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chr15:73,933,444-76,108,550

Best TWAS P=1.59e-44 · Best GWAS P=7.81e-43 conditioned to 0.049

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MPI	0.13	0.11	blup	277	0.14	1.6e-16	12.13	-11.9	1.9e-32	-0.82	0.99	0.01	FALSE
2	GTEx	Adipose Subcutaneous	ULK3	0.22	0.10	enet	19	0.12	2.9e-10	13.17	9.6	5.7e-22	0.66	0.63	0.37	FALSE
3	GTEx	Adipose Subcutaneous	FAM219B	0.07	0.01	lasso	6	0.02	1.4e-02	9.97	-12.2	1.8e-34	-0.77	0.32	0.27	FALSE
4	GTEx	Adipose Subcutaneous	MPI	0.05	0.05	lasso	7	0.04	6.6e-04	10.37	-10.9	1.2e-27	-0.73	0.23	0.41	FALSE
5	GTEx	Adipose Subcutaneous	CTD-2235H24.2	0.09	0.01	lasso	13	0.01	1.2e-01	12.33	-12.3	1.6e-34	-0.82	0.30	0.19	FALSE
6	GTEx	Adipose Visceral Omentum	ULK3	0.13	0.12	enet	8	0.11	3.3e-06	13.19	13.0	2.0e-38	0.89	0.32	0.67	FALSE
7	GTEx	Adipose Visceral Omentum	FAM219B	0.10	0.02	enet	12	0.07	1.7e-04	-6.16	-6.1	1.4e-09	-0.36	0.09	0.12	FALSE
8	GTEx	Artery Aorta	ARID3B	0.15	0.00	enet	23	0.03	9.6e-03	-3.15	-5.4	5.6e-08	-0.23	0.06	0.14	FALSE
9	GTEx	Artery Tibial	PPCDC	0.11	0.08	enet	8	0.12	1.7e-09	-0.15	7.3	3.5e-13	0.56	0.79	0.19	FALSE
10	GTEx	Artery Tibial	ULK3	0.06	0.04	enet	12	0.03	1.7e-03	13.24	10.6	4.2e-26	0.73	0.14	0.49	FALSE
11	GTEx	Artery Tibial	MPI	0.08	0.03	lasso	5	0.04	8.3e-04	10.37	-9.8	6.8e-23	-0.68	0.37	0.38	FALSE
12	GTEx	Brain Caudate basal ganglia	MPI	0.23	0.25	lasso	4	0.23	3.1e-07	12.45	-12.6	2.3e-36	-0.81	0.11	0.86	FALSE
13	GTEx	Brain Cerebellum	SCAMP2	0.12	0.01	lasso	8	-0.01	5.9e-01	-10.01	-10.1	3.5e-24	-0.73	0.10	0.34	FALSE
14	GTEx	Brain Cerebellum	MPI	0.14	0.09	enet	13	0.09	9.7e-04	-6.15	-10.5	1.2e-25	-0.76	0.11	0.74	FALSE
15	GTEx	Brain Cortex	MPI	0.13	0.04	enet	27	0.06	9.3e-03	12.43	-9.3	1.9e-20	-0.78	0.04	0.75	FALSE
16	GTEx	Brain Frontal Cortex BA9	MPI	0.29	0.12	lasso	10	0.19	9.7e-06	11.68	-13.2	5.3e-40	-0.87	0.04	0.95	FALSE
17	GTEx	Brain Frontal Cortex BA9	ARID3B	0.20	0.13	lasso	6	0.14	2.0e-04	6.27	-5.9	3.3e-09	-0.43	0.15	0.08	FALSE
18	GTEx	Brain Hippocampus	MPI	0.13	0.07	lasso	3	0.06	1.7e-02	12.69	-12.5	6.4e-36	-0.81	0.05	0.30	FALSE
19	GTEx	Brain Nucleus accumbens basal ganglia	MPI	0.33	0.12	enet	29	0.34	8.6e-10	13.04	-11.1	1.0e-28	-0.69	0.07	0.91	FALSE
20	GTEx	Brain Putamen basal ganglia	MPI	0.31	0.18	enet	26	0.23	2.9e-06	12.45	-11.8	4.8e-32	-0.80	0.12	0.85	FALSE
21	GTEx	Breast Mammary Tissue	ULK3	0.15	0.11	lasso	3	0.09	1.6e-05	12.45	12.4	1.8e-35	0.80	0.56	0.41	FALSE
22	GTEx	Breast Mammary Tissue	MPI	0.16	0.00	lasso	8	0.01	1.4e-01	9.82	-10.6	4.0e-26	-0.61	0.05	0.44	FALSE
23	GTEx	Breast Mammary Tissue (Male)	PPCDC	0.07	0.00	enet	8	-0.01	7.9e-01	7.23	10.6	2.5e-26	0.75	0.04	0.15	FALSE
24	GTEx	Breast Mammary Tissue (Male)	ULK3	0.19	0.19	lasso	2	0.15	2.4e-04	11.59	10.8	4.9e-27	0.68	0.07	0.18	FALSE
25	GTEx	Breast Mammary Tissue (Male)	MPI	0.06	0.01	enet	4	0.03	5.7e-02	7.69	-10.9	8.7e-28	-0.59	0.03	0.10	FALSE
26	GTEx	Breast Mammary Tissue (Female)	ULK3	0.08	0.01	lasso	2	0.01	1.8e-01	12.69	12.7	7.1e-37	0.83	0.04	0.21	FALSE
27	GTEx	Cells EBV-transformed lymphocytes	ULK3	0.19	0.04	lasso	2	0.08	1.2e-03	12.43	12.4	1.6e-35	0.82	0.23	0.30	FALSE
28	GTEx	Cells EBV-transformed lymphocytes	SCAMP2	0.26	0.06	lasso	9	0.06	6.2e-03	5.43	-6.7	2.9e-11	-0.50	0.06	0.09	FALSE
29	GTEx	Cells EBV-transformed lymphocytes	MPI	0.25	0.16	lasso	5	0.15	1.5e-05	10.37	-9.3	9.9e-21	-0.69	0.22	0.06	FALSE
30	GTEx	Cells Transformed fibroblasts	ULK3	0.12	0.04	lasso	5	0.10	8.4e-08	12.31	11.8	4.8e-32	0.82	0.90	0.10	FALSE
31	GTEx	Cells Transformed fibroblasts	MPI	0.21	0.16	enet	15	0.22	1.1e-16	11.68	-12.7	7.9e-37	-0.80	0.93	0.07	FALSE
32	GTEx	Colon Sigmoid	PPCDC	0.20	0.15	enet	15	0.14	9.2e-06	2.36	6.3	2.3e-10	0.53	0.40	0.33	FALSE
33	GTEx	Esophagus Mucosa	SCAMP2	0.36	0.20	enet	20	0.27	1.8e-18	10.37	-8.5	2.5e-17	-0.60	1.00	0.00	FALSE
34	GTEx	Esophagus Mucosa	COX5A	0.11	0.02	enet	23	0.03	6.9e-03	11.59	-9.2	3.3e-20	-0.64	0.09	0.34	FALSE
35	GTEx	Esophagus Mucosa	MPI	0.11	0.11	lasso	7	0.10	2.3e-07	10.37	-11.4	5.7e-30	-0.77	0.81	0.19	FALSE
36	GTEx	Esophagus Muscularis	MPI	0.06	0.04	lasso	4	0.04	1.9e-03	-8.56	-8.3	1.2e-16	-0.61	0.38	0.15	FALSE
37	GTEx	Heart Left Ventricle	UBL7	0.06	-0.01	enet	11	0.00	5.5e-01	5.74	-9.4	5.1e-21	-0.70	0.07	0.16	FALSE
38	GTEx	Liver	PPCDC	0.26	0.02	lasso	12	0.01	1.4e-01	9.87	8.2	2.2e-16	0.63	0.08	0.26	FALSE
39	GTEx	Lung	CSK	0.09	0.06	lasso	3	0.05	1.4e-04	13.31	13.6	7.4e-42	0.86	0.26	0.73	FALSE
40	GTEx	Lung	CYP11A1	0.10	0.01	enet	21	0.02	9.5e-03	5.69	-6.6	3.4e-11	-0.52	0.17	0.49	FALSE
41	GTEx	Lung	MPI	0.12	0.08	lasso	5	0.10	8.8e-08	10.37	-9.9	3.7e-23	-0.70	0.99	0.01	FALSE
42	GTEx	Muscle Skeletal	UBL7	0.06	0.02	lasso	6	0.01	3.7e-02	12.84	-13.1	4.7e-39	-0.86	0.06	0.63	FALSE
43	GTEx	Nerve Tibial	PPCDC	0.30	0.00	enet	16	0.08	2.9e-06	3.86	7.4	1.0e-13	0.57	0.21	0.20	FALSE
44	GTEx	Nerve Tibial	UBL7	0.09	0.00	lasso	8	0.03	3.2e-03	9.82	-7.8	6.5e-15	-0.42	0.45	0.16	FALSE
45	GTEx	Nerve Tibial	MPI	0.10	0.12	enet	12	0.15	1.5e-10	9.82	-12.1	1.3e-33	-0.79	0.92	0.08	FALSE
46	GTEx	Ovary	ULK3	0.19	0.23	lasso	1	0.23	3.0e-06	12.69	12.7	7.0e-37	0.83	0.14	0.18	FALSE
47	GTEx	Pancreas	ULK3	0.12	0.10	lasso	4	0.07	6.9e-04	12.43	12.8	1.3e-37	0.85	0.32	0.52	FALSE
48	GTEx	Skin Not Sun Exposed Suprapubic	ULK3	0.12	0.02	enet	14	0.09	1.4e-05	-8.56	5.6	2.1e-08	0.53	0.52	0.06	FALSE
49	GTEx	Skin Not Sun Exposed Suprapubic	SCAMP2	0.36	0.05	enet	31	0.14	5.8e-08	10.37	-6.6	3.7e-11	-0.50	0.34	0.18	FALSE
50	GTEx	Skin Sun Exposed Lower leg	MPI	0.04	0.01	lasso	4	0.02	7.4e-03	9.82	-11.4	4.6e-30	-0.71	0.22	0.65	FALSE
51	GTEx	Spleen	MPI	0.44	0.05	lasso	12	0.02	9.4e-02	-3.15	-5.2	1.6e-07	-0.34	0.07	0.23	FALSE
52	GTEx	Stomach	ULK3	0.16	0.13	lasso	2	0.11	9.7e-06	12.43	12.1	8.1e-34	0.82	0.16	0.82	FALSE
53	GTEx	Testis	ULK3	0.15	0.03	enet	24	0.06	1.6e-03	13.13	9.4	7.7e-21	0.64	0.23	0.58	FALSE
54	GTEx	Testis	SCAMP2	0.37	0.23	enet	30	0.22	3.6e-10	10.37	-8.2	2.6e-16	-0.57	0.98	0.01	FALSE
55	GTEx	Testis	MPI	0.09	0.08	enet	12	0.04	6.0e-03	10.44	-11.6	6.4e-31	-0.75	0.11	0.63	FALSE
56	GTEx	Thyroid	ULK3	0.11	0.09	lasso	4	0.13	5.9e-10	12.69	11.2	3.7e-29	0.77	0.68	0.32	FALSE
57	GTEx	Thyroid	MPI	0.06	0.07	enet	12	0.07	5.1e-06	10.43	-11.3	7.7e-30	-0.78	0.17	0.83	FALSE
58	GTEx	Thyroid	SCAMP5	0.45	0.11	enet	36	0.20	4.6e-15	2.78	5.5	4.4e-08	0.46	1.00	0.00	FALSE
59	GTEx	Uterus	ULK3	0.40	0.16	lasso	16	0.12	2.2e-03	12.33	12.4	2.9e-35	0.80	0.07	0.56	FALSE
60	GTEx	Vagina	COX5A	0.38	0.02	lasso	7	0.02	9.3e-02	13.00	-12.1	8.5e-34	-0.80	0.05	0.52	FALSE
61	GTEx	Whole Blood	ULK3	0.14	0.06	lasso	5	0.04	8.3e-05	12.69	11.8	2.4e-32	0.77	0.74	0.12	FALSE
62	GTEx	Whole Blood	MPI	0.04	0.04	lasso	2	0.01	1.7e-02	12.13	-11.9	7.2e-33	-0.81	0.21	0.17	FALSE
63	METSIM	Adipose	MPI	0.08	0.06	blup	273	0.07	3.1e-11	11.68	-10.3	9.7e-25	-0.68	1.00	0.00	FALSE
64	METSIM	Adipose	RPP25	0.04	0.06	lasso	7	0.05	1.4e-08	10.20	11.3	1.8e-29	0.77	0.46	0.54	FALSE
65	METSIM	Adipose	SCAMP2	0.05	0.02	enet	21	0.07	3.9e-10	-4.76	-6.2	6.6e-10	-0.51	0.77	0.22	FALSE
66	METSIM	Adipose	ULK3	0.14	0.14	lasso	10	0.15	3.2e-22	12.69	13.5	1.3e-41	0.87	0.79	0.21	FALSE
67	NTR	Blood	SCAMP2	0.01	0.01	blup	290	0.01	1.6e-03	-4.42	-7.7	1.6e-14	-0.65	0.18	0.24	FALSE
68	YFS	Blood	COX5A	0.01	0.01	lasso	3	0.01	1.9e-05	-10.15	-9.9	6.1e-23	-0.67	0.85	0.10	FALSE
69	YFS	Blood	CSK	0.13	0.15	lasso	11	0.16	6.7e-51	13.40	14.0	1.6e-44	0.93	0.07	0.93	TRUE
70	YFS	Blood	MPI	0.02	0.02	lasso	4	0.03	1.2e-09	13.04	-12.9	4.9e-38	-0.85	0.19	0.81	FALSE
71	YFS	Blood	SCAMP2	0.04	0.03	blup	287	0.03	6.2e-11	-10.15	-8.3	7.2e-17	-0.58	1.00	0.00	FALSE
72	YFS	Blood	ULK3	0.09	0.11	lasso	6	0.11	1.1e-33	12.69	13.2	1.2e-39	0.87	1.00	0.00	FALSE
73	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MPI	0.09	0.00	blup	36	0.02	7.9e-03	12.14	-10.2	1.8e-24	-0.77	0.01	0.53	FALSE
74	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ULK3	0.06	0.03	enet	6	0.05	6.2e-05	11.23	10.3	8.6e-25	0.65	0.10	0.36	FALSE
75	The Cancer Genome Atlas	Breast Invasive Carcinoma	C15orf17	0.02	0.02	lasso	1	0.02	1.9e-05	11.68	-11.7	1.7e-31	-0.71	0.03	0.95	FALSE
76	The Cancer Genome Atlas	Breast Invasive Carcinoma	MPI	0.04	0.07	enet	13	0.06	5.8e-13	10.37	-11.2	3.1e-29	-0.74	0.98	0.02	FALSE
77	The Cancer Genome Atlas	Breast Invasive Carcinoma	RPP25	0.02	0.01	blup	23	0.02	6.8e-05	12.13	11.0	2.6e-28	0.78	0.00	0.99	FALSE
78	The Cancer Genome Atlas	Breast Invasive Carcinoma	SCAMP2	0.03	0.01	enet	9	0.02	3.2e-05	10.37	-7.2	7.3e-13	-0.54	0.59	0.02	FALSE
79	The Cancer Genome Atlas	Breast Invasive Carcinoma	SEMA7A	0.02	0.00	blup	49	0.01	3.2e-03	4.49	-6.4	1.3e-10	-0.33	0.01	0.65	FALSE
80	The Cancer Genome Atlas	Breast Invasive Carcinoma	ULK3	0.02	0.02	blup	49	0.02	1.1e-05	12.69	13.0	1.4e-38	0.89	0.04	0.95	FALSE
81	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ULK3	0.21	0.02	enet	8	0.07	1.9e-04	13.13	10.7	1.6e-26	0.73	0.01	0.67	FALSE
82	The Cancer Genome Atlas	Colon Adenocarcinoma	MPI	0.07	0.03	blup	36	0.04	2.1e-03	12.13	-12.4	1.7e-35	-0.83	0.01	0.95	FALSE
83	The Cancer Genome Atlas	Colon Adenocarcinoma	SCAMP2	0.06	0.04	blup	56	0.01	9.4e-02	10.60	-7.8	4.5e-15	-0.60	0.05	0.28	FALSE
84	The Cancer Genome Atlas	Glioblastoma Multiforme	MPI	0.11	0.03	blup	36	0.02	8.4e-02	12.13	-12.6	2.1e-36	-0.83	0.01	0.74	FALSE
85	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MPI	0.02	0.01	blup	36	0.01	1.2e-02	11.59	-12.1	1.4e-33	-0.79	0.02	0.55	FALSE
86	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CSK	0.02	0.00	blup	57	0.01	1.8e-02	13.28	11.8	2.2e-32	0.74	0.02	0.49	FALSE
87	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MPI	0.04	0.04	enet	2	0.03	7.8e-05	-10.01	-10.1	4.0e-24	-0.71	0.80	0.10	FALSE
88	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RPP25	0.04	0.07	lasso	3	0.06	2.2e-07	-8.56	9.2	5.8e-20	0.66	0.95	0.04	FALSE
89	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ULK3	0.03	0.03	lasso	3	0.03	5.3e-04	12.33	12.9	5.5e-38	0.86	0.05	0.91	FALSE
90	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MPI	0.06	0.04	blup	35	0.05	8.5e-04	12.45	-12.4	1.7e-35	-0.81	0.01	0.94	FALSE
91	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RPP25	0.05	0.03	blup	23	0.04	3.7e-03	-8.56	10.4	2.8e-25	0.73	0.01	0.77	FALSE
92	The Cancer Genome Atlas	Brain Lower Grade Glioma	MPI	0.07	0.09	lasso	4	0.10	2.4e-11	11.59	-12.2	4.1e-34	-0.80	0.02	0.98	FALSE
93	The Cancer Genome Atlas	Brain Lower Grade Glioma	SCAMP2	0.18	0.04	enet	5	0.06	6.1e-07	13.72	-11.3	9.3e-30	-0.85	0.00	1.00	FALSE
94	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ULK3	0.10	0.02	blup	49	0.07	2.5e-04	13.19	11.7	2.2e-31	0.76	0.12	0.82	FALSE
95	The Cancer Genome Atlas	Lung Adenocarcinoma	C15orf17	0.02	0.03	lasso	1	0.02	1.5e-03	11.68	-11.7	1.6e-31	-0.72	0.01	0.83	FALSE
96	The Cancer Genome Atlas	Lung Adenocarcinoma	MPI	0.02	0.02	lasso	1	0.02	4.7e-03	10.60	-10.6	2.8e-26	-0.72	0.06	0.77	FALSE
97	The Cancer Genome Atlas	Lung Adenocarcinoma	ULK3	0.03	0.00	blup	50	0.00	8.1e-02	11.68	9.4	5.2e-21	0.58	0.04	0.12	FALSE
98	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MPI	0.04	0.03	blup	36	0.05	8.8e-07	11.68	-12.0	2.0e-33	-0.79	0.06	0.94	FALSE
99	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ULK3	0.04	0.06	lasso	4	0.04	7.6e-06	12.33	12.8	2.7e-37	0.85	0.03	0.97	FALSE
100	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MPI	0.09	0.07	blup	36	0.08	3.9e-06	-10.15	-10.6	1.9e-26	-0.71	0.82	0.15	FALSE
101	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C15orf17	0.06	0.06	enet	25	0.02	6.1e-02	10.45	-7.0	3.7e-12	-0.64	0.02	0.58	FALSE
102	The Cancer Genome Atlas	Prostate Adenocarcinoma	MPI	0.07	0.07	blup	36	0.10	3.3e-10	10.37	-11.6	2.9e-31	-0.75	0.24	0.76	FALSE
103	The Cancer Genome Atlas	Soft Tissue Sarcoma	ULK3	0.04	0.03	blup	49	0.02	3.3e-02	12.45	8.6	5.8e-18	0.51	0.03	0.16	FALSE
104	The Cancer Genome Atlas	Stomach Adenocarcinoma	COX5A	0.03	0.03	blup	32	0.03	2.9e-03	-8.56	-11.0	2.8e-28	-0.72	0.05	0.27	FALSE
105	The Cancer Genome Atlas	Stomach Adenocarcinoma	MPI	0.04	0.02	blup	36	0.03	1.7e-03	11.69	-11.9	1.1e-32	-0.77	0.14	0.46	FALSE
106	The Cancer Genome Atlas	Stomach Adenocarcinoma	SCAMP2	0.04	0.05	lasso	2	0.05	2.0e-04	-10.01	-10.1	6.7e-24	-0.70	0.20	0.47	FALSE
107	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MPI	0.12	0.11	lasso	7	0.12	5.3e-05	11.59	-11.9	1.1e-32	-0.75	0.12	0.71	FALSE
108	The Cancer Genome Atlas	Thyroid Carcinoma	CSK	0.04	0.04	blup	57	0.04	4.6e-05	13.18	10.2	2.2e-24	0.57	0.18	0.62	FALSE
109	The Cancer Genome Atlas	Thyroid Carcinoma	MPI	0.13	0.18	enet	10	0.16	3.7e-15	10.45	-11.7	1.6e-31	-0.77	0.97	0.03	FALSE
110	The Cancer Genome Atlas	Thyroid Carcinoma	ULK3	0.08	0.11	lasso	5	0.10	4.6e-10	12.33	12.8	2.6e-37	0.86	0.23	0.77	FALSE