TWAS hub - ZGPAT

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Coronary	0.2670	0.0920	9.0e-03	0.026	NA	0.033	NA	-0.009	4.4e-02	NA	2.8e-02	NA	9.7e-01
2	GTEx	Brain Cortex	0.4070	0.1140	4.1e-03	-0.003	NA	-0.009	NA	-0.011	3.9e-01	NA	7.0e-01	NA	9.7e-01
3	TCGA	Brain Lower Grade Glioma	0.0524	0.0225	2.4e-06	0.038	0.055	0.030	NA	0.037	3.7e-05	7.2e-07	2.3e-04	NA	4.8e-05
4	TCGA	Prostate Adenocarcinoma	0.0544	0.0289	1.0e-05	0.056	0.045	0.058	NA	0.061	1.7e-06	1.5e-05	1.1e-06	NA	5.5e-07
5	TCGA	Thyroid Carcinoma	0.0490	0.0230	4.7e-05	0.040	0.035	0.033	NA	0.029	8.8e-05	2.3e-04	3.3e-04	NA	7.5e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	3	4	5
Irritable Bowel Disease (IBD)	12.4	29.6	71.6	3.2	5.9	8.5	5.6
Crohns Disease (2012)	10.0	16.1	42.0	0.6	4.1	6.5	4.7
Allergy or Eczema	10.0	26.3	45.6	2.8	6.1	6.8	6.3
Ulcerative Colitis (UC)	9.9	18.6	35.7	3.5	5.1	6.0	4.3
Ulcerative Colitis	9.8	14.3	32.2	2.2	4.2	5.7	4.1
Prostate Cancer	9.3	13.1	26.5	2.7	4.2	5.1	3.7
Allergy	9.1	20.9	41.0	-1.2	-5.3	-6.4	-5.8
Hayfever, allergic rhinitis or eczema	8.7	18.8	30.2	3.1	5.5	5.3	5.1
Crohns Disease (2017)	7.3	16.1	45.6	1.5	3.9	6.8	4.2
Diastolic blood pressure, automated reading	6.9	21.5	36.5	2.3	5.8	5.7	6.0
Wheeze or whistling in the chest in last year	6.7	12.0	33.2	0.2	2.9	5.8	4.3
Medication: Blood pressure	6.3	12.0	23.4	1.0	4.2	4.2	4.8
Number of self-reported non-cancer illnesses	6.2	10.7	23.6	0.6	3.7	4.9	4.0
Respiratory disease	5.6	12.4	31.4	-0.9	3.1	5.6	4.5
Asthma	5.3	10.5	23.8	-1.2	3.0	4.9	4.3
Systolic blood pressure, automated reading	5.2	15.1	31.3	0.6	4.7	4.7	5.6
Current tobacco smoking	5.0	8.2	20.9	1.9	3.0	4.6	2.8
Lung FVC	4.8	24.3	86.7	-1.4	-3.4	-9.3	-4.6
Medication for cholesterol	4.8	7.2	15.6	-0.7	-3.3	-3.0	-3.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.6	5.4	10.2	0.6	3.2	2.7	3.1
Asthma (self-reported)	4.6	9.2	21.1	-1.0	2.9	4.6	4.0
Smoking status: Current	4.3	6.8	17.8	1.6	2.7	4.2	2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	4.2	5.6	9.9	2.0	2.7	3.1	2.6
Forced vital capacity (FVC)	3.6	14.0	44.7	-0.5	-2.9	-6.7	-4.1
Pain all over the body in last month	3.5	3.8	9.2	1.9	1.6	3.0	1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	3.4	5.2	8.7	1.8	2.9	2.5	2.8
Systolic Blood Pressure	3.3	16.4	30.1	1.9	5.1	4.7	5.5
Qualifications: College or University degree	3.2	10.2	18.1	-2.8	-3.6	-4.3	-3.5
Vascular/heart problems diagnosed by doctor	3.2	8.7	17.6	-1.1	-3.7	-3.4	-4.2
High blood pressure	3.0	8.5	17.5	1.0	3.6	3.3	4.2
Hypertension (Self-reported)	3.0	8.5	17.8	0.9	3.6	3.3	4.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.0	6.3	24.6	0.2	-1.4	-5.0	-2.3
Other serious medical condition/disability diagnosed by doctor	2.9	3.7	7.2	-0.1	2.2	2.6	2.7
Mouth/teeth dental problems: Dentures	2.8	4.8	8.2	1.8	2.4	2.9	2.5
Smoking Status	2.7	6.4	16.0	1.1	2.3	4.0	3.0
Medication for pain relief, constipation, heartburn	2.7	4.6	8.7	-1.5	-2.6	-2.3	-3.0
Illness, injury, bereavement, stress in last 2 years	2.7	3.4	6.6	-2.6	-1.6	-2.3	-1.5
Long-standing illness, disability or infirmity	2.7	4.1	10.7	-1.8	1.1	3.3	2.3
Maternal smoking around birth	2.6	3.8	7.2	-1.3	1.9	2.5	2.7
Qualifications: NVQ or HND or HNC or equivalent	2.6	3.1	4.9	1.4	2.0	2.2	2.1
Medication: Ramipril	2.5	3.2	6.1	-0.9	2.0	2.5	2.3
Forced vital capacity (FVC), Best measure	2.4	8.9	29.2	-1.2	-2.3	-5.4	-3.0
Migraine (self-reported)	2.4	3.0	5.7	1.0	2.4	1.8	2.2
Leg fat percentage (left)	2.4	8.6	25.6	1.7	1.9	5.1	3.3
Myopia	2.4	3.5	7.6	0.6	-2.3	-2.1	-2.8
Taking other prescription medications	2.3	3.5	6.9	-1.2	1.8	2.5	2.6
Had menopause	2.3	2.9	4.8	1.4	1.7	2.1	2.2
Forced expiratory volume in 1-second (FEV1)	2.3	7.6	27.7	0.4	-1.5	-5.3	-2.8
Medication: Omeprazole (e.g. Zanprol)	2.3	2.9	8.5	1.6	1.2	2.9	1.4
Cardiovascular Disease	2.2	7.3	15.1	1.0	2.9	3.9	3.5
Hip circumference	2.2	9.5	23.0	0.1	2.6	4.8	4.2
Blood Platelet Count	2.1	24.1	59.8	1.3	4.7	7.7	6.1
Number of treatments/medications taken	2.1	3.7	6.8	0.1	2.3	2.6	2.6
Impedance of arm (right)	2.1	9.6	24.2	1.0	-4.2	-2.2	-4.9
Impedance of arm (left)	2.1	9.6	24.5	1.2	-4.0	-2.4	-5.0
Leg fat percentage (right)	2.0	7.4	21.5	1.7	1.8	4.6	3.0
Depression (Nagel 2018)	1.9	2.8	6.2	1.1	1.7	2.5	2.0
Schizophrenia (2018)	1.9	3.9	6.8	-1.3	-2.3	-2.3	-2.6
Blood Red Count	1.9	18.7	33.4	2.3	5.3	5.8	5.1
Pack years adult smoking proportion	1.9	2.8	6.2	0.8	1.9	2.5	1.9
Lung cancer (father)	1.9	2.2	4.6	-0.2	2.1	1.7	1.9
Ovarian Cancer	1.8	2.3	4.7	2.2	1.8	1.5	1.2
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	5.4	-2.3	1.2	0.9	1.7
Financial difficulties in last 2 years	1.8	2.4	4.4	1.5	1.5	2.1	1.8
Qualifications: O levels/GCSEs or equivalent	1.8	2.8	6.2	0.7	2.5	1.4	2.3
Arm predicted mass (right)	1.8	9.0	19.5	-0.4	3.3	3.8	4.4
Illnesses of siblings: Diabetes	1.8	2.2	3.9	1.1	1.7	2.0	1.8
Eye problems/disorders: Cataract	1.8	2.1	3.4	-1.5	-1.8	-1.2	-1.8
Pack years of smoking	1.8	2.6	5.2	1.0	1.9	2.3	1.8
LDL Cholesterol	1.7	2.6	4.7	-1.4	-1.7	-2.2	-1.8
Type 2 Diabetes (T2D) (2018)	1.7	3.1	9.4	0.5	1.1	3.1	2.1
Waist circumference	1.7	6.2	18.7	-0.1	1.4	4.3	3.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.4	20.3	-0.2	-1.3	-4.5	-2.2
Medication: Ventolin 100micrograms inhaler	1.7	2.1	7.0	-0.7	1.0	2.6	1.5
Arm fat-free mass (right)	1.7	8.8	19.7	-0.4	3.2	3.7	4.4
Medication: Lisinopril	1.7	2.2	7.9	2.8	1.3	0.7	0.8
Arm fat-free mass (left)	1.7	8.5	18.6	-0.2	2.9	3.9	4.3
Leg fat mass (left)	1.7	6.5	19.8	0.8	1.6	4.5	3.1
Alzheimer’s Disease (including proxy)	1.6	2.3	4.9	-1.1	-2.2	-1.3	-2.0
Number of incorrect matches in round	1.6	2.7	6.2	-1.8	-1.3	-2.5	-1.5
Worrier / anxious feelings	1.6	3.0	7.2	2.7	1.7	1.5	1.6
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.6	6.1	2.1	0.9	2.5	1.4
Leg fat mass (right)	1.6	6.2	18.4	0.8	1.6	4.3	3.0
Rheumatoid Arthritis	1.5	2.1	4.0	-0.4	1.7	1.8	2.0
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	3.1	0.3	-1.7	-1.7	-1.7
High blood pressure (mother)	1.5	2.2	3.4	1.8	1.6	1.7	1.4
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	5.8	-0.5	1.2	2.4	1.9
Whole body fat mass	1.5	6.3	21.0	0.6	1.3	4.6	2.9
Arm predicted mass (left)	1.5	7.7	16.7	-0.3	2.7	3.8	4.1
Bipolar Disorder or Schizophrenia	1.4	3.3	5.8	-0.7	-2.3	-2.3	-2.4
Alzheimer’s Disease (in mother)	1.4	1.7	3.4	-1.2	-1.9	-1.0	-1.6
Lung FEV1/FVC ratio	1.4	7.3	15.3	3.9	3.2	1.9	2.7
Medication: Co-codamol	1.4	1.7	3.0	1.7	1.1	1.7	1.1
Severe depression (siblings)	1.4	1.6	4.1	1.1	0.8	2.0	1.4
Qualifications: CSEs or equivalent	1.4	1.9	4.8	0.2	1.3	2.2	1.7
Medication: Atenolol	1.4	1.7	3.3	0.5	1.8	1.6	1.6
Chronic bronchitis/emphysema (mother)	1.4	1.6	3.5	-1.8	0.3	1.9	1.0
BMI	1.3	7.7	16.3	-1.1	2.3	4.0	4.0
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	4.4	1.3	1.1	2.1	1.2
Prospective memory result	1.3	1.6	3.0	-1.7	-1.3	-0.6	-1.7
Angina (self-reported)	1.3	1.8	3.6	-0.8	1.7	1.3	1.9
Medication: Omeprazole	1.3	1.6	4.3	1.6	0.7	2.1	0.7
Chest pain or discomfort	1.3	1.8	7.6	-2.8	-0.5	1.1	0.3
Commuting to job workplace: Cycle	1.3	1.6	3.7	0.6	-1.4	-1.9	-1.4
Schizophrenia (2014)	1.2	2.7	5.2	-0.7	-2.1	-1.9	-2.3
Blood White Count	1.2	9.2	21.2	2.3	3.1	4.6	3.1
Angina	1.2	1.5	3.2	-0.8	1.6	1.1	1.8
Diabetes (father)	1.2	1.4	3.3	0.1	1.2	1.8	1.5
Supplements: Glucosamine	1.2	1.6	3.0	0.1	1.5	1.7	1.7
Chronic bronchitis/emphysema (father)	1.2	1.5	5.9	-0.3	0.4	2.4	1.1
Hair/balding pattern: Pattern 2	1.2	1.6	2.9	1.1	1.2	1.7	1.5
Illnesses of mother	1.2	1.5	3.5	-0.7	-1.3	-1.9	-1.5
Body fat percentage	1.2	4.7	18.2	1.0	0.7	4.3	2.0
Age at first live birth	1.2	2.2	5.8	-1.0	-1.3	-2.4	-1.6
Emphysema/chronic bronchitis	1.2	1.4	3.3	1.7	0.7	1.8	0.5
Tinnitus: Yes, now most or all of the time	1.2	1.4	3.2	1.1	1.8	0.3	1.6
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	6.0	-2.5	-0.5	1.1	0.2
Primary Biliary Cirrhosis	1.1	1.6	3.8	0.7	1.3	2.0	1.4
Body mass index (BMI)	1.1	4.7	11.1	-0.2	1.6	3.3	3.1
Weight	1.1	5.2	15.0	0.1	1.4	3.9	3.0
Depression (self-reported)	1.1	1.3	2.1	-1.0	-1.4	-1.3	-1.4
Blood clot in the leg (DVT)	1.1	1.4	5.8	-2.4	-0.3	1.0	0.3
Medication: Paracetamol	1.1	1.9	4.4	0.7	1.9	0.8	2.1
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	5.7	0.1	-1.1	-2.4	-1.4
Pain experienced in last month	1.1	1.8	5.6	-0.4	-0.7	-2.4	-1.6
HDL Cholesterol	1.0	1.7	5.2	-1.1	-0.8	-2.3	-1.1
Hypothyroidism (self reported)	1.0	2.3	10.1	-3.2	0.0	-0.3	1.1
Trunk fat mass	1.0	4.4	17.3	0.6	0.6	4.2	2.1
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.3	-1.5	0.4	1.5	1.2
Arm fat mass (right)	1.0	4.2	13.8	0.0	0.9	3.7	2.5
Medication: Amlodipine	1.0	1.4	3.3	0.4	1.7	0.9	1.8
Medication: Blood pressure	1.0	1.8	3.6	-0.1	1.9	1.3	1.9
Pulse rate, automated reading	1.0	3.4	7.8	2.8	1.5	2.4	1.1
Diabetes diagnosed by doctor	1.0	1.6	5.4	-0.7	0.1	2.3	1.4
Arm fat mass (left)	1.0	4.1	13.1	-0.1	0.9	3.6	2.5
Impedance of whole body	1.0	5.2	14.0	2.3	-2.5	-0.8	-3.7
Relative age of first facial hair	0.9	1.8	3.4	-0.3	1.7	1.6	1.9
Trunk fat percentage	0.9	3.6	15.2	0.8	0.1	3.9	1.4
Average weekly fortified wine intake	0.9	1.1	2.4	-0.5	-1.6	-1.0	-1.3
Hearing difficulty/problems with background noise	0.9	1.4	2.4	0.9	1.4	1.3	1.5
Diabetes (self-reported)	0.9	1.4	4.7	0.0	0.7	2.2	1.4
Medication: Seretide 50 evohaler	0.9	1.1	2.1	-0.5	1.1	1.4	1.3
Medication: Bendroflumethiazide	0.9	1.3	2.4	1.0	0.9	1.6	1.5
Neuroticism	0.8	1.8	4.7	0.5	1.7	1.1	2.2
Frequency of depressed mood in last 2 weeks	0.8	1.2	2.5	0.9	1.0	1.6	1.3
Pulse rate	0.8	1.4	6.6	2.6	0.3	0.1	-0.2
Trunk predicted mass	0.8	4.3	10.7	-0.9	2.0	2.5	3.3
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	5.5	-2.4	0.5	0.1	1.3
Breast cancer (self-reported)	0.8	0.9	2.5	-0.2	-1.1	-1.6	-1.0
Ever taken oral contraceptive pill	0.8	0.9	1.5	1.2	1.1	0.9	0.9
Basal metabolic rate	0.8	4.5	10.1	-0.7	1.7	3.0	3.2
Fractured/broken bones in last 5 years	0.8	1.0	2.2	-1.5	-1.4	-0.4	-0.8
Ever depressed for a whole week	0.8	1.0	2.3	-1.0	1.1	0.7	1.5
Alcohol drinker status: Previous	0.8	0.9	2.9	0.3	0.7	1.7	0.9
Reaction Time	0.7	1.3	2.8	1.7	0.9	1.4	1.0
Breast Cancer	0.7	1.7	2.9	0.8	1.7	1.3	1.7
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.5	0.0	-1.2	-1.0	-1.2
Medication: Levothyroxine sodium	0.7	1.2	4.6	-2.1	0.5	-0.0	1.2
Trunk fat-free mass	0.7	4.3	10.8	-0.9	2.0	2.4	3.3
Alcohol intake versus 10 years previously	0.7	1.0	1.6	1.2	0.9	1.1	1.3
Hair/balding pattern: Pattern 3	0.7	1.1	2.3	-0.2	1.5	1.0	1.5
Tense / ‘highly strung’	0.7	1.1	2.6	-0.9	1.0	1.1	1.6
Medication: Aspirin	0.7	1.0	2.0	0.3	1.1	1.4	1.3
Whole body fat-free mass	0.7	4.0	9.7	-0.9	1.7	2.5	3.1
Whole body water mass	0.7	4.2	10.4	-0.9	1.8	2.6	3.2
Guilty feelings	0.7	1.0	1.6	-0.8	-1.3	-1.2	-1.2
Financial situation satisfaction	0.7	0.8	1.6	-0.5	-1.3	-1.1	-1.0
Medication: Atorvastatin	0.7	0.9	4.4	2.1	0.3	0.1	0.2
Irritability	0.7	1.2	2.3	-0.3	1.2	1.5	1.5
Verbal and Numeric Reasoning (VNR)	0.6	1.5	3.3	0.3	1.3	1.8	1.6
Age at First Birth	0.6	0.9	1.9	0.2	-0.8	-1.3	-1.4
Lupus	0.6	0.8	1.9	-1.4	1.0	0.9	0.8
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.7	0.0	0.5	1.6	0.8
Chronotype (morning person)	0.6	1.4	3.8	0.4	1.9	0.6	1.7
Fed-up feelings	0.6	1.2	3.3	-1.8	0.3	1.2	1.1
Impedance of leg (left)	0.6	2.8	10.3	3.2	-0.0	1.4	-1.2
Mouth/teeth dental problems	0.6	1.0	2.8	-1.7	-0.5	-1.0	-0.8
Arm fat percentage (right)	0.6	2.3	9.6	0.1	-0.1	3.1	1.4
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.7	1.6	0.1	0.6	-0.5
Birth weight	0.6	1.3	2.3	1.5	-1.1	-1.0	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.1	-1.1	1.0	-1.0	0.5
Heart disease (mother)	0.6	0.7	1.6	-1.3	0.1	1.1	0.9
Arm fat percentage (left)	0.6	2.2	9.1	0.1	0.0	3.0	1.4
Average weekly red wine intake	0.6	0.8	2.1	0.2	1.3	0.4	1.4
Osteoarthritis (self-reported)	0.6	0.8	1.6	1.3	1.2	0.7	0.8
Medication: Aspirin	0.6	0.8	1.2	0.7	1.1	1.1	1.1
High cholesterol (Self-reported)	0.6	1.0	3.3	-0.3	-1.8	-0.2	-1.3
Number of operations (self-reported)	0.6	0.8	1.6	-0.5	1.0	1.2	1.3
Average weekly beer plus cider intake	0.6	0.8	2.8	1.0	0.2	1.7	0.4
Risk taking	0.6	0.9	2.5	-0.1	-1.6	-0.7	-1.3
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.1	-0.6	-0.9	-1.5	-0.6
Depressed Affect (Nagel 2018)	0.5	1.2	3.9	-2.0	-0.1	1.0	0.9
Medication for hormone replacement therapy	0.5	0.5	1.0	0.4	1.0	-0.8	0.8
Diabetes (mother)	0.5	0.6	1.1	-0.3	0.8	1.1	1.1
Impedance of leg (right)	0.5	2.4	8.7	3.0	-0.1	1.0	-1.4
Leg fat-free mass (left)	0.5	2.4	5.1	-1.2	0.8	2.2	2.3
Relative age voice broke	0.5	0.8	1.7	-0.6	1.1	0.7	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.6	-1.6	0.6	0.2	1.5
Falls in the last year	0.5	0.7	1.4	-1.2	-0.8	1.1	0.2
Noisy workplace	0.5	0.6	0.9	-0.7	0.9	0.9	0.9
Pulse wave reflection index	0.5	0.6	2.2	-1.5	0.1	-0.7	0.4
Loud music exposure frequency	0.5	0.5	1.8	-1.3	-0.8	0.3	-0.1
Glaucoma (self-reported)	0.5	0.6	1.4	1.2	1.0	0.2	0.7
Gout (self-reported)	0.5	0.7	1.7	0.2	-1.3	-1.1	-0.7
Eye problems/disorders: None of the above	0.5	0.6	1.0	0.8	0.9	0.6	1.0
Neck or shoulder pain in last month	0.5	0.7	3.1	1.8	0.5	0.1	0.4
Alcohol intake frequency.	0.5	1.1	4.6	2.2	-0.1	0.8	-0.1
Knee pain experienced in last month	0.5	0.7	2.2	-0.2	0.5	1.5	1.1
Medication: Gliclazide	0.5	0.5	1.4	1.2	0.3	1.0	0.5
Illnesses of father: None of the above (group 1)	0.5	0.6	1.5	0.7	-0.3	-1.2	-0.9
Leg predicted mass (right)	0.5	2.5	5.5	-1.1	0.9	2.2	2.4
Miserableness	0.5	0.9	2.5	1.2	0.5	1.6	0.7
Neuroticism (2016)	0.4	0.6	1.5	0.8	1.0	0.0	1.2
Ever had hysterectomy (womb removed)	0.4	0.4	1.1	-1.1	0.5	0.7	0.6
Medication: Metformin	0.4	0.5	1.5	-0.7	-0.7	1.2	0.3
Hand grip strength (right)	0.4	1.0	2.4	1.2	1.6	0.6	0.8
Serious illness, injury or assault to yourself	0.4	0.4	1.5	1.2	0.4	0.7	0.3
Leg predicted mass (left)	0.4	2.3	4.8	-1.2	0.7	2.1	2.2
Fluid intelligence score	0.4	0.7	2.0	1.4	0.7	0.7	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.6	1.3	-0.7	0.0	-0.8
Pulse wave peak to peak time	0.4	0.4	1.6	-1.3	0.2	0.6	0.2
Medication: Ibuprofen	0.4	0.5	1.0	1.0	-0.5	-0.5	-1.0
Overall health rating	0.4	0.9	3.6	0.1	0.1	1.9	0.9
Family relationship satisfaction	0.4	0.5	0.9	-1.0	-0.0	0.9	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.6	-1.3	-0.6	0.6	0.0
Illnesses of father: Heart disease	0.4	0.6	0.9	-0.8	-0.9	-1.0	-0.6
Leg fat-free mass (right)	0.4	2.2	5.1	-1.1	0.8	2.1	2.2
Loneliness, isolation	0.4	0.5	1.3	-0.8	-0.7	1.1	0.3
Ever had bowel cancer screening	0.4	0.5	1.1	-0.4	0.6	0.9	1.1
Hearing aid user	0.4	0.4	1.2	-0.6	0.4	1.1	0.7
Basal cell carcinoma (self-reported)	0.4	0.4	0.9	1.0	-0.7	0.3	-0.8
Neuroticism (Nagel 2018)	0.3	0.7	2.1	-0.7	0.7	0.4	1.4
Worry (Nagel 2018)	0.3	0.7	2.1	0.4	1.1	-0.1	1.4
Triglycerides	0.3	0.5	2.0	-0.4	-0.3	1.4	0.0
Height	0.3	5.8	17.9	2.2	1.7	4.2	1.8
Average weekly spirits intake	0.3	0.4	1.3	-0.1	0.4	1.2	0.8
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.6	0.8	0.7	0.2	0.8
Age when periods started (menarche)	0.3	0.7	1.5	1.2	-0.1	-0.8	-1.2
Past tobacco smoking	0.3	0.6	1.5	-1.0	-0.6	-0.4	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	2.2	-0.7	0.7	0.2	1.5
Number of live births	0.3	0.4	1.9	-0.5	-0.1	1.4	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	1.1	1.1	0.6	0.0	0.3
Pulse wave Arterial Stiffness index	0.3	0.3	1.5	1.2	-0.2	-0.4	-0.1
Length of working week for main job	0.3	0.4	1.6	-1.3	0.1	0.4	0.2
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.7	0.9	-0.5	-0.8	-0.4
Comparative body size at age 10	0.3	0.9	1.8	0.9	-1.3	-0.5	-1.3
Health satisfaction	0.3	0.4	1.1	1.1	0.4	0.6	0.4
Medication: Allopurinol	0.3	0.5	1.0	0.8	-0.7	-1.0	-0.3
Mean time to correctly identify matches	0.3	0.6	1.0	0.7	0.7	1.0	0.9
Leg pain on walking	0.3	0.4	0.8	-0.1	0.7	0.9	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.5	0.6	1.0	1.2	0.6
Friendships satisfaction	0.3	0.4	1.5	-1.2	-0.5	0.0	0.1
Commuting to job workplace: Walk	0.3	0.3	0.6	0.7	0.5	0.8	0.6
Mineral and other dietary supplements	0.3	0.4	1.3	1.1	0.1	-0.6	-0.6
Wears glasses or contact lenses	0.3	0.3	0.5	-0.6	-0.7	-0.6	-0.6
Mother’s age at death	0.3	0.4	1.4	-1.2	-0.5	-0.3	-0.3
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.7	-0.8	-0.7	0.7	-0.2
Unable to work because of sickness or disability	0.3	0.3	0.8	-0.8	-0.5	0.9	-0.2
Supplements: Calcium	0.3	0.4	1.8	-1.3	-0.1	-0.0	0.2
Heart disease (siblings)	0.3	0.4	1.0	0.2	0.8	0.4	1.0
Bipolar Disorder (2018)	0.2	0.3	0.6	0.2	-0.8	-0.7	-0.6
Schizophrenia vs Biploar Disorder	0.2	0.3	0.4	-0.6	-0.4	0.6	-0.5
Body Mass Index (BMI) (2010)	0.2	0.2	1.0	-1.0	-0.0	-0.1	0.1
Mean Putamen Volume	0.2	0.2	0.8	0.9	0.5	-0.2	-0.1
HbA1C	0.2	0.2	0.3	-0.6	-0.5	-0.4	-0.6
Heel T-Score	0.2	1.2	3.6	-0.7	1.0	-1.9	1.0
Waist Hip Ratio (WHR)	0.2	0.7	1.6	0.6	-1.2	1.0	-0.8
Hand grip strength (left)	0.2	0.6	1.5	0.9	1.2	0.6	0.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.7	-0.1	0.4	0.7	0.8
Townsend deprivation index at recruitment	0.2	0.3	1.0	0.2	-1.0	-0.3	-0.6
Stomach or abdominal pain in last month	0.2	0.3	1.2	-1.1	-0.2	-0.1	-0.0
Sitting height	0.2	1.3	2.0	-1.2	-1.4	-1.4	-1.1
Alcohol usually taken with meals	0.2	0.3	0.5	-0.5	0.7	-0.7	0.7
Had other major operations	0.2	0.2	0.6	0.5	0.4	0.8	0.3
Heart attack	0.2	0.3	0.4	-0.6	0.7	-0.4	0.5
Medication: Simvastatin	0.2	0.3	0.5	-0.7	-0.7	0.3	-0.5
Neuroticism score	0.2	0.3	0.8	-0.2	0.4	0.8	0.9
Happiness	0.2	0.3	0.7	0.2	0.6	0.6	0.9
Medication: Lansoprazole	0.2	0.2	0.8	0.3	-0.0	0.9	0.4
Hair/balding pattern: Pattern 4	0.2	0.6	1.1	0.8	1.0	0.6	0.9
Peak expiratory flow (PEF)	0.2	0.6	1.7	1.3	0.7	-0.8	0.1
Headache pain in last month	0.2	0.4	1.1	1.1	0.3	0.7	0.6
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.8	0.5	-0.6	-0.8	-0.9
Number of full brothers	0.2	0.3	0.6	-0.5	-0.6	0.8	-0.3
Number of children fathered	0.2	0.2	0.9	-0.9	0.1	0.3	0.4
Shortness of breath walking on level ground	0.2	0.2	0.8	0.3	0.1	0.9	0.6
Comparative height size at age 10	0.2	1.3	3.3	-1.0	-1.8	-0.1	-1.4
Suffer from ‘nerves’	0.2	0.2	1.1	1.1	0.1	-0.1	0.2
Age at last live birth	0.2	0.4	1.2	0.0	-0.6	-1.1	-0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.5	-0.3	0.7	0.5	0.3
Smoking status: Previous	0.2	0.2	0.5	0.5	-0.0	-0.6	0.7
Mood swings	0.2	0.3	1.5	-0.1	-0.3	1.2	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.3	0.5	-0.5	0.5	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	0.6	0.5	0.3	0.6
Back pain experienced in last month	0.2	0.3	1.3	-0.6	-1.1	-0.0	-0.4
Osteoporosis (self-reported)	0.2	0.2	0.3	-0.5	-0.5	-0.5	-0.5
Average weekly champagne plus white wine intake	0.2	0.2	0.5	-0.7	0.5	-0.4	0.4
Medication: Paracetamol	0.2	0.2	0.6	0.8	0.6	0.2	0.5
Alcohol drinker status: Never	0.2	0.3	0.9	1.0	-0.3	0.0	-0.5
Ever smoked	0.2	0.4	1.4	1.2	0.3	-0.1	0.8
Age started oral contraceptive pill	0.2	0.2	0.6	-0.8	0.3	-0.2	0.6
Cholesterol lowering medication	0.2	0.3	1.1	1.1	-0.1	0.6	0.3
Blood Eosinophil Count	0.1	1.0	2.4	-0.1	-1.4	1.6	-0.8
Hair Pigment	0.1	3.6	8.0	1.9	1.8	2.8	1.9
Tanning	0.1	1.0	4.5	-2.1	0.4	-0.2	0.8
Hearing difficulty/problems: Yes	0.1	0.2	0.5	-0.4	0.2	0.6	0.7
Vitamin and mineral supplements	0.1	0.1	0.4	-0.3	-0.6	0.1	-0.5
Supplements: Zinc	0.1	0.1	0.3	0.6	-0.1	-0.1	-0.2
Multivitamins +/- minerals	0.1	0.1	0.5	-0.7	-0.0	-0.4	0.1
Nervous feelings	0.1	0.1	0.6	0.3	-0.1	-0.7	-0.0
Illnesses of siblings	0.1	0.1	0.3	-0.1	-0.0	-0.5	-0.5
Father’s age at death	0.1	0.1	0.2	-0.5	0.2	-0.3	-0.1
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.5	-0.7	-0.4	-0.4	-0.1
Standing height	0.1	0.7	3.0	0.7	-0.0	1.7	0.4
Exposure to tobacco smoke at home	0.1	0.2	0.6	-0.2	-0.8	0.0	-0.4
Birth weight of first child	0.1	0.1	0.4	-0.4	-0.6	0.3	-0.3
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.1	-0.3	0.3	0.3	0.3
Exposure to tobacco smoke outside home	0.1	0.1	0.3	-0.3	-0.2	0.5	0.1
Worry too long after embarrassment	0.1	0.2	0.4	0.1	0.6	-0.4	0.5
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.5	0.3	-0.5	0.7	-0.2
Number of full sisters	0.1	0.1	0.4	0.5	0.0	0.6	-0.0
Had major operations	0.1	0.1	0.4	0.3	0.1	-0.6	-0.0
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.4	0.2	0.5	0.4
Qualifications: nursing, teaching	0.1	0.2	0.6	-0.5	-0.1	-0.8	-0.3
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.4	-0.4	0.2	0.5
Eye problems/disorders: Glaucoma	0.1	0.2	0.4	0.7	0.6	0.1	0.3
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.3	-0.5	-0.1	0.6	0.3
Illnesses of father: High blood pressure	0.1	0.2	0.4	-0.6	0.2	0.5	0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.4	-0.5	0.6	-0.4	0.4
Intelligence (Savage-Jansen 2018)	0.0	0.0	0.1	0.3	-0.1	-0.2	-0.1
Alzheimer’s Disease (in father)	0.0	0.1	0.2	-0.2	-0.0	0.5	0.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.2	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.1	0.0	0.1	0.3	-0.1
Fasting Glucose	0.0	0.1	0.1	-0.3	0.1	-0.2	0.4
Sensitivity / hurt feelings	0.0	0.1	0.2	0.3	0.2	-0.4	0.2
Qualifications: None of the above	0.0	0.1	0.4	-0.6	-0.1	0.3	-0.1
Time employed in main current job	0.0	0.0	0.1	-0.2	-0.2	-0.3	0.1
Medication: Cholesterol lowering	0.0	0.1	0.2	-0.1	-0.5	0.0	-0.2
Breastfed as a baby	0.0	0.0	0.1	0.3	0.1	-0.1	-0.0
High blood pressure (siblings)	0.0	0.0	0.1	0.2	-0.3	-0.1	-0.0
Supplements: Vitamin C	0.0	0.0	0.1	0.2	0.2	0.1	0.3

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