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chr11:45,945,837-47,953,477

Best TWAS P=4.46e-11 · Best GWAS P=2.11e-09 conditioned to 0.0746

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Liver	ARHGAP1	0.12	0.05	enet	4	0.05	1.5e-02	5.4	-6.6	4.5e-11	-0.72	0.07	0.30	TRUE
7	GTEx	Ovary	ARHGAP1	0.25	0.09	lasso	16	0.18	3.8e-05	5.6	-6.5	7.8e-11	-0.86	0.08	0.75	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	PACSIN3	0.11	0.00	bslmm	292	0.04	1.8e-06	-3.4	6.3	2.7e-10	0.52	0.06	0.62	FALSE
3	GTEx	Liver	ZNF408	0.10	0.09	lasso	3	0.08	3.5e-03	5.4	-6.1	9.7e-10	-0.83	0.06	0.55	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	ARHGAP1	0.02	0.01	blup	26	0.02	2.7e-04	5.3	-6.1	1.4e-09	-0.74	0.02	0.70	FALSE
20	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CKAP5	0.09	0.01	blup	58	0.04	2.9e-03	4.4	5.9	3.3e-09	0.66	0.02	0.85	FALSE
10	GTEx	Skin Not Sun Exposed Suprapubic	ATG13	0.12	0.07	lasso	5	0.06	3.3e-04	5.6	-5.9	4.2e-09	-0.95	0.04	0.96	FALSE
1	GTEx	Adipose Subcutaneous	ARHGAP1	0.08	0.03	lasso	6	0.05	3.4e-05	4.9	-5.6	2.2e-08	-0.48	0.62	0.25	FALSE
22	The Cancer Genome Atlas	Stomach Adenocarcinoma	HARBI1	0.05	0.02	blup	12	0.02	1.5e-02	5.7	5.6	2.2e-08	0.97	0.01	0.76	FALSE
9	GTEx	Skin Not Sun Exposed Suprapubic	ARHGAP1	0.06	0.01	lasso	9	0.00	2.8e-01	4.9	-5.5	2.9e-08	-0.49	0.13	0.26	FALSE
15	GTEx	Thyroid	C11orf49	0.09	0.05	lasso	3	0.04	3.0e-04	5.4	-5.4	5.5e-08	-0.65	0.31	0.66	FALSE
8	GTEx	Pancreas	ARHGAP1	0.09	0.06	lasso	7	0.04	6.4e-03	5.3	-5.4	6.2e-08	-0.58	0.17	0.24	FALSE
14	GTEx	Spleen	LRP4	0.15	0.14	lasso	5	0.12	6.5e-04	5.4	-5.4	6.7e-08	-0.63	0.12	0.33	FALSE
16	GTEx	Uterus	C11orf49	0.24	0.24	lasso	13	0.24	1.3e-05	5.3	-5.4	7.3e-08	-0.65	0.10	0.29	FALSE
2	GTEx	Esophagus Muscularis	CKAP5	0.05	0.03	lasso	4	0.04	3.3e-03	4.3	5.4	8.7e-08	0.42	0.39	0.12	FALSE
13	GTEx	Skin Sun Exposed Lower leg	ATG13	0.08	0.05	lasso	4	0.05	5.1e-05	6.0	-5.4	8.7e-08	-0.98	0.04	0.96	FALSE
5	GTEx	Muscle Skeletal	ARHGAP1	0.03	0.05	lasso	2	0.04	1.2e-04	5.3	-5.3	9.9e-08	-0.64	0.28	0.56	FALSE
11	GTEx	Skin Sun Exposed Lower leg	DDB2	0.08	0.10	lasso	4	0.10	5.8e-09	4.9	5.3	1.3e-07	0.39	0.18	0.82	FALSE
6	GTEx	Nerve Tibial	ARHGAP1	0.10	0.03	enet	14	0.05	9.7e-05	5.4	-5.3	1.4e-07	-0.52	0.48	0.47	FALSE
21	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ARHGAP1	0.11	0.01	blup	26	0.03	2.7e-02	4.5	-5.2	1.6e-07	-0.51	0.01	0.35	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MDK	0.03	0.02	lasso	3	0.02	2.3e-03	6.0	-5.2	2.1e-07	-0.94	0.01	0.97	FALSE
12	GTEx	Skin Sun Exposed Lower leg	ARHGAP1	0.08	0.01	lasso	5	0.02	1.4e-02	5.3	-5.2	2.4e-07	-0.54	0.25	0.14	FALSE
23	The Cancer Genome Atlas	Thyroid Carcinoma	PACSIN3	0.09	0.01	enet	5	0.03	3.1e-04	5.3	5.1	2.7e-07	0.74	0.01	0.89	FALSE