TWAS hub - AFF1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1043	0.0367	1.2e-04	0.062	NA	0.050	NA	0.058	1.3e-05	NA	8.0e-05	NA	2.4e-05
2	GTEx	Brain Cerebellar Hemisphere	0.5180	0.0920	1.9e-08	0.137	NA	0.269	NA	0.242	2.3e-04	NA	1.4e-07	NA	6.8e-07
3	GTEx	Brain Cerebellum	0.2980	0.0860	9.1e-06	0.090	NA	0.261	NA	0.215	1.3e-03	NA	2.5e-08	NA	5.6e-07
4	GTEx	Cells Transformed fibroblasts	0.1130	0.0430	4.4e-03	0.000	NA	0.007	NA	0.013	2.9e-01	NA	9.3e-02	NA	3.6e-02
5	GTEx	Esophagus Muscularis	0.1110	0.0370	1.4e-04	0.087	NA	0.085	NA	0.099	5.9e-06	NA	7.3e-06	NA	1.3e-06
6	METSIM	Adipose	0.0590	0.0209	2.2e-07	0.048	0.052	0.055	0.051	0.056	1.1e-07	3.1e-08	1.3e-08	4.3e-08	8.1e-09
7	NTR	Blood	0.0209	0.0104	7.3e-03	0.003	0.006	0.001	0.006	0.001	3.6e-02	5.0e-03	1.1e-01	3.7e-03	9.4e-02
8	TCGA	Stomach Adenocarcinoma	0.0920	0.0440	2.1e-03	0.025	0.029	0.031	NA	0.030	5.8e-03	3.4e-03	2.7e-03	NA	2.9e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8
Triglycerides	12.1	19.8	37.4	-5.9	-5.1	-5.9	-0.7	-4.9	-6.1	0.4	-0.6
HDL Cholesterol	8.7	14.4	29.8	4.5	4.4	5.5	0.3	4.6	4.9	-1.3	0.3
Headache pain in last month	8.5	14.6	27.4	-5.2	-4.7	-4.8	-2.7	-3.5	-3.0	-2.4	-3.2
Blood Red Count	5.8	55.9	139.2	9.4	7.2	11.1	-0.8	11.8	6.2	-1.9	1.2
Hypothyroidism (self reported)	5.6	12.8	36.8	-3.8	-3.1	-4.2	-0.2	-6.1	-2.2	4.2	0.5
Migraine (self-reported)	4.6	5.7	15.7	-4.0	-2.0	-2.2	-2.6	-1.5	-2.1	-2.3	-1.6
Hypothyroidism/myxoedema (self-reported)	4.1	8.0	21.2	-3.7	-2.4	-3.2	-0.8	-4.6	-2.7	2.4	-0.1
Medication: Atorvastatin	4.0	4.9	14.7	-2.8	-1.7	-2.7	0.9	-2.4	-3.8	0.5	-0.2
Heel T-Score	3.9	31.3	116.6	-6.8	-4.4	-4.3	0.7	-5.3	-10.8	-3.9	2.2
Pulse wave Arterial Stiffness index	3.8	4.5	10.0	2.4	3.2	3.0	0.6	2.8	1.4	-0.5	0.6
Pulse wave peak to peak time	3.8	4.4	9.6	-2.2	-3.0	-3.1	-0.5	-3.0	-1.2	0.9	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	3.6	8.3	21.6	-3.9	-2.5	-1.8	0.0	-3.0	-4.7	-1.6	2.9
Lung FVC	3.5	17.7	39.6	-6.3	-4.0	-5.1	-2.5	-4.7	-4.3	-2.2	-3.0
Heel bone mineral density (BMD) T-score, automated (left)	3.4	7.8	21.9	-3.8	-2.7	-1.9	-0.2	-2.5	-4.7	-1.1	2.6
Illness, injury, bereavement, stress in last 2 years	3.4	4.2	8.1	2.5	2.8	2.6	0.6	2.4	1.9	-1.2	0.7
LDL Cholesterol	3.0	4.7	10.2	-2.7	-1.6	-3.2	-1.3	-2.5	-2.3	-1.1	-1.7
Medication: Levothyroxine sodium	2.9	4.9	14.4	-3.0	-1.4	-2.4	-1.0	-3.8	-1.7	2.2	-0.3
Gout (self-reported)	2.9	4.0	10.6	-2.4	-1.7	-2.7	0.7	-3.2	-1.6	0.9	1.4
Verbal and Numeric Reasoning (VNR)	2.8	6.7	11.5	3.4	3.0	3.1	2.8	1.4	0.9	2.3	2.9
Number of children fathered	2.8	3.1	7.5	-2.2	-1.6	-2.7	0.4	-2.5	-1.9	0.4	-0.2
Qualifications: NVQ or HND or HNC or equivalent	2.8	3.3	7.9	-2.1	-2.8	-2.0	-0.7	-1.3	-2.8	0.6	-0.6
Breast Cancer	2.6	6.3	13.7	3.7	2.1	2.8	1.7	2.5	2.7	1.9	2.0
Primary Biliary Cirrhosis	2.6	3.6	8.3	-2.2	-1.5	-2.7	-1.6	-2.9	1.2	0.0	-1.6
Body Mass Index (BMI) (2010)	2.5	3.4	7.4	-2.0	-1.9	-2.7	-1.4	-1.9	-1.4	1.4	-1.7
Impedance of arm (right)	2.5	11.8	28.3	3.9	5.3	3.7	0.6	2.7	4.9	-2.3	-0.1
Age at last live birth	2.4	3.5	9.2	1.0	3.0	2.7	0.3	2.7	0.5	-1.6	0.1
Medication: Omeprazole	2.1	2.5	6.7	-2.1	-2.0	-2.6	-0.3	-1.8	-1.2	0.3	-0.4
Cholesterol lowering medication	2.1	3.1	6.1	-2.1	-2.0	-2.1	0.1	-2.5	-2.2	-1.1	-0.2
Intelligence (Savage-Jansen 2018)	2.0	6.1	10.8	3.1	3.3	2.8	2.9	1.0	0.7	1.7	2.7
Major Depression (MDD)	2.0	2.4	7.3	2.1	1.1	1.9	0.1	1.5	2.7	0.1	-0.3
Suffer from ‘nerves’	2.0	3.1	6.2	-2.0	-1.5	-2.3	1.2	-2.1	-2.5	0.7	0.5
Impedance of arm (left)	1.9	9.0	23.2	3.3	4.8	3.3	0.1	2.0	4.2	-2.3	-0.7
Diastolic blood pressure, automated reading	1.9	6.0	16.4	2.3	2.1	3.1	0.2	4.0	2.5	-2.2	0.8
Schizophrenia vs Biploar Disorder	1.8	2.4	5.3	-1.6	-1.4	-1.7	-0.6	-2.3	0.7	0.8	-2.2
Health satisfaction	1.8	2.4	5.3	-2.0	-2.3	-1.9	0.8	-1.2	-1.9	-0.0	1.0
Tinnitus: Yes, now most or all of the time	1.8	2.1	3.7	-1.2	-1.9	-1.7	0.5	-1.8	-1.9	0.9	0.9
Unable to work because of sickness or disability	1.8	2.3	6.6	-1.3	-2.6	-1.0	-2.0	0.6	1.2	-0.4	-1.8
Neuroticism (2016)	1.7	2.4	6.7	0.2	-0.5	-0.6	1.9	0.1	-1.8	2.3	2.6
Had menopause	1.7	2.1	4.5	1.9	1.3	1.8	0.6	1.9	2.1	0.2	0.3
Mouth/teeth dental problems	1.7	2.6	6.2	1.2	1.6	2.3	-0.4	2.5	0.2	-2.1	0.4
Pulse rate	1.7	2.9	11.3	0.9	0.8	1.9	1.1	3.4	-1.1	-1.6	1.4
Lung cancer (father)	1.7	2.0	6.9	-1.9	-1.5	-1.0	-0.3	-0.7	-2.6	-1.2	-0.2
Loud music exposure frequency	1.7	1.9	6.7	-0.2	-0.7	-1.7	0.9	-1.7	-0.9	2.6	0.5
Risk taking	1.7	2.4	5.2	-1.0	-1.8	-2.3	-0.9	-1.9	1.4	-0.4	-1.8
Mean Putamen Volume	1.6	1.8	4.6	-1.1	-2.1	-2.0	-0.2	-1.6	-1.1	0.8	-0.5
Number of incorrect matches in round	1.6	2.6	5.1	-0.5	-1.6	-0.2	-2.2	0.9	2.0	-1.8	-2.3
Exposure to tobacco smoke at home	1.6	1.8	4.4	-1.5	-2.1	-1.9	-0.9	-1.2	-0.7	-0.3	-1.0
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	5.3	-2.1	-1.2	-2.3	-0.5	-1.7	-0.6	-0.0	-1.4
Illnesses of siblings: Diabetes	1.6	2.0	5.0	1.1	1.1	1.3	-0.6	1.4	2.2	-1.5	-1.5
Miserableness	1.6	2.7	7.1	1.9	1.1	2.7	1.1	1.5	1.2	1.5	1.6
Pain type(s) experienced in last month: Hip pain	1.6	2.0	6.9	-0.0	-2.6	-1.6	1.4	-0.2	-1.2	0.7	1.5
High cholesterol (Self-reported)	1.6	2.9	7.1	-1.3	-1.3	-1.3	2.3	-0.8	-2.7	-1.4	1.6
Ulcerative Colitis	1.5	2.1	4.5	0.5	1.6	0.7	-0.7	1.3	2.1	-1.7	-2.0
Financial difficulties in last 2 years	1.5	2.1	5.6	-1.6	-2.4	-1.2	-1.7	-0.6	-0.4	-0.3	-1.9
Time employed in main current job	1.5	1.7	4.6	-0.1	-0.5	-0.2	-1.5	0.8	1.3	-2.1	-2.1
Number of live births	1.5	2.1	7.7	0.5	1.1	0.9	2.1	-0.1	-0.4	1.5	2.8
Knee pain experienced in last month	1.5	2.3	6.7	0.3	-0.1	0.1	2.0	-0.2	-2.0	1.9	2.6
Blood White Count	1.4	10.1	25.5	-3.7	-3.4	-5.0	-0.3	-4.3	-3.2	0.9	-0.5
Taking other prescription medications	1.4	2.2	4.1	-1.7	-2.0	-1.5	0.3	-1.8	-1.6	1.2	0.7
Fluid intelligence score	1.4	3.0	6.0	2.0	2.4	2.2	1.4	0.5	1.4	1.6	1.4
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	2.8	-0.3	-0.9	-1.3	1.5	-1.5	-1.7	1.6	0.4
Medication: Ventolin 100micrograms inhaler	1.4	1.8	6.3	1.3	0.6	0.4	2.5	-0.1	-0.6	1.1	2.0
Alcohol intake frequency.	1.4	3.3	8.4	-1.9	-2.5	-2.9	-0.3	-2.1	-0.9	1.4	-0.9
Commuting to job workplace: Walk	1.4	1.5	3.8	1.2	1.4	2.0	-0.3	1.5	1.2	0.9	-0.2
Mouth/teeth dental problems: Mouth ulcers	1.4	2.3	6.1	-1.1	-1.9	-1.8	0.5	-1.4	-2.5	1.3	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	3.1	8.6	-2.0	-2.1	-2.0	0.6	-1.7	-2.9	0.6	0.1
Financial situation satisfaction	1.4	1.7	3.4	-1.5	-1.8	-1.5	-0.8	-0.6	-1.5	-1.0	-1.3
Coronary Artery Disease (CAD)	1.3	1.5	4.0	-1.6	-2.0	-1.7	-0.3	-1.2	-0.1	-0.9	-0.8
Serious illness, injury or assault to yourself	1.3	1.6	3.5	-1.9	-1.6	-1.1	-1.2	-0.7	-1.1	-1.0	-1.1
Hearing difficulty/problems with background noise	1.3	2.2	5.3	2.3	-0.2	0.5	1.7	-0.3	2.2	1.6	1.0
Pulse wave reflection index	1.3	1.6	4.2	1.6	1.9	2.0	-0.3	0.8	1.3	0.1	0.1
Age at first live birth	1.3	2.3	4.9	1.2	2.2	1.9	0.2	2.0	0.7	-1.7	-0.6
Medication: Allopurinol	1.3	1.7	6.8	-1.3	-0.3	-1.6	0.4	-2.6	-0.7	0.8	1.2
Mineral and other dietary supplements	1.3	1.7	4.4	-1.3	0.0	-0.6	-1.8	0.2	-0.5	-1.9	-2.1
Basal cell carcinoma (self-reported)	1.3	1.5	3.6	-0.3	-1.9	-1.3	0.8	-1.0	-0.5	1.9	1.2
Deep venous thrombosis (DVT) (self-reported)	1.3	1.6	3.9	1.9	1.4	1.2	-0.0	1.0	2.0	1.0	-0.0
Hayfever, allergic rhinitis or eczema	1.2	2.6	6.4	-0.9	-1.2	-0.9	1.7	-1.5	-1.7	1.8	2.5
Waist circumference	1.2	4.4	11.0	-1.7	-3.3	-2.9	0.2	-1.9	-2.7	1.2	-0.6
Had other major operations	1.2	1.5	3.2	1.3	0.1	1.8	1.3	1.7	0.1	1.2	1.1
Medication: Lansoprazole	1.2	1.4	3.1	-0.5	-0.5	-0.5	1.8	-0.7	-1.6	1.6	1.4
Length of working week for main job	1.2	1.4	2.5	0.4	-0.9	-1.4	1.2	-1.5	-0.8	1.2	1.6
Blood clot in the leg (DVT)	1.2	1.6	4.0	1.9	1.4	1.3	-0.1	0.8	2.0	0.8	0.1
Medication: Paracetamol	1.2	1.9	4.2	-1.9	-2.0	-1.3	-0.5	-0.3	-2.1	-1.2	-0.7
Qualifications: College or University degree	1.2	3.7	6.0	2.3	2.4	2.2	1.8	1.2	1.8	0.5	2.4
Average weekly red wine intake	1.2	1.8	4.0	2.0	2.0	1.6	1.0	0.7	1.6	-0.3	0.3
Number of operations (self-reported)	1.2	1.9	9.1	1.0	-1.4	-0.3	1.3	0.3	-0.2	3.0	0.9
Impedance of whole body	1.2	6.0	18.0	1.8	4.2	2.1	-0.1	0.7	3.3	-3.2	-0.4
Number of treatments/medications taken	1.1	2.1	4.8	-2.1	-1.4	-1.9	-0.2	-2.2	-1.3	-0.3	-0.2
Sensitivity / hurt feelings	1.1	1.9	3.7	-1.5	-1.4	-1.6	0.0	-1.4	-1.9	1.5	1.1
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	4.8	-0.2	-0.7	-1.3	0.9	-1.2	-1.1	2.2	1.1
Severe depression (siblings)	1.1	1.2	3.6	-0.6	-0.7	-0.2	-1.9	0.1	1.7	0.6	-1.5
Alcohol intake versus 10 years previously	1.1	1.6	4.9	-1.1	0.1	-0.9	-1.8	-1.1	1.2	-0.3	-2.2
Worrier / anxious feelings	1.1	2.0	5.4	0.6	0.1	0.7	1.8	1.9	-2.3	0.5	1.7
Medication: Cholesterol lowering	1.1	1.6	4.9	-0.9	-0.0	-0.4	1.8	0.4	-2.2	0.3	1.9
Prospective memory result	1.1	1.3	3.3	-1.8	0.1	-0.7	-1.6	-1.0	-0.7	-1.4	-0.7
Angina (self-reported)	1.1	1.5	4.0	0.8	0.2	1.0	1.8	1.1	2.0	-0.6	1.1
Loneliness, isolation	1.1	1.5	3.6	-1.0	-1.5	-1.4	0.8	-1.2	-1.0	1.9	-0.1
Ever taken oral contraceptive pill	1.1	1.2	4.3	0.6	0.5	-0.2	1.7	-0.7	-0.5	2.1	0.9
Leg fat percentage (left)	1.1	4.1	8.1	-2.9	-2.7	-2.6	-0.6	-1.9	-1.7	-1.3	-1.2
Bipolar Disorder (2011)	1.0	0.9	1.8	1.0	0.6	1.4	0.7	1.3	0.3	0.4	1.4
Type 2 Diabetes (T2D) (2012)	1.0	1.1	2.8	1.7	0.6	1.2	1.1	1.6	-0.3	-0.6	0.5
Systolic Blood Pressure	1.0	4.9	10.4	0.6	3.0	2.6	0.7	3.2	0.9	-3.0	1.4
Impedance of leg (right)	1.0	4.6	14.3	0.7	3.8	1.5	-0.1	-0.2	3.0	-3.3	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	3.2	-1.7	-1.0	-1.8	-0.3	-1.5	-0.4	0.2	-1.0
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.7	0.4	-1.0	0.7	-1.4	1.4	0.8	0.2	-1.6
Body mass index (BMI)	1.0	4.3	13.1	-2.3	-3.6	-2.5	-0.1	-1.2	-2.7	0.8	-0.4
Alcohol usually taken with meals	1.0	1.6	4.3	2.1	1.6	1.4	0.5	0.7	1.5	0.8	0.7
Heart attack	1.0	1.3	4.0	0.3	-0.8	-0.2	1.4	-0.7	0.8	2.0	1.6
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.9	-0.7	-0.9	-1.7	-0.2	-1.4	0.2	1.7	-0.9
Arm predicted mass (right)	1.0	5.3	19.5	-0.5	-3.0	-2.0	0.8	-2.2	-2.0	4.4	0.7
Breast cancer (self-reported)	1.0	1.1	3.0	-1.7	-1.0	-1.1	-1.3	-0.5	-1.2	-0.2	-0.9
Age started oral contraceptive pill	1.0	1.3	3.5	-0.3	-1.0	-0.7	1.9	-1.1	-0.5	1.8	0.8
Commuting to job workplace: Cycle	1.0	1.2	6.0	0.9	0.2	0.5	1.0	-0.6	-0.5	2.4	0.9
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.7	-1.1	-1.6	-1.6	0.4	-1.2	-1.0	0.5	0.3
BMI	0.9	5.0	12.9	-2.3	-3.6	-3.1	-0.1	-1.6	-2.9	0.7	-0.0
Waist Hip Ratio (WHR)	0.9	4.1	7.4	-1.9	-1.9	-2.1	-1.2	-1.6	-2.7	-2.6	-1.6
Angina	0.9	1.2	3.3	0.8	-0.1	0.6	1.8	1.0	1.7	-0.4	1.1
Age when periods started (menarche)	0.9	2.0	5.5	-1.4	-1.6	-2.3	0.4	-1.6	-1.7	0.2	-0.6
Forced expiratory volume in 1-second (FEV1)	0.9	2.9	7.8	-2.0	-0.9	-2.2	-0.4	-2.8	-2.1	1.1	-0.6
Breastfed as a baby	0.9	1.2	2.6	-0.6	-0.8	-0.5	-1.6	-1.0	1.4	-0.5	-1.5
Tense / ‘highly strung’	0.9	1.5	6.1	-1.1	0.2	-0.4	-1.3	-0.1	0.5	-1.6	-2.5
Hair/balding pattern: Pattern 4	0.9	2.2	5.5	1.5	-0.2	1.2	1.6	0.7	0.0	2.4	2.2
Arm fat-free mass (right)	0.9	4.6	19.9	-0.2	-2.8	-1.6	1.0	-1.6	-1.6	4.5	0.8
Comparative body size at age 10	0.9	2.5	8.1	0.7	0.2	1.0	1.4	1.7	-0.7	2.8	2.3
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	3.9	0.7	2.0	1.0	-0.5	-0.2	1.5	0.3	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	3.1	-1.3	-1.8	-0.9	-1.6	-0.0	0.4	-0.2	-0.4
Comparative height size at age 10	0.9	4.7	19.3	2.5	0.9	0.9	2.4	-0.2	0.5	4.4	2.1
Leg pain on walking	0.9	1.2	4.1	0.5	0.8	1.1	1.0	2.0	-0.7	-1.1	0.6
Supplements: Vitamin C	0.9	1.1	2.2	1.2	-0.1	1.4	0.6	1.4	1.5	-0.9	0.3
Ever had bowel cancer screening	0.9	1.1	3.6	-1.1	-0.9	-1.0	1.0	-0.7	-1.9	-0.1	0.7
Back pain experienced in last month	0.9	1.2	2.4	0.3	-1.4	-0.1	1.5	0.6	-1.5	1.2	1.3
Supplements: Fish oil (including cod liver oil)	0.9	1.2	3.0	1.3	-0.4	1.0	1.5	0.2	0.2	1.3	1.7
Arm fat-free mass (left)	0.9	4.4	18.7	-0.2	-2.7	-1.6	1.2	-1.5	-1.6	4.3	1.0
Pack years of smoking	0.9	1.3	5.6	-0.9	-0.0	-0.2	-1.7	0.0	-0.8	-0.5	-2.4
Arm predicted mass (left)	0.9	4.5	18.4	-0.4	-2.9	-1.6	0.9	-1.4	-1.7	4.3	1.0
Smoking Status	0.8	1.8	4.7	-1.1	-0.6	-1.4	-1.3	-1.9	0.5	-1.1	-2.2
Allergy or Eczema	0.8	2.0	4.7	-1.4	-1.0	-0.7	1.2	-1.5	-1.7	1.1	2.2
Hearing difficulty/problems: Yes	0.8	1.3	4.9	0.9	-1.4	-0.3	1.3	0.3	-0.1	2.2	0.8
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	1.8	-0.6	-0.2	-1.1	0.1	-1.3	-1.1	1.3	-0.6
Medication: Co-codamol	0.8	0.9	3.2	0.0	-1.6	-0.7	0.3	-0.8	0.1	1.8	0.8
Current tobacco smoking	0.8	1.3	3.2	-1.2	-0.7	-0.6	-1.8	-0.9	0.7	-1.2	-1.6
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.6	-0.6	-1.3	-0.9	0.5	-1.1	-1.2	0.6	1.1
Multivitamins +/- minerals	0.8	1.0	3.4	1.0	0.5	0.7	1.4	-0.1	-0.2	0.8	1.8
Supplements: Glucosamine	0.8	1.0	2.7	1.1	0.3	0.9	1.3	0.5	0.1	1.1	1.6
Impedance of leg (left)	0.8	4.0	14.5	0.0	3.2	0.9	-0.4	-0.7	2.4	-3.8	-0.3
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	1.8	1.0	0.6	1.3	0.7	1.2	1.3	0.6	0.1
Qualifications: None of the above	0.8	1.6	4.5	-2.1	-1.5	-1.5	-1.3	-1.2	-0.5	-0.4	-0.8
Qualifications: A levels/AS levels or equivalent	0.8	1.9	6.1	2.5	1.2	2.1	0.8	0.9	1.0	0.8	0.4
Leg fat percentage (right)	0.8	2.9	5.9	-2.4	-2.4	-2.2	-0.4	-1.7	-1.2	-1.1	-1.0
Had major operations	0.8	0.9	2.9	0.8	-0.6	0.1	-0.5	0.3	1.6	1.7	-0.6
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.6	-1.1	-0.9	-1.4	-0.5	-1.6	0.5	-0.7	0.3
Illnesses of father: High blood pressure	0.8	1.0	1.9	1.4	-0.4	-0.2	1.2	0.3	1.4	1.2	0.9
Heart attack/myocardial infarction (self-reported)	0.8	1.0	3.0	0.3	-0.7	-0.2	1.2	-0.8	0.7	1.7	1.3
Heart disease (siblings)	0.8	1.0	4.3	-0.7	-2.1	-1.3	0.5	-0.6	-0.0	0.9	0.4
Neuroticism (Nagel 2018)	0.7	1.7	5.7	-1.3	-1.5	-1.6	0.5	-0.7	-2.4	0.9	-0.1
Schizophrenia (2018)	0.7	1.5	4.6	-1.6	0.2	-0.2	-1.6	-0.9	2.1	-0.1	-1.3
Ovarian Cancer	0.7	0.9	3.5	0.4	1.9	1.0	0.2	0.7	-0.5	-1.1	0.7
Prostate Cancer	0.7	1.0	3.9	-0.2	-0.3	-0.5	2.0	-0.2	-1.6	0.8	0.9
Height	0.7	12.8	47.7	4.0	3.6	2.5	1.6	-0.1	4.0	6.9	0.7
Lung FEV1/FVC ratio	0.7	3.6	8.8	-0.2	-1.2	-1.9	3.0	-1.8	-1.8	0.6	2.8
Frequency of depressed mood in last 2 weeks	0.7	0.9	5.6	0.1	0.0	-0.0	0.8	-0.2	0.8	2.4	0.6
Ever used hormone-replacement therapy (HRT)	0.7	0.9	3.2	1.2	-0.7	0.3	1.1	0.6	0.5	1.8	0.3
Vitamin and mineral supplements	0.7	0.9	3.2	-1.0	-0.2	-0.5	-1.6	0.2	-0.5	-0.5	-1.8
Supplements: Zinc	0.7	0.8	2.4	-0.0	-1.0	-0.8	0.0	-1.6	0.5	1.3	-0.6
Leg fat-free mass (left)	0.7	3.7	21.9	1.3	-1.7	-0.4	1.2	0.0	-0.9	4.7	0.8
Leg predicted mass (left)	0.7	3.6	21.4	1.3	-1.8	-0.5	1.1	0.0	-0.9	4.6	0.7
Pain all over the body in last month	0.7	0.8	3.0	1.1	-0.4	0.1	0.7	-0.8	0.7	1.7	0.4
Trunk fat-free mass	0.7	3.9	23.2	0.8	-1.7	-0.6	1.2	-0.8	-0.7	4.8	1.1
Father’s age at death	0.7	0.9	2.5	0.6	0.5	0.1	0.6	-1.0	0.5	1.5	1.6
Falls in the last year	0.7	1.0	3.8	-1.4	-1.0	-0.0	1.0	-0.1	-2.0	-0.3	0.4
Trunk predicted mass	0.7	3.8	23.1	0.8	-1.6	-0.6	1.2	-0.7	-0.7	4.8	1.1
Standing height	0.7	7.1	19.8	3.8	2.7	2.1	1.7	0.3	2.3	4.5	1.4
Medication for pain relief, constipation, heartburn	0.7	1.3	4.4	1.2	1.6	0.7	-0.8	-0.0	2.1	0.6	-0.4
Medication: Ibuprofen	0.7	0.9	3.3	-0.6	-1.6	-0.4	0.0	0.0	-0.7	-1.8	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	3.7	1.9	0.9	1.0	1.3	0.9	0.3	1.5	0.8
Whole body fat-free mass	0.7	3.9	22.8	0.8	-1.9	-0.7	1.1	-0.6	-0.9	4.8	0.9
Long-standing illness, disability or infirmity	0.7	1.1	3.4	1.1	0.6	0.5	1.5	0.4	0.7	1.8	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.1	0.9	1.5	1.0	0.5	0.2	1.2	0.6	0.4
Friendships satisfaction	0.7	0.9	1.9	1.3	0.0	1.0	1.4	1.1	0.7	0.9	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	1.8	1.1	-0.0	0.8	1.0	1.1	-0.4	0.9	1.3
Whole body water mass	0.7	4.1	23.9	0.8	-2.0	-0.8	1.2	-0.8	-1.0	4.9	1.0
Eye problems/disorders: Glaucoma	0.7	0.8	2.1	1.0	0.6	1.0	0.3	0.9	1.4	-0.6	0.9
Basal metabolic rate	0.7	3.8	20.5	0.5	-2.2	-1.1	1.1	-0.9	-1.2	4.5	0.8
Ever depressed for a whole week	0.7	0.8	2.3	0.8	0.3	0.7	0.7	0.5	1.5	1.5	-0.2
Myopia	0.7	1.0	1.8	-1.1	-0.7	-1.1	-1.2	0.1	-0.7	-1.3	-1.1
Supplements: Calcium	0.7	0.7	2.8	0.3	-0.0	-0.5	1.7	-0.8	-0.2	1.2	0.7
Leg fat mass (left)	0.7	2.6	7.2	-1.6	-2.7	-2.2	-0.0	-1.6	-1.6	1.0	-0.5
Alzheimer’s Disease (in father)	0.6	0.7	1.2	-1.1	0.8	-0.0	-0.9	-1.1	-0.0	-1.0	-0.8
Reaction Time	0.6	1.2	4.6	-0.4	-0.3	-0.6	-1.0	0.5	-0.0	-1.7	-2.2
Age at First Birth	0.6	0.9	2.8	0.9	0.5	0.1	1.7	-0.6	-0.2	1.0	1.3
Neuroticism	0.6	1.5	5.6	-1.5	-0.8	-1.4	0.6	-0.8	-2.4	0.6	-0.1
Average weekly spirits intake	0.6	0.8	2.0	-0.6	-1.2	-0.9	-0.5	-0.7	-0.7	0.6	-1.4
Systolic blood pressure, automated reading	0.6	1.6	5.3	-0.3	0.8	1.0	0.9	1.8	-0.6	-2.3	1.2
Diabetes (father)	0.6	0.8	1.8	1.1	1.1	0.0	-0.7	-0.5	1.3	0.5	-1.0
Diabetes (mother)	0.6	0.8	2.1	0.2	-1.1	0.3	-0.9	-0.4	1.2	0.4	-1.5
Pack years adult smoking proportion	0.6	1.0	4.1	-0.6	0.0	0.0	-1.6	0.3	-0.6	-0.5	-2.0
Average weekly fortified wine intake	0.6	0.7	2.3	0.9	0.3	0.8	0.9	0.5	0.1	1.5	1.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.7	-0.9	-0.3	-0.1	-1.6	-0.1	0.3	-0.9	-1.2
Chronic bronchitis/emphysema (father)	0.6	0.7	2.7	1.3	0.4	0.5	1.6	0.1	0.5	0.6	0.8
Nervous feelings	0.6	1.1	2.3	-1.2	-0.9	-1.3	0.4	-1.2	-1.5	0.8	-0.1
Medication: Ramipril	0.6	0.7	2.6	-0.8	-0.4	-0.7	0.7	-1.6	-0.8	0.2	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	4.2	-1.2	-1.1	-1.8	-0.1	-2.0	-1.6	1.3	-0.5
Arm fat mass (right)	0.6	2.4	7.7	-1.2	-2.8	-1.9	0.1	-1.1	-1.8	1.4	-0.4
Birth weight of first child	0.6	1.0	4.5	0.9	-1.1	0.7	0.5	0.5	-0.8	2.1	-0.4
Peak expiratory flow (PEF)	0.6	1.5	7.9	-1.4	-0.3	-0.9	-0.1	-0.9	-2.8	-0.1	-0.5
Worry too long after embarrassment	0.6	1.0	2.7	-1.1	-1.1	-1.2	-0.2	-1.0	-1.6	0.1	-0.1
Mean time to correctly identify matches	0.6	1.1	4.7	-0.2	0.0	-0.4	-0.9	0.6	0.3	-1.6	-2.2
Leg fat mass (right)	0.6	2.5	7.3	-1.6	-2.7	-2.2	-0.0	-1.4	-1.4	1.0	-0.7
Smoking status: Previous	0.6	0.9	2.4	-0.6	-0.3	-1.3	-0.8	-1.5	0.7	0.2	-1.3
Leg fat-free mass (right)	0.6	3.3	19.0	1.0	-1.9	-0.6	0.8	-0.0	-1.2	4.4	0.4
Medication: Gliclazide	0.6	0.7	2.2	1.0	0.4	1.1	-0.1	1.5	0.9	0.0	-0.4
Leg predicted mass (right)	0.6	3.4	19.7	1.0	-1.9	-0.7	0.9	-0.2	-1.2	4.4	0.5
Arm fat mass (left)	0.6	2.6	7.8	-1.2	-2.8	-2.0	0.2	-1.3	-1.8	1.6	-0.5
Average weekly champagne plus white wine intake	0.6	0.8	3.7	1.0	0.1	0.7	1.0	0.1	-0.1	0.1	1.9
Medication: Paracetamol	0.6	0.9	1.7	-1.1	-1.2	-0.8	-0.5	0.1	-1.3	-1.2	-0.7
Irritability	0.6	1.0	2.2	0.6	1.4	0.6	1.1	-0.3	-0.8	1.5	0.9
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.8	1.3	1.3	1.4	-0.0	0.7	0.4	-0.3	0.4
HbA1C	0.5	0.6	2.0	0.1	1.4	0.6	0.9	-0.7	-0.4	-0.2	0.8
Blood Platelet Count	0.5	6.2	18.7	1.1	-0.9	1.6	2.4	4.3	-2.6	-3.6	1.0
Cardiovascular Disease	0.5	1.5	4.0	-0.3	2.0	0.8	1.1	0.4	0.6	-1.9	1.3
Medication: Metformin	0.5	0.7	1.9	1.4	-0.8	0.2	-0.4	1.3	0.6	0.1	-0.8
Townsend deprivation index at recruitment	0.5	0.7	3.5	-0.3	-1.9	-0.4	-0.9	-0.0	0.6	0.7	-0.8
Maternal smoking around birth	0.5	0.7	1.5	-1.2	-0.5	-1.0	-0.4	-0.8	-1.0	0.9	-0.2
Qualifications: CSEs or equivalent	0.5	0.6	2.3	-0.7	-1.0	-0.6	0.1	0.2	-1.5	-0.9	-0.1
Forced vital capacity (FVC)	0.5	2.0	6.2	-1.8	-0.0	-1.5	-0.8	-2.5	-1.4	1.0	-0.7
Medication: Simvastatin	0.5	0.7	1.9	-0.6	-0.5	-0.3	0.9	-0.4	-1.0	-0.8	1.4
Weight	0.5	2.5	8.5	-0.5	-2.3	-1.5	0.6	-1.1	-1.5	2.9	0.2
Noisy workplace	0.5	0.6	1.6	-0.9	-1.3	-0.9	-0.3	-1.1	-0.0	0.1	-0.0
Mouth/teeth dental problems: Dentures	0.5	0.8	2.3	0.5	-0.8	-0.1	0.3	-0.6	1.2	1.5	1.1
Depression (self-reported)	0.5	0.6	1.8	-0.8	-0.2	0.2	-1.0	0.4	0.7	-1.3	-1.1
Shortness of breath walking on level ground	0.5	0.6	1.7	-0.1	1.2	0.7	-0.8	0.5	1.3	-0.3	-0.6
Eye problems/disorders: None of the above	0.5	0.6	2.8	0.1	-0.9	-0.8	0.5	-0.1	-0.1	1.7	0.6
Medication: Seretide 50 evohaler	0.5	0.6	1.6	0.4	0.4	1.1	0.5	0.8	0.4	-0.7	-1.3
Overall health rating	0.5	1.1	4.1	-1.7	-2.0	-1.0	0.1	-0.4	-0.7	0.0	-0.2
Mood swings	0.5	0.9	3.0	0.4	-0.5	0.1	1.0	0.4	-1.7	1.4	0.3
Hearing aid user	0.5	0.6	1.8	0.5	-0.5	0.5	-0.9	1.4	0.7	0.3	-0.8
Medication: Lisinopril	0.5	0.6	1.3	-0.5	0.4	-0.3	0.2	-0.9	-1.2	-0.9	1.1
Bipolar Disorder (2018)	0.4	0.6	2.0	0.5	-0.5	0.5	0.1	1.4	0.3	-1.2	-0.1
Bipolar Disorder or Schizophrenia	0.4	1.0	3.4	-0.9	-0.2	0.1	-1.2	0.2	1.8	-0.9	-1.1
Depressed Affect (Nagel 2018)	0.4	0.8	2.9	-0.3	-0.9	-0.5	0.8	-0.2	-1.7	1.2	0.3
Depression (Nagel 2018)	0.4	0.5	2.5	-0.5	-0.1	-0.6	0.4	-0.9	0.2	1.6	0.2
Worry (Nagel 2018)	0.4	0.9	2.3	-1.2	-0.8	-1.1	0.2	0.0	-1.5	-0.5	-1.0
Crohns Disease (2017)	0.4	1.0	3.5	-1.1	-1.9	-1.1	0.8	-0.2	-1.0	0.4	0.1
Fasting Glucose	0.4	0.5	1.4	-0.5	-0.8	-0.8	-0.0	0.4	-1.2	-0.1	-0.7
Schizophrenia (2014)	0.4	0.9	2.3	-1.1	-0.0	-0.3	-0.6	-0.9	1.5	-0.5	-1.4
Relative age of first facial hair	0.4	0.9	4.9	-0.8	-0.5	-0.8	-0.2	-0.8	-2.2	-0.4	-0.4
Ever had hysterectomy (womb removed)	0.4	0.4	1.6	0.3	-1.3	0.3	0.7	0.7	-0.0	-0.1	0.5
Medication for hormone replacement therapy	0.4	0.4	2.8	0.6	0.2	-0.1	-0.1	0.0	1.7	0.4	-0.1
Fed-up feelings	0.4	0.7	3.1	-0.5	-0.3	0.4	0.3	0.2	-1.8	1.2	0.5
Medication: Atenolol	0.4	0.5	1.3	0.0	0.1	0.2	-0.7	0.6	1.1	-0.8	-1.1
Hair/balding pattern: Pattern 2	0.4	0.5	2.1	0.4	0.1	0.2	-0.6	1.1	0.2	-0.1	-1.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.6	0.3	1.2	0.3	0.2	-1.1	1.3	-0.1	0.3
Neuroticism score	0.4	0.8	2.5	-0.3	-0.3	-0.5	1.1	-0.4	-1.6	1.3	0.7
Hair/balding pattern: Pattern 3	0.4	0.6	1.7	0.3	1.2	0.4	0.7	-0.2	1.3	0.1	0.7
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.3	-0.9	-0.7	-0.3	-0.3	-1.1	-0.7	0.5	0.1
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.8	0.7	-0.2	0.1	-1.3	-0.0	1.1	-0.3	-1.3
Glaucoma (self-reported)	0.4	0.5	1.5	0.7	0.7	0.1	1.2	0.0	0.2	-0.2	1.2
Medication: Amlodipine	0.4	0.5	3.1	0.0	1.8	0.4	0.3	0.6	0.4	-0.4	-0.4
Birth weight	0.4	0.9	2.9	0.4	-1.4	-0.0	0.2	1.0	0.8	-0.2	-1.7
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.4	0.3	0.6	0.1	-1.2	0.6	-0.1	-0.6	-1.0
Body fat percentage	0.4	1.5	3.9	-1.3	-2.0	-1.7	0.1	-1.3	-1.2	-0.1	-0.8
Number of full brothers	0.4	0.5	1.3	-0.6	-0.8	-1.1	0.4	-1.1	-0.2	-0.0	-0.1
Wheeze or whistling in the chest in last year	0.4	0.7	2.0	0.2	-0.0	1.4	-1.1	0.8	0.4	-1.1	-0.4
Emphysema/chronic bronchitis	0.4	0.5	1.7	0.1	0.8	1.3	-0.5	1.0	0.4	-0.1	-0.2
Neck or shoulder pain in last month	0.4	0.5	1.7	-0.5	-0.9	0.1	-0.5	-0.3	1.1	-0.3	-1.3
Whole body fat mass	0.4	1.8	4.9	-0.9	-2.2	-1.7	0.3	-1.4	-1.3	1.4	-0.4
Pulse rate, automated reading	0.4	1.2	6.2	-0.4	-0.9	0.4	-0.5	2.5	-0.7	-1.0	0.0
Number of full sisters	0.4	0.5	2.1	1.0	0.0	0.5	0.1	0.5	1.5	-0.2	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.4	-0.5	-1.1	-1.2	0.4	-0.1	-0.6	0.4	-0.1
Arm fat percentage (left)	0.4	1.6	5.2	-1.3	-2.3	-1.6	-0.4	-0.7	-1.2	0.0	-1.2
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.1	0.4	0.9	-0.2	-0.8	-0.4	1.0	-0.1	-0.9
Medication for cholesterol	0.4	0.6	1.7	1.0	0.0	0.6	0.7	1.1	-0.1	1.3	0.2
Osteoarthritis (self-reported)	0.4	0.5	2.0	0.6	0.5	0.4	0.7	-0.4	1.4	0.5	0.4
Medication: Aspirin	0.4	0.5	2.5	0.5	1.0	0.4	1.6	-0.1	0.2	0.2	0.2
Smoking status: Current	0.4	0.6	1.2	-0.8	-0.3	-0.2	-1.1	-0.6	0.4	-1.1	-0.9
Alcohol drinker status: Never	0.4	0.5	1.4	0.2	0.4	0.6	-0.5	0.9	-0.3	-1.2	-0.7
Average weekly beer plus cider intake	0.4	0.6	2.1	-1.0	-0.6	-0.2	-0.8	-0.7	-1.4	-0.2	-0.5
Alzheimer’s Disease (in mother)	0.3	0.3	1.5	0.0	-1.2	-0.1	-0.6	-0.3	0.4	-0.5	0.5
Alzheimer’s Disease (including proxy)	0.3	0.4	1.4	-0.5	-0.1	0.1	-1.0	-1.2	0.5	-0.6	0.1
Blood Eosinophil Count	0.3	2.4	9.3	1.9	0.6	2.4	-0.2	3.0	0.3	-0.4	0.6
Chronotype (morning person)	0.3	0.7	1.7	-0.5	-0.4	-1.1	0.8	-0.4	-1.2	-0.4	1.3
Hand grip strength (left)	0.3	0.7	2.8	0.4	0.8	0.2	-0.8	0.1	1.0	1.7	0.7
High blood pressure	0.3	0.9	2.0	-0.0	1.4	1.4	0.5	0.5	0.6	-1.3	0.5
Stomach or abdominal pain in last month	0.3	0.3	1.0	-0.1	-1.0	-1.0	0.1	-0.5	0.0	0.0	-0.7
Sitting height	0.3	2.1	15.7	0.4	-0.5	-0.5	-0.2	-0.5	-0.6	4.0	0.4
Trunk fat mass	0.3	1.2	2.6	-0.2	-1.6	-1.3	0.8	-1.2	-1.0	1.6	-0.1
Allergy	0.3	0.7	2.0	0.0	0.4	-0.1	-0.9	0.3	0.5	-1.4	-1.4
Illnesses of siblings	0.3	0.4	1.5	-0.2	0.8	0.5	-0.6	-0.3	-1.2	0.3	0.3
Arm fat percentage (right)	0.3	1.4	5.2	-1.1	-2.3	-1.4	-0.3	-0.4	-1.0	-0.1	-1.1
Hip circumference	0.3	1.3	6.7	0.2	-1.2	-0.6	1.0	-0.2	-0.7	2.6	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.2	-0.5	-0.6	0.8	-0.6	1.1	0.9	0.3	-0.6
Asthma	0.3	0.6	2.3	0.8	0.4	1.5	-0.3	1.1	0.5	0.1	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.5	-0.1	-1.2	0.1	0.3	0.3	-0.5	-1.0	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.8	0.5	-0.8	0.8	0.0	1.3	0.1	0.2	-0.9
Exposure to tobacco smoke outside home	0.3	0.4	1.4	0.5	-0.5	0.5	-0.3	1.2	0.6	-0.7	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.0	-0.7	-1.0	-0.4	-0.4	-0.3	0.4	-1.0	-0.7
Chest pain or discomfort	0.3	0.4	1.9	-0.3	-0.0	1.4	0.0	0.8	-0.1	-0.8	-0.0
Medication: Aspirin	0.3	0.3	1.8	0.0	0.9	0.1	1.3	-0.3	-0.1	-0.3	0.2
Hypertension (Self-reported)	0.3	0.8	1.8	-0.4	1.3	1.2	0.5	0.3	0.2	-1.3	0.9
Illnesses of father: Heart disease	0.3	0.4	1.3	-0.1	0.7	-0.2	-0.8	-0.7	1.1	0.0	-0.4
Diabetes diagnosed by doctor	0.3	0.6	1.3	1.1	0.0	0.8	0.7	1.0	-0.4	0.8	0.7
Eye problems/disorders: Cataract	0.3	0.4	1.5	0.5	0.6	1.2	0.2	0.4	-0.5	-0.5	0.5
Asthma (self-reported)	0.3	0.5	2.1	0.9	0.3	1.4	-0.2	1.0	0.4	0.3	0.1
Illnesses of father: None of the above (group 1)	0.3	0.3	0.8	-0.7	-0.6	-0.0	-0.6	0.4	-0.9	-0.7	0.1
Guilty feelings	0.3	0.4	0.7	-0.8	-0.6	-0.9	-0.2	-0.1	-0.5	0.8	-0.8
Wears glasses or contact lenses	0.3	0.3	1.3	-0.6	0.0	-0.2	-0.0	0.1	-0.8	1.1	-0.6
Mother’s age at death	0.3	0.4	2.1	-0.8	-0.2	-0.1	0.1	-0.4	-1.5	0.2	-0.2
Medication: Blood pressure	0.3	0.5	1.3	-0.1	1.1	1.2	0.5	-0.4	-0.1	-0.4	1.0
Medication: Bendroflumethiazide	0.3	0.4	1.2	1.1	0.2	0.8	0.6	-0.4	0.7	0.5	0.6
Ever smoked	0.3	0.5	2.3	-0.2	-0.1	-0.6	-0.4	-0.8	0.6	0.0	-1.5
Fractured/broken bones in last 5 years	0.3	0.4	1.1	-0.3	0.7	0.7	-0.7	0.4	1.0	0.4	0.0
Pain experienced in last month	0.3	0.5	1.4	0.1	1.2	0.6	-0.4	0.4	0.9	-1.1	-0.4
Alcohol drinker status: Previous	0.3	0.4	1.5	-0.1	0.7	1.2	-0.1	0.8	0.4	-0.5	-0.3
Ulcerative Colitis (UC)	0.2	0.4	1.9	-0.2	0.6	-0.2	-0.0	0.0	0.8	-0.4	-1.4
Crohns Disease (2012)	0.2	0.3	1.9	0.0	-0.1	0.1	1.4	0.4	0.5	0.4	0.5
Lupus	0.2	0.3	1.3	-0.2	1.1	0.2	0.1	-0.7	0.2	-0.5	0.3
Respiratory disease	0.2	0.4	1.4	0.5	0.0	1.2	0.5	0.9	-0.1	-0.0	0.4
Tanning	0.2	1.9	6.1	-0.9	-0.3	-1.3	-2.1	-2.5	-0.2	0.8	-1.2
Trunk fat percentage	0.2	0.6	1.3	-0.4	-1.1	-1.1	0.6	-1.0	-0.9	0.4	-0.4
Hand grip strength (right)	0.2	0.6	1.2	0.2	1.1	0.8	-0.7	-0.1	0.6	1.1	0.8
Relative age voice broke	0.2	0.4	1.3	-0.0	0.9	0.6	0.6	-0.2	-1.1	-0.3	0.4
High blood pressure (mother)	0.2	0.3	0.9	0.4	1.0	0.1	0.5	-0.3	-0.7	-0.3	0.7
Past tobacco smoking	0.2	0.4	1.5	0.2	-0.2	0.7	0.3	1.0	-0.5	0.0	1.2
Happiness	0.2	0.3	1.2	-0.6	0.4	0.3	1.1	0.4	0.2	-0.3	0.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.1	0.5	0.6	0.2	0.4	0.5	-1.1	0.2	-0.6
High blood pressure (siblings)	0.2	0.3	1.7	0.1	-1.3	-0.5	0.3	0.1	0.1	-0.3	-0.3
Forced vital capacity (FVC), Best measure	0.2	0.7	2.2	-0.5	-0.2	-0.9	-0.6	-1.5	-0.6	1.2	-0.7
Family relationship satisfaction	0.2	0.3	0.5	0.5	0.7	0.7	0.7	0.4	0.3	-0.2	0.2
Qualifications: nursing, teaching	0.2	0.3	1.4	0.4	-0.4	-0.4	0.2	-0.6	-0.2	1.2	0.1
Osteoporosis (self-reported)	0.2	0.3	1.2	-0.1	-0.1	-0.2	0.6	0.1	-1.1	0.7	0.3
Number of self-reported non-cancer illnesses	0.2	0.3	0.7	0.1	0.9	0.8	-0.2	0.4	0.5	-0.8	0.4
Vascular/heart problems diagnosed by doctor	0.2	0.5	2.5	0.8	-0.7	-0.7	-0.5	0.0	-0.2	1.6	-0.1
Irritable Bowel Disease (IBD)	0.1	0.3	0.7	-0.5	-0.6	-0.6	0.7	0.2	0.0	-0.0	-0.9
Rheumatoid Arthritis	0.1	0.2	0.5	-0.4	0.4	0.2	-0.5	-0.2	0.2	0.3	0.7
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.4	0.6	-0.3	0.2	-0.3	0.5	0.2	0.1	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.9	-1.0	0.6	0.2	0.1	-0.1	-0.3	-0.0	-0.1
Diabetes (self-reported)	0.1	0.2	0.5	0.7	0.0	0.4	0.2	0.6	-0.5	0.4	0.4
Illnesses of mother	0.1	0.1	0.2	-0.1	-0.1	-0.0	0.3	-0.5	-0.4	0.3	0.3
Medication: Blood pressure	0.1	0.1	0.6	-0.8	0.3	-0.2	0.3	-0.3	-0.1	-0.1	0.3
Heart disease (mother)	0.1	0.2	0.5	0.3	-0.6	0.2	0.2	0.7	0.5	0.1	0.1
Commuting to job workplace: Public transport	0.1	0.1	0.3	-0.1	0.3	0.3	0.2	-0.5	-0.6	0.6	0.1
Hair Pigment	0.0	0.5	2.6	0.3	0.1	0.5	0.7	1.6	-0.1	0.7	-0.2

Hub : Genes

AFF1

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