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chr5:111,499,732-112,950,045

Best TWAS P=2.68e-11 · Best GWAS P=3.05e-11 conditioned to 0.305

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
23	The Cancer Genome Atlas	Thyroid Carcinoma	APC	0.02	0.02	enet	5	0.02	4.2e-03	-6.4	6.7	2.7e-11	-0.95	0.02	0.90	TRUE
3	GTEx	Artery Aorta	REEP5	0.17	0.07	lasso	13	0.10	4.2e-06	6.0	6.6	4.1e-11	-0.88	0.07	0.93	FALSE
17	NTR	Blood	REEP5	0.03	0.04	lasso	9	0.04	3.3e-12	6.0	6.4	2.0e-10	-0.81	0.29	0.71	FALSE
4	GTEx	Cells Transformed fibroblasts	CTC-487M23.5	0.07	0.03	lasso	3	0.03	2.9e-03	-6.6	-6.3	2.3e-10	0.90	0.03	0.90	FALSE
9	GTEx	Nerve Tibial	XBP1P1	0.06	0.05	lasso	2	0.04	6.1e-04	5.0	6.1	1.3e-09	-0.87	0.04	0.94	FALSE
12	GTEx	Skin Not Sun Exposed Suprapubic	CTC-487M23.7	0.08	0.09	enet	7	0.10	3.9e-06	5.4	6.0	1.6e-09	-0.80	0.30	0.61	FALSE
16	GTEx	Testis	REEP5	0.22	0.14	lasso	5	0.14	6.6e-07	5.5	5.9	3.9e-09	-0.75	0.51	0.42	FALSE
14	GTEx	Skin Sun Exposed Lower leg	CTC-487M23.5	0.17	0.07	lasso	6	0.06	7.7e-06	5.6	5.9	4.3e-09	-0.70	0.40	0.59	FALSE
20	The Cancer Genome Atlas	Prostate Adenocarcinoma	SRP19	0.05	0.05	lasso	1	0.05	4.5e-06	5.8	-5.8	7.3e-09	0.81	0.06	0.92	FALSE
21	The Cancer Genome Atlas	Soft Tissue Sarcoma	SRP19	0.07	0.03	lasso	4	0.02	2.4e-02	5.8	-5.7	9.7e-09	0.81	0.02	0.71	FALSE
8	GTEx	Esophagus Muscularis	REEP5	0.18	0.09	lasso	4	0.14	5.9e-09	5.5	5.7	1.1e-08	-0.76	0.67	0.33	FALSE
11	GTEx	Skin Not Sun Exposed Suprapubic	CTC-487M23.5	0.10	0.06	lasso	3	0.05	6.7e-04	5.5	5.7	1.1e-08	-0.72	0.12	0.68	FALSE
18	YFS	Blood	SRP19	0.02	0.01	bslmm	456	0.00	2.9e-02	6.4	5.7	1.1e-08	-0.62	0.03	0.82	FALSE
22	The Cancer Genome Atlas	Stomach Adenocarcinoma	REEP5	0.03	0.02	blup	47	0.03	4.1e-03	4.6	5.7	1.3e-08	-0.76	0.04	0.40	FALSE
15	GTEx	Skin Sun Exposed Lower leg	CTC-487M23.7	0.06	0.07	lasso	1	0.04	2.4e-04	5.6	5.6	2.2e-08	-0.66	0.43	0.42	FALSE
5	GTEx	Colon Transverse	REEP5	0.12	0.14	lasso	2	0.14	4.4e-07	5.5	5.6	2.5e-08	-0.71	0.68	0.28	FALSE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	SRP19	0.05	0.04	lasso	3	0.04	3.7e-05	5.4	-5.5	3.2e-08	0.71	0.28	0.68	FALSE
1	CommonMind	Brain Pre-frontal Cortex	SRP19	0.08	0.06	lasso	5	0.07	1.3e-08	5.3	-5.5	3.5e-08	0.73	0.57	0.43	FALSE
2	GTEx	Adipose Visceral Omentum	REEP5	0.09	0.05	lasso	5	0.02	4.9e-02	5.7	5.5	4.3e-08	-0.68	0.25	0.35	FALSE
6	GTEx	Esophagus Gastroesophageal Junction	REEP5	0.18	0.03	lasso	3	0.03	3.7e-02	5.4	5.5	4.6e-08	-0.77	0.04	0.85	FALSE
7	GTEx	Esophagus Mucosa	REEP5	0.19	0.10	lasso	5	0.09	1.5e-06	5.4	5.2	1.7e-07	-0.74	0.47	0.38	FALSE
10	GTEx	Pituitary	REEP5	0.19	0.02	enet	16	0.02	1.1e-01	5.6	5.2	2.5e-07	-0.53	0.09	0.28	FALSE
13	GTEx	Skin Sun Exposed Lower leg	REEP5	0.08	0.05	lasso	4	0.03	1.9e-03	4.5	5.1	3.0e-07	-0.70	0.57	0.37	FALSE