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chr10:74,206,576-77,160,682

Best TWAS P=1.8e-25 · Best GWAS P=8.99e-19 conditioned to 0.0558

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ADK	0.03	0.03	lasso	3	0.04	2.6e-05	5.6	6.2	4.0e-10	0.06	0.79	0.01	FALSE
2	CommonMind	Brain Pre-frontal Cortex	BMS1P4	0.17	0.20	lasso	1	0.19	1.2e-22	6.7	-6.7	2.5e-11	-0.44	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	DNAJC9	0.01	0.02	enet	6	0.02	2.5e-03	4.5	-6.1	1.1e-09	-0.44	0.25	0.10	FALSE
4	CommonMind	Brain Pre-frontal Cortex	FAM149B1	0.03	0.03	blup	222	0.03	4.0e-05	4.9	5.2	2.5e-07	0.46	0.93	0.03	FALSE
5	CommonMind	Brain Pre-frontal Cortex	VCL	0.07	0.05	lasso	4	0.06	6.0e-08	-7.2	-7.5	8.0e-14	-0.10	1.00	0.00	FALSE
6	GTEx	Adipose Subcutaneous	SEC24C	0.04	0.02	lasso	2	0.00	1.3e-01	4.8	5.3	1.2e-07	0.32	0.26	0.07	FALSE
7	GTEx	Adipose Subcutaneous	FUT11	0.08	0.09	enet	13	0.11	5.0e-09	6.9	-8.2	2.4e-16	-0.68	0.31	0.68	FALSE
8	GTEx	Adipose Visceral Omentum	FUT11	0.11	0.06	lasso	6	0.11	1.9e-06	8.2	-10.4	1.8e-25	-0.72	0.09	0.71	TRUE
9	GTEx	Adrenal Gland	AGAP5	0.22	0.05	lasso	4	0.04	1.8e-02	6.2	5.9	3.3e-09	0.32	0.10	0.06	FALSE
10	GTEx	Artery Aorta	TTC18	0.15	0.12	enet	12	0.14	5.0e-08	4.7	-6.0	1.7e-09	-0.55	0.80	0.18	FALSE
11	GTEx	Artery Aorta	FUT11	0.07	0.04	enet	16	0.04	2.9e-03	7.0	-6.2	4.6e-10	-0.28	0.41	0.10	FALSE
12	GTEx	Brain Cerebellar Hemisphere	TTC18	0.13	0.10	enet	24	0.13	3.3e-04	4.5	-5.4	5.5e-08	-0.43	0.48	0.18	FALSE
13	GTEx	Brain Cerebellar Hemisphere	RP11-464F9.22	0.22	0.04	lasso	4	0.07	7.3e-03	3.8	-5.6	2.3e-08	-0.17	0.06	0.05	FALSE
14	GTEx	Breast Mammary Tissue	FUT11	0.07	0.08	lasso	5	0.03	1.1e-02	4.8	-5.3	8.9e-08	-0.36	0.14	0.18	FALSE
15	GTEx	Cells Transformed fibroblasts	ECD	0.15	0.03	enet	18	0.07	4.5e-06	4.5	-5.2	2.0e-07	-0.43	0.70	0.08	FALSE
16	GTEx	Cells Transformed fibroblasts	FAM149B1	0.22	0.08	lasso	4	0.05	7.6e-05	5.0	5.4	7.4e-08	0.43	0.74	0.07	FALSE
17	GTEx	Cells Transformed fibroblasts	FUT11	0.13	0.08	lasso	4	0.08	1.5e-06	6.9	-8.0	9.7e-16	-0.59	0.76	0.22	FALSE
18	GTEx	Cells Transformed fibroblasts	DNAJC9-AS1	0.12	0.00	enet	10	0.05	7.5e-05	3.0	5.6	2.1e-08	0.50	0.07	0.32	FALSE
19	GTEx	Colon Sigmoid	TTC18	0.09	0.06	lasso	14	0.07	1.6e-03	5.0	-7.0	2.1e-12	-0.66	0.20	0.66	FALSE
20	GTEx	Colon Transverse	ADK	0.25	0.14	lasso	9	0.12	1.6e-06	6.3	6.9	5.1e-12	0.08	0.99	0.00	FALSE
21	GTEx	Esophagus Mucosa	TTC18	0.15	0.13	enet	10	0.14	2.1e-09	4.5	-6.3	3.5e-10	-0.56	0.99	0.01	FALSE
22	GTEx	Esophagus Mucosa	SEC24C	0.11	0.08	lasso	4	0.10	6.7e-07	6.7	-7.3	2.6e-13	-0.50	0.92	0.08	FALSE
23	GTEx	Esophagus Mucosa	FUT11	0.15	0.21	lasso	5	0.21	2.5e-14	6.7	-7.2	8.1e-13	-0.51	1.00	0.00	FALSE
24	GTEx	Heart Atrial Appendage	MYOZ1	0.43	0.25	lasso	11	0.38	5.4e-18	8.3	9.6	9.3e-22	0.84	0.04	0.96	FALSE
25	GTEx	Heart Atrial Appendage	FUT11	0.13	0.02	enet	22	0.10	4.7e-05	7.9	-8.9	3.6e-19	-0.71	0.12	0.73	FALSE
26	GTEx	Heart Left Ventricle	DUSP8P5	0.13	0.04	lasso	12	0.03	5.8e-03	6.7	8.0	1.4e-15	0.55	0.07	0.69	FALSE
27	GTEx	Lung	ADK	0.15	0.17	lasso	5	0.17	4.8e-13	5.5	-5.2	2.5e-07	-0.02	1.00	0.00	FALSE
28	GTEx	Muscle Skeletal	FUT11	0.10	0.10	enet	16	0.11	8.5e-11	5.7	-6.6	4.0e-11	-0.45	1.00	0.00	FALSE
29	GTEx	Nerve Tibial	AGAP5	0.08	0.01	lasso	8	0.02	2.0e-02	6.9	7.3	3.8e-13	0.40	0.53	0.11	FALSE
30	GTEx	Nerve Tibial	AP3M1	0.06	0.02	lasso	2	0.02	2.6e-02	5.9	6.1	1.2e-09	0.04	0.20	0.04	FALSE
31	GTEx	Nerve Tibial	FUT11	0.19	0.16	enet	28	0.18	1.0e-12	7.0	-7.4	1.4e-13	-0.61	0.96	0.04	FALSE
32	GTEx	Pancreas	AGAP5	0.13	0.05	lasso	5	0.06	1.8e-03	5.5	9.0	2.8e-19	0.28	0.13	0.13	FALSE
33	GTEx	Pituitary	RP11-178G16.5	0.13	0.10	lasso	2	0.02	1.1e-01	5.9	-6.0	1.9e-09	-0.05	0.08	0.13	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	AGAP5	0.11	0.07	lasso	5	0.07	1.8e-04	6.7	7.4	1.1e-13	0.49	0.43	0.11	FALSE
35	GTEx	Skin Sun Exposed Lower leg	FUT11	0.06	0.03	lasso	4	0.04	1.7e-04	6.7	-8.0	1.8e-15	-0.69	0.16	0.71	FALSE
36	GTEx	Skin Sun Exposed Lower leg	DNAJC9	0.05	0.00	enet	9	0.01	2.1e-02	4.6	-6.0	1.7e-09	-0.47	0.45	0.05	FALSE
37	GTEx	Thyroid	ADK	0.10	0.05	lasso	3	0.05	1.6e-04	5.5	-5.5	4.8e-08	-0.03	0.66	0.01	FALSE
38	GTEx	Thyroid	FUT11	0.11	0.02	lasso	6	0.04	3.8e-04	5.3	-6.4	1.5e-10	-0.54	0.50	0.33	FALSE
39	GTEx	Whole Blood	FUT11	0.05	0.01	lasso	5	0.01	6.3e-02	5.8	-7.8	7.7e-15	-0.61	0.14	0.46	FALSE
40	ROSMAP	Brain Pre-frontal Cortex	MYOZ1	0.04	0.01	blup	235	0.02	2.6e-03	8.3	-7.6	2.5e-14	-0.70	0.07	0.81	FALSE
41	ROSMAP	Brain Pre-frontal Cortex	MRPS16	0.06	0.03	blup	207	0.03	4.0e-05	8.4	7.0	3.7e-12	0.65	0.05	0.94	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	AP3M1	0.02	0.01	blup	231	0.02	1.3e-03	-7.1	9.9	2.6e-23	0.36	0.08	0.24	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	FUT11	0.09	0.08	lasso	6	0.07	7.6e-10	6.9	-7.5	5.3e-14	-0.48	1.00	0.00	FALSE
44	YFS	Blood	FUT11	0.02	0.00	bslmm	231	0.01	2.0e-03	1.4	5.2	1.8e-07	0.53	0.19	0.40	FALSE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	BMS1P4	0.03	0.03	lasso	4	0.03	2.2e-06	6.7	-7.4	1.3e-13	-0.48	0.83	0.10	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	C10orf55	0.01	0.01	blup	32	0.01	5.0e-03	4.7	-5.7	1.3e-08	-0.44	0.04	0.31	FALSE
47	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SEC24C	0.07	0.07	blup	29	0.07	9.4e-05	8.3	-7.6	2.8e-14	-0.85	0.01	0.96	FALSE
48	The Cancer Genome Atlas	Brain Lower Grade Glioma	FUT11	0.05	0.04	lasso	2	0.04	3.3e-05	6.9	-6.5	9.6e-11	-0.38	0.45	0.09	FALSE
49	The Cancer Genome Atlas	Lung Adenocarcinoma	ADK	0.05	0.06	enet	16	0.07	7.3e-09	5.5	-5.3	1.1e-07	-0.03	0.84	0.16	FALSE
50	The Cancer Genome Atlas	Lung Adenocarcinoma	BMS1P4	0.03	0.01	blup	23	0.01	1.1e-02	6.9	-6.7	2.5e-11	-0.39	0.02	0.11	FALSE
51	The Cancer Genome Atlas	Lung Adenocarcinoma	FUT11	0.03	0.01	blup	27	0.01	2.8e-02	7.0	-8.2	2.5e-16	-0.65	0.02	0.32	FALSE
52	The Cancer Genome Atlas	Lung Adenocarcinoma	SEC24C	0.02	0.01	enet	4	0.01	8.5e-03	8.2	-6.9	6.3e-12	-0.82	0.01	0.80	FALSE
53	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	BMS1P4	0.02	0.01	blup	23	0.01	8.6e-03	6.7	-9.0	2.4e-19	-0.73	0.01	0.50	FALSE
54	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SYNPO2L	0.01	0.02	enet	4	0.02	4.3e-03	8.8	-9.7	3.5e-22	-0.91	0.00	0.76	FALSE
55	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	AP3M1	0.11	0.09	lasso	2	0.10	6.4e-05	5.6	5.7	1.3e-08	0.01	0.21	0.26	FALSE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	NDST2	0.03	0.02	blup	37	0.02	3.3e-03	6.3	7.2	4.8e-13	0.82	0.01	0.96	FALSE
57	The Cancer Genome Atlas	Thyroid Carcinoma	ADK	0.10	0.16	lasso	6	0.15	3.7e-14	5.8	-5.8	7.0e-09	-0.01	0.80	0.20	FALSE
58	The Cancer Genome Atlas	Thyroid Carcinoma	BMS1P4	0.07	0.08	blup	23	0.10	8.3e-10	6.7	-8.9	6.0e-19	-0.73	0.26	0.74	FALSE