Best TWAS P=3.22e-09 · Best GWAS P=3.26e-08 conditioned to 0.657
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ARFRP1 | 0.07 | 0.07 | lasso | 3 | 0.06 | 5.3e-08 | -5.3 | 5.6 | 1.9e-08 | -0.89 | 0.03 | 0.97 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | STMN3 | 0.07 | 0.02 | lasso | 4 | 0.05 | 2.8e-06 | -5.5 | -5.7 | 1.0e-08 | 0.76 | 0.02 | 0.98 | FALSE |
3 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | STMN3 | 0.02 | 0.02 | blup | 43 | 0.02 | 1.7e-03 | -5.5 | -5.5 | 4.7e-08 | 0.86 | 0.01 | 0.92 | FALSE |
4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SLC2A4RG | 0.03 | 0.01 | blup | 48 | 0.02 | 2.4e-03 | -5.2 | 5.9 | 3.2e-09 | -0.90 | 0.01 | 0.89 | TRUE |
5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LIME1 | 0.02 | 0.03 | blup | 47 | 0.02 | 6.2e-03 | -5.4 | -5.4 | 8.7e-08 | 0.93 | 0.01 | 0.88 | FALSE |
6 | The Cancer Genome Atlas | Lung Adenocarcinoma | TNFRSF6B | 0.02 | 0.01 | enet | 7 | 0.01 | 6.9e-03 | -5.2 | -5.6 | 2.2e-08 | 0.93 | 0.01 | 0.89 | FALSE |
7 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | STMN3 | 0.07 | 0.01 | blup | 41 | 0.05 | 4.2e-04 | -4.8 | -5.7 | 1.2e-08 | 0.79 | 0.04 | 0.73 | FALSE |
8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ARFRP1 | 0.03 | 0.02 | lasso | 2 | 0.02 | 1.2e-03 | -5.3 | 5.3 | 1.1e-07 | -0.78 | 0.02 | 0.88 | FALSE |
9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LIME1 | 0.04 | 0.05 | blup | 47 | 0.05 | 9.0e-06 | -4.9 | -5.2 | 2.0e-07 | 0.80 | 0.04 | 0.95 | FALSE |
10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SLC2A4RG | 0.05 | 0.01 | blup | 48 | 0.02 | 2.0e-03 | -5.0 | 5.4 | 8.7e-08 | -0.75 | 0.03 | 0.83 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZGPAT | 0.05 | 0.06 | lasso | 3 | 0.06 | 5.5e-07 | -5.5 | 5.6 | 2.1e-08 | -0.99 | 0.01 | 0.99 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | ARFRP1 | 0.04 | 0.00 | blup | 51 | 0.00 | 1.3e-01 | -4.8 | 5.7 | 1.4e-08 | -0.76 | 0.01 | 0.57 | FALSE |