Hub : Genes

ZNF76

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.1460	0.0470	6.1e-05	0.137	NA	0.123	NA	0.122	1.2e-06	NA	4.4e-06	NA	4.7e-06
2	METSIM	Adipose	0.1145	0.0374	1.8e-09	0.069	0.064	0.052	0.062	0.064	1.5e-10	6.3e-10	2.7e-08	1.2e-09	6.7e-10
3	NTR	Blood	0.0099	0.0051	4.9e-03	0.003	0.003	0.000	0.002	0.001	4.2e-02	3.8e-02	3.5e-01	4.9e-02	1.0e-01
4	ROSMAP	Brain Pre-frontal Cortex	0.0360	0.0164	1.2e-03	0.004	0.018	0.003	0.015	0.007	1.0e-01	2.1e-03	1.1e-01	4.3e-03	3.4e-02
5	YFS	Blood	0.0473	0.0121	0.0e+00	0.077	0.060	0.071	0.071	0.073	6.3e-24	4.6e-19	3.6e-22	3.6e-22	6.7e-23
6	TCGA	Liver Hepatocellular Carcinoma	0.0760	0.0460	2.3e-03	0.053	0.046	0.054	NA	0.066	1.6e-03	3.1e-03	1.5e-03	NA	4.9e-04
7	TCGA	Prostate Adenocarcinoma	0.0300	0.0212	2.2e-03	0.022	0.012	0.016	NA	0.020	2.0e-03	1.7e-02	6.9e-03	NA	3.5e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.1	0.1	0.6	0.4	-0.8	-0.4	-0.1	-0.3	-0.0	0.1
Bipolar Disorder or Schizophrenia	0.3	0.7	1.5	0.7	0.0	1.1	1.2	0.9	-0.8	0.5
Depressed Affect (Nagel 2018)	0.1	0.3	0.9	-0.5	-0.5	-0.9	0.2	-0.2	0.7	-0.0
Depression (Nagel 2018)	0.2	0.3	0.5	-0.7	0.3	0.7	0.6	-0.1	0.4	-0.4
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.0	1.1	-0.6	1.1	0.5	1.1	-0.1	1.4
Neuroticism (Nagel 2018)	0.4	1.0	2.8	-1.4	-0.2	-0.6	1.0	-0.2	1.7	-0.9
Schizophrenia (2018)	0.7	1.4	3.2	0.6	0.7	1.8	1.7	1.3	-0.9	0.5
Schizophrenia vs Biploar Disorder	0.3	0.4	1.7	0.3	0.4	0.5	1.3	0.7	-0.1	0.4
Worry (Nagel 2018)	0.9	1.8	4.3	-2.1	0.1	-0.7	0.4	-0.7	2.0	-1.8
Alzheimer’s Disease (in mother)	2.3	2.7	5.1	1.2	1.0	1.9	2.3	2.1	-0.7	1.6
Alzheimer’s Disease (in father)	0.8	0.8	2.0	0.6	0.9	1.4	0.9	1.0	-0.3	0.8
Alzheimer’s Disease (including proxy)	2.2	3.1	5.2	1.6	1.4	2.3	1.9	2.0	-0.7	2.0
Crohns Disease (2017)	0.3	0.6	1.8	0.3	1.3	0.8	1.3	0.6	-0.2	0.2
Irritable Bowel Disease (IBD)	0.3	0.8	2.6	-0.9	0.9	0.5	1.6	0.6	0.7	-0.4
Ulcerative Colitis (UC)	1.0	1.9	5.0	-2.2	-0.3	-0.7	0.9	-0.4	2.0	-1.7
Major Depression (MDD)	0.5	0.6	2.0	-0.6	0.9	-0.5	-1.4	-0.6	-0.4	-0.3
Reaction Time	0.4	0.9	3.1	-0.7	-0.1	-1.8	-1.3	-0.7	0.1	-0.4
Verbal and Numeric Reasoning (VNR)	1.2	2.8	5.5	1.6	0.4	2.3	1.3	2.1	-0.9	2.0
Breast Cancer	0.3	0.7	1.5	0.2	0.1	0.9	1.0	1.2	-1.0	0.8
Ovarian Cancer	0.1	0.1	0.4	-0.2	-0.5	0.1	-0.2	0.0	0.6	-0.5
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.3	0.4	1.6	-1.2	0.9	-0.1	-0.1	0.1	0.3	-0.7
Bipolar Disorder (2011)	0.2	0.2	1.0	-0.3	-0.3	0.1	0.2	0.2	-1.0	-0.3
Body Mass Index (BMI) (2010)	0.3	0.4	1.2	1.1	0.0	-0.5	0.3	-0.3	-0.8	0.6
Coronary Artery Disease (CAD)	0.6	0.7	3.0	-0.5	-1.1	-1.7	-0.0	-0.3	0.3	0.0
Crohns Disease (2012)	0.7	1.1	2.1	0.6	1.5	1.4	1.1	1.1	-0.6	0.7
Mean Putamen Volume	2.8	3.2	5.2	1.8	2.1	0.9	-0.0	2.0	-2.3	2.2
Fasting Glucose	0.6	0.7	1.6	1.2	-0.7	0.9	0.6	-0.2	0.5	1.2
HbA1C	1.6	1.8	3.5	0.4	0.9	0.7	1.8	1.8	-1.9	0.9
HDL Cholesterol	2.6	4.3	15.9	-1.1	-0.8	-0.9	-4.0	-2.0	2.1	-1.8
LDL Cholesterol	2.6	4.1	8.3	-0.9	-1.5	-2.5	-2.9	-2.4	1.7	-1.4
Lupus	7.9	11.9	21.9	-2.4	-2.6	-4.7	-3.5	-4.2	3.0	-3.2
Neuroticism (2016)	0.3	0.5	1.1	-0.9	0.3	-0.5	-1.1	-0.5	0.5	-0.6
Primary Biliary Cirrhosis	2.6	3.7	6.8	-1.1	-2.4	-2.6	-2.2	-1.9	1.5	-1.3
Rheumatoid Arthritis	0.7	0.9	2.1	1.4	0.7	0.7	1.3	0.6	-0.4	1.1
Schizophrenia (2014)	0.4	0.8	1.9	0.7	0.3	1.2	1.4	0.9	-0.9	0.5
Triglycerides	0.9	1.4	6.7	0.1	-2.6	-0.5	-0.6	-1.3	1.0	-0.4
Type 2 Diabetes (T2D) (2012)	3.0	3.4	8.0	-2.8	-1.3	-0.8	-0.7	-1.9	1.9	-2.5
Ulcerative Colitis	1.6	2.3	5.5	-2.1	-1.5	-0.6	-0.0	-1.0	2.3	-1.7
Blood Eosinophil Count	1.8	14.2	40.9	-6.4	-2.1	-5.1	-0.4	-2.0	1.7	-4.6
Blood Platelet Count	0.8	9.4	25.6	-3.3	5.1	2.7	3.4	2.6	-1.4	-1.2
Blood Red Count	0.3	3.1	8.6	1.9	2.9	1.6	0.7	1.1	-0.7	2.1
Blood White Count	9.5	70.6	92.2	6.0	9.6	8.0	8.9	9.4	-8.6	7.7
Heel T-Score	2.8	22.1	49.3	2.7	4.0	6.2	7.0	4.8	-2.8	3.6
BMI	0.5	2.8	10.6	1.0	-1.8	-3.2	0.8	-0.7	-1.0	1.6
Height	8.5	164.2	246.5	13.6	5.0	15.7	13.2	12.9	-14.0	12.5
Waist Hip Ratio (WHR)	0.5	2.5	4.9	-1.7	2.0	2.2	1.6	0.5	-1.4	-0.7
Systolic Blood Pressure	2.0	10.0	23.1	-4.8	-0.2	-3.6	-1.9	-2.6	2.6	-4.1
Smoking Status	0.4	1.0	1.7	-1.2	-1.3	-1.3	-1.0	-0.7	-0.4	-0.5
Allergy or Eczema	4.3	11.4	18.0	-3.3	-2.9	-3.2	-1.5	-3.5	4.2	-4.1
Cardiovascular Disease	1.5	5.1	17.6	-2.4	-2.1	-4.2	-1.0	-1.8	1.2	-1.6
Hypothyroidism (self reported)	3.7	8.5	13.7	3.1	2.0	0.2	3.6	3.2	-3.0	3.7
Respiratory disease	13.5	30.0	38.7	-5.5	-4.5	-5.6	-5.3	-6.2	5.4	-5.7
Type 2 Diabetes (T2D) (2018)	1.4	2.6	6.5	0.7	1.2	1.9	2.5	1.5	-1.5	1.3
Lung FEV1/FVC ratio	12.2	61.7	90.2	7.5	5.2	8.7	9.5	8.3	-7.1	7.9
Lung FVC	2.6	13.1	31.8	3.9	3.5	5.6	1.9	3.6	-1.8	3.5
Neuroticism	0.4	0.9	2.0	-1.4	-0.3	-1.0	0.3	-0.5	1.4	-1.0
Chronotype (morning person)	1.6	3.6	6.8	1.9	2.6	1.1	0.5	1.9	-2.4	2.0
Hair Pigment	0.8	22.9	48.3	3.6	3.0	4.9	7.0	5.4	-3.6	4.8
Tanning	0.1	0.7	2.1	-0.5	-1.4	-0.6	-0.5	-0.8	0.7	-0.8
Hand grip strength (left)	4.4	11.5	22.3	3.3	1.5	4.7	4.0	3.7	-2.7	3.0
Number of treatments/medications taken	1.8	3.2	8.8	-2.1	-1.7	-3.0	-0.7	-1.7	1.0	-1.5
Average weekly spirits intake	1.0	1.2	2.8	-1.3	-1.5	-1.7	-0.1	-1.0	0.6	-0.8
Sensitivity / hurt feelings	2.4	4.1	8.6	1.3	1.6	1.9	2.9	2.6	-1.0	2.1
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.2	1.1	0.4	0.8	0.8	0.4	0.3	1.0
Hearing difficulty/problems: Yes	0.8	1.2	2.5	0.5	0.7	0.5	1.3	1.6	-1.6	0.9
Relative age of first facial hair	0.2	0.3	0.8	-0.0	-0.1	0.8	0.8	0.9	-0.6	0.0
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	2.1	-0.0	-1.5	-1.1	0.3	-0.6	-0.1	-0.3
Ever used hormone-replacement therapy (HRT)	2.3	3.0	4.9	-2.2	-1.8	-0.8	-0.7	-2.0	1.8	-2.0
Ever had hysterectomy (womb removed)	2.7	3.0	6.2	-1.8	-2.5	-0.9	-1.2	-2.0	1.4	-1.9
Systolic blood pressure, automated reading	3.7	10.6	20.5	-4.5	-1.1	-3.6	-2.7	-3.1	2.8	-3.9
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.5	0.6	1.2	1.0	0.3	0.6	-1.0	0.6
Angina	0.7	0.9	1.3	-0.9	-1.1	-1.1	0.7	-1.1	0.7	-0.8
Medication for hormone replacement therapy	0.5	0.5	2.2	0.0	0.4	1.5	0.7	0.6	-0.6	0.3
Vitamin and mineral supplements	1.0	1.3	3.1	1.6	0.8	0.5	0.5	1.0	-1.2	1.8
Supplements: Zinc	0.2	0.2	0.5	0.5	-0.6	0.7	0.1	0.3	-0.1	0.1
Medication: Co-codamol	0.6	0.7	2.0	0.1	1.3	-0.3	-1.4	-0.3	-1.1	0.3
Medication: Metformin	1.5	2.1	3.4	1.7	0.5	1.6	1.8	1.3	-1.0	1.7
Diabetes (father)	0.8	1.0	2.2	-0.9	-0.3	-0.7	-1.5	-1.1	0.8	-1.2
Diabetes (mother)	4.4	5.7	7.9	2.8	2.0	2.6	2.3	2.4	-2.1	2.3
Severe depression (siblings)	2.9	3.3	4.4	1.7	2.1	1.6	1.8	1.9	-1.6	2.0
Pack years adult smoking proportion	0.2	0.3	0.8	0.8	-0.1	-0.8	0.0	-0.1	-0.1	0.9
Impedance of leg (right)	0.2	0.8	1.3	-0.9	1.0	1.0	0.9	1.2	-0.5	-0.7
Leg fat-free mass (left)	4.5	24.0	40.7	6.4	0.8	4.4	4.8	4.2	-5.5	6.0
Trunk fat percentage	0.8	3.1	13.0	-0.2	-2.2	-3.6	0.0	-0.9	-1.7	-0.0
Hand grip strength (right)	3.7	10.1	18.8	2.9	1.0	4.3	4.0	3.5	-2.5	2.8
Townsend deprivation index at recruitment	0.7	0.9	3.5	1.9	-0.7	-0.3	0.4	0.1	-0.6	1.5
Current tobacco smoking	0.3	0.5	1.2	0.7	-1.0	-0.5	0.4	0.5	-0.2	1.1
Average weekly fortified wine intake	2.3	2.7	5.3	-1.0	-2.3	-1.3	-1.6	-1.6	1.9	-1.5
Maternal smoking around birth	0.1	0.2	0.5	0.4	-0.7	0.2	0.1	-0.4	0.1	0.7
Fed-up feelings	0.1	0.3	1.1	0.2	-0.4	-1.0	0.2	0.1	0.5	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.0	-1.0	-0.0	0.3	0.7	0.1	0.2	-0.6
Relative age voice broke	0.2	0.3	1.0	0.1	0.4	1.0	0.6	0.7	-0.6	0.1
Taking other prescription medications	0.4	0.6	1.8	-0.7	0.5	-1.0	1.3	0.2	-0.6	0.2
Age when periods started (menarche)	0.1	0.4	1.3	-1.1	-0.4	-0.6	0.1	-0.0	0.4	-0.7
Bilateral oophorectomy (both ovaries removed)	0.6	0.6	2.8	-0.3	0.0	1.0	1.7	0.7	0.3	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	3.6	8.2	17.7	2.2	1.9	2.4	4.2	3.6	-1.7	3.0
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	0.3	0.4	0.3	0.6	-0.2	-0.2	-0.2
Qualifications: CSEs or equivalent	0.7	1.0	3.3	0.4	-0.5	-1.5	-1.8	-0.8	0.4	0.4
Serious illness, injury or assault to yourself	0.2	0.2	0.5	-0.7	0.1	-0.2	0.6	0.4	-0.6	0.0
High blood pressure	0.7	2.0	5.2	-1.6	-1.2	-2.3	-0.0	-1.2	1.6	-1.0
Hayfever, allergic rhinitis or eczema	2.3	5.0	7.7	-2.5	-1.2	-2.1	-1.4	-2.6	2.5	-2.8
Multivitamins +/- minerals	0.2	0.2	0.4	-0.4	-0.0	0.6	-0.1	-0.5	0.6	-0.6
Stomach or abdominal pain in last month	0.8	1.0	2.3	1.3	0.7	0.4	0.6	0.6	-1.5	1.1
Supplements: Glucosamine	2.0	2.6	5.6	-1.9	-1.6	-0.4	-1.4	-1.7	1.3	-2.4
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	5.2	1.1	1.0	2.3	0.7	1.0	-0.9	1.0
Medication: Atenolol	0.7	0.9	3.2	-0.3	-1.2	-1.8	-0.4	-0.8	0.9	-0.2
Medication: Levothyroxine sodium	4.2	7.1	13.8	3.0	1.8	-0.4	2.7	3.1	-2.5	3.7
Sitting height	2.8	19.7	30.4	5.2	0.9	4.9	4.2	3.9	-5.5	4.8
Chronic bronchitis/emphysema (father)	0.2	0.2	0.7	-0.5	-0.4	-0.3	0.8	0.1	0.6	0.0
High blood pressure (mother)	1.0	1.4	2.8	1.7	1.5	0.4	-0.6	1.0	-1.1	1.5
Body mass index (BMI)	0.6	2.5	10.7	0.7	-2.0	-3.3	-0.0	-1.2	-0.4	0.9
Impedance of leg (left)	0.2	0.8	3.1	-1.8	0.3	0.3	0.1	0.3	0.0	-1.5
Leg predicted mass (left)	4.7	24.7	42.0	6.5	0.9	4.4	4.9	4.3	-5.6	6.1
Trunk fat mass	0.9	3.9	11.8	1.9	-1.4	-1.1	1.9	0.8	-3.4	2.1
Waist circumference	1.0	3.7	9.2	2.3	-0.4	-0.1	2.1	0.8	-3.0	2.5
Number of incorrect matches in round	1.2	1.9	4.7	1.2	1.4	0.9	2.2	1.5	-1.2	1.1
Past tobacco smoking	0.5	1.0	4.1	-0.0	0.2	1.1	2.0	0.7	0.9	-0.2
Alcohol usually taken with meals	0.1	0.1	0.3	-0.3	0.5	-0.2	0.2	0.0	0.0	-0.4
Nervous feelings	0.8	1.5	2.6	-1.4	0.0	-1.4	-0.9	-1.0	1.6	-1.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.9	-0.6	0.0	-0.5	-0.6	-0.9	0.9	-0.9
Hearing difficulty/problems with background noise	0.0	0.1	0.2	0.1	0.0	-0.5	-0.1	0.5	-0.0	0.0
Hair/balding pattern: Pattern 2	2.2	2.8	5.3	-1.2	-2.3	-1.3	-1.5	-1.6	2.1	-1.3
Had menopause	1.2	1.5	2.4	-1.3	-0.8	-1.2	-1.2	-1.4	1.0	-1.5
Had other major operations	0.2	0.2	0.6	0.2	0.6	0.3	0.1	0.4	-0.8	0.5
Forced vital capacity (FVC)	10.4	39.9	85.6	6.5	4.2	9.2	5.5	6.2	-5.8	5.8
Heel bone mineral density (BMD) T-score, automated (right)	4.8	11.1	22.4	2.7	2.5	3.2	4.7	4.0	-2.0	3.4
Ever unenthusiastic/disinterested for a whole week	3.1	3.7	10.8	1.2	3.3	2.2	1.4	1.6	-1.9	1.0
Qualifications: None of the above	1.1	2.4	4.0	-1.4	-1.5	-2.0	-1.4	-1.8	0.9	-1.7
Financial difficulties in last 2 years	0.9	1.3	2.8	1.7	0.6	0.2	1.1	1.0	-0.9	1.6
Mouth/teeth dental problems	0.3	0.5	1.0	0.9	0.4	0.5	0.7	0.7	-1.0	0.6
Heart attack	1.5	1.9	5.1	-0.9	-2.3	-1.9	0.3	-1.3	0.9	-0.9
Allergy	6.0	13.9	18.3	3.9	2.8	3.8	2.9	4.3	-4.0	4.2
Pain all over the body in last month	0.6	0.7	2.4	0.3	-0.7	0.7	1.6	0.6	0.3	0.8
Diabetes (self-reported)	0.4	0.7	1.2	0.2	0.8	0.8	1.1	0.8	-0.9	0.8
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.4	0.8	0.6	0.8	1.5	0.8	-0.8	0.9
Medication: Ramipril	0.6	0.8	1.9	-0.9	-0.9	-0.5	1.4	-0.9	0.8	-0.4
Medication: Simvastatin	1.8	2.7	5.1	-1.7	-1.9	-2.3	-1.1	-1.8	1.1	-1.3
Fluid intelligence score	2.6	5.4	8.2	2.6	1.6	2.3	1.8	2.9	-2.0	2.8
Illnesses of siblings	1.5	2.1	4.8	2.2	0.8	0.8	0.0	1.4	-1.9	1.8
Neuroticism score	0.1	0.3	0.7	0.3	0.1	-0.4	0.7	0.5	0.8	0.5
Weight	3.1	15.4	25.7	5.1	-0.1	2.2	4.2	3.1	-5.0	5.0
Impedance of arm (right)	1.1	5.4	14.9	-3.9	-0.2	-1.9	-2.0	-1.1	1.0	-3.6
Arm fat percentage (right)	1.3	5.3	22.7	-1.3	-2.3	-4.8	-1.3	-2.1	-0.1	-1.0
Trunk fat-free mass	9.2	52.7	78.5	8.9	2.4	8.2	7.2	6.6	-7.1	8.4
Hip circumference	1.9	8.3	16.0	4.0	-0.3	0.5	2.9	2.0	-4.0	3.7
Time employed in main current job	1.1	1.2	2.3	-1.3	-0.5	-1.5	-1.0	-1.0	0.4	-1.5
Alcohol intake versus 10 years previously	3.1	4.7	7.0	1.7	2.7	1.9	2.4	2.4	-1.8	2.1
Father’s age at death	0.1	0.1	0.4	0.4	-0.6	0.0	0.4	0.3	0.3	0.0
Worrier / anxious feelings	0.7	1.4	3.1	-1.5	0.4	-1.0	1.8	0.4	1.3	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.9	0.2	0.5	0.8	1.7	0.8	-0.7	0.4
Falls in the last year	0.7	0.9	3.4	0.4	0.0	-1.2	-1.8	-0.7	-0.9	0.0
Hair/balding pattern: Pattern 3	0.8	1.2	1.8	1.2	1.3	1.1	-0.1	1.1	-1.3	0.8
Number of live births	1.1	1.5	2.5	0.4	-1.5	-1.4	-1.6	-1.4	1.3	-0.1
Forced expiratory volume in 1-second (FEV1)	17.3	58.4	112.4	7.9	5.2	10.6	7.2	7.6	-6.8	7.2
Pulse rate	1.0	1.7	4.9	-2.2	-0.1	-1.1	-0.8	-1.2	0.4	-1.7
Happiness	0.8	1.0	3.3	0.6	1.5	1.8	0.3	0.8	-0.5	0.6
Noisy workplace	0.4	0.4	0.8	-0.9	-0.7	-0.2	0.6	-0.2	0.9	-0.8
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.0	-0.5	-0.2	1.0	0.5	0.1	0.9	-0.8
Serious illness, injury or assault of a close relative in last 2 years	2.9	3.4	8.1	1.3	1.7	2.9	2.0	2.1	-1.0	1.3
Mouth/teeth dental problems: Dentures	0.0	0.1	0.2	-0.2	-0.3	-0.3	-0.0	-0.4	0.2	0.1
Asthma	12.3	24.3	31.1	-4.4	-3.8	-5.5	-5.6	-5.4	4.9	-4.6
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.4	4.5	-0.9	-2.1	-2.0	-0.7	-1.3	1.9	-1.2
Medication: Cholesterol lowering	1.2	1.8	5.9	-0.8	-1.7	-2.4	-0.0	-1.2	1.2	-0.5
Depression (self-reported)	1.0	1.2	1.8	1.2	1.0	0.8	1.2	1.2	-0.5	1.3
Medication: Lansoprazole	0.3	0.4	1.4	-0.4	0.3	-0.2	1.2	0.3	-0.8	0.2
Prospective memory result	2.3	2.9	4.4	-1.8	-1.4	-2.1	-1.0	-1.6	1.9	-1.9
Lung cancer (father)	0.7	0.9	4.4	0.3	0.1	0.3	2.1	1.0	-0.4	0.5
Illnesses of mother	0.5	0.7	1.4	0.1	1.1	1.2	0.6	0.7	-1.0	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	18.6	59.3	114.5	7.9	5.0	10.7	7.6	7.7	-6.7	7.2
Pulse wave Arterial Stiffness index	1.0	1.1	3.8	1.1	0.5	0.9	0.1	0.9	-2.0	1.1
Impedance of arm (left)	0.8	3.8	10.0	-3.2	0.1	-1.8	-1.6	-0.8	0.4	-3.1
Arm fat mass (right)	0.6	2.4	4.8	1.5	-1.6	-1.9	1.0	0.0	-2.2	1.6
Trunk predicted mass	9.1	52.2	77.8	8.8	2.4	8.2	7.2	6.6	-7.0	8.3
Standing height	9.8	97.0	151.3	10.2	4.5	12.3	9.9	9.8	-10.9	9.5
Length of working week for main job	0.1	0.1	0.3	-0.0	-0.2	0.4	0.6	-0.1	-0.3	0.4
Exposure to tobacco smoke at home	0.7	0.8	2.9	1.7	-0.4	-0.7	-0.5	-0.2	-0.7	1.2
Breastfed as a baby	0.8	1.0	2.1	-1.2	-0.6	-1.3	-1.0	-0.6	0.8	-1.4
Tense / ‘highly strung’	0.1	0.1	0.3	-0.1	-0.2	0.1	0.5	0.0	0.5	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	6.4	1.9	2.5	0.6	0.1	1.6	-1.2	1.9
Hair/balding pattern: Pattern 4	2.5	6.1	12.7	1.2	2.8	2.9	3.6	2.5	-1.6	2.0
Birth weight of first child	7.9	14.3	26.4	3.8	3.1	5.1	3.6	3.6	-3.0	3.7
Peak expiratory flow (PEF)	8.3	19.2	40.4	3.7	3.4	6.4	4.6	4.6	-3.7	3.4
Pulse wave reflection index	1.1	1.3	3.1	1.8	-0.1	1.2	-0.4	1.1	-0.9	1.7
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.0	1.0	0.5	1.0	0.4	0.6	-0.0	0.7
Loud music exposure frequency	0.1	0.1	0.4	-0.3	0.2	-0.6	-0.3	-0.3	-0.2	-0.4
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	5.0	1.3	1.2	2.2	1.7	1.8	-0.8	1.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	0.7	-0.8	-0.2	-0.0	-0.9	-0.4	0.7	-0.6
Blood clot in the leg (DVT)	0.5	0.6	1.3	-0.9	-1.2	-0.4	0.4	-0.8	0.1	-1.1
Medication: Paracetamol	1.4	2.4	5.3	-1.2	-1.9	-2.3	-0.7	-1.5	1.5	-1.2
Headache pain in last month	0.3	0.5	1.1	-0.3	-1.1	-0.9	0.7	-0.4	0.8	-0.1
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	4.2	0.4	0.8	2.1	-0.8	0.3	-0.5	0.2
Glaucoma (self-reported)	0.2	0.2	0.7	-0.2	0.4	-0.2	0.9	0.4	-0.5	-0.1
Gout (self-reported)	1.3	1.8	3.1	-1.3	-1.8	-1.5	0.5	-1.1	1.7	-1.0
Hypothyroidism/myxoedema (self-reported)	5.8	11.4	20.4	3.9	2.0	0.6	3.7	3.9	-3.3	4.5
Medication: Amlodipine	0.5	0.7	1.8	-0.9	-0.6	-0.9	1.3	-0.3	1.0	-0.3
Medication: Ventolin 100micrograms inhaler	6.6	8.5	10.5	-3.2	-2.5	-2.8	-2.5	-2.9	3.2	-3.2
Birth weight	4.8	10.4	20.5	3.4	2.2	4.5	2.6	3.6	-2.6	3.1
Chronic bronchitis/emphysema (mother)	4.4	5.2	7.6	-2.8	-2.3	-1.9	-1.9	-2.5	2.0	-2.4
High blood pressure (siblings)	1.1	1.5	3.7	-1.2	-0.9	-0.8	0.3	-1.5	1.9	-1.3
Forced vital capacity (FVC), Best measure	10.9	40.0	86.7	6.5	4.0	9.3	5.7	6.2	-5.5	5.8
Body fat percentage	0.9	3.6	16.6	-0.5	-2.3	-4.1	-0.3	-1.4	-1.1	-0.3
Leg fat percentage (right)	0.8	2.9	13.9	-0.1	-1.8	-3.7	-0.4	-1.4	-0.9	0.2
Arm fat-free mass (right)	7.4	37.9	61.2	7.8	1.5	6.6	6.0	5.2	-6.5	7.3
Exposure to tobacco smoke outside home	0.3	0.4	0.7	0.7	-0.7	0.1	0.6	0.3	-0.9	0.8
Comparative body size at age 10	0.3	0.9	2.3	1.5	0.0	-0.2	-1.2	-0.5	-0.5	1.3
Number of full brothers	0.5	0.6	1.0	1.0	-0.8	-0.5	1.0	0.4	0.6	0.9
Worry too long after embarrassment	0.3	0.5	1.6	-0.8	0.3	-0.0	1.3	0.6	0.9	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	3.1	-0.3	-0.6	-0.5	0.1	-0.7	1.8	-0.8
Wheeze or whistling in the chest in last year	6.5	11.6	14.8	-3.4	-2.7	-3.6	-3.5	-3.8	3.1	-3.6
Number of children fathered	0.3	0.3	0.7	-0.5	-0.8	0.6	0.8	-0.1	0.3	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.5	-0.1	-0.5	-0.2	-1.2	-0.3	0.3	-0.4
Age at first live birth	0.4	0.7	1.8	-1.4	0.4	0.3	1.0	0.3	0.8	-1.1
Pulse wave peak to peak time	0.3	0.4	1.7	-0.4	-0.4	-0.2	0.4	-0.3	1.3	-0.5
Health satisfaction	2.0	2.6	5.1	-1.5	-1.5	-1.4	-1.3	-2.2	1.3	-1.8
Shortness of breath walking on level ground	0.4	0.4	1.3	-0.2	-0.9	-1.2	-0.3	-0.6	-0.5	0.1
Qualifications: College or University degree	0.2	0.8	1.9	1.0	-0.1	1.3	0.5	1.4	-0.3	0.8
Eye problems/disorders: None of the above	0.9	1.0	2.4	1.6	0.9	0.6	0.2	1.2	-0.5	1.4
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.0	0.1	-0.6	-1.3	-1.4	-0.7	0.1	-0.2
Emphysema/chronic bronchitis	0.6	0.7	1.5	-1.0	-0.8	-1.2	0.0	-0.9	0.0	-0.9
Medication for pain relief, constipation, heartburn	3.6	6.1	12.4	2.1	3.5	3.5	-0.1	2.2	-2.4	1.8
Neck or shoulder pain in last month	0.3	0.4	1.2	0.4	-0.9	-0.4	-0.4	-0.3	1.1	0.2
Medication: Blood pressure	1.4	2.5	5.6	-1.3	-1.8	-2.4	0.5	-1.3	1.9	-1.2
Angina (self-reported)	0.7	0.9	1.5	-0.9	-1.2	-1.2	0.7	-1.1	0.8	-0.7
Migraine (self-reported)	0.8	1.0	3.4	-0.6	-0.6	-1.9	-1.6	-0.6	-0.1	-0.4
Medication: Ibuprofen	1.5	1.8	4.2	-0.9	-2.0	-1.6	-0.3	-1.1	1.5	-1.2
Medication: Allopurinol	1.5	1.9	3.4	-1.9	-1.4	-1.5	0.8	-1.1	1.5	-1.4
Medication: Omeprazole	0.8	1.0	3.2	-0.6	-1.8	-1.6	0.5	-0.5	0.3	-0.2
Medication: Seretide 50 evohaler	5.6	6.4	9.6	-2.9	-2.0	-3.1	-2.4	-2.4	1.7	-2.8
Mean time to correctly identify matches	0.2	0.4	1.2	-0.3	0.2	-1.0	-1.1	-0.5	-0.1	-0.2
Heart disease (mother)	2.2	2.7	5.8	-1.8	-2.4	-1.2	0.3	-1.6	1.8	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.2	-0.2	-0.7	-1.1	0.3	-0.0	1.0	0.1
Whole body fat mass	0.9	3.7	9.3	2.1	-1.4	-1.2	1.8	0.7	-3.0	2.2
Leg fat mass (right)	0.9	3.4	7.4	2.1	-1.2	-1.2	1.7	0.6	-2.7	2.3
Arm predicted mass (right)	7.8	40.0	66.3	8.1	1.5	6.7	6.1	5.5	-6.5	7.6
Pulse rate, automated reading	2.3	7.5	14.4	-3.8	-1.4	-1.8	-1.9	-2.8	2.7	-3.8
Alcohol intake frequency.	0.1	0.3	1.0	1.0	0.0	0.0	-0.5	0.2	-0.4	0.7
Comparative height size at age 10	7.3	39.9	62.6	6.9	2.6	7.9	5.7	6.4	-7.0	6.4
Number of full sisters	0.5	0.6	1.1	0.8	-0.4	0.7	1.0	0.7	-0.7	1.0
Suffer from ‘nerves’	0.2	0.3	0.8	-0.6	0.2	-0.1	0.0	-0.4	0.9	-0.7
Overall health rating	1.1	2.4	4.0	-1.5	-1.7	-2.0	-0.5	-2.0	0.9	-1.5
Chest pain or discomfort	0.5	0.7	1.6	-0.5	-1.2	0.0	0.2	-1.3	1.0	-0.7
Had major operations	5.1	6.0	8.9	2.3	2.1	3.0	2.7	2.5	-1.8	2.6
Age at last live birth	0.9	1.3	3.3	0.5	1.0	1.2	1.8	1.4	-0.4	0.9
Family relationship satisfaction	1.6	1.9	3.3	1.6	1.8	1.4	-0.4	0.9	-1.3	1.7
Leg pain on walking	0.9	1.1	3.6	-0.6	-1.9	-1.0	0.1	-1.0	1.3	-0.4
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.1	5.3	-1.1	-0.8	-2.3	-1.8	-1.5	0.8	-1.1
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.9	-0.5	0.3	-0.0	0.9	0.2	-0.2	-0.3
Illness, injury, bereavement, stress in last 2 years	4.4	5.3	7.2	-1.5	-2.5	-2.7	-2.1	-2.6	2.5	-1.9
Medication: Aspirin	0.4	0.5	1.5	-0.3	-1.2	-0.9	1.0	-0.5	0.1	0.0
Supplements: Vitamin C	0.2	0.3	0.6	-0.3	0.6	-0.2	0.5	0.4	-0.8	-0.5
Knee pain experienced in last month	2.7	4.2	7.4	-2.0	-2.7	-2.0	-1.3	-2.2	1.9	-2.0
Hypertension (Self-reported)	1.1	3.1	6.9	-1.9	-1.8	-2.6	-0.6	-1.7	1.8	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.0	-1.4	-0.9	-1.3	1.1	-0.3	0.7	-0.6
Illnesses of father: Heart disease	2.8	3.9	6.7	-2.6	-1.3	-2.2	-1.7	-2.2	1.4	-2.1
Illnesses of siblings: Diabetes	1.4	1.7	3.8	0.4	1.1	1.9	2.0	1.3	-0.8	1.0
Smoking status: Previous	0.8	1.1	4.8	-0.5	-0.1	-1.2	-2.2	-1.1	-0.4	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	18.2	37.9	53.1	5.5	3.8	7.3	6.8	6.7	-6.3	6.0
Whole body fat-free mass	7.0	40.2	63.2	8.0	1.6	6.8	6.2	5.6	-6.6	7.5
Leg fat-free mass (right)	4.1	21.8	36.5	6.0	0.6	4.3	4.5	4.0	-5.3	5.7
Arm fat percentage (left)	1.2	4.9	21.7	-1.0	-2.2	-4.7	-1.3	-2.0	-0.3	-0.8
Average weekly red wine intake	0.3	0.5	1.2	-0.8	-0.4	-0.6	-0.6	-0.8	-0.1	-1.1
Handedness (chirality/laterality): Left-handed	1.3	1.6	3.7	-1.9	-1.1	-0.5	-0.9	-1.0	1.1	-1.7
Mood swings	0.2	0.3	0.9	-0.3	-0.6	-0.9	0.3	0.1	0.9	0.1
Loneliness, isolation	0.3	0.4	1.7	0.1	-0.4	-1.3	-0.4	-0.7	0.5	0.1
Long-standing illness, disability or infirmity	1.1	1.7	5.2	-1.1	-1.7	-2.3	0.4	-0.9	0.7	-0.8
Ever had bowel cancer screening	0.3	0.3	0.8	-0.3	-0.5	-0.7	-0.6	-0.9	0.4	-0.5
Diabetes diagnosed by doctor	2.1	3.5	5.8	0.9	1.9	2.2	2.4	1.9	-1.8	1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.3	-0.4	-1.1	-0.9	-1.0	-0.8	1.1	-0.6
Friendships satisfaction	0.2	0.2	0.4	0.6	0.5	0.5	-0.6	-0.4	0.2	0.1
Qualifications: nursing, teaching	1.5	2.3	4.1	1.6	1.5	2.0	1.1	1.6	-0.8	1.7
Commuting to job workplace: Walk	0.2	0.2	0.7	-0.3	-0.2	0.0	-0.8	-0.4	0.2	-0.8
Eye problems/disorders: Cataract	1.4	1.6	2.8	-1.7	-1.0	-0.7	-1.3	-1.7	0.8	-1.4
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.6	-0.9	-0.9	-0.6	-0.9	-0.8	1.3	-0.8
Medication for cholesterol	0.3	0.5	1.2	1.0	1.1	0.4	0.4	0.8	-0.2	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	4.2	-0.7	-1.3	-2.1	-0.2	-0.6	0.8	-0.8
Back pain experienced in last month	0.5	0.7	2.6	-0.5	-0.7	-0.6	1.6	0.7	-0.9	-0.1
Mineral and other dietary supplements	1.4	1.8	5.3	2.0	1.3	-0.1	0.4	1.1	-0.9	2.3
Breast cancer (self-reported)	0.2	0.3	0.6	0.3	0.6	0.8	0.4	0.8	0.1	0.1
Asthma (self-reported)	12.4	24.6	31.4	-4.6	-3.7	-5.6	-5.5	-5.5	4.8	-4.8
Osteoporosis (self-reported)	1.9	2.4	5.0	-2.2	-1.1	-1.0	-0.9	-1.6	1.3	-2.1
Osteoarthritis (self-reported)	8.1	10.5	12.5	-2.8	-3.5	-3.2	-3.0	-3.5	3.3	-3.4
Medication: Aspirin	0.4	0.5	1.5	-0.2	-1.2	-0.9	0.6	-0.7	0.3	-0.0
Medication: Gliclazide	0.3	0.4	1.2	0.3	0.3	1.1	0.7	0.6	-0.6	0.2
Illnesses of father: None of the above (group 1)	1.2	1.5	2.4	1.6	0.4	0.9	1.4	1.5	-1.1	1.4
Smoking status: Current	0.2	0.3	0.8	0.4	-0.9	-0.5	0.2	0.5	-0.2	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	6.0	12.7	29.1	3.6	2.8	5.4	3.2	3.7	-2.5	3.1
Whole body water mass	7.1	40.3	63.4	8.0	1.7	6.8	6.2	5.6	-6.6	7.5
Leg predicted mass (right)	4.0	21.2	35.7	6.0	0.6	4.2	4.5	3.9	-5.3	5.6
Arm fat mass (left)	0.7	2.9	6.9	2.0	-1.3	-1.5	1.2	0.4	-2.6	2.0
Number of self-reported non-cancer illnesses	3.2	5.6	15.1	-1.9	-2.2	-3.9	-1.5	-2.4	2.0	-1.7
Average weekly champagne plus white wine intake	0.4	0.6	1.4	-1.2	0.1	-0.8	-0.3	-0.4	0.6	-1.1
Miserableness	0.5	0.9	1.7	1.0	0.3	0.8	1.1	1.3	-0.2	1.1
Guilty feelings	0.2	0.3	0.8	0.6	0.9	-0.0	-0.1	0.5	0.2	0.6
Wears glasses or contact lenses	0.3	0.3	0.9	-0.3	-0.2	-0.6	0.9	0.9	-0.2	0.1
Ever taken oral contraceptive pill	1.8	2.0	3.3	0.4	1.5	1.6	1.7	1.8	-1.4	0.9
Hearing aid user	0.6	0.7	2.1	-1.1	-0.1	-1.4	-0.8	-0.4	-0.5	-0.7
Mother’s age at death	0.3	0.4	1.4	0.1	0.7	0.3	-0.2	0.8	-1.2	-0.0
Financial situation satisfaction	1.5	1.8	4.4	2.1	1.6	0.6	0.1	0.8	-1.2	1.9
Tinnitus: Yes, now most or all of the time	3.8	4.4	7.7	1.4	1.1	2.8	2.6	2.3	-2.2	1.7
Commuting to job workplace: Public transport	1.4	1.6	2.8	1.3	1.0	1.7	1.2	1.2	-0.6	1.6
Eye problems/disorders: Glaucoma	0.5	0.6	1.5	-1.2	-0.3	-0.4	1.2	0.0	0.1	-0.9
Medication: Blood pressure	0.2	0.4	1.3	-0.8	-0.8	-1.2	0.2	-0.6	0.3	0.0
Pain type(s) experienced in last month: Hip pain	1.6	2.1	4.9	-1.2	-2.2	-1.9	-0.5	-1.3	0.9	-1.3
Supplements: Fish oil (including cod liver oil)	1.6	2.0	4.5	-1.7	-1.1	-0.8	-1.2	-1.6	1.1	-2.1
High cholesterol (Self-reported)	3.1	5.4	12.4	-1.4	-2.5	-3.5	-2.4	-2.5	1.7	-1.6
Medication: Bendroflumethiazide	1.3	2.0	4.4	-1.8	-0.8	-2.1	-1.2	-1.3	1.1	-1.3
Medication: Paracetamol	2.3	3.5	5.5	-1.9	-2.0	-2.3	-0.9	-2.1	1.6	-1.9
Medication: Lisinopril	1.7	2.1	4.9	-2.2	-0.8	-1.6	-1.1	-1.3	1.3	-1.5
Medication: Atorvastatin	1.0	1.3	2.4	-1.4	-0.9	-1.6	-1.0	-1.3	0.6	-0.9
Illnesses of father: High blood pressure	0.6	0.7	2.2	0.5	1.5	0.9	0.1	0.5	-1.0	0.5
Alcohol drinker status: Never	0.9	1.1	2.4	0.4	1.3	1.5	0.6	0.8	-1.4	0.5
Ever smoked	1.2	2.1	5.4	1.6	1.4	0.2	-1.1	0.8	-2.3	1.7
Basal metabolic rate	6.2	34.5	55.4	7.4	1.2	5.7	5.9	5.1	-6.4	7.0
Leg fat percentage (left)	1.2	4.4	19.1	-0.7	-2.3	-4.4	-1.1	-2.0	-0.6	-0.3
Arm fat-free mass (left)	6.8	34.7	59.3	7.7	1.1	6.1	5.8	5.0	-6.0	7.1
Number of operations (self-reported)	2.2	3.3	6.2	2.3	0.8	2.1	1.5	1.7	-1.3	2.5
Average weekly beer plus cider intake	0.5	0.7	1.3	0.5	0.6	1.0	1.1	1.1	-0.3	0.7
Irritability	2.4	4.0	8.6	-1.6	-2.9	-1.8	-1.0	-1.6	2.7	-1.6
Risk taking	2.0	2.9	7.0	2.6	0.9	0.5	0.1	1.4	-1.9	2.6
Ever had prostate specific antigen (PSA) test	2.5	2.9	4.4	-1.2	-1.8	-1.4	-1.7	-1.8	2.1	-1.8
Fractured/broken bones in last 5 years	0.5	0.6	2.4	0.2	1.0	-0.5	-0.2	0.6	-1.6	0.4
Age started oral contraceptive pill	0.4	0.5	1.3	-0.8	0.1	-0.9	-0.6	-0.8	0.0	-1.1
Diastolic blood pressure, automated reading	4.0	12.3	17.9	-4.1	-2.6	-4.2	-2.8	-3.7	2.9	-3.9
Ever depressed for a whole week	1.4	1.7	4.1	0.8	2.0	1.5	1.6	1.2	-0.8	0.6
Unable to work because of sickness or disability	0.6	0.7	2.4	-0.4	-0.9	-1.6	-0.4	-1.2	0.0	-0.4
Commuting to job workplace: Cycle	1.3	1.5	4.5	0.5	1.4	2.1	1.6	1.3	0.0	0.4
Myopia	0.5	0.8	2.3	-1.1	0.1	-0.5	-1.5	-0.4	0.9	-0.7
Vascular/heart problems diagnosed by doctor	1.1	2.9	7.7	2.1	1.5	2.8	0.1	1.5	-1.4	1.3
Cholesterol lowering medication	3.1	4.6	7.5	-2.0	-2.2	-2.3	-2.7	-2.6	1.0	-1.6
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	3.7	-1.0	-1.9	-1.9	-0.1	-0.9	0.6	-0.6
Pain experienced in last month	0.6	1.1	2.9	0.9	1.7	1.6	-0.3	0.6	-0.9	0.5
Supplements: Calcium	0.6	0.7	1.7	-0.5	0.7	1.2	1.3	0.5	-0.7	-0.5
Basal cell carcinoma (self-reported)	3.8	4.5	5.9	1.8	2.0	2.4	2.4	2.1	-2.3	1.8
Heart attack/myocardial infarction (self-reported)	1.3	1.6	4.7	-0.8	-2.2	-1.9	0.3	-1.2	0.7	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.0	-0.8	-1.0	-0.3	0.6	-0.7	-0.1	-0.9
Heart disease (siblings)	1.9	2.3	4.8	-1.7	-2.2	-1.3	-0.5	-1.5	1.3	-1.6
Alcohol drinker status: Previous	0.4	0.5	1.6	-0.5	-0.8	-1.2	-0.4	-0.6	-0.1	-0.6
Pack years of smoking	0.3	0.4	1.5	0.2	-0.7	-1.2	-0.3	-0.7	0.5	0.3
Impedance of whole body	0.5	2.4	7.4	-2.7	0.1	-1.1	-1.1	-0.4	0.3	-2.6
Leg fat mass (left)	0.7	2.9	6.2	1.9	-1.5	-1.5	1.3	0.2	-2.5	2.0
Arm predicted mass (left)	6.7	34.2	57.8	7.6	1.1	6.0	5.8	5.0	-6.0	7.1