Hub : Genes

EGLN1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0780	0.0220	1.9e-09	0.095	0.075	0.071	0.08	0.082	1.1e-11	1.7e-09	4.7e-09	5.6e-10	3.5e-10
2	GTEx	Muscle Skeletal	0.0894	0.0357	2.2e-03	0.071	NA	0.042	NA	0.047	1.6e-07	NA	5.2e-05	NA	1.9e-05
3	NTR	Blood	0.0199	0.0080	6.4e-04	0.019	0.006	0.010	0.01	0.012	6.6e-07	3.7e-03	3.3e-04	1.8e-04	7.3e-05
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0398	0.0219	5.8e-05	0.040	0.034	0.022	NA	0.030	2.2e-05	8.9e-05	1.5e-03	NA	2.3e-04
5	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0720	0.0480	2.9e-03	0.024	0.037	0.031	NA	0.026	1.6e-02	3.5e-03	6.4e-03	NA	1.2e-02
6	TCGA	Prostate Adenocarcinoma	0.0230	0.0178	6.0e-03	0.020	0.006	0.007	NA	0.013	2.9e-03	6.2e-02	5.5e-02	NA	1.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.2	1.9	4.7	-0.1	-2.2	-2.1	-1.0	-1.0	0.3
Bipolar Disorder or Schizophrenia	0.9	2.2	5.1	2.3	-0.3	-0.4	1.3	-2.0	-1.5
Depressed Affect (Nagel 2018)	3.0	6.2	10.9	-2.1	-1.5	-1.9	-2.8	3.0	3.3
Depression (Nagel 2018)	0.9	1.4	2.9	0.4	-1.6	-1.7	-1.1	0.3	1.1
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.8	-0.0	-0.2	-0.2	-0.7	0.8	0.9
Neuroticism (Nagel 2018)	2.2	5.2	9.7	-1.5	-1.3	-1.8	-2.3	3.1	3.1
Schizophrenia (2018)	2.1	4.5	9.2	3.0	1.4	1.2	2.6	-1.8	-2.1
Schizophrenia vs Biploar Disorder	1.5	2.0	4.8	0.3	2.2	2.2	1.3	0.4	-0.6
Worry (Nagel 2018)	0.4	0.9	2.5	0.1	0.1	-0.3	-0.6	1.6	1.5
Alzheimer’s Disease (in mother)	1.3	1.5	1.7	1.3	1.2	1.3	1.3	-0.9	-1.2
Alzheimer’s Disease (in father)	1.1	1.2	2.2	0.6	0.7	0.8	1.3	-1.5	-1.5
Alzheimer’s Disease (including proxy)	0.9	1.2	2.5	1.0	0.5	0.7	1.1	-1.6	-1.4
Crohns Disease (2017)	0.7	1.6	2.6	1.5	1.5	1.5	1.6	0.2	-0.6
Irritable Bowel Disease (IBD)	0.3	0.8	1.6	1.2	0.8	0.8	1.1	-0.3	-0.7
Ulcerative Colitis (UC)	0.1	0.1	0.4	0.7	-0.1	-0.3	0.1	-0.3	-0.2
Major Depression (MDD)	0.6	0.8	1.5	-0.6	-1.2	-1.1	-1.1	0.2	0.6
Reaction Time	0.3	0.6	2.0	0.4	-0.3	-0.2	0.5	-1.4	-1.0
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.7	-0.5	0.7	0.7	0.0	0.9	0.5
Breast Cancer	3.5	8.4	13.2	-3.6	-2.5	-2.7	-3.5	2.0	2.8
Ovarian Cancer	1.7	2.2	5.1	2.3	1.0	1.1	1.7	-1.1	-1.3
Prostate Cancer	0.6	0.9	1.8	0.2	1.3	1.4	0.7	1.0	0.2
Age at First Birth	0.8	1.2	2.0	1.2	1.1	1.2	1.4	-0.6	-1.0
Bipolar Disorder (2011)	1.1	1.1	2.7	0.3	-1.6	-1.5	-0.6	-1.1	-0.1
Body Mass Index (BMI) (2010)	0.1	0.2	0.4	0.3	0.5	0.6	0.5	-0.1	-0.4
Coronary Artery Disease (CAD)	0.7	0.8	1.7	-0.3	0.6	0.8	0.9	-1.3	-1.2
Crohns Disease (2012)	1.0	1.6	2.7	1.4	1.2	1.4	1.6	-0.7	-1.1
Mean Putamen Volume	0.5	0.5	2.0	-1.4	0.1	0.0	-0.6	0.7	0.6
Fasting Glucose	0.1	0.1	0.1	-0.2	-0.2	-0.3	0.2	0.4	-0.0
HbA1C	2.9	3.2	6.6	1.7	-0.9	-1.0	2.2	-1.8	-2.6
HDL Cholesterol	0.4	0.7	1.8	0.5	1.3	1.2	0.9	0.2	-0.4
LDL Cholesterol	0.8	1.3	2.9	0.9	1.6	1.7	1.1	0.4	-0.3
Lupus	0.3	0.4	1.6	1.3	0.3	0.2	0.7	-0.4	-0.4
Neuroticism (2016)	1.1	1.6	2.1	-1.2	-1.2	-1.3	-1.3	0.9	1.5
Primary Biliary Cirrhosis	0.2	0.3	1.7	1.3	0.2	0.1	0.4	0.3	0.2
Rheumatoid Arthritis	0.2	0.3	0.5	0.7	0.5	0.4	0.6	-0.3	-0.5
Schizophrenia (2014)	0.9	1.9	3.2	1.8	0.6	0.6	1.6	-1.6	-1.6
Triglycerides	0.9	1.4	2.0	-1.4	-0.8	-0.9	-1.4	1.3	1.3
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.3	-0.5	0.5	0.5	0.1	0.3	0.3
Ulcerative Colitis	0.2	0.3	0.7	0.4	0.1	0.1	0.7	-0.9	-0.8
Blood Eosinophil Count	0.1	1.0	1.8	-1.3	-0.6	-0.8	-1.0	0.9	1.1
Blood Platelet Count	0.2	2.3	5.5	-2.3	-0.5	-0.7	-1.6	1.5	1.6
Blood Red Count	6.3	60.6	161.3	2.4	1.8	3.2	7.3	-12.7	-11.4
Blood White Count	0.2	1.1	2.3	-0.6	-1.4	-1.5	-1.2	0.2	0.9
Heel T-Score	0.3	2.4	4.2	-0.8	-2.0	-2.0	-1.5	0.8	1.6
BMI	0.1	0.6	2.0	-1.4	0.2	-0.3	-0.3	0.9	0.7
Height	0.4	7.7	15.8	0.8	4.0	3.7	1.6	3.5	1.3
Waist Hip Ratio (WHR)	0.1	0.4	1.0	-0.2	-0.7	-0.5	0.3	-1.0	-0.6
Systolic Blood Pressure	0.2	1.2	2.0	0.4	1.2	1.1	1.4	-0.7	-1.3
Smoking Status	0.3	0.7	0.9	-0.8	-0.8	-0.9	-0.9	0.6	0.9
Allergy or Eczema	0.5	1.3	3.3	-0.6	-0.1	-0.3	-1.1	1.8	1.7
Cardiovascular Disease	0.8	2.7	6.4	-2.0	0.1	-0.3	-1.2	2.5	2.1
Hypothyroidism (self reported)	0.3	0.7	2.2	0.2	0.7	0.4	-0.1	1.5	1.0
Respiratory disease	0.8	1.8	2.8	1.0	1.0	1.2	1.5	-1.7	-1.6
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.7	0.4	1.3	1.0	1.1	0.1	-0.6
Lung FEV1/FVC ratio	0.5	2.8	5.3	0.5	2.2	2.3	1.9	-0.6	-1.6
Lung FVC	0.1	0.3	0.4	0.3	-0.5	-0.5	-0.6	0.5	0.5
Neuroticism	1.9	4.5	7.7	-1.6	-1.4	-1.7	-2.3	2.5	2.8
Chronotype (morning person)	0.1	0.3	0.9	0.2	0.5	0.3	0.0	1.0	0.5
Hair Pigment	0.2	6.3	15.8	-0.6	-4.0	-3.7	-2.4	-1.3	0.7
Tanning	0.1	1.5	5.0	0.4	-0.9	-0.7	0.4	-2.2	-1.6
Hand grip strength (left)	3.4	9.0	13.0	3.1	3.5	3.5	3.6	-1.0	-2.4
Number of treatments/medications taken	0.9	1.5	5.4	-0.1	0.6	0.0	-0.5	2.3	1.8
Average weekly spirits intake	1.2	1.4	3.3	1.8	0.5	0.4	1.4	-1.2	-1.3
Sensitivity / hurt feelings	1.4	2.4	4.3	-1.2	-1.0	-1.3	-1.6	1.9	2.1
Frequency of depressed mood in last 2 weeks	0.3	0.5	0.8	-0.2	-0.7	-0.8	-0.8	0.5	0.9
Hearing difficulty/problems: Yes	0.2	0.3	0.9	-0.1	0.9	0.9	0.2	0.6	0.1
Relative age of first facial hair	1.4	2.9	4.6	2.1	1.5	1.6	1.8	-1.3	-1.8
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.8	-0.1	-0.0	0.1	0.6	-1.4	-1.1
Ever used hormone-replacement therapy (HRT)	1.8	2.3	3.8	-1.9	-1.6	-1.9	-1.6	0.6	1.2
Ever had hysterectomy (womb removed)	0.5	0.6	2.2	-1.5	-0.2	-0.2	-0.7	0.6	0.5
Systolic blood pressure, automated reading	0.9	2.7	4.4	1.2	2.1	1.9	2.0	-0.7	-1.5
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.2	1.5	0.7	0.7	0.9	-0.4	-0.7
Angina	0.3	0.4	2.0	1.4	-0.1	-0.1	0.3	-0.2	-0.1
Medication for hormone replacement therapy	0.5	0.5	1.1	-0.3	-1.1	-1.0	-0.8	-0.2	0.3
Vitamin and mineral supplements	0.8	1.1	2.3	0.3	1.4	1.5	1.1	-0.3	-1.0
Supplements: Zinc	0.7	0.7	2.7	1.6	-0.4	-0.3	0.5	-0.9	-0.6
Medication: Co-codamol	1.0	1.1	3.1	1.8	1.1	1.0	1.1	0.1	-0.2
Medication: Metformin	1.2	1.7	2.2	1.2	1.4	1.3	1.5	-0.9	-1.5
Diabetes (father)	1.0	1.2	4.4	-2.1	-0.1	0.0	-0.9	1.1	0.9
Diabetes (mother)	0.5	0.7	1.7	-0.6	-0.1	-0.3	-0.6	1.3	1.2
Severe depression (siblings)	0.2	0.2	0.5	0.7	0.3	0.4	0.4	-0.3	-0.4
Pack years adult smoking proportion	0.4	0.6	2.1	-1.5	0.8	0.7	-0.0	0.7	0.3
Impedance of leg (right)	0.4	2.0	5.5	1.5	-1.2	-0.8	0.5	-2.4	-1.4
Leg fat-free mass (left)	1.0	5.2	13.5	-2.7	1.7	1.1	-0.9	3.7	2.4
Trunk fat percentage	0.2	0.9	2.3	-0.1	1.5	1.2	1.1	0.2	-0.4
Hand grip strength (right)	1.5	4.1	6.2	1.8	2.5	2.5	2.5	-0.6	-1.6
Townsend deprivation index at recruitment	0.6	0.9	2.1	1.0	-0.9	-0.8	0.1	-1.4	-0.7
Current tobacco smoking	0.1	0.1	0.4	0.1	-0.6	-0.6	-0.2	-0.0	0.2
Average weekly fortified wine intake	0.2	0.2	0.7	-0.4	0.1	-0.1	-0.4	0.8	0.7
Maternal smoking around birth	2.6	3.8	5.2	-1.8	-2.2	-2.3	-2.3	1.0	1.9
Fed-up feelings	3.0	5.5	9.1	-2.0	-1.5	-1.9	-2.6	2.6	3.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.0	-0.5	-1.4	-1.4	-1.1	0.4	1.0
Relative age voice broke	0.8	1.2	2.3	1.5	0.1	0.3	0.9	-1.5	-1.4
Taking other prescription medications	1.2	1.8	6.2	-0.6	0.6	0.2	-0.6	2.5	1.8
Age when periods started (menarche)	1.0	2.4	5.9	1.9	-0.3	0.1	1.1	-2.4	-1.9
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	2.0	-1.4	-0.1	-0.1	-0.2	-0.1	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.1	-0.3	-1.1	-1.0	-0.8	0.2	0.5
Tinnitus: Yes, but not now, but have in the past	6.6	7.0	9.7	-3.0	-1.7	-2.0	-2.9	2.8	3.1
Qualifications: CSEs or equivalent	9.6	12.7	18.6	-2.2	-4.2	-4.3	-4.2	2.0	3.7
Serious illness, injury or assault to yourself	0.1	0.1	0.2	-0.4	0.0	-0.0	-0.2	0.3	0.3
High blood pressure	0.5	1.3	4.2	-0.9	0.6	0.1	-0.5	2.1	1.4
Hayfever, allergic rhinitis or eczema	0.9	2.0	4.0	-0.8	-0.7	-0.8	-1.5	1.9	2.0
Multivitamins +/- minerals	1.0	1.2	2.3	-0.9	-1.5	-1.5	-1.2	0.2	0.8
Stomach or abdominal pain in last month	0.2	0.2	0.4	-0.6	-0.3	-0.3	-0.6	0.4	0.5
Supplements: Glucosamine	1.2	1.5	2.7	1.6	0.4	0.6	1.2	-1.6	-1.5
Diverticular disease/diverticulitis (self-reported)	1.9	2.3	5.2	-0.9	-2.2	-2.3	-1.6	-0.4	0.5
Medication: Atenolol	0.1	0.1	0.8	-0.9	0.1	-0.2	-0.1	0.2	0.1
Medication: Levothyroxine sodium	1.3	2.2	5.2	0.7	2.3	2.0	1.1	1.6	0.4
Sitting height	1.2	8.5	26.8	-1.7	2.2	1.7	-1.1	5.2	3.5
Chronic bronchitis/emphysema (father)	1.7	2.0	3.7	1.9	0.9	0.9	1.6	-1.4	-1.5
High blood pressure (mother)	0.1	0.2	0.3	-0.4	0.5	0.6	0.0	0.5	0.3
Body mass index (BMI)	0.2	0.9	2.0	-1.4	0.9	0.4	-0.2	1.4	0.8
Impedance of leg (left)	0.4	2.0	4.9	1.5	-1.5	-1.0	0.3	-2.2	-1.2
Leg predicted mass (left)	1.0	5.1	13.1	-2.6	1.6	1.1	-0.9	3.6	2.4
Trunk fat mass	0.3	1.3	2.7	-1.0	1.6	1.2	0.5	1.4	0.5
Waist circumference	0.2	0.8	1.5	-1.1	1.2	0.9	0.4	1.0	0.3
Number of incorrect matches in round	0.5	0.8	1.9	0.3	-1.2	-1.4	-0.7	0.3	0.7
Past tobacco smoking	0.2	0.3	0.7	0.0	0.8	0.8	0.5	-0.1	-0.5
Alcohol usually taken with meals	0.3	0.5	1.3	-0.3	1.1	1.0	0.5	0.3	-0.2
Nervous feelings	0.7	1.4	2.4	1.3	1.5	1.2	0.6	1.3	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	3.6	-1.9	-0.6	-0.6	-1.0	0.6	0.8
Hearing difficulty/problems with background noise	0.2	0.3	0.8	0.6	0.9	0.7	0.5	0.4	0.0
Hair/balding pattern: Pattern 2	0.3	0.4	0.7	0.7	0.8	0.7	0.7	0.1	-0.3
Had menopause	0.3	0.4	1.5	-0.3	-0.1	0.1	0.2	-1.2	-1.0
Had other major operations	0.2	0.3	0.5	-0.2	-0.7	-0.7	-0.5	0.2	0.5
Forced vital capacity (FVC)	0.8	3.0	8.0	-1.5	0.1	-0.1	-1.4	2.8	2.3
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.3	-0.5	-0.3	-0.3	-0.2	0.1	0.1
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	-0.4	-0.1	-0.3	-0.3	0.2	0.3
Qualifications: None of the above	0.1	0.3	0.6	0.6	-0.3	-0.5	-0.5	0.6	0.8
Financial difficulties in last 2 years	1.1	1.4	2.1	-1.2	-1.4	-1.3	-1.4	0.6	1.1
Mouth/teeth dental problems	2.4	3.6	6.0	-0.0	1.9	2.2	2.1	-1.8	-2.4
Heart attack	0.4	0.6	1.4	1.2	0.9	0.8	0.6	0.4	0.1
Allergy	0.2	0.5	1.2	0.1	0.1	0.2	0.6	-1.1	-1.1
Pain all over the body in last month	0.4	0.4	1.2	1.1	-0.2	-0.2	0.3	-1.0	-0.6
Diabetes (self-reported)	1.0	1.5	2.7	1.5	1.6	1.4	1.4	0.2	-0.6
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.6	-1.3	-0.9	-0.8	-0.5	-0.6	-0.2
Medication: Ramipril	0.1	0.1	0.7	-0.9	0.1	0.0	-0.0	0.1	-0.1
Medication: Simvastatin	0.1	0.1	0.3	-0.1	-0.1	-0.3	-0.4	0.5	0.5
Fluid intelligence score	0.3	0.6	1.5	-0.0	1.2	1.2	0.6	0.3	-0.2
Illnesses of siblings	0.1	0.1	0.2	0.4	0.1	0.2	-0.2	0.4	0.3
Neuroticism score	3.0	6.3	12.6	-1.8	-1.0	-1.4	-2.6	3.5	3.5
Weight	0.7	3.4	8.9	-1.8	1.8	1.3	-0.2	3.0	1.8
Impedance of arm (right)	1.2	5.5	10.0	3.2	1.2	1.6	2.4	-2.4	-2.6
Arm fat percentage (right)	0.4	1.7	4.5	0.2	2.1	1.8	1.4	0.3	-0.7
Trunk fat-free mass	1.2	6.6	18.2	-2.7	1.3	0.9	-1.4	4.3	3.1
Hip circumference	0.4	1.7	4.0	-0.9	1.6	1.2	0.1	2.0	1.1
Time employed in main current job	0.9	1.0	1.8	-0.8	-0.9	-1.3	-1.2	0.6	1.0
Alcohol intake versus 10 years previously	0.1	0.2	0.4	0.2	0.4	0.5	0.6	-0.4	-0.5
Father’s age at death	2.2	2.9	5.0	1.1	1.3	1.6	1.8	-1.9	-2.2
Worrier / anxious feelings	0.2	0.4	0.8	-0.1	0.8	0.7	0.2	0.9	0.5
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.9	2.7	-1.1	-1.2	-1.4	-1.6	1.2	1.6
Falls in the last year	0.4	0.6	1.4	0.0	-1.1	-1.2	-0.8	-0.5	0.1
Hair/balding pattern: Pattern 3	1.0	1.4	2.9	-0.8	-0.7	-0.9	-1.1	1.5	1.7
Number of live births	0.1	0.2	0.5	-0.0	0.7	0.5	0.4	0.2	-0.0
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	6.2	-1.7	0.1	0.0	-1.3	2.5	2.0
Pulse rate	1.7	2.8	4.6	1.8	0.8	1.0	1.7	-2.1	-2.2
Happiness	0.9	1.1	2.2	-0.1	-0.9	-0.9	-1.1	1.2	1.5
Noisy workplace	0.1	0.1	0.8	-0.9	-0.0	0.1	-0.1	-0.1	-0.1
Qualifications: A levels/AS levels or equivalent	1.1	2.3	3.3	0.4	1.7	1.8	1.7	-1.2	-1.8
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.5	-0.7	0.2	0.4	0.0	-0.2	-0.3
Mouth/teeth dental problems: Dentures	0.2	0.4	0.9	0.4	-0.1	-0.3	-0.2	1.0	1.0
Asthma	0.2	0.5	0.9	0.4	1.0	1.0	0.8	-0.1	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.5	0.7	0.2	0.2	0.4	-0.3	-0.3
Medication: Cholesterol lowering	0.2	0.3	0.6	-0.1	0.8	0.5	0.2	0.8	0.3
Depression (self-reported)	0.8	0.9	1.6	-1.3	-0.8	-0.8	-1.2	0.6	0.9
Medication: Lansoprazole	0.1	0.1	0.5	0.1	-0.7	-0.5	-0.1	-0.3	-0.0
Prospective memory result	1.1	1.3	5.3	2.3	0.9	0.9	1.0	-0.1	-0.4
Lung cancer (father)	2.6	3.0	4.5	-2.1	-1.8	-1.9	-2.0	0.9	1.6
Illnesses of mother	0.2	0.2	0.7	0.1	-0.2	-0.1	0.2	-0.8	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	4.0	-0.1	0.7	0.6	-0.3	2.0	1.3
Pulse wave Arterial Stiffness index	0.1	0.2	0.4	-0.4	-0.3	-0.1	-0.1	-0.6	-0.6
Impedance of arm (left)	1.2	5.3	8.9	3.0	0.9	1.3	2.4	-2.8	-2.7
Arm fat mass (right)	0.4	1.7	3.9	-1.0	2.0	1.6	0.6	1.5	0.4
Trunk predicted mass	1.2	6.7	18.3	-2.8	1.3	0.8	-1.4	4.3	3.1
Standing height	0.4	4.3	11.4	-0.7	2.4	2.2	0.1	3.4	1.9
Length of working week for main job	0.1	0.1	0.3	-0.5	0.3	0.2	-0.1	0.5	0.3
Exposure to tobacco smoke at home	1.2	1.3	1.9	-1.4	-1.2	-1.2	-1.4	0.5	1.0
Breastfed as a baby	5.9	7.3	10.3	3.0	2.7	2.9	3.2	-1.6	-2.6
Tense / ‘highly strung’	0.3	0.4	0.8	0.3	0.9	0.8	0.2	0.9	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.1	-0.0	-0.1	-0.2	-0.2	0.3	0.3
Hair/balding pattern: Pattern 4	0.9	2.2	3.3	-1.4	-0.9	-0.9	-1.7	1.8	1.8
Birth weight of first child	1.8	3.2	5.0	1.1	1.7	1.9	2.0	-1.7	-2.2
Peak expiratory flow (PEF)	0.6	1.3	3.1	-1.6	0.5	0.5	-0.5	1.8	1.3
Pulse wave reflection index	0.2	0.2	0.6	-0.1	-0.8	-0.7	-0.3	-0.5	-0.1
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.6	-0.6	-0.2	-0.4	-0.8	1.3	1.1
Loud music exposure frequency	2.2	2.4	3.8	-1.6	-1.1	-1.2	-1.6	1.7	1.9
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	1.6	-0.7	1.3	1.3	0.7	-0.3	-0.9
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.3	-0.3	-0.9	-1.1	-1.0	0.7	1.0
Blood clot in the leg (DVT)	0.0	0.0	0.0	-0.1	-0.0	-0.1	-0.1	0.1	0.1
Medication: Paracetamol	1.0	1.7	2.9	-0.8	-1.5	-1.7	-1.5	0.6	1.2
Headache pain in last month	0.5	0.9	1.4	0.3	0.9	1.0	1.1	-0.7	-1.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	2.0	0.7	-0.8	-0.4	0.2	-1.4	-0.8
Glaucoma (self-reported)	0.2	0.3	0.5	0.7	-0.6	-0.7	0.0	-0.3	0.0
Gout (self-reported)	0.7	1.0	2.3	-1.5	0.4	0.3	-0.5	1.5	1.1
Hypothyroidism/myxoedema (self-reported)	0.5	1.1	2.5	0.3	1.4	1.1	0.4	1.6	0.8
Medication: Amlodipine	1.1	1.5	3.3	-0.3	1.7	1.3	0.4	1.8	0.8
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.8	0.8	0.8	0.8	0.9	0.1	-0.2
Birth weight	4.9	10.6	15.3	2.9	3.6	3.7	3.9	-1.8	-3.2
Chronic bronchitis/emphysema (mother)	2.5	2.9	5.4	-1.5	-1.0	-1.2	-1.9	1.9	2.3
High blood pressure (siblings)	0.0	0.0	0.1	-0.2	-0.1	-0.3	0.1	-0.3	-0.2
Forced vital capacity (FVC), Best measure	0.5	1.8	6.3	0.1	0.9	0.8	-0.3	2.5	1.7
Body fat percentage	0.1	0.5	1.5	-0.3	1.2	0.9	0.8	0.2	-0.4
Leg fat percentage (right)	0.0	0.2	0.3	-0.6	0.4	0.2	0.5	-0.3	-0.4
Arm fat-free mass (right)	1.2	6.1	13.2	-3.4	0.4	-0.1	-1.8	3.6	3.0
Exposure to tobacco smoke outside home	0.2	0.3	1.1	1.0	0.1	0.1	0.2	0.7	0.6
Comparative body size at age 10	0.1	0.3	0.6	-0.8	0.6	0.6	-0.2	0.5	0.2
Number of full brothers	0.2	0.2	0.9	0.1	-0.3	-0.1	0.2	-1.0	-0.6
Worry too long after embarrassment	1.8	3.0	4.4	-1.0	-1.6	-1.9	-2.0	1.6	2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	2.8	-0.8	-1.2	-1.4	-1.7	1.2	1.5
Wheeze or whistling in the chest in last year	0.2	0.4	1.4	0.0	0.5	0.2	-0.2	1.2	0.9
Number of children fathered	0.6	0.7	1.9	1.4	0.3	0.4	0.8	-0.7	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	2.5	2.9	7.6	1.2	0.3	0.7	1.4	-2.8	-2.5
Age at first live birth	0.5	0.9	1.4	1.1	0.6	0.7	1.0	-1.0	-1.2
Pulse wave peak to peak time	0.3	0.4	0.5	0.7	0.7	0.5	0.4	0.7	0.4
Health satisfaction	0.9	1.1	3.2	-1.1	0.6	0.5	-0.3	1.8	1.2
Shortness of breath walking on level ground	1.6	1.9	4.0	-2.0	-0.5	-0.6	-1.2	1.6	1.5
Qualifications: College or University degree	0.3	1.0	2.2	-0.4	0.7	1.0	0.7	-1.2	-1.5
Eye problems/disorders: None of the above	0.4	0.5	1.0	0.6	0.3	0.5	0.6	-1.0	-1.0
Mouth/teeth dental problems: Loose teeth	0.8	1.0	1.8	1.1	1.4	1.2	1.0	0.3	-0.3
Emphysema/chronic bronchitis	0.7	0.7	1.5	-0.5	-1.1	-1.2	-0.8	0.4	0.9
Medication for pain relief, constipation, heartburn	0.4	0.8	1.7	0.2	1.1	1.3	1.0	-0.3	-0.7
Neck or shoulder pain in last month	0.4	0.6	2.1	-1.4	0.1	0.0	-0.7	0.7	0.7
Medication: Blood pressure	0.3	0.5	1.5	-0.6	1.2	0.9	0.5	0.5	-0.1
Angina (self-reported)	0.2	0.3	1.5	1.2	-0.1	-0.1	0.3	-0.3	-0.2
Migraine (self-reported)	3.9	4.8	8.6	2.9	2.2	2.5	2.3	-1.0	-1.8
Medication: Ibuprofen	0.2	0.3	1.1	1.0	0.0	0.1	0.4	-0.5	-0.4
Medication: Allopurinol	0.3	0.3	0.8	-0.2	0.7	0.6	0.1	0.9	0.5
Medication: Omeprazole	1.0	1.1	1.9	-1.4	-1.2	-1.4	-1.1	0.1	0.7
Medication: Seretide 50 evohaler	0.5	0.6	2.0	-0.0	-0.1	0.0	0.4	-1.4	-1.2
Mean time to correctly identify matches	1.3	2.5	4.8	1.5	0.6	0.7	1.7	-2.2	-2.1
Heart disease (mother)	0.6	0.7	2.0	-0.5	0.0	-0.2	-0.6	1.4	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	2.1	-1.4	-0.5	-0.5	-0.6	-0.1	0.3
Whole body fat mass	0.3	1.2	2.1	-1.3	1.4	0.9	0.2	1.4	0.7
Leg fat mass (right)	0.2	0.9	2.2	-1.5	1.1	0.7	0.1	1.2	0.6
Arm predicted mass (right)	1.3	6.5	14.6	-3.4	0.6	0.1	-1.8	3.8	3.1
Pulse rate, automated reading	1.6	5.3	8.4	1.7	1.9	2.0	2.7	-2.4	-2.9
Alcohol intake frequency.	0.2	0.5	0.9	0.6	0.9	0.9	0.5	0.9	0.5
Comparative height size at age 10	1.3	6.9	19.1	-2.4	0.5	-0.0	-1.9	4.4	3.6
Number of full sisters	1.4	1.6	5.5	0.9	-0.9	-0.5	0.4	-2.3	-1.5
Suffer from ‘nerves’	1.0	1.6	2.2	-0.8	-1.2	-1.4	-1.5	1.1	1.5
Overall health rating	0.6	1.2	2.8	-1.7	-0.7	-0.8	-0.9	1.0	1.1
Chest pain or discomfort	0.2	0.3	0.8	-0.9	0.2	0.1	-0.5	0.7	0.5
Had major operations	1.3	1.5	5.1	-0.1	1.1	0.8	0.0	2.2	1.4
Age at last live birth	0.1	0.1	0.5	-0.7	0.2	0.2	-0.1	-0.3	-0.4
Family relationship satisfaction	1.1	1.3	2.8	-0.4	-0.6	-0.7	-1.2	1.7	1.6
Leg pain on walking	1.0	1.2	4.3	2.1	0.8	0.9	1.2	-0.1	-0.4
Qualifications: NVQ or HND or HNC or equivalent	3.6	4.3	7.1	-2.2	-1.0	-1.1	-2.1	2.7	2.7
Commuting to job workplace: Car/motor vehicle	1.3	1.5	2.2	-1.2	-0.7	-1.1	-1.4	1.3	1.5
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	0.9	0.8	1.0	0.7	0.4	1.0	0.5
Medication: Aspirin	0.2	0.3	0.8	0.9	-0.4	-0.4	0.0	-0.6	-0.2
Supplements: Vitamin C	2.0	2.4	4.3	-0.9	-1.9	-2.1	-1.8	0.5	1.4
Knee pain experienced in last month	0.3	0.5	1.1	0.1	1.1	0.9	0.8	0.4	-0.2
Hypertension (Self-reported)	0.4	1.2	4.0	-1.0	0.6	0.1	-0.5	2.0	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.7	4.8	-2.2	-0.4	-0.5	-1.2	1.3	1.3
Illnesses of father: Heart disease	0.1	0.1	0.4	-0.2	-0.2	-0.1	0.1	-0.7	-0.6
Illnesses of siblings: Diabetes	2.1	2.6	4.0	-2.0	-0.6	-0.9	-1.6	2.0	2.0
Smoking status: Previous	0.1	0.2	0.4	-0.4	0.1	-0.0	-0.3	0.7	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	3.0	-0.3	0.2	-0.0	-0.4	1.7	1.3
Whole body fat-free mass	1.1	6.5	17.4	-2.8	1.3	0.8	-1.4	4.2	3.0
Leg fat-free mass (right)	1.0	5.1	13.5	-2.6	1.5	1.0	-1.0	3.7	2.5
Arm fat percentage (left)	0.3	1.4	3.6	-0.1	1.9	1.6	1.3	0.1	-0.7
Average weekly red wine intake	0.0	0.0	0.1	-0.3	-0.0	0.1	-0.1	-0.1	-0.1
Handedness (chirality/laterality): Left-handed	1.3	1.6	3.2	1.8	1.0	1.1	1.4	-0.8	-1.2
Mood swings	1.6	2.9	5.0	-1.6	-0.6	-0.9	-1.9	2.2	2.2
Loneliness, isolation	1.3	1.8	2.9	0.2	-1.4	-1.5	-1.4	1.2	1.7
Long-standing illness, disability or infirmity	0.8	1.2	2.6	-1.1	1.3	1.0	0.1	1.6	0.9
Ever had bowel cancer screening	0.2	0.3	0.9	0.1	0.1	-0.1	-0.3	1.0	0.8
Diabetes diagnosed by doctor	0.5	0.8	1.5	1.1	1.2	0.9	0.9	0.7	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.3	-1.1	-1.3	-1.4	-1.5	0.5	1.0
Friendships satisfaction	0.8	1.0	1.4	-0.4	-1.2	-1.2	-1.1	0.7	1.1
Qualifications: nursing, teaching	0.5	0.8	1.2	0.3	0.8	1.0	1.0	-0.8	-1.1
Commuting to job workplace: Walk	1.3	1.4	1.9	-0.9	-1.2	-1.2	-1.3	1.0	1.4
Eye problems/disorders: Cataract	0.2	0.3	0.8	-0.3	-0.5	-0.4	-0.2	-0.9	-0.5
Mouth/teeth dental problems: Mouth ulcers	3.8	6.0	11.3	-0.8	-3.4	-3.3	-3.0	0.5	1.9
Medication for cholesterol	0.1	0.1	0.3	-0.4	-0.3	-0.2	-0.5	0.4	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.7	-0.5	-0.7	-0.9	-0.6	0.1	0.3
Back pain experienced in last month	0.4	0.5	1.2	-0.2	1.1	0.7	0.3	1.1	0.4
Mineral and other dietary supplements	0.7	0.9	2.0	-1.4	1.1	1.2	0.3	0.7	0.0
Breast cancer (self-reported)	3.4	4.1	6.9	1.2	2.5	2.6	2.5	-0.8	-1.7
Asthma (self-reported)	0.2	0.4	0.7	0.5	0.8	0.8	0.8	-0.2	-0.3
Osteoporosis (self-reported)	0.1	0.1	0.5	-0.7	0.5	0.2	0.1	0.2	-0.1
Osteoarthritis (self-reported)	1.0	1.3	4.0	0.6	-1.1	-0.9	0.1	-2.0	-1.2
Medication: Aspirin	0.2	0.3	0.7	0.8	-0.6	-0.6	-0.1	-0.5	-0.1
Medication: Gliclazide	0.4	0.5	0.9	-0.1	0.9	0.9	0.7	-0.3	-0.8
Illnesses of father: None of the above (group 1)	1.7	2.1	4.0	-0.7	-1.1	-1.2	-1.7	1.6	2.0
Smoking status: Current	0.2	0.2	0.7	0.1	-0.8	-0.8	-0.3	-0.2	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	1.6	1.2	0.1	-0.1	0.2	0.3	0.1
Whole body water mass	1.2	6.7	17.8	-2.9	1.2	0.7	-1.5	4.2	3.1
Leg predicted mass (right)	1.0	5.3	13.9	-2.6	1.5	1.0	-1.0	3.7	2.5
Arm fat mass (left)	0.4	1.6	3.3	-1.1	1.8	1.4	0.5	1.6	0.6
Number of self-reported non-cancer illnesses	0.7	1.3	2.8	-0.3	1.6	1.3	0.4	1.7	0.7
Average weekly champagne plus white wine intake	0.8	1.2	3.2	0.4	-0.1	-0.4	-0.9	1.8	1.6
Miserableness	3.4	5.9	10.2	-2.6	-1.0	-1.3	-2.5	3.1	3.2
Guilty feelings	0.5	0.7	2.1	-0.7	0.5	0.3	-0.5	1.4	1.1
Wears glasses or contact lenses	0.7	0.8	3.5	1.9	0.7	0.3	0.6	0.5	0.0
Ever taken oral contraceptive pill	4.7	5.2	7.3	-2.0	-2.6	-2.7	-2.7	1.2	2.1
Hearing aid user	0.4	0.4	0.7	0.9	0.6	0.6	0.8	-0.3	-0.6
Mother’s age at death	6.8	8.5	10.4	2.8	2.9	3.1	3.2	-2.1	-3.2
Financial situation satisfaction	0.3	0.3	1.0	-0.2	0.1	0.0	-0.5	1.0	0.8
Tinnitus: Yes, now most or all of the time	0.5	0.5	1.1	1.0	-0.3	-0.3	-0.3	1.0	1.0
Commuting to job workplace: Public transport	2.7	3.3	4.6	1.5	1.9	2.2	2.1	-1.1	-1.9
Eye problems/disorders: Glaucoma	0.1	0.2	0.5	0.4	-0.6	-0.7	-0.0	-0.1	0.2
Medication: Blood pressure	0.1	0.3	0.7	0.0	0.8	0.5	0.4	0.7	0.3
Pain type(s) experienced in last month: Hip pain	0.7	0.8	1.3	1.1	1.1	1.0	1.2	0.2	-0.3
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.2	1.1	-0.4	-0.5	-0.0	0.1	0.3
High cholesterol (Self-reported)	0.1	0.1	0.3	0.5	-0.3	-0.3	0.2	-0.4	-0.3
Medication: Bendroflumethiazide	0.5	0.8	1.9	-0.4	1.4	1.0	0.5	1.0	0.3
Medication: Paracetamol	0.7	1.0	2.1	-0.3	-1.3	-1.4	-1.1	0.3	0.9
Medication: Lisinopril	0.3	0.5	1.3	0.0	1.1	0.9	0.5	0.5	-0.0
Medication: Atorvastatin	1.3	1.6	3.5	1.9	1.2	1.1	1.6	-0.4	-0.8
Illnesses of father: High blood pressure	0.9	1.1	2.9	-1.4	0.6	0.4	-0.4	1.7	1.1
Alcohol drinker status: Never	0.2	0.3	0.6	0.5	0.7	0.8	0.4	0.4	-0.0
Ever smoked	0.4	0.7	1.7	0.3	-1.3	-1.3	-0.4	-1.0	-0.2
Basal metabolic rate	1.2	6.5	17.6	-2.8	1.4	0.9	-1.3	4.2	3.0
Leg fat percentage (left)	0.0	0.1	0.4	-0.7	0.4	0.1	0.3	-0.1	-0.2
Arm fat-free mass (left)	1.4	7.0	17.6	-3.2	0.8	0.3	-1.8	4.2	3.2
Number of operations (self-reported)	0.1	0.2	0.5	-0.6	0.0	-0.2	-0.3	0.7	0.6
Average weekly beer plus cider intake	0.7	1.0	2.2	0.6	-1.5	-1.2	-0.3	-1.3	-0.4
Irritability	3.9	6.6	12.5	-2.0	-1.1	-1.6	-2.6	3.5	3.5
Risk taking	5.1	7.4	10.5	-3.2	-2.8	-2.9	-3.1	1.4	2.4
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.8	-0.2	-0.4	-0.5	-0.8	1.3	1.2
Fractured/broken bones in last 5 years	0.1	0.1	0.3	0.1	-0.2	-0.2	0.1	-0.6	-0.2
Age started oral contraceptive pill	3.9	4.9	6.6	1.7	2.2	2.4	2.6	-1.8	-2.5
Diastolic blood pressure, automated reading	0.3	1.0	2.6	-0.4	1.6	1.4	1.1	0.4	-0.4
Ever depressed for a whole week	0.1	0.1	0.4	0.5	0.1	-0.1	-0.1	0.6	0.5
Unable to work because of sickness or disability	1.7	2.2	3.1	-1.1	-1.5	-1.6	-1.8	1.1	1.7
Commuting to job workplace: Cycle	2.3	2.7	5.3	2.3	-1.5	-1.3	0.4	-2.3	-1.3
Myopia	0.8	1.1	2.6	-0.7	-0.4	-0.5	-1.1	1.6	1.4
Vascular/heart problems diagnosed by doctor	0.4	1.1	3.6	0.9	-0.7	-0.2	0.4	-1.9	-1.3
Cholesterol lowering medication	0.4	0.6	1.2	1.0	0.7	0.6	1.1	-0.4	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.6	-0.8	-0.6	-0.6	-0.3	-0.3	0.0
Pain experienced in last month	0.3	0.4	1.0	-0.4	-1.0	-0.9	-0.8	-0.2	0.3
Supplements: Calcium	0.3	0.4	0.7	0.7	-0.8	-0.9	-0.2	-0.5	-0.0
Basal cell carcinoma (self-reported)	0.4	0.5	1.3	-0.9	-0.3	-0.2	0.1	-1.1	-0.8
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.6	1.3	0.9	0.8	0.8	0.2	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.0	0.1	0.0	0.0	-0.0	0.2	0.1
Heart disease (siblings)	1.2	1.5	3.6	0.9	0.2	0.5	1.1	-1.9	-1.7
Alcohol drinker status: Previous	0.4	0.5	2.3	1.5	0.4	0.3	0.7	-0.0	-0.2
Pack years of smoking	0.4	0.6	1.6	-1.3	1.0	0.9	0.3	0.4	-0.0
Impedance of whole body	0.7	3.7	7.7	2.6	-0.2	0.3	1.6	-2.8	-2.3
Leg fat mass (left)	0.3	1.2	2.9	-1.7	1.0	0.6	-0.1	1.4	0.8
Arm predicted mass (left)	1.6	8.0	19.8	-3.3	0.6	0.1	-2.0	4.5	3.5