Hub : Genes

ZNF76

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Testis 0.1460 0.0470 6.1e-05 0.137 NA 0.123 NA 0.122 1.2e-06 NA 4.4e-06 NA 4.7e-06
2 METSIM Adipose 0.1145 0.0374 1.8e-09 0.069 0.064 0.052 0.062 0.064 1.5e-10 6.3e-10 2.7e-08 1.2e-09 6.7e-10
3 NTR Blood 0.0099 0.0051 4.9e-03 0.003 0.003 0.000 0.002 0.001 4.2e-02 3.8e-02 3.5e-01 4.9e-02 1.0e-01
4 ROSMAP Brain Pre-frontal Cortex 0.0360 0.0164 1.2e-03 0.004 0.018 0.003 0.015 0.007 1.0e-01 2.1e-03 1.1e-01 4.3e-03 3.4e-02
5 YFS Blood 0.0473 0.0121 0.0e+00 0.077 0.060 0.071 0.071 0.073 6.3e-24 4.6e-19 3.6e-22 3.6e-22 6.7e-23
6 TCGA Liver Hepatocellular Carcinoma 0.0760 0.0460 2.3e-03 0.053 0.046 0.054 NA 0.066 1.6e-03 3.1e-03 1.5e-03 NA 4.9e-04
7 TCGA Prostate Adenocarcinoma 0.0300 0.0212 2.2e-03 0.022 0.012 0.016 NA 0.020 2.0e-03 1.7e-02 6.9e-03 NA 3.5e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.1 0.1 0.6 0.4 -0.8 -0.4 -0.1 -0.3 -0.0 0.1
Bipolar Disorder or Schizophrenia 0.3 0.7 1.5 0.7 0.0 1.1 1.2 0.9 -0.8 0.5
Depressed Affect (Nagel 2018) 0.1 0.3 0.9 -0.5 -0.5 -0.9 0.2 -0.2 0.7 -0.0
Depression (Nagel 2018) 0.2 0.3 0.5 -0.7 0.3 0.7 0.6 -0.1 0.4 -0.4
Intelligence (Savage-Jansen 2018) 0.3 0.9 2.0 1.1 -0.6 1.1 0.5 1.1 -0.1 1.4
Neuroticism (Nagel 2018) 0.4 1.0 2.8 -1.4 -0.2 -0.6 1.0 -0.2 1.7 -0.9
Schizophrenia (2018) 0.7 1.4 3.2 0.6 0.7 1.8 1.7 1.3 -0.9 0.5
Schizophrenia vs Biploar Disorder 0.3 0.4 1.7 0.3 0.4 0.5 1.3 0.7 -0.1 0.4
Worry (Nagel 2018) 0.9 1.8 4.3 -2.1 0.1 -0.7 0.4 -0.7 2.0 -1.8
Alzheimer’s Disease (in mother) 2.3 2.7 5.1 1.2 1.0 1.9 2.3 2.1 -0.7 1.6
Alzheimer’s Disease (in father) 0.8 0.8 2.0 0.6 0.9 1.4 0.9 1.0 -0.3 0.8
Alzheimer’s Disease (including proxy) 2.2 3.1 5.2 1.6 1.4 2.3 1.9 2.0 -0.7 2.0
Crohns Disease (2017) 0.3 0.6 1.8 0.3 1.3 0.8 1.3 0.6 -0.2 0.2
Irritable Bowel Disease (IBD) 0.3 0.8 2.6 -0.9 0.9 0.5 1.6 0.6 0.7 -0.4
Ulcerative Colitis (UC) 1.0 1.9 5.0 -2.2 -0.3 -0.7 0.9 -0.4 2.0 -1.7
Major Depression (MDD) 0.5 0.6 2.0 -0.6 0.9 -0.5 -1.4 -0.6 -0.4 -0.3
Reaction Time 0.4 0.9 3.1 -0.7 -0.1 -1.8 -1.3 -0.7 0.1 -0.4
Verbal and Numeric Reasoning (VNR) 1.2 2.8 5.5 1.6 0.4 2.3 1.3 2.1 -0.9 2.0
Breast Cancer 0.3 0.7 1.5 0.2 0.1 0.9 1.0 1.2 -1.0 0.8
Ovarian Cancer 0.1 0.1 0.4 -0.2 -0.5 0.1 -0.2 0.0 0.6 -0.5
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.3 0.4 1.6 -1.2 0.9 -0.1 -0.1 0.1 0.3 -0.7
Bipolar Disorder (2011) 0.2 0.2 1.0 -0.3 -0.3 0.1 0.2 0.2 -1.0 -0.3
Body Mass Index (BMI) (2010) 0.3 0.4 1.2 1.1 0.0 -0.5 0.3 -0.3 -0.8 0.6
Coronary Artery Disease (CAD) 0.6 0.7 3.0 -0.5 -1.1 -1.7 -0.0 -0.3 0.3 0.0
Crohns Disease (2012) 0.7 1.1 2.1 0.6 1.5 1.4 1.1 1.1 -0.6 0.7
Mean Putamen Volume 2.8 3.2 5.2 1.8 2.1 0.9 -0.0 2.0 -2.3 2.2
Fasting Glucose 0.6 0.7 1.6 1.2 -0.7 0.9 0.6 -0.2 0.5 1.2
HbA1C 1.6 1.8 3.5 0.4 0.9 0.7 1.8 1.8 -1.9 0.9
HDL Cholesterol 2.6 4.3 15.9 -1.1 -0.8 -0.9 -4.0 -2.0 2.1 -1.8
LDL Cholesterol 2.6 4.1 8.3 -0.9 -1.5 -2.5 -2.9 -2.4 1.7 -1.4
Lupus 7.9 11.9 21.9 -2.4 -2.6 -4.7 -3.5 -4.2 3.0 -3.2
Neuroticism (2016) 0.3 0.5 1.1 -0.9 0.3 -0.5 -1.1 -0.5 0.5 -0.6
Primary Biliary Cirrhosis 2.6 3.7 6.8 -1.1 -2.4 -2.6 -2.2 -1.9 1.5 -1.3
Rheumatoid Arthritis 0.7 0.9 2.1 1.4 0.7 0.7 1.3 0.6 -0.4 1.1
Schizophrenia (2014) 0.4 0.8 1.9 0.7 0.3 1.2 1.4 0.9 -0.9 0.5
Triglycerides 0.9 1.4 6.7 0.1 -2.6 -0.5 -0.6 -1.3 1.0 -0.4
Type 2 Diabetes (T2D) (2012) 3.0 3.4 8.0 -2.8 -1.3 -0.8 -0.7 -1.9 1.9 -2.5
Ulcerative Colitis 1.6 2.3 5.5 -2.1 -1.5 -0.6 -0.0 -1.0 2.3 -1.7
Blood Eosinophil Count 1.8 14.2 40.9 -6.4 -2.1 -5.1 -0.4 -2.0 1.7 -4.6
Blood Platelet Count 0.8 9.4 25.6 -3.3 5.1 2.7 3.4 2.6 -1.4 -1.2
Blood Red Count 0.3 3.1 8.6 1.9 2.9 1.6 0.7 1.1 -0.7 2.1
Blood White Count 9.5 70.6 92.2 6.0 9.6 8.0 8.9 9.4 -8.6 7.7
Heel T-Score 2.8 22.1 49.3 2.7 4.0 6.2 7.0 4.8 -2.8 3.6
BMI 0.5 2.8 10.6 1.0 -1.8 -3.2 0.8 -0.7 -1.0 1.6
Height 8.5 164.2 246.5 13.6 5.0 15.7 13.2 12.9 -14.0 12.5
Waist Hip Ratio (WHR) 0.5 2.5 4.9 -1.7 2.0 2.2 1.6 0.5 -1.4 -0.7
Systolic Blood Pressure 2.0 10.0 23.1 -4.8 -0.2 -3.6 -1.9 -2.6 2.6 -4.1
Smoking Status 0.4 1.0 1.7 -1.2 -1.3 -1.3 -1.0 -0.7 -0.4 -0.5
Allergy or Eczema 4.3 11.4 18.0 -3.3 -2.9 -3.2 -1.5 -3.5 4.2 -4.1
Cardiovascular Disease 1.5 5.1 17.6 -2.4 -2.1 -4.2 -1.0 -1.8 1.2 -1.6
Hypothyroidism (self reported) 3.7 8.5 13.7 3.1 2.0 0.2 3.6 3.2 -3.0 3.7
Respiratory disease 13.5 30.0 38.7 -5.5 -4.5 -5.6 -5.3 -6.2 5.4 -5.7
Type 2 Diabetes (T2D) (2018) 1.4 2.6 6.5 0.7 1.2 1.9 2.5 1.5 -1.5 1.3
Lung FEV1/FVC ratio 12.2 61.7 90.2 7.5 5.2 8.7 9.5 8.3 -7.1 7.9
Lung FVC 2.6 13.1 31.8 3.9 3.5 5.6 1.9 3.6 -1.8 3.5
Neuroticism 0.4 0.9 2.0 -1.4 -0.3 -1.0 0.3 -0.5 1.4 -1.0
Chronotype (morning person) 1.6 3.6 6.8 1.9 2.6 1.1 0.5 1.9 -2.4 2.0
Hair Pigment 0.8 22.9 48.3 3.6 3.0 4.9 7.0 5.4 -3.6 4.8
Tanning 0.1 0.7 2.1 -0.5 -1.4 -0.6 -0.5 -0.8 0.7 -0.8
Hand grip strength (left) 4.4 11.5 22.3 3.3 1.5 4.7 4.0 3.7 -2.7 3.0
Number of treatments/medications taken 1.8 3.2 8.8 -2.1 -1.7 -3.0 -0.7 -1.7 1.0 -1.5
Average weekly spirits intake 1.0 1.2 2.8 -1.3 -1.5 -1.7 -0.1 -1.0 0.6 -0.8
Sensitivity / hurt feelings 2.4 4.1 8.6 1.3 1.6 1.9 2.9 2.6 -1.0 2.1
Frequency of depressed mood in last 2 weeks 0.4 0.5 1.2 1.1 0.4 0.8 0.8 0.4 0.3 1.0
Hearing difficulty/problems: Yes 0.8 1.2 2.5 0.5 0.7 0.5 1.3 1.6 -1.6 0.9
Relative age of first facial hair 0.2 0.3 0.8 -0.0 -0.1 0.8 0.8 0.9 -0.6 0.0
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 2.1 -0.0 -1.5 -1.1 0.3 -0.6 -0.1 -0.3
Ever used hormone-replacement therapy (HRT) 2.3 3.0 4.9 -2.2 -1.8 -0.8 -0.7 -2.0 1.8 -2.0
Ever had hysterectomy (womb removed) 2.7 3.0 6.2 -1.8 -2.5 -0.9 -1.2 -2.0 1.4 -1.9
Systolic blood pressure, automated reading 3.7 10.6 20.5 -4.5 -1.1 -3.6 -2.7 -3.1 2.8 -3.9
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 1.5 0.6 1.2 1.0 0.3 0.6 -1.0 0.6
Angina 0.7 0.9 1.3 -0.9 -1.1 -1.1 0.7 -1.1 0.7 -0.8
Medication for hormone replacement therapy 0.5 0.5 2.2 0.0 0.4 1.5 0.7 0.6 -0.6 0.3
Vitamin and mineral supplements 1.0 1.3 3.1 1.6 0.8 0.5 0.5 1.0 -1.2 1.8
Supplements: Zinc 0.2 0.2 0.5 0.5 -0.6 0.7 0.1 0.3 -0.1 0.1
Medication: Co-codamol 0.6 0.7 2.0 0.1 1.3 -0.3 -1.4 -0.3 -1.1 0.3
Medication: Metformin 1.5 2.1 3.4 1.7 0.5 1.6 1.8 1.3 -1.0 1.7
Diabetes (father) 0.8 1.0 2.2 -0.9 -0.3 -0.7 -1.5 -1.1 0.8 -1.2
Diabetes (mother) 4.4 5.7 7.9 2.8 2.0 2.6 2.3 2.4 -2.1 2.3
Severe depression (siblings) 2.9 3.3 4.4 1.7 2.1 1.6 1.8 1.9 -1.6 2.0
Pack years adult smoking proportion 0.2 0.3 0.8 0.8 -0.1 -0.8 0.0 -0.1 -0.1 0.9
Impedance of leg (right) 0.2 0.8 1.3 -0.9 1.0 1.0 0.9 1.2 -0.5 -0.7
Leg fat-free mass (left) 4.5 24.0 40.7 6.4 0.8 4.4 4.8 4.2 -5.5 6.0
Trunk fat percentage 0.8 3.1 13.0 -0.2 -2.2 -3.6 0.0 -0.9 -1.7 -0.0
Hand grip strength (right) 3.7 10.1 18.8 2.9 1.0 4.3 4.0 3.5 -2.5 2.8
Townsend deprivation index at recruitment 0.7 0.9 3.5 1.9 -0.7 -0.3 0.4 0.1 -0.6 1.5
Current tobacco smoking 0.3 0.5 1.2 0.7 -1.0 -0.5 0.4 0.5 -0.2 1.1
Average weekly fortified wine intake 2.3 2.7 5.3 -1.0 -2.3 -1.3 -1.6 -1.6 1.9 -1.5
Maternal smoking around birth 0.1 0.2 0.5 0.4 -0.7 0.2 0.1 -0.4 0.1 0.7
Fed-up feelings 0.1 0.3 1.1 0.2 -0.4 -1.0 0.2 0.1 0.5 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 1.0 -1.0 -0.0 0.3 0.7 0.1 0.2 -0.6
Relative age voice broke 0.2 0.3 1.0 0.1 0.4 1.0 0.6 0.7 -0.6 0.1
Taking other prescription medications 0.4 0.6 1.8 -0.7 0.5 -1.0 1.3 0.2 -0.6 0.2
Age when periods started (menarche) 0.1 0.4 1.3 -1.1 -0.4 -0.6 0.1 -0.0 0.4 -0.7
Bilateral oophorectomy (both ovaries removed) 0.6 0.6 2.8 -0.3 0.0 1.0 1.7 0.7 0.3 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 3.6 8.2 17.7 2.2 1.9 2.4 4.2 3.6 -1.7 3.0
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.3 0.3 0.4 0.3 0.6 -0.2 -0.2 -0.2
Qualifications: CSEs or equivalent 0.7 1.0 3.3 0.4 -0.5 -1.5 -1.8 -0.8 0.4 0.4
Serious illness, injury or assault to yourself 0.2 0.2 0.5 -0.7 0.1 -0.2 0.6 0.4 -0.6 0.0
High blood pressure 0.7 2.0 5.2 -1.6 -1.2 -2.3 -0.0 -1.2 1.6 -1.0
Hayfever, allergic rhinitis or eczema 2.3 5.0 7.7 -2.5 -1.2 -2.1 -1.4 -2.6 2.5 -2.8
Multivitamins +/- minerals 0.2 0.2 0.4 -0.4 -0.0 0.6 -0.1 -0.5 0.6 -0.6
Stomach or abdominal pain in last month 0.8 1.0 2.3 1.3 0.7 0.4 0.6 0.6 -1.5 1.1
Supplements: Glucosamine 2.0 2.6 5.6 -1.9 -1.6 -0.4 -1.4 -1.7 1.3 -2.4
Diverticular disease/diverticulitis (self-reported) 1.3 1.5 5.2 1.1 1.0 2.3 0.7 1.0 -0.9 1.0
Medication: Atenolol 0.7 0.9 3.2 -0.3 -1.2 -1.8 -0.4 -0.8 0.9 -0.2
Medication: Levothyroxine sodium 4.2 7.1 13.8 3.0 1.8 -0.4 2.7 3.1 -2.5 3.7
Sitting height 2.8 19.7 30.4 5.2 0.9 4.9 4.2 3.9 -5.5 4.8
Chronic bronchitis/emphysema (father) 0.2 0.2 0.7 -0.5 -0.4 -0.3 0.8 0.1 0.6 0.0
High blood pressure (mother) 1.0 1.4 2.8 1.7 1.5 0.4 -0.6 1.0 -1.1 1.5
Body mass index (BMI) 0.6 2.5 10.7 0.7 -2.0 -3.3 -0.0 -1.2 -0.4 0.9
Impedance of leg (left) 0.2 0.8 3.1 -1.8 0.3 0.3 0.1 0.3 0.0 -1.5
Leg predicted mass (left) 4.7 24.7 42.0 6.5 0.9 4.4 4.9 4.3 -5.6 6.1
Trunk fat mass 0.9 3.9 11.8 1.9 -1.4 -1.1 1.9 0.8 -3.4 2.1
Waist circumference 1.0 3.7 9.2 2.3 -0.4 -0.1 2.1 0.8 -3.0 2.5
Number of incorrect matches in round 1.2 1.9 4.7 1.2 1.4 0.9 2.2 1.5 -1.2 1.1
Past tobacco smoking 0.5 1.0 4.1 -0.0 0.2 1.1 2.0 0.7 0.9 -0.2
Alcohol usually taken with meals 0.1 0.1 0.3 -0.3 0.5 -0.2 0.2 0.0 0.0 -0.4
Nervous feelings 0.8 1.5 2.6 -1.4 0.0 -1.4 -0.9 -1.0 1.6 -1.5
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 0.9 -0.6 0.0 -0.5 -0.6 -0.9 0.9 -0.9
Hearing difficulty/problems with background noise 0.0 0.1 0.2 0.1 0.0 -0.5 -0.1 0.5 -0.0 0.0
Hair/balding pattern: Pattern 2 2.2 2.8 5.3 -1.2 -2.3 -1.3 -1.5 -1.6 2.1 -1.3
Had menopause 1.2 1.5 2.4 -1.3 -0.8 -1.2 -1.2 -1.4 1.0 -1.5
Had other major operations 0.2 0.2 0.6 0.2 0.6 0.3 0.1 0.4 -0.8 0.5
Forced vital capacity (FVC) 10.4 39.9 85.6 6.5 4.2 9.2 5.5 6.2 -5.8 5.8
Heel bone mineral density (BMD) T-score, automated (right) 4.8 11.1 22.4 2.7 2.5 3.2 4.7 4.0 -2.0 3.4
Ever unenthusiastic/disinterested for a whole week 3.1 3.7 10.8 1.2 3.3 2.2 1.4 1.6 -1.9 1.0
Qualifications: None of the above 1.1 2.4 4.0 -1.4 -1.5 -2.0 -1.4 -1.8 0.9 -1.7
Financial difficulties in last 2 years 0.9 1.3 2.8 1.7 0.6 0.2 1.1 1.0 -0.9 1.6
Mouth/teeth dental problems 0.3 0.5 1.0 0.9 0.4 0.5 0.7 0.7 -1.0 0.6
Heart attack 1.5 1.9 5.1 -0.9 -2.3 -1.9 0.3 -1.3 0.9 -0.9
Allergy 6.0 13.9 18.3 3.9 2.8 3.8 2.9 4.3 -4.0 4.2
Pain all over the body in last month 0.6 0.7 2.4 0.3 -0.7 0.7 1.6 0.6 0.3 0.8
Diabetes (self-reported) 0.4 0.7 1.2 0.2 0.8 0.8 1.1 0.8 -0.9 0.8
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 2.4 0.8 0.6 0.8 1.5 0.8 -0.8 0.9
Medication: Ramipril 0.6 0.8 1.9 -0.9 -0.9 -0.5 1.4 -0.9 0.8 -0.4
Medication: Simvastatin 1.8 2.7 5.1 -1.7 -1.9 -2.3 -1.1 -1.8 1.1 -1.3
Fluid intelligence score 2.6 5.4 8.2 2.6 1.6 2.3 1.8 2.9 -2.0 2.8
Illnesses of siblings 1.5 2.1 4.8 2.2 0.8 0.8 0.0 1.4 -1.9 1.8
Neuroticism score 0.1 0.3 0.7 0.3 0.1 -0.4 0.7 0.5 0.8 0.5
Weight 3.1 15.4 25.7 5.1 -0.1 2.2 4.2 3.1 -5.0 5.0
Impedance of arm (right) 1.1 5.4 14.9 -3.9 -0.2 -1.9 -2.0 -1.1 1.0 -3.6
Arm fat percentage (right) 1.3 5.3 22.7 -1.3 -2.3 -4.8 -1.3 -2.1 -0.1 -1.0
Trunk fat-free mass 9.2 52.7 78.5 8.9 2.4 8.2 7.2 6.6 -7.1 8.4
Hip circumference 1.9 8.3 16.0 4.0 -0.3 0.5 2.9 2.0 -4.0 3.7
Time employed in main current job 1.1 1.2 2.3 -1.3 -0.5 -1.5 -1.0 -1.0 0.4 -1.5
Alcohol intake versus 10 years previously 3.1 4.7 7.0 1.7 2.7 1.9 2.4 2.4 -1.8 2.1
Father’s age at death 0.1 0.1 0.4 0.4 -0.6 0.0 0.4 0.3 0.3 0.0
Worrier / anxious feelings 0.7 1.4 3.1 -1.5 0.4 -1.0 1.8 0.4 1.3 -1.2
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 2.9 0.2 0.5 0.8 1.7 0.8 -0.7 0.4
Falls in the last year 0.7 0.9 3.4 0.4 0.0 -1.2 -1.8 -0.7 -0.9 0.0
Hair/balding pattern: Pattern 3 0.8 1.2 1.8 1.2 1.3 1.1 -0.1 1.1 -1.3 0.8
Number of live births 1.1 1.5 2.5 0.4 -1.5 -1.4 -1.6 -1.4 1.3 -0.1
Forced expiratory volume in 1-second (FEV1) 17.3 58.4 112.4 7.9 5.2 10.6 7.2 7.6 -6.8 7.2
Pulse rate 1.0 1.7 4.9 -2.2 -0.1 -1.1 -0.8 -1.2 0.4 -1.7
Happiness 0.8 1.0 3.3 0.6 1.5 1.8 0.3 0.8 -0.5 0.6
Noisy workplace 0.4 0.4 0.8 -0.9 -0.7 -0.2 0.6 -0.2 0.9 -0.8
Qualifications: A levels/AS levels or equivalent 0.2 0.4 1.0 -0.5 -0.2 1.0 0.5 0.1 0.9 -0.8
Serious illness, injury or assault of a close relative in last 2 years 2.9 3.4 8.1 1.3 1.7 2.9 2.0 2.1 -1.0 1.3
Mouth/teeth dental problems: Dentures 0.0 0.1 0.2 -0.2 -0.3 -0.3 -0.0 -0.4 0.2 0.1
Asthma 12.3 24.3 31.1 -4.4 -3.8 -5.5 -5.6 -5.4 4.9 -4.6
Medication: Ibuprofen (e.g. Nurofen) 1.9 2.4 4.5 -0.9 -2.1 -2.0 -0.7 -1.3 1.9 -1.2
Medication: Cholesterol lowering 1.2 1.8 5.9 -0.8 -1.7 -2.4 -0.0 -1.2 1.2 -0.5
Depression (self-reported) 1.0 1.2 1.8 1.2 1.0 0.8 1.2 1.2 -0.5 1.3
Medication: Lansoprazole 0.3 0.4 1.4 -0.4 0.3 -0.2 1.2 0.3 -0.8 0.2
Prospective memory result 2.3 2.9 4.4 -1.8 -1.4 -2.1 -1.0 -1.6 1.9 -1.9
Lung cancer (father) 0.7 0.9 4.4 0.3 0.1 0.3 2.1 1.0 -0.4 0.5
Illnesses of mother 0.5 0.7 1.4 0.1 1.1 1.2 0.6 0.7 -1.0 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 18.6 59.3 114.5 7.9 5.0 10.7 7.6 7.7 -6.7 7.2
Pulse wave Arterial Stiffness index 1.0 1.1 3.8 1.1 0.5 0.9 0.1 0.9 -2.0 1.1
Impedance of arm (left) 0.8 3.8 10.0 -3.2 0.1 -1.8 -1.6 -0.8 0.4 -3.1
Arm fat mass (right) 0.6 2.4 4.8 1.5 -1.6 -1.9 1.0 0.0 -2.2 1.6
Trunk predicted mass 9.1 52.2 77.8 8.8 2.4 8.2 7.2 6.6 -7.0 8.3
Standing height 9.8 97.0 151.3 10.2 4.5 12.3 9.9 9.8 -10.9 9.5
Length of working week for main job 0.1 0.1 0.3 -0.0 -0.2 0.4 0.6 -0.1 -0.3 0.4
Exposure to tobacco smoke at home 0.7 0.8 2.9 1.7 -0.4 -0.7 -0.5 -0.2 -0.7 1.2
Breastfed as a baby 0.8 1.0 2.1 -1.2 -0.6 -1.3 -1.0 -0.6 0.8 -1.4
Tense / ‘highly strung’ 0.1 0.1 0.3 -0.1 -0.2 0.1 0.5 0.0 0.5 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.7 2.6 6.4 1.9 2.5 0.6 0.1 1.6 -1.2 1.9
Hair/balding pattern: Pattern 4 2.5 6.1 12.7 1.2 2.8 2.9 3.6 2.5 -1.6 2.0
Birth weight of first child 7.9 14.3 26.4 3.8 3.1 5.1 3.6 3.6 -3.0 3.7
Peak expiratory flow (PEF) 8.3 19.2 40.4 3.7 3.4 6.4 4.6 4.6 -3.7 3.4
Pulse wave reflection index 1.1 1.3 3.1 1.8 -0.1 1.2 -0.4 1.1 -0.9 1.7
Ever highly irritable/argumentative for 2 days 0.4 0.4 1.0 1.0 0.5 1.0 0.4 0.6 -0.0 0.7
Loud music exposure frequency 0.1 0.1 0.4 -0.3 0.2 -0.6 -0.3 -0.3 -0.2 -0.4
Qualifications: O levels/GCSEs or equivalent 1.5 2.4 5.0 1.3 1.2 2.2 1.7 1.8 -0.8 1.4
Mouth/teeth dental problems: Bleeding gums 0.3 0.3 0.7 -0.8 -0.2 -0.0 -0.9 -0.4 0.7 -0.6
Blood clot in the leg (DVT) 0.5 0.6 1.3 -0.9 -1.2 -0.4 0.4 -0.8 0.1 -1.1
Medication: Paracetamol 1.4 2.4 5.3 -1.2 -1.9 -2.3 -0.7 -1.5 1.5 -1.2
Headache pain in last month 0.3 0.5 1.1 -0.3 -1.1 -0.9 0.7 -0.4 0.8 -0.1
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 4.2 0.4 0.8 2.1 -0.8 0.3 -0.5 0.2
Glaucoma (self-reported) 0.2 0.2 0.7 -0.2 0.4 -0.2 0.9 0.4 -0.5 -0.1
Gout (self-reported) 1.3 1.8 3.1 -1.3 -1.8 -1.5 0.5 -1.1 1.7 -1.0
Hypothyroidism/myxoedema (self-reported) 5.8 11.4 20.4 3.9 2.0 0.6 3.7 3.9 -3.3 4.5
Medication: Amlodipine 0.5 0.7 1.8 -0.9 -0.6 -0.9 1.3 -0.3 1.0 -0.3
Medication: Ventolin 100micrograms inhaler 6.6 8.5 10.5 -3.2 -2.5 -2.8 -2.5 -2.9 3.2 -3.2
Birth weight 4.8 10.4 20.5 3.4 2.2 4.5 2.6 3.6 -2.6 3.1
Chronic bronchitis/emphysema (mother) 4.4 5.2 7.6 -2.8 -2.3 -1.9 -1.9 -2.5 2.0 -2.4
High blood pressure (siblings) 1.1 1.5 3.7 -1.2 -0.9 -0.8 0.3 -1.5 1.9 -1.3
Forced vital capacity (FVC), Best measure 10.9 40.0 86.7 6.5 4.0 9.3 5.7 6.2 -5.5 5.8
Body fat percentage 0.9 3.6 16.6 -0.5 -2.3 -4.1 -0.3 -1.4 -1.1 -0.3
Leg fat percentage (right) 0.8 2.9 13.9 -0.1 -1.8 -3.7 -0.4 -1.4 -0.9 0.2
Arm fat-free mass (right) 7.4 37.9 61.2 7.8 1.5 6.6 6.0 5.2 -6.5 7.3
Exposure to tobacco smoke outside home 0.3 0.4 0.7 0.7 -0.7 0.1 0.6 0.3 -0.9 0.8
Comparative body size at age 10 0.3 0.9 2.3 1.5 0.0 -0.2 -1.2 -0.5 -0.5 1.3
Number of full brothers 0.5 0.6 1.0 1.0 -0.8 -0.5 1.0 0.4 0.6 0.9
Worry too long after embarrassment 0.3 0.5 1.6 -0.8 0.3 -0.0 1.3 0.6 0.9 -0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 3.1 -0.3 -0.6 -0.5 0.1 -0.7 1.8 -0.8
Wheeze or whistling in the chest in last year 6.5 11.6 14.8 -3.4 -2.7 -3.6 -3.5 -3.8 3.1 -3.6
Number of children fathered 0.3 0.3 0.7 -0.5 -0.8 0.6 0.8 -0.1 0.3 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 1.5 -0.1 -0.5 -0.2 -1.2 -0.3 0.3 -0.4
Age at first live birth 0.4 0.7 1.8 -1.4 0.4 0.3 1.0 0.3 0.8 -1.1
Pulse wave peak to peak time 0.3 0.4 1.7 -0.4 -0.4 -0.2 0.4 -0.3 1.3 -0.5
Health satisfaction 2.0 2.6 5.1 -1.5 -1.5 -1.4 -1.3 -2.2 1.3 -1.8
Shortness of breath walking on level ground 0.4 0.4 1.3 -0.2 -0.9 -1.2 -0.3 -0.6 -0.5 0.1
Qualifications: College or University degree 0.2 0.8 1.9 1.0 -0.1 1.3 0.5 1.4 -0.3 0.8
Eye problems/disorders: None of the above 0.9 1.0 2.4 1.6 0.9 0.6 0.2 1.2 -0.5 1.4
Mouth/teeth dental problems: Loose teeth 0.6 0.7 2.0 0.1 -0.6 -1.3 -1.4 -0.7 0.1 -0.2
Emphysema/chronic bronchitis 0.6 0.7 1.5 -1.0 -0.8 -1.2 0.0 -0.9 0.0 -0.9
Medication for pain relief, constipation, heartburn 3.6 6.1 12.4 2.1 3.5 3.5 -0.1 2.2 -2.4 1.8
Neck or shoulder pain in last month 0.3 0.4 1.2 0.4 -0.9 -0.4 -0.4 -0.3 1.1 0.2
Medication: Blood pressure 1.4 2.5 5.6 -1.3 -1.8 -2.4 0.5 -1.3 1.9 -1.2
Angina (self-reported) 0.7 0.9 1.5 -0.9 -1.2 -1.2 0.7 -1.1 0.8 -0.7
Migraine (self-reported) 0.8 1.0 3.4 -0.6 -0.6 -1.9 -1.6 -0.6 -0.1 -0.4
Medication: Ibuprofen 1.5 1.8 4.2 -0.9 -2.0 -1.6 -0.3 -1.1 1.5 -1.2
Medication: Allopurinol 1.5 1.9 3.4 -1.9 -1.4 -1.5 0.8 -1.1 1.5 -1.4
Medication: Omeprazole 0.8 1.0 3.2 -0.6 -1.8 -1.6 0.5 -0.5 0.3 -0.2
Medication: Seretide 50 evohaler 5.6 6.4 9.6 -2.9 -2.0 -3.1 -2.4 -2.4 1.7 -2.8
Mean time to correctly identify matches 0.2 0.4 1.2 -0.3 0.2 -1.0 -1.1 -0.5 -0.1 -0.2
Heart disease (mother) 2.2 2.7 5.8 -1.8 -2.4 -1.2 0.3 -1.6 1.8 -1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 1.2 -0.2 -0.7 -1.1 0.3 -0.0 1.0 0.1
Whole body fat mass 0.9 3.7 9.3 2.1 -1.4 -1.2 1.8 0.7 -3.0 2.2
Leg fat mass (right) 0.9 3.4 7.4 2.1 -1.2 -1.2 1.7 0.6 -2.7 2.3
Arm predicted mass (right) 7.8 40.0 66.3 8.1 1.5 6.7 6.1 5.5 -6.5 7.6
Pulse rate, automated reading 2.3 7.5 14.4 -3.8 -1.4 -1.8 -1.9 -2.8 2.7 -3.8
Alcohol intake frequency. 0.1 0.3 1.0 1.0 0.0 0.0 -0.5 0.2 -0.4 0.7
Comparative height size at age 10 7.3 39.9 62.6 6.9 2.6 7.9 5.7 6.4 -7.0 6.4
Number of full sisters 0.5 0.6 1.1 0.8 -0.4 0.7 1.0 0.7 -0.7 1.0
Suffer from ‘nerves’ 0.2 0.3 0.8 -0.6 0.2 -0.1 0.0 -0.4 0.9 -0.7
Overall health rating 1.1 2.4 4.0 -1.5 -1.7 -2.0 -0.5 -2.0 0.9 -1.5
Chest pain or discomfort 0.5 0.7 1.6 -0.5 -1.2 0.0 0.2 -1.3 1.0 -0.7
Had major operations 5.1 6.0 8.9 2.3 2.1 3.0 2.7 2.5 -1.8 2.6
Age at last live birth 0.9 1.3 3.3 0.5 1.0 1.2 1.8 1.4 -0.4 0.9
Family relationship satisfaction 1.6 1.9 3.3 1.6 1.8 1.4 -0.4 0.9 -1.3 1.7
Leg pain on walking 0.9 1.1 3.6 -0.6 -1.9 -1.0 0.1 -1.0 1.3 -0.4
Qualifications: NVQ or HND or HNC or equivalent 1.7 2.1 5.3 -1.1 -0.8 -2.3 -1.8 -1.5 0.8 -1.1
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.9 -0.5 0.3 -0.0 0.9 0.2 -0.2 -0.3
Illness, injury, bereavement, stress in last 2 years 4.4 5.3 7.2 -1.5 -2.5 -2.7 -2.1 -2.6 2.5 -1.9
Medication: Aspirin 0.4 0.5 1.5 -0.3 -1.2 -0.9 1.0 -0.5 0.1 0.0
Supplements: Vitamin C 0.2 0.3 0.6 -0.3 0.6 -0.2 0.5 0.4 -0.8 -0.5
Knee pain experienced in last month 2.7 4.2 7.4 -2.0 -2.7 -2.0 -1.3 -2.2 1.9 -2.0
Hypertension (Self-reported) 1.1 3.1 6.9 -1.9 -1.8 -2.6 -0.6 -1.7 1.8 -1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 2.0 -1.4 -0.9 -1.3 1.1 -0.3 0.7 -0.6
Illnesses of father: Heart disease 2.8 3.9 6.7 -2.6 -1.3 -2.2 -1.7 -2.2 1.4 -2.1
Illnesses of siblings: Diabetes 1.4 1.7 3.8 0.4 1.1 1.9 2.0 1.3 -0.8 1.0
Smoking status: Previous 0.8 1.1 4.8 -0.5 -0.1 -1.2 -2.2 -1.1 -0.4 -0.5
Forced expiratory volume in 1-second (FEV1), predicted 18.2 37.9 53.1 5.5 3.8 7.3 6.8 6.7 -6.3 6.0
Whole body fat-free mass 7.0 40.2 63.2 8.0 1.6 6.8 6.2 5.6 -6.6 7.5
Leg fat-free mass (right) 4.1 21.8 36.5 6.0 0.6 4.3 4.5 4.0 -5.3 5.7
Arm fat percentage (left) 1.2 4.9 21.7 -1.0 -2.2 -4.7 -1.3 -2.0 -0.3 -0.8
Average weekly red wine intake 0.3 0.5 1.2 -0.8 -0.4 -0.6 -0.6 -0.8 -0.1 -1.1
Handedness (chirality/laterality): Left-handed 1.3 1.6 3.7 -1.9 -1.1 -0.5 -0.9 -1.0 1.1 -1.7
Mood swings 0.2 0.3 0.9 -0.3 -0.6 -0.9 0.3 0.1 0.9 0.1
Loneliness, isolation 0.3 0.4 1.7 0.1 -0.4 -1.3 -0.4 -0.7 0.5 0.1
Long-standing illness, disability or infirmity 1.1 1.7 5.2 -1.1 -1.7 -2.3 0.4 -0.9 0.7 -0.8
Ever had bowel cancer screening 0.3 0.3 0.8 -0.3 -0.5 -0.7 -0.6 -0.9 0.4 -0.5
Diabetes diagnosed by doctor 2.1 3.5 5.8 0.9 1.9 2.2 2.4 1.9 -1.8 1.6
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 1.3 -0.4 -1.1 -0.9 -1.0 -0.8 1.1 -0.6
Friendships satisfaction 0.2 0.2 0.4 0.6 0.5 0.5 -0.6 -0.4 0.2 0.1
Qualifications: nursing, teaching 1.5 2.3 4.1 1.6 1.5 2.0 1.1 1.6 -0.8 1.7
Commuting to job workplace: Walk 0.2 0.2 0.7 -0.3 -0.2 0.0 -0.8 -0.4 0.2 -0.8
Eye problems/disorders: Cataract 1.4 1.6 2.8 -1.7 -1.0 -0.7 -1.3 -1.7 0.8 -1.4
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 1.6 -0.9 -0.9 -0.6 -0.9 -0.8 1.3 -0.8
Medication for cholesterol 0.3 0.5 1.2 1.0 1.1 0.4 0.4 0.8 -0.2 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.1 4.2 -0.7 -1.3 -2.1 -0.2 -0.6 0.8 -0.8
Back pain experienced in last month 0.5 0.7 2.6 -0.5 -0.7 -0.6 1.6 0.7 -0.9 -0.1
Mineral and other dietary supplements 1.4 1.8 5.3 2.0 1.3 -0.1 0.4 1.1 -0.9 2.3
Breast cancer (self-reported) 0.2 0.3 0.6 0.3 0.6 0.8 0.4 0.8 0.1 0.1
Asthma (self-reported) 12.4 24.6 31.4 -4.6 -3.7 -5.6 -5.5 -5.5 4.8 -4.8
Osteoporosis (self-reported) 1.9 2.4 5.0 -2.2 -1.1 -1.0 -0.9 -1.6 1.3 -2.1
Osteoarthritis (self-reported) 8.1 10.5 12.5 -2.8 -3.5 -3.2 -3.0 -3.5 3.3 -3.4
Medication: Aspirin 0.4 0.5 1.5 -0.2 -1.2 -0.9 0.6 -0.7 0.3 -0.0
Medication: Gliclazide 0.3 0.4 1.2 0.3 0.3 1.1 0.7 0.6 -0.6 0.2
Illnesses of father: None of the above (group 1) 1.2 1.5 2.4 1.6 0.4 0.9 1.4 1.5 -1.1 1.4
Smoking status: Current 0.2 0.3 0.8 0.4 -0.9 -0.5 0.2 0.5 -0.2 0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 6.0 12.7 29.1 3.6 2.8 5.4 3.2 3.7 -2.5 3.1
Whole body water mass 7.1 40.3 63.4 8.0 1.7 6.8 6.2 5.6 -6.6 7.5
Leg predicted mass (right) 4.0 21.2 35.7 6.0 0.6 4.2 4.5 3.9 -5.3 5.6
Arm fat mass (left) 0.7 2.9 6.9 2.0 -1.3 -1.5 1.2 0.4 -2.6 2.0
Number of self-reported non-cancer illnesses 3.2 5.6 15.1 -1.9 -2.2 -3.9 -1.5 -2.4 2.0 -1.7
Average weekly champagne plus white wine intake 0.4 0.6 1.4 -1.2 0.1 -0.8 -0.3 -0.4 0.6 -1.1
Miserableness 0.5 0.9 1.7 1.0 0.3 0.8 1.1 1.3 -0.2 1.1
Guilty feelings 0.2 0.3 0.8 0.6 0.9 -0.0 -0.1 0.5 0.2 0.6
Wears glasses or contact lenses 0.3 0.3 0.9 -0.3 -0.2 -0.6 0.9 0.9 -0.2 0.1
Ever taken oral contraceptive pill 1.8 2.0 3.3 0.4 1.5 1.6 1.7 1.8 -1.4 0.9
Hearing aid user 0.6 0.7 2.1 -1.1 -0.1 -1.4 -0.8 -0.4 -0.5 -0.7
Mother’s age at death 0.3 0.4 1.4 0.1 0.7 0.3 -0.2 0.8 -1.2 -0.0
Financial situation satisfaction 1.5 1.8 4.4 2.1 1.6 0.6 0.1 0.8 -1.2 1.9
Tinnitus: Yes, now most or all of the time 3.8 4.4 7.7 1.4 1.1 2.8 2.6 2.3 -2.2 1.7
Commuting to job workplace: Public transport 1.4 1.6 2.8 1.3 1.0 1.7 1.2 1.2 -0.6 1.6
Eye problems/disorders: Glaucoma 0.5 0.6 1.5 -1.2 -0.3 -0.4 1.2 0.0 0.1 -0.9
Medication: Blood pressure 0.2 0.4 1.3 -0.8 -0.8 -1.2 0.2 -0.6 0.3 0.0
Pain type(s) experienced in last month: Hip pain 1.6 2.1 4.9 -1.2 -2.2 -1.9 -0.5 -1.3 0.9 -1.3
Supplements: Fish oil (including cod liver oil) 1.6 2.0 4.5 -1.7 -1.1 -0.8 -1.2 -1.6 1.1 -2.1
High cholesterol (Self-reported) 3.1 5.4 12.4 -1.4 -2.5 -3.5 -2.4 -2.5 1.7 -1.6
Medication: Bendroflumethiazide 1.3 2.0 4.4 -1.8 -0.8 -2.1 -1.2 -1.3 1.1 -1.3
Medication: Paracetamol 2.3 3.5 5.5 -1.9 -2.0 -2.3 -0.9 -2.1 1.6 -1.9
Medication: Lisinopril 1.7 2.1 4.9 -2.2 -0.8 -1.6 -1.1 -1.3 1.3 -1.5
Medication: Atorvastatin 1.0 1.3 2.4 -1.4 -0.9 -1.6 -1.0 -1.3 0.6 -0.9
Illnesses of father: High blood pressure 0.6 0.7 2.2 0.5 1.5 0.9 0.1 0.5 -1.0 0.5
Alcohol drinker status: Never 0.9 1.1 2.4 0.4 1.3 1.5 0.6 0.8 -1.4 0.5
Ever smoked 1.2 2.1 5.4 1.6 1.4 0.2 -1.1 0.8 -2.3 1.7
Basal metabolic rate 6.2 34.5 55.4 7.4 1.2 5.7 5.9 5.1 -6.4 7.0
Leg fat percentage (left) 1.2 4.4 19.1 -0.7 -2.3 -4.4 -1.1 -2.0 -0.6 -0.3
Arm fat-free mass (left) 6.8 34.7 59.3 7.7 1.1 6.1 5.8 5.0 -6.0 7.1
Number of operations (self-reported) 2.2 3.3 6.2 2.3 0.8 2.1 1.5 1.7 -1.3 2.5
Average weekly beer plus cider intake 0.5 0.7 1.3 0.5 0.6 1.0 1.1 1.1 -0.3 0.7
Irritability 2.4 4.0 8.6 -1.6 -2.9 -1.8 -1.0 -1.6 2.7 -1.6
Risk taking 2.0 2.9 7.0 2.6 0.9 0.5 0.1 1.4 -1.9 2.6
Ever had prostate specific antigen (PSA) test 2.5 2.9 4.4 -1.2 -1.8 -1.4 -1.7 -1.8 2.1 -1.8
Fractured/broken bones in last 5 years 0.5 0.6 2.4 0.2 1.0 -0.5 -0.2 0.6 -1.6 0.4
Age started oral contraceptive pill 0.4 0.5 1.3 -0.8 0.1 -0.9 -0.6 -0.8 0.0 -1.1
Diastolic blood pressure, automated reading 4.0 12.3 17.9 -4.1 -2.6 -4.2 -2.8 -3.7 2.9 -3.9
Ever depressed for a whole week 1.4 1.7 4.1 0.8 2.0 1.5 1.6 1.2 -0.8 0.6
Unable to work because of sickness or disability 0.6 0.7 2.4 -0.4 -0.9 -1.6 -0.4 -1.2 0.0 -0.4
Commuting to job workplace: Cycle 1.3 1.5 4.5 0.5 1.4 2.1 1.6 1.3 0.0 0.4
Myopia 0.5 0.8 2.3 -1.1 0.1 -0.5 -1.5 -0.4 0.9 -0.7
Vascular/heart problems diagnosed by doctor 1.1 2.9 7.7 2.1 1.5 2.8 0.1 1.5 -1.4 1.3
Cholesterol lowering medication 3.1 4.6 7.5 -2.0 -2.2 -2.3 -2.7 -2.6 1.0 -1.6
Medication: Omeprazole (e.g. Zanprol) 1.2 1.4 3.7 -1.0 -1.9 -1.9 -0.1 -0.9 0.6 -0.6
Pain experienced in last month 0.6 1.1 2.9 0.9 1.7 1.6 -0.3 0.6 -0.9 0.5
Supplements: Calcium 0.6 0.7 1.7 -0.5 0.7 1.2 1.3 0.5 -0.7 -0.5
Basal cell carcinoma (self-reported) 3.8 4.5 5.9 1.8 2.0 2.4 2.4 2.1 -2.3 1.8
Heart attack/myocardial infarction (self-reported) 1.3 1.6 4.7 -0.8 -2.2 -1.9 0.3 -1.2 0.7 -0.8
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.0 -0.8 -1.0 -0.3 0.6 -0.7 -0.1 -0.9
Heart disease (siblings) 1.9 2.3 4.8 -1.7 -2.2 -1.3 -0.5 -1.5 1.3 -1.6
Alcohol drinker status: Previous 0.4 0.5 1.6 -0.5 -0.8 -1.2 -0.4 -0.6 -0.1 -0.6
Pack years of smoking 0.3 0.4 1.5 0.2 -0.7 -1.2 -0.3 -0.7 0.5 0.3
Impedance of whole body 0.5 2.4 7.4 -2.7 0.1 -1.1 -1.1 -0.4 0.3 -2.6
Leg fat mass (left) 0.7 2.9 6.2 1.9 -1.5 -1.5 1.3 0.2 -2.5 2.0
Arm predicted mass (left) 6.7 34.2 57.8 7.6 1.1 6.0 5.8 5.0 -6.0 7.1