[Hub]/) : Traits : Systolic Blood Pressure :

chr10:59,329,755-65,606,229

Best TWAS P=2.69e-19 · Best GWAS P=1.11e-36 conditioned to 1.8e-36

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CISD1 0.06 0.01 bslmm 436 0.02 8.4e-04 -4.2 5.3 1.4e-07 -0.02 0.35 0.04 TRUE
2 CommonMind Brain Pre-frontal Cortex TMEM26 0.27 0.15 enet 14 0.27 2.8e-32 4.7 6.1 9.8e-10 -0.16 1.00 0.00 TRUE
3 GTEx Brain Caudate basal ganglia BICC1 0.27 0.16 lasso 1 0.16 2.7e-05 -6.7 -6.7 1.6e-11 -0.05 0.03 0.90 TRUE
4 GTEx Esophagus Mucosa CCDC6 0.20 0.05 enet 44 0.07 1.7e-05 -5.7 6.0 2.4e-09 -0.04 0.03 0.97 TRUE
5 GTEx Muscle Skeletal ADO 0.15 0.16 lasso 8 0.16 1.1e-15 6.1 6.5 7.4e-11 -0.02 1.00 0.00 FALSE
6 GTEx Muscle Skeletal RP11-436D10.3 0.08 0.04 enet 13 0.06 3.2e-06 -8.4 8.4 4.8e-17 0.00 0.12 0.88 FALSE
7 GTEx Skin Sun Exposed Lower leg NRBF2 0.06 0.01 lasso 3 0.00 4.0e-01 -9.0 8.9 4.6e-19 0.05 0.02 0.74 FALSE
8 GTEx Testis RHOBTB1 0.17 0.09 lasso 4 0.16 1.7e-07 -4.8 -5.3 1.3e-07 0.14 0.94 0.00 TRUE
9 GTEx Testis ADO 0.21 0.23 lasso 7 0.22 6.6e-10 6.1 -6.2 6.2e-10 0.00 0.99 0.01 FALSE
10 ROSMAP Brain Pre-frontal Cortex CCDC6 0.10 0.07 bslmm 601 0.08 5.6e-11 5.8 -5.5 2.9e-08 0.13 0.03 0.97 FALSE
11 ROSMAP Brain Pre-frontal Cortex BICC1 0.10 0.09 lasso 10 0.10 2.1e-13 2.5 -5.3 1.3e-07 0.03 0.92 0.08 FALSE
12 ROSMAP Brain Pre-frontal Cortex ADO 0.06 0.04 lasso 2 0.06 3.1e-08 -8.4 8.4 5.4e-17 0.06 0.01 0.99 FALSE
13 ROSMAP Brain Pre-frontal Cortex TMEM26 0.09 0.05 lasso 5 0.08 1.2e-10 4.8 5.6 1.6e-08 -0.09 0.99 0.00 FALSE
14 YFS Blood CCDC6 0.03 0.02 lasso 2 0.01 2.9e-05 5.2 5.2 2.5e-07 -0.04 0.49 0.50 FALSE
15 The Cancer Genome Atlas Breast Invasive Carcinoma ADO 0.03 0.02 blup 53 0.03 1.8e-06 5.2 7.3 4.0e-13 0.08 0.01 0.99 FALSE
16 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ADO 0.10 0.03 enet 6 0.06 4.6e-07 6.3 8.3 8.6e-17 0.02 0.00 1.00 FALSE
17 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma BICC1 0.07 0.00 blup 143 0.02 1.5e-02 -6.8 -6.5 7.4e-11 -0.07 0.02 0.52 FALSE
18 The Cancer Genome Atlas Brain Lower Grade Glioma ARID5B 0.05 0.05 lasso 2 0.04 3.7e-05 -5.6 5.6 2.4e-08 -0.01 0.06 0.92 TRUE
19 The Cancer Genome Atlas Lung Adenocarcinoma ADO 0.14 0.05 blup 53 0.05 3.8e-06 -9.0 8.8 1.3e-18 0.00 0.00 1.00 FALSE
20 The Cancer Genome Atlas Pancreatic Adenocarcinoma ADO 0.06 0.04 blup 55 0.01 1.4e-01 -8.4 9.0 2.7e-19 0.08 0.01 0.76 TRUE
21 The Cancer Genome Atlas Soft Tissue Sarcoma C10orf107 0.09 0.02 enet 11 0.08 2.0e-05 4.7 5.4 6.6e-08 0.07 0.17 0.04 TRUE
22 The Cancer Genome Atlas Thyroid Carcinoma ADO 0.12 0.10 lasso 5 0.09 5.2e-09 -8.4 8.7 3.8e-18 0.02 0.02 0.98 FALSE