Hub : Genes

DDB2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0270 0.0160 2.4e-02 0.020 0.001 0.001 0.005 0.000 1.5e-03 0.24000 2.7e-01 0.07900 2.8e-01
2 GTEx Skin Not Sun Exposed Suprapubic 0.0690 0.0390 4.8e-03 0.023 NA 0.038 NA 0.023 1.8e-02 NA 3.5e-03 NA 1.8e-02
3 GTEx Skin Sun Exposed Lower leg 0.0780 0.0300 9.6e-07 0.096 NA 0.093 NA 0.104 2.5e-08 NA 4.4e-08 NA 5.8e-09
4 METSIM Adipose 0.0258 0.0137 5.2e-04 0.027 0.017 0.016 0.016 0.023 6.2e-05 0.00110 1.4e-03 0.00140 1.9e-04
5 NTR Blood 0.0075 0.0049 1.1e-02 0.003 0.000 -0.001 0.000 0.007 3.5e-02 0.26000 6.1e-01 0.21000 2.2e-03
6 ROSMAP Brain Pre-frontal Cortex 0.0401 0.0186 7.4e-05 0.032 0.027 0.031 0.027 0.026 4.6e-05 0.00018 7.1e-05 0.00016 2.3e-04
7 YFS Blood 0.0202 0.0098 5.7e-04 0.000 0.010 0.006 0.010 0.002 4.8e-01 0.00021 3.8e-03 0.00019 6.8e-02
8 TCGA Lung Squamous Cell Carcinoma 0.0168 0.0099 5.5e-03 0.030 0.017 0.018 NA 0.023 2.2e-04 0.00440 3.2e-03 NA 1.0e-03
9 TCGA Thyroid Carcinoma 0.0590 0.0330 1.9e-04 0.037 0.012 0.026 NA 0.016 1.6e-04 0.02000 1.3e-03 NA 8.6e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 1.0 1.6 4.7 0.7 2.2 1.2 -1.3 -1.1 0.1 -0.5 2.1 0.2
Bipolar Disorder or Schizophrenia 1.1 2.8 7.8 0.9 2.8 2.3 -1.7 0.8 -0.3 2.4 1.3 -0.5
Depressed Affect (Nagel 2018) 8.9 18.6 39.7 0.6 -4.7 -6.3 6.3 4.0 5.9 -1.0 -2.5 -2.8
Depression (Nagel 2018) 3.9 5.8 15.3 1.2 -2.0 -3.6 3.9 1.2 3.6 -1.9 -0.3 -0.2
Intelligence (Savage-Jansen 2018) 2.2 6.7 26.9 1.6 0.6 -1.5 1.3 -2.8 1.7 -5.2 3.3 2.3
Neuroticism (Nagel 2018) 5.9 13.8 29.6 -0.6 -4.3 -5.4 4.6 3.2 4.4 -1.5 -2.9 -3.8
Schizophrenia (2018) 1.4 2.9 12.4 0.6 1.8 2.0 -1.2 1.9 -0.5 3.5 -0.0 -0.8
Schizophrenia vs Biploar Disorder 1.7 2.3 6.1 0.2 1.8 2.2 -1.7 0.9 -1.6 2.5 0.5 0.2
Worry (Nagel 2018) 2.0 4.2 9.3 -1.1 -1.9 -3.0 2.2 1.2 2.2 -2.3 -1.2 -2.3
Alzheimer’s Disease (in mother) 0.8 0.9 4.4 -2.1 0.2 0.5 -0.8 -0.0 -1.0 -0.5 -1.1 -0.7
Alzheimer’s Disease (in father) 0.7 0.7 1.7 0.9 0.6 0.4 -0.6 -1.3 0.1 -1.3 1.2 0.5
Alzheimer’s Disease (including proxy) 0.7 1.0 3.2 -1.8 0.3 0.4 -1.1 -0.8 -0.6 -1.8 -0.1 -0.3
Crohns Disease (2017) 0.4 0.9 3.4 -0.6 0.4 -0.2 1.1 1.3 0.5 1.8 0.1 -1.1
Irritable Bowel Disease (IBD) 0.1 0.3 1.2 -0.2 0.6 -0.1 0.7 0.6 0.4 1.1 0.6 -0.1
Ulcerative Colitis (UC) 0.0 0.1 0.3 -0.3 0.4 0.1 0.1 0.2 -0.1 0.5 0.2 0.2
Major Depression (MDD) 1.4 1.6 4.5 0.3 0.2 -0.9 1.0 1.9 2.1 0.9 -0.2 -2.0
Reaction Time 6.2 11.7 27.8 0.2 4.5 5.3 -5.0 -1.4 -4.2 2.1 1.9 2.2
Verbal and Numeric Reasoning (VNR) 2.9 6.9 21.3 2.2 0.1 -2.0 2.0 -2.3 2.1 -4.6 3.0 3.0
Breast Cancer 0.7 1.8 3.6 -1.8 -1.5 -1.5 1.1 0.5 0.7 -0.7 -1.9 -1.5
Ovarian Cancer 1.0 1.3 3.9 0.6 0.5 0.7 -0.7 -2.0 -0.7 -1.6 1.2 1.3
Prostate Cancer 1.6 2.3 6.7 -1.8 -2.1 -1.8 1.1 -0.7 -0.2 -2.6 -1.2 0.2
Age at First Birth 0.2 0.2 0.7 -0.1 -0.8 -0.6 0.3 0.4 0.6 -0.2 -0.3 -0.6
Bipolar Disorder (2011) 1.1 1.1 3.0 -0.2 1.7 1.5 -1.3 -0.7 -0.4 -0.2 0.9 -1.0
Body Mass Index (BMI) (2010) 1.4 1.9 5.4 -0.7 -0.7 -0.4 0.2 2.3 -0.3 1.9 -2.3 -1.0
Coronary Artery Disease (CAD) 0.6 0.7 2.8 0.1 -0.1 0.1 0.4 1.1 0.4 1.7 -1.0 -0.8
Crohns Disease (2012) 0.7 1.1 5.9 -0.1 0.7 0.2 1.0 1.4 0.4 2.4 -0.0 -0.5
Mean Putamen Volume 1.3 1.5 4.2 -0.9 1.3 1.4 -1.3 1.2 -0.9 2.1 -0.7 -0.3
Fasting Glucose 10.5 12.5 27.6 3.8 4.6 3.2 -2.0 -3.5 -1.0 -0.5 5.2 4.8
HbA1C 0.3 0.4 1.0 0.7 0.2 0.3 -0.5 -1.0 0.4 -0.6 1.0 -0.1
HDL Cholesterol 21.5 35.9 75.7 3.9 6.0 5.1 -4.5 -8.7 -3.1 -5.6 8.0 6.7
LDL Cholesterol 2.0 3.1 9.9 -1.7 -2.1 -2.4 1.8 -0.4 0.1 -3.1 -1.2 0.4
Lupus 1.8 2.7 6.0 2.2 0.7 0.1 0.2 -2.5 0.8 -1.8 2.4 1.6
Neuroticism (2016) 3.4 4.9 12.0 0.3 -2.2 -3.1 3.2 1.8 3.5 -1.4 -0.6 -1.3
Primary Biliary Cirrhosis 2.0 2.8 6.2 2.1 2.5 1.9 -1.7 -0.8 -0.6 1.2 2.0 1.1
Rheumatoid Arthritis 0.8 1.1 3.6 -1.9 -1.0 -1.5 1.0 0.0 0.6 -1.3 -0.4 -0.3
Schizophrenia (2014) 1.8 4.1 10.6 1.3 3.3 2.7 -2.2 0.9 -0.5 2.9 1.5 -0.5
Triglycerides 4.7 7.8 13.0 -2.8 -3.3 -3.5 2.6 3.1 1.5 -1.1 -3.6 -2.5
Type 2 Diabetes (T2D) (2012) 0.9 1.0 2.6 -0.6 1.4 1.2 -1.6 -0.7 -1.4 -0.2 0.2 0.3
Ulcerative Colitis 0.2 0.3 0.8 -0.6 -0.3 -0.6 0.3 0.9 0.7 0.4 -0.5 -0.2
Blood Eosinophil Count 0.3 2.4 10.4 -3.2 -0.7 1.0 -1.4 -1.2 -1.3 -0.3 -1.8 -1.1
Blood Platelet Count 1.9 22.6 81.5 9.0 4.2 2.7 -0.5 -1.3 2.8 3.7 8.0 3.2
Blood Red Count 0.2 1.7 4.8 0.2 -1.3 0.9 -0.9 -1.9 -2.2 -1.2 -0.3 1.4
Blood White Count 1.0 7.2 15.2 -3.1 -3.0 -0.8 0.8 2.3 -0.1 3.6 -3.9 -3.3
Heel T-Score 16.3 129.7 285.6 3.7 14.3 16.9 -13.3 -11.6 -12.4 3.5 9.4 9.9
BMI 2.1 12.2 44.2 -1.5 -0.6 0.2 0.2 5.3 0.1 6.7 -4.6 -3.7
Height 2.3 44.4 98.6 8.9 8.7 5.5 -2.8 -6.3 -0.6 -1.5 9.9 8.1
Waist Hip Ratio (WHR) 1.1 5.0 12.0 2.2 1.9 -0.1 -0.3 -2.8 -0.0 -3.5 3.3 2.5
Systolic Blood Pressure 8.6 42.8 76.9 1.9 -5.3 -5.5 6.2 8.8 8.6 6.2 -4.4 -8.7
Smoking Status 2.0 4.7 10.3 2.9 2.7 2.4 -1.9 -1.0 -0.1 0.9 2.4 3.2
Allergy or Eczema 0.3 0.8 3.0 -1.7 -0.6 -0.7 0.2 -0.3 -0.1 -1.2 -1.1 -1.0
Cardiovascular Disease 6.9 22.7 52.6 -2.2 -3.9 -2.9 2.9 7.2 2.8 5.3 -6.1 -6.4
Hypothyroidism (self reported) 1.0 2.4 14.2 1.8 -0.0 0.2 0.3 1.9 0.6 3.8 -0.4 -0.3
Respiratory disease 0.8 1.7 4.2 1.0 -1.3 -1.6 1.5 1.4 2.0 0.5 -0.6 -1.1
Type 2 Diabetes (T2D) (2018) 0.4 0.8 2.0 -1.0 -0.4 -1.2 1.3 0.8 -0.0 -0.2 -1.4 -0.3
Lung FEV1/FVC ratio 0.4 2.1 5.9 -2.4 -0.5 0.1 -1.1 -1.4 -1.6 -2.2 -1.4 -0.4
Lung FVC 1.6 8.0 14.0 0.4 3.0 3.7 -3.6 -3.6 -2.7 -0.6 2.7 2.8
Neuroticism 5.9 14.3 32.4 1.0 -4.0 -5.7 5.6 3.4 5.3 -1.1 -1.4 -2.3
Chronotype (morning person) 2.8 6.4 22.6 -1.1 0.2 1.2 -1.4 3.2 -0.8 4.8 -2.8 -3.3
Hair Pigment 0.9 25.0 47.9 2.9 5.2 4.4 -4.2 -6.9 -2.5 -3.9 6.7 6.2
Tanning 0.1 1.3 2.9 -0.8 1.7 1.5 -1.4 -0.4 -1.2 0.3 1.0 1.1
Hand grip strength (left) 1.0 2.6 5.5 1.9 1.5 2.4 -1.8 -1.1 -0.9 0.7 2.0 1.6
Number of treatments/medications taken 2.4 4.3 7.4 0.3 -2.1 -2.5 2.3 2.7 2.4 1.2 -2.1 -2.1
Average weekly spirits intake 0.4 0.5 2.1 1.4 0.2 0.6 0.1 0.0 -0.3 1.4 0.6 0.0
Sensitivity / hurt feelings 2.9 5.0 9.1 -1.7 -2.8 -3.0 2.3 2.1 1.4 -0.7 -2.4 -2.7
Frequency of depressed mood in last 2 weeks 3.6 5.0 14.0 0.3 -2.1 -3.7 3.0 1.0 3.1 -2.5 -0.2 -0.8
Hearing difficulty/problems: Yes 0.6 1.0 3.0 0.5 0.1 -0.9 0.7 -1.1 1.7 -1.0 1.4 -0.5
Relative age of first facial hair 0.6 1.2 2.8 0.9 1.7 1.3 -0.5 -1.5 -0.5 -0.2 1.5 0.9
Other serious medical condition/disability diagnosed by doctor 1.4 1.8 6.9 2.6 1.3 0.7 0.3 0.4 0.6 1.8 1.5 0.9
Ever used hormone-replacement therapy (HRT) 2.3 3.0 5.2 0.9 -2.3 -2.1 2.3 2.0 1.8 1.3 -1.4 -0.6
Ever had hysterectomy (womb removed) 0.8 1.0 2.1 -0.8 -1.3 -1.2 0.9 0.0 0.6 -1.4 -0.8 -0.9
Systolic blood pressure, automated reading 7.5 21.9 41.2 2.3 -3.3 -3.5 4.8 6.4 6.0 5.7 -2.5 -5.4
Eye problems/disorders: Diabetes related eye disease 1.4 1.6 5.4 -0.9 -0.5 0.6 -0.5 1.1 -1.7 1.7 -2.3 0.1
Angina 1.5 2.0 5.1 -0.7 -1.4 -2.3 1.6 1.2 1.6 -0.3 -1.7 -1.0
Medication for hormone replacement therapy 2.3 2.5 6.8 2.5 1.2 1.7 -0.4 -0.8 -0.0 0.9 2.0 2.6
Vitamin and mineral supplements 0.5 0.7 2.5 -1.1 -0.5 -0.7 0.6 0.5 0.4 -0.4 -0.9 -1.6
Supplements: Zinc 1.0 1.1 2.2 1.1 1.3 1.5 -1.1 -0.4 -0.2 0.9 1.4 0.9
Medication: Co-codamol 0.4 0.5 1.4 1.1 -0.2 -0.5 0.9 -0.1 1.2 -0.4 -0.1 0.3
Medication: Metformin 0.3 0.5 1.3 -0.2 1.1 0.6 -0.5 0.5 -1.0 0.7 -0.8 -0.4
Diabetes (father) 0.7 0.9 2.8 -1.4 -0.5 -0.3 0.0 1.2 -0.2 0.8 -0.9 -1.7
Diabetes (mother) 0.6 0.7 3.0 0.3 -0.3 -0.6 0.6 -0.7 0.3 -1.7 0.0 1.4
Severe depression (siblings) 2.0 2.3 5.2 -0.5 1.9 2.2 -2.3 -1.6 -1.7 -0.4 1.0 0.3
Pack years adult smoking proportion 1.1 1.6 3.7 1.5 1.9 0.9 -0.1 0.9 1.2 1.8 1.4 -0.2
Impedance of leg (right) 1.0 5.1 28.1 -2.0 -1.7 -2.4 0.9 -1.4 1.3 -5.3 0.1 0.1
Leg fat-free mass (left) 1.5 7.8 18.5 3.4 3.9 3.6 -1.6 -0.3 -1.5 4.3 2.1 1.6
Trunk fat percentage 1.8 7.1 18.3 -0.9 -1.2 -1.2 1.1 4.3 0.7 3.9 -3.8 -3.3
Hand grip strength (right) 0.3 0.9 2.7 1.6 0.6 1.3 -0.8 -0.5 -0.1 1.0 1.0 0.8
Townsend deprivation index at recruitment 0.5 0.7 2.8 1.7 0.2 -0.5 0.3 0.4 1.2 -0.6 0.9 0.3
Current tobacco smoking 1.1 1.8 6.2 2.5 1.1 0.1 0.1 -0.2 1.6 -0.3 1.8 1.8
Average weekly fortified wine intake 0.6 0.7 1.7 0.7 0.1 -1.1 0.7 0.3 1.2 -0.4 1.3 -0.7
Maternal smoking around birth 1.5 2.2 9.1 0.7 0.1 -0.4 0.2 2.5 1.2 3.0 -0.6 -1.4
Fed-up feelings 8.7 15.9 31.7 1.1 -4.5 -5.6 5.6 3.8 5.6 -0.3 -2.1 -2.8
Frequency of unenthusiasm / disinterest in last 2 weeks 2.2 3.0 7.8 1.4 -1.3 -2.5 2.8 0.8 2.7 -0.9 0.5 -0.2
Relative age voice broke 1.1 1.6 3.3 0.3 1.7 1.8 -1.7 -1.5 -1.3 -0.1 1.2 0.2
Taking other prescription medications 0.6 0.9 2.8 1.7 1.4 0.4 -0.6 0.3 0.4 1.6 0.8 -0.2
Age when periods started (menarche) 2.4 5.7 29.9 -1.6 -1.1 -0.5 0.0 -2.9 -1.7 -5.5 0.5 2.4
Bilateral oophorectomy (both ovaries removed) 1.4 1.7 3.3 0.4 -1.2 -1.4 1.8 1.5 1.8 0.4 -1.0 -1.1
Heel bone mineral density (BMD) T-score, automated (left) 12.2 27.7 59.0 2.0 6.5 7.7 -5.8 -5.5 -6.0 1.8 4.0 5.0
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 1.0 -0.2 -0.4 -0.6 0.6 0.6 0.5 0.2 -0.3 -1.0
Qualifications: CSEs or equivalent 0.2 0.2 0.8 -0.1 -0.0 -0.5 0.1 0.4 0.9 -0.1 -0.4 -0.8
Serious illness, injury or assault to yourself 0.2 0.2 0.7 -0.0 0.8 0.2 -0.5 -0.4 0.3 -0.4 0.6 0.1
High blood pressure 12.8 35.6 65.4 -3.2 -6.1 -5.2 4.7 8.1 4.4 4.8 -7.4 -7.8
Hayfever, allergic rhinitis or eczema 0.3 0.8 2.4 -1.5 -0.7 -0.8 0.2 -0.3 -0.1 -1.2 -1.1 -0.7
Multivitamins +/- minerals 0.6 0.8 2.5 1.3 -0.5 -0.6 1.0 0.1 0.7 -0.2 0.8 1.6
Stomach or abdominal pain in last month 0.9 1.1 3.2 -0.6 1.8 0.8 -1.0 -1.4 -1.1 -1.0 0.8 0.2
Supplements: Glucosamine 1.8 2.4 5.9 0.6 1.5 2.4 -1.5 -1.7 -1.3 1.0 1.4 1.8
Diverticular disease/diverticulitis (self-reported) 0.5 0.5 1.5 0.8 0.6 0.4 -0.3 -0.9 -0.1 -0.9 0.7 1.2
Medication: Atenolol 0.7 0.8 1.5 -1.0 0.1 1.2 -0.9 0.4 -1.2 1.2 -1.1 -0.2
Medication: Levothyroxine sodium 1.1 1.9 7.4 0.6 -0.9 -0.5 0.4 2.1 0.8 2.7 -1.2 -1.4
Sitting height 2.1 14.8 35.0 4.5 5.9 4.9 -3.1 -2.6 -0.7 2.0 5.1 2.6
Chronic bronchitis/emphysema (father) 0.8 1.0 4.2 2.0 0.7 0.8 -0.5 0.6 0.5 1.6 0.4 0.4
High blood pressure (mother) 3.2 4.5 6.7 -0.8 -2.2 -2.4 2.6 2.5 1.7 1.6 -2.4 -2.3
Body mass index (BMI) 1.6 6.9 24.7 -0.8 -0.8 -0.1 0.4 3.8 -0.1 5.0 -3.5 -3.0
Impedance of leg (left) 0.9 4.4 23.6 -1.7 -1.5 -2.4 0.9 -1.1 1.6 -4.9 0.1 -0.1
Leg predicted mass (left) 1.4 7.6 18.7 3.3 3.8 3.5 -1.6 -0.2 -1.5 4.3 2.0 1.5
Trunk fat mass 1.0 4.4 17.9 0.2 0.3 0.2 0.3 3.3 0.1 4.2 -2.4 -2.2
Waist circumference 0.5 1.8 5.3 0.5 -0.1 -0.5 0.7 2.2 0.4 2.3 -1.4 -1.6
Number of incorrect matches in round 2.5 4.1 8.6 -1.6 1.9 2.5 -2.9 -2.6 -2.9 -0.7 0.7 0.3
Past tobacco smoking 1.3 2.4 7.2 -2.7 -1.3 -1.2 0.7 -0.7 -1.1 -2.5 -1.4 -0.6
Alcohol usually taken with meals 1.3 2.1 8.6 -1.4 -1.5 -1.3 0.6 -1.7 -0.4 -2.9 -0.8 -0.0
Nervous feelings 3.1 5.7 9.6 -2.8 -2.4 -2.9 1.5 1.8 1.2 -2.3 -2.7 -3.1
Frequency of tenseness / restlessness in last 2 weeks 1.2 1.9 5.0 0.4 -0.7 -2.2 1.9 0.8 2.2 -1.2 0.5 -0.7
Hearing difficulty/problems with background noise 6.2 9.9 22.8 0.4 -3.7 -4.8 4.2 2.4 4.5 -1.1 -0.9 -2.6
Hair/balding pattern: Pattern 2 1.2 1.5 3.1 0.9 1.2 1.8 -1.6 -1.5 -0.8 -0.0 1.6 0.4
Had menopause 0.9 1.2 4.8 1.8 0.7 0.1 0.2 -0.4 0.7 0.2 1.1 2.2
Had other major operations 0.6 0.8 3.3 0.3 -0.3 -0.5 0.5 -1.2 -0.2 -1.8 0.5 1.1
Forced vital capacity (FVC) 4.1 15.7 28.4 3.0 4.7 4.0 -3.0 -5.2 -2.3 -1.9 5.3 4.6
Heel bone mineral density (BMD) T-score, automated (right) 14.2 32.4 65.6 1.9 7.2 8.1 -6.5 -6.2 -6.5 1.2 4.7 5.1
Ever unenthusiastic/disinterested for a whole week 2.1 2.6 8.6 1.0 2.9 1.9 -1.2 -1.3 -1.3 0.5 2.0 0.7
Qualifications: None of the above 0.8 1.6 4.2 -0.4 -1.0 -1.2 0.6 2.0 1.1 1.3 -1.6 -1.4
Financial difficulties in last 2 years 0.3 0.3 0.8 0.5 -0.2 -0.7 0.7 0.7 0.9 0.0 0.5 -0.6
Mouth/teeth dental problems 1.4 2.1 7.9 2.8 -0.1 -0.6 1.9 -0.9 1.1 -0.1 1.9 1.2
Heart attack 0.5 0.6 2.8 1.7 0.4 -0.4 0.8 0.4 1.0 0.6 0.4 0.7
Allergy 0.1 0.3 0.7 0.7 0.5 0.5 0.3 0.3 -0.4 0.8 0.8 0.2
Pain all over the body in last month 0.7 0.8 3.0 1.2 0.3 -0.1 0.8 0.6 1.0 1.7 0.3 0.4
Diabetes (self-reported) 0.3 0.4 1.8 0.1 -0.4 -0.2 0.6 0.8 -0.2 0.6 -1.3 -0.2
Hayfever/allergic rhinitis (self-reported) 2.9 3.8 9.6 -0.1 -2.6 -3.1 2.5 1.6 2.5 -1.1 -0.9 -0.7
Medication: Ramipril 2.1 2.6 8.2 -0.9 -0.1 -0.0 -0.3 2.3 0.9 2.5 -1.4 -2.9
Medication: Simvastatin 1.4 2.0 4.8 0.3 -2.0 -1.3 1.2 2.2 0.9 1.0 -1.8 -1.0
Fluid intelligence score 2.5 5.2 21.5 1.3 0.6 -1.1 1.1 -2.7 1.2 -4.6 2.5 2.5
Illnesses of siblings 3.0 4.2 13.6 0.5 0.4 0.3 0.3 -3.0 -1.1 -3.2 1.8 3.7
Neuroticism score 4.3 9.1 21.0 0.7 -3.1 -4.5 4.6 2.4 4.1 -1.2 -1.2 -2.0
Weight 0.7 3.4 15.2 2.0 2.3 2.0 -0.7 1.2 -0.5 3.9 0.2 -0.2
Impedance of arm (right) 0.1 0.7 1.9 -1.4 -0.5 -0.8 -0.1 0.6 -0.1 -1.3 -0.8 -0.8
Arm fat percentage (right) 2.3 9.2 24.3 -1.5 -1.3 -0.6 0.5 4.6 -0.1 4.9 -4.4 -3.7
Trunk fat-free mass 2.8 15.9 31.5 4.2 5.6 5.1 -3.0 -3.4 -2.3 1.6 4.7 4.1
Hip circumference 1.5 6.4 15.3 -0.0 -1.2 -1.3 1.7 3.8 1.4 3.9 -3.0 -3.3
Time employed in main current job 3.1 3.6 6.1 -1.2 2.5 2.2 -2.2 -2.0 -2.2 -1.5 1.5 1.1
Alcohol intake versus 10 years previously 0.7 1.1 3.4 -1.7 0.0 0.8 -1.0 -0.2 -1.9 -0.3 -1.1 0.6
Father’s age at death 1.5 2.0 3.6 -1.9 -1.8 -1.6 1.8 0.8 0.4 -1.4 -1.3 -1.2
Worrier / anxious feelings 0.4 0.7 2.6 -1.1 -0.4 -0.8 -0.0 0.6 0.2 -1.0 -0.5 -1.6
Frequency of tiredness / lethargy in last 2 weeks 3.2 5.2 13.9 1.1 -1.6 -3.7 3.6 1.8 3.1 -1.3 -0.2 -1.3
Falls in the last year 1.8 2.5 5.5 2.4 1.2 -0.1 0.9 1.4 2.2 2.3 1.5 -0.6
Hair/balding pattern: Pattern 3 3.5 5.2 11.0 -2.2 -2.0 -1.9 2.0 2.8 0.6 0.9 -3.3 -3.2
Number of live births 1.0 1.4 4.7 0.3 0.8 1.8 -1.9 0.2 -0.9 2.2 0.0 0.2
Forced expiratory volume in 1-second (FEV1) 2.8 9.6 22.4 1.3 3.1 3.1 -2.5 -4.7 -2.5 -2.5 3.5 3.4
Pulse rate 1.6 2.7 8.1 2.4 2.2 1.0 -0.8 -1.3 0.2 -0.1 2.9 1.5
Happiness 2.0 2.4 5.2 1.2 -1.4 -1.9 2.3 1.8 2.3 0.3 -0.1 -0.7
Noisy workplace 0.9 1.1 5.0 0.4 1.5 1.3 -0.8 -0.0 -0.4 2.2 0.4 -0.4
Qualifications: A levels/AS levels or equivalent 1.0 2.1 9.1 -0.4 -1.3 -1.9 1.5 -1.3 0.8 -3.0 0.4 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 2.4 -1.6 -0.3 -0.8 0.3 -0.1 -0.0 -0.9 -0.5 -0.8
Mouth/teeth dental problems: Dentures 0.5 0.9 2.1 0.5 0.9 0.4 -0.4 -1.3 -0.3 -1.4 1.0 1.3
Asthma 1.4 2.7 6.0 0.3 -1.9 -2.0 1.4 1.7 2.4 0.4 -1.3 -1.9
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.5 7.6 -0.2 -1.3 -1.1 0.4 -1.4 0.7 -2.8 -0.1 -0.4
Medication: Cholesterol lowering 0.7 1.1 4.6 0.7 -0.5 -0.2 0.0 2.1 0.8 1.6 -0.9 -0.6
Depression (self-reported) 1.1 1.4 4.8 2.2 1.0 -0.1 0.8 0.3 1.6 0.5 1.7 -0.3
Medication: Lansoprazole 0.6 0.7 1.8 -0.5 -0.8 -1.3 1.0 0.8 0.7 -0.7 -0.7 -0.8
Prospective memory result 2.9 3.6 19.0 -0.2 0.7 1.0 -0.4 2.8 -0.3 4.4 -1.2 -1.6
Lung cancer (father) 2.7 3.2 6.6 0.4 2.0 1.8 -1.5 -2.2 -1.4 -1.5 1.9 2.6
Illnesses of mother 0.8 1.0 2.0 0.6 1.1 1.1 -1.0 -1.2 -0.9 -0.5 1.4 0.9
Forced expiratory volume in 1-second (FEV1), Best measure 3.7 12.0 28.3 1.2 3.8 3.4 -3.0 -5.3 -2.7 -2.6 4.2 3.2
Pulse wave Arterial Stiffness index 0.9 1.0 2.3 1.4 -0.6 -0.9 1.3 1.0 1.5 1.1 0.3 -0.3
Impedance of arm (left) 0.2 0.8 1.9 -0.9 -0.8 -1.4 0.5 1.0 0.5 -0.8 -0.8 -0.8
Arm fat mass (right) 1.4 5.6 24.1 -0.1 0.1 0.6 -0.0 3.5 -0.4 4.9 -2.8 -2.4
Trunk predicted mass 2.7 15.6 31.0 4.2 5.6 5.1 -2.9 -3.3 -2.2 1.7 4.7 4.0
Standing height 2.7 26.7 57.0 6.0 7.0 4.8 -2.7 -5.5 -1.3 -1.4 7.5 5.9
Length of working week for main job 1.4 1.5 3.9 1.2 1.5 1.3 -1.2 -1.4 0.0 0.3 2.0 0.8
Exposure to tobacco smoke at home 1.6 1.8 5.6 -2.0 -0.7 -0.6 0.2 1.3 -0.3 0.9 -1.7 -2.4
Breastfed as a baby 3.2 4.0 9.2 2.2 2.3 1.7 -0.8 -2.3 -0.5 -0.3 3.0 2.6
Tense / ‘highly strung’ 1.0 1.6 2.2 -1.5 -1.1 -1.4 1.3 1.4 1.0 0.1 -1.4 -1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 2.1 3.2 9.5 1.9 0.0 -1.6 1.3 2.8 3.1 0.9 0.4 -1.8
Hair/balding pattern: Pattern 4 2.8 6.8 11.8 1.3 -3.2 -2.9 3.2 3.3 3.4 1.9 -1.8 -0.0
Birth weight of first child 2.2 4.1 11.2 0.1 1.0 1.0 -1.4 -3.3 -1.6 -3.0 1.7 2.7
Peak expiratory flow (PEF) 1.2 2.7 6.1 1.5 1.0 1.4 -0.7 -2.5 -1.1 -1.3 1.8 2.5
Pulse wave reflection index 1.0 1.2 2.8 -0.4 -1.7 -0.9 1.4 1.1 0.5 1.0 -1.3 -0.9
Ever highly irritable/argumentative for 2 days 1.4 1.7 5.6 2.4 1.6 0.2 0.9 -0.6 0.9 0.8 2.1 0.1
Loud music exposure frequency 1.1 1.2 2.8 -1.7 -0.4 0.5 -1.1 0.5 -1.1 1.1 -1.7 -1.0
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 4.8 0.2 -1.1 -1.9 1.9 -0.3 0.9 -2.2 0.1 0.4
Mouth/teeth dental problems: Bleeding gums 5.5 7.1 24.3 -4.9 -0.9 0.4 -2.0 2.5 -1.7 1.1 -3.9 -3.1
Blood clot in the leg (DVT) 3.2 4.1 7.8 2.3 2.3 2.0 -2.2 -2.8 -0.4 -0.7 1.9 2.3
Medication: Paracetamol 0.3 0.5 1.3 0.8 -0.2 -0.6 1.1 -1.1 0.4 -1.0 0.5 0.0
Headache pain in last month 1.4 2.4 12.8 -1.3 -0.8 -1.4 0.9 -1.8 -0.2 -3.6 0.1 -0.2
Medication for cholesterol, blood pressure or diabetes 3.6 5.9 16.6 -0.5 1.8 1.6 -1.7 -4.1 -2.4 -3.2 2.3 2.5
Glaucoma (self-reported) 4.6 5.4 12.6 0.9 2.0 1.1 -1.3 -3.6 -1.1 -3.4 2.6 2.9
Gout (self-reported) 0.7 0.9 1.9 0.3 -0.4 -0.7 0.8 1.4 1.0 1.4 -0.4 -1.3
Hypothyroidism/myxoedema (self-reported) 1.2 2.4 8.8 0.8 -1.0 -0.7 0.5 2.5 0.9 3.0 -1.4 -1.2
Medication: Amlodipine 5.5 7.7 20.2 -0.0 -1.7 -2.2 2.5 4.5 2.7 3.5 -2.4 -3.2
Medication: Ventolin 100micrograms inhaler 0.5 0.6 2.1 1.4 -0.2 -0.7 0.4 0.3 1.3 -0.3 0.4 0.6
Birth weight 1.0 2.2 4.8 1.9 1.4 1.2 -0.1 -2.2 -0.6 -0.7 2.1 1.7
Chronic bronchitis/emphysema (mother) 0.9 1.1 2.3 1.2 1.1 1.2 -0.9 0.3 0.1 1.2 0.9 1.5
High blood pressure (siblings) 3.3 4.8 16.0 -1.3 -1.2 -0.7 0.3 2.6 0.8 3.0 -2.6 -4.0
Forced vital capacity (FVC), Best measure 5.1 18.5 33.1 2.5 5.3 4.7 -3.9 -5.8 -2.8 -1.9 5.7 4.3
Body fat percentage 2.1 8.4 20.9 -1.3 -1.5 -1.4 1.2 4.6 0.8 4.0 -4.1 -3.6
Leg fat percentage (right) 2.2 7.9 18.3 -2.3 -2.2 -1.8 1.4 3.9 0.8 2.7 -4.3 -3.7
Arm fat-free mass (right) 1.6 8.2 15.8 4.0 4.0 3.3 -1.6 -1.9 -0.8 1.9 3.4 3.0
Exposure to tobacco smoke outside home 2.0 2.7 8.4 -1.6 -0.6 -1.8 0.9 2.0 1.3 0.0 -1.6 -2.9
Comparative body size at age 10 3.1 8.5 47.1 1.1 1.0 1.0 -0.2 3.5 0.4 6.9 -1.6 -3.3
Number of full brothers 1.0 1.2 6.0 0.8 0.1 0.7 -0.6 1.1 0.6 2.5 -0.1 -1.4
Worry too long after embarrassment 0.3 0.5 1.3 0.5 -0.4 -1.0 1.2 0.9 0.6 0.4 -0.0 -1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 1.8 1.3 1.2 0.7 -0.7 0.1 0.4 0.1 1.2 0.7
Wheeze or whistling in the chest in last year 0.2 0.4 1.1 1.1 0.4 -0.5 0.1 0.7 1.0 0.7 0.0 -0.4
Number of children fathered 1.7 1.9 4.2 -0.6 1.4 2.1 -1.7 -1.0 -2.0 1.0 -0.5 1.2
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 4.1 0.8 0.6 0.4 0.0 1.2 0.5 2.0 0.2 -0.0
Age at first live birth 0.9 1.6 3.0 1.2 -1.2 -1.7 1.7 -0.8 1.2 -1.5 0.9 0.3
Pulse wave peak to peak time 1.0 1.2 2.5 -1.0 0.9 1.1 -1.4 -1.2 -1.6 -1.3 -0.0 0.7
Health satisfaction 0.5 0.7 1.7 0.9 -0.4 -0.9 0.7 1.1 1.3 0.8 -0.4 0.1
Shortness of breath walking on level ground 2.0 2.4 7.9 0.9 -0.6 -2.1 2.2 1.8 2.8 0.1 -0.0 -0.4
Qualifications: College or University degree 0.2 0.6 1.6 1.1 -0.5 -0.3 0.8 -0.2 1.3 -0.0 1.1 -0.5
Eye problems/disorders: None of the above 0.5 0.6 2.1 -0.5 -0.9 -1.0 0.5 -0.4 0.4 -1.5 -0.3 -0.7
Mouth/teeth dental problems: Loose teeth 0.6 0.7 2.5 0.3 0.5 0.2 -0.9 1.6 1.0 1.1 -0.1 -0.5
Emphysema/chronic bronchitis 0.3 0.3 0.9 0.5 0.8 0.4 -0.7 0.6 0.5 0.9 0.3 -0.3
Medication for pain relief, constipation, heartburn 0.7 1.2 2.4 1.3 1.4 1.0 -0.6 -0.1 -0.3 0.9 1.6 1.4
Neck or shoulder pain in last month 0.9 1.3 3.0 1.5 -0.1 -1.3 1.0 -0.8 1.7 -1.0 1.5 0.3
Medication: Blood pressure 7.0 12.3 26.7 -0.0 -2.8 -2.6 2.8 5.2 3.2 4.4 -3.7 -4.4
Angina (self-reported) 1.0 1.4 4.0 -0.8 -1.1 -2.0 1.3 0.9 1.3 -0.4 -1.4 -0.6
Migraine (self-reported) 3.4 4.2 9.4 2.2 0.9 0.5 -0.4 -3.0 0.3 -2.3 2.8 3.1
Medication: Ibuprofen 1.0 1.2 5.3 -0.5 -1.4 -1.1 0.8 -1.0 0.3 -2.3 -0.7 -0.3
Medication: Allopurinol 1.8 2.4 6.6 0.3 -0.8 -0.9 1.0 2.1 1.6 2.2 -0.7 -2.6
Medication: Omeprazole 0.4 0.5 1.5 -0.2 0.5 0.6 -0.8 -1.2 -1.0 -0.7 0.5 -0.4
Medication: Seretide 50 evohaler 0.7 0.8 2.4 1.0 1.3 0.5 -0.7 0.8 0.6 1.6 0.6 0.1
Mean time to correctly identify matches 7.0 13.4 32.8 0.0 4.7 5.7 -5.4 -1.5 -4.4 2.2 1.9 2.4
Heart disease (mother) 0.6 0.7 1.8 -1.3 -0.1 0.4 -1.0 0.7 -1.0 0.8 -1.1 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.7 3.5 0.3 -1.1 -1.5 1.1 1.6 1.9 0.8 -0.8 -1.8
Whole body fat mass 1.1 4.7 19.0 -0.0 0.1 0.1 0.4 3.4 0.2 4.4 -2.5 -2.3
Leg fat mass (right) 1.1 4.1 16.3 -0.1 -0.2 0.0 0.5 3.1 0.3 4.0 -2.4 -2.2
Arm predicted mass (right) 1.7 8.5 16.8 4.0 4.1 3.4 -1.6 -2.0 -0.9 2.0 3.4 3.1
Pulse rate, automated reading 1.9 6.3 14.4 3.5 2.7 1.5 -0.5 -2.3 0.1 -0.9 3.8 3.7
Alcohol intake frequency. 0.5 1.1 2.7 -0.7 0.7 0.8 -1.0 -1.6 -1.6 -1.3 -0.1 0.7
Comparative height size at age 10 3.4 18.6 38.4 5.0 6.2 4.5 -2.6 -4.0 -1.4 0.9 6.2 4.3
Number of full sisters 0.4 0.5 0.9 -0.3 0.0 0.9 -0.7 0.1 -0.9 1.0 -0.8 -0.8
Suffer from ‘nerves’ 3.3 5.2 14.4 0.8 -1.7 -3.3 2.7 0.3 3.1 -3.8 0.9 -0.1
Overall health rating 2.3 5.0 13.2 3.0 -0.6 -2.3 2.7 2.3 3.6 1.7 0.6 -1.2
Chest pain or discomfort 1.0 1.5 3.2 1.2 0.9 -0.8 1.1 -0.9 1.8 -1.3 1.8 0.6
Had major operations 1.5 1.8 5.4 0.6 -1.0 -2.0 1.8 1.2 2.3 -0.8 0.2 0.2
Age at last live birth 0.7 1.1 2.7 1.3 -0.2 -0.2 0.2 -1.6 0.2 -1.2 1.4 1.4
Family relationship satisfaction 0.4 0.5 1.5 0.9 0.6 0.4 -0.7 0.2 0.4 0.1 1.0 1.2
Leg pain on walking 0.8 1.0 3.1 1.8 0.2 -0.8 0.9 0.6 1.6 0.5 0.9 -0.0
Qualifications: NVQ or HND or HNC or equivalent 3.2 3.9 10.2 -1.2 1.8 2.2 -2.0 -2.6 -3.2 -1.4 0.3 1.4
Commuting to job workplace: Car/motor vehicle 4.2 4.8 7.6 -1.1 2.4 2.5 -2.8 -2.7 -2.4 -1.3 1.5 2.2
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.5 0.6 -0.7 -0.2 -0.0 0.7 -0.0 0.7 -0.5 0.0
Medication: Aspirin 1.1 1.5 4.2 0.1 -0.5 -0.6 0.7 2.0 1.4 1.9 -0.8 -1.3
Supplements: Vitamin C 1.4 1.6 4.0 -0.9 1.3 1.5 -2.0 -1.7 -1.2 -0.9 1.0 0.3
Knee pain experienced in last month 1.7 2.7 5.9 0.1 2.3 1.0 -0.8 -2.4 -0.4 -2.2 2.3 0.9
Hypertension (Self-reported) 12.4 34.4 66.6 -3.1 -5.5 -4.9 4.5 8.2 4.4 5.3 -7.1 -7.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.5 6.4 -0.9 0.4 0.1 -0.7 -1.7 -0.7 -2.5 1.0 1.1
Illnesses of father: Heart disease 1.1 1.5 3.1 0.9 -0.8 -1.4 1.4 1.7 1.7 1.2 -0.4 -0.5
Illnesses of siblings: Diabetes 0.8 1.0 3.0 -0.9 -0.3 0.0 -0.7 1.4 -0.0 1.1 -1.2 -1.7
Smoking status: Previous 0.8 1.2 3.6 1.0 1.4 1.5 -1.2 0.3 -0.2 1.9 0.7 0.1
Forced expiratory volume in 1-second (FEV1), predicted 4.5 9.3 16.0 1.8 3.7 3.5 -3.2 -4.0 -2.0 -1.3 4.0 2.7
Whole body fat-free mass 2.0 11.6 24.4 4.0 4.9 4.5 -2.4 -2.1 -1.9 2.8 3.6 3.1
Leg fat-free mass (right) 1.6 8.4 20.1 3.6 4.0 3.7 -1.6 -0.3 -1.5 4.5 2.2 1.6
Arm fat percentage (left) 2.7 10.8 28.0 -1.4 -1.6 -1.0 0.9 5.0 0.3 5.3 -4.7 -4.0
Average weekly red wine intake 0.1 0.1 0.6 0.1 -0.7 0.1 -0.2 -0.3 -0.4 -0.1 -0.7 0.2
Handedness (chirality/laterality): Left-handed 0.2 0.3 0.7 -0.5 -0.2 0.2 -0.6 0.8 -0.3 -0.6 -0.8 -0.2
Mood swings 4.5 8.2 15.4 -1.1 -3.4 -3.9 3.6 2.7 3.1 -0.7 -2.7 -2.8
Loneliness, isolation 3.0 4.1 10.2 1.3 -1.2 -3.0 3.0 1.1 3.2 -1.9 0.5 -0.0
Long-standing illness, disability or infirmity 1.7 2.5 7.1 2.7 2.0 0.8 -0.2 0.3 1.2 2.4 1.9 0.7
Ever had bowel cancer screening 0.9 1.0 2.5 -0.6 0.3 0.6 -1.0 -1.1 -1.3 -1.4 -0.0 1.6
Diabetes diagnosed by doctor 0.1 0.2 0.6 0.8 0.6 0.1 0.4 0.1 -0.5 0.4 -0.4 0.7
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 3.3 -0.8 -0.2 0.2 -0.7 -1.6 -1.6 -1.8 -0.0 1.3
Friendships satisfaction 1.6 2.0 6.8 2.6 0.6 -0.3 0.7 -0.1 1.5 -0.2 2.0 2.0
Qualifications: nursing, teaching 1.3 2.0 4.2 0.9 -1.5 -1.0 1.7 2.1 1.4 2.0 -0.7 -0.5
Commuting to job workplace: Walk 2.4 2.6 6.2 0.9 -1.5 -2.1 2.5 1.5 2.3 0.1 -1.0 -1.2
Eye problems/disorders: Cataract 0.9 1.0 4.4 1.6 0.5 0.5 0.4 1.1 0.6 2.1 0.4 0.4
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 3.6 -0.8 0.5 1.2 -1.5 0.6 -0.3 1.9 -0.5 -1.7
Medication for cholesterol 2.9 4.4 9.4 0.9 1.9 1.0 -1.5 -3.1 -0.9 -2.7 2.9 2.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.1 2.5 4.9 -1.5 0.9 1.8 -2.2 0.8 -1.6 1.9 -1.3 -1.6
Back pain experienced in last month 1.5 2.2 5.0 0.2 -1.8 -2.2 2.1 -0.2 1.7 -1.9 -0.2 -0.6
Mineral and other dietary supplements 0.1 0.2 0.7 0.2 0.8 -0.0 0.3 -0.1 0.3 -0.0 0.2 -0.9
Breast cancer (self-reported) 0.3 0.4 1.1 -0.3 0.6 0.6 -1.1 -0.4 -1.1 0.0 0.2 0.4
Asthma (self-reported) 1.2 2.3 5.6 0.4 -1.6 -1.9 1.4 1.6 2.4 0.5 -1.0 -1.7
Osteoporosis (self-reported) 2.6 3.3 9.3 0.4 -2.1 -3.1 2.9 0.6 2.0 -1.6 -0.1 -0.4
Osteoarthritis (self-reported) 0.7 1.0 3.1 1.8 -0.2 -1.0 1.6 0.2 0.9 0.2 0.3 1.0
Medication: Aspirin 0.7 1.0 3.5 0.1 -0.3 -0.2 0.4 1.8 0.5 1.9 -1.0 -0.7
Medication: Gliclazide 0.6 0.7 2.0 0.7 1.4 0.4 -0.5 0.8 0.2 1.4 0.7 -0.3
Illnesses of father: None of the above (group 1) 3.1 3.8 6.6 -0.9 2.0 1.8 -2.2 -2.6 -1.9 -2.2 1.7 1.9
Smoking status: Current 1.0 1.6 5.1 2.2 1.0 -0.0 0.0 -0.3 1.7 -0.4 1.7 1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.2 2.5 5.5 -2.0 0.9 1.6 -2.3 -2.0 -2.3 -0.7 -0.0 -0.4
Whole body water mass 2.0 11.6 24.0 4.0 4.9 4.5 -2.4 -2.2 -1.9 2.6 3.6 3.1
Leg predicted mass (right) 1.6 8.4 19.5 3.5 4.1 3.7 -1.8 -0.3 -1.6 4.4 2.2 1.6
Arm fat mass (left) 1.2 5.1 23.8 0.2 0.3 0.6 0.1 3.3 -0.3 4.9 -2.6 -2.0
Number of self-reported non-cancer illnesses 3.4 5.8 14.4 1.9 -2.1 -3.0 3.0 2.8 3.8 1.0 -0.7 -1.5
Average weekly champagne plus white wine intake 1.0 1.4 5.3 -1.9 0.6 0.3 -1.0 -1.4 -0.7 -2.3 -0.1 0.1
Miserableness 9.3 16.1 33.1 -0.5 -5.0 -5.8 5.6 3.4 4.6 -0.9 -3.2 -3.5
Guilty feelings 3.7 5.5 10.8 1.4 -1.4 -2.0 2.9 2.9 3.3 2.4 -1.0 -2.7
Wears glasses or contact lenses 0.4 0.5 2.5 0.7 0.2 0.3 0.5 0.7 -0.1 1.6 -0.3 0.2
Ever taken oral contraceptive pill 2.0 2.3 6.0 0.9 0.0 -0.7 1.3 -2.0 0.1 -2.4 1.5 2.3
Hearing aid user 1.0 1.1 2.6 -1.3 0.1 -0.1 -0.2 1.6 0.4 1.5 -1.2 -1.3
Mother’s age at death 1.0 1.2 4.0 -1.9 -0.8 -1.1 0.8 -0.5 -0.1 -2.0 -0.3 -0.6
Financial situation satisfaction 0.9 1.1 3.7 1.0 0.9 0.0 -0.4 -0.4 0.5 -1.0 1.9 1.6
Tinnitus: Yes, now most or all of the time 0.3 0.4 1.3 -1.2 -0.6 -0.4 0.3 -0.2 -0.8 -0.8 -0.6 0.0
Commuting to job workplace: Public transport 0.8 0.9 1.5 0.8 -1.2 -0.9 1.0 1.2 0.9 0.9 -0.7 -1.0
Eye problems/disorders: Glaucoma 6.8 8.0 21.1 2.0 2.5 1.2 -1.2 -3.6 -0.9 -3.7 3.3 4.6
Medication: Blood pressure 6.6 12.5 25.9 -3.5 -3.5 -2.6 2.0 4.5 1.4 2.6 -5.1 -4.8
Pain type(s) experienced in last month: Hip pain 0.6 0.8 2.5 1.6 -0.4 -0.9 1.3 -0.0 1.1 0.5 0.6 0.6
Supplements: Fish oil (including cod liver oil) 0.4 0.6 1.6 -0.3 0.4 1.1 -1.0 0.1 -1.0 1.3 -0.1 0.4
High cholesterol (Self-reported) 1.2 2.1 7.3 0.1 -1.5 -1.4 1.0 2.7 1.1 1.1 -1.5 -1.3
Medication: Bendroflumethiazide 6.7 10.2 17.1 -1.8 -3.3 -3.0 2.7 4.1 2.1 2.5 -4.1 -4.0
Medication: Paracetamol 0.3 0.4 1.2 1.0 0.1 -0.2 0.9 -1.1 0.2 -0.6 0.5 0.5
Medication: Lisinopril 6.0 7.7 15.7 -1.0 -3.1 -2.6 2.1 4.0 2.4 1.5 -3.8 -3.1
Medication: Atorvastatin 0.5 0.6 1.8 0.1 0.3 0.6 -0.4 1.1 -0.4 1.3 -1.0 -0.6
Illnesses of father: High blood pressure 1.7 2.1 5.2 -1.4 -0.7 -0.3 0.3 1.9 0.6 1.9 -1.8 -2.3
Alcohol drinker status: Never 0.4 0.5 1.4 -0.7 -0.9 -0.5 -0.0 0.3 0.2 -0.3 -1.2 -1.2
Ever smoked 0.9 1.6 5.7 2.4 0.8 0.7 -0.4 0.5 1.4 1.6 1.3 0.7
Basal metabolic rate 1.6 8.7 19.4 3.5 4.4 3.9 -2.0 -1.3 -1.6 3.1 2.8 2.2
Leg fat percentage (left) 2.3 8.2 17.6 -2.0 -1.9 -1.5 1.2 4.2 0.8 3.3 -4.2 -3.8
Arm fat-free mass (left) 1.5 7.6 16.2 3.5 4.0 3.3 -1.7 -1.9 -1.2 1.8 3.2 2.7
Number of operations (self-reported) 0.5 0.7 2.6 0.3 0.2 -0.2 0.0 -0.9 0.4 -1.5 0.8 1.6
Average weekly beer plus cider intake 1.9 2.7 8.2 1.3 2.9 2.2 -1.7 -0.6 -0.2 1.2 2.2 0.7
Irritability 0.3 0.5 1.7 -0.1 -0.4 -0.9 0.6 -0.2 1.0 -1.3 -0.3 -0.6
Risk taking 1.9 2.8 5.4 1.4 2.3 2.1 -1.5 -1.0 -0.9 1.1 2.3 1.8
Ever had prostate specific antigen (PSA) test 1.6 1.8 4.6 1.0 -1.0 -1.8 2.0 1.4 2.1 0.5 0.0 -0.4
Fractured/broken bones in last 5 years 1.0 1.3 2.5 -0.2 -1.6 -1.6 1.5 1.1 1.5 -0.9 -0.5 -0.4
Age started oral contraceptive pill 0.8 1.0 2.4 -1.1 -1.4 -1.6 1.3 0.4 0.2 -1.1 -0.5 0.2
Diastolic blood pressure, automated reading 3.7 11.6 24.9 0.3 -2.8 -2.2 2.7 5.0 3.6 4.2 -2.8 -4.6
Ever depressed for a whole week 0.5 0.6 1.9 0.7 1.4 1.1 -0.8 -0.0 -0.5 0.2 0.7 -0.3
Unable to work because of sickness or disability 1.5 1.9 6.2 2.5 1.4 0.5 0.4 0.6 1.3 2.2 1.4 0.4
Commuting to job workplace: Cycle 0.4 0.5 1.2 -0.2 -1.1 -0.2 0.5 0.7 -0.3 1.0 -1.0 -0.6
Myopia 2.5 3.6 10.9 1.7 2.7 1.5 -0.8 -1.8 0.3 -0.9 3.3 2.2
Vascular/heart problems diagnosed by doctor 11.2 30.6 59.8 2.4 5.5 4.8 -4.4 -7.7 -4.5 -4.8 6.6 7.1
Cholesterol lowering medication 2.2 3.2 8.5 -1.3 -2.4 -1.8 1.4 1.9 0.3 0.0 -2.9 -2.1
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.4 -0.7 0.5 0.4 -0.6 -1.2 -0.9 -1.0 0.2 -0.9
Pain experienced in last month 1.5 2.5 8.1 0.7 1.4 2.4 -1.9 0.3 -1.5 2.8 -0.0 0.2
Supplements: Calcium 1.3 1.4 3.3 1.8 0.2 -1.2 1.0 -0.3 1.6 -0.7 1.8 1.0
Basal cell carcinoma (self-reported) 2.1 2.5 5.8 -0.3 -1.2 -1.0 0.8 2.4 1.2 2.4 -1.1 -2.3
Heart attack/myocardial infarction (self-reported) 0.8 1.0 4.8 2.2 0.6 -0.2 0.6 0.4 1.1 0.7 0.7 1.0
Deep venous thrombosis (DVT) (self-reported) 3.2 4.1 7.2 2.1 2.5 2.2 -2.4 -2.7 -0.6 -0.2 1.9 2.0
Heart disease (siblings) 0.7 0.8 2.4 0.5 1.6 1.3 -1.3 -0.2 -0.6 0.4 0.8 0.4
Alcohol drinker status: Previous 0.8 0.9 1.9 1.2 -0.2 -1.1 1.2 1.3 1.4 0.0 -0.4 -0.5
Pack years of smoking 1.4 2.0 4.4 1.9 2.0 1.0 -0.1 1.1 1.3 2.1 1.5 0.0
Impedance of whole body 0.6 3.0 11.5 -1.6 -1.8 -2.5 1.0 0.0 1.2 -3.4 -0.7 -0.6
Leg fat mass (left) 1.1 4.3 19.6 0.1 0.3 0.4 0.2 3.1 0.2 4.4 -2.2 -2.1
Arm predicted mass (left) 1.4 6.9 14.8 3.3 3.9 3.2 -1.7 -1.9 -1.2 1.5 3.0 2.7