TWAS hub - DEF6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1360	0.0510	4.8e-04	0.035	NA	0.036	NA	0.032	1.2e-03	NA	9.7e-04	NA	1.7e-03
2	GTEx	Nerve Tibial	0.1472	0.0522	4.2e-04	-0.003	NA	0.002	NA	0.004	7.3e-01	NA	2.4e-01	NA	1.6e-01
3	GTEx	Whole Blood	0.1370	0.0560	3.1e-04	0.049	NA	0.020	NA	0.029	2.6e-05	NA	5.4e-03	NA	9.9e-04
4	NTR	Blood	0.0265	0.0104	1.1e-05	0.021	0.018	0.015	0.019	0.018	1.5e-07	9.3e-07	6.8e-06	7.2e-07	1.5e-06
5	ROSMAP	Brain Pre-frontal Cortex	0.0361	0.0171	1.2e-03	0.019	0.017	0.016	0.018	0.018	1.4e-03	2.7e-03	3.3e-03	1.8e-03	2.2e-03
6	TCGA	Brain Lower Grade Glioma	0.0372	0.0198	5.3e-04	0.011	0.025	0.020	NA	0.015	1.9e-02	6.2e-04	1.9e-03	NA	6.1e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Forced expiratory volume in 1-second (FEV1), predicted	12.9	26.8	42.6	0.4	6.5	6.5	3.6	6.4	4.7
Forced expiratory volume in 1-second (FEV1), Best measure	12.2	38.8	71.2	2.4	7.6	6.7	4.0	8.4	6.1
Respiratory disease	11.3	25.0	35.7	-2.7	-5.4	-4.6	-5.4	-6.0	-5.4
Forced expiratory volume in 1-second (FEV1)	11.1	37.3	68.6	2.5	7.4	6.6	4.0	8.3	5.9
Asthma (self-reported)	9.4	18.7	27.4	-2.6	-4.5	-4.1	-4.3	-5.2	-4.7
Lung FEV1/FVC ratio	8.6	43.5	71.6	1.9	7.0	7.0	6.1	8.5	7.1
Asthma	8.5	16.8	26.1	-2.3	-4.3	-3.9	-4.1	-5.1	-4.3
Lupus	7.5	11.3	18.1	-2.4	-2.5	-4.3	-3.4	-3.7	-3.5
Forced vital capacity (FVC), Best measure	6.9	25.4	46.6	1.9	6.5	5.6	2.5	6.8	4.6
Blood White Count	6.4	47.4	73.8	4.1	5.8	6.6	8.6	7.0	8.2
Forced vital capacity (FVC)	6.4	24.5	44.9	1.8	6.4	5.5	2.9	6.7	4.3
Trunk fat-free mass	6.3	36.0	76.7	-2.1	8.8	6.6	0.1	8.6	4.1
Trunk predicted mass	6.2	35.5	75.0	-2.0	8.7	6.6	0.1	8.6	4.1
Heel bone mineral density (BMD) T-score, automated (right)	6.1	14.1	23.6	2.6	2.4	4.3	3.5	4.2	4.9
Standing height	6.0	60.0	121.0	-2.7	11.0	9.4	2.7	10.7	4.6
Allergy	5.9	13.6	23.1	2.0	4.1	3.7	3.2	4.8	3.7
Wheeze or whistling in the chest in last year	5.9	10.5	17.2	-2.7	-3.2	-2.5	-2.9	-4.1	-3.6
Height	5.8	111.6	231.0	-3.8	15.2	13.5	4.2	13.6	6.2
Serious illness, injury or assault of a close relative in last 2 years	5.8	6.6	10.4	3.2	2.3	2.8	1.1	3.0	2.4
Peak expiratory flow (PEF)	5.7	13.2	25.1	2.7	3.2	3.8	3.1	5.0	3.6
Osteoarthritis (self-reported)	5.7	7.4	15.4	-1.0	-2.3	-3.9	-2.2	-2.7	-3.3
Arm predicted mass (right)	5.3	27.3	57.9	-3.4	7.6	5.6	-0.4	7.3	3.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	5.3	11.1	17.9	3.1	3.4	3.4	2.1	4.2	3.4
Hypothyroidism/myxoedema (self-reported)	5.2	10.1	16.2	-0.8	2.0	4.0	3.6	3.8	3.6
Whole body fat-free mass	5.2	29.4	64.5	-3.4	8.0	5.9	-0.5	7.5	3.0
Comparative height size at age 10	5.1	27.9	64.2	-2.8	8.0	6.4	1.9	6.5	2.9
Whole body water mass	5.1	29.4	65.1	-3.4	8.1	5.8	-0.4	7.5	3.0
Heel bone mineral density (BMD) T-score, automated (left)	5.0	11.3	20.3	2.0	2.2	3.9	3.6	3.2	4.5
Arm fat-free mass (right)	5.0	25.5	55.8	-3.5	7.5	5.3	-0.6	7.0	2.7
Basal metabolic rate	4.9	27.0	58.7	-4.3	7.7	5.5	-0.5	6.9	2.4
Had major operations	4.7	5.5	10.1	2.3	2.8	1.6	1.2	3.2	2.4
Arm fat-free mass (left)	4.7	24.1	51.8	-3.5	7.2	5.0	-0.9	6.9	2.6
Arm predicted mass (left)	4.7	23.9	52.9	-3.5	7.3	5.1	-0.7	6.7	2.6
Medication: Seretide 50 evohaler	4.5	5.2	9.1	-1.8	-2.4	-1.2	-1.7	-3.0	-2.9
Sensitivity / hurt feelings	4.3	7.4	11.6	2.0	1.7	3.2	3.3	2.2	3.4
Leg predicted mass (left)	4.2	22.1	47.4	-4.7	6.9	4.8	-0.7	6.0	1.7
Birth weight	4.2	9.2	19.2	0.4	3.5	4.4	2.2	2.6	3.4
Hand grip strength (left)	4.1	10.8	20.5	2.3	2.9	4.3	1.6	4.5	3.0
Leg fat-free mass (left)	4.1	21.7	46.9	-4.7	6.8	4.7	-0.7	5.9	1.6
Alzheimer’s Disease (in mother)	3.9	4.6	7.0	2.6	0.4	2.2	2.2	2.0	2.6
Allergy or Eczema	3.9	10.4	20.2	-1.2	-4.5	-3.2	-2.2	-4.2	-2.8
Medication: Levothyroxine sodium	3.9	6.6	10.7	-0.6	1.6	3.0	3.3	2.9	3.0
Birth weight of first child	3.8	6.9	10.9	1.2	2.9	2.9	1.6	3.1	3.3
Leg fat-free mass (right)	3.8	20.1	43.8	-4.7	6.6	4.5	-0.9	5.6	1.4
Cholesterol lowering medication	3.8	5.6	8.1	-0.9	-1.8	-2.7	-2.8	-2.4	-2.8
Illness, injury, bereavement, stress in last 2 years	3.7	4.5	6.2	-1.6	-2.5	-2.4	-1.4	-2.4	-2.1
Leg predicted mass (right)	3.7	19.6	42.5	-4.7	6.5	4.4	-1.0	5.5	1.3
Alzheimer’s Disease (including proxy)	3.6	5.3	9.9	3.1	0.6	2.0	2.1	2.2	2.9
Weight	3.6	17.9	41.3	-6.4	5.7	3.8	-1.1	4.2	0.3
Medication: Ventolin 100micrograms inhaler	3.6	4.6	6.7	0.2	-2.5	-2.2	-2.6	-2.3	-2.2
Chronic bronchitis/emphysema (mother)	3.6	4.2	8.4	-0.9	-1.7	-1.5	-2.9	-2.2	-2.4
Leg fat percentage (left)	3.6	13.0	52.1	-7.2	-0.1	-1.5	-2.6	-2.1	-3.6
Ever had hysterectomy (womb removed)	3.3	3.7	6.0	-0.3	-2.1	-2.2	-2.3	-1.1	-2.5
Trunk fat percentage	3.3	13.4	66.4	-8.2	0.9	-0.1	-1.2	-1.2	-3.2
Type 2 Diabetes (T2D) (2012)	3.2	3.7	9.6	0.2	-3.1	-1.3	-1.8	-2.1	-1.7
Trunk fat mass	3.2	13.8	64.2	-8.0	3.0	1.6	-1.2	1.1	-2.0
Fluid intelligence score	3.2	6.5	9.2	1.5	2.7	2.8	1.9	3.0	3.0
Body fat percentage	3.2	12.7	60.1	-7.8	0.5	-0.5	-1.6	-1.6	-3.3
Number of self-reported non-cancer illnesses	3.2	5.5	7.7	-2.0	-2.8	-2.5	-2.1	-2.5	-2.0
Medication: Paracetamol	3.2	5.0	8.7	-1.2	-2.9	-2.7	-1.4	-2.5	-2.2
Diastolic blood pressure, automated reading	3.2	9.9	20.0	-0.4	-3.2	-3.4	-2.2	-4.5	-3.6
Diabetes (mother)	3.1	3.9	9.2	0.7	2.3	1.5	1.2	3.0	2.1
Hand grip strength (right)	3.1	8.4	16.6	2.1	2.1	4.0	1.3	4.1	2.7
Arm fat percentage (left)	3.1	12.2	51.0	-7.1	0.1	-1.1	-2.1	-2.1	-3.5
High cholesterol (Self-reported)	3.1	5.6	7.3	-2.1	-2.7	-2.6	-2.3	-2.1	-2.2
Hip circumference	3.0	13.0	32.5	-5.7	4.8	2.7	-1.2	3.6	-0.3
Hayfever, allergic rhinitis or eczema	2.9	6.3	11.4	-1.0	-3.1	-2.6	-1.9	-3.4	-2.3
Arm fat percentage (right)	2.9	11.4	46.0	-6.8	-0.2	-1.1	-2.2	-2.1	-3.4
Whole body fat mass	2.9	12.2	56.0	-7.5	3.0	1.5	-1.4	1.1	-1.7
LDL Cholesterol	2.8	4.4	8.1	-1.0	-1.6	-2.8	-2.3	-2.8	-1.4
Hypothyroidism (self reported)	2.8	6.5	11.5	-1.6	1.0	3.0	3.4	2.7	2.7
Leg fat mass (left)	2.8	10.9	49.7	-7.0	2.6	0.9	-2.0	0.8	-1.8
Systolic blood pressure, automated reading	2.7	7.8	20.9	0.8	-2.6	-3.2	-0.4	-4.6	-2.8
Leg fat percentage (right)	2.7	9.9	45.0	-6.7	0.4	-0.8	-1.9	-1.4	-2.8
Leg fat mass (right)	2.7	10.5	47.3	-6.9	2.9	1.2	-1.6	1.1	-1.5
Commuting to job workplace: Cycle	2.7	3.3	11.3	3.4	0.0	1.1	1.5	1.5	1.7
Heel T-Score	2.6	20.4	31.2	4.8	2.3	3.4	4.5	5.6	5.6
Health satisfaction	2.6	3.4	5.8	-0.7	-2.0	-2.0	-2.1	-1.3	-2.4
Medication for pain relief, constipation, heartburn	2.6	4.5	9.7	1.5	3.1	1.9	1.6	2.5	1.7
Illnesses of father: Heart disease	2.6	3.6	7.8	-1.0	-1.5	-2.0	-0.8	-2.8	-2.4
Arm fat mass (left)	2.6	10.6	47.5	-6.9	2.9	1.2	-1.6	0.9	-1.7
Tinnitus: Yes, now most or all of the time	2.6	3.0	5.7	0.2	1.9	2.4	1.1	2.2	1.7
Severe depression (siblings)	2.5	2.8	4.2	0.0	1.8	1.7	2.0	1.7	2.1
Alcohol intake versus 10 years previously	2.5	3.8	9.9	0.4	1.2	1.6	3.1	1.7	2.3
Arm fat mass (right)	2.5	10.4	48.0	-6.9	2.5	1.0	-1.8	0.5	-1.9
Mean Putamen Volume	2.4	2.8	6.3	0.4	2.5	1.9	1.6	1.4	1.5
Primary Biliary Cirrhosis	2.4	3.4	7.1	-2.7	-1.2	-0.6	-1.9	-2.2	-1.8
Lung FVC	2.4	12.3	18.5	3.5	4.1	2.1	2.7	3.8	4.3
Number of operations (self-reported)	2.4	3.6	8.3	1.4	2.8	0.5	0.2	2.9	1.9
Pulse rate, automated reading	2.3	7.3	15.4	1.1	-3.9	-2.5	-1.4	-3.8	-2.2
Heart attack	2.2	2.8	6.0	-2.4	-0.9	-2.4	-0.4	-1.4	-1.4
Medication: Atorvastatin	2.2	2.7	7.1	-1.1	-1.3	-2.7	-0.8	-1.9	-1.4
Verbal and Numeric Reasoning (VNR)	2.1	5.2	8.2	2.4	1.9	2.5	0.6	2.9	2.7
Waist circumference	2.1	7.8	34.8	-5.9	2.7	1.0	-1.4	0.9	-1.0
Qualifications: None of the above	2.1	4.6	8.2	-2.6	-1.5	-2.2	-0.8	-2.9	-2.3
Qualifications: O levels/GCSEs or equivalent	2.1	3.3	4.2	2.1	1.5	1.5	1.9	1.9	2.0
Heart attack/myocardial infarction (self-reported)	2.1	2.7	6.5	-2.5	-0.8	-2.3	-0.4	-1.3	-1.4
Ever used hormone-replacement therapy (HRT)	2.0	2.6	5.6	0.1	-2.4	-1.7	-1.6	-1.3	-1.7
Prospective memory result	2.0	2.4	9.1	-1.2	-1.1	-1.3	0.1	-3.0	-1.1
Systolic Blood Pressure	1.9	9.7	22.3	2.3	-3.5	-3.5	0.5	-4.7	-2.3
Number of treatments/medications taken	1.9	3.4	5.3	-1.1	-2.3	-2.0	-1.3	-2.2	-1.9
Supplements: Glucosamine	1.9	2.5	7.1	-0.1	-1.1	-1.1	-2.7	-1.1	-2.0
Medication: Simvastatin	1.9	2.8	5.5	-0.9	-2.3	-1.4	-1.4	-2.0	-1.6
Hair/balding pattern: Pattern 4	1.9	4.5	8.6	1.9	1.1	0.6	2.9	2.5	2.6
Knee pain experienced in last month	1.9	3.0	6.7	-0.1	-2.6	-1.2	-1.5	-1.6	-2.2
Commuting to job workplace: Public transport	1.9	2.3	4.2	2.0	1.0	1.0	1.3	1.9	1.6
Time employed in main current job	1.8	2.1	3.9	-1.9	-1.3	-1.0	-0.1	-2.0	-1.3
Falls in the last year	1.8	2.5	7.3	-2.7	0.5	-1.6	-1.1	-0.3	-1.9
Medication: Paracetamol	1.8	3.0	6.0	-1.1	-2.4	-2.1	-1.1	-1.9	-1.3
Supplements: Fish oil (including cod liver oil)	1.8	2.3	4.7	-0.1	-1.3	-1.5	-2.2	-1.4	-1.7
Blood Eosinophil Count	1.7	13.1	28.4	-2.5	-4.4	-2.0	3.4	-5.3	-3.1
Sitting height	1.7	12.2	28.7	-4.1	5.4	3.2	0.4	4.0	0.9
Had menopause	1.7	2.2	3.5	-0.9	-1.9	-1.6	-0.9	-1.6	-1.7
Exposure to tobacco smoke at home	1.7	1.9	5.3	-2.3	0.5	-1.1	-2.0	0.3	-0.4
Illnesses of siblings: Diabetes	1.7	2.1	3.0	1.7	0.8	1.2	1.6	1.7	1.5
Qualifications: nursing, teaching	1.7	2.6	6.2	1.6	0.7	1.6	0.8	2.5	1.8
Eye problems/disorders: Cataract	1.7	1.9	3.5	-0.9	-1.0	-1.5	-1.6	-1.3	-1.9
Osteoporosis (self-reported)	1.7	2.0	3.6	0.9	-1.4	-1.9	-1.3	-1.2	-1.8
Basal cell carcinoma (self-reported)	1.7	2.0	4.4	-0.4	1.4	1.4	1.4	2.1	1.4
Body mass index (BMI)	1.6	6.6	29.8	-5.5	1.0	-0.3	-2.3	-0.5	-1.8
Medication: Blood pressure	1.6	2.9	6.7	-1.0	-2.6	-1.9	-0.1	-2.4	-0.5
Age at last live birth	1.6	2.3	4.7	2.2	0.3	0.5	1.8	1.4	1.9
Heart disease (siblings)	1.6	2.0	5.1	0.9	-2.3	-1.6	-1.2	-0.8	-1.2
Triglycerides	1.5	2.4	7.1	-2.1	-0.2	-0.6	-2.7	-0.9	-1.3
Chronotype (morning person)	1.5	3.4	9.6	-0.8	3.1	0.6	2.5	1.5	1.0
Average weekly spirits intake	1.5	1.9	4.1	-1.9	-1.2	-0.3	-1.2	-2.0	-0.9
Average weekly fortified wine intake	1.5	1.8	3.0	-0.8	-1.1	-1.2	-1.7	-1.6	-1.5
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	5.4	0.7	1.4	0.2	2.3	1.3	1.1
Emphysema/chronic bronchitis	1.5	1.7	5.5	-2.4	-0.9	-0.9	-0.1	-1.0	-1.5
Ever taken oral contraceptive pill	1.5	1.6	3.5	0.2	1.1	1.5	1.9	0.6	1.6
Alzheimer’s Disease (in father)	1.4	1.5	2.6	1.6	0.9	1.0	0.9	1.4	1.3
Ulcerative Colitis (UC)	1.4	2.5	6.1	2.5	-2.5	0.4	1.3	-0.9	0.5
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	3.3	1.8	1.4	0.9	-0.5	1.5	1.2
Pulse rate	1.4	2.4	6.2	-0.1	-1.8	-1.5	-0.8	-2.5	-1.3
Overall health rating	1.4	2.9	4.1	-1.3	-1.6	-1.6	-2.0	-1.6	-2.0
Illnesses of father: None of the above (group 1)	1.4	1.8	4.8	-0.5	0.9	1.4	0.8	2.2	1.4
Miserableness	1.4	2.4	4.5	1.6	1.1	1.9	1.0	1.4	2.1
Pain type(s) experienced in last month: Hip pain	1.4	1.7	2.9	-1.1	-1.4	-1.4	-0.8	-1.2	-1.7
HDL Cholesterol	1.3	2.2	3.8	0.8	-1.3	-1.8	-1.8	-1.9	-0.8
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	5.1	2.3	-0.7	0.3	1.4	0.8	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	4.0	0.9	1.6	1.0	1.4	1.1	2.0
Pulse wave reflection index	1.3	1.6	4.3	-0.4	2.1	1.8	0.3	1.1	0.8
Shortness of breath walking on level ground	1.3	1.5	6.1	-2.5	0.4	-0.9	-0.4	-0.5	-1.2
Heart disease (mother)	1.3	1.6	2.9	0.5	-1.7	-1.2	-1.4	-1.3	-1.1
Ever had prostate specific antigen (PSA) test	1.3	1.4	4.5	0.4	-1.0	-0.9	-2.1	-0.6	-1.3
Age at First Birth	1.2	1.8	8.0	2.8	-0.8	-0.0	1.0	0.2	0.9
HbA1C	1.2	1.3	2.8	-0.3	0.8	1.7	1.5	0.8	1.1
Cardiovascular Disease	1.2	3.8	7.3	-1.2	-2.7	-1.7	-1.2	-2.6	-1.7
Qualifications: CSEs or equivalent	1.2	1.5	6.2	-2.5	1.2	0.3	-0.6	-1.0	-0.5
Illnesses of siblings	1.2	1.8	4.6	-1.4	2.1	1.4	0.7	0.9	0.9
Worrier / anxious feelings	1.2	2.3	6.0	0.6	-2.3	0.9	2.5	-0.7	0.9
Medication: Cholesterol lowering	1.2	1.8	3.4	-1.8	-1.6	-1.1	-0.8	-1.6	-0.8
Depression (self-reported)	1.2	1.5	3.9	0.2	0.7	0.8	2.0	0.9	1.7
High blood pressure (siblings)	1.2	1.7	4.9	0.4	-2.2	-1.6	-0.6	-1.1	-1.0
Worry too long after embarrassment	1.2	2.0	5.9	1.2	-1.0	0.9	2.4	0.5	1.5
Eye problems/disorders: None of the above	1.2	1.3	2.8	0.5	1.7	1.0	0.7	1.0	1.6
Mineral and other dietary supplements	1.2	1.6	4.6	-0.6	1.3	0.3	2.1	0.5	1.6
Medication: Bendroflumethiazide	1.2	1.8	6.0	0.1	-2.5	-0.8	-0.3	-1.7	-0.9
Medication: Lisinopril	1.2	1.6	2.9	-0.2	-1.7	-1.3	-1.0	-1.6	-1.1
Ever depressed for a whole week	1.2	1.4	3.5	1.3	0.5	0.4	1.9	1.2	1.3
Schizophrenia (2018)	1.1	2.3	5.1	2.1	0.8	1.5	0.5	2.2	1.0
BMI	1.1	6.6	29.7	-5.5	2.0	-0.2	-2.1	-0.1	-1.3
Angina	1.1	1.5	4.5	-0.9	-1.1	-2.1	0.4	-1.0	-1.0
Number of live births	1.1	1.6	3.9	-2.0	-0.5	-1.4	-1.1	-1.1	-0.8
Lung cancer (father)	1.1	1.3	3.3	-0.6	-0.5	0.7	1.8	1.7	0.6
Angina (self-reported)	1.1	1.4	4.2	-0.9	-1.2	-2.1	0.2	-1.0	-1.0
Smoking status: Previous	1.1	1.7	2.5	-1.1	-0.6	-1.5	-1.2	-1.6	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.1	3.5	0.8	-1.3	-0.8	-1.9	-0.5	-0.3
Body Mass Index (BMI) (2010)	1.0	1.4	4.6	-2.1	0.4	-1.3	-1.0	0.0	-0.8
Hearing difficulty/problems: Yes	1.0	1.5	3.3	0.4	1.1	1.8	1.6	1.0	0.9
Hair/balding pattern: Pattern 2	1.0	1.2	2.4	-0.3	-1.5	-0.5	-1.5	-1.2	-0.9
Number of full sisters	1.0	1.2	3.7	-0.7	1.9	1.3	0.3	0.8	0.7
Average weekly beer plus cider intake	1.0	1.5	2.8	1.7	0.8	1.5	-0.1	1.5	1.0
Irritability	1.0	1.6	5.8	0.4	-2.4	0.0	-1.5	-1.3	-0.2
Age started oral contraceptive pill	1.0	1.3	2.3	-0.9	-1.1	-1.4	-0.2	-1.2	-1.5
Worry (Nagel 2018)	0.9	2.0	4.4	2.1	-2.0	0.2	0.9	-1.6	0.4
Ulcerative Colitis	0.9	1.3	4.3	1.2	-2.1	0.2	-0.1	-1.4	-0.2
Frequency of depressed mood in last 2 weeks	0.9	1.3	3.7	1.9	0.3	0.9	0.5	0.8	1.4
Vitamin and mineral supplements	0.9	1.2	2.4	-0.2	1.5	0.7	1.6	1.0	0.9
Supplements: Zinc	0.9	0.9	1.7	0.9	0.4	1.3	-1.3	1.2	0.2
Pain all over the body in last month	0.9	1.0	2.1	1.1	0.6	1.4	0.1	0.7	1.4
Age at first live birth	0.9	1.5	6.4	2.5	-1.2	-0.3	0.9	0.3	0.7
Qualifications: College or University degree	0.9	2.8	4.2	1.8	1.1	2.0	1.3	2.0	1.6
Chest pain or discomfort	0.9	1.3	2.7	-0.4	-1.1	-1.4	-1.6	-0.2	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.0	-0.3	-0.9	-1.0	-1.4	-0.8	-1.4
Hypertension (Self-reported)	0.9	2.5	5.7	0.2	-2.4	-1.8	-1.1	-2.0	-0.9
Breast cancer (self-reported)	0.9	1.1	3.2	1.8	-0.1	1.1	0.4	1.0	1.1
Wears glasses or contact lenses	0.9	1.0	2.4	0.7	0.2	1.5	1.5	0.2	1.0
Hearing aid user	0.9	1.0	2.4	-1.5	0.6	0.6	-1.1	-0.9	-1.0
Risk taking	0.9	1.3	3.2	-0.6	1.8	0.3	-0.2	1.6	1.3
Unable to work because of sickness or disability	0.9	1.1	1.9	-0.6	-0.8	-0.7	-1.4	-1.3	-1.3
Vascular/heart problems diagnosed by doctor	0.9	2.4	5.6	0.3	2.4	1.9	0.5	1.9	1.0
Medication: Omeprazole (e.g. Zanprol)	0.9	1.0	2.8	-1.7	-0.6	-0.5	-0.6	-1.2	-1.1
Intelligence (Savage-Jansen 2018)	0.8	2.4	4.0	1.9	0.9	1.5	0.2	2.0	2.0
Neuroticism (Nagel 2018)	0.8	1.9	3.3	1.8	-1.6	0.7	1.8	-0.8	1.2
Irritable Bowel Disease (IBD)	0.8	1.9	4.4	2.1	-1.5	0.6	1.6	-0.1	1.3
Blood Platelet Count	0.8	9.6	23.4	4.7	-2.0	1.2	4.8	-0.7	2.5
Medication: Co-codamol	0.8	0.9	1.8	-1.3	0.7	-0.5	-1.2	0.6	-1.0
Past tobacco smoking	0.8	1.5	2.6	1.6	0.0	1.2	1.4	1.1	1.4
Medication: Ramipril	0.8	1.1	3.2	0.0	-1.2	-1.8	-0.9	-0.9	-0.3
Neuroticism score	0.8	1.7	3.8	1.3	-0.0	1.6	1.5	0.3	1.9
Qualifications: A levels/AS levels or equivalent	0.8	1.7	6.1	2.5	-0.7	0.5	1.1	1.2	0.8
Pulse wave Arterial Stiffness index	0.8	1.0	2.2	-1.5	1.5	1.1	-0.2	0.4	-0.1
Breastfed as a baby	0.8	1.0	2.2	-1.2	-0.6	-0.2	-0.1	-1.4	-1.5
Medication: Allopurinol	0.8	1.1	2.7	0.2	-1.6	-0.9	-1.0	-1.3	-0.6
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.3	1.5	-0.8	0.1	-0.3	-1.5	-0.7
Ever had bowel cancer screening	0.8	0.9	1.8	-0.9	0.1	-1.2	-1.4	-0.7	-0.9
Diabetes diagnosed by doctor	0.8	1.3	2.8	0.7	0.8	0.9	1.7	0.6	1.6
Supplements: Calcium	0.8	0.9	2.5	1.6	-0.1	0.6	-0.5	1.5	0.0
Breast Cancer	0.7	1.8	3.5	1.1	0.7	1.9	1.4	1.2	1.4
Fasting Glucose	0.7	0.9	2.7	-0.2	0.6	1.6	-0.9	0.7	0.9
Hair Pigment	0.7	19.6	34.5	2.6	3.7	3.7	5.9	4.5	5.3
Relative age of first facial hair	0.7	1.4	2.9	1.2	0.7	1.7	0.8	1.6	0.3
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.4	-1.6	-0.4	-0.8	-0.8	-0.5	-1.2
Diabetes (father)	0.7	0.9	3.9	-0.1	-0.7	-0.0	-0.4	-2.0	-0.8
Nervous feelings	0.7	1.4	3.1	1.0	-1.8	-1.1	0.2	-1.7	-0.1
Hair/balding pattern: Pattern 3	0.7	1.0	3.0	0.6	1.7	0.5	1.0	0.9	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.8	-0.5	-1.7	-0.8	-0.3	-1.0	-0.7
Blood clot in the leg (DVT)	0.7	1.0	2.2	-1.1	-0.9	-0.6	-0.5	-1.0	-1.5
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	1.9	1.4	1.4	1.0	-0.4	1.4	0.0
Gout (self-reported)	0.7	0.9	2.3	0.1	-1.5	-0.7	-0.9	-1.4	-0.1
Neck or shoulder pain in last month	0.7	0.9	2.1	1.1	-0.3	1.1	-1.5	0.6	0.8
Medication: Ibuprofen	0.7	0.9	3.4	-0.3	-1.9	-0.6	-0.4	-0.9	-0.7
Average weekly red wine intake	0.7	1.1	2.5	-0.4	-0.4	-1.5	-0.3	-1.2	-1.6
Long-standing illness, disability or infirmity	0.7	1.1	1.5	-0.9	-1.1	-1.1	-1.0	-1.2	-0.7
Alcohol drinker status: Never	0.7	0.8	4.2	-0.1	0.3	2.1	0.3	0.5	0.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.9	-1.1	-0.9	-0.6	-0.5	-0.9	-1.4
Alcohol drinker status: Previous	0.7	0.7	1.8	-1.3	-0.4	-0.0	-0.7	-1.1	-0.9
Depression (Nagel 2018)	0.6	0.9	2.8	1.7	-1.1	0.8	0.3	-0.0	0.7
Schizophrenia vs Biploar Disorder	0.6	0.8	1.9	1.4	0.8	1.1	0.0	0.7	0.8
Medication for hormone replacement therapy	0.6	0.7	1.5	1.2	0.2	1.0	0.2	1.2	0.5
Maternal smoking around birth	0.6	0.8	3.1	-0.8	0.8	-0.6	-1.7	-0.1	-0.1
High blood pressure	0.6	1.7	5.6	0.8	-2.4	-1.4	-0.5	-1.4	-0.3
Medication: Atenolol	0.6	0.7	1.3	-1.1	-0.8	-1.0	-0.2	-1.1	-0.4
Number of incorrect matches in round	0.6	1.0	2.1	0.4	0.7	0.5	1.4	1.3	1.1
Impedance of arm (right)	0.6	2.9	6.2	-0.3	-2.1	-0.8	1.4	-2.5	-2.0
Happiness	0.6	0.8	1.6	1.3	0.3	0.7	0.9	1.0	0.8
Illnesses of mother	0.6	0.7	1.8	-0.2	1.1	0.8	1.3	0.4	-0.3
Impedance of arm (left)	0.6	2.8	5.3	-0.8	-2.0	-0.6	1.6	-2.3	-1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.7	1.3	-1.3	-0.5	-0.7	-0.5	0.2
Family relationship satisfaction	0.6	0.7	2.3	0.0	1.5	0.6	0.2	0.9	0.9
Eye problems/disorders: Glaucoma	0.6	0.7	2.0	0.8	-1.4	-0.2	0.9	-0.6	-0.3
Ever smoked	0.6	1.0	2.5	-1.6	1.5	-0.4	-0.7	0.8	-0.4
Major Depression (MDD)	0.5	0.6	1.4	-0.4	0.4	-0.6	-1.2	-0.8	-0.9
Bipolar Disorder (2011)	0.5	0.5	1.4	-1.2	-0.2	-0.3	0.4	0.4	-0.9
Crohns Disease (2012)	0.5	0.8	2.5	1.1	0.0	0.4	0.8	0.5	1.6
Smoking Status	0.5	1.2	3.6	-0.6	-0.9	-0.4	-1.9	-0.3	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.3	1.5	-0.7	1.1	0.0	-0.1	0.3
Multivitamins +/- minerals	0.5	0.6	2.1	-0.2	-0.6	-0.9	-1.4	-0.2	-0.4
High blood pressure (mother)	0.5	0.8	1.7	0.8	1.3	0.2	0.1	0.9	1.2
Had other major operations	0.5	0.6	1.5	-0.3	0.9	-0.6	1.2	1.0	0.1
Financial difficulties in last 2 years	0.5	0.7	1.7	-0.6	0.6	0.7	0.5	1.3	0.9
Comparative body size at age 10	0.5	1.3	3.1	-1.1	1.6	-1.0	-1.8	0.6	-0.1
Mouth/teeth dental problems: Loose teeth	0.5	0.5	1.2	-0.7	0.1	-0.8	-0.9	0.0	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.8	1.0	-0.3	1.4	-0.4	0.2	0.8
Medication for cholesterol	0.5	0.8	1.6	-1.3	0.8	1.0	1.0	0.4	0.7
Impedance of whole body	0.5	2.5	4.8	-0.1	-2.1	-0.6	2.2	-2.1	-1.2
Bipolar Disorder or Schizophrenia	0.4	1.0	3.1	1.0	0.9	0.6	0.5	1.8	0.5
Coronary Artery Disease (CAD)	0.4	0.5	1.2	-0.7	-1.1	-1.1	0.0	-0.5	-0.2
Rheumatoid Arthritis	0.4	0.6	2.1	-1.5	0.7	0.3	0.3	0.5	0.6
Waist Hip Ratio (WHR)	0.4	1.9	6.9	0.6	-1.6	-0.7	1.1	-2.6	-0.1
Neuroticism	0.4	0.9	1.6	1.0	-1.3	0.6	1.0	-1.1	0.7
Medication: Metformin	0.4	0.5	1.8	-0.7	0.4	0.2	0.3	0.7	1.3
Impedance of leg (right)	0.4	2.0	7.5	1.5	-1.0	0.6	2.7	-0.3	0.8
Relative age voice broke	0.4	0.6	1.4	0.7	0.8	0.6	1.0	1.2	0.3
Stomach or abdominal pain in last month	0.4	0.5	1.3	-1.1	0.5	-0.4	0.3	1.1	0.2
Hearing difficulty/problems with background noise	0.4	0.6	1.5	-0.1	1.2	1.1	0.9	0.3	0.1
Medication: Lansoprazole	0.4	0.5	2.2	-0.6	-0.1	-0.3	1.5	-0.4	-0.2
Medication: Amlodipine	0.4	0.6	2.2	-0.1	-1.5	-0.1	0.4	-1.0	0.3
Migraine (self-reported)	0.4	0.5	1.0	-0.9	0.1	-0.4	-0.9	-0.3	-1.0
Leg pain on walking	0.4	0.5	1.3	0.6	-1.0	0.1	-1.1	-0.2	-0.2
Medication: Aspirin	0.4	0.5	1.2	-1.1	-0.5	-1.0	-0.5	-0.1	-0.7
Average weekly champagne plus white wine intake	0.4	0.6	1.6	0.2	-0.8	-0.5	0.9	-1.2	-0.5
Guilty feelings	0.4	0.6	1.8	0.8	0.3	0.4	0.9	0.3	1.4
Financial situation satisfaction	0.4	0.6	2.0	-0.3	0.7	0.3	0.4	1.4	0.7
Pack years of smoking	0.4	0.7	1.8	-1.0	-0.6	-1.3	-0.5	-0.7	-0.2
Reaction Time	0.3	0.5	1.7	-0.7	-0.1	-0.6	-0.1	-1.3	-0.8
Ovarian Cancer	0.3	0.4	1.4	1.2	0.7	0.3	0.4	0.2	0.5
Neuroticism (2016)	0.3	0.4	1.3	1.2	-0.5	0.1	-0.0	-0.7	0.4
Schizophrenia (2014)	0.3	0.7	2.4	0.9	0.6	0.6	-0.1	1.6	0.3
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.4	0.7	-0.0	0.3	1.2	0.4	0.4
Townsend deprivation index at recruitment	0.3	0.4	0.8	-0.7	0.5	-0.5	-0.9	0.7	0.6
Fed-up feelings	0.3	0.5	1.5	-0.2	-0.3	0.4	1.0	-0.6	1.2
Age when periods started (menarche)	0.3	0.7	3.6	1.9	-0.3	0.4	0.3	0.3	0.2
Impedance of leg (left)	0.3	1.6	4.3	0.9	-1.7	-0.3	2.1	-1.3	-0.2
Father’s age at death	0.3	0.3	1.1	0.5	0.3	1.0	-0.2	0.4	0.6
Tense / ‘highly strung’	0.3	0.5	1.6	1.3	-0.5	0.3	0.6	-0.2	0.8
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.0	-0.2	-0.1	-0.2	1.0	0.8	0.7
Glaucoma (self-reported)	0.3	0.3	1.6	-0.1	-0.4	-0.1	1.2	-0.4	0.2
Number of full brothers	0.3	0.3	1.2	-0.3	0.1	0.2	0.6	0.5	1.1
Pulse wave peak to peak time	0.3	0.4	1.3	1.1	-0.7	-0.4	0.3	0.2	0.4
Medication: Omeprazole	0.3	0.3	1.1	-1.0	-0.6	0.0	-0.4	-0.4	-0.6
Mean time to correctly identify matches	0.3	0.6	1.4	-1.2	0.3	-0.8	-0.2	-0.9	-0.8
Suffer from ‘nerves’	0.3	0.5	1.2	1.1	-0.8	0.2	-0.3	-0.9	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.3	0.7	-1.1	0.0	0.3	-0.6	-0.1
Mood swings	0.3	0.6	1.5	0.6	-0.1	1.2	0.7	-0.3	1.2
Loneliness, isolation	0.3	0.4	1.6	-0.6	-0.2	-1.3	-0.1	-0.6	0.0
Friendships satisfaction	0.3	0.4	1.9	0.5	-0.1	-1.4	-0.1	-0.1	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.1	0.8	-1.0	-0.4	-1.0	-0.2	-0.4
Mother’s age at death	0.3	0.4	0.8	0.5	0.6	0.8	0.9	0.8	0.1
Fractured/broken bones in last 5 years	0.3	0.4	1.6	-1.3	0.2	0.3	0.2	0.3	-0.9
Bipolar Disorder (2018)	0.2	0.4	1.2	-1.1	0.4	-0.7	0.2	0.1	-0.4
Depressed Affect (Nagel 2018)	0.2	0.3	1.0	0.1	-0.5	0.1	1.0	-0.6	0.6
Crohns Disease (2017)	0.2	0.4	1.0	0.6	-0.6	-0.1	0.7	0.3	1.0
Blood Red Count	0.2	2.2	5.5	2.2	1.1	0.5	-0.2	1.2	2.3
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.1	0.2	0.5	0.1	1.0	0.4	1.1
Pack years adult smoking proportion	0.2	0.3	0.9	-0.8	0.0	-1.0	0.0	-0.0	0.2
Current tobacco smoking	0.2	0.3	0.9	-0.6	0.1	0.5	-0.4	0.9	0.4
Taking other prescription medications	0.2	0.3	0.8	-0.5	-0.6	-0.4	0.9	0.2	-0.1
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	0.1	-0.3	-0.7	-0.7	0.4	-0.5
Chronic bronchitis/emphysema (father)	0.2	0.2	0.5	0.4	-0.6	-0.3	0.7	0.3	0.5
Alcohol usually taken with meals	0.2	0.2	0.6	0.6	0.2	-0.2	0.8	-0.7	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.5	0.7	-0.7	-0.4	-0.7	-0.4	-0.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.7	0.3	0.0	0.3	0.9	0.2	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.8	0.4	0.1	0.9	0.4	0.5	0.6
Loud music exposure frequency	0.2	0.2	0.4	-0.6	-0.6	-0.4	0.3	-0.3	-0.6
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.7	-0.4	0.5	0.9	0.5	-0.1	-0.5
Headache pain in last month	0.2	0.4	2.1	0.5	-1.4	-0.3	0.2	-0.3	0.1
Exposure to tobacco smoke outside home	0.2	0.2	0.9	-0.9	0.4	0.2	-0.2	0.4	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.8	-0.4	0.2	0.9	-0.2	-0.4	-0.4
Alcohol intake frequency.	0.2	0.4	1.9	-1.4	0.2	0.5	-0.1	-0.5	0.3
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.6	-0.6	-0.4	-0.3	0.3	-0.8	-0.0
Medication: Aspirin	0.2	0.3	0.7	-0.7	-0.5	-0.8	-0.3	-0.1	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.9	-0.2	-0.6	-0.4	-0.4	-0.9	-0.4
Back pain experienced in last month	0.2	0.3	0.6	-0.8	-0.4	0.7	0.6	0.4	-0.3
Smoking status: Current	0.2	0.3	0.7	-0.5	0.3	0.7	-0.7	0.8	0.3
Medication: Blood pressure	0.2	0.5	1.0	0.7	-1.0	-1.0	-0.4	-0.4	-0.3
Illnesses of father: High blood pressure	0.2	0.3	0.7	0.3	0.4	-0.6	0.8	-0.4	0.2
Myopia	0.2	0.2	1.0	1.0	-0.0	0.1	-0.2	-0.4	0.4
Pain experienced in last month	0.2	0.4	1.6	-0.0	1.3	0.2	0.7	0.4	0.3
Tanning	0.1	0.8	2.9	-0.3	-0.4	-0.0	-1.7	-1.0	-0.7
Serious illness, injury or assault to yourself	0.1	0.2	0.5	-0.7	-0.2	-0.0	0.3	-0.6	0.1
Mouth/teeth dental problems	0.1	0.1	0.3	-0.1	0.6	-0.1	0.4	0.1	0.3
Diabetes (self-reported)	0.1	0.2	0.6	-0.5	-0.0	0.0	0.8	-0.4	0.6
Noisy workplace	0.1	0.1	0.4	0.5	-0.4	-0.0	-0.6	0.0	0.0
Mouth/teeth dental problems: Dentures	0.1	0.1	0.3	0.3	-0.5	-0.5	-0.1	-0.1	0.1
Length of working week for main job	0.1	0.1	0.2	0.5	0.1	0.4	-0.1	0.2	-0.1
Number of children fathered	0.1	0.1	0.4	-0.0	-0.3	0.6	-0.4	-0.2	-0.2
Commuting to job workplace: Walk	0.1	0.1	0.3	-0.1	-0.2	0.5	-0.2	0.2	-0.6
Medication: Gliclazide	0.1	0.2	0.4	0.4	-0.1	0.0	-0.4	0.7	0.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Supplements: Vitamin C	0.0	0.1	0.2	0.2	-0.1	0.5	0.1	0.2	-0.2

Hub : Genes

DEF6

Models

Trait associations