Hub : Genes

HSD17B13

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.3220 0.0470 0.0e+00 0.279 0.266 0.273 0.288 0.274 5.4e-34 2.3e-32 2.8e-33 2.8e-35 2.4e-33
2 GTEx Adipose Subcutaneous 0.1780 0.0800 4.1e-03 0.009 NA 0.018 NA 0.001 5.6e-02 NA 1.2e-02 NA 2.4e-01
3 GTEx Adipose Visceral Omentum 0.1720 0.0630 2.8e-04 0.021 NA 0.046 NA 0.039 2.8e-02 NA 2.1e-03 NA 4.4e-03
4 GTEx Artery Tibial 0.2692 0.0586 7.7e-07 0.008 NA 0.076 NA 0.043 7.4e-02 NA 1.4e-06 NA 2.5e-04
5 GTEx Brain Cerebellar Hemisphere 0.3740 0.1010 1.2e-04 0.211 NA 0.114 NA 0.123 3.9e-06 NA 7.7e-04 NA 4.7e-04
6 GTEx Brain Cerebellum 0.2620 0.0860 2.2e-03 0.207 NA 0.044 NA 0.178 9.3e-07 NA 1.9e-02 NA 5.8e-06
7 GTEx Brain Cortex 0.2830 0.0870 1.9e-03 0.232 NA 0.258 NA 0.252 4.5e-07 NA 8.9e-08 NA 1.3e-07
8 GTEx Esophagus Muscularis 0.1180 0.0620 1.0e-02 0.043 NA -0.002 NA 0.021 1.2e-03 NA 4.5e-01 NA 1.9e-02
9 GTEx Lung 0.0665 0.0320 6.2e-03 0.009 NA 0.001 NA 0.003 6.6e-02 NA 2.8e-01 NA 1.8e-01
10 GTEx Nerve Tibial 0.4559 0.0624 7.4e-15 0.072 NA 0.218 NA 0.269 8.0e-06 NA 2.0e-15 NA 3.6e-19
11 GTEx Ovary 0.3420 0.1170 2.5e-03 0.188 NA 0.113 NA 0.101 2.2e-05 NA 1.1e-03 NA 1.9e-03
12 GTEx Skin Sun Exposed Lower leg 0.1130 0.0410 2.5e-04 0.093 NA 0.077 NA 0.083 4.4e-08 NA 5.9e-07 NA 2.2e-07
13 GTEx Spleen 0.2590 0.0960 1.3e-03 0.127 NA 0.155 NA 0.222 3.9e-04 NA 8.8e-05 NA 2.2e-06
14 GTEx Thyroid 0.2000 0.0530 6.8e-07 0.043 NA 0.136 NA 0.069 3.2e-04 NA 1.4e-10 NA 5.9e-06
15 GTEx Whole Blood 0.2490 0.0580 2.5e-10 0.117 NA 0.142 NA 0.108 6.9e-11 NA 5.3e-13 NA 3.5e-10
16 METSIM Adipose 0.2038 0.0482 1.8e-15 0.104 0.112 0.111 0.123 0.115 2.5e-15 2.2e-16 3.3e-16 7.3e-18 7.4e-17
17 NTR Blood 0.0404 0.0115 3.5e-09 0.041 0.033 0.036 0.043 0.039 3.5e-13 8.1e-11 7.4e-12 9.1e-14 1.1e-12
18 ROSMAP Brain Pre-frontal Cortex 0.4536 0.0436 0.0e+00 0.419 0.430 0.451 0.443 0.463 2.2e-58 1.7e-60 2.3e-64 9.7e-63 1.2e-66
19 YFS Blood 0.2406 0.0358 0.0e+00 0.193 0.179 0.192 0.199 0.195 7.1e-61 3.3e-56 9.4e-61 7.5e-63 1.3e-61
20 TCGA Breast Invasive Carcinoma 0.0410 0.0232 8.7e-04 0.003 0.006 0.005 NA 0.006 6.5e-02 1.8e-02 2.5e-02 NA 2.1e-02
21 TCGA Kidney Renal Papillary Cell Carcinoma 0.1120 0.0580 1.5e-03 0.007 0.065 0.048 NA 0.016 1.3e-01 1.3e-04 1.0e-03 NA 3.9e-02
22 TCGA Brain Lower Grade Glioma 0.0659 0.0290 5.0e-06 0.006 0.031 0.019 NA 0.017 6.9e-02 1.8e-04 2.7e-03 NA 4.3e-03
23 TCGA Lung Adenocarcinoma 0.0518 0.0233 1.7e-07 0.071 0.065 0.074 NA 0.051 1.1e-08 4.7e-08 5.4e-09 NA 1.2e-06
24 TCGA Thyroid Carcinoma 0.0350 0.0220 4.2e-03 0.008 0.021 0.006 NA 0.009 5.5e-02 3.2e-03 7.3e-02 NA 4.5e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
Bipolar Disorder (2018) 0.1 0.1 0.7 0.5 -0.1 -0.8 0.0 0.4 0.6 0.8 -0.3 0.4 0.4 0.4 -0.1 0.3 -0.2 -0.0 -0.4 0.4 0.4 0.3 -0.1 -0.0 0.3 -0.2 0.0
Bipolar Disorder or Schizophrenia 0.4 0.9 2.3 -1.0 0.8 1.0 -0.7 -1.5 -1.1 -0.6 0.1 0.4 -1.0 -1.1 0.0 -1.0 -1.0 -1.5 1.4 -1.4 -1.2 -1.1 0.2 -0.2 -1.2 0.2 -0.6
Depressed Affect (Nagel 2018) 0.6 1.3 4.6 0.3 -0.3 -1.5 1.5 1.2 0.4 1.1 0.1 0.7 2.1 1.6 0.7 2.0 -0.1 1.1 -0.6 0.5 1.1 0.4 0.0 0.3 2.0 0.9 1.8
Depression (Nagel 2018) 1.0 1.6 5.1 -2.1 0.7 -0.2 0.5 -1.5 -2.0 -1.6 -0.7 0.7 -0.0 -0.3 2.0 -0.2 -0.4 0.1 -0.8 -1.7 -1.3 -1.6 1.4 -0.3 -0.4 2.2 1.7
Intelligence (Savage-Jansen 2018) 0.6 1.8 8.8 -1.0 -1.6 -2.0 -0.2 0.0 -0.7 -0.5 -3.0 2.0 -0.2 -0.9 2.0 1.0 0.3 1.2 -2.2 -0.8 -1.0 -0.7 -0.8 -1.5 -0.2 1.6 1.8
Neuroticism (Nagel 2018) 0.2 0.4 2.4 -0.7 0.9 0.3 1.6 -0.0 -0.6 -0.0 0.6 -0.0 0.9 0.5 0.0 -0.0 -0.8 -0.2 0.6 -0.5 -0.0 -0.8 0.3 0.4 0.7 0.8 0.7
Schizophrenia (2018) 1.0 2.2 5.3 -1.8 1.2 2.0 -0.9 -2.3 -1.9 -1.4 0.4 0.2 -1.5 -1.7 0.1 -1.5 -1.1 -1.9 2.0 -2.1 -1.8 -1.7 0.4 -0.3 -1.9 0.5 -0.8
Schizophrenia vs Biploar Disorder 2.0 2.7 5.9 -2.3 0.6 2.2 -0.4 -2.3 -2.2 -1.7 1.0 1.0 -1.4 -2.1 0.8 -1.6 -1.2 -2.2 1.6 -2.4 -1.9 -2.2 0.9 -0.6 -1.4 1.3 -0.1
Worry (Nagel 2018) 0.3 0.6 1.9 -1.1 0.8 0.7 0.7 -0.7 -1.0 -0.8 0.2 -0.4 -0.6 -0.6 -0.3 -1.4 -1.1 -1.0 0.9 -0.9 -1.0 -1.3 -0.2 -0.4 -0.7 0.1 -0.5
Alzheimer’s Disease (in mother) 2.7 3.2 7.8 2.1 -1.0 0.5 0.1 1.6 2.0 2.2 2.8 -1.3 2.5 1.5 -1.6 1.8 0.5 1.6 2.2 2.0 2.2 2.3 1.7 2.7 1.6 -1.1 -0.6
Alzheimer’s Disease (in father) 1.0 1.1 5.5 -0.5 -2.3 -1.4 0.2 -0.9 -1.1 -1.1 -1.5 1.1 -0.1 -0.9 1.4 0.7 0.3 0.8 -1.3 -1.0 -0.8 -0.9 -0.5 -1.7 -0.2 0.8 0.7
Alzheimer’s Disease (including proxy) 0.3 0.4 2.2 0.4 -1.5 0.4 0.2 -0.1 -0.0 0.2 0.8 -0.5 0.7 -0.3 -0.6 0.8 -0.2 0.7 1.3 0.1 0.2 0.3 0.9 0.7 -0.0 -0.2 -0.5
Crohns Disease (2017) 0.4 0.9 6.1 -0.5 -0.4 -0.7 0.9 -0.4 -1.1 -1.4 -0.9 1.0 -0.2 0.3 1.1 0.2 2.5 0.8 -1.3 -0.7 -0.7 -0.8 0.5 -0.3 0.2 1.2 1.3
Irritable Bowel Disease (IBD) 1.2 2.9 6.7 -2.1 -0.3 -0.2 0.6 -2.1 -2.4 -2.6 -1.3 1.8 -1.1 -1.6 2.4 -0.8 2.1 0.1 -1.7 -2.2 -2.0 -2.3 0.7 -1.1 -0.8 2.5 1.9
Ulcerative Colitis (UC) 2.1 3.9 8.8 -2.7 -0.3 0.6 0.2 -3.0 -2.8 -2.9 -1.1 1.6 -1.6 -2.7 2.5 -1.5 0.6 -0.5 -1.2 -2.7 -2.5 -2.8 0.7 -1.3 -1.6 2.7 1.4
Major Depression (MDD) 1.1 1.3 4.2 -1.4 -0.5 0.4 0.3 -2.0 -1.6 -1.3 -0.4 0.5 -0.9 -1.1 1.1 -0.9 2.0 0.8 -0.2 -1.6 -1.4 -1.1 1.4 0.0 -1.4 1.0 0.2
Reaction Time 0.7 1.3 4.6 1.0 -0.9 0.4 0.9 0.9 0.9 1.1 2.2 -1.4 1.5 1.2 -0.6 0.9 0.1 1.0 1.9 1.1 1.4 1.0 1.1 0.8 1.4 -0.8 -0.2
Verbal and Numeric Reasoning (VNR) 1.4 3.3 16.4 -1.2 -1.8 -2.3 -1.1 -0.4 -1.1 -0.6 -4.0 3.3 -1.6 -1.3 1.9 0.6 0.2 0.4 -3.2 -1.4 -1.6 -1.2 -1.8 -2.3 -0.6 1.4 1.7
Breast Cancer 0.8 1.9 12.9 -0.7 -0.3 -2.2 -1.3 -0.4 -0.5 -1.1 -3.2 1.4 -0.9 -0.7 1.3 0.2 0.1 0.1 -3.6 -0.3 -0.7 -0.2 -1.6 -1.1 -0.1 1.1 1.8
Ovarian Cancer 0.2 0.3 0.9 -0.4 -0.5 -0.9 -0.1 0.0 -0.3 -0.9 -0.1 0.5 0.1 -0.3 0.7 0.0 -0.9 0.9 0.4 -0.1 -0.0 -0.2 0.7 0.1 0.0 0.8 0.4
Prostate Cancer 0.4 0.6 2.5 -0.6 0.9 0.7 1.0 -0.2 -0.2 -0.2 0.6 -1.6 1.6 1.4 -0.5 0.7 0.9 1.0 0.7 -0.0 -0.2 -0.5 0.3 -0.0 -0.1 -0.6 -0.7
Age at First Birth 0.1 0.2 1.3 -0.3 0.0 -0.1 0.4 0.2 -0.1 0.2 -1.1 0.9 -0.3 0.1 0.3 0.2 0.5 0.0 -0.8 -0.3 -0.3 -0.2 -0.7 -0.4 -0.2 0.2 0.2
Bipolar Disorder (2011) 0.4 0.4 2.2 0.1 0.8 -0.7 1.2 0.7 0.3 0.6 -0.6 0.7 0.6 1.0 -0.0 0.8 1.5 0.8 0.3 0.3 0.2 0.5 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.5 0.7 3.1 0.7 0.8 1.4 0.4 0.5 0.7 0.6 0.2 -0.6 0.6 1.0 -1.3 0.3 -0.5 -0.4 -0.7 0.7 0.6 0.6 -1.8 -0.4 0.3 -1.7 -1.1
Coronary Artery Disease (CAD) 0.7 0.9 5.2 0.2 -1.2 1.4 -0.0 -1.3 -0.2 -0.1 2.3 -1.2 0.1 0.4 -0.8 -0.5 1.4 0.7 1.3 -0.2 0.2 -0.0 1.6 0.9 0.5 -0.3 -0.8
Crohns Disease (2012) 0.7 1.1 4.2 -0.5 0.0 -1.5 0.3 -0.1 -0.6 -0.7 -1.5 1.2 0.4 0.8 1.0 0.9 2.1 1.0 -2.0 -0.2 -0.3 -0.4 -0.6 -0.4 0.7 1.3 1.8
Mean Putamen Volume 1.5 1.7 5.5 -0.8 0.3 2.0 -0.5 -1.9 -1.1 -1.4 0.6 -0.9 -1.9 -1.7 -0.1 -2.3 -0.7 -1.9 0.3 -1.3 -1.5 -1.4 0.8 -0.5 -1.5 -0.1 -1.2
Fasting Glucose 1.0 1.2 6.1 -0.0 -1.4 -1.3 2.5 0.3 0.1 0.1 -0.5 0.4 1.6 0.6 1.4 1.1 1.3 2.0 -1.2 0.3 0.2 0.2 0.0 -0.8 1.3 1.1 1.7
HbA1C 2.3 2.5 8.0 -1.9 0.9 0.3 -0.3 -1.4 -1.8 -1.6 -1.4 0.1 -2.3 -2.8 0.6 -1.9 -2.0 -2.0 -0.6 -1.8 -2.1 -2.1 -1.0 -1.3 -2.2 0.8 -0.5
HDL Cholesterol 1.6 2.7 9.7 -1.7 -1.1 -2.2 -1.1 -0.9 -1.5 -0.9 -2.5 3.1 -1.6 -2.4 2.4 -0.5 0.3 0.8 -0.7 -1.9 -1.8 -1.1 0.6 -1.3 -1.3 1.9 1.6
LDL Cholesterol 0.9 1.4 5.3 -0.3 0.6 2.3 -1.7 -1.3 -0.4 -0.3 1.3 -1.9 -0.8 -0.8 -0.7 -1.4 -1.6 -1.5 1.1 -0.4 -0.5 -1.0 -0.1 -0.4 -1.2 -1.0 -2.1
Lupus 0.5 0.8 2.9 -1.3 0.4 0.8 0.0 -1.3 -0.9 -1.1 -0.1 -0.9 -0.5 -1.2 0.5 -0.8 -1.7 -1.3 0.5 -0.9 -0.8 -1.1 0.6 -0.4 -0.9 0.4 -0.4
Neuroticism (2016) 0.2 0.3 1.7 -0.1 1.1 0.3 1.3 0.1 -0.4 -0.5 0.8 -0.7 0.7 0.3 -0.8 -0.2 -0.0 0.5 0.2 0.0 0.4 -0.2 0.0 0.3 0.3 -0.6 -0.3
Primary Biliary Cirrhosis 3.9 5.6 13.9 -3.0 1.1 2.8 -0.9 -3.7 -3.2 -2.8 0.3 -0.1 -2.5 -3.7 0.4 -2.6 -2.7 -2.5 0.1 -3.4 -3.2 -3.2 0.1 -0.9 -2.9 1.1 -1.0
Rheumatoid Arthritis 0.2 0.2 0.9 0.6 -0.9 -0.5 0.2 0.4 0.3 0.4 -0.1 0.5 0.3 0.3 0.5 0.4 0.5 0.3 0.4 0.1 0.2 0.4 0.9 0.5 0.3 0.5 0.6
Schizophrenia (2014) 0.8 1.7 4.1 -1.5 0.8 1.7 -1.0 -1.6 -1.2 -0.7 0.3 -0.4 -1.3 -1.5 -0.2 -1.5 -1.7 -2.0 1.7 -1.7 -1.5 -1.5 -0.0 -0.5 -1.6 0.1 -1.1
Triglycerides 8.0 13.2 31.7 3.7 3.5 4.5 -0.2 2.1 3.6 2.9 5.6 -5.6 1.9 3.4 -5.4 -0.3 -2.3 -1.9 4.2 4.0 4.0 3.0 0.9 3.8 1.4 -5.3 -4.9
Type 2 Diabetes (T2D) (2012) 2.0 2.3 5.3 -1.9 -0.8 -1.4 1.0 -1.8 -1.8 -1.6 -1.6 2.3 -0.0 -1.4 1.4 0.4 2.3 1.4 -1.7 -1.6 -1.6 -1.8 -0.4 -1.2 -0.4 1.8 1.7
Ulcerative Colitis 1.7 2.4 5.9 -1.7 -0.7 -0.6 0.3 -2.1 -1.9 -1.6 -1.5 2.2 -0.8 -2.2 2.4 -0.4 1.7 0.2 -1.5 -1.8 -1.7 -1.7 0.6 -1.1 -0.8 2.4 1.8
Blood Eosinophil Count 0.1 1.0 6.5 0.8 -0.8 -2.5 -0.2 1.7 0.7 0.1 -0.3 -0.5 1.0 1.2 0.5 0.9 0.3 0.9 -0.3 1.1 1.0 1.2 0.6 -0.0 1.5 0.3 1.1
Blood Platelet Count 6.0 69.8 148.8 11.2 1.9 1.0 -1.9 10.9 12.0 10.8 8.7 -10.6 5.9 9.1 -10.9 3.0 -0.5 -1.4 7.5 12.2 11.0 11.6 -0.4 7.1 7.0 -11.0 -6.7
Blood Red Count 1.8 17.3 74.1 0.6 -4.9 -8.6 4.7 3.2 0.6 1.0 -3.7 5.4 3.4 1.1 6.0 5.1 4.3 6.9 -2.4 0.7 1.2 2.1 1.4 -1.9 3.5 4.6 6.8
Blood White Count 1.1 8.5 22.5 3.0 2.1 2.8 -4.2 1.9 2.8 2.4 3.5 -4.7 -0.2 1.6 -4.6 -1.6 -3.1 -3.6 1.4 2.7 2.5 2.2 -0.6 1.7 0.7 -4.7 -4.3
Heel T-Score 1.9 14.9 74.6 2.3 1.4 4.5 1.0 4.0 3.8 5.2 5.4 -4.3 1.6 1.7 -3.9 -0.4 -5.8 -3.7 8.6 3.8 3.0 2.0 2.6 3.9 1.0 -3.7 -4.0
BMI 0.6 3.4 8.3 2.6 -0.7 0.3 -0.2 2.5 2.4 2.0 2.5 -1.8 1.8 2.9 -1.8 1.1 0.7 0.2 0.7 2.5 2.8 2.0 0.3 1.7 2.3 -2.0 -0.7
Height 0.9 17.8 118.8 -1.6 -4.3 -5.5 -1.4 -3.1 -3.1 -3.1 -6.9 4.8 -1.4 -4.8 4.5 1.5 -0.0 1.8 -10.9 -3.4 -2.9 -2.7 -3.2 -4.4 0.1 4.3 5.4
Waist Hip Ratio (WHR) 0.2 1.0 4.2 0.1 -0.5 0.5 1.8 0.5 0.4 0.9 1.8 0.5 1.5 0.2 -0.1 0.9 0.4 0.6 1.2 0.0 0.6 -0.4 1.8 2.1 1.3 0.9 0.8
Systolic Blood Pressure 0.3 1.7 3.6 1.4 -0.3 -0.9 0.7 1.8 1.5 1.3 0.9 -1.2 1.8 1.4 -1.3 1.3 0.9 1.5 1.9 1.7 1.6 1.6 0.2 0.8 1.0 -1.7 -1.0
Smoking Status 0.2 0.6 4.4 0.3 -1.3 0.3 -0.8 -0.5 -0.1 -0.1 1.1 0.2 0.5 -0.4 0.4 0.6 -1.0 0.5 0.2 -0.1 0.3 -0.1 2.1 1.2 0.5 0.7 0.5
Allergy or Eczema 0.1 0.4 2.9 -0.3 1.7 1.0 0.3 0.1 -0.3 -0.0 -0.6 -0.2 -0.6 0.6 -0.2 -0.6 -0.2 -0.4 0.8 -0.3 -0.5 -0.5 0.5 0.2 -0.7 -0.6 -0.6
Cardiovascular Disease 0.3 1.1 5.9 0.1 0.0 1.1 -1.9 -0.2 0.3 0.3 1.2 -1.8 -0.5 -0.9 -1.4 -1.0 -0.4 -0.9 1.7 0.1 -0.1 0.0 0.2 0.6 -1.4 -1.1 -2.4
Hypothyroidism (self reported) 1.0 2.4 11.0 0.6 1.8 3.3 -2.1 -0.3 0.5 0.3 2.1 -2.5 0.0 0.6 -2.8 -0.6 -1.7 -1.4 0.8 0.3 0.5 0.2 0.3 2.3 -0.4 -1.6 -2.2
Respiratory disease 0.1 0.2 1.2 -0.2 1.1 -0.3 -0.7 0.3 -0.3 -0.3 0.3 0.2 -0.2 -0.0 0.3 -0.3 -0.8 -0.1 0.0 -0.1 0.1 -0.2 1.0 0.3 0.2 0.2 0.1
Type 2 Diabetes (T2D) (2018) 0.3 0.6 3.1 1.0 -0.9 -0.4 0.1 0.4 0.8 1.3 0.5 0.0 0.6 1.0 -0.2 0.8 1.8 0.9 0.4 0.5 0.8 0.8 0.7 0.8 0.7 -0.2 0.2
Lung FEV1/FVC ratio 0.3 1.4 8.5 0.9 -1.3 -0.6 1.3 0.9 1.0 0.6 0.5 -0.5 1.5 2.9 0.2 1.3 1.7 1.5 -1.1 1.3 1.2 1.2 -0.9 -0.5 1.4 -0.2 0.7
Lung FVC 0.8 4.1 22.2 -0.6 3.4 4.7 0.8 -1.8 -0.2 -0.1 3.0 -2.3 -0.1 -0.2 -2.5 -1.3 -2.3 -2.0 3.3 -0.1 -0.3 -1.2 0.7 1.6 -1.2 -1.6 -2.9
Neuroticism 0.1 0.3 1.8 -1.1 0.7 0.5 0.4 -0.5 -0.9 -0.6 0.3 -0.3 0.1 -0.1 -0.2 -0.3 -0.7 -0.4 0.8 -0.9 -0.8 -1.3 0.0 -0.2 -0.2 0.3 -0.1
Chronotype (morning person) 0.6 1.4 3.1 -1.7 0.9 1.6 1.8 -1.1 -1.6 -1.5 1.1 0.4 -0.7 -1.1 0.7 -1.1 1.1 -0.4 1.5 -1.5 -1.2 -1.6 0.9 -0.2 -1.0 1.0 -0.3
Hair Pigment 0.1 2.0 8.0 1.7 -0.2 -1.4 -0.6 2.1 1.8 2.0 -0.6 -1.1 0.9 1.3 -1.5 0.9 0.2 0.1 -1.1 1.8 1.4 1.5 -2.8 -1.0 1.3 -1.9 -0.4
Tanning 0.2 2.1 4.5 -1.6 1.0 0.4 1.3 -2.0 -1.9 -1.6 -1.5 1.7 -0.4 -2.1 1.6 -0.1 -0.5 0.1 -1.7 -2.1 -1.7 -2.0 0.7 -0.1 -1.1 2.0 1.3
Hand grip strength (left) 0.4 1.1 3.6 -1.1 -0.0 -0.8 -1.1 -1.4 -1.2 -1.0 -1.6 0.7 -0.8 -0.7 1.4 -0.4 -0.1 -0.1 -1.9 -1.1 -1.1 -0.9 -1.1 -1.8 -0.9 0.7 0.6
Number of treatments/medications taken 0.7 1.2 5.3 -1.2 0.9 2.3 -0.2 -1.3 -1.4 -1.3 1.1 -0.7 -0.7 -0.7 -0.7 -0.6 0.1 -0.6 1.4 -1.3 -1.2 -1.5 0.8 0.4 -1.4 -0.2 -1.4
Average weekly spirits intake 0.9 1.1 2.6 1.3 -1.2 -1.2 0.9 0.8 1.1 1.3 -0.9 1.1 0.7 1.3 -0.3 1.3 1.0 1.0 -1.6 1.0 0.9 0.9 -1.0 0.2 1.3 -0.2 0.9
Sensitivity / hurt feelings 0.3 0.5 2.2 -0.7 1.5 1.3 0.3 -0.3 -0.5 -0.2 0.8 -0.7 -0.3 0.6 -0.3 -0.7 -0.3 -0.8 1.4 -0.4 -0.5 -0.5 0.3 -0.2 -0.5 -0.1 -0.7
Frequency of depressed mood in last 2 weeks 0.4 0.5 2.6 -0.8 0.8 -0.8 -1.6 0.4 -0.2 0.0 -0.2 -0.5 0.4 0.2 0.8 0.4 -1.6 -0.4 -0.4 -0.1 -0.0 -0.1 0.5 0.1 0.7 1.0 1.1
Hearing difficulty/problems: Yes 0.4 0.5 3.9 0.1 1.4 -0.0 0.5 0.2 0.1 -0.7 -0.7 1.4 -0.7 0.5 -0.9 0.1 0.5 -0.3 -1.1 0.3 -0.1 0.4 -2.0 -0.3 0.3 -0.3 0.2
Relative age of first facial hair 0.5 1.1 5.9 0.9 0.5 1.0 -0.4 0.5 0.8 0.3 1.0 -1.8 0.7 0.7 -1.4 0.1 1.3 0.3 0.8 0.9 0.7 0.5 0.2 0.1 -0.4 -2.4 -2.2
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 2.2 -0.7 0.9 0.5 0.4 -0.8 -0.9 -1.5 0.1 0.1 0.2 0.8 0.5 0.1 0.9 0.7 -0.1 -0.5 -0.3 -0.5 0.6 0.2 0.1 0.6 0.5
Ever used hormone-replacement therapy (HRT) 0.5 0.6 3.2 0.5 -0.7 -0.1 -0.5 0.3 0.1 -0.1 -0.8 0.3 -1.2 0.8 -0.5 -0.7 1.5 -0.3 -1.3 0.0 -0.0 0.3 -1.8 -1.1 -0.4 -1.2 -0.6
Ever had hysterectomy (womb removed) 0.8 0.9 2.7 1.2 0.9 0.4 0.1 1.3 1.1 0.9 1.1 -0.7 0.1 0.1 -1.6 -0.0 0.5 -0.3 1.2 1.1 1.0 1.3 0.2 1.1 0.5 -1.6 -1.1
Systolic blood pressure, automated reading 2.0 5.9 13.5 2.8 0.3 0.7 1.2 2.8 2.8 2.1 3.5 -2.7 2.3 3.0 -3.0 1.2 0.8 1.1 3.7 3.1 3.2 2.9 1.1 2.5 2.0 -2.9 -2.0
Eye problems/disorders: Diabetes related eye disease 0.3 0.4 2.0 0.0 -1.4 -0.5 0.7 0.2 -0.2 -0.7 -0.3 0.1 0.7 -0.0 0.4 0.7 -0.2 0.3 -1.4 -0.0 0.2 -0.2 -0.8 -0.7 0.5 0.1 0.6
Angina 0.3 0.4 3.6 0.3 -0.8 0.1 -0.4 0.2 0.4 1.2 0.7 -0.2 0.4 0.6 -0.5 0.5 1.9 0.8 0.4 0.1 0.2 0.4 -0.6 -0.6 -0.1 -0.8 -0.7
Medication for hormone replacement therapy 0.3 0.3 1.7 -0.1 0.6 0.8 -0.7 -0.4 -0.2 -0.2 -0.0 -0.0 -1.3 -0.1 -0.4 -1.1 -0.6 -1.2 0.3 -0.2 -0.3 0.1 0.0 0.1 -0.6 -0.6 -0.7
Vitamin and mineral supplements 1.3 1.8 5.9 1.5 1.3 0.3 -2.0 1.1 1.6 1.6 -0.1 -1.6 -0.4 0.3 -2.2 -0.4 -2.4 -1.7 -0.6 1.4 1.0 1.1 -1.1 1.2 0.4 -1.8 -1.3
Supplements: Zinc 1.4 1.5 3.4 -1.4 0.7 0.4 -0.7 -1.4 -1.5 -1.1 -1.5 1.6 -1.9 -1.1 1.2 -1.5 -0.4 -1.2 -0.7 -1.6 -1.7 -1.3 -0.2 -0.9 -1.5 1.2 0.6
Medication: Co-codamol 0.5 0.6 1.6 0.7 -0.2 -0.5 0.1 1.0 0.5 0.1 0.5 0.4 1.1 1.2 -0.2 1.2 0.4 1.2 -0.7 0.5 0.8 0.8 0.2 1.0 1.1 0.4 0.8
Medication: Metformin 0.2 0.3 2.2 -0.0 -1.5 -0.4 0.9 -0.2 0.1 0.5 0.1 0.6 0.4 -0.3 0.7 0.5 0.8 0.8 -0.1 -0.0 0.2 0.2 0.4 0.0 0.6 0.6 1.0
Diabetes (father) 1.7 2.0 3.9 -1.0 -1.9 -0.6 -1.2 -1.6 -1.5 -1.1 -1.7 1.3 -1.8 -1.4 1.9 -0.9 0.9 0.0 -1.9 -1.8 -1.9 -1.4 -0.4 -2.0 -1.3 1.6 0.9
Diabetes (mother) 0.8 1.0 3.5 -0.9 -0.9 0.8 -1.6 -1.2 -0.9 -0.3 0.2 0.3 -1.9 -1.7 0.2 -1.0 -1.3 -1.1 0.5 -1.3 -1.2 -1.1 0.3 -0.4 -1.1 0.4 -0.3
Severe depression (siblings) 0.7 0.8 3.2 -1.2 -0.2 0.0 0.2 -1.1 -1.2 -0.9 0.2 1.1 -0.2 -0.7 1.1 -0.3 0.1 0.3 0.4 -1.3 -0.8 -0.8 1.8 0.7 -0.3 1.6 1.0
Pack years adult smoking proportion 0.8 1.2 2.8 -1.2 1.4 0.3 -1.3 -0.8 -1.1 -1.0 -1.1 -0.2 -1.4 -1.5 0.4 -1.4 -1.7 -1.4 -0.6 -1.1 -1.2 -1.6 0.8 -0.3 -1.1 0.1 -0.3
Impedance of leg (right) 0.6 3.1 6.7 -2.6 -0.4 -0.7 -0.2 -2.2 -2.4 -1.9 -1.9 1.5 -1.4 -2.5 2.6 -0.7 -1.5 -0.8 0.2 -2.3 -2.4 -2.0 1.4 -0.9 -1.9 2.5 1.1
Leg fat-free mass (left) 0.3 1.3 11.0 1.4 -1.8 -1.3 -0.8 0.7 0.6 0.3 -0.2 0.2 0.6 0.6 0.0 1.1 1.5 1.0 -3.3 0.6 1.1 0.6 -1.3 -0.7 1.6 -0.3 1.0
Trunk fat percentage 0.1 0.5 2.8 0.1 0.6 1.3 -0.7 -0.3 -0.1 -0.2 1.0 -0.7 -0.9 -0.3 -0.6 -1.0 -0.7 -1.7 0.3 -0.1 0.1 -0.3 0.6 0.5 -0.4 -0.7 -0.9
Hand grip strength (right) 0.3 0.9 4.6 0.2 -0.8 -2.1 -1.4 -0.1 0.1 0.4 -1.2 0.6 0.8 0.6 1.1 1.4 -0.2 1.0 -1.9 0.1 0.3 0.2 -0.3 -0.7 0.7 0.5 1.3
Townsend deprivation index at recruitment 1.0 1.4 3.2 -1.5 0.8 0.9 -0.8 -1.3 -1.5 -1.5 0.0 -0.0 -1.6 -1.8 0.8 -1.8 -1.8 -1.4 0.2 -1.4 -1.3 -1.5 0.9 -0.2 -1.3 1.0 0.0
Current tobacco smoking 0.6 1.0 4.2 1.0 0.5 0.2 -1.1 0.8 0.8 1.0 1.5 -1.0 1.0 0.1 -1.1 1.0 -2.0 -0.2 0.8 0.6 0.9 0.6 1.6 1.9 0.9 -0.5 -0.3
Average weekly fortified wine intake 1.2 1.4 3.7 1.4 0.3 -1.1 0.2 1.4 1.5 1.5 -1.0 0.4 1.4 1.3 -0.8 1.9 0.4 1.4 -1.6 1.4 1.2 1.5 -1.1 0.6 1.4 -0.5 0.7
Maternal smoking around birth 0.2 0.3 1.9 0.2 0.6 0.3 -1.2 0.1 0.1 -0.3 0.2 -0.5 -0.6 -0.3 -0.6 -0.6 -0.4 -1.4 0.0 0.1 -0.1 0.0 0.1 0.1 -0.3 -0.6 -0.8
Fed-up feelings 0.6 1.1 3.2 0.9 0.2 -1.7 0.6 1.7 0.9 1.2 -0.3 0.7 1.3 1.4 0.4 1.5 -0.5 0.6 -0.3 0.9 1.3 0.8 0.4 0.8 1.8 0.5 1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 2.1 -1.1 1.1 0.8 -0.3 -0.8 -1.1 -0.8 0.6 -0.5 -0.5 -0.2 0.9 -1.0 -0.6 -0.9 0.2 -1.1 -0.8 -1.1 1.5 0.3 -0.5 1.3 0.5
Relative age voice broke 0.2 0.3 1.0 0.4 -0.1 -0.1 -0.9 0.1 0.2 -0.0 0.1 -0.6 0.8 0.4 -0.2 0.9 0.6 1.0 -0.2 0.4 0.3 0.1 0.6 -0.2 -0.1 -0.8 -0.8
Taking other prescription medications 0.3 0.5 3.8 -0.3 1.9 1.1 -0.1 -0.3 -0.5 -0.7 0.7 -0.5 -0.0 0.3 -1.2 -0.1 -0.0 -0.3 0.7 -0.3 -0.3 -0.4 0.3 0.9 -0.3 -0.5 -0.9
Age when periods started (menarche) 0.6 1.3 5.8 -0.9 1.6 2.4 -0.6 -1.4 -0.6 -0.9 0.8 -1.1 -1.1 -0.3 -1.3 -2.0 -0.1 -1.7 0.2 -0.5 -0.9 -1.0 -0.8 0.2 -1.4 -0.7 -1.7
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 2.3 -0.2 0.6 -0.2 1.2 0.1 -0.6 -0.7 -0.3 1.5 -0.0 0.1 0.3 0.5 0.2 0.4 -0.2 -0.4 -0.1 -0.4 0.5 0.3 0.2 0.3 0.6
Heel bone mineral density (BMD) T-score, automated (left) 4.2 9.5 27.7 3.1 1.9 2.8 1.0 3.0 3.6 4.0 4.6 -3.5 2.3 1.9 -3.7 1.0 -2.4 -0.8 5.3 3.6 3.3 3.1 2.2 4.3 1.5 -3.1 -2.9
Tinnitus: Yes, but not now, but have in the past 2.2 2.4 5.4 2.2 1.3 -0.1 -1.2 1.8 2.3 1.7 1.8 -1.6 1.2 1.0 -2.0 0.5 0.0 0.3 0.6 2.2 2.3 2.2 -0.0 1.3 1.5 -2.2 -1.0
Qualifications: CSEs or equivalent 0.9 1.2 3.5 0.6 1.4 1.0 -0.3 0.8 1.1 1.7 1.3 -1.9 -0.1 1.1 -1.0 -1.0 0.1 -1.6 1.7 0.8 0.6 0.6 0.3 0.3 -0.1 -1.3 -1.5
Serious illness, injury or assault to yourself 0.6 0.7 2.2 1.0 -0.2 -0.1 0.9 0.8 0.7 0.9 1.5 -1.0 1.4 0.9 -0.8 1.0 0.5 0.8 0.6 0.7 1.1 0.6 0.5 0.7 1.1 -0.8 -0.2
High blood pressure 0.3 0.8 3.9 -0.2 0.3 1.5 -0.9 -0.5 -0.3 -0.4 0.8 -0.9 -1.0 -0.6 -1.1 -1.1 -0.7 -0.8 1.7 -0.3 -0.5 -0.3 0.0 0.2 -1.5 -0.7 -2.0
Hayfever, allergic rhinitis or eczema 0.1 0.3 2.0 0.2 1.4 0.9 1.0 0.4 0.1 -0.1 -0.3 -0.3 -0.0 1.0 -0.6 -0.2 -0.0 0.1 0.3 0.2 0.0 0.1 0.0 0.4 -0.4 -0.9 -0.6
Multivitamins +/- minerals 1.0 1.2 4.9 -1.2 -1.4 -0.3 1.5 -0.7 -1.5 -1.7 -0.2 1.2 -0.0 -0.1 1.7 0.2 2.2 1.3 0.2 -1.1 -0.9 -0.9 0.7 -1.3 -0.5 1.1 0.7
Stomach or abdominal pain in last month 0.6 0.7 2.0 -0.9 1.1 -0.1 -0.4 -0.9 -1.2 -1.0 -0.4 1.1 -0.6 -0.3 1.0 -0.4 0.5 -0.7 -0.5 -1.1 -0.9 -1.1 1.4 0.7 -0.2 1.4 1.0
Supplements: Glucosamine 1.3 1.7 4.7 -1.1 -1.5 -1.2 0.7 -0.8 -1.6 -1.5 -1.4 1.6 -0.3 -0.2 1.9 0.5 2.2 1.4 -1.8 -1.5 -1.3 -1.2 -0.3 -1.7 -0.6 1.4 1.1
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 0.9 0.7 0.2 -0.9 -0.3 0.7 0.4 0.4 0.5 0.1 0.6 0.2 -0.4 1.0 -0.2 0.2 -0.0 0.2 0.4 0.2 0.8 0.9 0.7 -0.1 0.1
Medication: Atenolol 0.7 0.9 4.1 -0.0 -1.9 -0.2 1.5 -0.3 -0.0 0.1 1.0 -0.6 1.5 0.3 0.6 1.0 2.0 1.4 0.5 0.0 0.3 0.4 1.2 0.2 0.7 0.6 0.7
Medication: Levothyroxine sodium 0.8 1.4 4.9 0.7 1.3 2.2 -1.7 -0.0 0.3 0.1 1.4 -1.9 -0.6 0.1 -2.1 -0.9 -1.4 -1.5 0.6 0.2 0.2 0.2 -0.0 1.1 -0.6 -1.4 -2.0
Sitting height 0.3 2.2 17.6 1.6 -2.4 -2.1 0.6 -0.4 0.1 -0.5 -0.7 -0.2 1.0 -0.3 0.6 1.2 2.8 1.8 -4.2 -0.0 0.6 0.2 -0.1 -0.1 1.7 0.7 1.7
Chronic bronchitis/emphysema (father) 1.2 1.4 3.0 -1.5 -0.3 -0.5 -0.8 -0.7 -1.4 -1.0 -1.6 1.7 -1.6 -1.2 1.5 -1.4 -0.6 -0.6 -1.0 -1.5 -1.5 -1.4 0.3 -0.5 -0.9 1.7 1.2
High blood pressure (mother) 0.4 0.5 1.7 -0.7 -0.5 -0.1 -0.7 -0.4 -0.8 -0.2 -0.9 0.7 -0.9 -0.9 0.1 -0.6 0.2 -0.7 0.3 -0.9 -1.0 -0.9 -0.9 -1.3 -0.8 -0.2 -0.4
Body mass index (BMI) 0.9 3.7 10.8 2.3 0.9 1.5 -0.8 2.0 2.2 2.1 3.3 -2.4 1.0 2.5 -2.5 0.2 -0.1 -0.8 1.5 2.3 2.6 1.9 0.4 1.9 1.7 -2.6 -1.7
Impedance of leg (left) 0.8 3.7 8.0 -2.8 -0.3 -0.3 0.6 -2.6 -2.7 -2.3 -1.6 1.9 -1.2 -2.8 2.6 -0.6 -1.2 -0.5 0.5 -2.6 -2.7 -2.3 1.8 -0.6 -2.0 2.8 1.2
Leg predicted mass (left) 0.3 1.4 11.2 1.4 -1.8 -1.3 -0.8 0.8 0.6 0.3 -0.2 0.2 0.7 0.6 0.0 1.1 1.5 1.1 -3.4 0.6 1.1 0.6 -1.4 -0.7 1.6 -0.4 1.0
Trunk fat mass 0.0 0.2 0.9 0.5 -0.2 0.5 -0.7 -0.1 0.1 -0.1 0.9 -0.4 -0.3 -0.1 -0.3 -0.2 -0.2 -1.0 -0.8 0.1 0.5 -0.0 0.5 0.5 0.4 -0.4 -0.2
Waist circumference 0.4 1.4 8.1 1.2 0.1 1.4 -0.6 0.8 1.0 0.7 2.8 -1.8 0.7 1.2 -1.6 -0.0 -0.1 -0.7 0.3 1.0 1.6 0.6 0.9 1.5 1.3 -1.4 -1.0
Number of incorrect matches in round 0.3 0.5 1.9 0.5 0.4 0.3 -0.3 0.3 0.4 0.8 1.4 0.5 0.1 -0.5 -0.3 -0.2 -1.3 -0.7 0.8 0.3 0.7 0.7 1.1 1.1 0.8 0.2 0.3
Past tobacco smoking 1.1 2.0 4.8 1.7 1.3 -0.4 0.9 2.2 1.9 2.0 0.9 -1.4 1.6 2.2 -1.5 1.1 0.0 -0.2 0.7 2.0 1.8 2.0 -0.3 1.2 1.4 -1.3 -0.4
Alcohol usually taken with meals 0.4 0.6 5.4 0.2 -1.1 -0.7 0.4 0.0 0.1 0.1 -0.2 0.5 0.8 0.8 0.5 1.3 2.3 1.3 -0.6 0.1 0.2 0.5 0.0 -0.3 0.4 0.0 0.4
Nervous feelings 0.7 1.2 2.9 -1.5 1.3 1.2 0.3 -1.1 -1.3 -1.0 -0.8 -0.3 -1.2 -0.7 0.0 -1.6 -1.2 -1.4 0.0 -1.4 -1.6 -1.7 -0.9 -0.9 -1.5 0.4 -0.4
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.4 2.2 -0.8 0.8 -0.6 -0.4 0.0 -0.4 0.3 0.3 -0.2 0.7 0.2 0.7 0.4 -1.0 -0.3 0.7 -0.4 -0.1 -0.4 1.5 0.4 0.5 0.9 0.7
Hearing difficulty/problems with background noise 1.4 2.3 10.6 -1.3 -1.0 -0.6 0.0 -1.6 -1.4 -1.6 -2.2 3.3 -1.4 -1.4 1.1 0.2 0.4 0.1 -2.6 -1.5 -1.8 -1.1 -1.3 -1.1 -0.6 1.9 1.7
Hair/balding pattern: Pattern 2 1.2 1.5 3.9 -1.2 1.5 1.1 -0.5 -1.3 -1.1 -0.7 -1.0 -0.0 -2.0 -1.8 -0.1 -1.9 -0.6 -1.9 -0.1 -1.2 -1.5 -1.1 -1.1 -1.0 -1.8 -0.1 -0.7
Had menopause 2.0 2.5 6.7 -1.0 1.5 1.9 -0.5 -1.6 -0.9 -1.5 -0.6 -0.2 -2.6 -2.3 -1.2 -2.6 -0.5 -1.9 -0.3 -0.9 -1.4 -1.0 -1.9 -1.1 -2.4 -1.4 -2.2
Had other major operations 1.5 1.8 5.7 1.4 -0.9 -2.4 -0.5 1.9 1.1 0.8 -0.6 0.1 1.3 1.8 0.2 1.9 1.9 1.6 -1.6 1.4 1.4 1.6 -0.3 0.2 1.9 0.2 1.4
Forced vital capacity (FVC) 0.2 0.7 3.1 -0.6 -0.3 -0.2 0.0 -1.1 -0.9 -0.9 -0.9 0.4 0.1 -1.2 0.5 0.5 -1.0 -0.4 -1.8 -0.9 -0.8 -1.2 -0.6 -0.7 -0.0 1.0 0.8
Heel bone mineral density (BMD) T-score, automated (right) 4.0 9.1 29.3 2.7 1.8 2.9 0.8 2.7 3.2 3.5 4.6 -3.5 2.2 1.9 -3.8 1.1 -2.5 -0.9 5.4 3.3 3.1 2.7 2.7 4.7 1.3 -2.9 -3.0
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.4 -0.7 1.2 -0.9 -0.1 -0.3 -0.7 -0.8 -0.5 1.0 -0.2 0.1 1.0 0.3 0.9 0.2 -0.5 -0.6 -0.3 -0.4 0.2 -0.2 -0.0 1.0 0.9
Qualifications: None of the above 0.7 1.5 8.5 -0.5 1.0 1.3 -1.6 -0.8 -0.9 -1.6 0.8 -1.3 -1.3 -1.1 -0.7 -1.6 -2.9 -1.8 0.4 -0.7 -0.6 -1.1 0.0 -0.3 -1.2 -0.8 -1.5
Financial difficulties in last 2 years 0.7 1.0 4.0 0.3 -0.2 -0.2 0.6 0.5 0.3 1.1 1.9 0.2 1.2 0.9 0.2 1.2 0.8 0.7 1.7 0.1 0.7 0.4 2.0 1.3 1.3 0.8 0.8
Mouth/teeth dental problems 0.3 0.4 4.2 0.0 -0.1 -0.7 1.6 0.3 0.1 0.2 -0.0 -0.3 0.5 0.4 0.5 0.1 2.0 1.0 1.1 0.1 -0.1 0.1 0.2 -0.1 -0.2 0.2 -0.0
Heart attack 0.7 0.9 6.4 -0.2 -0.8 -0.4 1.3 -0.0 -0.4 -0.1 -0.3 0.8 1.1 1.0 0.6 1.4 2.5 1.9 0.1 -0.4 -0.2 0.1 1.0 0.8 0.4 1.2 1.2
Allergy 0.1 0.2 1.3 -0.4 -1.1 0.3 -0.4 -0.6 -0.1 0.0 0.8 -0.1 -0.1 -1.1 0.1 -0.3 0.0 -0.7 0.7 -0.3 -0.2 -0.3 0.5 0.3 -0.2 0.5 -0.1
Pain all over the body in last month 1.1 1.2 2.7 -1.2 0.4 -0.7 -0.4 -0.7 -1.3 -1.5 -1.3 1.5 -1.0 -1.2 1.6 -0.2 -1.3 -0.8 -1.7 -1.2 -1.0 -0.9 0.3 -0.7 -0.3 1.6 1.4
Diabetes (self-reported) 0.8 1.3 4.6 1.8 -0.6 -0.7 0.2 1.3 1.7 2.1 -0.0 -0.4 0.8 1.6 -0.7 1.0 1.3 1.2 -0.0 1.5 1.4 1.6 -0.3 0.7 1.0 -0.9 -0.0
Hayfever/allergic rhinitis (self-reported) 0.6 0.7 2.2 -0.9 -0.8 -0.3 -0.7 -1.3 -0.9 -0.9 -1.4 0.9 -0.6 -1.5 0.7 -0.2 -0.6 -0.3 -1.1 -1.0 -1.0 -1.0 -0.3 -0.5 -1.0 0.8 0.4
Medication: Ramipril 1.7 2.1 5.9 -1.8 1.0 2.4 0.4 -1.8 -1.6 -1.0 0.7 -0.2 -0.7 -2.3 -0.0 -1.5 -0.1 -0.7 2.0 -1.9 -1.6 -2.0 2.0 0.8 -2.2 0.1 -1.4
Medication: Simvastatin 0.5 0.7 2.3 0.7 0.1 1.0 0.4 0.2 0.5 0.5 1.5 -0.8 0.5 -0.1 -0.9 0.3 1.3 0.4 1.5 0.7 0.7 0.6 1.5 1.5 0.1 -0.8 -1.0
Fluid intelligence score 0.7 1.5 8.5 -0.5 -1.4 -1.5 -1.0 -0.3 -0.6 -0.3 -2.9 2.2 -1.2 -1.0 1.0 0.4 0.0 0.0 -2.2 -0.9 -1.0 -0.6 -1.4 -1.5 -0.7 0.6 0.8
Illnesses of siblings 0.5 0.6 3.0 0.0 -0.2 -1.6 0.4 0.7 0.2 0.3 -1.7 0.2 -0.1 0.7 1.4 0.1 -0.4 0.7 -1.4 0.0 -0.1 0.1 -0.2 -0.4 0.3 1.1 1.6
Neuroticism score 0.1 0.3 1.4 -0.7 0.5 -0.5 -0.2 0.3 -0.5 -0.1 -0.8 0.4 -0.4 0.1 0.4 -0.4 -1.2 -0.8 -0.1 -0.6 -0.6 -0.7 -0.3 -0.5 0.0 0.7 0.6
Weight 0.2 0.8 3.2 1.5 -1.1 -0.4 -0.8 0.8 0.8 0.5 1.2 -0.7 0.6 0.7 -0.6 0.8 0.4 -0.0 -1.8 0.9 1.5 0.7 0.1 0.4 1.6 -0.7 0.3
Impedance of arm (right) 1.4 6.6 16.3 -3.5 -1.0 -0.8 -0.1 -3.0 -3.2 -2.7 -3.9 2.4 -2.7 -4.0 3.2 -1.9 -0.3 -0.7 -1.3 -3.3 -3.7 -2.7 -0.4 -2.8 -3.2 2.7 1.2
Arm fat percentage (right) 0.4 1.5 6.7 1.1 0.8 1.6 -0.5 0.8 1.1 1.2 2.6 -1.5 0.2 1.1 -1.6 -0.4 -0.1 -1.1 1.7 1.1 1.4 1.0 0.9 1.6 0.6 -1.5 -1.3
Trunk fat-free mass 0.5 2.7 16.1 1.7 -2.5 -2.2 -0.0 0.8 0.7 0.3 -0.1 0.7 1.7 0.8 0.6 2.4 1.8 2.0 -4.0 0.7 1.5 0.9 -0.5 -0.3 2.5 0.4 2.1
Hip circumference 0.2 0.7 2.5 1.3 -0.9 -0.1 -1.6 0.6 0.7 0.5 0.9 -1.3 0.1 0.7 -0.5 -0.1 0.4 -0.5 -1.3 0.8 1.2 0.7 -0.0 -0.1 0.9 -1.1 -0.3
Time employed in main current job 0.3 0.3 2.2 0.4 -1.5 -0.2 -0.5 -0.1 0.2 0.2 0.3 -0.4 -0.2 -0.1 -0.4 0.2 1.4 0.5 -0.5 -0.0 -0.1 0.1 -0.6 -0.5 -0.1 -0.7 -0.6
Alcohol intake versus 10 years previously 1.2 1.7 5.7 -1.5 0.5 0.6 -1.3 -1.7 -1.5 -1.1 -1.3 -0.2 -1.6 -1.7 0.2 -0.8 -2.4 -1.4 -1.1 -1.6 -1.6 -1.5 -1.4 -1.6 -1.4 0.2 -0.3
Father’s age at death 0.3 0.4 1.0 -0.7 0.1 0.0 -0.6 -0.7 -0.6 -0.6 -0.3 0.8 -0.6 -1.0 0.7 -0.5 -1.0 -0.6 -0.0 -0.7 -0.5 -0.5 0.5 0.2 -0.0 1.0 0.9
Worrier / anxious feelings 0.5 0.9 8.8 -0.4 1.0 -0.8 3.0 1.1 0.1 0.2 0.0 -0.1 1.3 1.4 0.2 0.5 1.2 1.0 0.7 0.3 0.1 0.1 0.3 0.3 0.8 0.6 0.8
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.5 6.2 0.2 1.1 -0.2 0.4 0.7 0.2 0.3 2.0 -1.0 1.9 1.6 -0.5 1.5 1.4 1.3 1.2 0.5 1.0 0.7 2.5 2.4 1.2 0.3 0.2
Falls in the last year 0.3 0.4 1.3 0.8 0.6 -0.4 0.1 1.1 0.5 0.6 -0.2 0.1 0.3 1.1 -1.1 0.8 0.5 0.2 -0.1 0.5 0.4 0.2 -0.4 0.6 0.3 -1.0 -0.6
Hair/balding pattern: Pattern 3 0.3 0.5 4.7 -0.3 -0.5 -0.5 -1.4 -0.1 -0.2 -0.3 -0.9 0.4 -0.5 -0.5 0.4 -0.1 -2.2 -0.8 -0.5 -0.2 -0.3 -0.3 -0.6 -0.6 -0.1 0.4 0.3
Number of live births 0.2 0.3 2.8 0.2 0.9 0.2 0.5 -0.2 -0.0 -0.3 -0.1 0.4 0.7 -0.0 -0.3 0.8 1.4 1.7 -0.4 -0.0 -0.0 0.1 -0.4 0.2 -0.5 -0.0 -0.4
Forced expiratory volume in 1-second (FEV1) 0.1 0.5 3.6 -0.2 -0.3 -0.2 0.6 -0.8 -0.5 -0.4 -0.5 0.5 0.8 0.1 0.4 1.0 0.4 0.1 -1.9 -0.5 -0.3 -0.8 -0.9 -0.5 0.5 0.9 1.0
Pulse rate 0.4 0.7 4.7 0.6 0.8 -0.8 1.2 1.4 0.7 1.0 -0.3 0.3 0.4 1.3 -0.2 -0.0 2.2 0.9 0.8 0.7 0.5 0.5 -0.3 0.1 0.4 -0.6 -0.0
Happiness 0.4 0.5 1.6 -1.3 1.2 0.5 0.4 -0.8 -1.1 -1.1 -0.0 0.1 -0.4 -0.4 0.0 -0.6 0.5 -0.7 0.5 -1.1 -1.0 -1.2 -0.1 -0.2 -0.9 0.3 -0.4
Noisy workplace 0.2 0.3 1.3 0.1 0.1 0.5 0.6 0.0 0.0 0.7 0.6 0.6 0.5 0.7 -0.2 0.6 1.2 0.7 0.8 -0.1 0.3 0.0 0.6 0.9 0.3 0.1 0.2
Qualifications: A levels/AS levels or equivalent 0.6 1.4 5.0 1.1 -1.9 -2.2 0.2 1.1 1.0 1.0 -1.3 1.4 0.9 -0.0 0.3 1.6 1.0 1.5 -1.5 0.8 0.9 1.1 -0.8 0.1 1.2 0.5 1.6
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 1.2 0.0 -0.0 0.8 -1.1 -0.4 0.1 0.2 -0.3 -0.0 -0.8 0.0 -0.7 -0.9 0.3 -1.1 -0.2 -0.1 -0.3 -0.3 -0.7 0.2 -0.7 -0.6 -0.8
Mouth/teeth dental problems: Dentures 0.3 0.6 2.2 0.7 -0.4 0.9 -1.3 -0.3 0.4 -0.1 0.8 -0.9 -0.5 -0.2 -0.8 -0.4 -1.5 -0.5 0.1 0.7 0.6 0.9 1.2 1.2 0.1 -0.8 -0.7
Asthma 0.1 0.3 1.5 -0.0 -0.2 -1.2 -0.1 0.7 -0.2 0.1 -0.3 0.7 0.0 0.1 0.9 0.4 -0.8 0.6 -0.3 -0.1 0.0 0.0 0.7 -0.3 0.4 0.6 0.6
Medication: Ibuprofen (e.g. Nurofen) 1.7 2.1 6.6 0.4 -0.2 -1.0 2.0 0.8 0.2 0.3 1.4 0.7 2.4 1.8 0.5 2.6 1.9 2.3 1.0 0.6 1.2 0.6 2.1 1.7 1.8 1.0 1.5
Medication: Cholesterol lowering 2.8 4.3 8.8 2.6 -0.3 -0.4 0.3 2.3 2.7 2.5 1.2 -2.0 2.9 2.5 -2.1 2.2 2.4 1.7 1.0 3.0 2.7 2.5 -0.4 1.1 2.1 -2.6 -1.1
Depression (self-reported) 0.4 0.5 2.7 -0.2 0.8 0.3 -0.5 -0.6 -0.3 -0.2 0.9 -0.0 -0.4 -1.3 -0.5 -0.6 -0.8 -0.8 1.3 -0.5 -0.2 -0.6 1.1 1.6 -0.2 0.5 -0.1
Medication: Lansoprazole 0.6 0.7 2.7 0.4 1.6 1.3 -1.1 -0.0 0.4 -0.0 1.2 -0.8 0.2 1.1 -0.9 -0.3 1.1 -0.5 0.7 0.6 0.6 0.4 0.4 0.7 0.2 -0.9 -1.0
Prospective memory result 0.5 0.6 2.6 -0.8 0.9 0.2 0.3 -0.5 -0.9 -0.5 -0.1 0.6 -0.6 -1.2 0.4 -0.9 -1.6 -0.4 0.6 -1.0 -0.6 -1.3 0.6 0.7 -0.4 1.2 0.6
Lung cancer (father) 1.6 1.8 8.7 -0.9 1.3 2.4 0.9 -1.1 -0.8 -0.2 2.0 -0.1 -1.0 -1.3 -0.1 -1.8 0.1 -1.5 2.9 -1.0 -0.9 -1.3 2.2 1.0 -1.2 0.3 -1.1
Illnesses of mother 0.4 0.5 1.3 1.1 0.5 -0.7 0.5 1.0 1.1 0.5 -0.3 -0.8 0.2 0.9 -0.3 0.4 -0.5 -0.1 -1.2 1.1 0.9 1.0 -0.5 0.3 0.6 -0.4 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 2.0 -0.4 -0.6 0.1 1.4 -0.8 -0.5 -0.3 -0.1 0.5 0.9 -0.1 0.7 0.9 1.1 0.6 -1.4 -0.5 -0.3 -0.7 -0.6 -0.6 0.5 1.0 1.1
Pulse wave Arterial Stiffness index 1.4 1.7 7.6 -0.5 -2.0 -2.8 -0.6 0.6 -0.5 -0.1 -2.3 1.2 -0.6 -1.4 2.3 -0.0 -1.1 0.1 -1.7 -0.6 -0.7 -0.5 -0.2 -1.7 -0.1 1.5 1.7
Impedance of arm (left) 1.3 6.2 16.3 -3.3 -0.7 -0.6 -0.1 -2.9 -3.1 -2.7 -3.8 1.9 -2.8 -4.0 2.8 -2.0 -0.8 -1.1 -1.1 -3.1 -3.7 -2.7 -0.2 -2.3 -3.3 2.5 0.9
Arm fat mass (right) 0.4 1.6 6.1 1.6 0.3 1.1 -0.4 1.1 1.3 1.2 2.5 -1.6 0.8 1.3 -1.6 0.3 0.3 -0.6 0.5 1.4 1.8 1.2 0.8 1.6 1.3 -1.5 -0.9
Trunk predicted mass 0.4 2.5 15.8 1.6 -2.4 -2.1 -0.1 0.7 0.6 0.2 -0.1 0.7 1.6 0.7 0.6 2.2 1.8 1.9 -4.0 0.6 1.4 0.8 -0.6 -0.4 2.4 0.4 2.0
Standing height 1.0 9.7 48.7 -1.4 -4.3 -3.9 0.4 -2.5 -2.8 -3.1 -4.3 3.6 -0.6 -3.5 4.0 1.4 1.5 1.7 -7.0 -2.8 -2.2 -2.2 -0.8 -2.9 0.1 3.7 4.2
Length of working week for main job 0.2 0.2 2.4 -0.3 0.5 0.7 0.2 -0.0 -0.2 -0.1 -0.1 -0.4 -1.1 -0.4 -0.2 -0.6 -0.6 -1.5 -0.1 -0.2 -0.3 -0.2 -0.3 -0.2 -0.2 -0.2 -0.0
Exposure to tobacco smoke at home 0.2 0.2 1.4 -0.0 0.4 0.2 1.0 -0.2 -0.2 0.0 0.3 0.6 0.3 0.4 0.2 0.2 1.2 0.4 -0.4 -0.2 -0.1 -0.3 0.5 0.6 0.5 0.7 0.6
Breastfed as a baby 0.7 0.8 2.7 -0.9 0.7 1.2 -0.7 -1.2 -0.8 -0.6 -0.4 0.5 -1.3 -1.6 -0.1 -1.2 -0.5 -1.0 0.3 -1.2 -1.2 -1.0 -0.2 -0.1 -1.4 0.0 -0.6
Tense / ‘highly strung’ 0.6 1.0 2.7 -1.0 -1.1 -0.9 0.2 -0.8 -1.2 -0.7 -1.0 1.1 -0.5 -1.4 1.1 -0.3 -1.6 -0.2 -0.1 -1.3 -1.2 -1.3 0.7 -0.3 -0.1 1.6 1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 1.8 0.3 0.8 0.2 -1.1 0.4 0.4 0.5 0.9 -0.5 -0.8 0.1 -1.1 -0.8 0.2 -1.3 1.1 0.1 0.1 0.1 -0.0 0.5 -0.1 -0.6 -0.9
Hair/balding pattern: Pattern 4 0.2 0.5 2.4 -0.1 0.7 -0.6 0.8 0.9 0.0 -0.3 -1.2 0.7 0.2 0.5 -0.4 0.8 0.9 0.9 -1.2 -0.0 -0.4 0.1 -1.5 -0.4 -0.1 0.1 0.3
Birth weight of first child 0.6 1.1 4.7 0.5 -0.8 -1.8 0.8 0.9 0.3 -0.3 -1.0 0.7 0.6 0.5 0.9 1.4 -0.4 1.1 -2.1 0.6 0.6 0.5 0.3 0.0 1.6 0.9 2.2
Peak expiratory flow (PEF) 0.3 0.8 3.8 0.3 -1.0 -1.2 1.1 0.3 0.1 0.3 -1.0 0.9 0.9 1.0 0.8 1.1 0.8 0.9 -2.0 0.2 0.3 -0.2 -1.1 -1.1 0.8 0.6 1.0
Pulse wave reflection index 1.7 2.1 8.0 -0.3 -2.7 -2.8 -0.5 0.8 -0.2 0.4 -2.0 1.5 0.1 -0.9 2.6 1.0 -0.8 0.6 -2.0 -0.7 -0.4 -0.3 0.7 -0.7 0.5 2.4 2.5
Ever highly irritable/argumentative for 2 days 0.3 0.3 1.2 -0.3 0.9 0.5 -1.0 0.3 -0.1 0.2 -0.1 -0.9 -0.3 0.3 -0.2 -0.5 -0.6 -1.0 1.1 -0.2 -0.4 -0.1 -0.1 -0.4 -0.8 -0.4 -0.9
Loud music exposure frequency 1.2 1.3 2.5 -1.1 1.4 1.6 -1.4 -1.4 -1.0 -1.5 -0.1 -0.9 -1.4 -0.4 -0.5 -1.4 -1.5 -1.6 -0.5 -0.8 -0.9 -1.1 -0.8 -0.8 -1.2 -0.9 -1.4
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 4.6 0.4 -0.5 -0.6 1.4 0.5 0.7 0.7 -0.3 0.9 1.2 0.4 0.1 1.2 2.1 1.2 -0.6 0.6 0.5 0.7 -0.3 0.2 0.9 0.4 0.8
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 2.1 -0.6 0.9 1.4 -1.2 -0.6 -0.7 -0.5 0.2 -0.6 -0.8 0.1 -0.6 -1.0 -1.4 -1.4 0.2 -0.8 -0.7 -0.9 -0.4 -0.5 -1.0 -0.6 -1.1
Blood clot in the leg (DVT) 0.3 0.4 3.1 0.3 0.2 0.1 -1.8 0.1 0.3 0.0 -0.7 -0.1 -0.8 -0.5 -0.5 -0.2 -0.6 -0.7 -0.3 0.1 0.0 0.3 -1.1 -0.4 -0.5 -0.7 -0.5
Medication: Paracetamol 0.3 0.5 2.2 0.4 0.7 0.6 0.4 0.6 0.3 0.4 1.5 -0.5 0.2 0.7 -0.6 -0.3 0.6 0.1 1.2 0.3 0.5 0.1 1.3 1.4 0.5 -0.1 -0.3
Headache pain in last month 1.6 2.8 15.8 0.5 1.4 2.8 0.2 0.1 0.3 1.2 3.4 -1.7 0.5 1.3 -1.4 -0.7 -0.1 -1.4 4.0 0.3 0.5 0.0 2.8 2.6 -0.1 -0.7 -1.7
Medication for cholesterol, blood pressure or diabetes 0.6 1.1 4.5 -0.6 -0.1 -1.5 1.0 -0.3 -0.9 -0.6 -0.9 1.8 -0.6 -0.5 1.7 0.2 -1.0 0.1 -1.4 -1.0 -0.6 -0.6 0.4 -0.2 0.5 2.1 2.1
Glaucoma (self-reported) 0.5 0.6 2.0 -1.4 0.6 0.3 -0.2 -1.2 -1.0 -0.6 -0.7 0.8 -0.6 -1.2 0.8 -0.7 -0.0 0.1 -0.2 -1.1 -1.1 -1.3 0.0 -0.8 -1.1 0.3 -0.0
Gout (self-reported) 2.0 2.7 8.5 -2.3 1.2 2.1 2.3 -2.1 -2.3 -2.9 1.6 0.9 0.5 -1.0 0.8 0.3 1.7 0.5 2.1 -1.7 -1.4 -1.8 2.4 0.9 -0.7 1.6 0.2
Hypothyroidism/myxoedema (self-reported) 1.3 2.5 6.8 1.8 1.0 1.8 -1.4 1.1 1.7 1.6 2.2 -2.6 1.1 2.0 -2.4 0.6 -0.7 -0.4 0.8 1.6 1.6 1.4 0.9 2.6 1.0 -1.5 -1.4
Medication: Amlodipine 3.2 4.5 11.6 -2.5 1.2 2.1 -2.0 -2.4 -2.2 -2.2 -1.5 -0.8 -3.0 -2.4 -0.3 -3.0 -0.5 -2.7 0.1 -2.1 -2.6 -2.4 -1.9 -2.1 -3.4 -0.8 -2.1
Medication: Ventolin 100micrograms inhaler 0.9 1.2 4.0 -1.6 -0.2 0.1 0.1 -1.2 -1.7 -2.0 -0.8 0.7 -1.0 -1.4 1.3 -1.0 -0.3 0.2 -0.4 -1.5 -1.5 -1.6 0.4 -0.9 -1.1 1.2 0.5
Birth weight 1.3 2.7 6.5 -1.7 0.9 0.1 0.2 -2.1 -2.2 -2.6 -1.8 2.0 -2.2 -2.3 1.0 -1.5 -1.0 -0.8 -2.0 -2.0 -2.1 -2.2 -0.6 -0.8 -1.2 1.7 1.2
Chronic bronchitis/emphysema (mother) 1.0 1.2 4.3 -1.1 0.8 0.0 -1.7 -0.4 -0.9 -0.9 -0.8 0.4 -1.9 -1.5 0.3 -1.5 -2.1 -2.0 -0.0 -0.9 -1.1 -1.0 -0.4 -1.1 -0.7 0.1 -0.2
High blood pressure (siblings) 0.6 0.8 4.4 0.7 -0.1 1.1 -0.2 0.4 0.6 0.5 2.1 -0.4 0.8 -0.1 -1.5 0.4 0.4 -0.6 1.6 0.7 0.9 0.6 0.7 1.2 0.6 -1.2 -1.2
Forced vital capacity (FVC), Best measure 0.4 1.3 4.2 -1.1 -0.8 -0.3 1.2 -1.4 -1.4 -1.2 -1.1 1.1 0.3 -1.5 1.3 0.6 0.3 0.5 -2.0 -1.4 -1.1 -1.5 -0.4 -1.0 -0.1 1.7 1.5
Body fat percentage 0.2 0.9 3.6 0.4 0.8 1.6 -0.8 -0.0 0.2 0.3 1.9 -1.0 -0.5 0.2 -1.0 -0.9 -0.8 -1.6 1.1 0.3 0.5 0.0 1.1 1.1 -0.1 -0.9 -1.2
Leg fat percentage (right) 0.4 1.6 6.9 1.0 1.0 1.5 -1.4 0.6 0.8 0.8 2.6 -1.2 -0.1 0.9 -1.5 -0.6 -1.3 -1.6 1.7 0.9 1.3 0.6 1.5 1.9 0.5 -1.3 -1.3
Arm fat-free mass (right) 0.3 1.5 9.5 1.8 -1.6 -1.3 -0.5 0.7 0.7 0.3 0.6 0.2 1.2 1.0 -0.2 1.7 1.2 1.2 -3.1 0.7 1.4 0.7 -0.3 0.2 2.1 -0.2 1.2
Exposure to tobacco smoke outside home 0.7 0.9 7.0 -0.5 0.3 -1.0 0.4 0.2 -0.2 0.5 -1.0 2.6 -0.0 0.2 1.1 0.8 1.0 1.0 -0.9 -0.4 -0.3 -0.1 0.2 0.3 0.7 1.6 1.8
Comparative body size at age 10 0.3 0.8 2.3 0.7 1.4 -0.2 0.5 1.0 1.0 0.7 0.3 -0.1 1.0 1.5 -0.7 0.4 1.0 1.0 0.5 1.3 1.2 1.1 -0.9 0.2 1.0 -0.8 0.1
Number of full brothers 2.4 3.1 7.4 -1.7 1.7 2.1 -0.8 -2.0 -1.8 -2.2 0.2 -0.6 -2.0 -2.3 -0.9 -2.6 -2.6 -2.7 0.4 -1.6 -1.8 -2.0 -0.5 -0.4 -2.3 -0.6 -1.8
Worry too long after embarrassment 0.1 0.2 1.3 -0.2 0.2 0.1 0.3 0.1 -0.3 -0.1 -0.2 0.2 -0.4 -0.1 0.3 -0.5 -1.1 -0.8 -0.2 -0.3 -0.4 -0.5 0.2 0.0 0.2 0.5 0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 1.7 2.2 6.2 2.0 -0.7 0.1 -2.5 1.7 2.0 2.1 1.8 -1.5 -0.0 1.4 -1.9 -0.2 0.3 -1.3 1.6 1.6 1.6 1.8 0.6 1.8 1.0 -1.5 -1.3
Wheeze or whistling in the chest in last year 0.9 1.6 7.5 -1.6 -0.1 -0.7 0.3 -0.5 -1.9 -1.5 0.2 1.4 -0.1 -1.2 2.0 0.3 -0.1 0.9 1.1 -1.7 -1.0 -1.4 2.7 0.3 -0.2 2.2 1.5
Number of children fathered 0.9 1.1 5.4 -1.0 1.7 2.3 0.8 -1.1 -0.9 -0.8 0.6 -0.5 -0.7 -0.3 -1.0 -1.0 -0.9 -0.8 0.8 -1.1 -0.9 -1.3 -0.2 0.3 -1.3 -0.6 -1.3
Reason for reducing amount of alcohol drunk: Health precaution 3.0 3.5 8.8 -3.0 0.1 1.3 0.7 -2.8 -2.7 -2.4 -1.0 1.6 -1.5 -2.7 1.8 -1.5 -0.8 0.2 0.4 -2.7 -2.7 -2.5 0.6 -1.2 -2.5 2.0 0.3
Age at first live birth 0.2 0.4 2.1 -0.7 -0.5 -1.1 0.7 -0.2 -0.3 -0.1 -0.9 -0.1 0.6 0.4 1.2 0.3 0.5 0.5 0.5 -0.2 -0.2 -0.2 -0.2 -1.4 -0.1 0.4 0.5
Pulse wave peak to peak time 1.4 1.7 8.0 0.6 1.8 2.8 0.2 -0.7 0.5 0.1 2.3 -1.4 0.5 1.2 -2.4 -0.1 1.0 -0.3 1.4 0.7 0.6 0.5 0.1 1.6 0.1 -1.7 -1.9
Health satisfaction 0.8 1.0 3.3 0.8 1.8 1.0 0.8 0.7 0.7 0.8 1.7 -0.5 0.5 1.7 -0.9 -0.2 0.7 0.1 1.6 0.8 1.0 0.6 1.0 1.6 0.7 -0.6 -0.4
Shortness of breath walking on level ground 0.7 0.8 2.8 1.4 -0.4 -1.2 -1.7 1.2 1.3 1.1 0.1 -0.3 0.3 0.7 -0.2 0.3 -1.3 -0.2 0.3 1.3 1.2 1.5 0.4 0.5 1.1 -0.3 0.2
Qualifications: College or University degree 0.5 1.7 4.9 -1.7 0.2 -0.3 0.1 -1.3 -1.4 -1.4 -2.2 1.6 -1.4 -1.6 1.0 -1.3 0.3 0.2 -0.5 -1.6 -1.9 -1.4 -1.3 -1.2 -1.9 1.2 0.4
Eye problems/disorders: None of the above 1.6 1.9 4.4 1.7 -0.0 0.5 -0.9 1.4 1.9 1.9 1.6 -2.1 1.3 1.7 -1.5 0.7 0.0 0.4 0.6 1.8 1.9 1.9 -0.1 1.0 1.3 -1.5 -0.9
Mouth/teeth dental problems: Loose teeth 0.5 0.6 2.9 -0.8 0.4 -0.3 0.8 -0.8 -1.2 -1.3 -0.9 1.1 0.3 -0.7 0.5 0.6 -0.1 0.4 -1.7 -0.9 -0.6 -0.8 -0.5 -0.6 0.2 0.6 0.9
Emphysema/chronic bronchitis 0.6 0.7 4.7 -0.9 2.2 0.3 0.1 -0.7 -0.9 -0.8 -0.6 0.9 -1.0 -1.1 0.2 -1.0 -1.0 -0.6 0.6 -0.8 -0.9 -0.9 -0.0 -0.3 -1.0 0.1 -0.3
Medication for pain relief, constipation, heartburn 0.6 1.0 2.7 -1.0 -0.1 0.5 -1.4 -1.3 -0.8 -1.0 -0.5 -0.2 -1.4 -1.4 0.5 -1.6 -1.6 -1.5 -0.4 -0.9 -1.0 -0.7 -0.6 -0.9 -1.4 0.3 -0.4
Neck or shoulder pain in last month 1.0 1.4 4.4 0.9 -0.1 -1.6 -0.4 0.6 0.6 0.7 -0.3 1.9 1.0 1.3 0.1 2.1 1.4 1.5 -0.5 0.7 0.9 1.0 1.0 1.4 2.0 1.1 1.9
Medication: Blood pressure 0.7 1.2 5.7 -0.2 -0.0 2.4 -1.3 -0.6 0.1 -0.1 1.2 -1.4 -0.4 -0.5 -1.2 -1.2 -0.3 -1.0 1.9 -0.0 -0.1 -0.2 0.3 0.2 -1.3 -1.4 -2.2
Angina (self-reported) 0.3 0.4 2.5 0.2 -0.9 -0.2 -0.5 0.1 0.4 1.2 0.5 -0.1 0.4 0.5 -0.3 0.6 1.6 0.9 0.3 0.1 0.2 0.3 -0.7 -0.6 -0.1 -0.7 -0.5
Migraine (self-reported) 2.4 3.0 11.2 0.7 2.5 2.8 -0.9 0.4 0.9 1.1 2.6 -2.0 -0.3 0.7 -2.6 -1.3 -2.2 -2.2 3.3 0.7 0.6 0.2 0.5 1.8 -0.5 -1.7 -2.4
Medication: Ibuprofen 3.2 3.8 10.3 0.7 -0.6 -1.4 2.7 1.0 0.4 0.7 1.9 0.8 3.0 2.4 0.9 3.2 2.5 2.7 1.1 0.8 1.7 1.0 3.0 2.4 2.6 1.6 2.3
Medication: Allopurinol 2.5 3.4 10.4 -2.3 -0.3 0.8 2.4 -2.1 -2.6 -3.2 0.7 2.1 0.9 -1.4 2.0 1.1 2.0 1.6 1.1 -1.9 -1.5 -1.9 2.7 0.7 -0.1 2.8 1.6
Medication: Omeprazole 0.6 0.7 3.0 -0.3 1.5 1.7 1.0 -0.6 -0.5 -0.9 1.3 -1.3 0.1 0.5 -0.8 -0.6 0.7 -0.1 0.7 -0.4 -0.5 -0.5 0.8 1.1 -0.4 -0.2 -0.8
Medication: Seretide 50 evohaler 0.4 0.5 2.4 0.2 -0.1 -1.5 -0.4 0.7 0.2 0.1 -1.6 1.2 0.1 0.5 0.2 1.0 -0.5 0.3 -1.1 0.3 0.1 0.2 -1.1 -0.7 0.5 -0.1 0.7
Mean time to correctly identify matches 0.3 0.6 2.8 0.6 -0.4 0.9 0.5 0.3 0.6 0.6 1.5 -1.2 0.7 0.8 -0.9 0.2 0.1 0.6 1.7 0.7 0.9 0.6 0.2 0.3 0.6 -1.2 -0.7
Heart disease (mother) 0.6 0.7 1.7 0.7 -0.2 -0.1 0.6 0.7 0.8 1.3 0.8 1.2 1.2 0.7 -0.4 0.8 1.0 1.2 1.1 0.6 1.1 0.7 1.1 1.2 1.0 -0.5 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 4.8 5.7 15.1 3.1 0.2 -1.2 1.0 2.4 2.7 2.3 2.2 -2.1 3.7 3.9 -1.7 3.0 1.9 2.4 0.8 3.0 3.2 3.4 0.0 2.0 3.2 -1.2 0.1
Whole body fat mass 0.1 0.4 2.9 0.8 -0.1 0.9 -0.7 0.1 0.3 0.3 1.7 -0.8 0.1 0.3 -0.7 -0.0 -0.1 -0.8 -0.2 0.4 0.9 0.2 0.8 0.9 0.6 -0.7 -0.5
Leg fat mass (right) 0.2 0.8 4.6 1.1 0.0 0.8 -0.9 0.6 0.7 0.6 2.1 -0.8 0.5 0.8 -1.0 0.2 -0.5 -0.8 0.2 0.8 1.4 0.5 0.9 1.2 1.1 -1.0 -0.5
Arm predicted mass (right) 0.3 1.7 9.9 1.9 -1.7 -1.3 -0.5 0.8 0.8 0.5 0.7 0.1 1.4 1.2 -0.1 2.0 1.1 1.2 -3.1 0.8 1.6 0.8 -0.1 0.3 2.3 -0.1 1.3
Pulse rate, automated reading 0.4 1.2 10.0 0.6 3.2 0.3 1.8 0.9 0.5 0.7 1.0 0.0 0.9 1.1 -0.9 0.2 1.0 1.3 1.5 0.6 0.8 0.5 0.6 1.4 0.6 -0.6 -0.3
Alcohol intake frequency. 0.4 0.9 3.7 0.9 1.0 1.1 -0.7 0.3 0.6 0.5 1.2 -1.9 0.3 1.5 -1.5 0.3 -1.1 -0.4 0.2 0.9 0.7 0.8 -0.2 0.4 0.4 -1.5 -1.3
Comparative height size at age 10 0.4 2.1 15.4 -0.2 -1.8 -1.9 0.8 -0.9 -0.8 -1.0 -1.7 1.0 0.8 -1.1 1.8 1.7 1.0 1.4 -3.9 -0.6 -0.2 -0.4 -0.2 -1.0 1.0 1.4 2.4
Number of full sisters 0.7 0.8 3.4 -0.8 -1.1 -0.8 -0.5 -0.7 -0.7 -0.3 -1.2 1.8 -0.8 -1.6 1.4 -0.2 -0.0 -0.6 -0.7 -0.9 -0.8 -0.8 0.6 -0.3 -0.4 1.2 0.9
Suffer from ‘nerves’ 1.7 2.7 8.2 -0.8 1.6 2.4 -2.4 -0.9 -0.6 -0.5 0.5 -1.4 -2.2 -1.1 -1.7 -2.8 -2.2 -2.9 1.2 -0.9 -1.2 -1.5 -0.5 0.1 -1.9 -1.3 -2.3
Overall health rating 0.2 0.5 1.8 0.4 1.3 0.3 -0.1 0.4 0.0 -0.1 1.0 -0.1 0.2 1.3 -0.7 0.3 1.0 0.3 0.9 0.2 0.5 0.1 1.0 1.2 0.4 -0.5 -0.3
Chest pain or discomfort 0.4 0.6 2.5 -0.6 -0.4 -1.0 0.8 0.1 -0.9 -0.4 -0.2 1.6 0.5 0.1 0.5 1.3 0.3 1.1 -0.0 -0.9 -0.3 -0.9 0.8 0.3 0.4 1.1 1.1
Had major operations 0.7 0.8 3.7 -1.0 -0.2 -0.2 -0.4 -1.1 -1.2 -0.9 -0.6 1.9 -0.8 -0.8 1.1 -0.3 0.6 0.1 -0.9 -1.4 -1.0 -0.9 0.2 -0.7 -0.2 1.3 1.0
Age at last live birth 0.8 1.2 5.7 0.1 -0.0 -0.9 1.3 0.3 0.4 0.3 0.6 -0.5 2.4 1.2 0.6 1.5 2.1 2.4 1.5 0.9 1.1 0.7 0.6 -0.1 0.8 0.1 0.4
Family relationship satisfaction 0.1 0.2 0.8 0.1 0.2 -0.6 -0.8 -0.1 0.4 0.6 -0.1 0.0 0.0 0.2 0.1 -0.2 -0.1 -0.5 -0.3 0.3 0.3 0.2 0.6 0.9 0.5 0.5 0.5
Leg pain on walking 1.0 1.2 4.7 1.6 -0.6 -1.6 -0.2 2.2 1.4 0.7 -0.3 -0.4 1.0 1.1 -0.8 1.0 -0.4 1.2 -0.4 1.7 1.6 1.3 -0.6 0.5 1.4 -1.2 0.2
Qualifications: NVQ or HND or HNC or equivalent 3.1 3.8 10.3 2.2 -0.1 -0.2 1.2 2.5 2.4 2.8 1.8 -0.5 2.6 3.2 -1.3 2.1 1.3 1.8 0.9 2.3 2.6 2.2 1.2 2.5 2.7 -0.8 0.4
Commuting to job workplace: Car/motor vehicle 0.5 0.6 1.8 -0.8 0.7 0.8 -0.1 -1.3 -1.0 -0.7 0.5 0.8 -0.5 -1.2 0.1 -0.5 -0.1 -0.1 0.6 -1.3 -0.8 -1.2 0.8 0.6 -1.0 0.4 -0.3
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 2.4 -0.7 -0.1 0.2 0.0 -0.6 -0.4 -1.0 -0.9 0.5 -1.1 -1.6 0.3 -0.9 -1.0 0.2 0.4 -0.4 -0.7 -0.4 -0.7 -1.2 -1.1 -0.4 -0.5
Medication: Aspirin 0.4 0.5 1.7 0.7 -1.2 -0.7 -0.2 0.3 0.7 1.0 -0.9 0.6 0.7 -0.0 -0.1 1.2 0.7 1.3 -0.9 0.5 0.4 0.4 -0.5 -0.4 0.5 -0.7 0.1
Supplements: Vitamin C 2.8 3.3 10.6 -0.9 -1.7 -2.0 2.5 -0.2 -0.8 -0.5 -0.0 2.3 1.5 0.4 3.1 1.5 2.0 2.8 0.1 -0.7 -0.1 -0.4 3.2 0.7 1.2 3.2 3.3
Knee pain experienced in last month 1.6 2.4 7.1 1.9 0.5 0.6 -1.0 1.4 1.9 1.2 1.9 -1.8 0.9 2.7 -2.1 0.1 2.1 0.5 0.5 2.0 2.0 1.8 0.2 1.4 1.2 -2.2 -1.5
Hypertension (Self-reported) 0.4 1.0 5.0 0.1 0.3 1.6 -0.7 -0.1 0.1 0.0 1.2 -1.3 -0.6 -0.3 -1.4 -0.9 -0.5 -0.5 2.2 0.1 -0.1 0.1 0.6 0.8 -1.3 -1.0 -2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.2 4.9 0.4 2.2 1.9 -0.1 -0.0 0.5 -0.1 0.5 -1.3 -0.3 0.7 -2.2 -0.9 0.8 -0.8 0.5 0.6 0.0 0.5 -1.1 0.6 -0.8 -2.1 -2.0
Illnesses of father: Heart disease 0.7 1.0 4.0 0.3 -0.8 -1.2 1.0 0.0 0.1 -0.0 -1.3 1.2 1.1 0.8 0.8 2.0 1.1 1.6 -1.7 0.1 0.0 0.3 -0.2 0.3 0.6 1.4 1.6
Illnesses of siblings: Diabetes 0.4 0.5 1.4 -0.5 -0.4 -0.2 -1.2 -1.1 -0.9 -0.9 -0.4 0.9 -0.8 -1.2 -0.0 -0.3 1.1 0.2 0.0 -0.8 -0.9 -0.7 -0.3 -0.5 -1.0 0.0 -0.6
Smoking status: Previous 2.0 3.0 7.2 -2.2 -1.2 0.7 -0.3 -2.7 -2.5 -2.5 -1.0 1.9 -1.8 -2.2 2.0 -1.3 0.3 0.0 -0.6 -2.5 -2.3 -2.4 0.3 -1.4 -1.8 1.9 0.6
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.4 9.3 -0.1 -2.9 -2.7 1.0 -0.1 -0.7 -0.5 -2.1 2.0 0.0 -0.8 1.9 1.1 1.3 1.3 -3.0 -0.6 -0.4 -0.6 -0.7 -1.5 0.8 1.6 2.3
Whole body fat-free mass 0.4 2.0 13.9 1.6 -2.2 -1.8 -0.4 0.7 0.6 0.3 -0.0 0.5 1.3 0.8 0.3 1.9 1.7 1.6 -3.7 0.7 1.4 0.7 -0.7 -0.3 2.2 0.1 1.7
Leg fat-free mass (right) 0.3 1.4 11.2 1.3 -1.8 -1.3 -0.3 0.6 0.4 0.2 -0.3 0.4 0.9 0.5 0.1 1.3 1.7 1.3 -3.3 0.5 1.0 0.4 -1.2 -0.7 1.6 -0.1 1.1
Arm fat percentage (left) 0.4 1.6 6.0 1.1 0.9 1.7 -0.7 0.8 1.1 1.1 2.4 -1.8 0.1 0.9 -1.8 -0.6 -0.4 -1.3 1.6 1.1 1.3 0.8 0.8 1.6 0.5 -1.7 -1.6
Average weekly red wine intake 0.7 1.0 4.6 1.5 -1.5 -0.9 -0.2 1.0 1.1 0.5 0.3 -0.3 0.8 1.0 -0.3 1.1 0.7 2.1 -0.1 1.2 1.2 1.5 1.1 1.0 1.0 -0.4 0.1
Handedness (chirality/laterality): Left-handed 3.3 4.0 8.1 -2.4 -1.2 0.0 -1.1 -2.5 -2.6 -2.1 -2.0 1.8 -2.8 -2.4 2.0 -1.7 -1.6 -1.4 -1.2 -2.9 -2.8 -2.7 -0.1 -2.0 -2.2 1.9 0.6
Mood swings 0.2 0.3 2.9 -0.4 1.7 -0.3 0.4 0.9 0.2 0.7 -0.2 0.0 0.2 1.0 -0.4 0.2 -0.9 -0.7 -0.1 0.1 0.2 -0.1 -0.5 0.1 0.4 -0.1 0.1
Loneliness, isolation 0.5 0.7 3.8 -0.2 -0.0 -0.6 -1.1 0.4 -0.2 0.3 -0.9 0.2 -0.2 -0.2 0.5 -0.1 -1.9 -1.2 -1.8 -0.3 -0.1 -0.5 -1.4 -0.8 0.4 0.8 1.0
Long-standing illness, disability or infirmity 0.2 0.4 1.1 -0.2 -0.3 -1.0 -0.0 -0.1 -0.4 -0.7 -0.4 1.1 0.2 0.4 0.5 0.9 0.7 0.9 -1.0 -0.3 0.0 -0.1 -0.2 -0.0 0.4 0.8 1.0
Ever had bowel cancer screening 1.2 1.4 5.5 -1.7 0.8 0.7 2.3 -1.5 -1.8 -1.9 -0.2 1.3 -0.3 -0.2 0.8 -0.5 1.6 0.4 0.7 -1.4 -1.2 -1.8 0.2 -0.7 -1.0 0.5 0.1
Diabetes diagnosed by doctor 1.2 1.9 4.9 1.9 -1.3 -1.4 0.7 1.5 1.9 2.2 -0.0 -0.1 1.5 1.8 -0.4 1.8 1.8 1.7 -0.4 1.7 1.7 1.9 -0.4 0.6 1.6 -0.6 0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 2.7 -0.1 1.4 0.4 -0.8 -0.3 0.0 -0.1 0.2 -1.0 0.7 0.4 -0.9 0.3 1.7 0.7 0.2 0.2 0.0 0.3 0.1 0.5 -0.4 -0.7 -0.7
Friendships satisfaction 0.5 0.6 3.0 -0.5 1.7 0.7 -1.2 -0.3 -0.2 -0.3 -0.2 -0.2 -1.3 -0.7 -0.8 -1.4 0.1 -1.0 0.6 -0.3 -0.7 -0.3 -0.7 0.1 -0.9 -0.3 -0.7
Qualifications: nursing, teaching 0.9 1.3 4.6 0.9 -0.8 -0.9 1.3 0.5 1.0 0.4 0.4 0.3 1.8 1.6 0.2 1.6 2.1 1.9 -1.0 1.4 1.4 1.4 -0.0 0.4 1.7 0.0 0.9
Commuting to job workplace: Walk 0.3 0.3 1.0 -0.4 -0.9 -0.9 -0.3 0.3 -0.4 -0.3 -0.9 1.0 -0.2 -0.5 0.8 0.4 -0.4 0.6 -0.6 -0.2 -0.2 0.1 0.0 -0.6 0.1 0.6 0.7
Eye problems/disorders: Cataract 0.7 0.8 2.6 -1.1 0.4 -0.1 0.1 -0.4 -1.1 -1.2 -1.0 1.3 -1.6 -0.8 0.4 -0.9 0.1 -0.8 0.1 -1.1 -1.3 -1.2 -0.6 -0.8 -1.0 0.5 0.2
Mouth/teeth dental problems: Mouth ulcers 1.1 1.7 4.4 1.9 -0.0 -0.2 -1.1 2.1 1.9 1.7 0.7 -0.8 1.0 1.8 -2.0 1.2 -0.2 0.1 -0.8 1.8 1.6 1.4 -1.0 0.8 1.7 -1.6 -0.5
Medication for cholesterol 0.7 1.1 3.1 0.7 0.2 -1.5 0.1 1.3 1.3 1.1 -0.5 0.3 1.8 1.2 0.3 1.4 -0.1 0.8 -1.1 1.4 1.3 1.2 -0.8 -0.0 1.7 0.0 1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.6 -0.4 0.3 -0.5 -0.1 0.1 -0.4 -0.1 -0.2 0.2 -0.4 -0.4 0.1 -0.3 0.3 -0.2 -0.0 -0.5 -0.4 -0.4 -0.8 -0.7 -0.3 0.0 -0.0
Back pain experienced in last month 0.4 0.6 3.9 0.7 0.3 -0.8 0.8 0.5 0.3 -0.4 -0.2 0.6 0.3 1.6 -0.4 0.7 2.0 1.6 -0.9 0.6 0.4 0.4 -0.0 0.5 0.7 -0.2 0.3
Mineral and other dietary supplements 0.9 1.3 3.4 1.6 0.6 -0.6 -0.1 1.4 1.6 1.8 0.7 -0.7 1.0 1.0 -1.3 0.9 -1.0 -0.3 0.5 1.5 1.6 1.3 0.1 1.7 1.5 -0.7 0.0
Breast cancer (self-reported) 0.4 0.5 3.6 -0.8 1.6 1.0 -0.2 -0.5 -0.5 -0.7 0.8 -0.6 0.1 -1.0 -0.4 -0.5 -1.9 -0.4 0.3 -0.5 -0.3 -0.8 0.3 0.3 -0.2 0.0 -0.6
Asthma (self-reported) 0.2 0.4 1.8 -0.2 -0.3 -1.3 0.2 0.6 -0.4 -0.1 -0.2 0.8 0.3 0.3 1.2 0.6 -0.4 0.9 -0.3 -0.3 -0.0 -0.1 1.0 -0.4 0.5 0.9 0.9
Osteoporosis (self-reported) 0.6 0.7 2.4 -0.6 0.8 1.3 -0.7 -0.8 -0.4 -0.5 0.2 -0.1 -1.1 -0.6 -0.4 -1.4 0.0 -1.5 0.9 -0.6 -0.7 -0.7 -0.3 -0.6 -1.2 -0.8 -1.4
Osteoarthritis (self-reported) 0.8 1.0 2.7 -0.7 -1.4 -0.6 -0.7 -0.4 -1.0 -0.8 -1.0 1.7 -1.1 -1.6 0.8 -0.1 -0.9 -0.0 -1.6 -1.3 -1.1 -1.0 -0.4 -0.6 -0.4 1.4 1.0
Medication: Aspirin 0.4 0.6 2.4 0.5 -1.1 -0.7 -0.1 0.2 0.5 0.6 -1.2 0.7 0.7 0.2 0.1 1.3 1.1 1.5 -1.3 0.4 0.3 0.3 -0.9 -0.7 0.4 -0.5 0.3
Medication: Gliclazide 1.2 1.3 5.6 0.3 -0.8 -0.8 1.9 0.2 0.3 0.8 0.2 0.7 1.4 0.9 0.9 1.4 2.3 2.4 -0.2 0.2 0.6 0.6 1.6 1.1 1.0 1.0 1.3
Illnesses of father: None of the above (group 1) 0.7 0.8 3.4 -0.0 1.0 1.3 -0.2 0.0 0.1 0.2 1.5 -1.9 -0.3 -0.1 -0.7 -1.1 -1.1 -1.1 1.8 0.2 0.2 -0.0 0.0 -0.4 -0.4 -1.1 -1.4
Smoking status: Current 0.5 0.9 2.8 0.9 0.4 0.1 -1.0 0.8 0.8 1.0 1.3 -1.0 1.0 0.3 -1.0 0.9 -1.7 0.0 0.9 0.7 1.0 0.6 1.3 1.7 0.8 -0.6 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 4.2 -0.6 1.2 2.1 1.5 -1.0 -0.4 -0.3 0.8 -0.7 -0.0 -0.1 -0.8 -0.6 0.1 -1.0 0.5 -0.2 -0.4 -0.9 -0.8 -0.2 -0.6 -0.4 -0.8
Whole body water mass 0.4 2.0 13.2 1.7 -2.2 -1.7 -0.3 0.8 0.7 0.4 0.1 0.4 1.4 0.8 0.2 1.9 1.7 1.6 -3.6 0.7 1.4 0.8 -0.7 -0.2 2.2 0.0 1.6
Leg predicted mass (right) 0.2 1.3 11.4 1.2 -1.8 -1.2 -0.4 0.5 0.4 0.1 -0.3 0.4 0.8 0.4 0.1 1.2 1.6 1.2 -3.4 0.4 0.9 0.4 -1.2 -0.7 1.5 -0.1 1.1
Arm fat mass (left) 0.3 1.3 4.7 1.5 0.3 1.0 -0.6 0.9 1.2 1.1 2.2 -1.5 0.5 1.1 -1.5 0.1 0.1 -0.7 0.2 1.2 1.6 1.0 0.6 1.4 1.1 -1.5 -0.9
Number of self-reported non-cancer illnesses 0.6 1.0 4.8 0.8 0.6 0.2 -2.2 0.7 0.6 0.4 -0.0 -0.8 -1.3 0.2 -1.6 -0.7 -1.4 -1.4 0.4 0.4 0.2 0.4 -1.1 0.1 -0.6 -1.5 -1.6
Average weekly champagne plus white wine intake 0.2 0.3 2.5 -0.1 -0.1 -0.1 1.3 0.5 -0.2 0.1 0.3 0.9 0.5 0.5 0.3 0.8 1.6 0.9 0.5 -0.3 -0.1 -0.0 0.3 -0.0 0.0 0.2 0.3
Miserableness 0.5 1.0 3.5 -0.2 0.1 -1.9 -0.1 0.8 -0.0 0.5 -0.6 0.7 1.6 1.1 1.1 1.8 0.7 1.7 -0.0 -0.0 0.3 0.4 0.5 0.2 0.9 1.4 1.6
Guilty feelings 0.2 0.3 1.5 -0.6 1.2 1.0 0.3 -0.8 -0.6 -0.3 0.4 -0.4 -0.3 -0.3 -0.1 -1.0 -0.2 -0.4 0.8 -0.6 -0.5 -0.8 0.4 0.2 -0.4 0.1 -0.2
Wears glasses or contact lenses 0.6 0.7 3.0 0.8 0.5 0.3 0.4 0.8 1.0 0.7 0.2 -0.7 0.4 1.3 -0.9 0.2 0.0 -0.6 -0.3 1.1 0.9 1.0 -1.7 -0.6 0.5 -1.3 -0.7
Ever taken oral contraceptive pill 0.4 0.5 3.3 0.5 -0.0 0.1 -1.8 0.4 0.5 0.3 -0.3 -0.6 -0.6 0.5 -1.1 -0.2 0.1 -0.7 -0.6 0.1 0.0 0.1 -1.3 -0.6 -0.2 -1.2 -1.0
Hearing aid user 0.3 0.3 1.6 -0.1 1.3 0.5 0.7 0.3 -0.1 -0.2 0.8 -0.1 0.1 0.2 -0.6 -0.3 1.3 0.4 0.8 0.1 0.2 0.5 0.5 0.8 0.2 -0.2 -0.2
Mother’s age at death 0.3 0.3 3.9 -0.3 0.4 0.1 2.0 -0.3 -0.4 -0.4 -0.4 0.2 0.8 0.0 0.3 0.5 -1.0 0.4 -0.4 -0.1 -0.0 -0.4 0.2 0.2 0.3 0.6 0.7
Financial situation satisfaction 0.6 0.7 3.7 -0.5 1.9 1.6 -0.1 -0.6 -0.5 -0.8 0.8 -0.2 -1.2 -0.4 -0.7 -1.4 -0.8 -1.6 0.6 -0.3 -0.5 -0.6 0.1 0.5 -0.6 -0.2 -0.8
Tinnitus: Yes, now most or all of the time 0.6 0.7 2.6 1.1 0.9 0.5 0.3 1.0 0.8 1.0 1.0 -0.8 0.3 1.0 -1.6 0.4 -0.3 -0.4 0.2 0.7 0.9 0.5 -0.9 0.6 0.8 -1.2 -0.7
Commuting to job workplace: Public transport 0.2 0.2 0.8 -0.5 -0.2 0.6 0.7 -0.3 -0.3 -0.3 -0.5 -0.1 -0.0 -0.2 0.1 -0.0 -0.1 -0.5 0.0 -0.4 -0.5 -0.6 -0.7 -0.9 -0.7 -0.3 -0.5
Eye problems/disorders: Glaucoma 1.0 1.1 3.5 -1.9 0.5 -0.2 0.0 -1.2 -1.4 -0.6 -1.1 1.5 -0.5 -1.3 1.6 -0.3 0.5 0.3 0.3 -1.6 -1.5 -1.4 0.7 -0.7 -1.3 1.2 0.7
Medication: Blood pressure 0.4 0.8 2.3 -1.0 -0.5 0.2 0.1 -1.0 -1.4 -1.2 -0.2 0.0 -0.7 -0.9 0.7 -0.3 1.3 0.4 0.4 -1.5 -1.3 -1.3 1.1 -0.2 -1.4 0.6 -0.4
Pain type(s) experienced in last month: Hip pain 2.2 2.8 7.5 2.1 -0.6 -0.8 1.1 2.2 1.9 0.8 2.2 -0.5 2.2 2.7 -1.2 2.1 1.6 1.4 -0.4 2.1 2.5 1.9 -0.5 0.9 2.6 -1.2 0.1
Supplements: Fish oil (including cod liver oil) 0.3 0.3 1.2 -0.7 -0.4 0.4 0.6 -0.6 -0.8 -0.8 -0.4 0.6 -0.4 -0.7 0.6 -0.3 1.1 0.1 -0.0 -0.6 -0.8 -0.5 -0.1 -0.9 -0.7 0.3 0.1
High cholesterol (Self-reported) 1.6 2.8 8.8 1.3 0.4 2.0 1.4 0.5 1.1 0.7 2.9 -1.6 1.2 0.8 -2.4 0.6 2.7 1.0 3.0 1.4 1.4 0.9 1.5 2.4 0.5 -2.2 -2.2
Medication: Bendroflumethiazide 0.2 0.3 1.8 -0.3 -0.9 -0.0 -0.1 -0.4 -0.7 -0.7 0.2 0.8 -0.1 -0.4 0.5 0.4 0.6 0.8 -0.6 -0.9 -0.3 -0.5 1.3 0.4 -0.1 0.6 0.2
Medication: Paracetamol 0.3 0.5 2.0 0.2 0.0 0.2 0.7 0.5 0.2 0.6 1.3 -0.3 0.4 1.1 -0.1 -0.0 1.4 0.3 1.1 0.2 0.4 0.1 1.4 1.3 0.7 0.6 0.3
Medication: Lisinopril 0.4 0.5 1.6 0.8 1.0 1.1 -0.5 0.2 0.7 0.2 0.8 -1.0 0.1 0.8 -1.3 -0.1 0.1 0.1 0.4 0.8 0.6 0.6 -0.5 0.7 0.0 -0.9 -1.0
Medication: Atorvastatin 2.6 3.3 9.1 2.2 0.0 1.2 -0.4 1.8 2.4 2.2 1.9 -2.2 1.8 3.0 -2.7 1.5 1.0 -0.2 1.1 2.2 2.1 1.6 -1.0 0.9 1.6 -2.6 -1.7
Illnesses of father: High blood pressure 1.4 1.7 4.9 1.4 0.7 0.5 -0.0 1.7 1.6 1.4 1.6 -0.8 0.9 1.2 -1.7 0.6 0.1 0.3 1.4 1.7 1.8 2.2 0.7 2.2 1.3 -1.2 -0.6
Alcohol drinker status: Never 0.9 1.1 2.7 1.3 -0.7 -0.5 0.5 1.6 1.1 0.8 1.3 -0.9 1.3 1.6 -0.4 1.3 0.1 1.0 0.9 1.5 1.5 1.4 0.8 0.3 1.2 -1.0 -0.4
Ever smoked 0.4 0.7 2.4 -0.9 -0.8 0.4 -0.9 -1.3 -1.1 -1.0 0.2 0.8 -0.4 -1.6 0.8 -0.1 -0.4 0.7 -0.0 -1.3 -0.8 -1.3 1.1 0.1 -0.5 1.0 0.4
Basal metabolic rate 0.3 1.5 10.2 1.6 -1.9 -1.3 -0.5 0.7 0.7 0.4 0.4 0.1 1.1 0.7 -0.0 1.6 1.3 1.1 -3.2 0.7 1.4 0.7 -0.5 -0.1 2.0 -0.2 1.2
Leg fat percentage (left) 0.4 1.4 7.2 0.8 1.1 1.7 -0.9 0.3 0.5 0.5 2.7 -0.9 0.1 0.7 -1.3 -0.5 -1.0 -1.4 1.7 0.7 1.1 0.3 1.7 1.9 0.4 -1.0 -1.2
Arm fat-free mass (left) 0.3 1.7 8.4 1.9 -1.5 -1.1 -0.6 0.9 1.0 0.6 0.9 -0.0 1.4 1.2 -0.4 1.8 1.2 1.1 -2.9 1.1 1.8 1.0 -0.4 0.2 2.3 -0.4 1.0
Number of operations (self-reported) 0.7 1.0 5.3 0.9 0.8 -0.9 -1.3 1.4 0.7 0.5 -0.7 0.6 -0.4 1.4 -1.2 0.7 0.0 -0.4 -1.8 0.6 0.6 0.9 -2.3 -0.5 1.1 -1.0 0.2
Average weekly beer plus cider intake 0.2 0.3 1.3 -0.3 -0.5 -0.6 0.5 -0.2 -0.4 -0.2 -0.7 0.3 0.2 0.3 0.7 0.0 1.1 0.1 -0.5 -0.3 -0.4 -0.5 -0.8 -1.1 -0.2 0.5 0.5
Irritability 0.6 1.0 4.2 -0.9 1.4 -1.3 0.1 0.0 -0.6 -0.7 -2.0 2.0 -0.4 0.1 0.9 0.4 -1.0 -0.2 -1.1 -0.6 -0.7 -0.5 0.0 0.1 0.3 1.5 1.5
Risk taking 0.6 0.9 3.4 0.5 0.7 1.1 -1.8 -0.2 0.6 0.5 1.9 -1.2 0.6 0.5 -1.6 0.2 -0.8 -0.7 0.6 0.4 0.7 0.4 0.9 1.7 0.5 -0.9 -0.9
Ever had prostate specific antigen (PSA) test 1.4 1.6 4.1 -1.8 0.1 -0.0 -0.4 -1.6 -1.8 -1.6 -1.1 1.4 -1.4 -2.0 1.6 -1.1 0.0 -0.4 -0.4 -1.7 -1.6 -1.7 1.2 -0.8 -1.4 1.1 0.5
Fractured/broken bones in last 5 years 0.4 0.6 2.3 -0.0 0.3 -1.3 -0.0 0.3 -0.1 -0.5 -0.3 1.0 0.3 0.3 0.8 0.5 0.9 1.0 -1.3 -0.1 0.3 0.3 0.4 0.8 0.7 1.5 1.5
Age started oral contraceptive pill 0.3 0.4 2.0 -0.2 -0.5 0.0 0.1 -0.8 -0.6 -0.9 -0.5 1.0 -0.4 -0.8 0.6 -0.5 -0.4 -0.2 -1.4 -0.6 -0.4 -0.6 0.7 0.3 -0.2 0.7 0.6
Diastolic blood pressure, automated reading 1.3 4.0 9.1 2.4 -0.9 -1.4 1.4 2.8 2.5 2.2 1.9 -0.2 2.4 2.3 -0.6 2.2 2.0 2.4 1.6 2.6 3.0 2.9 0.9 1.6 2.5 -0.9 0.4
Ever depressed for a whole week 0.3 0.3 1.0 0.6 -0.3 -0.7 -0.8 0.3 0.5 0.3 0.2 0.5 0.4 0.4 -0.1 0.9 0.6 0.8 -0.6 0.5 0.9 0.8 -0.5 -0.0 1.0 -0.2 0.5
Unable to work because of sickness or disability 1.0 1.3 5.7 1.1 0.3 0.8 -1.0 0.9 1.0 1.0 2.4 -1.7 0.4 0.8 -1.2 -0.3 -0.5 -0.4 1.7 0.7 1.1 1.0 1.7 1.7 0.7 -1.0 -1.0
Commuting to job workplace: Cycle 0.3 0.4 1.6 -0.3 0.6 0.8 -0.6 -0.1 -0.3 -1.1 -0.2 -1.3 -0.1 0.4 -0.8 -0.2 0.4 -0.4 -0.5 -0.1 -0.3 -0.2 -1.0 -0.6 -0.8 -0.9 -1.1
Myopia 0.3 0.4 3.2 0.6 -1.8 -0.1 0.4 -0.1 0.3 0.5 1.0 -0.8 0.5 0.4 0.4 0.0 1.6 0.4 0.2 0.1 0.2 0.2 0.4 -0.6 0.3 0.2 -0.3
Vascular/heart problems diagnosed by doctor 0.3 0.8 3.6 0.2 0.0 -1.5 0.9 0.4 0.3 0.0 -0.7 0.8 0.9 0.6 1.1 1.0 0.5 0.8 -1.5 0.5 0.6 0.5 0.2 -0.1 1.5 0.7 1.9
Cholesterol lowering medication 1.0 1.5 7.1 -0.2 0.7 2.7 1.0 -1.6 -0.9 -1.2 2.1 -0.6 -0.7 -1.0 -1.1 -1.0 0.9 -0.2 1.6 -0.9 -0.6 -1.1 1.3 1.2 -1.1 -0.3 -1.6
Medication: Omeprazole (e.g. Zanprol) 1.2 1.4 5.2 -1.2 1.8 2.3 1.3 -1.3 -1.3 -1.4 1.0 -0.7 -0.5 -0.2 -0.4 -1.2 1.4 -0.2 1.1 -1.3 -1.4 -1.3 1.1 0.8 -1.3 0.3 -0.8
Pain experienced in last month 0.2 0.4 4.1 -0.3 -0.6 -0.0 0.1 0.2 0.0 0.5 -0.1 -1.1 0.1 -1.0 -0.1 -0.2 -2.0 -0.3 0.2 -0.1 -0.1 -0.3 -0.8 -0.6 -0.3 -0.4 -0.3
Supplements: Calcium 2.1 2.3 6.5 -2.0 2.4 2.1 -0.7 -1.8 -1.5 -1.8 -0.6 -0.2 -1.8 -1.0 0.1 -2.3 0.3 -1.0 0.2 -1.6 -2.0 -1.8 -1.0 -1.4 -2.6 -0.1 -1.4
Basal cell carcinoma (self-reported) 1.0 1.2 4.5 0.8 1.4 1.1 -0.6 0.7 0.9 0.9 2.1 -1.1 0.3 0.6 -2.0 -0.0 -0.5 -0.7 1.5 0.8 1.0 0.8 0.0 1.2 0.6 -1.6 -1.3
Heart attack/myocardial infarction (self-reported) 1.2 1.5 8.3 -0.3 -1.2 -0.6 1.7 -0.2 -0.5 -0.1 -0.5 1.3 1.3 1.0 1.1 1.7 2.9 2.4 -0.1 -0.5 -0.3 -0.1 1.3 0.8 0.5 1.6 1.6
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 2.8 0.1 0.8 0.3 -1.6 0.1 0.2 0.1 -0.9 -0.2 -0.8 -0.5 -0.7 -0.4 -0.7 -1.0 -0.5 0.0 -0.2 0.2 -1.7 -0.6 -0.6 -0.8 -0.5
Heart disease (siblings) 1.2 1.4 4.5 1.1 -0.1 0.9 0.6 0.8 1.1 1.2 2.1 -1.6 1.6 1.6 -1.4 0.8 0.7 0.9 1.4 1.1 1.3 1.1 0.5 0.8 0.8 -1.7 -1.3
Alcohol drinker status: Previous 1.0 1.2 4.6 1.4 0.3 -0.9 -1.2 1.6 1.6 2.1 0.1 -1.3 0.9 1.4 -1.0 1.0 -0.6 0.0 0.1 1.2 1.1 1.2 -0.8 0.3 0.7 -1.0 -0.5
Pack years of smoking 1.4 2.1 4.5 -1.6 1.5 0.8 -1.6 -1.3 -1.5 -1.5 -1.2 -0.2 -2.1 -1.9 0.3 -2.1 -2.1 -1.9 -0.6 -1.6 -1.7 -2.1 0.6 -0.6 -1.7 0.0 -0.6
Impedance of whole body 1.2 6.0 15.0 -3.4 -0.3 -0.4 0.3 -3.2 -3.3 -2.9 -3.0 2.2 -2.3 -3.9 3.0 -1.6 -1.1 -0.9 -0.3 -3.3 -3.6 -2.9 0.9 -1.6 -2.9 3.0 1.2
Leg fat mass (left) 0.1 0.6 3.6 0.9 -0.0 0.8 -0.8 0.4 0.5 0.3 1.9 -0.6 0.3 0.6 -0.8 0.1 -0.4 -0.7 0.0 0.6 1.2 0.3 0.9 1.1 0.9 -0.8 -0.4
Arm predicted mass (left) 0.3 1.6 7.3 1.9 -1.4 -1.1 -0.3 0.8 0.9 0.5 1.1 0.1 1.4 1.2 -0.3 1.7 1.5 1.2 -2.7 1.0 1.7 0.9 -0.2 0.4 2.4 -0.2 1.2