TWAS hub - C4orf36

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Caudate basal ganglia	0.2540	0.1010	1.8e-03	0.011	NA	0.089	NA	0.039	1.5e-01	NA	1.6e-03	NA	2.8e-02
2	GTEx	Lung	0.0764	0.0323	4.4e-04	0.058	NA	0.041	NA	0.041	3.2e-05	NA	4.3e-04	NA	4.1e-04
3	GTEx	Testis	0.2100	0.0750	2.2e-04	0.147	NA	0.138	NA	0.143	4.6e-07	NA	1.1e-06	NA	6.6e-07
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0242	0.0141	9.9e-03	0.011	0.008	0.005	NA	0.007	1.8e-02	0.0370	7.4e-02	NA	5.3e-02
5	TCGA	Brain Lower Grade Glioma	0.0470	0.0250	6.2e-05	0.033	0.022	0.017	NA	0.024	1.1e-04	0.0014	4.2e-03	NA	9.1e-04
6	TCGA	Prostate Adenocarcinoma	0.0599	0.0396	5.6e-03	0.014	0.016	0.016	NA	0.013	1.2e-02	0.0073	7.4e-03	NA	1.5e-02
7	TCGA	Thyroid Carcinoma	0.0330	0.0190	5.5e-03	0.006	0.020	0.010	NA	0.005	7.1e-02	0.0041	3.3e-02	NA	1.0e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Hypothyroidism (self reported)	5.2	11.9	26.8	5.2	1.2	1.6	3.9	2.6	4.2	3.6
Risk taking	4.9	7.1	11.9	-0.0	-3.4	-1.9	3.4	3.0	1.6	3.3
Primary Biliary Cirrhosis	4.7	6.7	10.7	1.8	-2.5	-1.8	3.3	2.9	2.3	3.1
Schizophrenia vs Biploar Disorder	4.5	5.9	13.6	1.0	-0.8	-2.0	3.1	3.7	1.5	3.2
Worrier / anxious feelings	4.2	7.9	14.9	-0.8	2.9	1.8	-3.9	-3.3	-2.2	-3.5
Pulse rate	4.2	7.0	13.2	-1.4	1.9	1.1	-3.6	-3.4	-2.3	-3.5
Triglycerides	3.3	5.4	18.8	3.2	2.8	4.3	0.5	-0.6	-0.3	0.3
Hearing difficulty/problems with background noise	3.3	5.3	17.1	-0.6	-2.1	-0.4	2.6	1.5	4.1	2.3
Blood Red Count	2.9	28.2	57.0	-5.5	2.3	-1.6	-7.5	-6.0	-3.4	-7.4
Mouth/teeth dental problems	2.8	4.2	9.2	-1.4	0.4	-0.7	-2.9	-1.6	-3.0	-2.6
Breastfed as a baby	2.8	3.5	6.7	0.3	-1.6	-1.6	2.4	2.6	0.6	2.5
Back pain experienced in last month	2.8	4.1	7.6	-0.8	2.6	2.0	-2.0	-2.8	0.3	-2.3
Hypothyroidism/myxoedema (self-reported)	2.7	5.2	15.8	4.0	1.5	1.6	2.2	1.3	2.3	2.1
Neuroticism (2016)	2.5	3.6	8.1	1.0	2.5	2.8	-1.5	-2.3	0.2	-1.6
Heel bone mineral density (BMD) T-score, automated (left)	2.5	5.7	16.6	2.6	2.5	4.1	-1.2	-2.6	0.7	-1.2
Pulse wave peak to peak time	2.4	2.8	5.1	1.7	0.0	0.8	2.3	1.4	2.2	2.1
Supplements: Zinc	2.2	2.4	4.5	-0.7	-1.1	-0.6	2.1	1.8	1.6	2.1
Medication: Ramipril	2.2	2.8	6.0	2.0	-1.0	-0.4	2.0	1.9	1.2	2.4
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.6	3.8	1.7	-1.2	-1.5	1.5	1.7	1.9	1.6
Smoking status: Previous	2.2	3.2	6.2	0.4	-1.4	-1.4	2.3	2.5	1.4	2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.2	2.6	4.5	-0.4	2.1	1.4	-1.9	-2.0	-0.4	-2.0
Medication: Levothyroxine sodium	2.1	3.6	11.2	3.3	1.0	1.0	1.9	1.2	1.9	1.7
Heel bone mineral density (BMD) T-score, automated (right)	2.1	4.9	14.1	2.8	1.9	3.8	-1.2	-2.4	0.6	-1.1
Medication: Allopurinol	2.1	2.8	7.5	2.7	0.4	-0.1	1.8	1.8	1.4	1.9
HDL Cholesterol	2.0	3.4	14.3	-1.7	-2.3	-3.8	-0.8	0.5	-0.6	-0.7
Ulcerative Colitis	2.0	2.9	7.5	-1.3	-2.7	-2.3	1.1	1.8	-0.8	1.0
Heel T-Score	2.0	15.6	49.3	3.5	4.6	7.0	-2.2	-3.6	-2.2	-2.1
Smoking Status	2.0	4.7	6.9	0.8	-2.5	-0.7	2.6	2.4	2.6	2.5
Medication: Aspirin	2.0	2.6	4.9	-0.1	-2.2	-0.6	1.9	1.5	1.8	1.9
Schizophrenia (2018)	1.9	4.0	6.7	1.6	-1.1	-2.6	2.2	2.5	0.6	2.4
Knee pain experienced in last month	1.9	3.0	7.1	0.7	2.7	1.8	-1.7	-2.0	-0.4	-1.7
Medication: Aspirin	1.8	2.3	4.2	0.5	-2.1	-0.6	1.8	1.4	1.7	1.8
Ever smoked	1.8	3.2	4.4	1.2	-2.1	-1.3	2.1	1.8	1.8	2.0
Impedance of leg (right)	1.7	8.4	18.1	-1.8	-4.2	-3.9	1.9	3.3	-1.2	2.4
Pulse wave Arterial Stiffness index	1.7	1.9	3.4	-1.4	-0.1	-0.9	-1.8	-1.1	-1.7	-1.8
Gout (self-reported)	1.7	2.4	5.6	2.4	0.7	0.4	1.7	1.7	1.0	1.9
Illnesses of siblings: Diabetes	1.7	2.1	5.6	-0.0	-2.0	-2.4	1.1	1.6	0.3	1.1
Heart attack/myocardial infarction (self-reported)	1.7	2.1	6.8	-0.3	-1.0	0.8	1.9	0.7	2.6	1.6
Impedance of leg (left)	1.6	8.0	15.3	-1.4	-3.9	-3.7	2.0	3.5	-1.2	2.6
Time employed in main current job	1.6	1.9	3.5	-1.8	-1.9	-1.6	0.9	1.4	-0.7	0.9
Lung cancer (father)	1.6	1.8	4.9	2.2	1.0	1.6	-0.9	-1.7	-0.0	-0.9
Mouth/teeth dental problems: Loose teeth	1.6	1.9	8.1	0.6	-0.4	0.4	1.5	0.7	2.9	1.2
Leg pain on walking	1.6	2.0	3.0	-1.1	1.1	0.8	-1.6	-1.7	-1.7	-1.6
Average weekly champagne plus white wine intake	1.6	2.3	5.0	0.7	1.3	1.3	-1.7	-2.2	0.6	-1.9
Medication: Atorvastatin	1.6	2.0	7.3	2.7	0.5	2.1	1.1	0.0	0.3	1.0
Mean Putamen Volume	1.5	1.7	4.8	2.2	-0.1	1.5	0.8	-0.2	2.1	0.5
Schizophrenia (2014)	1.5	3.3	6.3	0.6	-1.0	-2.2	2.1	2.5	0.2	2.4
Heart attack	1.5	1.9	6.9	-0.4	-0.9	0.8	1.6	0.4	2.6	1.3
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	3.3	0.2	-1.4	-1.1	1.8	1.8	0.9	1.8
Impedance of arm (right)	1.5	7.2	16.3	-2.6	-4.0	-4.0	1.3	2.5	-0.9	1.7
Pulse rate, automated reading	1.5	4.8	9.2	-0.9	2.2	0.4	-3.0	-2.6	-1.7	-3.0
Diastolic blood pressure, automated reading	1.5	4.6	11.3	-3.4	-0.1	-1.8	-2.0	-0.6	-3.1	-1.8
Severe depression (siblings)	1.4	1.5	2.4	1.1	-0.5	-1.2	1.3	1.5	1.5	1.3
Neck or shoulder pain in last month	1.4	1.9	4.4	-0.3	-1.2	-1.0	1.6	1.3	2.1	1.5
Medication: Blood pressure	1.4	2.5	5.2	1.3	-1.4	-0.2	2.3	1.8	1.1	2.2
Angina (self-reported)	1.4	1.8	5.7	-1.1	-2.4	-1.5	1.1	0.5	1.1	1.0
Pain type(s) experienced in last month: Hip pain	1.4	1.7	4.4	-1.2	0.9	2.1	-0.7	-1.9	-0.1	-1.1
Impedance of whole body	1.4	7.3	15.5	-1.8	-3.9	-3.8	1.6	3.0	-1.3	2.2
Blood Platelet Count	1.3	15.2	31.7	-2.1	2.1	0.4	-5.6	-4.4	-5.0	-4.7
Past tobacco smoking	1.3	2.5	4.0	-0.5	1.5	1.2	-1.9	-1.9	-1.4	-2.0
Alcohol intake versus 10 years previously	1.3	2.0	3.4	0.4	-1.5	-1.0	1.8	1.7	1.1	1.7
Impedance of arm (left)	1.3	6.2	14.2	-2.1	-3.6	-3.8	1.2	2.5	-1.2	1.7
Illnesses of father: Heart disease	1.3	1.9	3.2	0.6	-1.4	0.2	1.8	1.3	1.8	1.5
Ever depressed for a whole week	1.3	1.6	3.2	-0.0	-0.3	-1.4	1.6	1.8	0.8	1.6
Had other major operations	1.2	1.5	2.3	-1.4	1.5	0.5	-1.5	-1.1	-0.4	-1.4
Loud music exposure frequency	1.2	1.4	2.3	1.3	0.4	0.8	1.4	0.9	1.5	1.4
Age at first live birth	1.2	2.0	5.6	-1.6	-1.6	-1.8	-0.4	0.3	-2.4	-0.0
Number of operations (self-reported)	1.2	1.7	4.8	0.3	2.2	1.4	-1.0	-1.1	1.1	-1.4
Arm predicted mass (left)	1.2	6.1	12.7	1.7	3.5	3.6	-0.9	-2.4	2.5	-1.6
Alzheimer’s Disease (in father)	1.1	1.2	2.4	0.1	-1.1	-1.2	0.9	1.5	-0.9	1.2
Fasting Glucose	1.1	1.3	3.1	-1.4	1.2	0.7	-0.9	-0.9	-1.8	-0.8
Fed-up feelings	1.1	1.9	4.0	0.4	2.0	1.8	-1.4	-1.7	-0.3	-1.2
Illnesses of siblings	1.1	1.6	2.3	-1.3	0.9	1.4	-1.4	-1.5	-0.7	-1.3
Falls in the last year	1.1	1.4	2.3	-0.3	1.1	1.4	-1.3	-1.5	-1.0	-1.3
Happiness	1.1	1.3	4.2	-0.5	-1.0	-1.3	0.7	1.0	-2.0	0.9
Mouth/teeth dental problems: Dentures	1.1	1.9	7.3	0.2	-0.2	0.8	1.7	0.6	2.7	1.4
Length of working week for main job	1.1	1.2	2.9	0.4	1.3	1.7	-0.6	-1.5	0.9	-0.7
Birth weight of first child	1.1	2.0	3.9	0.5	2.0	1.7	-1.0	-1.7	1.1	-1.4
Headache pain in last month	1.1	2.0	3.2	1.8	0.7	0.5	1.7	1.8	-0.6	1.8
Arm fat-free mass (right)	1.1	5.6	11.5	1.8	3.3	3.4	-0.5	-2.0	2.8	-1.2
Comparative body size at age 10	1.1	3.0	6.7	0.1	1.9	1.9	-1.6	-2.6	0.5	-2.1
Arm predicted mass (right)	1.1	5.8	11.8	2.1	3.4	3.4	-0.3	-1.8	2.9	-1.0
Leg fat-free mass (right)	1.1	5.7	13.3	1.4	3.6	3.2	-1.0	-2.4	2.1	-1.7
Bipolar Disorder (2011)	1.0	1.0	1.8	-0.6	1.0	0.3	-1.3	-1.1	-0.6	-1.3
Blood Eosinophil Count	1.0	7.4	15.3	-1.4	1.7	0.7	-3.9	-3.6	-1.8	-3.9
Lung FVC	1.0	4.9	8.9	2.6	-2.1	1.2	2.9	2.0	0.8	3.0
Sensitivity / hurt feelings	1.0	1.8	6.9	0.9	2.6	1.7	-0.8	-0.9	0.2	-0.6
Systolic blood pressure, automated reading	1.0	2.9	8.1	-1.0	0.5	-0.2	-2.2	-1.3	-2.8	-2.0
Leg fat-free mass (left)	1.0	5.4	12.0	1.2	3.5	3.2	-1.0	-2.4	2.3	-1.7
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	3.0	0.2	1.6	1.7	-0.6	-1.0	0.3	-0.7
Leg predicted mass (left)	1.0	5.4	12.3	1.1	3.5	3.2	-1.0	-2.4	2.2	-1.7
Trunk fat-free mass	1.0	5.8	10.8	1.8	3.0	3.1	-0.8	-2.3	3.3	-1.5
Hair/balding pattern: Pattern 3	1.0	1.4	3.0	0.8	-1.7	-1.0	1.4	0.7	1.1	1.4
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	3.5	1.3	1.9	0.7	0.5	0.6	1.3	0.4
Trunk predicted mass	1.0	5.7	10.2	1.8	3.0	3.1	-0.8	-2.4	3.2	-1.5
Age at last live birth	1.0	1.4	3.9	-0.8	-1.1	-1.8	-0.9	-0.1	-2.0	-0.4
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	5.6	0.7	2.4	1.4	-0.4	-0.4	-0.1	-0.3
Whole body fat-free mass	1.0	5.8	10.6	1.6	3.3	3.2	-0.8	-2.3	3.0	-1.5
Ever had bowel cancer screening	1.0	1.1	3.1	1.1	1.2	0.8	-0.6	-0.9	-1.8	-0.5
Whole body water mass	1.0	5.8	10.4	1.7	3.2	3.2	-0.7	-2.3	3.1	-1.4
Leg predicted mass (right)	1.0	5.6	12.8	1.5	3.6	3.2	-0.9	-2.2	2.3	-1.6
Illnesses of father: High blood pressure	1.0	1.2	3.1	-0.7	0.9	-1.6	0.7	1.8	-0.4	0.9
Basal metabolic rate	1.0	5.5	11.2	1.6	3.3	3.2	-0.7	-2.2	2.6	-1.4
Arm fat-free mass (left)	1.0	5.2	10.9	1.7	3.1	3.3	-0.5	-2.0	2.8	-1.2
Ulcerative Colitis (UC)	0.9	1.6	2.7	-1.1	-1.6	-0.9	1.3	1.5	-1.1	1.2
Coronary Artery Disease (CAD)	0.9	1.1	2.9	0.2	-0.4	-0.8	1.4	1.7	0.3	1.3
Lupus	0.9	1.3	2.6	1.1	-1.2	-1.1	1.2	1.1	-0.4	1.6
Chronotype (morning person)	0.9	2.0	2.7	0.6	1.6	1.6	-1.3	-1.4	-1.5	-1.4
Angina	0.9	1.2	3.6	-0.9	-1.9	-1.1	0.8	0.3	1.1	0.7
Current tobacco smoking	0.9	1.5	3.2	0.8	-1.5	-0.6	1.2	1.0	1.8	1.2
Taking other prescription medications	0.9	1.3	3.3	1.8	1.5	1.3	0.7	0.2	1.1	0.7
Hayfever, allergic rhinitis or eczema	0.9	2.0	6.4	0.7	2.5	2.3	-0.4	-1.0	0.3	-0.4
Blood clot in the leg (DVT)	0.9	1.2	1.7	1.3	0.2	-0.9	1.1	1.3	1.2	1.1
Medication: Paracetamol	0.9	1.4	2.3	0.3	1.5	1.2	-1.2	-1.3	-1.5	-1.1
Medication: Ibuprofen	0.9	1.1	5.0	-2.2	-0.7	0.9	-0.4	-0.8	-0.5	-0.4
Tinnitus: Yes, now most or all of the time	0.9	1.1	6.6	-0.3	0.4	2.6	0.3	-0.6	0.5	0.0
Commuting to job workplace: Public transport	0.9	1.1	4.4	2.1	0.5	0.1	0.9	0.9	0.6	0.9
Cholesterol lowering medication	0.9	1.3	3.9	1.6	0.4	2.0	1.2	0.1	0.6	0.8
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	1.6	1.2	0.2	-0.8	1.2	1.3	1.2	1.2
Alzheimer’s Disease (including proxy)	0.8	1.2	2.0	1.2	-0.9	-0.1	1.2	1.1	1.4	1.1
Body Mass Index (BMI) (2010)	0.8	1.0	2.1	0.7	0.6	0.8	1.4	1.1	0.7	1.4
LDL Cholesterol	0.8	1.2	2.5	1.6	-0.4	1.2	1.5	0.7	0.2	1.3
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.0	0.0	-0.2	-0.8	1.2	1.3	1.3	1.4
Qualifications: CSEs or equivalent	0.8	1.1	3.1	-0.0	0.3	0.9	-1.2	-1.1	-1.8	-0.9
Supplements: Glucosamine	0.8	1.0	1.8	-0.5	1.1	1.1	-1.0	-1.3	0.1	-1.3
Medication: Atenolol	0.8	1.0	2.6	-0.4	-1.6	-1.2	1.0	0.8	0.4	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	1.9	0.6	1.3	-1.2	-1.4	-0.5	-1.3	-0.8
Number of full brothers	0.8	1.0	1.9	0.7	-1.2	0.3	1.2	0.9	0.6	1.4
Number of children fathered	0.8	0.9	1.5	1.2	0.8	1.1	1.2	0.3	0.4	1.1
Medication: Seretide 50 evohaler	0.8	0.9	1.7	-1.2	-0.6	-1.3	0.6	0.9	-1.0	0.8
Had major operations	0.8	1.0	3.3	0.7	-0.4	-0.7	1.0	0.8	1.8	0.8
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.2	-1.4	-1.5	-0.7	-0.7	-0.6	-1.2	-0.5
Supplements: Vitamin C	0.8	1.0	4.3	-2.1	-0.9	-1.1	0.0	0.2	-0.5	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	3.4	-0.2	1.3	0.7	-1.6	-1.8	-0.1	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	3.3	0.9	-0.6	-1.8	0.4	0.8	0.6	0.5
Eye problems/disorders: Cataract	0.8	0.9	1.5	0.9	1.1	1.2	-0.9	-1.0	0.0	-0.9
Illnesses of father: None of the above (group 1)	0.8	1.0	2.3	1.0	0.4	0.2	-1.2	-1.5	-0.9	-1.1
Ever taken oral contraceptive pill	0.8	0.9	2.5	0.7	-0.5	1.4	-0.2	-1.1	1.6	-0.3
Supplements: Fish oil (including cod liver oil)	0.8	1.1	2.3	-0.4	1.5	1.0	-0.7	-1.2	1.2	-0.8
Bipolar Disorder or Schizophrenia	0.7	1.6	3.6	0.4	-1.1	-1.9	1.4	1.6	-0.1	1.4
Number of treatments/medications taken	0.7	1.3	2.1	1.4	-0.2	1.1	1.4	0.4	1.3	1.4
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.1	1.0	0.8	1.2	0.7	0.1	1.4	0.7
Ever had hysterectomy (womb removed)	0.7	0.8	2.7	-0.5	1.6	-0.1	-1.1	-0.7	-0.5	-1.0
Medication for hormone replacement therapy	0.7	0.7	2.2	-0.3	-1.5	-0.7	0.9	0.6	0.7	0.9
Sitting height	0.7	4.8	9.0	2.3	3.0	2.6	-1.5	-2.2	1.4	-1.8
Allergy	0.7	1.6	6.0	0.0	-2.4	-1.8	0.5	1.0	0.2	0.7
Depression (self-reported)	0.7	0.8	2.3	0.6	-0.1	-1.5	0.4	1.5	-0.6	0.6
Worry too long after embarrassment	0.7	1.1	2.9	1.0	1.7	1.2	-0.7	-1.0	-0.6	-0.7
Medication for pain relief, constipation, heartburn	0.7	1.2	3.7	0.7	-0.8	-1.9	0.8	1.5	0.1	0.8
Mood swings	0.7	1.3	2.5	0.1	1.5	1.6	-1.0	-1.3	-0.7	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.9	1.2	0.7	1.7	0.3	-0.3	1.7	0.1
Osteoporosis (self-reported)	0.7	0.9	2.6	1.5	1.6	0.8	-0.6	-0.7	-0.3	-0.2
Osteoarthritis (self-reported)	0.7	0.9	2.4	-0.1	-0.7	-0.9	1.1	0.8	1.5	1.0
Hearing aid user	0.7	0.8	1.7	-0.3	1.0	-0.2	-1.3	-1.1	-0.5	-1.2
Medication: Paracetamol	0.7	1.1	2.6	0.1	0.6	0.8	-1.1	-1.3	-1.6	-0.9
Alzheimer’s Disease (in mother)	0.6	0.7	2.5	0.5	0.4	1.1	0.1	-0.6	1.6	-0.2
Crohns Disease (2017)	0.6	1.3	1.8	-1.3	1.3	1.0	-1.0	-0.9	-1.0	-1.2
Ovarian Cancer	0.6	0.8	2.6	-0.6	0.1	0.2	-1.1	-0.7	-1.6	-0.7
Systolic Blood Pressure	0.6	3.2	9.5	-1.0	-0.7	-2.1	-2.1	-0.5	-3.1	-1.6
Allergy or Eczema	0.6	1.5	5.1	0.1	2.1	2.2	-0.2	-0.9	0.4	-0.2
Hearing difficulty/problems: Yes	0.6	1.0	3.0	-0.1	0.4	1.2	-0.4	-1.3	1.7	-0.5
Diabetes (mother)	0.6	0.8	2.0	0.4	-0.3	-1.2	0.7	1.2	1.4	0.6
Chronic bronchitis/emphysema (father)	0.6	0.7	3.4	-1.9	-1.1	0.2	0.2	0.1	0.2	0.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.8	-1.0	-0.2	-1.4	0.4	1.2	-0.8	0.4
Diabetes (self-reported)	0.6	1.0	1.8	-0.6	0.6	1.2	-0.7	-1.2	1.3	-0.9
Weight	0.6	3.0	8.0	1.0	2.8	2.6	-0.5	-1.5	1.3	-1.1
Hip circumference	0.6	2.5	5.2	0.1	2.3	2.3	-0.9	-1.9	0.9	-1.4
Number of live births	0.6	0.8	1.8	0.5	1.1	1.3	-0.2	-0.9	1.2	-0.5
Tense / ‘highly strung’	0.6	1.1	2.3	0.3	-1.4	-1.5	0.8	1.1	0.0	1.1
Hair/balding pattern: Pattern 4	0.6	1.5	2.9	-0.6	1.7	1.5	-1.0	-1.1	0.9	-1.3
Health satisfaction	0.6	0.8	2.3	0.1	1.4	1.5	-0.4	-1.0	-0.1	-0.7
Alcohol intake frequency.	0.6	1.4	3.4	1.8	0.8	1.3	0.9	0.2	1.7	0.5
Comparative height size at age 10	0.6	3.1	13.7	0.9	0.7	2.4	0.2	-1.1	3.7	-0.4
Suffer from ‘nerves’	0.6	1.0	3.3	1.8	1.1	1.3	0.3	0.0	0.4	0.6
Family relationship satisfaction	0.6	0.7	1.9	-0.2	-1.4	-0.7	0.9	1.0	0.3	1.0
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.5	-0.6	-0.4	-0.7	1.0	1.2	-0.2	1.1
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.6	1.3	-1.0	-0.6	0.8	0.4	0.9	0.7
Smoking status: Current	0.6	1.0	2.5	0.6	-1.3	-0.2	0.9	0.6	1.6	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.4	6.1	1.2	-0.0	2.5	0.8	-0.3	0.9	0.6
Alcohol drinker status: Never	0.6	0.7	1.5	-0.1	0.7	0.6	-1.2	-0.9	-0.3	-1.2
Age started oral contraceptive pill	0.6	0.8	2.9	0.6	0.6	0.7	0.9	0.4	1.7	0.6
Supplements: Calcium	0.6	0.7	2.2	-0.5	-0.8	0.2	1.5	0.5	0.3	1.2
Basal cell carcinoma (self-reported)	0.6	0.7	1.0	0.5	1.0	1.0	-0.4	-1.0	0.9	-0.6
Depression (Nagel 2018)	0.5	0.8	2.0	0.4	-0.3	-0.2	1.3	1.2	0.3	1.4
Major Depression (MDD)	0.5	0.6	3.0	0.2	-0.8	-1.7	-0.1	0.8	0.2	0.2
HbA1C	0.5	0.5	3.5	1.9	-0.1	-0.2	-0.2	-0.2	0.3	0.1
Rheumatoid Arthritis	0.5	0.6	1.5	1.2	0.9	0.6	-0.2	-0.3	1.2	-0.1
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.9	-1.7	0.0	0.0	-0.6	-0.3	-0.6	-0.7
Cardiovascular Disease	0.5	1.7	3.3	0.2	-1.2	-1.7	0.6	1.6	-1.8	1.0
Medication: Co-codamol	0.5	0.6	2.1	-0.3	0.9	0.6	0.7	0.2	1.4	0.7
Diabetes (father)	0.5	0.7	3.3	0.0	-0.4	0.4	0.8	0.5	1.8	0.4
Maternal smoking around birth	0.5	0.8	1.3	0.9	0.7	0.7	-1.0	-1.1	0.4	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.0	-0.4	-0.1	-0.2	1.3	1.1	-0.1	1.4
Multivitamins +/- minerals	0.5	0.6	2.2	-0.4	1.5	0.7	-0.6	-0.9	0.1	-0.6
Body mass index (BMI)	0.5	2.2	6.1	0.2	2.5	2.3	-0.7	-1.3	-0.4	-1.1
Waist circumference	0.5	1.7	5.8	0.7	2.1	2.4	0.1	-0.7	0.3	-0.3
Forced vital capacity (FVC)	0.5	1.9	5.1	2.3	-0.6	1.1	1.4	0.8	1.5	1.4
Neuroticism score	0.5	1.1	3.4	0.6	1.8	1.2	-1.0	-1.0	-0.5	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	3.3	-1.8	-0.5	0.7	-0.4	-0.7	0.2	-0.4
Medication: Lansoprazole	0.5	0.6	3.2	0.6	0.4	1.8	0.3	-0.7	0.2	0.1
Pulse wave reflection index	0.5	0.6	1.8	-0.8	-1.0	-1.3	0.1	0.8	-0.3	0.2
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.3	-1.1	1.0	-0.7	-1.0	-0.3	-1.0	-1.0
Medication: Amlodipine	0.5	0.7	1.4	0.5	-0.2	-0.9	0.7	1.0	-1.2	0.8
Shortness of breath walking on level ground	0.5	0.6	1.4	0.8	-1.0	-1.2	0.5	0.5	0.5	0.6
Migraine (self-reported)	0.5	0.6	1.6	0.6	-0.6	1.3	0.4	-0.1	-1.2	0.4
Number of full sisters	0.5	0.6	2.6	-0.5	-0.5	-1.6	0.4	0.8	0.0	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.3	-1.1	0.1	1.0	-0.3	-0.8	-0.7	-0.5
Diabetes diagnosed by doctor	0.5	0.9	2.4	-0.7	0.3	1.0	-0.6	-1.0	1.5	-0.8
Mineral and other dietary supplements	0.5	0.6	1.7	0.7	-0.6	-1.0	0.1	0.7	-1.3	0.3
Asthma (self-reported)	0.5	1.1	3.7	0.2	1.9	0.2	-1.1	-1.0	-0.5	-1.2
Medication: Bendroflumethiazide	0.5	0.8	1.6	1.2	0.0	-0.3	0.8	1.0	1.3	0.9
Medication: Lisinopril	0.5	0.7	3.7	0.1	-0.3	1.9	0.5	-0.2	0.7	0.3
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.3	0.7	-0.5	0.6	-0.4	-0.9	1.1	-0.7
Pain experienced in last month	0.5	0.8	4.3	-0.0	-2.1	-0.6	0.5	0.4	-0.1	0.5
Alcohol drinker status: Previous	0.5	0.6	1.7	-0.1	-0.2	-1.0	0.4	0.9	-1.3	0.6
Bipolar Disorder (2018)	0.4	0.6	2.0	-1.4	-0.4	0.1	-0.6	-0.5	-0.8	-0.8
Depressed Affect (Nagel 2018)	0.4	0.8	1.4	-0.3	1.2	1.1	-0.9	-1.0	-0.7	-0.7
Worry (Nagel 2018)	0.4	0.7	3.0	-0.2	0.7	0.1	-1.0	-0.4	-1.7	-0.7
Verbal and Numeric Reasoning (VNR)	0.4	0.9	4.4	1.1	0.2	0.6	0.3	-0.4	2.1	0.2
Breast Cancer	0.4	1.1	3.4	-1.9	-1.1	-0.5	0.1	-0.4	1.5	-0.2
Crohns Disease (2012)	0.4	0.7	2.7	-1.6	-0.3	-0.7	-0.5	0.0	-0.9	-0.6
BMI	0.4	2.3	7.2	-0.2	2.7	2.3	-0.7	-1.3	-0.4	-1.1
Respiratory disease	0.4	0.9	2.6	0.3	1.6	0.6	-1.0	-1.0	-0.8	-0.9
Townsend deprivation index at recruitment	0.4	0.6	1.5	-0.0	0.9	0.3	0.9	0.6	1.2	0.7
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	2.3	-0.4	0.0	-1.5	-0.1	0.9	-0.0	-0.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.7	1.1	0.2	-1.3	-0.2	0.3	-0.2	-0.1
High blood pressure (mother)	0.4	0.5	1.2	1.1	0.5	0.0	-1.0	-0.6	-0.0	-0.9
Number of incorrect matches in round	0.4	0.7	1.9	-1.4	-0.7	-1.3	0.5	0.5	0.4	0.3
Fluid intelligence score	0.4	0.8	1.4	0.9	0.3	-0.7	0.9	1.1	1.2	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.9	-0.4	0.7	-1.7	-0.5	0.4	-1.0	-0.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.5	1.5	-0.3	1.6	1.2	0.6	1.1	1.1
Asthma	0.4	0.8	2.5	0.0	1.6	0.0	-1.0	-0.8	-0.6	-1.0
Medication: Cholesterol lowering	0.4	0.7	2.1	0.4	-0.2	1.4	-0.5	-1.4	0.0	-0.5
Arm fat mass (right)	0.4	1.5	4.9	0.4	2.2	2.0	-0.3	-0.9	0.4	-0.7
Peak expiratory flow (PEF)	0.4	1.0	2.9	0.1	1.0	1.7	-0.8	-1.0	-0.7	-0.9
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.7	1.3	0.1	0.3	-0.6	-0.8	-0.5	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.5	-0.5	-0.3	-0.6	0.3	1.1	-1.2	0.4
Heart disease (mother)	0.4	0.5	0.8	0.9	-0.9	-0.5	0.7	0.1	0.6	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	2.7	-1.6	0.1	-0.2	0.1	0.3	-0.6	-0.0
Arm fat mass (left)	0.4	1.6	5.3	0.4	2.3	2.0	-0.3	-0.9	0.4	-0.7
Wears glasses or contact lenses	0.4	0.4	0.6	0.5	0.4	0.6	-0.7	-0.8	-0.6	-0.7
Commuting to job workplace: Cycle	0.4	0.5	1.0	1.0	0.7	0.8	0.6	0.7	0.6	0.5
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.0	-0.3	1.2	1.0	-1.1	-1.4	0.1	-1.2
Neuroticism (Nagel 2018)	0.3	0.6	2.0	0.5	1.4	0.9	-0.6	-0.6	-0.7	-0.3
Irritable Bowel Disease (IBD)	0.3	0.8	2.6	-1.6	-0.1	-0.0	0.1	0.5	-1.6	-0.1
Reaction Time	0.3	0.5	1.8	-0.2	-1.1	-0.3	-0.3	-0.6	-1.3	-0.4
Prostate Cancer	0.3	0.4	0.7	0.3	0.6	0.8	-0.7	-0.3	-0.5	-0.7
Blood White Count	0.3	1.9	4.3	2.0	0.3	2.1	0.6	0.3	1.9	0.7
Lung FEV1/FVC ratio	0.3	1.6	5.9	-2.4	0.1	1.9	-0.1	-1.1	0.3	-0.3
Neuroticism	0.3	0.7	2.9	1.7	1.0	0.9	-0.3	-0.5	-0.3	0.1
Tanning	0.3	3.6	7.0	2.6	-1.5	0.6	2.1	0.9	2.3	2.2
Average weekly spirits intake	0.3	0.4	1.8	0.4	1.4	-0.1	-0.2	0.0	0.6	-0.4
Relative age of first facial hair	0.3	0.6	1.7	1.0	0.9	1.3	-0.4	-0.8	-0.0	-0.2
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.8	-0.8	1.3	0.2	-0.3	-0.3	0.1	-0.6
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.8	0.8	0.3	0.6	0.5	-0.1	0.9	0.3
Medication: Metformin	0.3	0.4	1.5	-0.9	0.1	-0.0	-0.1	-0.3	1.2	-0.3
Age when periods started (menarche)	0.3	0.6	1.3	0.7	-0.6	0.5	1.0	0.9	-0.2	1.1
High blood pressure	0.3	0.8	1.9	0.1	-0.9	-1.2	0.7	1.4	-0.2	0.8
Hair/balding pattern: Pattern 2	0.3	0.3	0.8	-0.3	0.9	-0.4	-0.5	-0.2	-0.9	-0.4
Pain all over the body in last month	0.3	0.3	0.6	-0.7	0.1	-0.1	0.7	0.6	0.8	0.5
Medication: Simvastatin	0.3	0.5	2.0	0.1	0.1	1.4	-0.0	-1.0	0.4	-0.3
Prospective memory result	0.3	0.3	2.0	1.4	-0.3	-0.2	0.0	0.2	-0.1	0.3
Illnesses of mother	0.3	0.4	1.0	-1.0	0.7	0.4	-0.6	-0.2	-0.7	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.9	0.8	-0.2	1.7	1.0	0.3	1.1	0.7
Standing height	0.3	2.5	11.9	1.7	1.1	0.9	-0.1	-0.8	3.5	-0.6
Medication: Ventolin 100micrograms inhaler	0.3	0.3	1.3	-0.4	1.2	0.8	-0.2	-0.3	-0.2	-0.3
Forced vital capacity (FVC), Best measure	0.3	1.1	2.2	1.2	-0.7	1.1	1.1	0.5	1.5	1.0
Emphysema/chronic bronchitis	0.3	0.3	0.9	0.4	-0.1	-0.0	-0.7	-1.0	-0.1	-0.7
Mean time to correctly identify matches	0.3	0.5	1.8	-0.5	-1.4	-0.5	0.0	-0.2	-1.0	-0.1
Average weekly red wine intake	0.3	0.5	1.1	-1.1	-0.8	-0.9	0.2	0.5	0.7	0.2
Loneliness, isolation	0.3	0.5	1.0	-0.3	1.0	0.6	0.6	0.3	0.9	0.7
Breast cancer (self-reported)	0.3	0.3	1.4	1.2	-0.3	0.0	0.3	0.5	0.0	0.6
Medication: Gliclazide	0.3	0.3	1.5	-1.2	0.1	-0.6	0.1	0.4	0.2	0.0
Miserableness	0.3	0.4	1.3	-1.1	0.8	-0.3	-0.8	-0.4	0.2	-0.6
Mother’s age at death	0.3	0.3	1.2	0.4	1.1	0.9	-0.2	-0.4	0.0	-0.2
High cholesterol (Self-reported)	0.3	0.5	2.4	0.5	0.6	1.5	-0.0	-0.7	-0.4	0.0
Unable to work because of sickness or disability	0.3	0.4	2.6	-1.6	-0.2	-0.2	0.2	0.1	0.4	0.1
Myopia	0.3	0.4	0.9	-0.4	0.4	0.2	-0.8	-0.8	-0.8	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.7	0.1	0.6	1.3	-0.1	-0.5	-0.4	-0.3
Pack years of smoking	0.3	0.4	1.3	1.1	-0.2	0.5	0.8	0.5	0.3	0.7
Age at First Birth	0.2	0.4	0.9	-0.3	-0.1	0.6	0.9	0.5	-0.1	0.9
Height	0.2	4.8	26.9	2.0	-0.4	-0.4	1.2	0.6	5.2	0.6
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.4	-0.2	-0.0	0.5	-0.3	-0.7	1.2	-0.5
Hand grip strength (left)	0.2	0.5	1.2	0.2	0.4	0.4	-0.9	-0.9	0.7	-1.1
Vitamin and mineral supplements	0.2	0.3	1.0	1.0	-0.1	-0.4	-0.1	0.7	-0.5	-0.0
Pack years adult smoking proportion	0.2	0.2	0.8	0.9	-0.1	0.5	0.6	0.2	0.2	0.5
Hand grip strength (right)	0.2	0.4	1.0	0.9	0.3	0.6	-0.5	-0.5	1.0	-0.5
Average weekly fortified wine intake	0.2	0.3	1.2	0.5	-0.3	0.3	0.5	-0.1	1.1	0.3
Relative age voice broke	0.2	0.3	1.3	1.1	0.4	0.4	0.3	0.1	0.5	0.5
Stomach or abdominal pain in last month	0.2	0.2	0.5	-0.7	0.5	-0.4	0.2	0.6	0.1	0.3
Trunk fat mass	0.2	0.7	2.5	0.0	1.6	1.5	0.2	-0.2	0.5	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.8	0.5	-0.9	-0.9	0.1	0.4	0.2	0.5
Had menopause	0.2	0.3	1.4	-0.4	-0.6	-1.2	0.0	0.2	-0.1	-0.1
Financial difficulties in last 2 years	0.2	0.3	1.0	0.4	1.0	-0.6	0.5	0.5	-0.1	0.6
Father’s age at death	0.2	0.3	1.1	0.4	0.3	1.1	0.3	-0.2	0.7	0.0
Glaucoma (self-reported)	0.2	0.3	0.5	0.7	-0.6	-0.2	0.5	0.3	0.4	0.7
Birth weight	0.2	0.5	2.8	-1.7	-0.1	-0.8	0.2	0.2	0.1	-0.1
High blood pressure (siblings)	0.2	0.3	0.6	0.7	0.5	-0.4	0.3	0.8	0.1	0.2
Exposure to tobacco smoke outside home	0.2	0.3	1.5	-1.2	0.1	-0.4	0.3	0.2	0.5	0.2
Wheeze or whistling in the chest in last year	0.2	0.3	2.0	0.5	1.4	-0.2	-0.1	-0.1	0.3	0.0
Qualifications: College or University degree	0.2	0.6	2.4	-0.1	-0.7	-1.5	0.4	0.7	-0.3	0.5
Medication: Omeprazole	0.2	0.2	0.7	-0.0	0.2	0.9	0.0	-0.3	-0.7	-0.1
Whole body fat mass	0.2	0.9	3.1	0.3	1.8	1.7	0.2	-0.3	0.5	-0.2
Chest pain or discomfort	0.2	0.3	0.9	0.4	0.6	0.6	-0.3	-0.9	0.5	-0.4
Hypertension (Self-reported)	0.2	0.5	1.1	0.5	-0.7	-0.8	0.6	1.1	-0.1	0.7
Long-standing illness, disability or infirmity	0.2	0.3	0.9	-0.2	-0.2	0.0	0.7	0.7	0.9	0.6
Friendships satisfaction	0.2	0.2	0.6	-0.7	-0.3	-0.7	0.2	0.3	-0.1	0.2
Qualifications: nursing, teaching	0.2	0.3	0.6	-0.6	-0.8	-0.0	0.6	0.6	0.0	0.5
Commuting to job workplace: Walk	0.2	0.3	0.7	0.4	0.4	-0.6	0.2	0.6	0.8	0.2
Number of self-reported non-cancer illnesses	0.2	0.3	1.0	0.2	1.0	0.2	-0.6	-0.5	-0.5	-0.5
Eye problems/disorders: Glaucoma	0.2	0.3	1.1	0.0	-0.1	-1.1	0.3	0.5	0.0	0.6
Average weekly beer plus cider intake	0.2	0.2	0.6	-0.1	0.3	0.4	-0.6	-0.3	-0.8	-0.4
Fractured/broken bones in last 5 years	0.2	0.3	0.8	-0.1	-0.6	-0.9	0.2	0.7	-0.6	0.3
Heart disease (siblings)	0.2	0.3	1.0	0.0	0.2	0.4	0.7	-0.1	1.0	0.5
Leg fat mass (left)	0.2	0.8	3.2	0.4	1.8	1.4	0.3	-0.2	0.3	-0.1
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.5	0.2	-0.3	0.1	0.6	0.1	0.7	0.7
Waist Hip Ratio (WHR)	0.1	0.6	1.5	1.2	0.3	0.4	0.4	0.8	-1.1	0.7
Hair Pigment	0.1	1.8	3.9	-1.0	1.4	0.4	-1.6	-2.0	-0.1	-1.8
Trunk fat percentage	0.1	0.3	0.8	-0.6	0.8	0.9	0.4	0.2	-0.4	0.1
Serious illness, injury or assault to yourself	0.1	0.1	0.5	-0.7	-0.3	0.3	0.3	0.1	-0.1	0.3
Alcohol usually taken with meals	0.1	0.2	1.5	0.2	-0.2	-0.1	0.2	-0.1	1.2	0.1
Nervous feelings	0.1	0.3	1.0	0.2	0.8	1.0	0.2	0.0	-0.1	0.3
Qualifications: None of the above	0.1	0.1	0.4	0.3	-0.2	0.6	-0.1	-0.5	0.3	-0.2
Arm fat percentage (right)	0.1	0.4	1.3	-0.6	1.1	0.8	-0.0	-0.2	-0.5	-0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.7	-0.5	0.2	-0.8	0.2	0.1	0.7	0.3
Exposure to tobacco smoke at home	0.1	0.2	0.5	-0.1	0.7	0.2	0.5	0.4	0.3	0.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.4	-0.2	0.6	0.3	0.1	0.5	-0.2	0.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.9	0.5	0.9	-0.0	-0.2	0.3	-0.5	0.1
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.4	0.4	0.0	0.1	0.6	0.3	-0.1	0.6
Body fat percentage	0.1	0.3	0.7	-0.4	0.8	0.8	0.5	0.3	-0.4	0.2
Leg fat percentage (right)	0.1	0.4	0.7	-0.6	0.1	0.1	0.8	0.8	-0.8	0.6
Eye problems/disorders: None of the above	0.1	0.1	0.9	-1.0	-0.2	0.2	-0.0	-0.1	0.1	-0.0
Leg fat mass (right)	0.1	0.6	2.3	0.1	1.5	1.2	0.3	-0.1	0.2	-0.1
Overall health rating	0.1	0.1	0.3	-0.5	0.4	0.4	0.2	-0.3	-0.1	-0.0
Arm fat percentage (left)	0.1	0.4	1.7	-0.2	1.3	0.9	0.0	-0.2	-0.6	-0.2
Medication for cholesterol	0.1	0.1	0.3	-0.2	0.6	0.1	-0.4	-0.3	0.1	-0.4
Guilty feelings	0.1	0.1	0.4	0.6	-0.1	-0.1	0.3	0.1	0.3	0.6
Financial situation satisfaction	0.1	0.1	0.2	0.2	0.4	0.2	0.2	0.2	-0.5	0.0
Medication: Blood pressure	0.1	0.2	0.5	0.7	0.3	-0.3	0.1	0.6	0.5	0.3
Leg fat percentage (left)	0.1	0.3	0.5	-0.1	0.5	0.5	0.7	0.7	-0.7	0.5
Irritability	0.1	0.2	1.2	1.1	-0.1	-0.2	-0.2	0.2	-0.1	0.3
Noisy workplace	0.0	0.1	0.1	0.2	-0.4	0.1	0.3	0.0	0.2	0.3

Hub : Genes

C4orf36

Models

Trait associations