Best TWAS P=2.58e-25 · Best GWAS P=2.99e-33 conditioned to 0
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LRIG2 | 0.05 | 0.01 | bslmm | 358 | 0.03 | 1.0e-04 | -2.9 | 7.5 | 7.3e-14 | 0.07 | 0.16 | 0.03 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | WNT2B | 0.43 | 0.46 | enet | 44 | 0.47 | 7.4e-64 | 8.6 | 9.8 | 1.4e-22 | 0.33 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | WNT2B | 0.10 | 0.10 | enet | 19 | 0.06 | 1.2e-05 | -2.9 | -5.6 | 2.0e-08 | -0.12 | 1.00 | 0.00 | TRUE |
| 4 | GTEx | Artery Aorta | WNT2B | 0.15 | 0.01 | enet | 7 | 0.01 | 1.0e-01 | -7.7 | -7.8 | 4.9e-15 | -0.16 | 0.24 | 0.04 | FALSE |
| 5 | GTEx | Brain Cortex | WNT2B | 0.36 | 0.19 | lasso | 5 | 0.23 | 5.5e-07 | 8.2 | 7.2 | 6.8e-13 | 0.11 | 0.74 | 0.08 | TRUE |
| 6 | GTEx | Brain Frontal Cortex BA9 | WNT2B | 0.29 | 0.28 | lasso | 3 | 0.29 | 2.6e-08 | 8.7 | 7.4 | 1.7e-13 | 0.11 | 0.91 | 0.01 | FALSE |
| 7 | GTEx | Breast Mammary Tissue (Male) | WNT2B | 0.18 | 0.07 | lasso | 6 | 0.05 | 2.3e-02 | -7.6 | -7.4 | 1.5e-13 | -0.16 | 0.08 | 0.05 | FALSE |
| 8 | GTEx | Breast Mammary Tissue (Female) | WNT2B | 0.01 | -0.01 | enet | 24 | 0.00 | 3.4e-01 | 1.8 | -8.0 | 1.1e-15 | -0.11 | 0.03 | 0.05 | FALSE |
| 9 | GTEx | Esophagus Muscularis | SLC16A1 | 0.11 | 0.03 | lasso | 4 | 0.04 | 2.9e-03 | 5.3 | -6.5 | 1.1e-10 | 0.01 | 0.48 | 0.03 | FALSE |
| 10 | GTEx | Heart Left Ventricle | SLC16A1 | 0.08 | 0.05 | lasso | 3 | 0.03 | 7.3e-03 | -6.3 | -5.5 | 3.2e-08 | -0.09 | 0.18 | 0.05 | FALSE |
| 11 | GTEx | Muscle Skeletal | WNT2B | 0.06 | 0.02 | lasso | 7 | 0.03 | 9.4e-04 | -7.6 | -7.6 | 2.7e-14 | -0.14 | 0.56 | 0.02 | FALSE |
| 12 | GTEx | Nerve Tibial | CAPZA1 | 0.17 | 0.16 | lasso | 4 | 0.16 | 2.4e-11 | -7.3 | -6.5 | 1.1e-10 | -0.13 | 1.00 | 0.00 | FALSE |
| 13 | GTEx | Nerve Tibial | RLIMP2 | 0.11 | 0.02 | enet | 42 | 0.04 | 1.5e-03 | -2.8 | -5.1 | 3.0e-07 | -0.05 | 0.22 | 0.03 | FALSE |
| 14 | GTEx | Nerve Tibial | RP4-671G15.2 | 0.07 | 0.06 | lasso | 2 | 0.06 | 2.9e-05 | -7.3 | 7.5 | 5.0e-14 | 0.17 | 0.94 | 0.00 | FALSE |
| 15 | GTEx | Pituitary | ST7L | 0.31 | 0.18 | lasso | 7 | 0.18 | 3.0e-05 | 4.5 | 6.2 | 6.4e-10 | -0.02 | 0.47 | 0.04 | FALSE |
| 16 | GTEx | Skin Not Sun Exposed Suprapubic | SLC16A1 | 0.12 | 0.00 | lasso | 5 | 0.04 | 5.0e-03 | 8.2 | -7.1 | 1.7e-12 | -0.04 | 0.19 | 0.06 | FALSE |
| 17 | GTEx | Skin Sun Exposed Lower leg | MOV10 | 0.05 | 0.02 | lasso | 5 | 0.02 | 1.1e-02 | 8.2 | 7.8 | 5.3e-15 | 0.08 | 0.33 | 0.02 | FALSE |
| 18 | GTEx | Skin Sun Exposed Lower leg | RHOC | 0.07 | 0.02 | lasso | 3 | 0.02 | 1.5e-02 | -7.5 | -7.9 | 3.5e-15 | -0.16 | 0.54 | 0.02 | FALSE |
| 19 | GTEx | Spleen | SLC16A1 | 0.16 | 0.08 | lasso | 5 | 0.07 | 8.3e-03 | -6.3 | -6.8 | 1.4e-11 | -0.04 | 0.11 | 0.16 | FALSE |
| 20 | GTEx | Testis | RLIMP2 | 0.35 | 0.00 | enet | 47 | 0.06 | 1.1e-03 | -2.7 | -5.1 | 3.0e-07 | -0.03 | 0.19 | 0.04 | FALSE |
| 21 | GTEx | Thyroid | CAPZA1 | 0.09 | 0.02 | enet | 22 | 0.03 | 1.7e-03 | -5.5 | -6.8 | 1.3e-11 | -0.20 | 0.42 | 0.04 | FALSE |
| 22 | METSIM | Adipose | SLC16A1 | 0.10 | 0.10 | lasso | 5 | 0.10 | 2.5e-14 | -6.1 | 6.1 | 1.1e-09 | 0.11 | 1.00 | 0.00 | TRUE |
| 23 | ROSMAP | Brain Pre-frontal Cortex | CAPZA1 | 0.05 | 0.06 | lasso | 3 | 0.06 | 1.1e-07 | -7.5 | -7.5 | 6.8e-14 | -0.16 | 1.00 | 0.00 | FALSE |
| 24 | ROSMAP | Brain Pre-frontal Cortex | WNT2B | 0.34 | 0.40 | enet | 30 | 0.42 | 1.5e-59 | 8.2 | 7.5 | 7.2e-14 | 0.20 | 1.00 | 0.00 | FALSE |
| 25 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CTTNBP2NL | 0.04 | 0.00 | blup | 53 | 0.02 | 2.1e-03 | -5.5 | -5.8 | 6.7e-09 | -0.27 | 0.03 | 0.19 | FALSE |
| 26 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | WNT2B | 0.09 | 0.02 | enet | 13 | 0.04 | 5.1e-03 | -7.7 | -7.2 | 6.5e-13 | -0.27 | 0.02 | 0.04 | FALSE |
| 27 | The Cancer Genome Atlas | Lung Adenocarcinoma | SLC16A1 | 0.06 | 0.01 | blup | 38 | 0.02 | 1.4e-03 | -3.1 | 5.8 | 6.6e-09 | 0.08 | 0.01 | 0.68 | FALSE |
| 28 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | SLC16A1 | 0.15 | 0.05 | blup | 38 | 0.05 | 2.4e-04 | -6.4 | 5.3 | 8.8e-08 | 0.11 | 0.00 | 0.99 | FALSE |
| 29 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | WNT2B | 0.05 | 0.02 | blup | 46 | 0.05 | 4.7e-04 | -7.5 | -9.7 | 3.9e-22 | -0.30 | 0.06 | 0.10 | TRUE |
| 30 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SLC16A1 | 0.09 | 0.11 | lasso | 2 | 0.11 | 3.0e-11 | -6.2 | 6.2 | 4.4e-10 | 0.10 | 0.01 | 0.99 | FALSE |
| 31 | The Cancer Genome Atlas | Thyroid Carcinoma | MOV10 | 0.06 | 0.06 | lasso | 7 | 0.05 | 9.4e-06 | 4.5 | 6.7 | 2.7e-11 | 0.05 | 0.47 | 0.43 | FALSE |
| 32 | The Cancer Genome Atlas | Thyroid Carcinoma | RHOC | 0.04 | 0.03 | enet | 9 | 0.04 | 1.4e-04 | -9.0 | -10.4 | 2.6e-25 | -0.30 | 0.14 | 0.44 | TRUE |