Hub : Genes

TTC13

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.1280 0.0460 1.7e-03 0.021 NA 0.027 NA 0.037 2.4e-02 NA 1.2e-02 NA 3.8e-03
2 GTEx Colon Transverse 0.1080 0.0450 9.2e-03 0.082 NA 0.108 NA 0.099 9.6e-05 NA 8.3e-06 NA 1.9e-05
3 GTEx Skin Not Sun Exposed Suprapubic 0.1370 0.0460 1.2e-03 0.120 NA 0.070 NA 0.079 4.2e-07 NA 1.1e-04 NA 4.3e-05
4 GTEx Skin Sun Exposed Lower leg 0.1270 0.0380 1.3e-04 0.083 NA 0.070 NA 0.076 2.3e-07 NA 2.0e-06 NA 7.2e-07
5 GTEx Testis 0.3190 0.0700 7.9e-07 0.191 NA 0.204 NA 0.230 6.8e-09 NA 2.0e-09 NA 1.5e-10
6 METSIM Adipose 0.0763 0.0231 2.8e-06 0.062 0.053 0.058 0.057 0.057 1.5e-09 2.2e-08 4.9e-09 6.8e-09 5.7e-09
7 YFS Blood 0.0174 0.0085 1.3e-02 0.004 0.002 0.002 0.004 0.002 1.2e-02 5.8e-02 7.1e-02 1.8e-02 7.7e-02
8 TCGA Kidney Renal Papillary Cell Carcinoma 0.0750 0.0490 9.5e-03 0.010 0.027 0.013 NA 0.009 8.0e-02 1.0e-02 5.7e-02 NA 9.8e-02
9 TCGA Ovarian Serous Cystadenocarcinoma 0.0430 0.0260 5.6e-03 0.036 0.032 0.013 NA 0.026 1.7e-03 3.0e-03 4.2e-02 NA 6.5e-03
10 TCGA Thyroid Carcinoma 0.1160 0.0460 1.6e-09 0.079 0.099 0.080 NA 0.087 3.7e-08 7.7e-10 3.0e-08 NA 7.4e-09

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 1.3 2.0 4.0 -1.0 -1.2 -1.6 -0.8 1.6 -1.4 -1.1 -2.0 -1.5 -1.6
Bipolar Disorder or Schizophrenia 0.1 0.3 1.6 -0.5 -0.0 -0.7 -0.2 0.3 -0.6 -0.1 -1.3 -0.3 -0.6
Depressed Affect (Nagel 2018) 0.3 0.5 1.7 0.4 0.7 0.7 1.0 -1.0 1.3 0.3 -0.4 0.6 0.2
Depression (Nagel 2018) 2.1 3.1 5.9 1.5 1.6 1.9 1.5 -2.4 0.8 2.0 0.9 2.2 2.1
Intelligence (Savage-Jansen 2018) 0.3 0.9 2.8 -1.5 -0.3 -1.3 -1.7 0.3 -0.5 -0.9 -0.6 -0.2 -0.5
Neuroticism (Nagel 2018) 0.4 1.0 2.3 0.7 1.0 1.2 1.0 -1.1 1.5 1.0 -0.0 1.1 0.3
Schizophrenia (2018) 0.2 0.4 0.8 0.1 0.9 0.5 0.4 -0.8 0.3 0.8 -0.0 0.8 0.5
Schizophrenia vs Biploar Disorder 0.4 0.5 1.3 0.4 0.6 0.6 0.2 -1.1 0.5 0.5 0.4 1.0 1.0
Worry (Nagel 2018) 1.2 2.4 4.5 1.3 1.7 1.3 1.0 -2.0 1.3 2.1 1.0 2.1 1.1
Alzheimer’s Disease (in mother) 0.3 0.3 1.4 -0.1 0.1 -0.2 -0.1 1.2 -0.3 -0.6 -0.9 -0.5 -0.6
Alzheimer’s Disease (in father) 0.3 0.3 0.7 0.1 0.4 0.6 0.9 -0.2 -0.4 0.5 0.8 0.3 0.7
Alzheimer’s Disease (including proxy) 0.1 0.1 0.7 -0.1 0.6 -0.0 0.2 0.4 -0.8 -0.1 -0.2 -0.0 -0.1
Crohns Disease (2017) 0.3 0.7 2.0 -0.8 -1.4 -0.6 -1.0 0.3 -0.9 -0.9 -0.8 -0.5 -0.8
Irritable Bowel Disease (IBD) 0.4 0.8 3.0 -0.8 -1.7 -0.5 -0.6 -0.3 -1.2 -1.1 -1.0 -0.3 -0.7
Ulcerative Colitis (UC) 0.2 0.4 1.2 -0.3 -1.1 -0.1 0.2 -0.5 -1.0 -0.7 -0.7 -0.1 -0.5
Major Depression (MDD) 0.4 0.5 1.6 -0.9 -0.4 -0.9 -0.6 0.7 -0.6 -0.4 -1.3 0.1 0.5
Reaction Time 0.1 0.2 0.9 0.2 0.8 -0.1 -0.1 0.3 -0.1 0.9 0.6 0.1 0.2
Verbal and Numeric Reasoning (VNR) 0.4 0.9 2.3 -1.5 -0.8 -1.1 -1.5 0.5 0.1 -1.3 -0.8 -0.3 -0.6
Breast Cancer 0.2 0.4 1.2 -0.5 -0.5 -0.5 -0.6 1.1 -0.1 0.2 1.0 -0.9 0.1
Ovarian Cancer 3.1 4.1 5.6 2.3 1.8 1.8 1.8 -2.0 1.5 1.9 2.2 2.3 2.4
Prostate Cancer 0.1 0.1 0.6 -0.2 0.1 -0.4 -0.1 0.2 0.7 0.1 -0.4 0.1 -0.5
Age at First Birth 0.5 0.7 3.1 0.4 0.2 0.3 0.3 -1.8 -0.2 1.3 0.5 1.0 1.0
Bipolar Disorder (2011) 1.7 1.7 2.9 -1.4 -1.4 -1.4 -1.2 1.0 -1.7 -1.0 -1.6 -0.9 -1.0
Body Mass Index (BMI) (2010) 0.1 0.1 0.6 0.5 -0.1 0.4 -0.1 -0.3 -0.1 -0.4 0.8 -0.2 0.1
Coronary Artery Disease (CAD) 6.0 7.2 11.7 -3.4 -2.1 -2.6 -2.4 3.4 -2.1 -1.8 -2.2 -3.2 -3.0
Crohns Disease (2012) 0.2 0.3 0.7 -0.4 -0.8 -0.5 -0.8 0.3 -0.0 -0.7 -0.5 0.2 -0.4
Mean Putamen Volume 0.4 0.5 1.4 0.4 0.7 0.3 0.3 -1.1 0.6 0.5 1.2 0.5 0.6
Fasting Glucose 0.3 0.4 1.3 -0.5 0.1 -0.7 -0.4 1.0 0.1 -0.3 -1.1 -0.3 -0.5
HbA1C 0.3 0.4 1.6 0.0 -0.9 -0.1 -0.6 -0.5 -1.3 -0.4 -0.7 -0.1 -0.2
HDL Cholesterol 0.9 1.5 3.0 -1.6 -0.4 -1.7 -1.6 1.2 -0.7 -0.7 -1.3 -1.2 -1.2
LDL Cholesterol 0.3 0.5 1.5 -0.2 -0.4 -0.2 -0.1 1.1 0.1 -0.6 -0.8 -1.2 -1.1
Lupus 0.6 0.9 2.0 1.0 0.8 1.3 1.4 -0.2 0.7 0.4 1.3 0.4 0.9
Neuroticism (2016) 1.5 2.1 5.2 -1.8 -1.3 -1.1 -1.2 0.9 -0.4 -1.8 -2.3 -1.0 -1.8
Primary Biliary Cirrhosis 4.0 5.7 10.0 -1.9 -1.9 -2.4 -1.8 2.5 -2.3 -2.6 -3.2 -2.3 -2.8
Rheumatoid Arthritis 0.1 0.1 0.3 -0.1 0.4 0.1 0.0 -0.6 0.5 0.2 -0.3 0.4 -0.1
Schizophrenia (2014) 0.1 0.2 0.7 -0.6 -0.1 -0.6 -0.4 0.4 -0.6 0.1 -0.8 -0.1 -0.4
Triglycerides 0.7 1.2 2.6 1.5 0.4 1.6 1.0 -1.1 0.8 0.3 1.3 1.1 1.1
Type 2 Diabetes (T2D) (2012) 3.5 4.1 7.7 -1.9 -1.3 -2.0 -1.8 2.4 -2.3 -1.5 -1.5 -2.8 -2.2
Ulcerative Colitis 0.3 0.4 1.1 -0.1 -1.1 -0.0 -0.1 -1.1 -0.6 -0.4 -0.8 0.8 0.4
Blood Eosinophil Count 1.0 7.8 10.8 2.5 2.7 3.2 3.3 -2.8 2.6 2.8 2.3 2.9 2.8
Blood Platelet Count 1.0 12.1 21.0 -3.6 -3.1 -3.0 -2.0 3.6 -2.3 -3.7 -4.6 -4.0 -4.0
Blood Red Count 1.6 15.6 29.6 3.8 2.5 3.8 3.3 -5.4 0.2 4.6 3.2 5.2 4.7
Blood White Count 0.8 5.9 9.9 3.1 1.9 2.7 2.4 -2.5 2.0 2.0 2.6 2.5 2.4
Heel T-Score 0.7 5.3 8.0 2.5 1.5 2.4 2.5 -2.8 1.1 2.8 2.6 2.2 1.9
BMI 0.1 0.5 1.7 0.1 1.3 0.3 0.5 0.6 1.3 0.0 -0.4 0.3 0.7
Height 1.3 24.9 34.1 4.2 5.4 4.4 3.4 -4.2 5.8 5.8 5.6 5.5 5.0
Waist Hip Ratio (WHR) 0.7 2.9 5.7 1.8 1.9 2.4 2.3 -1.1 1.6 1.9 1.6 1.1 1.0
Systolic Blood Pressure 0.6 2.9 5.5 -2.4 -0.9 -2.3 -1.9 2.2 -0.8 -1.4 -0.3 -2.1 -1.5
Smoking Status 0.6 1.5 3.7 -1.0 -0.8 -0.9 -0.9 1.9 -1.1 -1.2 -0.6 -1.8 -1.4
Allergy or Eczema 1.1 2.9 5.6 0.6 1.9 1.3 1.3 -2.3 2.4 1.2 0.7 2.4 1.8
Cardiovascular Disease 0.4 1.3 4.8 -1.0 1.5 -0.9 -0.6 2.2 1.2 0.5 0.9 -0.9 -0.8
Hypothyroidism (self reported) 1.0 2.3 4.1 -1.6 -1.9 -1.2 -1.2 1.4 -1.3 -1.8 -0.9 -2.0 -1.4
Respiratory disease 1.1 2.4 4.4 -1.8 -1.4 -2.1 -2.1 0.2 -1.7 -2.0 -1.4 -0.7 -0.7
Type 2 Diabetes (T2D) (2018) 0.1 0.2 1.0 1.0 -0.2 0.5 0.3 -0.3 0.6 0.4 0.5 -0.3 0.1
Lung FEV1/FVC ratio 0.5 2.7 6.9 1.2 2.5 1.4 1.8 -0.7 2.1 2.6 1.2 0.5 0.4
Lung FVC 0.3 1.6 3.1 1.0 1.8 1.5 1.6 -0.9 1.3 1.5 0.7 1.3 0.8
Neuroticism 0.2 0.4 1.4 0.1 0.5 0.4 0.5 -0.8 1.2 0.5 -0.5 0.8 0.0
Chronotype (morning person) 0.8 1.9 3.3 1.2 1.7 1.4 1.2 0.2 1.6 1.8 1.7 0.9 1.1
Hair Pigment 0.0 1.1 3.9 -0.7 -1.5 -0.5 -0.5 0.1 -1.4 -1.1 -2.0 -0.3 -0.1
Tanning 0.2 2.1 6.2 -1.4 -1.0 -1.2 -1.3 2.5 -1.8 -0.7 -0.2 -1.6 -1.6
Hand grip strength (left) 0.4 1.1 2.6 1.2 1.2 1.1 0.7 -0.2 1.6 0.8 1.4 0.6 0.8
Number of treatments/medications taken 0.9 1.6 3.4 -1.7 -0.3 -1.5 -1.8 1.5 -0.8 -0.7 -1.0 -1.2 -1.1
Average weekly spirits intake 2.7 3.4 4.6 -1.9 -1.6 -1.7 -1.6 2.1 -2.1 -1.9 -1.5 -2.0 -1.9
Sensitivity / hurt feelings 0.6 1.1 2.8 -1.1 -0.9 -0.6 -0.7 1.3 0.5 -1.0 -0.9 -1.3 -1.7
Frequency of depressed mood in last 2 weeks 2.8 3.9 6.2 2.5 2.1 2.1 1.6 -1.9 1.2 2.4 1.8 2.0 1.9
Hearing difficulty/problems: Yes 0.4 0.5 1.7 0.3 0.7 0.3 0.4 -0.6 1.3 0.8 0.2 1.1 0.8
Relative age of first facial hair 0.2 0.4 1.3 1.1 -0.1 0.9 0.4 -0.4 -0.1 0.8 1.1 0.2 -0.1
Other serious medical condition/disability diagnosed by doctor 0.2 0.2 0.5 -0.1 0.7 -0.5 -0.4 0.2 -0.6 0.7 -0.2 0.6 0.2
Ever used hormone-replacement therapy (HRT) 3.2 4.1 5.5 -2.3 -1.7 -2.2 -1.9 2.3 -1.1 -1.6 -2.0 -2.3 -2.3
Ever had hysterectomy (womb removed) 2.4 2.7 3.8 -1.7 -1.0 -1.9 -1.7 1.8 -0.9 -1.4 -1.8 -1.8 -1.9
Systolic blood pressure, automated reading 1.3 3.9 6.8 -2.6 -1.4 -2.4 -2.1 1.8 -1.5 -1.8 -1.9 -2.0 -1.9
Eye problems/disorders: Diabetes related eye disease 1.4 1.5 3.2 1.5 0.7 1.4 1.3 -1.1 0.5 1.7 1.8 0.6 1.0
Angina 1.5 2.0 5.1 -1.2 -1.5 -1.2 -1.0 0.6 -1.2 -1.6 -2.3 -1.4 -1.6
Medication for hormone replacement therapy 4.2 4.7 6.9 -2.4 -1.9 -2.3 -2.6 2.5 -1.2 -2.1 -1.2 -2.4 -2.3
Vitamin and mineral supplements 0.3 0.4 1.3 -0.7 -0.3 -1.1 -1.1 0.0 -0.6 -0.2 -0.7 -0.2 -0.4
Supplements: Zinc 1.4 1.5 5.6 -0.9 -0.0 -1.2 -0.8 2.4 -0.4 -0.3 -1.7 -1.2 -1.3
Medication: Co-codamol 0.1 0.1 0.4 -0.1 -0.1 -0.0 -0.3 0.6 -0.3 -0.2 -0.3 0.1 -0.1
Medication: Metformin 1.5 2.1 4.4 -0.8 -2.1 -1.2 -1.5 1.3 -1.5 -1.2 -0.8 -2.0 -1.4
Diabetes (father) 0.6 0.7 1.4 1.0 0.2 1.0 1.2 -1.0 0.3 0.9 0.9 0.4 0.9
Diabetes (mother) 0.8 1.0 2.3 -1.3 -1.0 -1.3 -1.4 0.2 -0.8 -1.5 0.1 -0.7 -0.7
Severe depression (siblings) 0.1 0.2 0.4 -0.3 0.1 -0.5 -0.0 0.4 -0.4 0.0 -0.6 -0.6 -0.3
Pack years adult smoking proportion 1.3 2.0 4.3 -0.9 -1.4 -1.3 -1.0 1.8 -0.9 -1.2 -1.4 -2.1 -1.7
Impedance of leg (right) 0.6 2.9 8.8 1.9 0.1 1.4 1.0 -3.0 -0.0 0.8 2.2 2.0 2.0
Leg fat-free mass (left) 0.3 1.8 6.5 0.2 2.5 0.8 0.7 0.2 2.4 1.4 1.1 1.0 0.9
Trunk fat percentage 0.2 0.6 1.8 0.4 0.9 0.7 0.5 -1.0 0.4 0.4 0.6 1.1 1.3
Hand grip strength (right) 0.6 1.7 4.1 1.3 1.8 1.3 0.7 -0.3 1.6 1.0 2.0 1.1 1.1
Townsend deprivation index at recruitment 1.0 1.4 2.5 1.5 0.9 1.0 1.2 -1.3 0.5 0.9 1.6 1.1 1.4
Current tobacco smoking 0.3 0.5 1.7 1.0 0.7 0.9 0.7 0.4 -0.2 1.3 0.8 -0.4 -0.1
Average weekly fortified wine intake 0.1 0.1 0.3 -0.1 -0.5 0.1 0.1 0.0 0.3 -0.6 -0.2 0.1 -0.2
Maternal smoking around birth 0.5 0.7 1.9 -1.0 -0.5 -0.5 -0.4 1.4 -0.2 -0.8 -0.7 -1.4 -1.0
Fed-up feelings 0.9 1.6 4.2 0.8 1.2 1.0 1.1 -2.1 1.2 1.1 1.3 1.2 1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 1.4 1.8 2.8 1.7 1.3 1.6 1.2 -1.4 0.9 1.4 1.5 1.0 1.2
Relative age voice broke 0.3 0.5 1.5 0.9 -0.1 0.9 0.5 -1.2 -0.0 0.5 0.8 0.5 0.2
Taking other prescription medications 0.1 0.2 0.7 -0.7 0.1 -0.7 -0.8 0.3 -0.1 -0.3 -0.2 -0.4 -0.2
Age when periods started (menarche) 0.3 0.8 3.3 -1.0 -0.5 -1.0 -1.2 0.5 -1.8 -0.7 -0.5 -0.4 -0.3
Bilateral oophorectomy (both ovaries removed) 3.3 3.9 6.5 -2.5 -1.1 -2.2 -1.8 2.2 -1.5 -1.4 -1.8 -2.5 -2.0
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 2.0 -0.5 0.5 -0.6 -0.8 1.4 -0.8 0.2 0.2 -0.6 -0.7
Tinnitus: Yes, but not now, but have in the past 0.7 0.8 1.7 0.8 1.3 0.7 1.2 -0.7 1.2 0.6 -0.2 1.0 0.5
Qualifications: CSEs or equivalent 0.5 0.6 1.5 1.2 -0.5 1.1 1.1 -0.7 -0.7 -0.0 0.9 -0.5 0.0
Serious illness, injury or assault to yourself 0.4 0.5 1.4 -1.2 0.1 -1.1 -1.0 0.2 -0.5 -0.4 -0.7 -0.0 -0.3
High blood pressure 0.7 1.8 5.6 -1.9 0.7 -1.8 -1.7 2.4 -0.2 -0.1 -0.2 -1.3 -1.0
Hayfever, allergic rhinitis or eczema 0.9 1.9 4.6 0.1 1.8 0.8 0.5 -1.9 1.8 0.8 0.7 2.1 1.4
Multivitamins +/- minerals 0.7 1.0 1.8 1.1 0.6 1.3 1.0 -1.1 0.9 0.7 1.3 0.9 0.7
Stomach or abdominal pain in last month 2.2 2.8 5.4 1.9 1.8 1.8 1.3 -1.4 1.4 2.3 2.0 1.2 1.2
Supplements: Glucosamine 1.7 2.2 4.1 -1.5 -1.4 -1.5 -1.4 1.3 -1.3 -1.3 -2.0 -1.3 -1.6
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 1.3 -0.5 0.4 0.1 0.2 -0.6 0.2 0.3 -1.1 0.7 -0.1
Medication: Atenolol 1.3 1.6 3.2 -1.2 -0.6 -1.2 -0.9 1.7 -1.2 -0.4 -1.2 -1.6 -1.8
Medication: Levothyroxine sodium 1.1 1.9 3.2 -1.3 -1.6 -1.3 -0.9 1.4 -0.6 -1.5 -1.3 -1.8 -1.6
Sitting height 0.4 2.8 8.2 1.1 2.1 0.9 0.6 -0.6 2.9 1.6 2.2 1.7 1.4
Chronic bronchitis/emphysema (father) 0.6 0.8 1.6 0.9 1.2 1.1 1.0 -1.1 0.0 1.1 0.4 0.7 0.3
High blood pressure (mother) 2.2 3.1 4.8 -2.1 -0.9 -2.2 -2.2 1.9 -1.6 -1.0 -1.2 -2.0 -2.0
Body mass index (BMI) 0.0 0.2 0.5 -0.4 0.7 -0.1 0.1 0.6 0.5 -0.3 -0.7 -0.3 0.0
Impedance of leg (left) 0.6 3.1 9.5 2.1 -0.2 1.7 1.2 -3.1 0.1 0.7 2.0 2.1 2.0
Leg predicted mass (left) 0.4 2.0 6.9 0.3 2.6 0.9 0.8 0.1 2.5 1.5 1.2 1.1 1.0
Trunk fat mass 0.5 2.0 3.3 1.0 1.8 1.3 1.0 -1.2 1.5 1.3 1.4 1.6 1.8
Waist circumference 0.5 2.0 4.8 1.0 2.2 1.4 1.4 -0.8 1.8 1.6 0.8 1.2 1.2
Number of incorrect matches in round 0.4 0.6 2.9 0.4 1.2 0.6 0.4 0.7 0.1 1.7 0.9 -0.3 -0.1
Past tobacco smoking 1.3 2.4 3.8 1.6 0.9 1.9 1.5 -1.8 1.3 1.9 1.5 1.5 1.4
Alcohol usually taken with meals 0.2 0.4 1.1 -0.8 -0.4 -0.4 -0.3 0.5 -0.1 -0.4 -1.1 -0.5 -0.9
Nervous feelings 1.6 3.0 7.0 1.7 1.1 1.3 1.2 -2.6 1.8 1.8 0.8 2.4 1.6
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.6 0.5 0.3 0.4 -0.1 -0.7 0.5 0.7 0.2 0.4 0.4
Hearing difficulty/problems with background noise 0.1 0.1 0.4 -0.3 -0.2 -0.5 -0.6 -0.2 0.3 -0.0 -0.4 0.2 0.4
Hair/balding pattern: Pattern 2 1.7 2.1 5.1 -1.2 -2.3 -1.7 -1.3 0.4 -1.9 -1.7 -1.0 -1.2 -1.2
Had menopause 0.8 1.0 2.9 -1.6 -0.2 -1.1 -0.4 1.1 -0.9 -0.1 -1.7 -1.0 -0.7
Had other major operations 0.7 0.8 2.4 0.0 1.5 0.1 -0.1 -0.7 0.5 1.2 -0.0 1.5 1.2
Forced vital capacity (FVC) 0.7 2.8 7.7 1.2 1.9 1.5 1.6 -1.0 2.8 1.8 1.7 1.5 1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.6 1.7 -0.9 0.3 -0.7 -0.8 1.3 -1.3 -0.2 -0.2 -0.6 -0.7
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 0.7 0.8 0.7 0.6 0.8 -0.1 0.5 0.5 -0.3 0.7 0.5
Qualifications: None of the above 0.2 0.3 1.0 -0.3 -0.6 -0.3 0.0 0.7 -0.7 -0.3 -0.8 -1.0 -0.5
Financial difficulties in last 2 years 0.7 1.0 2.2 0.3 1.5 0.6 0.1 -0.8 1.0 1.3 1.3 1.1 1.0
Mouth/teeth dental problems 0.4 0.6 1.8 -1.3 -0.3 -0.6 -0.7 1.3 0.1 -0.5 0.2 -0.9 -0.7
Heart attack 2.0 2.6 3.7 -1.6 -1.1 -1.6 -1.6 1.7 -1.9 -1.4 -1.9 -1.5 -1.6
Allergy 0.3 0.6 1.7 0.5 -0.9 -0.1 0.1 1.3 -1.1 0.1 0.2 -1.3 -0.7
Pain all over the body in last month 0.8 0.9 1.4 1.0 1.2 1.2 1.2 -0.1 -0.0 1.2 1.1 0.3 0.9
Diabetes (self-reported) 0.9 1.4 3.7 1.9 0.2 1.5 1.4 -1.2 0.7 1.2 1.2 0.5 1.0
Hayfever/allergic rhinitis (self-reported) 0.1 0.2 0.6 -0.7 0.1 -0.2 -0.3 -0.7 0.2 -0.3 0.1 0.8 0.3
Medication: Ramipril 0.1 0.1 0.2 -0.1 -0.3 -0.3 -0.1 0.5 -0.3 0.3 0.4 -0.4 -0.0
Medication: Simvastatin 1.7 2.5 5.5 1.0 2.2 1.2 1.1 -1.0 2.3 1.7 1.7 1.4 1.3
Fluid intelligence score 1.1 2.2 5.1 -1.7 -1.5 -1.7 -2.3 1.0 -0.8 -1.9 -0.7 -1.1 -1.4
Illnesses of siblings 4.4 6.1 9.4 2.5 2.0 2.4 2.1 -3.0 2.7 1.4 3.1 2.6 2.8
Neuroticism score 0.4 0.8 2.5 0.8 0.7 0.8 0.5 -1.1 1.6 0.9 0.6 0.9 0.3
Weight 0.7 3.4 7.2 1.1 2.7 1.6 1.3 -1.0 2.7 1.8 1.8 1.8 1.8
Impedance of arm (right) 0.2 0.8 2.3 0.2 -0.9 -0.1 -0.4 -1.5 -1.3 0.1 1.3 0.8 0.8
Arm fat percentage (right) 0.0 0.1 0.5 -0.1 0.6 0.0 -0.0 -0.4 0.2 -0.1 -0.2 0.4 0.7
Trunk fat-free mass 1.1 6.4 15.8 1.9 3.5 2.3 2.0 -0.9 4.0 2.8 2.4 2.2 1.9
Hip circumference 0.5 2.1 3.9 0.8 2.0 1.1 0.9 -1.4 1.9 1.4 1.2 1.8 1.5
Time employed in main current job 0.7 0.8 1.5 0.4 0.8 0.8 0.9 -0.3 1.2 1.1 1.2 0.8 0.9
Alcohol intake versus 10 years previously 1.6 2.3 4.5 1.6 1.5 1.2 0.8 -1.6 1.6 1.2 1.5 2.1 1.8
Father’s age at death 1.0 1.3 2.9 1.1 1.6 1.0 1.2 -0.7 1.7 1.0 -0.1 1.4 0.9
Worrier / anxious feelings 0.1 0.1 0.4 -0.2 -0.2 -0.3 -0.4 -0.5 0.6 0.5 -0.2 0.1 -0.3
Frequency of tiredness / lethargy in last 2 weeks 2.1 3.4 6.2 2.5 1.0 2.0 1.3 -2.1 1.4 1.4 2.2 1.7 2.0
Falls in the last year 1.2 1.6 3.0 -1.7 -0.1 -1.7 -1.3 1.4 -1.0 -1.5 -1.2 -1.0 -1.1
Hair/balding pattern: Pattern 3 0.1 0.2 0.6 -0.5 -0.0 -0.7 -0.7 0.3 -0.0 -0.1 -0.8 -0.1 -0.4
Number of live births 0.1 0.1 0.3 -0.1 0.4 0.0 -0.3 -0.6 0.4 0.4 -0.2 0.2 -0.2
Forced expiratory volume in 1-second (FEV1) 1.4 4.8 10.1 1.7 2.7 2.1 2.4 -1.3 3.2 2.5 2.2 1.8 1.4
Pulse rate 0.6 1.1 2.4 1.5 0.4 1.4 0.9 -1.5 0.1 0.6 0.9 0.9 1.1
Happiness 1.6 2.0 3.7 1.4 1.8 1.4 1.0 -1.7 0.6 1.1 1.2 1.9 1.5
Noisy workplace 0.9 1.2 3.2 1.0 1.8 0.6 0.7 -0.8 0.6 1.5 0.4 1.4 1.0
Qualifications: A levels/AS levels or equivalent 0.5 1.1 1.7 -1.2 -1.0 -1.2 -1.3 0.8 -0.5 -0.9 -1.2 -0.7 -1.2
Serious illness, injury or assault of a close relative in last 2 years 3.3 3.8 5.1 -2.0 -1.9 -1.8 -2.1 1.6 -2.2 -2.2 -2.3 -1.5 -2.0
Mouth/teeth dental problems: Dentures 1.1 1.9 5.4 1.0 2.3 1.0 1.5 -0.3 2.0 1.8 0.2 1.0 1.1
Asthma 0.9 1.8 3.2 -1.6 -1.3 -1.6 -1.7 0.5 -1.6 -1.8 -1.1 -0.9 -0.7
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.1 0.8 0.7 1.1 0.9 -0.7 0.3 0.7 0.0 0.7 0.4
Medication: Cholesterol lowering 0.1 0.2 0.7 0.0 0.5 -0.1 0.0 0.1 0.9 0.5 0.5 0.3 0.3
Depression (self-reported) 2.3 2.8 6.7 -1.8 -0.6 -1.9 -1.9 2.6 -1.2 -0.6 -1.5 -1.8 -1.6
Medication: Lansoprazole 0.7 0.8 1.9 1.4 1.0 0.8 0.7 -0.6 0.7 1.2 0.7 0.5 0.7
Prospective memory result 2.4 3.0 5.8 1.9 1.8 2.4 2.2 -1.0 1.3 2.0 1.5 0.8 1.5
Lung cancer (father) 0.5 0.6 2.3 -1.0 0.1 -0.9 -1.3 0.5 -1.5 0.2 -0.4 -0.2 -0.2
Illnesses of mother 4.2 5.2 6.9 2.6 1.8 2.6 2.3 -1.9 2.6 2.1 1.8 2.4 2.5
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.2 7.8 0.9 2.6 1.2 1.7 -0.9 2.8 2.1 1.6 1.8 1.2
Pulse wave Arterial Stiffness index 1.0 1.1 4.0 0.2 1.2 0.9 0.8 -0.8 2.0 0.8 0.6 1.4 1.0
Impedance of arm (left) 0.3 1.2 3.8 0.5 -0.8 0.3 -0.1 -1.9 -1.4 0.3 1.7 1.0 1.1
Arm fat mass (right) 0.2 0.8 2.2 0.4 1.5 0.7 0.6 -0.6 1.4 0.7 0.5 0.9 1.1
Trunk predicted mass 1.1 6.3 15.7 2.0 3.5 2.2 2.0 -0.9 4.0 2.8 2.4 2.2 1.8
Standing height 1.8 17.4 30.1 3.4 4.3 3.7 2.7 -3.5 4.8 4.6 5.5 4.6 4.0
Length of working week for main job 0.7 0.8 2.8 -0.0 1.4 0.9 0.7 -0.4 1.7 0.8 0.7 0.4 0.3
Exposure to tobacco smoke at home 0.2 0.2 1.5 0.5 0.1 0.7 1.2 0.0 -0.2 0.3 0.1 -0.0 0.1
Breastfed as a baby 0.5 0.7 1.7 -1.0 -0.3 -1.3 -1.2 0.0 -0.4 -0.8 -1.2 -0.2 -0.5
Tense / ‘highly strung’ 0.2 0.2 0.8 -0.3 0.9 -0.3 -0.8 0.5 -0.2 0.4 0.3 0.1 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.1 3.4 0.6 1.8 0.5 0.5 -0.4 1.8 1.5 0.5 1.0 0.7
Hair/balding pattern: Pattern 4 0.2 0.4 0.9 0.7 0.5 0.7 0.5 0.4 1.0 0.1 0.4 0.5 0.8
Birth weight of first child 2.9 5.2 8.6 2.6 2.5 2.4 2.3 -2.0 1.8 2.9 2.0 2.1 1.8
Peak expiratory flow (PEF) 0.5 1.1 3.1 0.3 1.4 0.7 0.7 -0.1 1.8 1.2 1.5 0.6 0.5
Pulse wave reflection index 0.6 0.8 2.2 -0.1 1.2 0.4 0.6 -0.7 1.5 1.0 0.7 1.1 0.5
Ever highly irritable/argumentative for 2 days 0.9 1.1 2.1 -1.0 -0.9 -1.0 -1.1 1.0 -0.6 -1.0 -1.3 -1.0 -1.4
Loud music exposure frequency 0.3 0.4 1.3 0.5 -0.6 0.1 0.7 -0.8 -0.4 -0.7 -1.1 0.1 0.1
Qualifications: O levels/GCSEs or equivalent 1.3 2.1 3.8 -1.6 -1.9 -1.4 -1.6 0.5 -1.7 -1.6 -1.3 -0.8 -1.4
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 3.0 1.3 -1.0 0.5 0.6 -0.8 -1.7 -0.3 -0.2 -0.3 -0.4
Blood clot in the leg (DVT) 0.1 0.1 0.3 0.1 0.3 0.2 0.2 -0.0 0.3 0.3 -0.1 0.4 0.6
Medication: Paracetamol 0.1 0.2 0.7 0.2 0.9 0.5 0.3 -0.3 0.8 0.2 -0.4 0.5 0.3
Headache pain in last month 0.3 0.6 1.4 0.7 0.8 0.3 -0.1 -1.0 -0.3 1.2 0.9 0.7 0.8
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.8 0.8 -0.3 0.8 0.7 -0.9 -0.1 0.0 -0.3 0.4 0.2
Glaucoma (self-reported) 2.9 3.4 4.8 2.2 1.8 2.2 2.0 -1.9 0.4 1.8 2.0 1.8 1.9
Gout (self-reported) 0.3 0.4 1.6 0.6 0.7 0.1 -0.1 -0.4 0.1 0.5 1.3 0.3 0.6
Hypothyroidism/myxoedema (self-reported) 0.9 1.8 4.5 -1.2 -1.4 -1.2 -1.0 1.6 -0.5 -1.5 -0.8 -2.1 -1.4
Medication: Amlodipine 1.3 1.8 5.2 -1.5 -0.2 -1.7 -1.5 2.3 -0.4 -0.9 -0.6 -1.5 -1.2
Medication: Ventolin 100micrograms inhaler 0.2 0.3 1.1 -0.3 0.6 0.1 -0.0 -1.0 0.4 -0.1 0.1 1.0 0.6
Birth weight 0.8 1.7 4.0 1.9 1.3 2.0 1.9 0.1 1.1 1.3 -0.1 0.7 0.0
Chronic bronchitis/emphysema (mother) 0.8 0.9 2.0 0.4 1.1 0.4 0.6 -1.3 0.9 0.6 0.9 1.4 1.4
High blood pressure (siblings) 3.6 5.2 7.4 -2.5 -1.5 -2.3 -2.3 2.7 -2.6 -0.9 -2.5 -2.2 -2.7
Forced vital capacity (FVC), Best measure 0.7 2.4 7.1 0.7 1.9 1.0 1.4 -0.8 2.7 1.7 1.5 1.7 1.2
Body fat percentage 0.1 0.5 1.5 0.4 0.8 0.6 0.4 -1.0 0.4 0.3 0.4 1.0 1.2
Leg fat percentage (right) 0.2 0.8 1.8 0.5 1.2 0.6 0.6 -1.1 0.9 0.4 0.4 1.2 1.3
Arm fat-free mass (right) 0.8 3.9 10.4 1.5 3.0 1.8 1.6 -0.6 3.2 2.0 1.6 1.7 1.4
Exposure to tobacco smoke outside home 0.7 1.0 2.1 0.8 0.3 0.9 0.9 -1.4 1.0 0.9 1.2 0.9 1.2
Comparative body size at age 10 1.1 3.2 7.8 -1.3 -1.3 -1.1 -0.4 2.0 -1.4 -2.0 -2.8 -2.1 -2.1
Number of full brothers 0.8 1.0 3.1 -0.7 0.0 -1.2 -1.5 1.8 -0.8 -0.7 0.0 -1.0 -0.4
Worry too long after embarrassment 0.1 0.2 0.7 0.4 -0.8 0.3 -0.2 0.1 0.1 -0.2 -0.5 -0.1 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 2.3 0.9 1.4 0.7 0.5 -0.8 0.6 1.2 1.5 1.0 1.0
Wheeze or whistling in the chest in last year 0.2 0.3 1.8 0.2 1.4 0.2 -0.0 0.6 0.5 0.9 0.2 0.1 0.1
Number of children fathered 0.2 0.2 1.0 -0.8 -1.0 -0.2 -0.4 0.2 -0.2 -0.5 -0.5 -0.3 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.8 1.0 2.7 1.5 1.1 1.0 1.1 -0.3 0.6 1.6 0.9 0.4 0.5
Age at first live birth 0.3 0.5 2.1 1.1 -0.4 0.4 -0.2 -0.5 -0.6 -0.3 1.5 0.5 0.6
Pulse wave peak to peak time 0.5 0.6 2.6 -0.0 -0.9 -0.6 -0.6 0.5 -1.6 -0.5 -0.2 -1.0 -0.7
Health satisfaction 0.0 0.1 0.3 0.1 0.1 0.3 -0.1 -0.1 0.1 0.4 -0.2 0.0 0.5
Shortness of breath walking on level ground 1.9 2.2 4.1 -1.7 -1.1 -2.0 -2.0 1.5 -0.7 -1.9 -1.4 -1.2 -0.6
Qualifications: College or University degree 0.1 0.2 0.6 -0.4 0.5 -0.6 -0.8 0.3 0.2 0.4 0.0 0.1 -0.6
Eye problems/disorders: None of the above 0.5 0.6 1.8 -1.0 -0.3 -1.1 -1.3 0.6 -0.2 -0.1 -1.0 -0.4 -0.9
Mouth/teeth dental problems: Loose teeth 1.4 1.6 3.2 1.1 1.4 0.5 0.3 -1.6 0.8 1.4 1.3 1.8 1.6
Emphysema/chronic bronchitis 0.2 0.2 1.3 0.4 0.6 -0.1 -0.0 0.3 1.2 -0.1 -0.4 0.4 0.1
Medication for pain relief, constipation, heartburn 0.5 0.8 1.7 -0.8 -1.3 -1.0 -0.9 0.4 -1.2 -0.9 -0.2 -0.9 -0.8
Neck or shoulder pain in last month 0.8 1.1 2.0 1.0 1.4 0.9 0.5 -1.0 1.4 1.4 0.8 1.1 0.7
Medication: Blood pressure 0.5 0.9 2.6 -1.1 -0.2 -1.0 -1.1 1.6 -0.8 -0.3 0.3 -1.2 -0.5
Angina (self-reported) 1.3 1.7 4.9 -1.1 -1.3 -1.1 -0.8 0.5 -1.1 -1.5 -2.2 -1.3 -1.5
Migraine (self-reported) 0.5 0.6 1.1 -1.1 -0.4 -0.8 -0.9 0.4 -1.0 -0.9 -0.8 -0.7 -0.3
Medication: Ibuprofen 0.1 0.1 0.3 -0.1 0.0 0.2 0.1 -0.3 -0.6 0.3 -0.5 0.2 -0.1
Medication: Allopurinol 0.5 0.6 1.5 0.8 1.2 0.2 0.2 -0.6 0.4 0.6 1.2 1.0 1.0
Medication: Omeprazole 0.1 0.1 0.3 -0.5 -0.5 -0.1 0.0 -0.1 -0.4 -0.2 -0.1 -0.2 -0.3
Medication: Seretide 50 evohaler 0.5 0.6 1.5 -0.7 -0.7 -1.2 -1.0 -0.0 -0.4 -1.1 -0.9 -0.4 -0.2
Mean time to correctly identify matches 0.2 0.5 1.0 -0.4 0.5 -1.0 -1.0 0.9 -0.7 0.6 -0.2 -0.6 -0.4
Heart disease (mother) 4.6 5.6 7.6 -2.5 -1.8 -2.8 -2.3 1.7 -2.7 -2.0 -2.6 -2.3 -2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.2 0.3 -0.1 0.4 0.3 0.0 -0.1 -0.5 -0.3 -0.1 0.0
Whole body fat mass 0.3 1.3 2.5 0.7 1.6 1.0 0.8 -0.9 1.4 1.0 1.0 1.3 1.5
Leg fat mass (right) 0.4 1.5 3.4 0.8 1.9 1.0 0.8 -1.0 1.6 0.9 0.9 1.4 1.5
Arm predicted mass (right) 0.9 4.5 11.2 1.6 3.2 2.0 1.8 -0.8 3.3 2.2 1.7 1.9 1.6
Pulse rate, automated reading 2.4 7.8 11.4 3.4 2.6 3.4 2.7 -2.3 2.1 2.9 2.9 2.6 2.8
Alcohol intake frequency. 2.6 6.1 8.7 3.0 2.3 2.8 2.6 -2.6 2.4 2.3 1.7 2.4 2.6
Comparative height size at age 10 1.4 7.7 16.4 2.0 3.6 2.4 2.2 -1.6 4.0 3.1 2.5 2.9 2.3
Number of full sisters 0.4 0.5 2.6 0.6 -0.7 0.5 0.3 -0.0 -1.6 -0.3 0.4 -0.8 0.1
Suffer from ‘nerves’ 2.2 3.5 6.3 2.1 1.9 1.8 1.3 -2.0 0.9 2.5 2.0 2.2 1.6
Overall health rating 0.3 0.7 1.3 1.1 0.7 1.1 0.7 -0.9 0.8 0.7 0.4 0.6 1.1
Chest pain or discomfort 0.4 0.5 1.9 0.8 0.9 0.7 0.9 -0.2 1.4 0.7 -0.2 0.5 0.3
Had major operations 0.4 0.5 1.3 1.0 0.9 0.7 0.3 -0.6 0.6 1.1 0.5 0.5 0.6
Age at last live birth 0.2 0.2 0.9 -0.1 -0.2 -0.6 -1.0 -0.3 -0.5 -0.6 0.5 -0.2 0.1
Family relationship satisfaction 0.6 0.8 2.1 0.8 1.4 0.5 0.2 -0.7 1.0 1.0 0.7 1.0 0.8
Leg pain on walking 0.8 1.0 3.6 1.0 1.0 0.5 0.2 -0.9 0.1 1.4 1.9 0.7 0.9
Qualifications: NVQ or HND or HNC or equivalent 1.5 1.8 4.3 1.3 1.6 1.1 0.9 -1.0 2.1 0.8 1.1 1.6 1.3
Commuting to job workplace: Car/motor vehicle 0.2 0.2 1.2 1.1 0.1 0.5 0.4 -0.4 0.7 0.1 0.3 -0.0 0.0
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 1.7 -0.2 -0.8 -0.3 -0.3 0.4 0.3 -1.3 -0.7 -0.7 -0.4
Medication: Aspirin 0.2 0.2 0.6 -0.4 -0.1 -0.7 -0.2 0.8 -0.2 -0.7 -0.4 -0.4 0.0
Supplements: Vitamin C 0.5 0.6 3.5 -0.5 -0.0 -0.4 -0.2 1.9 0.0 -0.9 -0.3 -0.9 -0.5
Knee pain experienced in last month 1.4 2.1 4.7 1.1 1.9 1.4 1.1 -0.5 2.0 2.2 1.6 0.7 1.1
Hypertension (Self-reported) 1.1 3.0 8.3 -2.4 0.1 -2.2 -2.2 2.9 -0.6 -0.6 -0.2 -1.9 -1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 1.0 -1.0 -0.2 -0.8 -0.6 -0.1 0.7 -0.4 -0.6 0.1 0.1
Illnesses of father: Heart disease 1.4 1.9 5.5 -1.4 -0.5 -1.4 -1.3 2.3 -0.9 -1.0 -0.8 -1.8 -1.5
Illnesses of siblings: Diabetes 0.3 0.4 0.9 -0.3 -0.3 -0.5 -0.2 0.9 0.3 -0.4 -0.7 -0.8 -0.9
Smoking status: Previous 1.3 2.0 4.0 -1.4 -0.8 -1.7 -1.4 1.8 -0.7 -2.0 -1.6 -1.1 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 2.3 0.7 0.9 0.7 0.6 -0.9 1.5 0.9 1.3 1.0 1.2
Whole body fat-free mass 0.7 3.8 11.1 1.2 3.0 1.6 1.4 -0.4 3.3 2.1 1.7 1.7 1.4
Leg fat-free mass (right) 0.3 1.6 5.6 0.2 2.3 0.8 0.7 0.3 2.4 1.3 1.0 0.9 0.8
Arm fat percentage (left) 0.0 0.1 0.5 -0.1 0.5 0.1 -0.0 -0.4 0.0 -0.1 -0.2 0.3 0.7
Average weekly red wine intake 0.5 0.8 2.1 0.7 0.4 0.7 0.8 -0.9 0.8 1.0 -1.1 1.4 0.4
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.9 0.5 -0.0 0.4 0.3 -0.7 0.1 0.3 1.0 0.8 1.4
Mood swings 0.4 0.8 4.9 0.3 1.3 0.5 0.6 -0.3 2.2 0.6 0.5 0.4 0.0
Loneliness, isolation 4.2 5.7 9.2 2.7 2.4 2.8 3.0 -2.3 1.9 2.5 1.2 2.2 2.4
Long-standing illness, disability or infirmity 0.1 0.1 0.3 -0.1 -0.0 -0.2 -0.4 0.6 0.1 0.1 -0.1 -0.4 -0.4
Ever had bowel cancer screening 0.1 0.1 0.4 0.4 0.6 0.0 -0.4 0.1 0.1 0.6 0.3 -0.1 -0.3
Diabetes diagnosed by doctor 0.2 0.3 1.2 1.1 -1.1 0.6 0.3 -0.4 0.2 0.3 0.3 -0.4 0.1
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 3.6 -0.9 -1.1 -1.3 -1.0 0.5 -0.7 -1.9 -1.1 -0.9 -1.2
Friendships satisfaction 0.0 0.0 0.2 -0.4 0.4 -0.0 -0.0 -0.1 0.1 0.1 0.2 -0.2 -0.2
Qualifications: nursing, teaching 0.0 0.1 0.2 -0.0 -0.0 -0.3 -0.4 0.2 0.1 -0.1 0.0 -0.4 -0.3
Commuting to job workplace: Walk 0.3 0.3 1.4 0.1 -0.3 0.8 0.3 -0.7 0.5 -0.2 1.2 0.4 0.4
Eye problems/disorders: Cataract 2.7 3.1 5.2 -1.8 -1.9 -1.7 -1.1 1.3 -2.3 -2.1 -1.7 -1.8 -1.4
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 4.4 1.0 0.3 0.8 0.4 -2.1 0.2 0.3 0.7 1.2 1.0
Medication for cholesterol 0.4 0.6 1.3 1.1 0.3 1.0 1.0 -0.8 0.2 0.5 0.2 1.0 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.8 0.1 -0.2 0.0 -0.2 -0.1 0.1 -0.0 0.9 -0.3 0.3
Back pain experienced in last month 0.3 0.4 0.8 -0.3 -0.9 -0.1 -0.2 0.8 0.0 -0.8 -0.8 -0.6 -0.9
Mineral and other dietary supplements 0.3 0.5 1.1 1.0 0.4 0.4 0.4 -0.2 -0.7 1.0 1.1 0.3 0.5
Breast cancer (self-reported) 0.7 0.9 2.7 -1.3 0.1 -1.3 -1.5 0.3 -0.3 -0.5 -1.6 -0.1 -0.4
Asthma (self-reported) 1.1 2.2 3.8 -1.7 -1.4 -1.8 -1.9 0.7 -1.7 -1.9 -1.0 -1.1 -0.8
Osteoporosis (self-reported) 1.0 1.2 2.3 -1.5 -0.5 -1.5 -1.1 1.4 -0.9 -0.9 -0.8 -1.2 -0.7
Osteoarthritis (self-reported) 0.5 0.7 1.6 -0.8 -0.6 -0.9 -1.2 0.6 -1.1 -0.5 -1.0 -0.6 -0.7
Medication: Aspirin 0.2 0.3 0.8 -0.5 -0.1 -0.7 -0.3 0.9 0.1 -0.9 -0.2 -0.5 0.1
Medication: Gliclazide 0.4 0.5 2.6 0.3 -1.6 0.2 -0.2 0.3 -0.3 -0.9 -0.3 -0.6 -0.5
Illnesses of father: None of the above (group 1) 2.4 3.0 5.9 2.0 0.8 1.8 1.5 -2.4 1.7 1.2 1.5 1.9 1.7
Smoking status: Current 0.3 0.4 0.8 0.5 0.4 0.6 0.5 0.7 -0.5 0.9 0.6 -0.8 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.9 4.0 8.2 1.4 2.9 1.7 2.3 -0.9 2.7 2.3 1.4 2.0 1.5
Whole body water mass 0.7 4.0 11.7 1.2 3.2 1.6 1.4 -0.4 3.4 2.1 1.8 1.7 1.4
Leg predicted mass (right) 0.3 1.7 5.7 0.3 2.3 0.9 0.8 0.2 2.4 1.3 1.0 0.9 0.8
Arm fat mass (left) 0.1 0.3 0.9 0.1 0.9 0.4 0.3 -0.3 0.8 0.3 0.3 0.5 0.8
Number of self-reported non-cancer illnesses 0.4 0.6 1.8 -0.8 1.3 -0.9 -1.4 0.9 -0.0 0.7 -0.1 -0.2 -0.1
Average weekly champagne plus white wine intake 0.2 0.3 1.3 -0.2 0.8 0.2 -0.3 -0.0 0.9 0.6 1.1 0.1 -0.0
Miserableness 0.1 0.2 1.2 -0.1 -0.0 -0.1 -0.3 0.0 1.1 -0.5 -0.2 -0.2 -0.5
Guilty feelings 0.7 1.1 3.9 -0.8 -1.2 -0.8 -0.6 0.5 -0.4 -0.8 -2.0 -0.9 -1.4
Wears glasses or contact lenses 0.3 0.3 1.0 0.3 0.7 0.3 0.3 -0.3 1.0 1.0 -0.6 0.3 -0.2
Ever taken oral contraceptive pill 0.1 0.1 0.4 -0.2 -0.2 -0.1 -0.5 0.1 -0.1 -0.6 -0.3 0.1 -0.1
Hearing aid user 0.6 0.7 2.1 -0.4 -0.4 0.1 -0.1 -1.3 1.2 -0.6 -0.9 1.5 0.5
Mother’s age at death 0.1 0.2 0.7 0.3 0.0 0.4 0.3 -0.8 -0.3 0.2 -0.3 0.7 -0.0
Financial situation satisfaction 4.4 5.4 7.0 2.1 2.6 2.3 2.1 -2.5 1.9 2.5 1.9 2.6 2.6
Tinnitus: Yes, now most or all of the time 2.8 3.3 4.4 -1.9 -1.7 -2.0 -2.1 1.9 -1.7 -1.6 -1.5 -1.8 -1.8
Commuting to job workplace: Public transport 0.0 0.1 0.2 -0.3 0.1 0.3 0.4 -0.1 -0.2 0.2 0.2 0.1 0.2
Eye problems/disorders: Glaucoma 0.7 0.8 2.2 1.1 1.0 1.2 1.5 -0.6 -0.1 0.8 0.7 0.6 0.8
Medication: Blood pressure 0.6 1.2 2.6 -1.6 0.0 -1.6 -1.4 1.1 -0.8 -0.7 -0.7 -1.0 -1.0
Pain type(s) experienced in last month: Hip pain 0.7 0.9 3.0 0.6 1.1 0.8 0.6 -0.6 1.3 1.2 1.7 0.1 0.4
Supplements: Fish oil (including cod liver oil) 1.1 1.4 3.9 -1.8 -1.0 -0.9 -1.0 0.3 0.3 -1.7 -2.0 -0.5 -1.0
High cholesterol (Self-reported) 0.2 0.4 1.3 -0.1 1.1 -0.3 0.1 1.1 0.9 0.2 0.2 -0.5 -0.2
Medication: Bendroflumethiazide 0.2 0.3 1.7 -0.4 0.6 -0.4 -0.6 0.2 -0.5 0.3 1.3 0.0 -0.0
Medication: Paracetamol 0.4 0.6 1.4 -1.1 -0.1 -0.5 -0.6 0.7 -0.8 -0.7 -1.2 -0.5 -0.6
Medication: Lisinopril 1.0 1.2 3.3 -0.9 -0.5 -1.2 -1.1 1.8 -1.5 -0.4 0.6 -1.4 -0.7
Medication: Atorvastatin 0.0 0.0 0.2 0.0 0.0 -0.3 -0.0 -0.1 0.1 -0.1 -0.4 -0.3 -0.2
Illnesses of father: High blood pressure 4.9 6.1 9.7 -3.1 -1.7 -3.0 -2.8 2.9 -2.3 -1.9 -2.1 -2.4 -2.0
Alcohol drinker status: Never 0.5 0.6 1.7 1.3 0.3 1.2 0.9 -0.7 0.9 0.7 0.1 0.4 0.0
Ever smoked 0.5 0.9 1.9 -1.1 -0.3 -1.4 -1.0 0.8 -1.2 -0.8 -0.5 -0.9 -1.0
Basal metabolic rate 0.7 4.0 10.9 1.2 3.0 1.7 1.4 -0.6 3.3 2.0 1.9 1.8 1.6
Leg fat percentage (left) 0.2 0.9 1.6 0.7 1.1 0.9 0.8 -1.0 1.1 0.4 0.2 1.2 1.3
Arm fat-free mass (left) 0.9 4.6 13.3 1.5 3.3 1.8 1.6 -0.7 3.6 2.1 1.9 1.9 1.6
Number of operations (self-reported) 0.2 0.3 0.8 0.0 0.8 -0.4 -0.4 0.2 0.9 0.7 -0.8 0.4 0.2
Average weekly beer plus cider intake 1.1 1.7 4.3 1.3 1.8 1.4 1.2 -0.0 -0.2 1.7 2.1 0.5 0.8
Irritability 0.0 0.0 0.2 0.1 -0.1 -0.0 -0.2 -0.2 0.1 -0.5 0.2 0.3 0.2
Risk taking 1.0 1.4 3.3 -1.6 -0.3 -1.2 -0.4 1.6 -0.3 -0.6 -1.8 -1.3 -1.6
Ever had prostate specific antigen (PSA) test 0.5 0.6 2.4 0.3 1.6 0.2 -0.1 0.1 1.1 0.6 0.8 0.6 0.7
Fractured/broken bones in last 5 years 0.2 0.2 0.7 0.2 -0.3 0.1 0.3 -0.8 -0.4 -0.4 0.5 0.4 0.7
Age started oral contraceptive pill 0.4 0.5 1.4 -1.0 -0.2 -0.5 -0.4 0.1 -1.1 -0.1 -1.2 -0.4 -0.6
Diastolic blood pressure, automated reading 0.4 1.2 2.7 0.2 1.6 0.6 0.5 -0.8 1.1 1.4 1.6 1.1 1.1
Ever depressed for a whole week 3.6 4.5 7.1 -1.7 -2.2 -2.4 -2.2 2.3 -2.7 -1.8 -1.9 -1.9 -1.8
Unable to work because of sickness or disability 4.9 6.3 8.6 2.9 2.6 2.6 2.7 -2.1 2.6 2.5 1.7 2.6 2.5
Commuting to job workplace: Cycle 0.8 1.0 2.0 -0.5 -0.7 -0.9 -0.8 1.4 -1.3 -1.3 -0.5 -1.0 -1.2
Myopia 0.1 0.2 0.6 -0.5 -0.2 -0.5 0.0 0.1 -0.4 0.4 -0.7 -0.1 -0.4
Vascular/heart problems diagnosed by doctor 0.6 1.7 4.5 1.9 -0.6 1.6 1.6 -2.1 0.3 0.2 0.3 1.2 1.1
Cholesterol lowering medication 0.2 0.3 1.7 0.2 0.9 0.3 0.5 0.2 1.3 0.1 0.5 -0.0 0.3
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.8 -0.5 -0.1 -0.3 -0.3 0.9 -0.3 0.1 -0.1 -0.7 -0.7
Pain experienced in last month 0.4 0.7 1.4 -1.0 -1.1 -1.0 -0.6 0.3 -0.9 -1.2 -0.8 -0.6 -0.6
Supplements: Calcium 0.2 0.2 1.1 -0.1 -0.5 0.0 -0.0 0.5 0.1 -1.0 -0.6 -0.4 -0.3
Basal cell carcinoma (self-reported) 0.1 0.1 0.4 0.2 0.0 0.3 -0.0 0.2 -0.6 0.6 0.3 0.2 0.2
Heart attack/myocardial infarction (self-reported) 2.7 3.5 5.2 -1.9 -1.5 -1.9 -1.7 1.8 -2.1 -1.7 -2.3 -1.8 -1.9
Deep venous thrombosis (DVT) (self-reported) 0.0 0.0 0.1 -0.2 -0.1 0.0 -0.0 0.3 -0.1 -0.1 -0.2 0.0 0.2
Heart disease (siblings) 0.2 0.2 0.5 0.4 0.2 0.4 0.0 -0.4 -0.5 0.7 0.7 0.0 0.4
Alcohol drinker status: Previous 0.1 0.1 0.3 0.2 0.5 0.0 0.1 0.5 -0.5 0.5 -0.1 0.0 0.1
Pack years of smoking 1.9 2.8 5.6 -1.3 -1.5 -1.5 -1.2 2.2 -1.1 -1.3 -1.8 -2.4 -2.0
Impedance of whole body 0.4 2.2 7.5 1.4 -0.6 1.1 0.6 -2.7 -0.8 0.5 2.0 1.7 1.7
Leg fat mass (left) 0.4 1.5 3.4 0.8 1.8 1.1 0.9 -0.9 1.8 0.9 0.8 1.4 1.4
Arm predicted mass (left) 0.9 4.4 14.1 1.4 3.1 1.7 1.6 -0.7 3.8 2.0 1.6 1.8 1.6