-1.4	1.8	-0.7	-2.0	-1.6	-1.1	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.3	0.7	0.9	0.7	0.6	-0.9	1.5	0.9	1.3	1.0	1.2
Whole body fat-free mass	0.7	3.8	11.1	1.2	3.0	1.6	1.4	-0.4	3.3	2.1	1.7	1.7	1.4
Leg fat-free mass (right)	0.3	1.6	5.6	0.2	2.3	0.8	0.7	0.3	2.4	1.3	1.0	0.9	0.8
Arm fat percentage (left)	0.0	0.1	0.5	-0.1	0.5	0.1	-0.0	-0.4	0.0	-0.1	-0.2	0.3	0.7
Average weekly red wine intake	0.5	0.8	2.1	0.7	0.4	0.7	0.8	-0.9	0.8	1.0	-1.1	1.4	0.4
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.9	0.5	-0.0	0.4	0.3	-0.7	0.1	0.3	1.0	0.8	1.4
Mood swings	0.4	0.8	4.9	0.3	1.3	0.5	0.6	-0.3	2.2	0.6	0.5	0.4	0.0
Loneliness, isolation	4.2	5.7	9.2	2.7	2.4	2.8	3.0	-2.3	1.9	2.5	1.2	2.2	2.4
Long-standing illness, disability or infirmity	0.1	0.1	0.3	-0.1	-0.0	-0.2	-0.4	0.6	0.1	0.1	-0.1	-0.4	-0.4
Ever had bowel cancer screening	0.1	0.1	0.4	0.4	0.6	0.0	-0.4	0.1	0.1	0.6	0.3	-0.1	-0.3
Diabetes diagnosed by doctor	0.2	0.3	1.2	1.1	-1.1	0.6	0.3	-0.4	0.2	0.3	0.3	-0.4	0.1
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	3.6	-0.9	-1.1	-1.3	-1.0	0.5	-0.7	-1.9	-1.1	-0.9	-1.2
Friendships satisfaction	0.0	0.0	0.2	-0.4	0.4	-0.0	-0.0	-0.1	0.1	0.1	0.2	-0.2	-0.2
Qualifications: nursing, teaching	0.0	0.1	0.2	-0.0	-0.0	-0.3	-0.4	0.2	0.1	-0.1	0.0	-0.4	-0.3
Commuting to job workplace: Walk	0.3	0.3	1.4	0.1	-0.3	0.8	0.3	-0.7	0.5	-0.2	1.2	0.4	0.4
Eye problems/disorders: Cataract	2.7	3.1	5.2	-1.8	-1.9	-1.7	-1.1	1.3	-2.3	-2.1	-1.7	-1.8	-1.4
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	4.4	1.0	0.3	0.8	0.4	-2.1	0.2	0.3	0.7	1.2	1.0
Medication for cholesterol	0.4	0.6	1.3	1.1	0.3	1.0	1.0	-0.8	0.2	0.5	0.2	1.0	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.8	0.1	-0.2	0.0	-0.2	-0.1	0.1	-0.0	0.9	-0.3	0.3
Back pain experienced in last month	0.3	0.4	0.8	-0.3	-0.9	-0.1	-0.2	0.8	0.0	-0.8	-0.8	-0.6	-0.9
Mineral and other dietary supplements	0.3	0.5	1.1	1.0	0.4	0.4	0.4	-0.2	-0.7	1.0	1.1	0.3	0.5
Breast cancer (self-reported)	0.7	0.9	2.7	-1.3	0.1	-1.3	-1.5	0.3	-0.3	-0.5	-1.6	-0.1	-0.4
Asthma (self-reported)	1.1	2.2	3.8	-1.7	-1.4	-1.8	-1.9	0.7	-1.7	-1.9	-1.0	-1.1	-0.8
Osteoporosis (self-reported)	1.0	1.2	2.3	-1.5	-0.5	-1.5	-1.1	1.4	-0.9	-0.9	-0.8	-1.2	-0.7
Osteoarthritis (self-reported)	0.5	0.7	1.6	-0.8	-0.6	-0.9	-1.2	0.6	-1.1	-0.5	-1.0	-0.6	-0.7
Medication: Aspirin	0.2	0.3	0.8	-0.5	-0.1	-0.7	-0.3	0.9	0.1	-0.9	-0.2	-0.5	0.1
Medication: Gliclazide	0.4	0.5	2.6	0.3	-1.6	0.2	-0.2	0.3	-0.3	-0.9	-0.3	-0.6	-0.5
Illnesses of father: None of the above (group 1)	2.4	3.0	5.9	2.0	0.8	1.8	1.5	-2.4	1.7	1.2	1.5	1.9	1.7
Smoking status: Current	0.3	0.4	0.8	0.5	0.4	0.6	0.5	0.7	-0.5	0.9	0.6	-0.8	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	4.0	8.2	1.4	2.9	1.7	2.3	-0.9	2.7	2.3	1.4	2.0	1.5
Whole body water mass	0.7	4.0	11.7	1.2	3.2	1.6	1.4	-0.4	3.4	2.1	1.8	1.7	1.4
Leg predicted mass (right)	0.3	1.7	5.7	0.3	2.3	0.9	0.8	0.2	2.4	1.3	1.0	0.9	0.8
Arm fat mass (left)	0.1	0.3	0.9	0.1	0.9	0.4	0.3	-0.3	0.8	0.3	0.3	0.5	0.8
Number of self-reported non-cancer illnesses	0.4	0.6	1.8	-0.8	1.3	-0.9	-1.4	0.9	-0.0	0.7	-0.1	-0.2	-0.1
Average weekly champagne plus white wine intake	0.2	0.3	1.3	-0.2	0.8	0.2	-0.3	-0.0	0.9	0.6	1.1	0.1	-0.0
Miserableness	0.1	0.2	1.2	-0.1	-0.0	-0.1	-0.3	0.0	1.1	-0.5	-0.2	-0.2	-0.5
Guilty feelings	0.7	1.1	3.9	-0.8	-1.2	-0.8	-0.6	0.5	-0.4	-0.8	-2.0	-0.9	-1.4
Wears glasses or contact lenses	0.3	0.3	1.0	0.3	0.7	0.3	0.3	-0.3	1.0	1.0	-0.6	0.3	-0.2
Ever taken oral contraceptive pill	0.1	0.1	0.4	-0.2	-0.2	-0.1	-0.5	0.1	-0.1	-0.6	-0.3	0.1	-0.1
Hearing aid user	0.6	0.7	2.1	-0.4	-0.4	0.1	-0.1	-1.3	1.2	-0.6	-0.9	1.5	0.5
Mother’s age at death	0.1	0.2	0.7	0.3	0.0	0.4	0.3	-0.8	-0.3	0.2	-0.3	0.7	-0.0
Financial situation satisfaction	4.4	5.4	7.0	2.1	2.6	2.3	2.1	-2.5	1.9	2.5	1.9	2.6	2.6
Tinnitus: Yes, now most or all of the time	2.8	3.3	4.4	-1.9	-1.7	-2.0	-2.1	1.9	-1.7	-1.6	-1.5	-1.8	-1.8
Commuting to job workplace: Public transport	0.0	0.1	0.2	-0.3	0.1	0.3	0.4	-0.1	-0.2	0.2	0.2	0.1	0.2
Eye problems/disorders: Glaucoma	0.7	0.8	2.2	1.1	1.0	1.2	1.5	-0.6	-0.1	0.8	0.7	0.6	0.8
Medication: Blood pressure	0.6	1.2	2.6	-1.6	0.0	-1.6	-1.4	1.1	-0.8	-0.7	-0.7	-1.0	-1.0
Pain type(s) experienced in last month: Hip pain	0.7	0.9	3.0	0.6	1.1	0.8	0.6	-0.6	1.3	1.2	1.7	0.1	0.4
Supplements: Fish oil (including cod liver oil)	1.1	1.4	3.9	-1.8	-1.0	-0.9	-1.0	0.3	0.3	-1.7	-2.0	-0.5	-1.0
High cholesterol (Self-reported)	0.2	0.4	1.3	-0.1	1.1	-0.3	0.1	1.1	0.9	0.2	0.2	-0.5	-0.2
Medication: Bendroflumethiazide	0.2	0.3	1.7	-0.4	0.6	-0.4	-0.6	0.2	-0.5	0.3	1.3	0.0	-0.0
Medication: Paracetamol	0.4	0.6	1.4	-1.1	-0.1	-0.5	-0.6	0.7	-0.8	-0.7	-1.2	-0.5	-0.6
Medication: Lisinopril	1.0	1.2	3.3	-0.9	-0.5	-1.2	-1.1	1.8	-1.5	-0.4	0.6	-1.4	-0.7
Medication: Atorvastatin	0.0	0.0	0.2	0.0	0.0	-0.3	-0.0	-0.1	0.1	-0.1	-0.4	-0.3	-0.2
Illnesses of father: High blood pressure	4.9	6.1	9.7	-3.1	-1.7	-3.0	-2.8	2.9	-2.3	-1.9	-2.1	-2.4	-2.0
Alcohol drinker status: Never	0.5	0.6	1.7	1.3	0.3	1.2	0.9	-0.7	0.9	0.7	0.1	0.4	0.0
Ever smoked	0.5	0.9	1.9	-1.1	-0.3	-1.4	-1.0	0.8	-1.2	-0.8	-0.5	-0.9	-1.0
Basal metabolic rate	0.7	4.0	10.9	1.2	3.0	1.7	1.4	-0.6	3.3	2.0	1.9	1.8	1.6
Leg fat percentage (left)	0.2	0.9	1.6	0.7	1.1	0.9	0.8	-1.0	1.1	0.4	0.2	1.2	1.3
Arm fat-free mass (left)	0.9	4.6	13.3	1.5	3.3	1.8	1.6	-0.7	3.6	2.1	1.9	1.9	1.6
Number of operations (self-reported)	0.2	0.3	0.8	0.0	0.8	-0.4	-0.4	0.2	0.9	0.7	-0.8	0.4	0.2
Average weekly beer plus cider intake	1.1	1.7	4.3	1.3	1.8	1.4	1.2	-0.0	-0.2	1.7	2.1	0.5	0.8
Irritability	0.0	0.0	0.2	0.1	-0.1	-0.0	-0.2	-0.2	0.1	-0.5	0.2	0.3	0.2
Risk taking	1.0	1.4	3.3	-1.6	-0.3	-1.2	-0.4	1.6	-0.3	-0.6	-1.8	-1.3	-1.6
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.4	0.3	1.6	0.2	-0.1	0.1	1.1	0.6	0.8	0.6	0.7
Fractured/broken bones in last 5 years	0.2	0.2	0.7	0.2	-0.3	0.1	0.3	-0.8	-0.4	-0.4	0.5	0.4	0.7
Age started oral contraceptive pill	0.4	0.5	1.4	-1.0	-0.2	-0.5	-0.4	0.1	-1.1	-0.1	-1.2	-0.4	-0.6
Diastolic blood pressure, automated reading	0.4	1.2	2.7	0.2	1.6	0.6	0.5	-0.8	1.1	1.4	1.6	1.1	1.1
Ever depressed for a whole week	3.6	4.5	7.1	-1.7	-2.2	-2.4	-2.2	2.3	-2.7	-1.8	-1.9	-1.9	-1.8
Unable to work because of sickness or disability	4.9	6.3	8.6	2.9	2.6	2.6	2.7	-2.1	2.6	2.5	1.7	2.6	2.5
Commuting to job workplace: Cycle	0.8	1.0	2.0	-0.5	-0.7	-0.9	-0.8	1.4	-1.3	-1.3	-0.5	-1.0	-1.2
Myopia	0.1	0.2	0.6	-0.5	-0.2	-0.5	0.0	0.1	-0.4	0.4	-0.7	-0.1	-0.4
Vascular/heart problems diagnosed by doctor	0.6	1.7	4.5	1.9	-0.6	1.6	1.6	-2.1	0.3	0.2	0.3	1.2	1.1
Cholesterol lowering medication	0.2	0.3	1.7	0.2	0.9	0.3	0.5	0.2	1.3	0.1	0.5	-0.0	0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.8	-0.5	-0.1	-0.3	-0.3	0.9	-0.3	0.1	-0.1	-0.7	-0.7
Pain experienced in last month	0.4	0.7	1.4	-1.0	-1.1	-1.0	-0.6	0.3	-0.9	-1.2	-0.8	-0.6	-0.6
Supplements: Calcium	0.2	0.2	1.1	-0.1	-0.5	0.0	-0.0	0.5	0.1	-1.0	-0.6	-0.4	-0.3
Basal cell carcinoma (self-reported)	0.1	0.1	0.4	0.2	0.0	0.3	-0.0	0.2	-0.6	0.6	0.3	0.2	0.2
Heart attack/myocardial infarction (self-reported)	2.7	3.5	5.2	-1.9	-1.5	-1.9	-1.7	1.8	-2.1	-1.7	-2.3	-1.8	-1.9
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.1	-0.2	-0.1	0.0	-0.0	0.3	-0.1	-0.1	-0.2	0.0	0.2
Heart disease (siblings)	0.2	0.2	0.5	0.4	0.2	0.4	0.0	-0.4	-0.5	0.7	0.7	0.0	0.4
Alcohol drinker status: Previous	0.1	0.1	0.3	0.2	0.5	0.0	0.1	0.5	-0.5	0.5	-0.1	0.0	0.1
Pack years of smoking	1.9	2.8	5.6	-1.3	-1.5	-1.5	-1.2	2.2	-1.1	-1.3	-1.8	-2.4	-2.0
Impedance of whole body	0.4	2.2	7.5	1.4	-0.6	1.1	0.6	-2.7	-0.8	0.5	2.0	1.7	1.7
Leg fat mass (left)	0.4	1.5	3.4	0.8	1.8	1.1	0.9	-0.9	1.8	0.9	0.8	1.4	1.4
Arm predicted mass (left)	0.9	4.4	14.1	1.4	3.1	1.7	1.6	-0.7	3.8	2.0	1.6	1.8	1.6