Hub : Genes

CKAP5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.0870	0.0380	0.00015	0.118	NA	0.056	NA	0.069	4.9e-07	NA	0.00051	NA	0.00012
2	GTEx	Brain Putamen basal ganglia	0.2460	0.1110	0.00800	0.068	NA	0.076	NA	0.135	1.1e-02	NA	0.00740	NA	0.00045
3	GTEx	Breast Mammary Tissue	0.0850	0.0380	0.00043	0.045	NA	0.028	NA	0.018	2.2e-03	NA	0.01300	NA	0.04000
4	GTEx	Breast Mammary Tissue (Female)	0.0546	0.0874	0.34000	0.071	NA	0.002	NA	0.032	3.8e-03	NA	0.28000	NA	0.04000
5	GTEx	Esophagus Gastroesophageal Junction	0.1120	0.0530	0.00048	0.040	NA	0.022	NA	0.035	1.4e-02	NA	0.05200	NA	0.02100
6	GTEx	Esophagus Muscularis	0.0530	0.0280	0.00250	0.025	NA	0.033	NA	0.035	1.1e-02	NA	0.00420	NA	0.00330
7	YFS	Blood	0.0128	0.0105	0.03900	0.005	0.004	0.003	0.006	0.004	6.5e-03	0.0150	0.03700	0.0036	0.01100
8	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0860	0.0570	0.00094	0.005	0.038	0.012	NA	0.017	1.5e-01	0.0029	0.06100	NA	0.03400

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8
Bipolar Disorder (2018)	1.2	1.9	3.4	1.3	1.8	1.1	-1.2	1.6	0.9	-1.8	1.0
Bipolar Disorder or Schizophrenia	3.1	7.5	16.3	1.8	2.3	1.0	-3.3	2.5	2.4	-3.4	4.0
Depressed Affect (Nagel 2018)	7.1	14.9	34.6	-5.5	-1.3	-3.1	0.1	-4.5	-5.9	-2.1	-4.3
Depression (Nagel 2018)	4.5	6.8	16.2	-3.6	-0.1	-2.3	-1.5	-1.7	-4.0	-1.3	-3.6
Intelligence (Savage-Jansen 2018)	1.8	5.5	19.9	-1.5	3.6	1.5	0.9	0.4	-2.4	0.2	-4.5
Neuroticism (Nagel 2018)	5.5	12.9	28.8	-5.1	-1.6	-2.5	1.0	-4.4	-5.4	-1.6	-4.1
Schizophrenia (2018)	3.1	6.5	19.8	1.3	1.4	0.3	-3.3	2.0	2.3	-2.9	4.4
Schizophrenia vs Biploar Disorder	3.2	4.3	13.5	1.2	1.8	0.6	-2.3	1.8	2.4	-1.1	3.7
Worry (Nagel 2018)	2.5	5.2	9.5	-3.1	0.3	-0.4	2.1	-2.4	-3.1	-2.5	-2.5
Alzheimer’s Disease (in mother)	0.9	1.0	1.9	0.9	0.8	1.4	0.2	-0.4	1.3	-1.0	1.4
Alzheimer’s Disease (in father)	0.4	0.4	1.2	-0.2	1.1	-0.1	0.2	0.8	-0.5	-0.5	-0.8
Alzheimer’s Disease (including proxy)	0.7	1.1	3.1	0.7	1.6	1.1	0.8	-0.2	0.6	-1.8	0.4
Crohns Disease (2017)	0.2	0.5	2.8	-0.2	-1.7	-0.3	-0.0	0.1	0.1	0.9	0.1
Irritable Bowel Disease (IBD)	0.1	0.3	0.9	-0.5	-0.8	-0.3	0.1	0.4	-0.1	1.0	-0.4
Ulcerative Colitis (UC)	0.0	0.1	0.4	-0.2	-0.2	-0.1	0.4	0.2	0.2	0.6	0.2
Major Depression (MDD)	0.3	0.3	1.1	-1.1	-0.4	-0.7	0.3	-0.5	-0.7	-0.2	-0.2
Reaction Time	9.0	17.2	35.0	4.3	3.8	3.2	-2.1	4.3	5.4	-2.7	5.9
Verbal and Numeric Reasoning (VNR)	2.2	5.4	20.1	-2.0	3.2	0.5	0.1	0.2	-2.8	-0.6	-4.5
Breast Cancer	0.8	2.0	5.5	-0.4	0.1	0.8	2.4	-2.3	-0.5	-1.9	0.0
Ovarian Cancer	0.5	0.6	1.4	0.8	0.5	0.6	0.6	0.7	0.3	1.2	-1.0
Prostate Cancer	1.3	1.8	5.2	0.6	0.5	1.9	2.3	-2.2	-0.2	0.3	-0.3
Age at First Birth	1.0	1.5	2.8	-1.5	-1.2	-0.8	1.5	-0.7	-1.4	0.2	-1.7
Bipolar Disorder (2011)	1.4	1.4	2.0	1.3	0.9	1.1	1.3	1.3	1.4	-1.1	0.9
Body Mass Index (BMI) (2010)	2.0	2.7	7.4	-1.1	-2.7	-2.5	-1.2	-1.0	-0.4	2.0	0.7
Coronary Artery Disease (CAD)	0.4	0.5	2.3	0.1	-1.5	-0.8	-0.5	-0.1	0.0	-0.5	0.9
Crohns Disease (2012)	0.3	0.5	1.2	0.2	-0.9	-0.3	-0.5	0.6	0.6	1.0	1.1
Mean Putamen Volume	2.2	2.6	9.9	1.5	0.6	1.5	0.0	0.5	2.2	-0.9	3.1
Fasting Glucose	4.0	4.8	19.4	1.9	3.1	1.1	-1.2	4.4	1.6	0.6	0.1
HbA1C	0.2	0.2	1.3	0.3	0.1	0.4	-0.1	0.5	-0.1	-0.4	-1.1
HDL Cholesterol	13.0	21.8	63.3	4.6	8.0	5.4	0.8	6.0	2.8	-3.6	-1.2
LDL Cholesterol	2.4	3.7	8.3	-1.8	-1.6	-0.8	0.9	-2.7	-2.2	1.5	-2.9
Lupus	0.8	1.2	5.3	0.0	1.2	0.3	-0.1	1.2	-0.9	-0.6	-2.3
Neuroticism (2016)	3.5	5.1	11.9	-2.9	-0.9	-1.4	-0.2	-2.2	-3.5	-1.1	-3.5
Primary Biliary Cirrhosis	2.3	3.3	6.7	0.9	2.0	0.6	-2.0	2.5	1.1	-2.6	1.7
Rheumatoid Arthritis	2.2	3.0	9.9	0.1	-1.4	0.5	3.1	-1.5	-0.3	3.1	-0.4
Schizophrenia (2014)	3.9	8.6	20.6	1.7	2.7	0.9	-3.1	3.0	2.6	-3.4	4.5
Triglycerides	4.6	7.6	17.4	-3.1	-3.0	-1.2	2.3	-4.2	-2.4	2.9	-1.8
Type 2 Diabetes (T2D) (2012)	1.3	1.5	2.9	1.6	1.4	1.5	0.9	0.7	1.7	0.1	1.2
Ulcerative Colitis	0.4	0.6	2.9	-0.5	-0.5	-0.1	1.2	-0.4	-0.1	1.7	-0.2
Blood Eosinophil Count	0.4	3.1	9.0	3.0	-0.4	2.2	0.8	-0.4	2.2	-1.1	1.9
Blood Platelet Count	1.6	18.5	59.8	-0.4	5.9	0.4	-2.8	6.7	-0.9	-7.7	-0.2
Blood Red Count	0.0	0.3	1.7	1.3	-0.2	0.1	0.8	-0.1	0.5	-0.4	0.1
Blood White Count	0.9	6.4	21.9	1.6	-4.7	-1.7	0.8	-2.3	1.7	2.6	2.8
Heel T-Score	17.2	137.1	240.2	14.7	11.2	9.1	-5.0	15.5	14.7	-7.2	11.8
BMI	1.7	9.8	31.8	-0.1	-5.6	-3.4	-1.7	-1.4	1.5	2.8	4.4
Height	1.7	33.0	93.9	3.3	9.7	4.7	-1.6	8.2	2.0	-7.9	-0.3
Waist Hip Ratio (WHR)	0.7	3.1	9.4	-1.4	2.5	0.0	-0.1	1.4	-1.9	-1.3	-3.1
Systolic Blood Pressure	4.4	22.2	36.0	-6.0	-4.6	-5.4	-0.2	-4.8	-5.6	-5.7	-2.1
Smoking Status	3.2	7.7	17.9	1.6	3.4	0.6	-3.5	3.1	1.6	-4.2	2.3
Allergy or Eczema	0.4	1.0	2.8	0.6	0.4	1.7	1.2	-1.6	0.6	-0.8	0.4
Cardiovascular Disease	2.9	9.6	18.5	-2.8	-4.3	-3.4	-1.2	-4.3	-1.6	-3.1	2.5
Hypothyroidism (self reported)	0.9	2.1	6.5	-0.6	-0.9	-2.6	-2.2	0.6	-0.2	-1.1	1.7
Respiratory disease	1.1	2.5	5.3	-2.2	-0.4	-1.2	-0.6	-1.3	-2.2	-2.3	-1.3
Type 2 Diabetes (T2D) (2018)	0.5	1.0	3.2	0.3	-0.6	-0.3	-0.9	-1.3	0.3	1.8	1.2
Lung FEV1/FVC ratio	0.4	2.3	6.1	1.4	-0.6	1.5	2.1	-1.3	1.0	2.5	-0.6
Lung FVC	1.3	6.8	11.4	3.2	3.2	3.4	0.1	3.2	2.9	-1.7	1.0
Neuroticism	5.7	13.9	33.6	-5.4	-1.2	-2.9	0.4	-3.8	-5.8	-2.0	-4.5
Chronotype (morning person)	1.2	2.9	10.8	0.1	-2.5	-1.1	-0.3	-0.7	1.6	-1.1	3.3
Hair Pigment	0.6	16.6	42.9	4.0	6.5	4.7	0.1	5.6	2.8	-3.5	-0.1
Tanning	0.4	4.6	8.6	1.9	2.6	2.9	1.6	1.1	2.1	-1.9	2.5
Hand grip strength (left)	2.0	5.2	16.8	1.3	3.2	1.9	-1.0	2.4	1.2	-4.1	0.9
Number of treatments/medications taken	3.6	6.5	11.4	-3.4	-3.3	-3.2	-0.7	-2.1	-3.2	0.2	-2.1
Average weekly spirits intake	1.1	1.4	4.8	-0.4	-0.3	-1.1	-2.2	0.9	-0.4	-1.9	-0.2
Sensitivity / hurt feelings	2.9	4.9	10.2	-2.3	-2.7	-1.4	1.3	-3.2	-2.3	2.1	-1.8
Frequency of depressed mood in last 2 weeks	5.0	7.0	17.1	-3.7	-0.1	-1.8	-0.8	-2.2	-4.1	-1.4	-3.8
Hearing difficulty/problems: Yes	0.3	0.5	2.5	0.2	-0.2	-0.0	-0.7	0.1	-0.8	0.3	-1.6
Relative age of first facial hair	0.9	1.9	3.3	1.8	1.8	1.1	-0.4	1.6	1.5	-1.6	0.8
Other serious medical condition/disability diagnosed by doctor	1.9	2.4	7.7	-1.1	-0.1	-1.9	-2.8	1.8	-0.8	-1.5	-0.9
Ever used hormone-replacement therapy (HRT)	3.7	4.8	10.4	-2.7	-2.8	-3.2	-0.5	-1.5	-2.5	1.2	-1.7
Ever had hysterectomy (womb removed)	2.8	3.2	7.2	-1.4	-1.7	-1.3	1.7	-1.4	-1.5	2.1	-2.7
Systolic blood pressure, automated reading	4.3	12.5	26.2	-4.3	-3.8	-5.1	-2.1	-2.4	-3.9	-3.8	-1.0
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	3.1	0.4	-1.2	-0.8	-1.4	-0.5	1.0	0.9	1.8
Angina	1.6	2.1	4.8	-1.6	-1.6	-1.6	-0.2	-2.2	-1.6	0.1	-1.0
Medication for hormone replacement therapy	1.3	1.4	6.1	0.3	1.4	-0.5	-1.5	2.5	0.3	-0.8	0.3
Vitamin and mineral supplements	0.1	0.2	1.2	-0.3	0.3	0.0	0.0	-1.1	-0.1	-0.4	0.0
Supplements: Zinc	1.0	1.1	3.3	1.1	0.9	0.7	-0.6	1.8	1.3	0.0	1.1
Medication: Co-codamol	2.0	2.3	5.3	-1.5	-0.2	-2.3	-1.9	0.1	-1.5	-1.0	-1.9
Medication: Metformin	1.0	1.5	5.9	0.2	-0.2	-0.9	-2.4	0.4	0.9	1.3	1.5
Diabetes (father)	1.0	1.2	3.8	-0.2	-1.9	-0.1	1.5	-1.2	-0.0	1.5	0.2
Diabetes (mother)	0.4	0.5	1.8	-0.1	0.4	-0.2	1.0	-0.8	-0.4	1.3	-0.7
Severe depression (siblings)	4.0	4.5	12.4	2.6	1.9	3.5	1.8	1.4	2.4	-1.0	1.2
Pack years adult smoking proportion	1.2	1.8	5.6	-0.3	0.4	-0.7	-2.4	1.8	0.1	-1.6	1.4
Impedance of leg (right)	0.7	3.6	6.6	-0.9	2.6	1.4	2.2	-2.2	-1.5	-1.0	-2.5
Leg fat-free mass (left)	1.1	5.6	14.3	2.0	0.3	-0.1	-3.0	3.8	2.4	-1.8	2.8
Trunk fat percentage	1.6	6.4	17.1	-1.5	-4.1	-4.1	-1.7	-2.2	-0.3	1.4	2.3
Hand grip strength (right)	1.5	4.0	18.8	0.9	2.3	1.0	-1.7	1.5	0.6	-4.3	0.6
Townsend deprivation index at recruitment	2.4	3.3	8.6	-2.2	0.9	-1.0	-2.2	0.5	-2.0	-2.9	-1.3
Current tobacco smoking	1.7	2.8	8.9	-0.4	2.5	-0.2	-2.3	1.3	-0.7	-3.0	-0.0
Average weekly fortified wine intake	0.8	1.0	2.3	-1.1	0.1	-0.5	1.0	-0.0	-1.2	1.5	-1.3
Maternal smoking around birth	0.7	1.0	2.3	-1.3	-0.3	-1.5	-0.7	0.1	-0.5	-1.3	1.3
Fed-up feelings	8.4	15.2	33.5	-5.4	-2.4	-4.0	-0.8	-4.0	-5.8	-1.0	-4.4
Frequency of unenthusiasm / disinterest in last 2 weeks	3.7	5.0	10.4	-2.6	-0.7	-2.2	-2.2	-0.9	-3.2	-1.9	-2.9
Relative age voice broke	1.2	1.8	3.5	1.9	1.4	1.4	0.4	1.6	1.7	-0.3	1.0
Taking other prescription medications	1.1	1.7	5.7	-1.0	-0.3	-2.0	-2.4	1.2	-0.7	-0.5	-0.3
Age when periods started (menarche)	1.4	3.3	9.7	0.4	3.1	3.1	1.5	-0.8	-0.3	0.2	-2.1
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	3.2	-1.8	-1.1	-1.4	0.1	-1.0	-1.6	0.7	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	11.6	26.2	48.7	6.1	4.8	3.7	-2.3	7.0	6.2	-4.0	5.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	-0.1	-0.5	-0.2	0.3	-0.6	-0.3	-0.1	-0.2
Qualifications: CSEs or equivalent	0.2	0.3	0.6	-0.6	-0.6	-0.3	0.4	-0.4	-0.5	0.8	-0.4
Serious illness, injury or assault to yourself	0.2	0.2	0.7	-0.2	0.1	-0.2	0.7	0.4	0.0	0.8	-0.5
High blood pressure	5.7	15.9	39.6	-4.4	-5.7	-4.3	0.0	-6.3	-3.3	-2.4	0.6
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.9	-0.1	0.7	1.0	0.4	-1.4	0.2	-0.8	0.1
Multivitamins +/- minerals	0.5	0.7	2.0	-1.1	-0.1	-0.4	-0.0	0.2	-1.3	0.3	-1.4
Stomach or abdominal pain in last month	0.8	1.0	1.7	1.1	1.3	1.3	-0.1	0.8	1.0	-1.2	0.6
Supplements: Glucosamine	1.7	2.2	5.3	2.3	0.2	1.4	0.4	2.2	1.9	-0.1	1.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.3	0.1	0.4	-0.5	1.1	0.5	-0.3	0.1	-0.7
Medication: Atenolol	1.0	1.2	3.3	0.3	0.3	0.2	-1.8	0.4	1.0	-1.6	1.5
Medication: Levothyroxine sodium	1.5	2.5	8.2	-0.9	-2.3	-2.9	-2.1	-0.3	-0.8	0.5	0.5
Sitting height	2.3	16.6	32.7	3.6	5.2	3.6	-0.8	5.7	3.2	-5.7	2.0
Chronic bronchitis/emphysema (father)	2.3	2.7	11.6	-0.8	0.5	-1.0	-2.5	1.1	-0.4	-3.4	0.8
High blood pressure (mother)	1.7	2.4	6.2	-1.5	-2.2	-0.7	1.2	-2.5	-1.6	-1.3	-0.1
Body mass index (BMI)	1.6	6.7	21.2	-0.8	-4.6	-3.8	-2.4	-1.2	0.4	1.5	2.8
Impedance of leg (left)	0.8	3.7	7.6	-0.9	2.5	1.4	2.8	-2.1	-1.5	-0.8	-2.3
Leg predicted mass (left)	1.1	5.6	13.6	2.1	0.1	-0.1	-3.1	3.7	2.5	-1.7	2.9
Trunk fat mass	0.9	4.0	9.7	-0.5	-3.0	-3.1	-2.1	-0.6	0.6	0.3	2.8
Waist circumference	1.0	3.8	11.6	-1.7	-2.9	-3.4	-2.2	-0.6	-1.0	1.0	0.6
Number of incorrect matches in round	3.0	5.0	11.0	3.3	0.8	2.6	2.5	1.4	3.2	1.0	1.5
Past tobacco smoking	1.8	3.4	10.9	-0.6	-0.6	0.8	3.3	-2.2	-0.8	2.5	-1.6
Alcohol usually taken with meals	1.7	2.7	7.8	0.5	-0.5	0.9	2.8	-1.9	-0.6	2.3	-1.8
Nervous feelings	2.2	4.2	12.2	-2.5	-0.8	-0.1	2.6	-3.5	-2.3	-1.0	-1.3
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.7	5.9	-2.4	0.4	-0.8	-0.8	-0.8	-2.4	-2.0	-1.9
Hearing difficulty/problems with background noise	6.6	10.6	23.6	-4.2	-2.4	-3.0	0.5	-3.1	-4.9	1.1	-4.2
Hair/balding pattern: Pattern 2	1.7	2.1	4.6	1.1	1.6	1.2	-1.5	1.8	1.1	-2.1	0.6
Had menopause	0.8	0.9	3.2	-0.5	1.0	-1.0	-1.8	1.0	-0.6	-0.9	-0.3
Had other major operations	0.3	0.4	1.1	0.2	1.1	0.7	0.3	-0.4	-0.3	-0.2	-1.0
Forced vital capacity (FVC)	3.0	11.4	27.0	3.0	5.2	4.1	0.2	4.7	2.3	-3.3	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	12.4	28.3	53.7	6.5	5.2	4.1	-2.5	7.3	6.5	-3.7	5.0
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	4.6	1.2	1.8	0.9	-0.9	2.2	1.3	-1.8	1.0
Qualifications: None of the above	0.8	1.7	8.0	-0.8	-0.7	-0.8	-0.6	-1.5	-0.5	-2.8	1.0
Financial difficulties in last 2 years	1.4	1.8	4.5	-1.9	-0.0	-1.3	-2.1	-0.0	-1.7	-0.7	-1.3
Mouth/teeth dental problems	2.0	3.0	11.2	-1.7	-0.7	-1.5	-0.9	0.8	-2.4	0.6	-3.3
Heart attack	1.2	1.6	3.7	-1.2	-0.2	-1.9	-1.9	0.2	-1.2	-1.6	-0.5
Allergy	0.3	0.7	3.0	-0.0	-0.8	-0.8	0.1	1.1	-0.0	1.7	-0.2
Pain all over the body in last month	0.6	0.6	1.9	-0.4	-0.6	-1.4	-1.2	0.4	-0.3	-0.7	0.3
Diabetes (self-reported)	1.0	1.6	7.3	-0.2	-0.9	-1.5	-2.7	-0.4	0.1	1.2	0.7
Hayfever/allergic rhinitis (self-reported)	3.3	4.4	9.1	-2.8	-0.6	-2.0	0.4	-2.4	-3.0	1.7	-2.3
Medication: Ramipril	0.8	1.0	3.8	-0.4	-1.1	0.1	-0.3	-0.6	0.1	-1.9	1.6
Medication: Simvastatin	2.0	3.0	7.6	-2.4	-1.3	-2.8	-1.3	-1.4	-2.1	-0.2	-0.9
Fluid intelligence score	1.9	4.0	13.4	-1.1	3.3	1.4	0.9	0.4	-1.9	-0.5	-3.7
Illnesses of siblings	1.4	1.9	5.5	0.6	1.0	1.4	1.1	0.6	-0.3	2.2	-2.4
Neuroticism score	4.3	8.9	21.2	-4.2	-0.6	-2.0	-0.1	-3.0	-4.6	-2.7	-3.5
Weight	0.6	2.9	6.8	0.7	-1.1	-1.6	-2.6	1.8	1.3	-1.2	2.5
Impedance of arm (right)	0.1	0.5	2.0	-0.7	0.3	-0.3	1.1	-1.4	-0.1	0.4	-0.1
Arm fat percentage (right)	2.2	8.5	25.0	-1.3	-5.0	-4.4	-2.2	-2.0	0.3	2.0	3.1
Trunk fat-free mass	2.1	12.0	33.3	3.4	3.5	2.8	-2.4	5.8	3.1	-3.5	2.0
Hip circumference	1.5	6.3	21.8	-1.7	-4.7	-3.8	-1.8	-1.8	-0.9	2.0	0.8
Time employed in main current job	2.6	3.1	6.7	1.4	2.1	2.6	2.4	1.6	1.8	0.1	0.3
Alcohol intake versus 10 years previously	0.5	0.7	2.3	1.1	-0.5	0.2	0.4	-0.3	1.5	0.4	1.3
Father’s age at death	1.3	1.7	3.9	-1.1	-1.1	-0.4	2.0	-1.8	-0.8	1.5	-1.2
Worrier / anxious feelings	0.6	1.1	3.1	-0.9	0.1	0.5	1.7	-0.9	-0.8	-1.8	0.1
Frequency of tiredness / lethargy in last 2 weeks	4.7	7.6	17.7	-4.2	-1.1	-2.5	0.7	-2.2	-4.2	-0.1	-3.6
Falls in the last year	1.5	2.1	5.9	-1.4	-0.1	-1.6	-1.7	1.2	-1.1	-2.4	-0.4
Hair/balding pattern: Pattern 3	2.7	4.0	9.3	-1.3	-3.1	-1.5	1.2	-2.8	-0.6	3.0	0.0
Number of live births	2.0	2.8	6.5	1.5	0.9	0.5	-1.6	1.4	1.8	-2.2	2.5
Forced expiratory volume in 1-second (FEV1)	2.0	6.9	14.7	2.8	3.7	3.8	1.4	3.0	2.1	-1.7	-0.9
Pulse rate	0.3	0.6	3.6	0.3	0.6	0.1	-0.3	1.9	-0.1	0.0	-0.7
Happiness	1.9	2.3	5.0	-2.1	-0.6	-1.9	-1.5	-0.9	-2.2	0.3	-1.4
Noisy workplace	2.1	2.5	6.4	1.6	0.3	0.5	-1.9	1.3	1.6	-2.5	1.9
Qualifications: A levels/AS levels or equivalent	1.3	3.0	11.0	-0.8	-0.3	0.2	1.2	-1.5	-1.6	2.5	-3.3
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.6	0.1	-0.7	1.0	1.6	-1.0	-0.1	0.1	-0.5
Mouth/teeth dental problems: Dentures	0.8	1.3	4.3	0.6	2.1	0.5	-1.5	0.9	0.4	-1.5	0.2
Asthma	1.3	2.6	5.0	-2.1	-1.2	-1.3	-0.8	-1.8	-2.2	-1.4	-1.5
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.5	7.5	-0.2	-0.4	0.5	2.1	-1.2	-1.3	2.1	-2.7
Medication: Cholesterol lowering	0.8	1.2	2.8	-1.6	-0.7	-1.7	-1.5	-0.4	-1.0	-0.7	0.2
Depression (self-reported)	1.3	1.5	2.6	-1.6	0.4	-0.6	-1.2	1.3	-1.6	-1.2	-1.5
Medication: Lansoprazole	0.5	0.6	1.3	-0.9	-0.4	-0.7	-0.4	-1.1	-0.8	0.8	-0.8
Prospective memory result	1.5	1.8	9.2	0.4	-1.5	-0.6	0.1	0.4	1.4	-0.3	3.0
Lung cancer (father)	3.5	4.1	9.1	1.5	3.0	2.1	-1.4	1.8	1.5	-2.8	1.1
Illnesses of mother	1.1	1.3	7.3	0.5	0.4	0.5	0.2	1.3	0.7	2.7	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	3.0	9.5	21.7	3.7	4.0	4.7	1.6	3.4	2.8	-1.4	-0.4
Pulse wave Arterial Stiffness index	1.0	1.1	2.6	-1.3	-0.6	-1.6	-0.6	-0.3	-1.3	-1.2	-0.8
Impedance of arm (left)	0.2	0.8	2.5	-1.0	0.0	-0.8	1.1	-1.6	-0.5	0.8	-0.2
Arm fat mass (right)	1.3	5.2	13.9	-0.5	-3.7	-3.4	-2.3	-0.5	0.7	0.9	3.0
Trunk predicted mass	2.1	11.8	32.9	3.4	3.5	2.6	-2.4	5.7	3.0	-3.5	2.0
Standing height	2.2	22.1	56.6	3.6	7.5	4.7	-0.8	6.6	2.7	-5.8	0.2
Length of working week for main job	1.2	1.3	3.5	1.4	0.8	1.1	-1.2	1.9	1.0	-0.6	0.5
Exposure to tobacco smoke at home	0.8	0.9	3.0	0.3	-1.7	-0.4	0.6	-1.2	0.5	0.2	1.3
Breastfed as a baby	2.8	3.5	6.4	2.0	2.5	2.0	0.7	2.5	1.2	-2.2	0.6
Tense / ‘highly strung’	0.8	1.3	5.9	-0.7	-0.4	-0.0	1.2	-1.5	-0.6	-2.4	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.2	10.4	-3.2	-0.3	-2.2	-0.4	-0.2	-2.7	-1.2	-1.2
Hair/balding pattern: Pattern 4	2.4	5.8	16.2	-2.7	-2.6	-4.0	-0.7	-2.3	-2.9	0.7	-1.4
Birth weight of first child	1.1	1.9	4.2	1.3	1.6	2.1	0.8	0.9	0.5	1.5	-1.8
Peak expiratory flow (PEF)	0.8	1.9	4.3	0.8	2.1	1.4	1.4	1.6	0.4	-1.5	-1.2
Pulse wave reflection index	0.6	0.8	2.0	-0.8	-0.9	-1.4	-1.1	-1.0	-0.6	-0.1	-0.0
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.3	-0.1	0.3	-0.6	-1.4	1.5	-0.5	-1.0	-0.8
Loud music exposure frequency	1.0	1.1	2.4	1.2	-1.4	0.3	-0.2	-0.7	1.4	0.0	1.5
Qualifications: O levels/GCSEs or equivalent	1.7	2.7	5.9	-1.5	-0.0	-0.3	1.8	-1.4	-1.7	2.2	-2.4
Mouth/teeth dental problems: Bleeding gums	5.0	6.5	21.4	1.9	-0.7	2.2	2.7	-2.1	3.0	0.6	4.6
Blood clot in the leg (DVT)	2.0	2.6	8.8	1.8	3.0	1.1	-0.4	2.1	1.3	-1.0	0.1
Medication: Paracetamol	0.6	0.9	4.4	-0.5	-0.7	-0.7	0.6	-0.2	-1.2	0.2	-2.1
Headache pain in last month	1.4	2.4	8.6	-0.6	0.4	1.0	2.4	-1.2	-1.3	0.5	-2.9
Medication for cholesterol, blood pressure or diabetes	2.3	3.8	6.8	2.5	2.2	2.6	1.9	1.6	1.8	1.9	-0.5
Glaucoma (self-reported)	1.7	2.0	6.0	1.1	2.5	1.8	0.2	1.5	0.1	-1.0	-1.6
Gout (self-reported)	0.4	0.6	1.9	-0.2	-0.5	-0.7	-1.4	-0.2	-0.2	-1.1	0.7
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	7.9	-1.4	-1.8	-2.8	-1.7	-0.6	-1.1	-0.3	0.8
Medication: Amlodipine	2.9	4.0	8.3	-2.6	-2.3	-2.9	-2.1	-1.8	-1.5	-1.2	0.8
Medication: Ventolin 100micrograms inhaler	1.3	1.6	3.4	-1.9	0.4	-1.2	-1.4	-0.0	-1.8	-1.3	-1.0
Birth weight	1.5	3.3	7.0	1.4	2.6	1.9	-1.8	2.0	0.6	-2.5	-0.7
Chronic bronchitis/emphysema (mother)	1.3	1.5	3.4	0.5	1.4	-0.2	-1.4	1.3	0.7	-1.8	1.5
High blood pressure (siblings)	1.3	1.9	8.0	-0.3	-1.2	-0.5	0.3	-1.3	0.3	-2.8	1.9
Forced vital capacity (FVC), Best measure	4.5	16.6	31.1	4.5	5.6	5.6	0.7	5.1	3.6	-3.2	0.6
Body fat percentage	1.8	7.2	19.0	-1.7	-4.4	-4.3	-1.8	-2.5	-0.4	1.4	2.4
Leg fat percentage (right)	1.7	6.2	17.0	-1.6	-4.1	-3.8	-1.7	-2.9	-0.6	1.1	1.8
Arm fat-free mass (right)	1.1	5.8	17.5	2.1	2.2	1.3	-2.2	4.2	1.8	-2.8	1.4
Exposure to tobacco smoke outside home	1.5	2.0	5.0	-1.0	-1.7	-0.1	2.2	-2.2	-0.7	1.5	0.1
Comparative body size at age 10	1.9	5.3	14.4	0.7	-3.8	-2.8	-1.8	0.4	1.6	1.5	3.3
Number of full brothers	1.1	1.3	3.3	0.8	-0.2	0.0	-1.5	0.8	0.9	-1.8	1.8
Worry too long after embarrassment	0.3	0.4	1.3	-1.1	-0.1	-0.4	0.2	-0.3	-1.0	-0.8	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.5	-1.1	0.7	-0.6	-1.2	1.2	-0.8	-1.0	-0.8
Wheeze or whistling in the chest in last year	1.3	2.3	7.9	-0.7	0.8	-1.2	-2.8	0.2	-0.7	-2.6	0.9
Number of children fathered	3.0	3.4	7.7	2.7	0.6	1.5	-0.7	1.2	2.7	-0.5	2.8
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	3.9	-0.1	-0.1	-0.7	-2.0	0.8	0.2	-0.8	0.9
Age at first live birth	2.9	5.1	17.8	-2.5	-1.0	-2.1	0.3	-0.6	-2.8	1.8	-4.2
Pulse wave peak to peak time	1.1	1.3	3.4	1.4	1.2	1.9	0.5	0.6	1.4	0.6	0.8
Health satisfaction	0.5	0.6	2.5	-0.6	-0.1	-0.6	-1.0	-0.7	-0.7	-1.6	0.0
Shortness of breath walking on level ground	2.7	3.2	7.9	-2.8	-1.1	-2.4	0.2	-1.1	-2.4	0.4	-1.8
Qualifications: College or University degree	0.6	1.8	6.2	-0.8	-1.0	-1.2	-0.6	0.5	-1.3	1.6	-2.5
Eye problems/disorders: None of the above	0.6	0.7	3.0	-0.2	0.3	0.7	1.7	-0.8	-0.5	-0.1	-0.8
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.3	-0.6	0.3	-0.6	-0.6	0.1	0.1	0.1	1.2
Emphysema/chronic bronchitis	0.7	0.7	4.4	-0.0	0.2	0.3	-0.2	0.4	0.1	-2.1	1.1
Medication for pain relief, constipation, heartburn	0.8	1.3	3.4	0.4	1.8	0.4	-1.0	1.7	0.9	-1.0	1.1
Neck or shoulder pain in last month	1.2	1.7	4.6	-1.2	-0.3	-1.3	-0.3	0.1	-2.0	-1.1	-2.1
Medication: Blood pressure	3.9	6.8	11.5	-2.9	-3.4	-3.3	-2.0	-2.6	-2.3	-2.8	0.5
Angina (self-reported)	1.2	1.6	3.6	-1.4	-1.4	-1.5	-0.2	-1.9	-1.4	0.2	-1.0
Migraine (self-reported)	1.8	2.2	8.1	0.1	1.8	1.2	1.0	1.4	-1.0	-0.8	-2.8
Medication: Ibuprofen	1.9	2.3	5.5	-0.2	-1.0	0.4	1.7	-1.4	-1.2	2.3	-2.3
Medication: Allopurinol	0.8	1.1	4.4	-0.9	-2.1	-1.6	-0.2	-0.5	-0.7	-0.4	0.2
Medication: Omeprazole	0.4	0.4	2.1	0.0	-0.6	-0.7	-1.4	0.5	0.1	0.0	-0.4
Medication: Seretide 50 evohaler	0.8	1.0	3.8	0.1	0.3	-0.0	-1.5	0.8	0.3	-1.9	0.9
Mean time to correctly identify matches	11.2	21.4	43.5	5.1	4.0	3.9	-2.0	4.5	6.0	-3.3	6.6
Heart disease (mother)	0.8	1.0	3.6	0.2	0.5	0.6	-0.1	-0.3	0.7	-1.9	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	4.3	-1.6	-1.0	-2.1	-0.8	-1.1	-1.5	-0.3	-0.9
Whole body fat mass	1.0	4.1	10.0	-0.5	-3.2	-3.2	-2.0	-0.7	0.6	0.2	2.8
Leg fat mass (right)	1.0	4.0	10.1	-0.6	-3.2	-3.1	-2.4	-0.7	0.4	0.1	2.4
Arm predicted mass (right)	1.2	6.2	18.1	2.3	2.3	1.4	-2.3	4.2	1.9	-2.7	1.6
Pulse rate, automated reading	0.8	2.5	8.7	-0.2	1.5	-0.7	-2.4	3.0	-0.6	-0.4	-1.6
Alcohol intake frequency.	0.3	0.6	2.9	1.2	-0.3	-0.1	0.2	0.1	0.8	1.7	0.1
Comparative height size at age 10	2.9	15.8	35.0	3.5	5.2	3.4	-1.0	5.9	2.8	-5.3	1.7
Number of full sisters	0.7	0.8	2.4	1.3	-0.2	0.2	-0.2	0.3	1.3	-0.8	1.6
Suffer from ‘nerves’	5.0	7.9	19.0	-4.0	1.5	-0.4	1.0	-1.7	-4.4	-2.1	-4.2
Overall health rating	4.1	8.8	15.0	-3.7	-1.1	-3.9	-3.3	-0.2	-3.6	-3.5	-1.9
Chest pain or discomfort	1.6	2.3	11.7	-0.3	2.1	0.6	-0.7	0.5	-0.9	-3.4	-0.6
Had major operations	2.5	2.9	6.2	-2.3	-0.9	-0.8	1.9	-1.1	-2.5	0.9	-2.2
Age at last live birth	0.8	1.1	4.6	-0.8	0.8	-0.8	-0.3	0.6	-1.2	-0.7	-2.1
Family relationship satisfaction	0.6	0.8	2.2	0.1	1.5	0.8	-0.4	0.7	-0.1	-1.5	0.7
Leg pain on walking	1.8	2.2	8.6	-1.5	0.6	-1.4	-1.4	0.1	-1.4	-2.9	-1.0
Qualifications: NVQ or HND or HNC or equivalent	2.5	3.0	6.9	2.6	1.4	1.9	-0.4	1.4	2.6	0.2	1.7
Commuting to job workplace: Car/motor vehicle	3.9	4.5	9.1	2.9	2.0	3.0	1.2	1.9	2.7	0.3	1.4
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.7	0.2	-0.4	-0.8	-0.4	-0.2	0.2	0.9	0.6
Medication: Aspirin	0.7	0.9	2.7	-1.0	-0.8	-1.4	-1.6	-0.4	-0.7	-0.3	0.5
Supplements: Vitamin C	2.0	2.3	4.8	2.2	0.8	2.2	1.6	1.2	1.9	0.4	0.8
Knee pain experienced in last month	1.4	2.2	5.2	1.2	2.2	2.3	1.0	1.4	1.0	-1.4	-0.4
Hypertension (Self-reported)	5.1	14.3	33.8	-4.0	-5.6	-4.2	-0.3	-5.8	-2.9	-2.4	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	6.9	1.4	1.8	2.6	1.7	0.1	0.7	-0.6	-0.0
Illnesses of father: Heart disease	1.0	1.3	2.7	-1.6	-1.0	-1.2	-1.1	-0.7	-1.6	-1.0	-0.4
Illnesses of siblings: Diabetes	0.9	1.1	2.3	0.3	-1.5	-0.9	-0.2	-0.8	0.8	1.5	1.4
Smoking status: Previous	1.0	1.6	3.9	0.9	-0.2	-0.2	-2.0	1.6	1.3	-0.9	1.6
Forced expiratory volume in 1-second (FEV1), predicted	2.9	6.1	13.4	2.7	3.3	3.0	-0.4	3.7	2.1	-1.7	0.1
Whole body fat-free mass	1.5	8.5	24.9	2.8	2.2	1.6	-2.6	5.0	2.8	-2.8	2.3
Leg fat-free mass (right)	1.0	5.5	15.3	2.1	0.2	-0.0	-2.8	3.9	2.5	-1.7	2.8
Arm fat percentage (left)	2.5	9.9	29.8	-1.6	-5.5	-4.8	-2.2	-2.3	0.0	2.3	3.0
Average weekly red wine intake	0.2	0.3	1.4	0.4	-0.6	-0.3	-1.2	-0.2	0.1	0.7	-0.2
Handedness (chirality/laterality): Left-handed	0.4	0.5	2.2	-0.9	-0.1	-0.2	0.9	-0.6	-0.3	1.5	-0.1
Mood swings	2.9	5.3	12.3	-2.9	-1.0	-1.2	0.6	-3.5	-3.0	-2.7	-1.7
Loneliness, isolation	3.6	5.0	12.6	-3.3	0.9	-1.0	-0.3	-1.4	-3.5	-1.7	-3.2
Long-standing illness, disability or infirmity	1.7	2.6	10.2	-0.7	0.7	-1.0	-2.0	2.1	-0.5	-3.2	0.2
Ever had bowel cancer screening	0.5	0.6	2.8	0.8	0.6	0.5	0.2	0.3	0.7	1.7	0.4
Diabetes diagnosed by doctor	0.9	1.5	8.6	-0.1	-0.2	-1.2	-2.9	0.3	0.1	1.1	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.7	0.7	1.3	0.9	0.4	-0.3	0.6	0.3	0.3
Friendships satisfaction	1.8	2.3	5.0	-1.4	1.6	-1.2	-2.2	1.1	-1.5	-1.5	-1.3
Qualifications: nursing, teaching	1.6	2.5	4.2	-1.9	-1.9	-2.0	-1.7	-0.4	-1.6	1.4	-1.0
Commuting to job workplace: Walk	2.1	2.2	4.4	-1.9	-0.9	-1.5	-0.3	-1.5	-2.1	-0.4	-2.0
Eye problems/disorders: Cataract	1.0	1.2	5.2	-0.3	-0.3	-1.6	-2.3	1.0	0.0	0.3	0.5
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.5	1.0	-0.9	0.5	1.0	0.4	1.5	0.1	1.6
Medication for cholesterol	1.4	2.1	4.9	1.3	2.2	2.0	0.8	1.6	0.5	0.6	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	7.5	1.4	-0.9	0.8	0.4	0.4	2.3	0.6	2.7
Back pain experienced in last month	3.5	5.0	15.4	-2.5	-1.3	-1.7	0.9	-1.7	-3.0	0.9	-3.9
Mineral and other dietary supplements	0.3	0.4	1.5	0.0	1.2	0.3	-0.5	0.2	0.1	-1.0	0.0
Breast cancer (self-reported)	0.1	0.1	0.3	-0.2	0.5	-0.2	-0.2	0.3	0.4	-0.1	0.4
Asthma (self-reported)	1.2	2.3	4.6	-2.0	-1.0	-1.1	-0.8	-1.6	-2.1	-1.6	-1.4
Osteoporosis (self-reported)	4.6	5.6	12.3	-3.2	-1.3	-1.9	0.2	-1.8	-3.3	1.6	-3.5
Osteoarthritis (self-reported)	1.3	1.6	3.0	-1.4	-0.8	-1.5	-1.6	0.0	-1.7	-1.2	-1.2
Medication: Aspirin	0.7	0.9	3.4	-0.7	-0.6	-1.3	-1.9	-0.2	-0.3	-0.4	0.9
Medication: Gliclazide	0.9	1.0	2.8	0.3	0.0	-0.9	-1.7	0.9	0.8	0.6	1.5
Illnesses of father: None of the above (group 1)	3.4	4.2	7.7	2.7	2.0	2.8	2.2	1.3	2.5	1.2	1.0
Smoking status: Current	1.6	2.5	8.5	-0.2	2.4	-0.1	-2.0	1.0	-0.5	-2.9	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.0	4.2	8.7	2.7	0.7	3.0	2.7	0.4	2.6	0.9	1.5
Whole body water mass	1.5	8.3	24.3	2.8	2.2	1.6	-2.6	4.9	2.7	-2.7	2.2
Leg predicted mass (right)	1.1	5.6	15.2	2.2	0.3	0.1	-2.7	3.9	2.5	-1.6	2.9
Arm fat mass (left)	1.2	4.9	12.0	-0.5	-3.5	-3.4	-2.5	-0.3	0.7	0.9	2.9
Number of self-reported non-cancer illnesses	4.6	8.0	18.1	-4.2	-1.5	-3.4	-1.2	-1.7	-4.2	-1.3	-2.9
Average weekly champagne plus white wine intake	1.8	2.5	6.7	1.7	1.9	2.6	1.9	-0.4	1.5	0.5	0.8
Miserableness	6.0	10.3	22.2	-4.0	-1.8	-2.6	-0.2	-4.7	-4.5	-2.3	-3.0
Guilty feelings	2.0	2.9	6.1	-2.1	-1.0	-2.1	-1.5	-0.9	-2.0	-2.5	-0.8
Wears glasses or contact lenses	0.7	0.8	2.6	0.2	0.1	-0.5	-1.5	0.6	0.3	-1.6	1.1
Ever taken oral contraceptive pill	1.3	1.5	7.7	-0.4	0.5	0.4	0.7	0.1	-1.1	1.4	-2.8
Hearing aid user	0.7	0.8	1.9	0.2	-1.4	-0.6	-0.6	-0.5	0.6	1.3	1.3
Mother’s age at death	0.9	1.1	3.3	-0.2	-0.8	0.9	1.8	-1.3	-0.5	0.9	-1.1
Financial situation satisfaction	0.5	0.6	1.5	-0.7	1.2	0.6	0.2	0.8	-0.7	-0.8	-0.7
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.0	0.2	1.0	0.5	0.2	-0.7	0.3	-0.8	0.6
Commuting to job workplace: Public transport	1.3	1.6	3.3	-1.8	-1.2	-1.6	-0.0	-0.7	-1.7	-0.8	-1.1
Eye problems/disorders: Glaucoma	2.5	2.9	12.2	0.4	3.5	1.6	-0.0	2.1	-0.4	-0.8	-1.9
Medication: Blood pressure	2.5	4.8	16.6	-1.5	-3.5	-1.6	1.3	-4.1	-0.6	0.2	1.8
Pain type(s) experienced in last month: Hip pain	1.7	2.1	3.8	-1.3	-0.7	-1.9	-1.9	0.0	-1.6	-1.7	-1.5
Supplements: Fish oil (including cod liver oil)	0.8	1.1	2.1	1.1	-1.4	0.2	0.2	0.8	1.2	1.2	1.3
High cholesterol (Self-reported)	1.2	2.1	5.8	-2.4	-0.6	-2.0	-0.9	-1.4	-1.8	-0.7	0.2
Medication: Bendroflumethiazide	2.4	3.6	12.8	-1.4	-2.7	-1.5	0.6	-3.6	-1.1	-1.6	0.8
Medication: Paracetamol	0.5	0.8	3.1	-0.2	-0.8	-0.7	0.7	0.2	-0.8	1.2	-1.7
Medication: Lisinopril	2.7	3.5	10.4	-2.3	-2.1	-2.1	0.2	-3.2	-1.8	-0.2	-0.3
Medication: Atorvastatin	1.1	1.4	7.2	-0.5	-0.7	-1.2	-2.7	0.2	0.2	-0.8	1.1
Illnesses of father: High blood pressure	0.8	1.0	3.9	-0.2	0.2	0.4	1.2	-1.0	0.2	-2.0	1.0
Alcohol drinker status: Never	0.5	0.6	1.5	0.1	-1.0	-0.7	0.7	-1.0	-0.0	1.2	0.1
Ever smoked	1.0	1.8	6.8	0.7	1.2	-0.1	-1.4	1.7	0.4	-2.6	0.9
Basal metabolic rate	1.1	6.2	17.9	2.4	1.3	0.8	-2.6	4.2	2.5	-2.3	2.4
Leg fat percentage (left)	1.7	6.2	17.6	-1.5	-4.2	-3.8	-1.6	-2.6	-0.3	1.2	2.2
Arm fat-free mass (left)	1.1	5.3	16.1	1.9	2.0	1.2	-2.3	4.0	1.8	-2.6	1.4
Number of operations (self-reported)	0.7	1.1	3.8	-0.0	0.8	0.6	1.4	0.1	-0.1	2.0	-1.2
Average weekly beer plus cider intake	3.0	4.3	10.0	1.1	2.6	1.4	-1.1	2.7	1.6	-3.2	1.8
Irritability	0.5	0.9	2.0	-1.1	0.1	-0.3	0.2	-0.8	-1.3	-1.2	-1.4
Risk taking	1.0	1.5	6.9	0.6	1.1	0.6	-1.1	2.6	0.9	-0.9	0.6
Ever had prostate specific antigen (PSA) test	1.9	2.2	3.6	-1.9	-1.0	-1.7	0.4	-0.7	-1.9	1.7	-1.8
Fractured/broken bones in last 5 years	1.5	1.9	4.4	-2.1	-0.7	-0.3	1.1	-1.2	-1.9	0.8	-1.8
Age started oral contraceptive pill	1.0	1.2	5.4	-0.7	-0.3	0.3	2.3	-1.6	-0.6	0.6	-0.4
Diastolic blood pressure, automated reading	1.9	5.8	13.3	-2.4	-2.6	-3.1	-1.2	-2.3	-2.0	-3.6	0.6
Ever depressed for a whole week	0.2	0.2	1.1	-0.1	0.6	-0.1	-0.4	1.1	0.2	-0.4	0.2
Unable to work because of sickness or disability	1.5	1.9	7.8	-0.7	0.3	-1.1	-1.6	1.6	-0.7	-2.8	0.2
Commuting to job workplace: Cycle	0.4	0.5	1.6	-0.2	-1.3	-1.0	-0.9	-0.5	-0.2	0.4	0.1
Myopia	2.4	3.5	11.3	1.1	3.4	2.0	0.8	2.6	1.0	-1.7	0.5
Vascular/heart problems diagnosed by doctor	5.5	15.0	32.3	4.3	5.4	4.6	0.5	5.7	3.4	2.5	-0.6
Cholesterol lowering medication	1.7	2.6	6.1	-2.0	-1.4	-2.3	-0.4	-2.5	-1.5	0.7	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.6	0.2	-0.5	-0.5	-0.8	0.3	0.2	0.3	-0.4
Pain experienced in last month	2.1	3.4	10.3	1.7	0.5	0.4	-2.2	1.8	2.3	-0.9	3.2
Supplements: Calcium	1.3	1.5	4.5	-1.4	0.0	-0.8	0.2	0.3	-1.5	1.4	-2.1
Basal cell carcinoma (self-reported)	1.0	1.2	2.6	-1.5	-1.6	-1.6	0.2	-1.0	-0.9	0.7	0.1
Heart attack/myocardial infarction (self-reported)	1.5	1.9	4.3	-1.3	0.2	-2.0	-2.1	0.5	-1.2	-1.9	-0.6
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	7.7	1.9	2.8	1.2	-0.2	2.3	1.6	-1.1	0.5
Heart disease (siblings)	1.1	1.3	2.4	0.8	1.5	0.3	-0.8	1.3	1.1	-1.4	1.4
Alcohol drinker status: Previous	2.3	2.6	7.2	-2.1	-0.3	-2.7	-2.4	-0.4	-1.6	0.7	-0.9
Pack years of smoking	1.5	2.2	6.8	-0.3	0.6	-0.9	-2.6	2.0	0.1	-1.8	1.5
Impedance of whole body	0.5	2.3	6.3	-1.2	1.3	0.1	2.2	-2.5	-1.3	-0.0	-1.6
Leg fat mass (left)	1.0	4.1	9.2	-0.3	-3.0	-3.0	-2.4	-0.3	0.7	0.1	2.8
Arm predicted mass (left)	1.0	4.9	14.1	1.9	2.1	1.2	-2.2	3.8	1.7	-2.5	1.3