Best TWAS P=1.09e-19 · Best GWAS P=5.17e-21 conditioned to 1.09e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CEP120 | 0.12 | 0.08 | lasso | 3 | 0.05 | 5.5e-05 | -6.43 | -6.6 | 4.8e-11 | -0.02 | 0.87 | 0.00 | FALSE |
| 2 | GTEx | Artery Aorta | KRT8P33 | 0.10 | 0.04 | lasso | 6 | 0.05 | 9.1e-04 | 3.44 | -5.6 | 1.8e-08 | 0.00 | 0.24 | 0.04 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | PPIC | 0.02 | 0.12 | lasso | 1 | 0.09 | 9.5e-04 | -5.31 | 5.3 | 1.1e-07 | 0.29 | 0.04 | 0.05 | FALSE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | KRT8P33 | 0.16 | -0.01 | lasso | 8 | 0.01 | 2.1e-01 | -6.56 | -5.8 | 5.0e-09 | -0.04 | 0.12 | 0.06 | FALSE |
| 5 | GTEx | Ovary | SNX24 | 0.22 | 0.02 | enet | 16 | 0.01 | 1.8e-01 | -8.74 | -9.1 | 1.1e-19 | -0.54 | 0.11 | 0.39 | TRUE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | PPIC | 0.08 | 0.03 | bslmm | 433 | 0.04 | 2.3e-06 | 0.91 | 5.3 | 1.1e-07 | 0.07 | 0.80 | 0.01 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CSNK1G3 | 0.06 | 0.04 | enet | 10 | 0.05 | 2.3e-06 | -6.18 | -6.8 | 8.4e-12 | 0.04 | 0.02 | 0.98 | TRUE |