Hub : Genes

STMN3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0730	0.0240	9.8e-05	0.019	0.034	0.044	0.039	0.046	1.9e-03	4.5e-05	4.2e-06	1.2e-05	2.8e-06
2	GTEx	Brain Cerebellar Hemisphere	0.3930	0.1030	5.9e-05	0.076	NA	0.138	NA	0.222	5.3e-03	NA	2.2e-04	NA	2.1e-06
3	GTEx	Brain Cerebellum	0.3310	0.0870	1.4e-05	0.119	NA	0.179	NA	0.197	2.2e-04	NA	5.7e-06	NA	1.8e-06
4	GTEx	Brain Cortex	0.2540	0.0840	1.3e-03	0.093	NA	0.025	NA	0.108	1.6e-03	NA	6.9e-02	NA	6.8e-04
5	GTEx	Cells Transformed fibroblasts	0.2080	0.0570	1.4e-04	0.093	NA	0.130	NA	0.109	1.9e-07	NA	5.9e-10	NA	1.5e-08
6	GTEx	Pituitary	0.4350	0.1060	3.1e-04	0.005	NA	0.064	NA	0.053	2.4e-01	NA	1.1e-02	NA	1.9e-02
7	GTEx	Whole Blood	0.0970	0.0370	2.0e-03	-0.001	NA	-0.003	NA	0.004	4.4e-01	NA	7.0e-01	NA	1.2e-01
8	METSIM	Adipose	0.1966	0.0432	5.5e-12	0.082	0.088	0.114	0.102	0.099	3.0e-12	4.4e-13	1.0e-16	5.7e-15	1.3e-14
9	TCGA	Head and Neck Squamous Cell Carcinoma	0.0226	0.0124	2.6e-03	0.019	0.021	0.015	NA	0.013	2.6e-03	1.7e-03	7.5e-03	NA	1.3e-02
10	TCGA	Ovarian Serous Cystadenocarcinoma	0.0720	0.0400	7.1e-04	0.009	0.046	0.035	NA	0.031	7.3e-02	4.2e-04	2.0e-03	NA	3.2e-03
11	TCGA	Skin Cutaneous Melanoma	0.2440	0.1060	3.1e-03	0.028	0.044	0.097	NA	0.040	6.1e-02	2.5e-02	1.5e-03	NA	3.1e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.4	0.7	1.4	0.5	1.2	1.2	0.6	-0.3	0.7	-0.8	-1.2	0.8	0.9	-0.1
Bipolar Disorder or Schizophrenia	1.4	3.4	8.0	1.2	1.5	2.8	2.5	-1.3	1.1	-1.8	-1.5	2.2	2.4	-0.2
Depressed Affect (Nagel 2018)	0.4	0.9	2.9	-1.4	0.3	0.2	-0.5	-1.1	0.6	-0.6	-0.7	-0.8	-0.9	1.7
Depression (Nagel 2018)	2.3	3.5	5.8	-2.4	-2.4	-2.2	-2.2	0.0	-0.4	2.0	1.5	-2.2	-1.9	1.7
Intelligence (Savage-Jansen 2018)	0.2	0.7	3.7	0.2	0.1	0.9	0.6	1.1	-0.0	-1.9	0.6	0.8	0.4	-0.4
Neuroticism (Nagel 2018)	0.7	1.6	5.1	-1.2	1.0	0.4	-0.2	-1.9	1.3	-0.9	-1.2	-0.9	-1.2	2.3
Schizophrenia (2018)	1.6	3.4	7.4	1.2	1.4	2.7	2.7	-1.1	0.9	-2.5	-1.0	2.2	2.3	-0.1
Schizophrenia vs Biploar Disorder	0.3	0.4	2.5	-0.8	-0.5	0.2	0.2	0.7	0.0	0.0	1.6	-0.3	-0.3	0.1
Worry (Nagel 2018)	0.4	0.9	2.9	0.1	1.2	0.4	-0.4	-1.5	1.1	-0.7	-1.7	-0.6	-0.7	0.8
Alzheimer’s Disease (in mother)	1.0	1.1	2.6	0.3	1.4	1.6	1.4	0.7	1.3	-0.5	-0.7	1.2	1.3	0.2
Alzheimer’s Disease (in father)	0.3	0.4	0.9	-0.5	-0.8	-0.5	-0.6	0.3	-0.6	0.9	0.8	-0.1	-0.5	0.3
Alzheimer’s Disease (including proxy)	0.6	0.9	2.0	0.3	1.0	1.4	1.4	0.0	0.6	-0.1	-0.8	1.4	1.1	0.4
Crohns Disease (2017)	16.5	36.1	62.3	-6.3	-7.9	-7.2	-6.8	-1.4	-6.3	6.5	6.7	-5.7	-4.9	3.4
Irritable Bowel Disease (IBD)	22.2	52.9	100.0	-7.5	-10.0	-8.8	-8.7	-1.0	-7.2	8.3	7.5	-7.0	-5.5	3.8
Ulcerative Colitis (UC)	12.9	24.2	50.4	-4.9	-7.1	-6.0	-6.3	0.8	-4.8	5.6	5.1	-4.5	-3.1	2.3
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.7	1.4	3.5	-1.1	-1.8	-1.5	-1.7	0.5	-0.6	1.9	0.9	-1.0	-0.3	0.3
Verbal and Numeric Reasoning (VNR)	0.8	1.9	5.8	-1.7	-1.9	-1.0	-0.9	0.8	-1.3	-0.3	2.4	-1.2	-1.3	1.0
Breast Cancer	0.4	1.0	2.5	-0.6	-1.6	-1.0	-1.5	1.4	0.2	1.3	0.4	-0.9	-0.5	0.3
Ovarian Cancer	3.1	4.1	7.4	-2.7	-2.7	-2.6	-2.0	0.7	-1.0	1.6	2.0	-1.9	-1.1	2.6
Prostate Cancer	12.6	17.7	31.6	-5.5	-3.2	-5.3	-4.4	1.7	-2.9	3.7	5.6	-4.0	-4.2	4.2
Age at First Birth	1.3	1.9	5.0	1.4	1.0	1.3	1.7	1.6	2.2	-0.5	0.2	1.6	1.0	-1.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.4	0.6	2.8	-1.1	-0.5	0.6	-0.6	-0.7	-0.8	-0.4	0.5	-0.0	-0.1	1.7
Coronary Artery Disease (CAD)	0.2	0.2	1.9	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.3	1.4	0.4
Crohns Disease (2012)	16.6	26.8	37.4	-5.7	-5.8	-5.9	-6.1	-1.4	-5.4	5.8	4.1	-5.9	-5.5	3.0
Mean Putamen Volume	0.1	0.1	0.8	0.3	-0.0	-0.3	0.1	-0.9	0.4	-0.0	-0.5	-0.2	0.2	-0.2
Fasting Glucose	0.5	0.6	2.0	0.6	1.4	0.8	0.5	-1.0	-0.5	-1.0	-0.8	0.0	-0.4	-0.5
HbA1C	0.1	0.1	0.3	0.2	-0.5	-0.2	0.2	0.5	0.3	0.3	-0.5	0.2	0.5	0.3
HDL Cholesterol	2.9	4.9	10.3	3.2	2.8	2.1	2.0	1.9	1.5	-2.4	-1.1	2.0	1.8	-2.7
LDL Cholesterol	1.1	1.7	5.7	1.4	0.2	0.5	2.1	0.7	2.4	-1.5	-0.0	1.4	1.4	-0.3
Lupus	0.2	0.3	1.6	-0.3	-0.7	0.1	-0.3	-0.2	-1.3	0.7	0.5	-0.8	-0.4	-0.2
Neuroticism (2016)	0.2	0.4	0.8	-0.5	0.5	0.1	-0.6	-0.3	0.9	-0.8	-0.5	-0.5	-0.8	0.6
Primary Biliary Cirrhosis	1.4	1.9	5.7	-0.1	-1.9	-1.2	-1.5	-0.0	-1.2	2.4	1.5	-1.2	-0.9	-1.5
Rheumatoid Arthritis	1.7	2.4	5.7	-0.2	-1.2	-1.1	-2.1	-1.5	-2.4	1.9	0.9	-1.7	-1.9	-0.7
Schizophrenia (2014)	1.4	3.0	7.9	0.9	1.2	2.8	2.3	-0.5	1.7	-1.9	-1.0	2.1	2.3	-0.1
Triglycerides	1.2	2.0	7.0	-1.7	-2.6	-1.4	-0.9	-0.4	-0.0	1.0	2.3	-0.8	-1.0	1.1
Type 2 Diabetes (T2D) (2012)	0.3	0.3	2.2	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-1.2	-1.5	0.2
Ulcerative Colitis	13.3	19.2	29.7	-5.3	-5.4	-5.2	-5.2	-0.6	-4.2	4.7	4.1	-4.6	-3.5	3.1
Blood Eosinophil Count	0.6	4.5	17.1	-3.1	-1.9	-1.6	-0.5	-4.1	-1.7	2.0	-0.7	-1.4	-1.3	2.2
Blood Platelet Count	4.1	47.1	72.1	-7.2	-7.2	-8.5	-7.0	-2.5	-6.4	7.7	6.4	-8.0	-8.3	3.7
Blood Red Count	1.5	14.2	23.1	-4.2	-4.7	-4.6	-4.8	0.3	-3.5	2.5	4.5	-4.1	-3.7	1.6
Blood White Count	3.1	22.8	46.3	-6.1	-5.2	-5.5	-4.1	-1.6	-3.5	6.8	4.1	-4.3	-4.2	5.0
Heel T-Score	0.6	4.7	13.2	3.6	1.8	1.8	1.1	3.3	1.4	-2.3	-1.8	0.8	0.6	-2.9
BMI	2.1	12.0	21.4	-1.7	-2.4	-3.6	-4.6	-4.1	-4.6	2.8	0.9	-4.5	-4.6	-0.9
Height	0.5	10.3	36.1	-6.0	-1.9	-2.9	-3.0	1.1	-1.4	3.7	2.3	-1.8	-1.7	5.2
Waist Hip Ratio (WHR)	0.2	1.1	3.1	-1.6	-1.4	-1.8	0.1	-1.3	-0.6	-0.6	0.8	-0.5	-0.6	0.9
Systolic Blood Pressure	2.0	9.9	17.5	-2.6	-4.2	-3.8	-3.6	1.3	-1.9	3.3	2.9	-4.1	-3.8	0.8
Smoking Status	6.6	15.8	26.5	-5.1	-3.8	-4.6	-4.1	-2.5	-3.7	3.8	3.2	-4.3	-3.9	4.1
Allergy or Eczema	12.1	32.0	53.5	-5.7	-5.6	-7.1	-7.3	-2.0	-4.5	6.8	4.7	-6.4	-6.4	3.1
Cardiovascular Disease	2.6	8.5	18.3	-2.3	-4.3	-4.0	-2.9	-0.2	-1.5	3.4	3.2	-3.5	-3.1	0.6
Hypothyroidism (self reported)	0.3	0.7	2.6	-0.0	0.7	0.7	0.1	-0.6	0.5	-1.6	-1.4	-0.3	-0.5	0.9
Respiratory disease	8.9	19.8	32.8	-5.7	-3.5	-4.6	-4.9	-3.8	-3.3	4.3	2.5	-5.5	-5.7	3.9
Type 2 Diabetes (T2D) (2018)	5.0	9.3	18.0	-3.3	-4.2	-3.3	-2.8	-2.0	-3.2	3.2	3.2	-3.0	-2.8	1.9
Lung FEV1/FVC ratio	0.3	1.7	7.4	-0.4	-0.6	-2.0	-2.7	-0.1	-0.5	1.8	-0.3	-1.2	-1.0	-0.8
Lung FVC	11.1	56.4	89.7	9.1	8.9	9.1	7.5	4.6	6.4	-9.5	-6.7	7.6	7.1	-4.0
Neuroticism	1.1	2.6	6.9	-1.7	0.9	-0.3	-1.2	-2.6	0.8	-0.4	-1.5	-1.6	-2.2	2.5
Chronotype (morning person)	0.4	0.9	4.5	-0.4	-1.3	-0.9	-0.8	0.6	-2.1	-0.5	0.7	-0.7	-0.4	0.9
Hair Pigment	0.4	10.8	20.1	-4.5	-2.7	-3.9	-3.4	-3.2	-3.3	2.7	1.8	-3.1	-2.8	4.0
Tanning	0.1	1.6	6.0	1.2	2.4	1.4	0.8	0.4	-1.2	-1.4	-1.4	0.1	-0.4	-1.4
Hand grip strength (left)	0.3	0.8	2.6	-1.3	-1.4	-0.5	-0.0	0.6	0.9	-0.1	1.1	-0.4	-0.4	1.6
Number of treatments/medications taken	1.4	2.5	5.2	-1.5	-2.1	-1.7	-2.3	-1.1	-1.3	1.4	0.5	-2.1	-2.0	0.3
Average weekly spirits intake	0.6	0.7	3.1	-0.4	0.1	-0.3	-0.6	-1.8	0.5	0.3	-0.6	-1.2	-1.4	-0.5
Sensitivity / hurt feelings	0.4	0.6	2.6	-0.7	-0.7	0.1	0.3	-0.5	1.4	-0.5	0.9	-0.1	-0.5	1.6
Frequency of depressed mood in last 2 weeks	1.5	2.1	3.6	-1.9	-1.8	-1.4	-1.6	0.0	0.3	1.8	1.5	-1.4	-1.2	1.6
Hearing difficulty/problems: Yes	0.3	0.4	0.9	-0.8	0.8	-0.1	-0.2	-1.0	0.8	-0.4	-0.6	-0.3	-0.6	1.0
Relative age of first facial hair	1.6	3.2	5.6	-1.7	-1.8	-1.9	-1.9	-0.7	-1.1	2.3	1.7	-2.4	-1.9	1.8
Other serious medical condition/disability diagnosed by doctor	3.0	3.9	7.4	-1.8	-1.6	-1.8	-2.4	-2.0	-2.7	1.3	1.1	-2.6	-2.7	0.8
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.9	-0.3	0.3	-0.2	-0.4	-0.5	0.7	-0.0	-1.4	-0.5	-0.6	0.4
Ever had hysterectomy (womb removed)	0.4	0.4	1.5	-0.6	-0.1	-0.7	-0.4	-0.0	1.2	-0.2	0.2	-0.8	-0.8	0.8
Systolic blood pressure, automated reading	4.4	12.7	21.6	-3.4	-3.9	-4.6	-4.4	-0.5	-3.1	2.9	2.7	-4.6	-4.6	1.8
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.4	-0.6	-0.9	-1.1	-0.8	-0.7	0.1	1.2	-0.0	-0.9	-1.1	0.5
Angina	0.7	0.9	1.9	0.0	-1.2	-0.5	-0.6	-1.4	-1.3	0.5	0.8	-1.2	-1.2	-0.4
Medication for hormone replacement therapy	1.0	1.1	3.7	0.5	1.5	1.4	0.3	0.8	0.9	-1.9	-1.4	0.8	0.2	0.4
Vitamin and mineral supplements	0.5	0.6	3.2	0.5	0.6	0.4	0.3	-1.8	-0.5	0.0	-1.1	0.3	0.5	-0.9
Supplements: Zinc	0.5	0.6	3.7	0.1	0.1	-1.1	0.0	-0.6	1.9	0.5	-0.4	-0.6	-0.5	0.0
Medication: Co-codamol	1.4	1.6	2.7	-1.5	-1.3	-1.1	-1.4	-1.2	-1.3	0.7	1.1	-1.7	-1.4	0.8
Medication: Metformin	2.5	3.5	10.8	-2.1	-3.3	-2.1	-0.8	-0.9	-1.4	1.8	2.0	-1.7	-1.4	1.9
Diabetes (father)	1.7	2.1	7.4	-0.8	-0.9	-1.4	-1.1	-1.5	-1.6	0.8	0.4	-2.2	-2.7	-0.5
Diabetes (mother)	1.0	1.2	2.2	-1.4	-1.5	-1.1	-1.2	-0.4	-1.1	0.8	0.2	-1.3	-1.1	1.4
Severe depression (siblings)	2.3	2.6	5.5	-1.9	-1.4	-2.2	-1.6	-1.1	-0.6	1.7	0.6	-2.1	-2.3	0.9
Pack years adult smoking proportion	4.2	6.4	14.8	-1.3	-3.9	-3.2	-2.8	-1.1	-2.8	3.2	2.8	-2.2	-1.8	-0.5
Impedance of leg (right)	0.4	1.8	5.1	-1.9	-2.3	-1.5	-0.2	0.1	-1.3	1.5	1.8	-0.3	0.4	1.0
Leg fat-free mass (left)	0.3	1.7	4.5	-1.2	-0.4	-1.0	-2.0	-1.4	-0.9	1.3	0.5	-1.7	-2.1	0.2
Trunk fat percentage	2.7	11.0	19.3	-2.5	-3.0	-3.8	-3.9	-4.4	-3.9	3.5	1.4	-3.8	-3.5	-0.8
Hand grip strength (right)	0.4	1.2	3.2	-1.4	-1.5	-0.5	-0.2	1.3	1.7	0.1	0.9	-0.3	-0.4	1.8
Townsend deprivation index at recruitment	0.3	0.4	0.9	-0.6	-0.5	-1.0	-0.2	-0.8	0.7	0.9	-0.9	-0.4	-0.1	0.6
Current tobacco smoking	8.4	13.7	26.8	-4.5	-5.2	-4.4	-4.4	-0.5	-2.6	4.1	3.6	-3.7	-3.0	2.4
Average weekly fortified wine intake	0.6	0.7	2.5	0.6	0.1	0.9	1.2	-1.1	0.4	-0.2	-1.6	0.7	0.6	-0.1
Maternal smoking around birth	2.5	3.7	8.0	-1.6	-1.7	-2.3	-2.4	-1.3	-2.0	1.2	0.9	-2.8	-2.8	0.5
Fed-up feelings	0.6	1.2	2.6	-1.5	-0.7	-0.4	-1.0	-1.6	-0.2	-0.1	0.4	-1.3	-1.3	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	4.4	5.9	10.8	-2.8	-3.3	-3.0	-2.5	0.6	-0.7	2.4	3.1	-2.8	-2.1	1.7
Relative age voice broke	0.8	1.2	2.8	-0.8	-0.8	-1.5	-0.7	-0.7	-0.5	0.9	1.1	-1.5	-1.7	1.1
Taking other prescription medications	2.9	4.4	8.4	-2.0	-2.3	-1.8	-2.5	-2.9	-1.7	1.7	0.3	-2.6	-2.8	0.9
Age when periods started (menarche)	0.3	0.8	5.0	0.0	-0.4	-0.4	0.6	2.2	1.0	0.7	0.5	0.7	0.9	0.5
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	4.1	-1.4	-1.6	-2.0	-1.2	0.4	0.6	-0.0	1.4	-1.9	-1.7	2.0
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.5	0.9	-0.4	-0.8	-1.0	-0.2	-0.5	0.5	0.4	-1.8	-1.9	-1.4
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	4.8	1.2	1.4	1.2	1.2	0.1	2.2	-0.4	-1.6	1.1	0.6	-1.2
Qualifications: CSEs or equivalent	4.0	5.3	10.1	-2.6	-2.2	-2.5	-1.8	-1.6	-1.3	3.2	1.7	-2.9	-2.7	2.0
Serious illness, injury or assault to yourself	1.0	1.2	3.9	-1.2	-2.0	-0.6	-0.4	-1.0	-0.6	0.9	2.0	-0.5	-0.6	0.8
High blood pressure	1.9	5.2	9.9	-2.2	-3.0	-2.8	-2.5	0.4	-1.2	1.6	2.3	-3.1	-3.0	1.1
Hayfever, allergic rhinitis or eczema	11.4	24.7	38.0	-4.9	-5.2	-6.1	-6.2	-1.3	-4.4	6.0	4.6	-5.4	-5.4	3.0
Multivitamins +/- minerals	0.2	0.3	1.3	-0.2	-0.2	0.2	0.1	1.1	1.0	-0.1	0.5	0.2	0.3	0.7
Stomach or abdominal pain in last month	0.3	0.3	1.5	0.8	0.8	0.8	0.3	-0.0	-0.1	-0.1	-0.4	0.1	-0.3	-1.2
Supplements: Glucosamine	1.1	1.4	3.2	-0.9	-0.7	-1.4	-1.8	0.4	-0.9	1.2	0.8	-1.8	-1.8	-0.2
Diverticular disease/diverticulitis (self-reported)	3.6	4.3	9.3	1.9	2.1	3.0	1.9	1.5	2.3	-0.9	-0.9	2.9	2.7	-1.5
Medication: Atenolol	0.9	1.2	3.1	-0.9	-1.3	-1.3	-0.7	-0.5	-0.5	0.8	1.1	-1.8	-1.5	0.3
Medication: Levothyroxine sodium	0.1	0.2	1.1	-0.2	-0.5	-0.1	-0.6	-0.2	-0.1	-0.6	0.4	-0.1	-0.1	1.0
Sitting height	0.6	4.1	10.0	0.5	2.2	2.5	1.9	3.0	3.2	-0.7	-1.3	2.3	1.9	0.6
Chronic bronchitis/emphysema (father)	2.8	3.2	6.6	-2.4	-2.2	-1.6	-1.8	-2.6	-1.5	1.5	1.5	-1.6	-1.3	1.4
High blood pressure (mother)	1.5	2.0	5.6	-1.3	-1.8	-1.9	-1.5	0.0	-1.1	2.4	1.0	-1.5	-0.9	0.8
Body mass index (BMI)	1.7	7.4	14.5	-1.4	-2.1	-2.9	-3.8	-3.5	-3.6	1.8	0.6	-3.3	-3.4	-0.9
Impedance of leg (left)	0.5	2.4	6.1	-2.1	-2.5	-2.1	-0.7	0.2	-1.2	2.2	1.9	-0.8	-0.0	0.9
Leg predicted mass (left)	0.3	1.7	4.3	-1.2	-0.4	-1.0	-2.0	-1.4	-0.9	1.3	0.4	-1.6	-2.1	0.1
Trunk fat mass	2.3	10.1	16.8	-2.7	-2.7	-3.6	-4.1	-3.9	-3.6	3.2	1.2	-3.7	-3.6	-0.5
Waist circumference	2.7	10.0	16.4	-2.7	-2.6	-3.7	-4.0	-4.0	-3.8	2.3	1.1	-3.7	-3.9	0.1
Number of incorrect matches in round	3.3	5.5	11.0	2.7	3.2	2.6	2.1	0.1	2.2	-2.4	-3.3	2.1	1.8	-1.7
Past tobacco smoking	0.8	1.4	4.1	1.3	-0.4	0.9	0.9	2.0	1.9	-0.2	0.0	0.9	0.9	-1.7
Alcohol usually taken with meals	0.3	0.5	2.2	0.8	1.4	0.5	-0.1	0.0	-0.5	0.0	-1.5	-0.3	-0.4	-0.3
Nervous feelings	0.6	1.0	4.4	0.7	0.8	0.7	0.5	-1.3	2.1	-1.4	-1.1	0.3	0.2	0.0
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.2	6.5	-2.0	-1.8	-1.8	-2.6	-0.9	-0.8	2.3	1.2	-2.4	-1.7	1.1
Hearing difficulty/problems with background noise	0.5	0.9	1.8	-1.2	-0.3	-1.1	-1.1	-0.4	0.5	0.4	0.1	-1.2	-1.1	1.3
Hair/balding pattern: Pattern 2	3.7	4.7	7.6	-2.2	-2.8	-2.5	-2.2	-0.4	-1.9	2.7	2.5	-1.9	-2.1	1.5
Had menopause	1.4	1.7	6.3	-1.8	-0.9	-1.4	-2.5	0.5	0.5	1.2	0.1	-1.3	-1.1	1.3
Had other major operations	0.8	0.9	3.0	-1.1	-0.7	-1.0	-1.0	-1.7	-0.4	0.7	0.3	-1.1	-1.2	0.6
Forced vital capacity (FVC)	6.7	25.9	38.3	5.0	5.9	6.0	5.7	4.1	5.0	-6.2	-4.3	5.5	5.2	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	3.2	0.1	-0.8	-1.1	-1.3	0.8	-0.2	0.5	0.9	-1.5	-1.8	-0.2
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.9	-1.5	-1.0	-0.1	-0.9	-1.7	-1.4	0.8	0.9	-1.1	-1.4	1.1
Qualifications: None of the above	0.3	0.7	1.7	0.9	0.1	0.6	-0.2	-1.3	-1.0	-0.4	-1.2	0.5	0.9	-1.2
Financial difficulties in last 2 years	2.4	3.2	6.0	-2.4	-1.4	-2.0	-1.9	-1.7	-1.3	1.4	1.1	-1.9	-2.0	2.1
Mouth/teeth dental problems	1.3	2.0	9.2	0.9	0.8	1.4	0.9	2.0	3.0	-1.0	0.0	1.3	1.2	-0.4
Heart attack	0.3	0.4	1.0	1.0	0.1	0.9	0.8	-0.7	0.5	-0.9	-0.0	0.3	0.2	-0.6
Allergy	13.2	30.4	45.4	5.9	5.0	6.1	6.6	2.4	4.9	-6.7	-4.6	6.4	6.5	-3.7
Pain all over the body in last month	3.0	3.2	5.8	-1.4	-2.0	-1.8	-2.4	-1.1	-1.9	2.3	0.5	-2.3	-2.0	-1.1
Diabetes (self-reported)	3.5	5.4	15.4	-2.3	-3.9	-2.5	-1.9	-1.4	-2.8	2.0	2.5	-2.0	-1.8	1.4
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	4.5	-2.1	-1.8	-1.4	-1.7	-0.4	-0.3	1.4	1.4	-0.7	-0.9	1.5
Medication: Ramipril	2.8	3.6	12.9	-2.0	-3.6	-2.0	-2.1	0.1	-0.3	1.8	1.5	-2.2	-1.7	1.1
Medication: Simvastatin	0.3	0.4	2.3	-0.6	-1.5	-0.5	0.2	-0.8	-0.1	-0.0	0.5	0.0	0.1	0.6
Fluid intelligence score	0.4	0.8	6.4	-0.2	-0.4	-0.0	-0.3	2.5	-0.2	-0.8	1.1	0.2	0.2	-0.2
Illnesses of siblings	0.6	0.9	3.7	1.0	0.5	0.3	0.1	1.9	-0.5	-0.0	1.1	0.8	1.1	-1.1
Neuroticism score	0.6	1.2	3.1	-1.2	0.7	0.4	-0.5	-1.7	1.4	-0.8	-1.1	-0.6	-0.9	1.6
Weight	1.4	6.8	14.6	-2.5	-1.9	-2.8	-3.8	-2.6	-2.8	2.6	0.7	-3.1	-3.2	0.1
Impedance of arm (right)	0.3	1.4	7.7	0.5	-0.3	0.4	2.8	-0.3	0.2	0.6	0.3	1.6	2.0	-0.6
Arm fat percentage (right)	2.3	9.2	18.0	-1.7	-2.8	-3.4	-3.2	-4.2	-3.9	2.6	1.0	-3.6	-3.6	-1.2
Trunk fat-free mass	0.2	1.3	4.6	-1.5	0.1	-0.8	-2.1	0.1	-0.4	0.6	-0.0	-1.4	-2.0	0.9
Hip circumference	2.8	12.1	25.1	-2.7	-2.3	-3.7	-5.0	-3.7	-4.2	3.2	1.5	-4.3	-4.5	-0.1
Time employed in main current job	0.5	0.5	2.6	0.3	1.1	0.5	0.1	-0.3	1.1	-0.3	-1.6	0.2	0.5	-0.0
Alcohol intake versus 10 years previously	0.7	1.0	2.1	-1.0	0.1	-1.3	-1.4	0.6	-0.5	1.4	-0.8	-1.2	-0.9	0.9
Father’s age at death	0.4	0.5	2.0	-0.7	0.6	-0.4	-0.1	1.3	0.7	-0.6	-0.4	0.1	0.2	1.4
Worrier / anxious feelings	0.7	1.4	2.5	-1.5	-0.5	-0.5	-1.3	-1.6	0.9	0.8	-1.0	-1.6	-1.3	1.4
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.6	8.1	-2.0	-2.8	-1.9	-2.2	-1.7	-1.3	2.7	0.6	-2.0	-1.4	0.7
Falls in the last year	0.6	0.8	4.5	-0.6	-0.2	-0.3	-0.6	-2.1	0.1	0.5	-0.7	-0.9	-1.2	-0.3
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	0.0	0.4	-0.1	-0.7	-0.6	-0.9	-0.5	-0.6	-0.7	-0.7	-0.7
Number of live births	1.0	1.4	3.8	-0.4	-1.7	-1.6	-0.7	-0.9	-1.4	0.9	1.9	-0.8	-0.8	-0.7
Forced expiratory volume in 1-second (FEV1)	4.9	16.5	21.6	4.2	4.5	4.5	4.1	4.0	4.5	-4.6	-3.3	4.4	4.0	-1.2
Pulse rate	0.5	0.8	2.4	0.6	-1.2	-1.2	-0.9	0.7	-1.1	-0.1	0.4	-0.3	-0.3	-1.5
Happiness	0.5	0.6	2.5	0.2	-0.4	-0.2	-0.7	-1.0	-0.6	0.5	0.5	-1.1	-1.6	-0.8
Noisy workplace	1.3	1.6	5.1	-1.2	-2.2	-1.5	-1.2	-0.1	-0.6	1.4	0.7	-1.5	-1.3	1.0
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.5	0.9	0.5	-0.5	0.5	-0.5	-1.2	-0.4	1.2	-0.1	-0.5	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.4	-0.8	-0.6	0.5	0.3	0.2	-0.2	-0.2	1.6	0.9	1.4	0.7
Mouth/teeth dental problems: Dentures	3.0	5.0	14.1	-1.9	-2.2	-2.3	-2.6	-2.2	-3.8	1.8	0.4	-2.7	-2.2	0.4
Asthma	8.5	16.7	32.3	-4.9	-3.0	-4.4	-4.4	-3.0	-3.2	3.6	2.9	-5.2	-5.7	3.4
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.6	0.3	0.4	0.5	-0.1	-0.2	-0.3	0.4	-0.8	-0.4	-0.6	-0.5
Medication: Cholesterol lowering	0.3	0.5	1.6	0.1	-1.1	-1.0	0.2	-1.2	0.4	0.5	0.3	-0.7	-0.8	-0.4
Depression (self-reported)	2.1	2.6	7.4	2.4	0.1	1.7	1.4	1.4	1.1	-1.4	-0.8	1.3	1.7	-2.7
Medication: Lansoprazole	0.6	0.6	1.7	-1.3	-1.2	-0.8	-0.6	-0.5	0.1	1.0	0.2	-0.6	-0.7	0.7
Prospective memory result	0.5	0.6	2.0	0.0	-0.4	1.0	1.0	0.2	0.3	-0.9	0.4	1.2	1.4	0.5
Lung cancer (father)	0.8	0.9	2.5	-1.0	-0.2	-0.9	-1.6	0.1	-0.8	0.5	0.8	-1.3	-1.5	0.2
Illnesses of mother	2.4	3.0	5.4	2.0	2.1	2.3	1.9	0.6	1.5	-1.9	-1.2	1.8	1.6	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	4.1	13.0	19.2	3.6	4.2	3.9	3.7	3.5	3.7	-4.4	-3.2	3.7	3.5	-0.7
Pulse wave Arterial Stiffness index	0.2	0.2	0.6	-0.3	0.6	-0.6	-0.2	-0.7	-0.1	0.1	-0.4	0.3	0.3	0.8
Impedance of arm (left)	0.4	1.7	7.9	0.7	-0.1	0.7	2.8	-0.1	1.0	0.3	0.3	1.8	2.2	-0.5
Arm fat mass (right)	2.3	9.3	15.3	-2.0	-2.4	-3.3	-3.9	-3.9	-3.8	2.6	0.8	-3.7	-3.9	-0.9
Trunk predicted mass	0.2	1.4	4.8	-1.5	-0.0	-0.8	-2.2	0.1	-0.4	0.7	0.0	-1.4	-2.0	0.9
Standing height	0.2	1.8	6.3	-2.5	0.1	-0.4	-0.6	1.7	1.0	2.0	0.6	-0.0	-0.4	2.2
Length of working week for main job	0.6	0.7	4.6	-0.2	0.5	0.7	-0.0	2.2	1.4	0.1	0.1	0.2	0.5	0.0
Exposure to tobacco smoke at home	0.3	0.4	1.8	0.5	0.3	0.0	-0.1	-1.3	-0.2	-1.0	-0.4	-0.0	0.5	-0.9
Breastfed as a baby	0.5	0.6	1.4	-0.4	-0.5	-0.9	-0.3	-1.2	-1.2	0.9	1.1	-0.2	-0.7	0.5
Tense / ‘highly strung’	0.4	0.7	1.4	-0.3	0.7	-0.1	-0.9	-1.1	1.1	0.6	-0.9	-1.2	-1.1	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	3.8	5.8	14.9	-1.9	-3.9	-2.9	-2.9	0.5	-1.2	2.0	3.1	-2.5	-2.3	1.0
Hair/balding pattern: Pattern 4	0.2	0.5	2.3	-0.3	1.1	-0.2	-0.6	-0.6	-0.8	0.0	-1.5	-0.8	-0.1	0.3
Birth weight of first child	0.2	0.3	1.0	-0.5	0.9	-0.2	-0.5	-0.9	-1.0	-0.0	0.1	-0.1	-0.5	0.1
Peak expiratory flow (PEF)	0.3	0.6	4.4	1.0	0.4	0.1	0.3	2.1	1.0	-0.2	-0.4	0.3	0.1	-0.5
Pulse wave reflection index	0.5	0.7	2.3	0.2	1.5	-0.1	0.2	-1.1	0.3	-0.5	-1.5	0.1	0.2	0.9
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.3	-0.3	-0.7	0.1	0.1	-1.1	-0.6	0.4	-0.1	-0.9	-1.1	0.1
Loud music exposure frequency	0.6	0.7	1.5	0.1	0.9	1.2	0.9	-0.4	0.9	0.3	-1.0	-0.6	-1.1	-0.6
Qualifications: O levels/GCSEs or equivalent	1.5	2.3	5.4	-1.7	-1.6	-1.2	-1.0	-0.5	-1.1	1.2	1.9	-1.8	-2.3	1.6
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	1.3	-0.2	1.0	-0.4	0.6	-0.6	0.2	-0.1	-0.2	0.4	0.3	1.1
Blood clot in the leg (DVT)	0.1	0.1	0.4	0.0	0.1	0.6	-0.3	-0.2	-0.6	0.2	0.4	0.2	0.1	-0.6
Medication: Paracetamol	0.4	0.6	1.5	0.9	0.5	-0.2	-1.2	0.5	-1.1	-0.2	-0.1	-0.8	-0.5	-1.2
Headache pain in last month	0.2	0.3	0.9	0.3	0.3	0.4	-0.8	0.4	-0.5	0.7	-0.3	0.1	-0.3	-1.0
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.7	0.2	1.6	1.0	0.4	0.9	-0.4	-0.2	-0.6	1.1	0.9	0.2
Glaucoma (self-reported)	0.7	0.8	4.2	0.5	1.1	-0.4	-0.1	-2.0	-0.6	0.3	-0.8	-0.7	-0.9	-0.5
Gout (self-reported)	1.4	2.0	3.3	0.9	1.5	1.5	1.3	1.6	1.5	-1.6	-1.8	1.4	1.4	-0.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.6	-0.2	0.3	0.2	-0.4	-0.6	0.5	-1.3	-1.0	-0.3	-0.1	1.0
Medication: Amlodipine	0.5	0.7	3.4	-1.3	-0.5	-0.2	-1.0	0.2	0.1	-0.1	0.6	-0.6	-0.8	1.8
Medication: Ventolin 100micrograms inhaler	3.6	4.6	10.4	-3.2	-2.6	-2.2	-2.2	0.1	-1.6	1.9	1.9	-1.7	-2.0	2.6
Birth weight	0.1	0.2	0.4	0.1	0.6	-0.0	0.5	-0.4	-0.6	-0.4	0.3	0.6	0.6	0.3
Chronic bronchitis/emphysema (mother)	1.8	2.1	4.0	-1.2	-2.0	-1.2	-1.0	-1.9	-1.7	0.7	1.1	-1.7	-1.9	0.0
High blood pressure (siblings)	0.6	0.9	3.1	0.1	0.8	0.9	1.0	-1.8	-0.2	-1.4	-1.3	0.0	-0.3	-0.0
Forced vital capacity (FVC), Best measure	5.0	18.3	29.8	4.0	5.3	5.0	4.6	3.5	4.0	-5.5	-3.9	4.4	4.1	-0.6
Body fat percentage	3.4	13.3	20.3	-2.9	-3.6	-4.3	-4.4	-4.5	-4.3	3.5	1.7	-4.1	-3.9	-0.5
Leg fat percentage (right)	4.0	14.4	22.8	-3.2	-3.7	-4.4	-4.7	-4.5	-4.8	3.1	1.7	-4.4	-4.2	-0.1
Arm fat-free mass (right)	0.8	4.1	13.2	-2.4	-1.1	-2.0	-3.6	-0.3	-1.3	1.6	0.8	-2.6	-2.8	1.3
Exposure to tobacco smoke outside home	1.3	1.8	4.8	-1.8	-1.7	-1.4	-0.9	0.1	-1.2	0.1	2.2	-0.7	-0.6	1.9
Comparative body size at age 10	0.3	1.0	3.5	0.8	0.7	0.9	0.5	0.8	-0.5	-0.3	-1.1	1.1	1.9	-1.3
Number of full brothers	0.2	0.2	0.8	-0.7	-0.4	-0.1	0.5	-0.9	-0.1	-0.8	0.1	0.1	-0.2	0.4
Worry too long after embarrassment	0.8	1.3	3.1	0.6	1.7	1.4	0.6	-1.0	1.3	-1.7	-1.7	0.5	0.1	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	3.2	0.9	-1.0	-0.1	0.2	0.6	0.8	-0.2	-0.1	-0.2	0.3	-1.8
Wheeze or whistling in the chest in last year	12.1	21.6	32.1	-5.4	-3.7	-5.1	-5.7	-4.6	-4.7	4.4	2.6	-5.5	-5.3	3.0
Number of children fathered	0.2	0.3	1.1	0.4	-0.2	0.0	-0.1	-0.6	-0.7	0.2	-0.4	-0.3	-1.0	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.5	1.6	0.5	0.8	0.6	1.1	-0.1	-0.9	0.1	0.7	0.6	-1.2
Age at first live birth	2.4	4.3	8.9	2.0	2.6	3.0	2.4	0.9	1.8	-2.3	-1.7	2.4	1.8	-0.9
Pulse wave peak to peak time	0.2	0.2	0.6	-0.0	-0.7	0.5	0.2	0.8	0.3	0.1	0.6	-0.4	-0.5	-0.4
Health satisfaction	1.2	1.6	6.6	0.1	-1.2	-0.9	-0.8	-2.6	-1.9	0.6	0.9	-0.8	-1.0	-1.1
Shortness of breath walking on level ground	0.9	1.0	4.1	-0.2	-1.0	0.1	-0.3	-2.0	-0.6	0.8	-1.7	-1.0	-0.9	-0.7
Qualifications: College or University degree	3.9	12.4	20.3	3.5	4.5	4.5	4.1	1.3	2.6	-3.8	-3.2	4.2	3.7	-1.7
Eye problems/disorders: None of the above	0.8	0.9	2.1	-0.4	-0.1	-1.0	-1.1	-1.3	-1.0	1.0	-0.6	-1.2	-1.4	-0.1
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.7	-0.1	-0.2	-0.1	0.1	-1.6	-0.5	0.7	-1.0	-0.8	-0.7	-0.9
Emphysema/chronic bronchitis	3.3	3.7	7.2	-2.7	-2.0	-2.0	-1.7	-2.1	-1.7	2.6	1.3	-1.4	-1.1	2.0
Medication for pain relief, constipation, heartburn	2.5	4.2	9.6	0.6	2.1	2.2	3.1	1.1	2.0	-2.3	-1.0	2.7	2.8	0.8
Neck or shoulder pain in last month	0.3	0.4	1.1	0.1	-0.5	-0.5	-0.6	-1.1	-1.0	-0.3	-0.9	-0.5	-0.6	-0.4
Medication: Blood pressure	0.3	0.6	2.0	-0.6	-1.4	-0.6	-0.9	-0.1	-0.4	-0.1	0.9	-1.0	-0.8	0.2
Angina (self-reported)	0.7	0.9	1.8	-0.2	-1.2	-0.6	-0.7	-1.3	-1.4	0.5	0.7	-1.3	-1.2	-0.1
Migraine (self-reported)	1.4	1.8	3.8	-1.2	-1.4	-1.4	-1.9	-0.8	-0.3	1.7	-0.0	-1.6	-2.0	0.4
Medication: Ibuprofen	1.0	1.2	2.3	1.2	1.0	1.5	1.0	0.5	1.4	-0.7	-1.4	0.9	0.7	-1.5
Medication: Allopurinol	1.5	2.0	4.7	1.4	2.2	1.7	1.0	0.4	1.3	-1.6	-2.1	1.1	0.9	-0.9
Medication: Omeprazole	2.1	2.6	7.1	-1.3	-0.8	-1.8	-1.7	-2.2	-1.3	2.7	0.1	-1.8	-1.7	-0.3
Medication: Seretide 50 evohaler	1.2	1.3	3.8	-1.3	-0.1	-0.9	-1.5	-2.0	-1.0	1.1	0.3	-1.4	-1.1	1.0
Mean time to correctly identify matches	0.4	0.7	2.1	-0.6	-1.0	-1.3	-1.4	-0.1	0.0	1.2	0.4	-0.9	-0.2	-0.0
Heart disease (mother)	0.8	1.0	3.0	-0.7	-1.0	-1.2	-0.8	-1.7	-1.0	0.6	0.2	-1.2	-1.0	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.3	5.1	9.5	-1.5	-2.8	-2.7	-2.7	-1.8	-3.1	1.8	0.7	-3.0	-2.4	0.6
Whole body fat mass	2.9	12.3	21.9	-3.2	-3.2	-4.1	-4.7	-3.7	-4.0	3.3	1.6	-4.1	-4.0	0.1
Leg fat mass (right)	2.8	10.8	18.8	-2.8	-3.1	-3.6	-4.3	-3.7	-4.0	2.7	1.5	-3.9	-3.8	-0.0
Arm predicted mass (right)	0.8	3.9	12.8	-2.3	-0.9	-1.9	-3.6	-0.4	-1.2	1.6	0.7	-2.6	-2.8	1.0
Pulse rate, automated reading	1.5	4.7	9.0	-1.7	-2.6	-2.8	-3.0	-0.2	-3.0	2.3	2.7	-1.6	-1.1	-0.1
Alcohol intake frequency.	0.2	0.4	1.6	0.2	-0.1	-0.0	-0.5	0.6	-0.1	1.3	-0.8	-0.1	0.3	-1.1
Comparative height size at age 10	0.4	2.4	4.7	0.4	1.5	2.2	1.5	1.6	1.4	-1.4	-1.5	2.1	2.0	-0.7
Number of full sisters	0.2	0.2	0.6	-0.5	-0.8	-0.5	-0.2	-0.3	-0.4	-0.4	0.7	-0.3	-0.5	0.1
Suffer from ‘nerves’	0.2	0.3	1.4	-0.2	0.2	-0.0	-0.2	-1.1	1.2	0.4	0.3	0.1	0.1	0.6
Overall health rating	1.7	3.7	11.4	-1.3	-2.2	-1.7	-1.9	-3.4	-3.1	1.1	0.7	-1.7	-1.4	-0.2
Chest pain or discomfort	1.4	2.0	13.3	-0.6	-0.7	-0.0	-0.2	-3.6	-1.6	0.2	0.4	-1.2	-1.9	-0.1
Had major operations	0.6	0.7	2.9	0.7	0.2	1.2	0.8	0.2	0.7	-0.9	-1.7	0.8	0.7	-0.5
Age at last live birth	0.8	1.1	2.1	1.3	1.2	1.3	1.1	1.4	1.2	-0.4	-0.5	0.9	0.6	-1.1
Family relationship satisfaction	0.4	0.5	2.1	-0.4	-0.3	-0.1	-0.3	-1.3	-0.5	0.3	0.1	-1.0	-1.4	-0.3
Leg pain on walking	0.6	0.8	1.9	-0.1	-1.4	-0.9	-0.7	-0.3	-0.8	1.1	0.3	-1.0	-1.3	-0.8
Qualifications: NVQ or HND or HNC or equivalent	4.0	4.9	8.2	-2.8	-2.0	-2.9	-2.5	-1.1	-0.9	2.6	2.1	-2.0	-1.8	2.6
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.7	-0.0	-0.5	0.6	-0.3	-0.6	-1.1	0.2	-1.3	-0.4	-0.5	-0.8
Illness, injury, bereavement, stress in last 2 years	4.0	4.9	8.6	2.9	2.0	2.2	1.9	2.1	1.3	-2.3	-2.8	1.9	2.2	-2.4
Medication: Aspirin	1.8	2.3	7.3	-0.8	-2.7	-1.8	-1.4	-0.5	-0.7	2.0	1.4	-1.8	-1.7	-0.3
Supplements: Vitamin C	0.7	0.8	2.9	-1.3	-0.3	-0.9	-0.4	0.5	0.0	-0.2	1.4	-0.7	-1.0	1.7
Knee pain experienced in last month	0.9	1.4	3.7	-1.2	-0.8	-1.0	-1.4	-1.9	-1.7	0.4	0.4	-1.2	-1.5	0.3
Hypertension (Self-reported)	1.8	5.1	10.3	-2.2	-2.7	-2.7	-2.6	0.0	-1.4	1.6	2.1	-3.2	-3.0	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.0	-0.3	-0.9	-0.9	-0.8	0.1	-0.7	0.7	1.0	-0.7	-1.0	-0.4
Illnesses of father: Heart disease	0.2	0.2	0.8	-0.1	-0.2	0.6	0.8	-0.1	0.5	-0.3	-0.0	0.3	0.4	0.9
Illnesses of siblings: Diabetes	4.9	6.0	9.8	-2.6	-2.4	-3.1	-2.3	-2.7	-1.7	2.1	1.0	-2.9	-3.1	2.1
Smoking status: Previous	0.9	1.3	4.6	-0.5	1.8	0.3	0.2	-2.2	-1.0	-1.0	-1.2	-0.1	-0.2	1.6
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.6	7.6	-1.8	-2.3	-1.4	-1.0	1.6	-0.2	1.7	2.8	-0.6	-0.4	1.7
Whole body fat-free mass	0.3	1.7	5.5	-1.5	-0.2	-1.1	-2.3	-0.5	-0.7	1.0	0.2	-1.7	-2.2	0.7
Leg fat-free mass (right)	0.3	1.5	4.5	-1.0	-0.2	-1.0	-1.9	-0.9	-0.5	1.4	0.3	-1.7	-2.1	0.0
Arm fat percentage (left)	2.1	8.5	17.4	-1.6	-2.7	-3.3	-3.2	-4.2	-3.7	2.4	1.0	-3.4	-3.4	-1.2
Average weekly red wine intake	0.5	0.7	2.0	-0.1	0.5	0.0	-0.4	-1.3	-0.5	-0.2	-1.3	-1.4	-1.3	-0.2
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.1	-0.8	-0.1	-0.6	-0.6	-0.9	-0.2	0.7	0.5	-0.4	-0.6	1.1
Mood swings	0.5	0.8	3.4	-1.8	-0.5	0.2	-0.7	-1.3	-0.0	0.4	0.3	-0.7	-0.9	1.4
Loneliness, isolation	0.9	1.2	2.5	-1.6	-1.1	-0.9	-0.9	-1.3	0.9	1.1	-0.3	-1.1	-1.0	1.3
Long-standing illness, disability or infirmity	4.2	6.5	12.4	-2.4	-3.1	-2.3	-2.6	-3.3	-3.5	1.7	1.6	-2.7	-2.6	0.6
Ever had bowel cancer screening	0.5	0.5	1.0	-0.9	0.3	-0.8	-0.7	-0.5	-0.4	0.6	-1.0	-0.9	-0.9	0.7
Diabetes diagnosed by doctor	3.3	5.4	10.6	-2.4	-3.3	-2.5	-1.6	-2.5	-2.6	1.9	2.0	-2.4	-2.3	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.8	-0.2	0.2	-0.1	0.1	1.3	0.6	0.7	0.2	-0.1	-0.4	-0.6
Friendships satisfaction	0.9	1.1	4.1	1.2	0.5	0.2	0.2	-1.4	0.3	0.5	-0.6	-0.9	-1.7	-2.0
Qualifications: nursing, teaching	0.3	0.5	1.6	0.6	-0.8	-0.7	0.0	0.7	1.3	0.6	1.2	-0.2	-0.3	-0.4
Commuting to job workplace: Walk	1.2	1.3	3.5	-0.8	-1.3	-1.9	-0.9	-0.4	-0.5	1.3	1.3	-1.4	-1.0	0.5
Eye problems/disorders: Cataract	2.1	2.4	5.8	0.1	0.5	1.8	1.8	1.6	2.2	-1.2	-0.3	1.9	2.4	0.9
Mouth/teeth dental problems: Mouth ulcers	2.2	3.5	7.2	2.2	2.4	1.9	1.8	1.8	1.3	-2.7	-1.1	2.1	1.8	-1.0
Medication for cholesterol	2.5	3.8	8.4	2.5	2.4	2.0	2.9	-0.5	0.7	-1.5	-1.3	2.2	2.2	-1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.8	0.3	0.3	-0.5	-0.9	-0.3	0.5	0.8	0.6	-0.3	-0.7	-0.6
Back pain experienced in last month	0.8	1.1	6.1	0.7	0.6	0.3	-0.1	-2.5	-1.1	-0.2	-1.4	-0.1	-0.5	-1.3
Mineral and other dietary supplements	0.5	0.6	1.1	0.6	0.5	0.8	0.7	-1.1	-0.9	-0.9	-1.0	0.7	1.0	-0.3
Breast cancer (self-reported)	1.7	2.0	4.1	1.2	1.9	1.4	1.3	0.7	2.0	-1.8	-1.7	1.3	1.0	-0.6
Asthma (self-reported)	8.0	15.9	29.9	-4.8	-3.0	-4.3	-4.3	-2.8	-3.1	3.5	2.9	-5.0	-5.5	3.4
Osteoporosis (self-reported)	0.5	0.6	1.7	0.7	0.6	1.1	0.6	-1.3	-0.3	-1.1	-0.3	0.6	0.4	-0.6
Osteoarthritis (self-reported)	0.1	0.2	1.0	-0.3	-0.2	-0.2	-1.0	-0.5	-0.2	0.1	-0.5	-0.1	-0.1	-0.1
Medication: Aspirin	1.2	1.5	5.9	-0.8	-2.4	-1.4	-1.1	-0.1	-0.7	1.5	1.2	-1.2	-1.1	-0.1
Medication: Gliclazide	0.4	0.5	1.5	-0.3	-1.2	-0.2	-0.4	-1.2	-0.8	0.3	-0.2	-0.6	-0.7	-0.5
Illnesses of father: None of the above (group 1)	1.2	1.5	3.2	1.6	1.8	1.4	1.1	1.4	0.1	-1.0	-0.9	1.3	0.8	-1.4
Smoking status: Current	7.0	11.2	21.3	-4.0	-4.6	-4.0	-4.0	-0.1	-2.2	3.7	3.2	-3.5	-2.9	1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	8.3	17.5	25.9	4.8	5.1	4.6	3.8	4.1	3.7	-4.8	-4.2	4.2	4.1	-2.0
Whole body water mass	0.3	1.7	5.6	-1.4	-0.1	-1.0	-2.4	-0.6	-0.7	1.0	0.1	-1.7	-2.2	0.6
Leg predicted mass (right)	0.3	1.6	4.8	-1.1	-0.2	-1.0	-2.0	-1.0	-0.5	1.4	0.3	-1.7	-2.2	-0.0
Arm fat mass (left)	2.1	8.6	14.4	-2.0	-2.5	-3.2	-3.8	-3.7	-3.6	2.4	0.9	-3.5	-3.6	-0.8
Number of self-reported non-cancer illnesses	7.7	13.4	26.2	-4.3	-5.1	-4.2	-4.3	-1.0	-2.5	3.9	3.4	-3.7	-3.4	2.7
Average weekly champagne plus white wine intake	0.4	0.5	2.8	1.1	1.7	0.5	0.2	0.2	0.3	-0.4	-0.4	0.5	0.2	-0.9
Miserableness	0.3	0.5	2.5	-1.6	-0.4	0.2	-0.8	-0.4	0.3	0.7	0.2	-0.5	-0.6	1.0
Guilty feelings	1.5	2.2	5.8	0.1	1.5	1.7	1.9	-2.4	1.2	-1.6	-2.0	0.8	0.2	1.1
Wears glasses or contact lenses	0.3	0.3	1.1	-0.4	0.1	0.1	0.6	-0.6	1.1	-0.8	-0.1	0.2	-0.3	1.1
Ever taken oral contraceptive pill	1.2	1.3	7.0	-0.6	-0.2	-0.2	-0.8	-2.6	-2.0	0.7	0.4	-0.7	-1.2	0.1
Hearing aid user	0.3	0.4	0.8	-0.3	0.3	-0.5	-0.5	-0.9	0.7	-0.4	-0.9	-0.5	-0.8	-0.7
Mother’s age at death	0.3	0.4	1.6	0.6	0.9	-0.2	0.0	0.6	1.3	-0.1	-0.8	-0.0	-0.0	-0.8
Financial situation satisfaction	0.7	0.8	2.3	1.1	1.0	0.9	1.3	0.1	1.1	-0.6	-1.5	0.4	-0.1	-0.8
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.7	-0.8	0.3	0.1	0.0	-1.4	-0.4	-0.1	-0.6	-0.5	-0.6	1.6
Commuting to job workplace: Public transport	0.7	0.9	2.2	-1.1	-0.2	-1.3	-0.7	-0.1	-0.3	0.8	1.5	-0.7	-0.8	1.4
Eye problems/disorders: Glaucoma	0.7	0.8	3.2	1.2	1.0	0.4	0.4	-1.0	0.5	-0.6	-1.1	0.0	-0.1	-1.8
Medication: Blood pressure	4.4	8.3	14.3	-3.1	-3.3	-3.4	-3.7	-0.2	-1.5	2.7	2.2	-3.8	-3.6	2.0
Pain type(s) experienced in last month: Hip pain	0.2	0.2	1.0	-0.5	-0.5	-0.3	-1.0	-0.5	0.1	0.4	0.6	0.3	0.1	0.0
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.1	-0.3	-0.7	-1.0	-0.6	0.9	1.0	0.9	1.0	-0.7	-1.0	-0.4
High cholesterol (Self-reported)	0.5	0.9	3.6	0.8	-1.9	-0.9	0.5	-1.1	0.8	0.8	0.6	-0.0	0.2	-1.4
Medication: Bendroflumethiazide	0.7	1.1	3.4	-0.8	-1.6	-1.0	-1.0	0.0	-0.0	1.0	1.0	-1.4	-1.8	-0.0
Medication: Paracetamol	0.4	0.6	1.7	0.9	0.9	0.5	0.0	1.3	0.2	-1.0	-0.5	0.4	0.9	-1.0
Medication: Lisinopril	0.6	0.8	3.4	-1.0	-1.8	0.3	-0.2	1.1	0.3	0.4	1.4	0.3	0.3	1.1
Medication: Atorvastatin	0.5	0.6	1.8	0.6	-1.4	-0.6	0.1	0.6	-0.4	1.2	0.8	-0.5	-0.4	-1.0
Illnesses of father: High blood pressure	1.0	1.2	3.3	-0.7	-0.7	-1.1	-0.4	-1.8	-0.5	1.0	0.9	-1.7	-1.7	0.4
Alcohol drinker status: Never	0.2	0.3	1.1	0.6	-0.1	-0.4	-0.2	0.3	0.8	0.4	-0.4	0.1	0.4	-1.0
Ever smoked	0.5	0.9	2.7	-1.0	0.0	-0.7	-0.7	-1.5	-1.6	0.6	0.1	-0.6	-0.6	1.5
Basal metabolic rate	0.6	3.1	8.0	-1.9	-0.8	-1.7	-2.8	-1.2	-1.4	1.6	0.4	-2.2	-2.7	0.5
Leg fat percentage (left)	4.7	16.8	26.7	-3.4	-3.9	-4.9	-5.2	-4.6	-4.8	3.7	1.8	-4.9	-4.7	-0.1
Arm fat-free mass (left)	0.9	4.8	13.8	-2.5	-1.0	-2.2	-3.7	-1.0	-1.8	1.9	0.6	-2.8	-3.2	1.0
Number of operations (self-reported)	0.6	0.9	2.9	-1.2	-1.7	-0.7	-0.8	-0.8	-0.9	0.7	0.7	-0.5	-0.9	0.9
Average weekly beer plus cider intake	1.3	1.9	6.0	-1.6	-1.7	-1.7	-1.4	-1.1	0.6	2.5	0.7	-1.3	-0.7	0.6
Irritability	1.8	3.0	6.5	-2.5	-0.7	-1.5	-1.6	-1.4	-1.4	0.7	1.0	-2.2	-2.4	2.5
Risk taking	0.4	0.7	2.6	0.0	0.5	0.4	0.6	1.6	0.2	0.0	0.4	1.3	1.3	0.0
Ever had prostate specific antigen (PSA) test	1.0	1.1	2.9	0.7	1.7	0.9	1.6	-0.2	-0.1	-1.5	-1.7	0.6	0.2	0.3
Fractured/broken bones in last 5 years	0.7	0.9	2.3	0.8	0.9	0.9	0.7	-1.5	0.6	-0.8	-1.5	0.7	0.9	-0.9
Age started oral contraceptive pill	1.2	1.5	5.7	0.9	2.3	0.9	0.3	0.6	1.4	-1.1	-2.4	0.3	-0.1	-0.7
Diastolic blood pressure, automated reading	5.8	18.0	38.2	-3.7	-5.3	-5.5	-6.2	1.3	-3.6	4.8	4.2	-4.4	-3.4	1.3
Ever depressed for a whole week	0.2	0.2	0.7	-0.1	0.5	0.9	-0.3	-0.4	-0.7	-0.4	-0.1	-0.3	-0.7	0.1
Unable to work because of sickness or disability	0.6	0.7	5.0	-0.1	-2.2	-0.3	-0.1	-1.1	0.5	0.4	0.3	-0.5	-0.5	-1.0
Commuting to job workplace: Cycle	1.8	2.2	4.3	1.7	1.6	1.8	2.1	0.2	1.6	-1.1	-1.1	1.6	1.6	-1.0
Myopia	0.8	1.2	3.7	0.3	0.2	0.7	1.9	0.8	1.3	-1.2	0.3	1.5	1.4	0.7
Vascular/heart problems diagnosed by doctor	2.0	5.4	10.7	2.1	3.2	3.0	2.6	-0.2	1.2	-1.4	-2.2	3.3	3.0	-1.0
Cholesterol lowering medication	0.3	0.5	2.8	-0.5	-1.7	-0.9	-0.3	0.2	0.4	0.8	0.8	-0.2	-0.2	0.1
Medication: Omeprazole (e.g. Zanprol)	4.6	5.5	12.2	-2.1	-1.8	-3.0	-2.9	-2.2	-1.7	3.5	1.3	-2.6	-2.7	0.2
Pain experienced in last month	1.9	3.2	7.1	1.4	1.3	1.7	2.7	2.2	2.1	-1.7	0.0	2.0	2.4	0.5
Supplements: Calcium	0.7	0.8	2.3	-0.9	-1.3	-1.2	-0.5	0.9	0.6	0.5	0.9	-0.1	0.0	1.5
Basal cell carcinoma (self-reported)	0.4	0.5	2.1	-0.7	-0.2	0.3	0.5	0.9	1.5	0.0	0.6	0.6	0.6	0.7
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.1	1.0	0.1	0.9	0.8	-0.7	0.5	-0.9	-0.1	0.4	0.3	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.5	-0.2	0.2	0.7	-0.2	0.1	-0.3	0.3	0.6	0.3	0.2	-0.4
Heart disease (siblings)	0.3	0.3	0.9	-0.5	-0.5	-0.3	-0.6	0.7	0.9	0.8	0.0	-0.4	-0.6	0.6
Alcohol drinker status: Previous	0.9	1.0	5.9	-1.0	-0.4	-0.9	-1.0	0.9	-2.4	0.7	0.6	-0.7	-0.4	0.0
Pack years of smoking	3.6	5.3	12.4	-1.1	-3.5	-2.9	-2.7	-1.0	-2.7	2.8	2.5	-1.9	-1.4	-0.6
Impedance of whole body	0.2	1.0	2.4	-0.7	-1.2	-0.5	1.4	0.2	0.2	1.3	1.1	0.8	1.5	0.3
Leg fat mass (left)	3.0	11.5	20.2	-2.9	-3.2	-3.8	-4.5	-3.7	-4.0	3.0	1.6	-4.0	-4.0	-0.1
Arm predicted mass (left)	0.9	4.3	12.7	-2.3	-1.1	-2.1	-3.6	-0.8	-1.7	1.9	0.5	-2.6	-3.0	0.9