[Hub]/) : Traits : Systolic Blood Pressure : ← →

chr10:68,861,272-70,532,990

Best TWAS P=6.89e-13 · Best GWAS P=3.03e-12 conditioned to 0.528

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex HERC4 0.05 0.03 bslmm 408 0.03 4.2e-05 5.1 -5.5 3.5e-08 -0.41 0.57 0.02 FALSE
2 GTEx Esophagus Mucosa SIRT1 0.06 0.02 enet 9 0.02 2.1e-02 2.3 5.2 2.2e-07 0.83 0.05 0.80 FALSE
3 GTEx Muscle Skeletal DNAJC12 0.05 0.04 enet 9 0.02 2.7e-03 4.8 6.7 2.1e-11 0.74 0.17 0.78 FALSE
4 GTEx Testis DNAJC12 0.22 0.15 lasso 6 0.12 5.2e-06 5.5 5.8 6.1e-09 0.51 0.47 0.26 FALSE
5 GTEx Testis HERC4 0.12 0.08 lasso 2 0.05 2.0e-03 5.1 5.2 2.3e-07 0.46 0.17 0.20 FALSE
6 GTEx Whole Blood SIRT1 0.07 0.07 enet 7 0.06 1.3e-06 6.6 6.7 1.7e-11 0.97 0.07 0.93 FALSE
7 YFS Blood HERC4 0.03 0.02 bslmm 402 0.03 6.2e-10 5.1 6.0 2.7e-09 0.71 0.29 0.71 FALSE
8 YFS Blood SIRT1 0.10 0.20 lasso 5 0.20 1.4e-63 6.8 6.8 8.3e-12 0.96 0.06 0.94 FALSE
9 The Cancer Genome Atlas Bladder Urothelial Carcinoma SIRT1 0.02 0.02 blup 42 0.01 6.3e-02 6.8 6.7 2.0e-11 0.95 0.02 0.75 FALSE
10 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SIRT1 0.03 0.02 blup 42 0.03 3.2e-04 6.9 5.9 3.6e-09 0.88 0.02 0.91 FALSE
11 The Cancer Genome Atlas Lung Adenocarcinoma HERC4 0.03 0.02 blup 77 0.01 6.7e-03 6.9 6.5 6.8e-11 0.98 0.02 0.94 FALSE
12 The Cancer Genome Atlas Prostate Adenocarcinoma SIRT1 0.05 0.06 enet 8 0.06 1.7e-06 6.6 7.2 6.9e-13 0.94 0.03 0.97 TRUE
13 The Cancer Genome Atlas Thyroid Carcinoma HERC4 0.04 0.02 lasso 4 0.03 3.1e-04 7.0 5.5 5.1e-08 0.90 0.03 0.95 FALSE
14 The Cancer Genome Atlas Thyroid Carcinoma SIRT1 0.04 0.05 lasso 1 0.04 2.0e-04 6.9 6.8 7.3e-12 0.94 0.02 0.98 FALSE