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chr11:60,549,966-62,346,131

Best TWAS P=7.49e-14 · Best GWAS P=1.41e-13 conditioned to 0.211

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FADS1	0.14	0.16	lasso	2	0.16	7.2e-19	-7.25	7.3	4.0e-13	-0.98	0.01	0.99	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FEN1	0.07	0.06	lasso	4	0.06	1.1e-07	-7.25	-7.2	4.5e-13	0.98	0.02	0.98	FALSE
3	GTEx	Artery Aorta	FADS2	0.18	0.17	lasso	3	0.14	3.2e-08	-5.39	-6.1	1.1e-09	0.68	0.10	0.90	FALSE
4	GTEx	Artery Tibial	FADS2	0.08	0.02	lasso	4	0.02	6.9e-03	-6.45	-5.7	1.4e-08	0.80	0.02	0.96	FALSE
5	GTEx	Artery Tibial	TMEM258	0.08	0.05	lasso	5	0.02	1.1e-02	-7.23	-7.2	5.5e-13	0.97	0.02	0.98	FALSE
6	GTEx	Brain Cerebellum	FADS1	0.35	0.24	enet	16	0.30	2.1e-09	-7.24	6.7	1.7e-11	-0.92	0.02	0.98	FALSE
7	GTEx	Brain Cerebellum	FADS3	0.26	0.18	lasso	4	0.14	5.7e-05	-7.25	7.5	7.5e-14	-0.93	0.01	0.92	TRUE
8	GTEx	Cells Transformed fibroblasts	FADS2	0.20	0.23	lasso	3	0.23	4.6e-17	-5.39	-5.4	5.2e-08	0.60	1.00	0.00	FALSE
9	GTEx	Cells Transformed fibroblasts	TMEM258	0.15	0.05	enet	15	0.07	1.1e-05	-6.45	-5.8	5.2e-09	0.78	0.04	0.96	FALSE
10	GTEx	Colon Transverse	FADS2	0.18	0.11	lasso	7	0.16	8.1e-08	-5.39	-6.7	2.8e-11	0.76	0.03	0.97	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	FADS2	0.22	0.22	lasso	2	0.20	7.8e-08	-5.39	-5.2	2.0e-07	0.58	0.14	0.82	FALSE
12	GTEx	Esophagus Mucosa	FADS1	0.11	0.00	lasso	4	0.02	1.9e-02	-6.44	5.6	2.6e-08	-0.87	0.02	0.93	FALSE
13	GTEx	Esophagus Muscularis	FADS2	0.32	0.30	lasso	6	0.31	3.7e-19	-5.39	-6.0	2.3e-09	0.71	0.90	0.10	FALSE
14	GTEx	Heart Atrial Appendage	FADS2	0.16	0.11	lasso	1	0.04	5.1e-03	-5.39	-5.4	6.9e-08	0.58	0.10	0.78	FALSE
15	GTEx	Heart Left Ventricle	FADS2	0.17	0.12	enet	3	0.13	1.5e-07	-5.43	-6.0	1.7e-09	0.71	0.23	0.76	FALSE
16	GTEx	Muscle Skeletal	FADS2	0.08	0.04	lasso	2	0.03	5.9e-04	-7.17	-7.0	1.8e-12	0.90	0.03	0.97	FALSE
17	GTEx	Nerve Tibial	FADS2	0.20	0.14	lasso	3	0.13	1.5e-09	-5.39	-5.4	5.8e-08	0.60	0.86	0.13	FALSE
18	GTEx	Pancreas	FADS1	0.17	0.13	lasso	6	0.12	1.2e-05	-7.25	7.4	9.7e-14	-0.92	0.01	0.99	FALSE
19	GTEx	Spleen	FADS2	0.30	0.27	lasso	3	0.27	1.6e-07	-5.39	-6.2	7.4e-10	0.72	0.09	0.90	FALSE
20	GTEx	Thyroid	FADS2	0.16	0.18	lasso	4	0.17	7.0e-13	-5.39	-5.4	5.8e-08	0.59	1.00	0.00	FALSE
21	GTEx	Uterus	PPP1R32	0.66	-0.01	lasso	13	0.14	8.8e-04	0.59	-5.9	4.6e-09	0.59	0.03	0.45	FALSE
22	GTEx	Whole Blood	FADS2	0.49	0.48	lasso	5	0.48	3.0e-49	-5.39	-5.5	3.8e-08	0.61	1.00	0.00	FALSE
23	METSIM	Adipose	FADS2	0.07	0.05	lasso	3	0.04	3.2e-07	-5.39	-5.2	2.1e-07	0.55	0.97	0.01	FALSE
24	NTR	Blood	C11orf10	0.06	0.08	bslmm	399	0.08	1.3e-24	-6.45	-6.8	7.6e-12	0.92	0.08	0.92	FALSE
25	NTR	Blood	FADS2	0.30	0.33	lasso	7	0.33	9.0e-109	-5.39	-5.7	1.2e-08	0.63	1.00	0.00	FALSE
26	ROSMAP	Brain Pre-frontal Cortex	TMEM258	0.14	0.16	lasso	4	0.15	4.7e-19	-6.45	-6.5	5.9e-11	0.94	0.08	0.92	FALSE
27	ROSMAP	Brain Pre-frontal Cortex	FADS1	0.08	0.08	enet	10	0.09	1.5e-11	-7.30	7.1	1.1e-12	-0.97	0.01	0.99	FALSE
28	YFS	Blood	FADS1	0.11	0.08	lasso	8	0.09	6.1e-29	-5.39	-6.5	7.0e-11	0.77	1.00	0.00	FALSE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	FADS2	0.05	0.04	lasso	2	0.04	2.2e-09	-5.39	-5.3	1.2e-07	0.56	0.98	0.02	FALSE
30	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FADS1	0.06	0.03	lasso	4	0.04	7.4e-03	-7.25	7.4	9.9e-14	-0.83	0.01	0.77	FALSE
31	The Cancer Genome Atlas	Colon Adenocarcinoma	FADS2	0.30	0.21	lasso	2	0.22	6.7e-13	-5.39	-6.3	3.7e-10	0.76	0.72	0.28	FALSE
32	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FADS2	0.05	0.04	lasso	3	0.05	1.9e-06	-5.39	-5.6	1.6e-08	0.71	0.22	0.74	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FADS2	0.26	0.29	enet	15	0.29	2.9e-33	-5.39	-6.2	4.2e-10	0.73	1.00	0.00	FALSE
34	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FADS2	0.33	0.27	lasso	9	0.35	9.3e-21	-5.39	-6.5	8.4e-11	0.79	0.39	0.61	FALSE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	FADS1	0.05	0.05	blup	53	0.04	6.8e-05	-5.37	5.9	3.4e-09	-0.87	0.04	0.95	FALSE
36	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	FADS1	0.20	0.01	blup	51	0.07	3.2e-04	-7.20	5.6	2.0e-08	-0.85	0.02	0.93	FALSE
37	The Cancer Genome Atlas	Lung Adenocarcinoma	FADS2	0.04	0.04	lasso	4	0.02	1.7e-03	-5.39	-5.5	3.9e-08	0.62	0.06	0.78	FALSE
38	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FADS2	0.02	0.01	blup	71	0.02	1.9e-03	-7.17	-6.6	3.7e-11	0.91	0.02	0.80	FALSE
39	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FADS2	0.15	0.16	lasso	2	0.12	8.8e-06	-5.39	-5.3	1.2e-07	0.59	0.42	0.39	FALSE
40	The Cancer Genome Atlas	Prostate Adenocarcinoma	FADS1	0.06	0.04	blup	53	0.03	2.0e-04	-7.24	5.2	2.4e-07	-0.71	0.01	0.90	FALSE
41	The Cancer Genome Atlas	Prostate Adenocarcinoma	FADS2	0.07	0.07	lasso	4	0.06	1.9e-06	-5.39	-5.6	1.8e-08	0.70	0.19	0.79	FALSE
42	The Cancer Genome Atlas	Rectum Adenocarcinoma	FADS2	0.47	0.34	lasso	5	0.30	7.9e-08	-5.39	-6.0	2.3e-09	0.68	0.03	0.95	FALSE
43	The Cancer Genome Atlas	Stomach Adenocarcinoma	FADS2	0.15	0.05	blup	71	0.11	2.5e-08	-5.39	-6.7	2.0e-11	0.72	0.05	0.95	FALSE
44	The Cancer Genome Atlas	Thyroid Carcinoma	C11orf10	0.02	0.02	blup	44	0.02	1.8e-03	-5.61	-6.9	4.8e-12	0.95	0.02	0.74	FALSE
45	The Cancer Genome Atlas	Thyroid Carcinoma	FADS2	0.30	0.33	lasso	8	0.33	5.6e-33	-5.39	-6.2	7.4e-10	0.71	1.00	0.00	FALSE