[Hub]/) : Traits : Respiratory disease : ← →

chr6:34,528,785-35,987,507

Best TWAS P=4.93e-10 · Best GWAS P=2.68e-10 conditioned to 0.0666

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Nerve Tibial DEF6 0.15 0.00 lasso 8 0.00 1.6e-01 6.3 -5.4 7.8e-08 -0.74 0.03 0.84 FALSE
2 GTEx Testis ZNF76 0.15 0.14 enet 8 0.12 4.4e-06 5.5 -5.5 3.6e-08 -0.67 0.61 0.36 FALSE
3 NTR Blood DEF6 0.03 0.02 bslmm 420 0.02 7.2e-07 6.3 -5.4 8.7e-08 -0.73 0.02 0.98 FALSE
4 NTR Blood ZNF76 0.01 0.00 blup 424 0.00 3.8e-02 6.3 -5.6 2.2e-08 -0.80 0.02 0.90 FALSE
5 ROSMAP Brain Pre-frontal Cortex DEF6 0.04 0.02 bslmm 421 0.02 1.8e-03 3.5 -6.0 2.3e-09 -0.82 0.04 0.95 FALSE
6 ROSMAP Brain Pre-frontal Cortex ZNF76 0.04 0.00 blup 424 0.02 2.1e-03 6.3 -5.3 1.0e-07 -0.81 0.02 0.96 FALSE
7 YFS Blood ZNF76 0.05 0.08 lasso 4 0.07 6.7e-23 6.2 -6.2 4.9e-10 -0.87 0.03 0.97 TRUE
8 The Cancer Genome Atlas Brain Lower Grade Glioma DEF6 0.04 0.01 blup 50 0.03 6.2e-04 6.2 -5.4 7.1e-08 -0.77 0.01 0.95 FALSE
9 The Cancer Genome Atlas Liver Hepatocellular Carcinoma ZNF76 0.08 0.05 lasso 10 0.07 4.9e-04 5.7 5.4 7.4e-08 0.75 0.04 0.54 FALSE
10 The Cancer Genome Atlas Prostate Adenocarcinoma ZNF76 0.03 0.02 lasso 3 0.02 3.5e-03 4.6 -5.7 1.2e-08 -0.72 0.05 0.85 FALSE
11 The Cancer Genome Atlas Thyroid Carcinoma SCUBE3 0.03 0.01 blup 62 0.03 8.9e-04 5.7 -5.9 4.3e-09 -0.82 0.03 0.79 FALSE