Hub : Genes

EGLN1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0780 0.0220 1.9e-09 0.095 0.075 0.071 0.08 0.082 1.1e-11 1.7e-09 4.7e-09 5.6e-10 3.5e-10
2 GTEx Muscle Skeletal 0.0894 0.0357 2.2e-03 0.071 NA 0.042 NA 0.047 1.6e-07 NA 5.2e-05 NA 1.9e-05
3 NTR Blood 0.0199 0.0080 6.4e-04 0.019 0.006 0.010 0.01 0.012 6.6e-07 3.7e-03 3.3e-04 1.8e-04 7.3e-05
4 TCGA Kidney Renal Clear Cell Carcinoma 0.0398 0.0219 5.8e-05 0.040 0.034 0.022 NA 0.030 2.2e-05 8.9e-05 1.5e-03 NA 2.3e-04
5 TCGA Kidney Renal Papillary Cell Carcinoma 0.0720 0.0480 2.9e-03 0.024 0.037 0.031 NA 0.026 1.6e-02 3.5e-03 6.4e-03 NA 1.2e-02
6 TCGA Prostate Adenocarcinoma 0.0230 0.0178 6.0e-03 0.020 0.006 0.007 NA 0.013 2.9e-03 6.2e-02 5.5e-02 NA 1.4e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 1.2 1.9 4.7 -0.1 -2.2 -2.1 -1.0 -1.0 0.3
Bipolar Disorder or Schizophrenia 0.9 2.2 5.1 2.3 -0.3 -0.4 1.3 -2.0 -1.5
Depressed Affect (Nagel 2018) 3.0 6.2 10.9 -2.1 -1.5 -1.9 -2.8 3.0 3.3
Depression (Nagel 2018) 0.9 1.4 2.9 0.4 -1.6 -1.7 -1.1 0.3 1.1
Intelligence (Savage-Jansen 2018) 0.1 0.3 0.8 -0.0 -0.2 -0.2 -0.7 0.8 0.9
Neuroticism (Nagel 2018) 2.2 5.2 9.7 -1.5 -1.3 -1.8 -2.3 3.1 3.1
Schizophrenia (2018) 2.1 4.5 9.2 3.0 1.4 1.2 2.6 -1.8 -2.1
Schizophrenia vs Biploar Disorder 1.5 2.0 4.8 0.3 2.2 2.2 1.3 0.4 -0.6
Worry (Nagel 2018) 0.4 0.9 2.5 0.1 0.1 -0.3 -0.6 1.6 1.5
Alzheimer’s Disease (in mother) 1.3 1.5 1.7 1.3 1.2 1.3 1.3 -0.9 -1.2
Alzheimer’s Disease (in father) 1.1 1.2 2.2 0.6 0.7 0.8 1.3 -1.5 -1.5
Alzheimer’s Disease (including proxy) 0.9 1.2 2.5 1.0 0.5 0.7 1.1 -1.6 -1.4
Crohns Disease (2017) 0.7 1.6 2.6 1.5 1.5 1.5 1.6 0.2 -0.6
Irritable Bowel Disease (IBD) 0.3 0.8 1.6 1.2 0.8 0.8 1.1 -0.3 -0.7
Ulcerative Colitis (UC) 0.1 0.1 0.4 0.7 -0.1 -0.3 0.1 -0.3 -0.2
Major Depression (MDD) 0.6 0.8 1.5 -0.6 -1.2 -1.1 -1.1 0.2 0.6
Reaction Time 0.3 0.6 2.0 0.4 -0.3 -0.2 0.5 -1.4 -1.0
Verbal and Numeric Reasoning (VNR) 0.2 0.4 0.7 -0.5 0.7 0.7 0.0 0.9 0.5
Breast Cancer 3.5 8.4 13.2 -3.6 -2.5 -2.7 -3.5 2.0 2.8
Ovarian Cancer 1.7 2.2 5.1 2.3 1.0 1.1 1.7 -1.1 -1.3
Prostate Cancer 0.6 0.9 1.8 0.2 1.3 1.4 0.7 1.0 0.2
Age at First Birth 0.8 1.2 2.0 1.2 1.1 1.2 1.4 -0.6 -1.0
Bipolar Disorder (2011) 1.1 1.1 2.7 0.3 -1.6 -1.5 -0.6 -1.1 -0.1
Body Mass Index (BMI) (2010) 0.1 0.2 0.4 0.3 0.5 0.6 0.5 -0.1 -0.4
Coronary Artery Disease (CAD) 0.7 0.8 1.7 -0.3 0.6 0.8 0.9 -1.3 -1.2
Crohns Disease (2012) 1.0 1.6 2.7 1.4 1.2 1.4 1.6 -0.7 -1.1
Mean Putamen Volume 0.5 0.5 2.0 -1.4 0.1 0.0 -0.6 0.7 0.6
Fasting Glucose 0.1 0.1 0.1 -0.2 -0.2 -0.3 0.2 0.4 -0.0
HbA1C 2.9 3.2 6.6 1.7 -0.9 -1.0 2.2 -1.8 -2.6
HDL Cholesterol 0.4 0.7 1.8 0.5 1.3 1.2 0.9 0.2 -0.4
LDL Cholesterol 0.8 1.3 2.9 0.9 1.6 1.7 1.1 0.4 -0.3
Lupus 0.3 0.4 1.6 1.3 0.3 0.2 0.7 -0.4 -0.4
Neuroticism (2016) 1.1 1.6 2.1 -1.2 -1.2 -1.3 -1.3 0.9 1.5
Primary Biliary Cirrhosis 0.2 0.3 1.7 1.3 0.2 0.1 0.4 0.3 0.2
Rheumatoid Arthritis 0.2 0.3 0.5 0.7 0.5 0.4 0.6 -0.3 -0.5
Schizophrenia (2014) 0.9 1.9 3.2 1.8 0.6 0.6 1.6 -1.6 -1.6
Triglycerides 0.9 1.4 2.0 -1.4 -0.8 -0.9 -1.4 1.3 1.3
Type 2 Diabetes (T2D) (2012) 0.1 0.2 0.3 -0.5 0.5 0.5 0.1 0.3 0.3
Ulcerative Colitis 0.2 0.3 0.7 0.4 0.1 0.1 0.7 -0.9 -0.8
Blood Eosinophil Count 0.1 1.0 1.8 -1.3 -0.6 -0.8 -1.0 0.9 1.1
Blood Platelet Count 0.2 2.3 5.5 -2.3 -0.5 -0.7 -1.6 1.5 1.6
Blood Red Count 6.3 60.6 161.3 2.4 1.8 3.2 7.3 -12.7 -11.4
Blood White Count 0.2 1.1 2.3 -0.6 -1.4 -1.5 -1.2 0.2 0.9
Heel T-Score 0.3 2.4 4.2 -0.8 -2.0 -2.0 -1.5 0.8 1.6
BMI 0.1 0.6 2.0 -1.4 0.2 -0.3 -0.3 0.9 0.7
Height 0.4 7.7 15.8 0.8 4.0 3.7 1.6 3.5 1.3
Waist Hip Ratio (WHR) 0.1 0.4 1.0 -0.2 -0.7 -0.5 0.3 -1.0 -0.6
Systolic Blood Pressure 0.2 1.2 2.0 0.4 1.2 1.1 1.4 -0.7 -1.3
Smoking Status 0.3 0.7 0.9 -0.8 -0.8 -0.9 -0.9 0.6 0.9
Allergy or Eczema 0.5 1.3 3.3 -0.6 -0.1 -0.3 -1.1 1.8 1.7
Cardiovascular Disease 0.8 2.7 6.4 -2.0 0.1 -0.3 -1.2 2.5 2.1
Hypothyroidism (self reported) 0.3 0.7 2.2 0.2 0.7 0.4 -0.1 1.5 1.0
Respiratory disease 0.8 1.8 2.8 1.0 1.0 1.2 1.5 -1.7 -1.6
Type 2 Diabetes (T2D) (2018) 0.4 0.7 1.7 0.4 1.3 1.0 1.1 0.1 -0.6
Lung FEV1/FVC ratio 0.5 2.8 5.3 0.5 2.2 2.3 1.9 -0.6 -1.6
Lung FVC 0.1 0.3 0.4 0.3 -0.5 -0.5 -0.6 0.5 0.5
Neuroticism 1.9 4.5 7.7 -1.6 -1.4 -1.7 -2.3 2.5 2.8
Chronotype (morning person) 0.1 0.3 0.9 0.2 0.5 0.3 0.0 1.0 0.5
Hair Pigment 0.2 6.3 15.8 -0.6 -4.0 -3.7 -2.4 -1.3 0.7
Tanning 0.1 1.5 5.0 0.4 -0.9 -0.7 0.4 -2.2 -1.6
Hand grip strength (left) 3.4 9.0 13.0 3.1 3.5 3.5 3.6 -1.0 -2.4
Number of treatments/medications taken 0.9 1.5 5.4 -0.1 0.6 0.0 -0.5 2.3 1.8
Average weekly spirits intake 1.2 1.4 3.3 1.8 0.5 0.4 1.4 -1.2 -1.3
Sensitivity / hurt feelings 1.4 2.4 4.3 -1.2 -1.0 -1.3 -1.6 1.9 2.1
Frequency of depressed mood in last 2 weeks 0.3 0.5 0.8 -0.2 -0.7 -0.8 -0.8 0.5 0.9
Hearing difficulty/problems: Yes 0.2 0.3 0.9 -0.1 0.9 0.9 0.2 0.6 0.1
Relative age of first facial hair 1.4 2.9 4.6 2.1 1.5 1.6 1.8 -1.3 -1.8
Other serious medical condition/disability diagnosed by doctor 0.4 0.6 1.8 -0.1 -0.0 0.1 0.6 -1.4 -1.1
Ever used hormone-replacement therapy (HRT) 1.8 2.3 3.8 -1.9 -1.6 -1.9 -1.6 0.6 1.2
Ever had hysterectomy (womb removed) 0.5 0.6 2.2 -1.5 -0.2 -0.2 -0.7 0.6 0.5
Systolic blood pressure, automated reading 0.9 2.7 4.4 1.2 2.1 1.9 2.0 -0.7 -1.5
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 2.2 1.5 0.7 0.7 0.9 -0.4 -0.7
Angina 0.3 0.4 2.0 1.4 -0.1 -0.1 0.3 -0.2 -0.1
Medication for hormone replacement therapy 0.5 0.5 1.1 -0.3 -1.1 -1.0 -0.8 -0.2 0.3
Vitamin and mineral supplements 0.8 1.1 2.3 0.3 1.4 1.5 1.1 -0.3 -1.0
Supplements: Zinc 0.7 0.7 2.7 1.6 -0.4 -0.3 0.5 -0.9 -0.6
Medication: Co-codamol 1.0 1.1 3.1 1.8 1.1 1.0 1.1 0.1 -0.2
Medication: Metformin 1.2 1.7 2.2 1.2 1.4 1.3 1.5 -0.9 -1.5
Diabetes (father) 1.0 1.2 4.4 -2.1 -0.1 0.0 -0.9 1.1 0.9
Diabetes (mother) 0.5 0.7 1.7 -0.6 -0.1 -0.3 -0.6 1.3 1.2
Severe depression (siblings) 0.2 0.2 0.5 0.7 0.3 0.4 0.4 -0.3 -0.4
Pack years adult smoking proportion 0.4 0.6 2.1 -1.5 0.8 0.7 -0.0 0.7 0.3
Impedance of leg (right) 0.4 2.0 5.5 1.5 -1.2 -0.8 0.5 -2.4 -1.4
Leg fat-free mass (left) 1.0 5.2 13.5 -2.7 1.7 1.1 -0.9 3.7 2.4
Trunk fat percentage 0.2 0.9 2.3 -0.1 1.5 1.2 1.1 0.2 -0.4
Hand grip strength (right) 1.5 4.1 6.2 1.8 2.5 2.5 2.5 -0.6 -1.6
Townsend deprivation index at recruitment 0.6 0.9 2.1 1.0 -0.9 -0.8 0.1 -1.4 -0.7
Current tobacco smoking 0.1 0.1 0.4 0.1 -0.6 -0.6 -0.2 -0.0 0.2
Average weekly fortified wine intake 0.2 0.2 0.7 -0.4 0.1 -0.1 -0.4 0.8 0.7
Maternal smoking around birth 2.6 3.8 5.2 -1.8 -2.2 -2.3 -2.3 1.0 1.9
Fed-up feelings 3.0 5.5 9.1 -2.0 -1.5 -1.9 -2.6 2.6 3.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 2.0 -0.5 -1.4 -1.4 -1.1 0.4 1.0
Relative age voice broke 0.8 1.2 2.3 1.5 0.1 0.3 0.9 -1.5 -1.4
Taking other prescription medications 1.2 1.8 6.2 -0.6 0.6 0.2 -0.6 2.5 1.8
Age when periods started (menarche) 1.0 2.4 5.9 1.9 -0.3 0.1 1.1 -2.4 -1.9
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 2.0 -1.4 -0.1 -0.1 -0.2 -0.1 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 1.1 -0.3 -1.1 -1.0 -0.8 0.2 0.5
Tinnitus: Yes, but not now, but have in the past 6.6 7.0 9.7 -3.0 -1.7 -2.0 -2.9 2.8 3.1
Qualifications: CSEs or equivalent 9.6 12.7 18.6 -2.2 -4.2 -4.3 -4.2 2.0 3.7
Serious illness, injury or assault to yourself 0.1 0.1 0.2 -0.4 0.0 -0.0 -0.2 0.3 0.3
High blood pressure 0.5 1.3 4.2 -0.9 0.6 0.1 -0.5 2.1 1.4
Hayfever, allergic rhinitis or eczema 0.9 2.0 4.0 -0.8 -0.7 -0.8 -1.5 1.9 2.0
Multivitamins +/- minerals 1.0 1.2 2.3 -0.9 -1.5 -1.5 -1.2 0.2 0.8
Stomach or abdominal pain in last month 0.2 0.2 0.4 -0.6 -0.3 -0.3 -0.6 0.4 0.5
Supplements: Glucosamine 1.2 1.5 2.7 1.6 0.4 0.6 1.2 -1.6 -1.5
Diverticular disease/diverticulitis (self-reported) 1.9 2.3 5.2 -0.9 -2.2 -2.3 -1.6 -0.4 0.5
Medication: Atenolol 0.1 0.1 0.8 -0.9 0.1 -0.2 -0.1 0.2 0.1
Medication: Levothyroxine sodium 1.3 2.2 5.2 0.7 2.3 2.0 1.1 1.6 0.4
Sitting height 1.2 8.5 26.8 -1.7 2.2 1.7 -1.1 5.2 3.5
Chronic bronchitis/emphysema (father) 1.7 2.0 3.7 1.9 0.9 0.9 1.6 -1.4 -1.5
High blood pressure (mother) 0.1 0.2 0.3 -0.4 0.5 0.6 0.0 0.5 0.3
Body mass index (BMI) 0.2 0.9 2.0 -1.4 0.9 0.4 -0.2 1.4 0.8
Impedance of leg (left) 0.4 2.0 4.9 1.5 -1.5 -1.0 0.3 -2.2 -1.2
Leg predicted mass (left) 1.0 5.1 13.1 -2.6 1.6 1.1 -0.9 3.6 2.4
Trunk fat mass 0.3 1.3 2.7 -1.0 1.6 1.2 0.5 1.4 0.5
Waist circumference 0.2 0.8 1.5 -1.1 1.2 0.9 0.4 1.0 0.3
Number of incorrect matches in round 0.5 0.8 1.9 0.3 -1.2 -1.4 -0.7 0.3 0.7
Past tobacco smoking 0.2 0.3 0.7 0.0 0.8 0.8 0.5 -0.1 -0.5
Alcohol usually taken with meals 0.3 0.5 1.3 -0.3 1.1 1.0 0.5 0.3 -0.2
Nervous feelings 0.7 1.4 2.4 1.3 1.5 1.2 0.6 1.3 0.6
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 3.6 -1.9 -0.6 -0.6 -1.0 0.6 0.8
Hearing difficulty/problems with background noise 0.2 0.3 0.8 0.6 0.9 0.7 0.5 0.4 0.0
Hair/balding pattern: Pattern 2 0.3 0.4 0.7 0.7 0.8 0.7 0.7 0.1 -0.3
Had menopause 0.3 0.4 1.5 -0.3 -0.1 0.1 0.2 -1.2 -1.0
Had other major operations 0.2 0.3 0.5 -0.2 -0.7 -0.7 -0.5 0.2 0.5
Forced vital capacity (FVC) 0.8 3.0 8.0 -1.5 0.1 -0.1 -1.4 2.8 2.3
Heel bone mineral density (BMD) T-score, automated (right) 0.0 0.1 0.3 -0.5 -0.3 -0.3 -0.2 0.1 0.1
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.2 -0.4 -0.1 -0.3 -0.3 0.2 0.3
Qualifications: None of the above 0.1 0.3 0.6 0.6 -0.3 -0.5 -0.5 0.6 0.8
Financial difficulties in last 2 years 1.1 1.4 2.1 -1.2 -1.4 -1.3 -1.4 0.6 1.1
Mouth/teeth dental problems 2.4 3.6 6.0 -0.0 1.9 2.2 2.1 -1.8 -2.4
Heart attack 0.4 0.6 1.4 1.2 0.9 0.8 0.6 0.4 0.1
Allergy 0.2 0.5 1.2 0.1 0.1 0.2 0.6 -1.1 -1.1
Pain all over the body in last month 0.4 0.4 1.2 1.1 -0.2 -0.2 0.3 -1.0 -0.6
Diabetes (self-reported) 1.0 1.5 2.7 1.5 1.6 1.4 1.4 0.2 -0.6
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 1.6 -1.3 -0.9 -0.8 -0.5 -0.6 -0.2
Medication: Ramipril 0.1 0.1 0.7 -0.9 0.1 0.0 -0.0 0.1 -0.1
Medication: Simvastatin 0.1 0.1 0.3 -0.1 -0.1 -0.3 -0.4 0.5 0.5
Fluid intelligence score 0.3 0.6 1.5 -0.0 1.2 1.2 0.6 0.3 -0.2
Illnesses of siblings 0.1 0.1 0.2 0.4 0.1 0.2 -0.2 0.4 0.3
Neuroticism score 3.0 6.3 12.6 -1.8 -1.0 -1.4 -2.6 3.5 3.5
Weight 0.7 3.4 8.9 -1.8 1.8 1.3 -0.2 3.0 1.8
Impedance of arm (right) 1.2 5.5 10.0 3.2 1.2 1.6 2.4 -2.4 -2.6
Arm fat percentage (right) 0.4 1.7 4.5 0.2 2.1 1.8 1.4 0.3 -0.7
Trunk fat-free mass 1.2 6.6 18.2 -2.7 1.3 0.9 -1.4 4.3 3.1
Hip circumference 0.4 1.7 4.0 -0.9 1.6 1.2 0.1 2.0 1.1
Time employed in main current job 0.9 1.0 1.8 -0.8 -0.9 -1.3 -1.2 0.6 1.0
Alcohol intake versus 10 years previously 0.1 0.2 0.4 0.2 0.4 0.5 0.6 -0.4 -0.5
Father’s age at death 2.2 2.9 5.0 1.1 1.3 1.6 1.8 -1.9 -2.2
Worrier / anxious feelings 0.2 0.4 0.8 -0.1 0.8 0.7 0.2 0.9 0.5
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.9 2.7 -1.1 -1.2 -1.4 -1.6 1.2 1.6
Falls in the last year 0.4 0.6 1.4 0.0 -1.1 -1.2 -0.8 -0.5 0.1
Hair/balding pattern: Pattern 3 1.0 1.4 2.9 -0.8 -0.7 -0.9 -1.1 1.5 1.7
Number of live births 0.1 0.2 0.5 -0.0 0.7 0.5 0.4 0.2 -0.0
Forced expiratory volume in 1-second (FEV1) 0.7 2.4 6.2 -1.7 0.1 0.0 -1.3 2.5 2.0
Pulse rate 1.7 2.8 4.6 1.8 0.8 1.0 1.7 -2.1 -2.2
Happiness 0.9 1.1 2.2 -0.1 -0.9 -0.9 -1.1 1.2 1.5
Noisy workplace 0.1 0.1 0.8 -0.9 -0.0 0.1 -0.1 -0.1 -0.1
Qualifications: A levels/AS levels or equivalent 1.1 2.3 3.3 0.4 1.7 1.8 1.7 -1.2 -1.8
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.5 -0.7 0.2 0.4 0.0 -0.2 -0.3
Mouth/teeth dental problems: Dentures 0.2 0.4 0.9 0.4 -0.1 -0.3 -0.2 1.0 1.0
Asthma 0.2 0.5 0.9 0.4 1.0 1.0 0.8 -0.1 -0.3
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.5 0.7 0.2 0.2 0.4 -0.3 -0.3
Medication: Cholesterol lowering 0.2 0.3 0.6 -0.1 0.8 0.5 0.2 0.8 0.3
Depression (self-reported) 0.8 0.9 1.6 -1.3 -0.8 -0.8 -1.2 0.6 0.9
Medication: Lansoprazole 0.1 0.1 0.5 0.1 -0.7 -0.5 -0.1 -0.3 -0.0
Prospective memory result 1.1 1.3 5.3 2.3 0.9 0.9 1.0 -0.1 -0.4
Lung cancer (father) 2.6 3.0 4.5 -2.1 -1.8 -1.9 -2.0 0.9 1.6
Illnesses of mother 0.2 0.2 0.7 0.1 -0.2 -0.1 0.2 -0.8 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.1 4.0 -0.1 0.7 0.6 -0.3 2.0 1.3
Pulse wave Arterial Stiffness index 0.1 0.2 0.4 -0.4 -0.3 -0.1 -0.1 -0.6 -0.6
Impedance of arm (left) 1.2 5.3 8.9 3.0 0.9 1.3 2.4 -2.8 -2.7
Arm fat mass (right) 0.4 1.7 3.9 -1.0 2.0 1.6 0.6 1.5 0.4
Trunk predicted mass 1.2 6.7 18.3 -2.8 1.3 0.8 -1.4 4.3 3.1
Standing height 0.4 4.3 11.4 -0.7 2.4 2.2 0.1 3.4 1.9
Length of working week for main job 0.1 0.1 0.3 -0.5 0.3 0.2 -0.1 0.5 0.3
Exposure to tobacco smoke at home 1.2 1.3 1.9 -1.4 -1.2 -1.2 -1.4 0.5 1.0
Breastfed as a baby 5.9 7.3 10.3 3.0 2.7 2.9 3.2 -1.6 -2.6
Tense / ‘highly strung’ 0.3 0.4 0.8 0.3 0.9 0.8 0.2 0.9 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.0 0.0 0.1 -0.0 -0.1 -0.2 -0.2 0.3 0.3
Hair/balding pattern: Pattern 4 0.9 2.2 3.3 -1.4 -0.9 -0.9 -1.7 1.8 1.8
Birth weight of first child 1.8 3.2 5.0 1.1 1.7 1.9 2.0 -1.7 -2.2
Peak expiratory flow (PEF) 0.6 1.3 3.1 -1.6 0.5 0.5 -0.5 1.8 1.3
Pulse wave reflection index 0.2 0.2 0.6 -0.1 -0.8 -0.7 -0.3 -0.5 -0.1
Ever highly irritable/argumentative for 2 days 0.6 0.7 1.6 -0.6 -0.2 -0.4 -0.8 1.3 1.1
Loud music exposure frequency 2.2 2.4 3.8 -1.6 -1.1 -1.2 -1.6 1.7 1.9
Qualifications: O levels/GCSEs or equivalent 0.5 0.9 1.6 -0.7 1.3 1.3 0.7 -0.3 -0.9
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 1.3 -0.3 -0.9 -1.1 -1.0 0.7 1.0
Blood clot in the leg (DVT) 0.0 0.0 0.0 -0.1 -0.0 -0.1 -0.1 0.1 0.1
Medication: Paracetamol 1.0 1.7 2.9 -0.8 -1.5 -1.7 -1.5 0.6 1.2
Headache pain in last month 0.5 0.9 1.4 0.3 0.9 1.0 1.1 -0.7 -1.2
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 2.0 0.7 -0.8 -0.4 0.2 -1.4 -0.8
Glaucoma (self-reported) 0.2 0.3 0.5 0.7 -0.6 -0.7 0.0 -0.3 0.0
Gout (self-reported) 0.7 1.0 2.3 -1.5 0.4 0.3 -0.5 1.5 1.1
Hypothyroidism/myxoedema (self-reported) 0.5 1.1 2.5 0.3 1.4 1.1 0.4 1.6 0.8
Medication: Amlodipine 1.1 1.5 3.3 -0.3 1.7 1.3 0.4 1.8 0.8
Medication: Ventolin 100micrograms inhaler 0.4 0.5 0.8 0.8 0.8 0.8 0.9 0.1 -0.2
Birth weight 4.9 10.6 15.3 2.9 3.6 3.7 3.9 -1.8 -3.2
Chronic bronchitis/emphysema (mother) 2.5 2.9 5.4 -1.5 -1.0 -1.2 -1.9 1.9 2.3
High blood pressure (siblings) 0.0 0.0 0.1 -0.2 -0.1 -0.3 0.1 -0.3 -0.2
Forced vital capacity (FVC), Best measure 0.5 1.8 6.3 0.1 0.9 0.8 -0.3 2.5 1.7
Body fat percentage 0.1 0.5 1.5 -0.3 1.2 0.9 0.8 0.2 -0.4
Leg fat percentage (right) 0.0 0.2 0.3 -0.6 0.4 0.2 0.5 -0.3 -0.4
Arm fat-free mass (right) 1.2 6.1 13.2 -3.4 0.4 -0.1 -1.8 3.6 3.0
Exposure to tobacco smoke outside home 0.2 0.3 1.1 1.0 0.1 0.1 0.2 0.7 0.6
Comparative body size at age 10 0.1 0.3 0.6 -0.8 0.6 0.6 -0.2 0.5 0.2
Number of full brothers 0.2 0.2 0.9 0.1 -0.3 -0.1 0.2 -1.0 -0.6
Worry too long after embarrassment 1.8 3.0 4.4 -1.0 -1.6 -1.9 -2.0 1.6 2.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.3 1.7 2.8 -0.8 -1.2 -1.4 -1.7 1.2 1.5
Wheeze or whistling in the chest in last year 0.2 0.4 1.4 0.0 0.5 0.2 -0.2 1.2 0.9
Number of children fathered 0.6 0.7 1.9 1.4 0.3 0.4 0.8 -0.7 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 2.5 2.9 7.6 1.2 0.3 0.7 1.4 -2.8 -2.5
Age at first live birth 0.5 0.9 1.4 1.1 0.6 0.7 1.0 -1.0 -1.2
Pulse wave peak to peak time 0.3 0.4 0.5 0.7 0.7 0.5 0.4 0.7 0.4
Health satisfaction 0.9 1.1 3.2 -1.1 0.6 0.5 -0.3 1.8 1.2
Shortness of breath walking on level ground 1.6 1.9 4.0 -2.0 -0.5 -0.6 -1.2 1.6 1.5
Qualifications: College or University degree 0.3 1.0 2.2 -0.4 0.7 1.0 0.7 -1.2 -1.5
Eye problems/disorders: None of the above 0.4 0.5 1.0 0.6 0.3 0.5 0.6 -1.0 -1.0
Mouth/teeth dental problems: Loose teeth 0.8 1.0 1.8 1.1 1.4 1.2 1.0 0.3 -0.3
Emphysema/chronic bronchitis 0.7 0.7 1.5 -0.5 -1.1 -1.2 -0.8 0.4 0.9
Medication for pain relief, constipation, heartburn 0.4 0.8 1.7 0.2 1.1 1.3 1.0 -0.3 -0.7
Neck or shoulder pain in last month 0.4 0.6 2.1 -1.4 0.1 0.0 -0.7 0.7 0.7
Medication: Blood pressure 0.3 0.5 1.5 -0.6 1.2 0.9 0.5 0.5 -0.1
Angina (self-reported) 0.2 0.3 1.5 1.2 -0.1 -0.1 0.3 -0.3 -0.2
Migraine (self-reported) 3.9 4.8 8.6 2.9 2.2 2.5 2.3 -1.0 -1.8
Medication: Ibuprofen 0.2 0.3 1.1 1.0 0.0 0.1 0.4 -0.5 -0.4
Medication: Allopurinol 0.3 0.3 0.8 -0.2 0.7 0.6 0.1 0.9 0.5
Medication: Omeprazole 1.0 1.1 1.9 -1.4 -1.2 -1.4 -1.1 0.1 0.7
Medication: Seretide 50 evohaler 0.5 0.6 2.0 -0.0 -0.1 0.0 0.4 -1.4 -1.2
Mean time to correctly identify matches 1.3 2.5 4.8 1.5 0.6 0.7 1.7 -2.2 -2.1
Heart disease (mother) 0.6 0.7 2.0 -0.5 0.0 -0.2 -0.6 1.4 1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 2.1 -1.4 -0.5 -0.5 -0.6 -0.1 0.3
Whole body fat mass 0.3 1.2 2.1 -1.3 1.4 0.9 0.2 1.4 0.7
Leg fat mass (right) 0.2 0.9 2.2 -1.5 1.1 0.7 0.1 1.2 0.6
Arm predicted mass (right) 1.3 6.5 14.6 -3.4 0.6 0.1 -1.8 3.8 3.1
Pulse rate, automated reading 1.6 5.3 8.4 1.7 1.9 2.0 2.7 -2.4 -2.9
Alcohol intake frequency. 0.2 0.5 0.9 0.6 0.9 0.9 0.5 0.9 0.5
Comparative height size at age 10 1.3 6.9 19.1 -2.4 0.5 -0.0 -1.9 4.4 3.6
Number of full sisters 1.4 1.6 5.5 0.9 -0.9 -0.5 0.4 -2.3 -1.5
Suffer from ‘nerves’ 1.0 1.6 2.2 -0.8 -1.2 -1.4 -1.5 1.1 1.5
Overall health rating 0.6 1.2 2.8 -1.7 -0.7 -0.8 -0.9 1.0 1.1
Chest pain or discomfort 0.2 0.3 0.8 -0.9 0.2 0.1 -0.5 0.7 0.5
Had major operations 1.3 1.5 5.1 -0.1 1.1 0.8 0.0 2.2 1.4
Age at last live birth 0.1 0.1 0.5 -0.7 0.2 0.2 -0.1 -0.3 -0.4
Family relationship satisfaction 1.1 1.3 2.8 -0.4 -0.6 -0.7 -1.2 1.7 1.6
Leg pain on walking 1.0 1.2 4.3 2.1 0.8 0.9 1.2 -0.1 -0.4
Qualifications: NVQ or HND or HNC or equivalent 3.6 4.3 7.1 -2.2 -1.0 -1.1 -2.1 2.7 2.7
Commuting to job workplace: Car/motor vehicle 1.3 1.5 2.2 -1.2 -0.7 -1.1 -1.4 1.3 1.5
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 0.9 0.8 1.0 0.7 0.4 1.0 0.5
Medication: Aspirin 0.2 0.3 0.8 0.9 -0.4 -0.4 0.0 -0.6 -0.2
Supplements: Vitamin C 2.0 2.4 4.3 -0.9 -1.9 -2.1 -1.8 0.5 1.4
Knee pain experienced in last month 0.3 0.5 1.1 0.1 1.1 0.9 0.8 0.4 -0.2
Hypertension (Self-reported) 0.4 1.2 4.0 -1.0 0.6 0.1 -0.5 2.0 1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.4 1.7 4.8 -2.2 -0.4 -0.5 -1.2 1.3 1.3
Illnesses of father: Heart disease 0.1 0.1 0.4 -0.2 -0.2 -0.1 0.1 -0.7 -0.6
Illnesses of siblings: Diabetes 2.1 2.6 4.0 -2.0 -0.6 -0.9 -1.6 2.0 2.0
Smoking status: Previous 0.1 0.2 0.4 -0.4 0.1 -0.0 -0.3 0.7 0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 3.0 -0.3 0.2 -0.0 -0.4 1.7 1.3
Whole body fat-free mass 1.1 6.5 17.4 -2.8 1.3 0.8 -1.4 4.2 3.0
Leg fat-free mass (right) 1.0 5.1 13.5 -2.6 1.5 1.0 -1.0 3.7 2.5
Arm fat percentage (left) 0.3 1.4 3.6 -0.1 1.9 1.6 1.3 0.1 -0.7
Average weekly red wine intake 0.0 0.0 0.1 -0.3 -0.0 0.1 -0.1 -0.1 -0.1
Handedness (chirality/laterality): Left-handed 1.3 1.6 3.2 1.8 1.0 1.1 1.4 -0.8 -1.2
Mood swings 1.6 2.9 5.0 -1.6 -0.6 -0.9 -1.9 2.2 2.2
Loneliness, isolation 1.3 1.8 2.9 0.2 -1.4 -1.5 -1.4 1.2 1.7
Long-standing illness, disability or infirmity 0.8 1.2 2.6 -1.1 1.3 1.0 0.1 1.6 0.9
Ever had bowel cancer screening 0.2 0.3 0.9 0.1 0.1 -0.1 -0.3 1.0 0.8
Diabetes diagnosed by doctor 0.5 0.8 1.5 1.1 1.2 0.9 0.9 0.7 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 2.3 -1.1 -1.3 -1.4 -1.5 0.5 1.0
Friendships satisfaction 0.8 1.0 1.4 -0.4 -1.2 -1.2 -1.1 0.7 1.1
Qualifications: nursing, teaching 0.5 0.8 1.2 0.3 0.8 1.0 1.0 -0.8 -1.1
Commuting to job workplace: Walk 1.3 1.4 1.9 -0.9 -1.2 -1.2 -1.3 1.0 1.4
Eye problems/disorders: Cataract 0.2 0.3 0.8 -0.3 -0.5 -0.4 -0.2 -0.9 -0.5
Mouth/teeth dental problems: Mouth ulcers 3.8 6.0 11.3 -0.8 -3.4 -3.3 -3.0 0.5 1.9
Medication for cholesterol 0.1 0.1 0.3 -0.4 -0.3 -0.2 -0.5 0.4 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.7 -0.5 -0.7 -0.9 -0.6 0.1 0.3
Back pain experienced in last month 0.4 0.5 1.2 -0.2 1.1 0.7 0.3 1.1 0.4
Mineral and other dietary supplements 0.7 0.9 2.0 -1.4 1.1 1.2 0.3 0.7 0.0
Breast cancer (self-reported) 3.4 4.1 6.9 1.2 2.5 2.6 2.5 -0.8 -1.7
Asthma (self-reported) 0.2 0.4 0.7 0.5 0.8 0.8 0.8 -0.2 -0.3
Osteoporosis (self-reported) 0.1 0.1 0.5 -0.7 0.5 0.2 0.1 0.2 -0.1
Osteoarthritis (self-reported) 1.0 1.3 4.0 0.6 -1.1 -0.9 0.1 -2.0 -1.2
Medication: Aspirin 0.2 0.3 0.7 0.8 -0.6 -0.6 -0.1 -0.5 -0.1
Medication: Gliclazide 0.4 0.5 0.9 -0.1 0.9 0.9 0.7 -0.3 -0.8
Illnesses of father: None of the above (group 1) 1.7 2.1 4.0 -0.7 -1.1 -1.2 -1.7 1.6 2.0
Smoking status: Current 0.2 0.2 0.7 0.1 -0.8 -0.8 -0.3 -0.2 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.3 1.6 1.2 0.1 -0.1 0.2 0.3 0.1
Whole body water mass 1.2 6.7 17.8 -2.9 1.2 0.7 -1.5 4.2 3.1
Leg predicted mass (right) 1.0 5.3 13.9 -2.6 1.5 1.0 -1.0 3.7 2.5
Arm fat mass (left) 0.4 1.6 3.3 -1.1 1.8 1.4 0.5 1.6 0.6
Number of self-reported non-cancer illnesses 0.7 1.3 2.8 -0.3 1.6 1.3 0.4 1.7 0.7
Average weekly champagne plus white wine intake 0.8 1.2 3.2 0.4 -0.1 -0.4 -0.9 1.8 1.6
Miserableness 3.4 5.9 10.2 -2.6 -1.0 -1.3 -2.5 3.1 3.2
Guilty feelings 0.5 0.7 2.1 -0.7 0.5 0.3 -0.5 1.4 1.1
Wears glasses or contact lenses 0.7 0.8 3.5 1.9 0.7 0.3 0.6 0.5 0.0
Ever taken oral contraceptive pill 4.7 5.2 7.3 -2.0 -2.6 -2.7 -2.7 1.2 2.1
Hearing aid user 0.4 0.4 0.7 0.9 0.6 0.6 0.8 -0.3 -0.6
Mother’s age at death 6.8 8.5 10.4 2.8 2.9 3.1 3.2 -2.1 -3.2
Financial situation satisfaction 0.3 0.3 1.0 -0.2 0.1 0.0 -0.5 1.0 0.8
Tinnitus: Yes, now most or all of the time 0.5 0.5 1.1 1.0 -0.3 -0.3 -0.3 1.0 1.0
Commuting to job workplace: Public transport 2.7 3.3 4.6 1.5 1.9 2.2 2.1 -1.1 -1.9
Eye problems/disorders: Glaucoma 0.1 0.2 0.5 0.4 -0.6 -0.7 -0.0 -0.1 0.2
Medication: Blood pressure 0.1 0.3 0.7 0.0 0.8 0.5 0.4 0.7 0.3
Pain type(s) experienced in last month: Hip pain 0.7 0.8 1.3 1.1 1.1 1.0 1.2 0.2 -0.3
Supplements: Fish oil (including cod liver oil) 0.2 0.3 1.2 1.1 -0.4 -0.5 -0.0 0.1 0.3
High cholesterol (Self-reported) 0.1 0.1 0.3 0.5 -0.3 -0.3 0.2 -0.4 -0.3
Medication: Bendroflumethiazide 0.5 0.8 1.9 -0.4 1.4 1.0 0.5 1.0 0.3
Medication: Paracetamol 0.7 1.0 2.1 -0.3 -1.3 -1.4 -1.1 0.3 0.9
Medication: Lisinopril 0.3 0.5 1.3 0.0 1.1 0.9 0.5 0.5 -0.0
Medication: Atorvastatin 1.3 1.6 3.5 1.9 1.2 1.1 1.6 -0.4 -0.8
Illnesses of father: High blood pressure 0.9 1.1 2.9 -1.4 0.6 0.4 -0.4 1.7 1.1
Alcohol drinker status: Never 0.2 0.3 0.6 0.5 0.7 0.8 0.4 0.4 -0.0
Ever smoked 0.4 0.7 1.7 0.3 -1.3 -1.3 -0.4 -1.0 -0.2
Basal metabolic rate 1.2 6.5 17.6 -2.8 1.4 0.9 -1.3 4.2 3.0
Leg fat percentage (left) 0.0 0.1 0.4 -0.7 0.4 0.1 0.3 -0.1 -0.2
Arm fat-free mass (left) 1.4 7.0 17.6 -3.2 0.8 0.3 -1.8 4.2 3.2
Number of operations (self-reported) 0.1 0.2 0.5 -0.6 0.0 -0.2 -0.3 0.7 0.6
Average weekly beer plus cider intake 0.7 1.0 2.2 0.6 -1.5 -1.2 -0.3 -1.3 -0.4
Irritability 3.9 6.6 12.5 -2.0 -1.1 -1.6 -2.6 3.5 3.5
Risk taking 5.1 7.4 10.5 -3.2 -2.8 -2.9 -3.1 1.4 2.4
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.8 -0.2 -0.4 -0.5 -0.8 1.3 1.2
Fractured/broken bones in last 5 years 0.1 0.1 0.3 0.1 -0.2 -0.2 0.1 -0.6 -0.2
Age started oral contraceptive pill 3.9 4.9 6.6 1.7 2.2 2.4 2.6 -1.8 -2.5
Diastolic blood pressure, automated reading 0.3 1.0 2.6 -0.4 1.6 1.4 1.1 0.4 -0.4
Ever depressed for a whole week 0.1 0.1 0.4 0.5 0.1 -0.1 -0.1 0.6 0.5
Unable to work because of sickness or disability 1.7 2.2 3.1 -1.1 -1.5 -1.6 -1.8 1.1 1.7
Commuting to job workplace: Cycle 2.3 2.7 5.3 2.3 -1.5 -1.3 0.4 -2.3 -1.3
Myopia 0.8 1.1 2.6 -0.7 -0.4 -0.5 -1.1 1.6 1.4
Vascular/heart problems diagnosed by doctor 0.4 1.1 3.6 0.9 -0.7 -0.2 0.4 -1.9 -1.3
Cholesterol lowering medication 0.4 0.6 1.2 1.0 0.7 0.6 1.1 -0.4 -0.7
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.6 -0.8 -0.6 -0.6 -0.3 -0.3 0.0
Pain experienced in last month 0.3 0.4 1.0 -0.4 -1.0 -0.9 -0.8 -0.2 0.3
Supplements: Calcium 0.3 0.4 0.7 0.7 -0.8 -0.9 -0.2 -0.5 -0.0
Basal cell carcinoma (self-reported) 0.4 0.5 1.3 -0.9 -0.3 -0.2 0.1 -1.1 -0.8
Heart attack/myocardial infarction (self-reported) 0.5 0.6 1.6 1.3 0.9 0.8 0.8 0.2 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.0 0.0 0.0 0.1 0.0 0.0 -0.0 0.2 0.1
Heart disease (siblings) 1.2 1.5 3.6 0.9 0.2 0.5 1.1 -1.9 -1.7
Alcohol drinker status: Previous 0.4 0.5 2.3 1.5 0.4 0.3 0.7 -0.0 -0.2
Pack years of smoking 0.4 0.6 1.6 -1.3 1.0 0.9 0.3 0.4 -0.0
Impedance of whole body 0.7 3.7 7.7 2.6 -0.2 0.3 1.6 -2.8 -2.3
Leg fat mass (left) 0.3 1.2 2.9 -1.7 1.0 0.6 -0.1 1.4 0.8
Arm predicted mass (left) 1.6 8.0 19.8 -3.3 0.6 0.1 -2.0 4.5 3.5