[Hub]/) : Traits : Respiratory disease :

chr2:102,118,712-104,027,106

Best TWAS P=7.25e-74 · Best GWAS P=8.28e-60 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex SLC9A2 0.17 0.10 lasso 4 0.11 4.7e-13 7.8 7.8 7.0e-15 -0.25 1.00 0.00 TRUE
2 GTEx Colon Transverse IL18R1 0.14 0.00 enet 41 0.00 2.1e-01 3.9 11.9 1.7e-32 -0.41 0.04 0.48 TRUE
3 GTEx Whole Blood IL18R1 0.06 0.00 enet 14 0.01 2.1e-02 -13.7 8.2 3.3e-16 -0.25 0.17 0.05 FALSE
4 NTR Blood IL18R1 0.05 0.02 bslmm 582 0.02 5.1e-07 4.9 6.7 1.9e-11 -0.30 0.99 0.00 FALSE
5 NTR Blood IL18RAP 0.14 0.16 lasso 7 0.19 1.1e-59 10.5 -6.0 1.4e-09 0.27 1.00 0.00 FALSE
6 ROSMAP Brain Pre-frontal Cortex IL1RL2 0.08 0.02 enet 33 0.03 2.3e-04 6.6 -9.5 1.6e-21 0.47 0.17 0.19 FALSE
7 YFS Blood IL18RAP 0.41 0.55 bslmm 562 0.62 4.2e-269 10.5 -6.8 9.5e-12 0.33 1.00 0.00 FALSE
8 The Cancer Genome Atlas Bladder Urothelial Carcinoma IL1RL1 0.04 0.03 lasso 7 0.03 8.1e-04 -13.7 -14.4 3.5e-47 0.52 0.25 0.11 FALSE
9 The Cancer Genome Atlas Breast Invasive Carcinoma IL18R1 0.05 0.01 blup 108 0.03 1.8e-07 -13.7 9.1 1.0e-19 -0.08 0.99 0.00 FALSE
10 The Cancer Genome Atlas Breast Invasive Carcinoma IL1RL1 0.02 0.01 blup 78 0.01 1.5e-03 14.1 -15.4 2.5e-53 0.64 0.15 0.26 FALSE
11 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma IL1RL1 0.04 0.04 lasso 8 0.04 1.7e-05 -16.3 -17.4 6.3e-68 0.93 0.01 0.99 TRUE
12 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma IL18R1 0.06 0.01 blup 108 0.04 2.6e-05 -1.2 -8.1 6.4e-16 0.62 0.02 0.84 FALSE
13 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma IL18RAP 0.03 0.02 blup 94 0.02 1.2e-03 -13.7 13.7 6.3e-43 -0.64 0.01 0.91 FALSE
14 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma IL1RL1 0.08 0.08 enet 9 0.08 1.2e-09 -16.3 -18.1 1.9e-73 0.94 0.00 1.00 FALSE
15 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma IL1RL2 0.04 0.04 enet 5 0.03 1.9e-04 -12.1 -12.9 2.6e-38 0.69 0.06 0.41 FALSE
16 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma IL1RL1 0.18 0.06 blup 78 0.15 3.7e-09 14.1 -17.9 1.5e-71 0.83 0.01 0.99 TRUE
17 The Cancer Genome Atlas Lung Adenocarcinoma IL1RL1 0.03 0.01 blup 78 0.02 4.7e-03 -15.4 -18.2 7.2e-74 0.85 0.01 0.95 TRUE
18 The Cancer Genome Atlas Pancreatic Adenocarcinoma IL1RL1 0.19 0.05 blup 78 0.10 7.1e-05 14.3 -16.8 2.3e-63 0.64 0.13 0.66 TRUE
19 The Cancer Genome Atlas Prostate Adenocarcinoma IL1R1 0.36 0.19 enet 28 0.23 1.1e-23 -11.0 7.6 2.4e-14 -0.51 0.70 0.30 TRUE
20 The Cancer Genome Atlas Thyroid Carcinoma IL1RL1 0.05 0.03 enet 6 0.03 9.7e-04 -16.3 -16.3 5.6e-60 0.95 0.00 0.99 FALSE
21 The Cancer Genome Atlas Thyroid Carcinoma SLC9A2 0.05 0.01 blup 93 0.02 8.6e-03 6.7 6.7 2.3e-11 -0.17 0.02 0.82 TRUE