Best TWAS P=3.18e-10 · Best GWAS P=3.08e-11 conditioned to 0.00443
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | SIDT2 | 0.07 | 0.06 | lasso | 5 | 0.05 | 8.8e-07 | 5.8 | -6.3 | 3.2e-10 | -0.76 | 0.30 | 0.70 | TRUE |
2 | GTEx | Esophagus Muscularis | PCSK7 | 0.18 | 0.09 | lasso | 3 | 0.10 | 9.2e-07 | 5.9 | -5.1 | 2.9e-07 | -0.72 | 0.47 | 0.52 | FALSE |
3 | GTEx | Pancreas | SIDT2 | 0.17 | 0.12 | lasso | 3 | 0.08 | 1.9e-04 | 5.9 | -5.4 | 7.5e-08 | -0.73 | 0.23 | 0.43 | FALSE |
4 | GTEx | Testis | TAGLN | 0.15 | 0.05 | lasso | 5 | 0.04 | 8.0e-03 | 5.1 | -5.6 | 2.5e-08 | -0.79 | 0.26 | 0.30 | FALSE |
5 | GTEx | Whole Blood | SIDT2 | 0.18 | 0.06 | lasso | 7 | 0.04 | 2.3e-04 | 5.9 | -5.8 | 8.3e-09 | -0.73 | 0.27 | 0.72 | FALSE |
6 | METSIM | Adipose | SIDT2 | 0.09 | 0.07 | lasso | 7 | 0.07 | 2.3e-10 | 5.9 | -5.4 | 7.6e-08 | -0.67 | 0.29 | 0.71 | FALSE |
7 | METSIM | Adipose | TAGLN | 0.04 | 0.04 | lasso | 4 | 0.04 | 2.8e-06 | 5.9 | -5.3 | 8.8e-08 | -0.73 | 0.47 | 0.52 | FALSE |
8 | NTR | Blood | SIDT2 | 0.12 | 0.15 | lasso | 4 | 0.15 | 2.3e-46 | 5.9 | -5.4 | 7.8e-08 | -0.73 | 0.29 | 0.71 | FALSE |
9 | YFS | Blood | SIDT2 | 0.40 | 0.40 | enet | 46 | 0.46 | 1.3e-168 | 5.9 | -5.4 | 6.5e-08 | -0.73 | 0.28 | 0.72 | FALSE |
10 | The Cancer Genome Atlas | Colon Adenocarcinoma | SIDT2 | 0.11 | 0.00 | blup | 46 | 0.05 | 8.2e-04 | 5.9 | -5.4 | 8.0e-08 | -0.64 | 0.01 | 0.67 | FALSE |
11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PCSK7 | 0.04 | 0.03 | lasso | 3 | 0.03 | 5.6e-04 | 5.8 | 5.9 | 3.7e-09 | 0.76 | 0.01 | 0.99 | FALSE |
12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SIDT2 | 0.08 | 0.01 | blup | 46 | 0.05 | 2.4e-06 | 5.1 | -5.4 | 8.3e-08 | -0.59 | 0.07 | 0.58 | FALSE |
13 | The Cancer Genome Atlas | Lung Adenocarcinoma | SIDT2 | 0.02 | 0.01 | blup | 46 | 0.01 | 4.6e-02 | 4.7 | -5.3 | 1.1e-07 | -0.76 | 0.02 | 0.64 | FALSE |