Best TWAS P=2.93e-70 · Best GWAS P=1.2e-58 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FURIN | 0.12 | 0.14 | lasso | 2 | 0.13 | 1.2e-15 | -12.3 | 12.3 | 1.5e-34 | 0.62 | 1.00 | 0.00 | TRUE |
| 2 | GTEx | Adipose Visceral Omentum | FES | 0.21 | 0.09 | lasso | 5 | 0.05 | 1.3e-03 | 16.1 | -16.0 | 1.7e-57 | -0.99 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Artery Tibial | FES | 0.16 | 0.04 | lasso | 5 | 0.05 | 4.8e-05 | 14.6 | -16.6 | 4.7e-62 | -0.89 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Male) | RCCD1 | 0.33 | -0.01 | enet | 28 | 0.07 | 1.3e-02 | 15.9 | 7.5 | 6.2e-14 | 0.28 | 0.04 | 0.32 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | FES | 0.28 | 0.17 | enet | 21 | 0.20 | 2.8e-15 | 16.1 | -17.7 | 2.9e-70 | -0.92 | 0.00 | 1.00 | TRUE |
| 6 | GTEx | Lung | FES | 0.24 | 0.07 | lasso | 6 | 0.05 | 5.1e-05 | 14.6 | -16.8 | 2.8e-63 | -0.90 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | FES | 0.09 | 0.04 | lasso | 5 | 0.04 | 1.4e-04 | 16.1 | -14.6 | 2.8e-48 | -0.91 | 0.00 | 0.99 | FALSE |
| 8 | GTEx | Thyroid | FES | 0.33 | 0.19 | lasso | 6 | 0.18 | 4.3e-14 | 15.2 | -15.4 | 2.1e-53 | -0.95 | 0.01 | 0.99 | FALSE |
| 9 | METSIM | Adipose | FES | 0.08 | 0.06 | lasso | 3 | 0.05 | 6.8e-08 | 14.6 | -14.2 | 8.1e-46 | -0.88 | 0.14 | 0.86 | FALSE |
| 10 | METSIM | Adipose | UNC45A | 0.14 | 0.10 | lasso | 8 | 0.11 | 5.1e-16 | -5.4 | -5.5 | 4.2e-08 | -0.16 | 1.00 | 0.00 | FALSE |
| 11 | YFS | Blood | FES | 0.31 | 0.11 | enet | 77 | 0.22 | 1.2e-68 | 16.1 | -14.0 | 2.0e-44 | -0.61 | 0.00 | 1.00 | FALSE |
| 12 | YFS | Blood | FURIN | 0.11 | 0.03 | enet | 37 | 0.06 | 8.3e-19 | -12.3 | -10.6 | 4.1e-26 | -0.48 | 0.13 | 0.87 | FALSE |
| 13 | YFS | Blood | MAN2A2 | 0.16 | 0.06 | lasso | 8 | 0.13 | 1.9e-39 | -3.3 | 5.5 | 3.7e-08 | 0.21 | 1.00 | 0.00 | FALSE |
| 14 | YFS | Blood | UNC45A | 0.02 | 0.00 | bslmm | 483 | 0.00 | 8.8e-03 | -3.4 | -5.6 | 2.8e-08 | -0.12 | 0.12 | 0.02 | TRUE |
| 15 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | FES | 0.06 | 0.05 | blup | 46 | 0.06 | 1.9e-05 | 16.0 | -15.7 | 2.5e-55 | -0.74 | 0.01 | 0.97 | FALSE |
| 16 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | HDDC3 | 0.05 | 0.03 | blup | 59 | 0.03 | 1.3e-03 | -5.0 | -7.5 | 5.3e-14 | -0.33 | 0.03 | 0.09 | FALSE |
| 17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FES | 0.06 | 0.05 | blup | 46 | 0.07 | 7.4e-14 | 16.1 | -16.9 | 5.9e-64 | -0.88 | 0.00 | 1.00 | FALSE |
| 18 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | FES | 0.06 | 0.02 | blup | 46 | 0.02 | 2.4e-02 | 16.1 | -14.3 | 2.1e-46 | -0.81 | 0.00 | 0.90 | TRUE |
| 19 | The Cancer Genome Atlas | Colon Adenocarcinoma | FES | 0.08 | 0.07 | blup | 46 | 0.06 | 3.4e-04 | 15.3 | -16.0 | 2.2e-57 | -0.84 | 0.03 | 0.93 | TRUE |
| 20 | The Cancer Genome Atlas | Glioblastoma Multiforme | FES | 0.12 | 0.06 | enet | 6 | 0.06 | 5.7e-03 | 16.0 | -16.4 | 3.3e-60 | -0.80 | 0.01 | 0.85 | FALSE |
| 21 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FES | 0.06 | 0.03 | blup | 46 | 0.05 | 5.6e-06 | 16.0 | -15.3 | 6.3e-53 | -0.78 | 0.01 | 0.99 | TRUE |
| 22 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FES | 0.10 | 0.07 | enet | 5 | 0.05 | 2.8e-06 | 15.9 | -15.6 | 4.0e-55 | -0.70 | 0.03 | 0.97 | TRUE |
| 23 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | HDDC3 | 0.16 | 0.10 | enet | 9 | 0.12 | 2.1e-07 | 3.0 | -6.7 | 2.3e-11 | -0.38 | 0.76 | 0.09 | TRUE |
| 24 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | UNC45A | 0.21 | 0.07 | blup | 67 | 0.11 | 6.8e-07 | -3.4 | -7.0 | 3.7e-12 | -0.22 | 0.63 | 0.04 | FALSE |
| 25 | The Cancer Genome Atlas | Lung Adenocarcinoma | FES | 0.05 | 0.04 | lasso | 2 | 0.04 | 2.2e-05 | 16.1 | -17.3 | 8.7e-67 | -0.95 | 0.00 | 1.00 | FALSE |
| 26 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FES | 0.08 | 0.07 | enet | 7 | 0.08 | 4.2e-09 | 16.1 | -16.5 | 6.4e-61 | -0.93 | 0.00 | 1.00 | FALSE |
| 27 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | FES | 0.13 | 0.16 | lasso | 2 | 0.14 | 6.1e-10 | 16.1 | -16.0 | 1.7e-57 | -0.99 | 0.00 | 1.00 | FALSE |
| 28 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FES | 0.12 | 0.09 | lasso | 5 | 0.08 | 4.1e-09 | 16.1 | -17.6 | 4.2e-69 | -0.95 | 0.00 | 1.00 | FALSE |
| 29 | The Cancer Genome Atlas | Stomach Adenocarcinoma | FES | 0.04 | 0.01 | blup | 46 | 0.02 | 1.7e-02 | 16.0 | -14.1 | 2.1e-45 | -0.75 | 0.01 | 0.60 | FALSE |
| 30 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | FES | 0.32 | 0.26 | lasso | 2 | 0.25 | 2.0e-09 | 16.0 | -16.0 | 7.9e-58 | -0.96 | 0.00 | 1.00 | FALSE |
| 31 | The Cancer Genome Atlas | Thyroid Carcinoma | FES | 0.30 | 0.30 | lasso | 7 | 0.32 | 1.3e-31 | 16.0 | -17.5 | 1.3e-68 | -0.95 | 0.00 | 1.00 | FALSE |
| 32 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | HDDC3 | 0.13 | 0.08 | lasso | 1 | 0.09 | 2.0e-03 | -5.4 | -5.4 | 7.8e-08 | -0.13 | 0.06 | 0.05 | FALSE |