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chr10:59,329,755-65,606,229

Best TWAS P=2.69e-19 · Best GWAS P=1.11e-36 conditioned to 1.8e-36

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CISD1	0.06	0.01	bslmm	436	0.02	8.4e-04	-4.2	5.3	1.4e-07	-0.02	0.35	0.04	TRUE
2	CommonMind	Brain Pre-frontal Cortex	TMEM26	0.27	0.15	enet	14	0.27	2.8e-32	4.7	6.1	9.8e-10	-0.16	1.00	0.00	TRUE
3	GTEx	Brain Caudate basal ganglia	BICC1	0.27	0.16	lasso	1	0.16	2.7e-05	-6.7	-6.7	1.6e-11	-0.05	0.03	0.90	TRUE
4	GTEx	Esophagus Mucosa	CCDC6	0.20	0.05	enet	44	0.07	1.7e-05	-5.7	6.0	2.4e-09	-0.04	0.03	0.97	TRUE
5	GTEx	Muscle Skeletal	ADO	0.15	0.16	lasso	8	0.16	1.1e-15	6.1	6.5	7.4e-11	-0.02	1.00	0.00	FALSE
6	GTEx	Muscle Skeletal	RP11-436D10.3	0.08	0.04	enet	13	0.06	3.2e-06	-8.4	8.4	4.8e-17	0.00	0.12	0.88	FALSE
7	GTEx	Skin Sun Exposed Lower leg	NRBF2	0.06	0.01	lasso	3	0.00	4.0e-01	-9.0	8.9	4.6e-19	0.05	0.02	0.74	FALSE
8	GTEx	Testis	RHOBTB1	0.17	0.09	lasso	4	0.16	1.7e-07	-4.8	-5.3	1.3e-07	0.14	0.94	0.00	TRUE
9	GTEx	Testis	ADO	0.21	0.23	lasso	7	0.22	6.6e-10	6.1	-6.2	6.2e-10	0.00	0.99	0.01	FALSE
10	ROSMAP	Brain Pre-frontal Cortex	CCDC6	0.10	0.07	bslmm	601	0.08	5.6e-11	5.8	-5.5	2.9e-08	0.13	0.03	0.97	FALSE
11	ROSMAP	Brain Pre-frontal Cortex	BICC1	0.10	0.09	lasso	10	0.10	2.1e-13	2.5	-5.3	1.3e-07	0.03	0.92	0.08	FALSE
12	ROSMAP	Brain Pre-frontal Cortex	ADO	0.06	0.04	lasso	2	0.06	3.1e-08	-8.4	8.4	5.4e-17	0.06	0.01	0.99	FALSE
13	ROSMAP	Brain Pre-frontal Cortex	TMEM26	0.09	0.05	lasso	5	0.08	1.2e-10	4.8	5.6	1.6e-08	-0.09	0.99	0.00	FALSE
14	YFS	Blood	CCDC6	0.03	0.02	lasso	2	0.01	2.9e-05	5.2	5.2	2.5e-07	-0.04	0.49	0.50	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	ADO	0.03	0.02	blup	53	0.03	1.8e-06	5.2	7.3	4.0e-13	0.08	0.01	0.99	FALSE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ADO	0.10	0.03	enet	6	0.06	4.6e-07	6.3	8.3	8.6e-17	0.02	0.00	1.00	FALSE
17	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	BICC1	0.07	0.00	blup	143	0.02	1.5e-02	-6.8	-6.5	7.4e-11	-0.07	0.02	0.52	FALSE
18	The Cancer Genome Atlas	Brain Lower Grade Glioma	ARID5B	0.05	0.05	lasso	2	0.04	3.7e-05	-5.6	5.6	2.4e-08	-0.01	0.06	0.92	TRUE
19	The Cancer Genome Atlas	Lung Adenocarcinoma	ADO	0.14	0.05	blup	53	0.05	3.8e-06	-9.0	8.8	1.3e-18	0.00	0.00	1.00	FALSE
20	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ADO	0.06	0.04	blup	55	0.01	1.4e-01	-8.4	9.0	2.7e-19	0.08	0.01	0.76	TRUE
21	The Cancer Genome Atlas	Soft Tissue Sarcoma	C10orf107	0.09	0.02	enet	11	0.08	2.0e-05	4.7	5.4	6.6e-08	0.07	0.17	0.04	TRUE
22	The Cancer Genome Atlas	Thyroid Carcinoma	ADO	0.12	0.10	lasso	5	0.09	5.2e-09	-8.4	8.7	3.8e-18	0.02	0.02	0.98	FALSE