Hub : Genes

MAN2A2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellum 0.2940 0.0880 0.00038 0.288 NA 0.220 NA 0.159 3.6e-09 NA 4.0e-07 NA 2.0e-05
2 GTEx Muscle Skeletal 0.1503 0.0567 0.00250 0.008 NA 0.021 NA 0.027 5.0e-02 NA 3.5e-03 NA 1.1e-03
3 GTEx Testis 0.2740 0.0920 0.00150 0.104 NA 0.039 NA 0.098 2.4e-05 NA 7.7e-03 NA 4.1e-05
4 METSIM Adipose 0.0413 0.0167 0.00180 -0.001 0.013 -0.001 0.011 -0.002 6.0e-01 3.4e-03 4.5e-01 7.1e-03 7.7e-01
5 YFS Blood 0.1626 0.0290 0.00000 0.061 0.095 0.118 0.111 0.127 2.3e-19 1.9e-29 1.3e-36 3.4e-34 1.9e-39
6 TCGA Brain Lower Grade Glioma 0.0508 0.0291 0.00460 0.033 0.010 0.018 NA 0.024 1.1e-04 2.6e-02 3.0e-03 NA 8.2e-04
7 TCGA Prostate Adenocarcinoma 0.0286 0.0164 0.00570 0.027 0.025 0.020 NA 0.021 7.7e-04 1.0e-03 3.0e-03 NA 2.7e-03
8 TCGA Thyroid Carcinoma 0.0480 0.0260 0.00290 0.012 0.009 -0.001 NA 0.007 2.2e-02 4.2e-02 4.4e-01 NA 5.6e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 0.1 0.1 0.5 -0.2 -0.3 0.0 -0.2 -0.7 0.2 -0.1 -0.1
Bipolar Disorder or Schizophrenia 2.1 5.1 10.9 1.9 2.0 -2.7 0.8 -3.3 0.7 2.7 2.6
Depressed Affect (Nagel 2018) 0.8 1.7 3.5 -1.1 -1.3 1.5 -1.6 0.4 0.1 -1.9 -1.6
Depression (Nagel 2018) 1.2 1.8 4.7 -1.8 -0.8 1.6 -2.2 -0.5 1.1 -1.3 -0.4
Intelligence (Savage-Jansen 2018) 0.3 0.9 2.5 -0.1 -1.6 0.3 -0.0 1.4 -1.1 -1.3 -0.4
Neuroticism (Nagel 2018) 0.7 1.7 4.0 -0.6 -2.0 1.0 -1.6 0.4 -0.6 -1.6 -1.6
Schizophrenia (2018) 3.8 7.8 12.7 2.5 2.7 -3.5 1.3 -3.1 0.7 3.6 3.4
Schizophrenia vs Biploar Disorder 0.2 0.2 1.0 0.5 1.0 -0.3 0.1 0.1 -0.7 -0.1 -0.1
Worry (Nagel 2018) 1.2 2.6 4.7 -0.6 -2.0 1.0 -1.9 1.3 -1.2 -2.2 -1.9
Alzheimer’s Disease (in mother) 1.0 1.1 2.6 -1.1 -1.2 1.5 -1.6 0.2 0.4 -0.9 -0.6
Alzheimer’s Disease (in father) 1.3 1.4 4.6 -1.7 0.5 1.2 -1.2 -0.6 2.1 0.0 -0.2
Alzheimer’s Disease (including proxy) 1.7 2.4 5.5 -2.2 -1.0 1.9 -2.3 -0.4 2.0 -0.5 -0.4
Crohns Disease (2017) 0.3 0.6 1.5 0.5 -0.8 -0.0 -0.8 0.6 -1.2 -1.0 -0.4
Irritable Bowel Disease (IBD) 0.1 0.2 0.9 0.5 0.2 -0.3 0.6 0.9 -0.4 -0.1 0.3
Ulcerative Colitis (UC) 0.2 0.3 1.1 -0.1 0.8 -0.1 1.0 0.6 0.4 0.4 0.4
Major Depression (MDD) 0.3 0.4 1.7 -0.4 0.5 0.8 1.3 -0.0 0.0 0.0 0.0
Reaction Time 0.2 0.5 2.1 -0.3 0.2 -0.1 -1.4 -0.4 0.8 0.6 0.4
Verbal and Numeric Reasoning (VNR) 0.5 1.1 3.1 0.0 -0.6 0.5 0.4 1.8 -1.4 -1.6 -0.9
Breast Cancer 4.7 11.4 25.5 -3.3 -3.1 4.2 -1.6 2.1 -1.1 -5.1 -4.4
Ovarian Cancer 2.1 2.8 6.7 -1.1 -2.1 2.0 0.7 1.9 -0.4 -2.6 -1.5
Prostate Cancer 0.2 0.3 1.7 -0.1 -0.5 0.1 1.3 -0.1 0.7 -0.1 -0.3
Age at First Birth 1.5 2.1 4.3 2.1 1.7 -1.6 1.8 -0.2 -1.7 0.9 0.7
Bipolar Disorder (2011) 1.0 1.0 2.5 0.9 -0.0 -1.1 -1.0 -1.1 -0.4 1.1 1.6
Body Mass Index (BMI) (2010) 0.3 0.4 2.7 -0.1 1.6 -0.1 -0.3 0.3 0.6 -0.3 -0.1
Coronary Artery Disease (CAD) 1.1 1.3 2.9 -0.6 -0.1 0.1 -1.0 -1.3 1.4 1.5 1.7
Crohns Disease (2012) 0.9 1.4 4.4 0.6 -1.6 -0.0 -0.2 2.1 -1.2 -1.5 -0.3
Mean Putamen Volume 3.2 3.7 8.2 0.6 1.0 -1.5 1.9 -2.9 1.0 2.4 2.7
Fasting Glucose 2.3 2.8 7.3 -2.2 0.7 1.7 -2.7 0.3 0.9 -2.1 -1.2
HbA1C 0.6 0.7 4.5 0.2 2.1 -0.5 0.4 -0.1 0.1 0.2 0.7
HDL Cholesterol 0.4 0.6 1.8 0.7 -0.9 -0.1 1.2 0.6 -1.3 0.1 -0.4
LDL Cholesterol 1.1 1.7 3.5 1.8 1.9 -1.7 0.6 -0.2 -1.5 1.0 0.7
Lupus 0.9 1.3 3.5 -0.6 -0.5 0.2 -0.7 -1.9 1.4 1.1 1.6
Neuroticism (2016) 0.6 0.8 3.7 -0.8 -0.5 1.1 -1.9 -0.4 0.9 -0.4 0.0
Primary Biliary Cirrhosis 0.6 0.9 2.0 -0.3 -0.2 -0.6 -0.3 -1.4 1.3 1.1 1.3
Rheumatoid Arthritis 0.3 0.5 1.4 0.8 -1.1 -0.4 0.2 -0.0 -1.2 0.2 -0.2
Schizophrenia (2014) 1.7 3.7 7.1 1.9 2.1 -2.7 1.2 -2.3 0.0 1.9 2.0
Triglycerides 1.4 2.2 5.4 2.2 1.4 -2.3 0.6 -0.4 -1.4 0.8 1.6
Type 2 Diabetes (T2D) (2012) 4.0 4.6 13.0 -3.6 -1.4 2.9 -2.2 -0.5 2.2 -1.5 -1.0
Ulcerative Colitis 0.2 0.2 0.5 -0.5 0.5 0.5 0.5 0.4 0.7 0.3 0.4
Blood Eosinophil Count 0.7 5.2 15.6 -3.0 -1.2 2.4 -4.0 -0.9 3.0 -0.1 0.1
Blood Platelet Count 1.4 16.2 47.6 2.5 2.9 -3.8 2.1 -3.5 2.6 6.9 5.4
Blood Red Count 0.0 0.4 1.3 -0.1 -0.6 -0.1 1.1 1.1 -0.2 -0.1 0.6
Blood White Count 0.1 0.5 1.5 0.7 0.1 -0.5 0.2 0.7 0.4 1.2 1.2
Heel T-Score 0.6 4.5 8.4 -1.6 -2.6 2.5 -2.3 1.0 -0.7 -2.9 -2.2
BMI 0.2 1.0 2.8 -1.2 -0.8 -0.2 -0.2 -0.8 1.7 0.8 1.3
Height 0.2 3.2 6.1 2.4 1.4 -2.5 1.5 -0.6 -0.2 1.8 2.5
Waist Hip Ratio (WHR) 0.3 1.2 2.0 0.8 1.1 -1.3 -0.9 -1.2 0.2 1.3 1.4
Systolic Blood Pressure 2.0 9.8 30.2 2.7 -1.7 -0.7 2.9 5.5 -4.6 -2.5 -1.6
Smoking Status 1.0 2.4 10.9 -1.7 -0.8 0.9 -3.3 -1.3 1.5 0.6 0.5
Allergy or Eczema 1.4 3.7 27.3 -0.2 -0.8 0.5 -5.2 -0.2 0.5 0.6 0.7
Cardiovascular Disease 0.3 0.8 4.6 -0.1 -0.9 0.2 0.1 2.1 -0.9 -0.7 -0.0
Hypothyroidism (self reported) 0.9 2.1 5.0 -0.8 -1.0 1.6 -1.2 1.1 -1.2 -2.2 -1.9
Respiratory disease 1.8 4.0 9.4 -2.3 0.3 1.3 -2.8 -2.6 3.1 0.7 0.5
Type 2 Diabetes (T2D) (2018) 1.1 2.0 4.3 -2.1 -1.6 1.7 -1.9 0.0 1.1 -1.1 -0.2
Lung FEV1/FVC ratio 0.1 0.3 1.6 0.1 1.3 -0.6 0.5 -0.5 0.1 -0.2 -0.0
Lung FVC 0.0 0.2 1.1 0.1 -1.1 0.1 0.1 -0.3 -0.3 -0.3 0.3
Neuroticism 1.2 2.9 7.3 -1.5 -2.0 1.8 -2.7 0.1 0.3 -2.0 -1.7
Chronotype (morning person) 0.3 0.7 2.5 1.2 0.0 -0.6 0.8 0.5 -1.6 -0.1 -0.3
Hair Pigment 0.0 1.3 4.4 1.1 1.6 -2.1 -0.1 -0.7 0.4 1.4 0.3
Tanning 0.2 1.9 4.6 -2.1 -0.4 2.1 -1.8 -0.1 0.8 -1.4 -0.9
Hand grip strength (left) 0.2 0.4 1.1 -0.4 0.1 0.2 0.8 0.6 -0.5 -1.0 -0.9
Number of treatments/medications taken 2.5 4.5 10.1 -3.2 -3.1 2.8 -1.5 0.7 1.7 -1.6 -0.5
Average weekly spirits intake 1.3 1.6 3.8 1.3 0.4 -1.3 0.8 -2.0 -0.1 1.4 1.6
Sensitivity / hurt feelings 0.4 0.6 2.4 -0.8 -0.8 0.5 -0.0 -1.5 0.9 0.6 0.3
Frequency of depressed mood in last 2 weeks 0.5 0.7 2.0 -1.0 0.8 0.1 -0.5 -1.1 1.4 -0.1 0.3
Hearing difficulty/problems: Yes 0.2 0.4 1.1 0.4 0.5 -0.4 0.0 0.4 0.6 1.0 1.0
Relative age of first facial hair 0.7 1.4 3.6 -0.4 1.0 -0.1 -1.2 -1.6 1.9 1.2 0.8
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.7 0.7 -0.8 -0.7 0.4 -0.3 -0.8 0.5 0.4
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.8 0.1 -0.2 -0.1 -0.6 -0.9 -0.2 0.1 0.6
Ever had hysterectomy (womb removed) 0.6 0.6 1.9 0.1 -0.9 0.3 0.8 -0.8 -1.4 -0.6 -0.8
Systolic blood pressure, automated reading 2.2 6.5 16.6 2.1 -2.7 -0.4 1.8 3.8 -4.1 -2.0 -1.2
Eye problems/disorders: Diabetes related eye disease 1.8 2.0 3.6 -0.7 -1.9 1.1 -1.3 1.8 -1.2 -1.4 -1.6
Angina 1.4 1.8 4.7 -0.2 -2.2 0.7 -0.9 1.9 -1.3 -1.6 -0.8
Medication for hormone replacement therapy 1.0 1.1 1.9 -1.1 0.2 0.1 -0.9 -1.4 1.1 1.4 1.2
Vitamin and mineral supplements 0.7 0.9 2.3 1.5 1.5 -1.4 -0.1 0.2 -0.8 -0.1 0.3
Supplements: Zinc 1.1 1.2 2.5 -1.2 0.2 1.2 0.5 1.6 0.5 -0.9 -1.6
Medication: Co-codamol 0.3 0.4 1.3 -0.8 -0.0 0.4 1.1 0.4 0.7 -0.3 -0.1
Medication: Metformin 2.2 3.1 9.2 -1.8 -2.7 1.8 -3.0 -0.4 1.0 -0.9 -0.0
Diabetes (father) 3.8 4.8 8.7 -3.0 -1.5 2.8 -2.4 0.4 1.8 -2.5 -2.0
Diabetes (mother) 1.6 2.0 6.4 -2.5 -0.3 1.5 -1.8 -0.3 1.4 -1.1 -0.8
Severe depression (siblings) 1.6 1.8 3.8 -0.9 -1.4 1.4 -0.8 1.6 -0.5 -1.9 -1.5
Pack years adult smoking proportion 0.5 0.8 3.8 -1.0 0.6 0.5 -0.6 0.3 1.9 0.4 0.5
Impedance of leg (right) 0.6 3.0 11.2 2.1 0.2 -0.9 0.7 3.4 -2.5 -0.9 -0.5
Leg fat-free mass (left) 0.3 1.4 3.5 -0.9 -0.2 -0.4 -0.0 -1.6 1.9 1.2 1.7
Trunk fat percentage 0.3 1.1 3.2 -0.5 -1.0 -0.4 0.1 -0.7 1.7 1.0 1.8
Hand grip strength (right) 0.4 1.1 2.4 -1.3 0.0 1.4 0.5 0.4 -0.0 -1.5 -1.6
Townsend deprivation index at recruitment 1.2 1.6 5.2 -1.0 -0.4 -0.1 -2.0 -0.4 2.3 1.0 1.2
Current tobacco smoking 0.5 0.8 3.0 -0.8 -1.5 0.5 -1.7 -0.0 -0.1 0.3 0.5
Average weekly fortified wine intake 0.4 0.5 1.2 -0.7 -0.0 0.7 0.4 -1.1 1.1 -0.1 0.3
Maternal smoking around birth 0.7 1.0 2.6 -1.5 -0.0 1.6 -1.1 -0.5 1.0 -0.5 -0.7
Fed-up feelings 0.0 0.1 0.2 -0.1 -0.5 -0.2 -0.4 -0.0 0.3 0.0 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 1.6 -0.9 -0.4 0.1 -1.3 -0.6 1.1 0.1 0.7
Relative age voice broke 1.3 1.9 4.9 -0.0 2.1 -0.7 -0.0 -2.2 1.6 1.6 0.7
Taking other prescription medications 2.6 4.0 10.5 -2.5 -3.2 2.1 -2.6 0.4 1.1 -1.7 -0.3
Age when periods started (menarche) 0.2 0.5 1.5 0.7 1.2 -0.8 0.9 0.1 -0.7 0.4 0.1
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.4 -0.2 -0.6 0.1 -0.6 0.1 -0.4 -0.2 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.8 3.4 0.3 -1.3 0.8 -1.5 0.9 -1.8 -1.8 -1.5
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 1.9 0.0 0.1 -0.4 0.2 1.1 0.2 0.9 1.4
Qualifications: CSEs or equivalent 0.9 1.2 4.2 -0.7 0.3 0.4 -1.4 2.1 0.5 -1.1 -1.1
Serious illness, injury or assault to yourself 0.2 0.3 1.2 -0.1 0.0 0.1 1.1 -0.6 0.4 0.5 0.3
High blood pressure 0.7 1.9 6.2 0.4 -2.5 -0.1 -0.4 2.5 -1.4 -0.6 0.6
Hayfever, allergic rhinitis or eczema 1.5 3.3 22.8 -0.8 -0.5 0.9 -4.8 -0.6 1.2 0.2 0.4
Multivitamins +/- minerals 0.5 0.7 1.5 -1.0 -0.9 0.6 0.6 -1.2 0.7 0.9 0.4
Stomach or abdominal pain in last month 3.9 4.8 10.7 -3.3 -2.9 3.0 -2.2 0.4 1.9 -1.1 -0.7
Supplements: Glucosamine 1.2 1.6 3.9 -1.2 -2.0 1.9 0.5 0.7 -0.1 -1.4 -1.2
Diverticular disease/diverticulitis (self-reported) 2.0 2.3 8.0 -1.2 -1.9 1.9 -2.8 -0.7 0.1 -1.0 -0.8
Medication: Atenolol 1.3 1.6 8.5 1.0 -1.2 -0.2 0.2 2.9 -1.3 -0.8 0.0
Medication: Levothyroxine sodium 0.8 1.4 3.2 -0.3 -1.1 0.8 -0.0 1.7 -1.3 -1.8 -1.1
Sitting height 0.1 0.6 2.3 0.7 -0.7 -0.8 0.3 0.1 -0.1 0.6 1.5
Chronic bronchitis/emphysema (father) 0.6 0.7 2.1 -0.9 0.2 0.6 1.4 -0.2 1.0 -0.9 -0.7
High blood pressure (mother) 1.6 2.3 5.4 -0.6 -1.8 1.3 0.7 1.7 -1.7 -2.3 -1.2
Body mass index (BMI) 0.3 1.2 2.6 -1.5 -1.5 0.6 -0.3 -0.9 1.6 0.3 0.8
Impedance of leg (left) 0.6 2.7 10.1 2.0 0.6 -1.1 0.8 3.2 -2.2 -0.6 -0.3
Leg predicted mass (left) 0.3 1.4 3.6 -0.9 -0.2 -0.3 -0.0 -1.5 1.9 1.2 1.6
Trunk fat mass 0.3 1.3 3.9 -0.5 -1.0 -0.5 0.1 -0.8 1.8 1.1 2.0
Waist circumference 0.3 1.0 3.6 -0.5 -1.0 -0.3 0.4 -0.8 1.2 1.0 1.9
Number of incorrect matches in round 1.2 2.0 6.3 -1.3 0.2 -0.3 -1.3 -0.8 2.5 1.2 2.0
Past tobacco smoking 0.1 0.3 0.9 -0.2 0.2 0.1 0.9 0.8 0.1 -0.3 -0.6
Alcohol usually taken with meals 0.2 0.4 0.8 0.1 0.3 0.6 0.9 0.3 -0.7 -0.8 -0.7
Nervous feelings 0.6 1.0 2.1 0.7 -0.5 -0.2 0.3 1.4 -1.4 -1.1 -1.4
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 3.2 -1.8 0.9 1.4 -0.4 -0.2 1.5 -1.1 -1.2
Hearing difficulty/problems with background noise 0.2 0.4 1.4 -0.1 -1.2 0.7 -0.7 0.3 -0.1 -0.7 -0.5
Hair/balding pattern: Pattern 2 0.1 0.2 0.9 -0.0 1.0 0.3 -0.0 -0.2 0.5 0.2 -0.3
Had menopause 0.3 0.4 2.2 0.3 0.3 0.0 0.4 -0.1 -1.5 -0.7 -0.4
Had other major operations 1.1 1.4 3.5 -1.9 -0.1 1.6 -1.6 -0.4 1.4 -0.5 -0.2
Forced vital capacity (FVC) 0.1 0.3 0.8 -0.2 -0.3 0.4 -0.3 0.7 -0.3 -0.9 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 2.8 -0.1 -1.3 1.0 -1.3 0.7 -1.5 -1.7 -1.3
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 0.9 0.5 0.9 -1.0 -0.1 -0.3 -0.1 0.5 0.8
Qualifications: None of the above 0.2 0.4 1.0 -0.4 -1.0 0.7 0.8 -1.0 -0.1 -0.1 -0.3
Financial difficulties in last 2 years 1.6 2.1 6.0 -1.1 1.4 0.0 -2.4 -1.2 1.9 1.2 1.1
Mouth/teeth dental problems 0.5 0.8 3.2 0.1 0.1 -0.5 1.8 0.6 -0.5 -1.3 -0.6
Heart attack 0.4 0.6 3.1 0.3 -1.0 0.5 0.2 1.8 -0.2 -0.2 -0.1
Allergy 1.7 3.9 18.2 1.2 0.2 -0.8 4.3 0.9 -2.7 -0.9 -1.2
Pain all over the body in last month 0.9 1.0 2.5 -1.6 -0.7 0.7 -0.6 1.2 1.5 -0.2 0.3
Diabetes (self-reported) 1.5 2.2 5.9 -2.0 -1.6 1.8 -2.4 -0.1 1.0 -1.0 -0.2
Hayfever/allergic rhinitis (self-reported) 2.5 3.3 10.5 -2.3 -2.0 1.9 -3.2 -0.6 0.9 -0.9 -0.8
Medication: Ramipril 0.9 1.2 3.0 -1.3 -1.7 1.2 -1.0 0.0 0.3 -1.4 -0.3
Medication: Simvastatin 0.1 0.1 0.3 0.5 0.0 0.0 -0.3 -0.5 -0.5 0.4 0.2
Fluid intelligence score 0.4 0.9 2.8 -0.6 -0.5 1.0 -0.2 0.8 -0.9 -1.7 -1.0
Illnesses of siblings 0.9 1.2 2.3 -0.1 1.5 -0.9 -1.0 -1.0 1.3 1.4 0.9
Neuroticism score 0.2 0.5 1.2 -0.4 -1.1 0.4 -1.0 0.3 0.1 -0.8 -0.7
Weight 0.3 1.5 4.5 -0.6 -0.8 -0.6 0.2 -1.1 1.6 1.4 2.1
Impedance of arm (right) 0.1 0.3 1.0 0.5 1.0 -0.1 -0.8 -0.0 -0.2 -0.1 -0.3
Arm fat percentage (right) 0.5 1.9 5.0 -1.6 -1.3 0.7 -0.9 -1.6 2.2 0.6 1.1
Trunk fat-free mass 0.1 0.5 1.9 0.2 -0.3 -0.8 0.6 -0.4 0.3 0.9 1.4
Hip circumference 0.2 0.8 2.7 -0.6 -1.6 0.1 1.0 0.1 0.8 0.4 1.3
Time employed in main current job 0.6 0.7 1.9 0.8 -0.1 -0.8 0.2 -1.4 -0.3 1.1 1.1
Alcohol intake versus 10 years previously 0.4 0.6 2.1 -1.4 -0.2 0.8 -0.7 -0.3 0.5 -0.0 0.9
Father’s age at death 0.4 0.5 2.5 -0.6 -0.0 0.8 -0.6 -1.6 0.2 -0.6 -0.3
Worrier / anxious feelings 0.3 0.5 1.4 -0.5 1.1 0.2 -1.0 -0.5 1.2 -0.1 -0.2
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.7 5.1 -0.9 1.0 -0.7 -0.5 -1.0 2.3 1.4 1.8
Falls in the last year 2.4 3.3 9.3 -3.0 -1.2 2.6 -0.4 -0.5 2.5 -0.7 -1.3
Hair/balding pattern: Pattern 3 0.3 0.4 0.9 0.8 -0.7 -0.6 0.2 0.4 -0.9 0.2 0.5
Number of live births 0.5 0.7 2.0 -0.4 -1.4 1.1 -0.6 0.6 -0.5 -0.9 -0.6
Forced expiratory volume in 1-second (FEV1) 0.1 0.5 1.7 -0.2 0.3 0.4 0.2 1.0 -0.2 -1.3 -0.9
Pulse rate 0.2 0.4 1.7 -1.3 0.2 0.5 0.7 0.2 0.4 -0.3 -0.1
Happiness 0.4 0.5 1.9 -0.0 0.5 -0.8 -0.1 -0.1 0.6 0.8 1.4
Noisy workplace 1.0 1.2 2.8 1.4 1.5 -1.7 0.0 -0.3 -0.3 1.2 1.0
Qualifications: A levels/AS levels or equivalent 0.1 0.2 1.3 -0.1 -0.1 0.1 -1.2 -0.4 -0.0 -0.2 0.1
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.4 3.9 -1.3 -0.6 1.4 -2.0 -0.4 0.3 -1.2 -1.3
Mouth/teeth dental problems: Dentures 0.1 0.2 0.6 0.1 0.2 0.3 -0.7 -0.1 0.8 0.4 -0.2
Asthma 1.7 3.4 9.8 -1.4 0.2 0.6 -2.9 -1.7 3.1 1.5 1.3
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 1.6 0.1 -0.5 0.2 0.1 1.3 0.3 -0.9 -0.7
Medication: Cholesterol lowering 0.4 0.7 2.4 -1.2 -1.6 1.3 0.1 0.1 0.2 -0.4 0.1
Depression (self-reported) 2.0 2.4 6.2 -1.9 -0.5 0.9 -0.9 -2.5 2.3 0.9 1.2
Medication: Lansoprazole 0.6 0.7 2.5 -0.9 -1.6 0.7 -0.5 1.0 0.2 -0.4 -0.5
Prospective memory result 2.1 2.6 5.2 1.4 0.9 -2.3 2.1 -0.0 -0.1 2.1 2.0
Lung cancer (father) 0.4 0.5 1.1 -0.9 0.4 0.7 0.4 -1.0 1.0 0.5 -0.1
Illnesses of mother 2.0 2.4 5.4 1.6 1.9 -1.7 1.1 -1.7 0.6 2.3 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.5 1.6 -0.4 0.3 0.5 -0.1 0.5 -0.0 -1.2 -1.3
Pulse wave Arterial Stiffness index 0.5 0.6 1.5 1.0 0.8 -0.8 0.3 1.2 0.1 0.4 0.8
Impedance of arm (left) 0.1 0.3 1.3 0.7 1.1 -0.4 -0.5 -0.3 0.2 0.3 0.1
Arm fat mass (right) 0.3 1.2 3.1 -1.2 -1.4 0.3 -0.4 -1.1 1.8 0.5 1.1
Trunk predicted mass 0.1 0.4 1.7 0.2 -0.3 -0.7 0.6 -0.3 0.2 0.8 1.3
Standing height 0.3 3.0 6.3 2.1 1.2 -2.4 1.1 -0.3 -0.1 2.1 2.5
Length of working week for main job 0.2 0.2 0.6 -0.0 -0.2 0.1 0.7 0.8 0.3 0.4 0.5
Exposure to tobacco smoke at home 0.8 0.9 2.1 -0.9 -1.4 1.2 -0.6 0.7 -0.1 -1.3 -0.9
Breastfed as a baby 0.7 0.8 1.9 1.1 -0.9 -0.7 0.4 1.0 -1.0 0.2 1.4
Tense / ‘highly strung’ 1.1 1.9 4.6 -1.9 -1.6 1.6 -2.1 -0.2 0.9 -1.0 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 2.0 3.1 7.6 -2.3 -0.9 1.4 -2.8 -1.8 2.4 0.2 0.6
Hair/balding pattern: Pattern 4 0.8 2.0 5.7 -0.6 -1.0 1.1 -2.4 0.9 -0.9 -1.6 -1.9
Birth weight of first child 4.2 7.6 18.3 0.0 4.3 -1.7 -1.2 -2.6 3.4 3.1 3.3
Peak expiratory flow (PEF) 0.5 1.1 3.4 -1.2 -0.5 1.1 0.1 1.1 0.3 -1.8 -1.2
Pulse wave reflection index 0.4 0.5 1.7 1.3 0.7 -0.5 -0.0 1.2 -0.5 -0.3 0.2
Ever highly irritable/argumentative for 2 days 1.2 1.4 3.9 -0.6 0.8 -0.3 0.5 -1.3 2.0 1.5 1.5
Loud music exposure frequency 0.4 0.4 1.1 -1.0 -0.1 0.8 0.8 -0.3 0.2 -0.2 -1.1
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.5 0.3 -0.7 0.0 -0.7 0.4 -0.5 -0.4 0.2
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 2.1 1.1 0.2 -1.0 -0.6 -0.3 -0.7 1.5 1.1
Blood clot in the leg (DVT) 0.3 0.3 1.3 0.0 0.7 0.2 0.2 -0.1 1.1 0.3 0.8
Medication: Paracetamol 0.4 0.7 3.4 0.3 -0.3 -0.1 -0.7 1.8 -0.4 -0.9 -0.8
Headache pain in last month 0.4 0.7 1.8 -1.2 -0.1 0.8 -1.3 -0.5 1.3 -0.0 -0.0
Medication for cholesterol, blood pressure or diabetes 1.0 1.7 6.1 1.0 2.5 -1.1 0.5 -1.8 0.2 1.4 0.0
Glaucoma (self-reported) 0.9 1.1 2.8 0.1 -1.7 0.1 -1.1 1.4 -1.1 -1.0 -0.5
Gout (self-reported) 0.8 1.0 2.5 1.5 0.7 -1.2 0.1 -1.6 -0.6 1.0 0.5
Hypothyroidism/myxoedema (self-reported) 1.2 2.3 5.7 -0.6 -0.6 1.3 -0.6 2.4 -1.2 -2.4 -1.8
Medication: Amlodipine 1.6 2.2 4.3 -0.9 -1.8 1.4 0.0 1.7 -1.1 -2.1 -1.8
Medication: Ventolin 100micrograms inhaler 1.7 2.2 7.9 -1.1 1.9 0.4 -1.0 -0.9 2.8 1.3 1.1
Birth weight 1.8 3.9 9.4 0.6 2.4 -1.5 -0.6 -3.1 1.8 2.3 2.1
Chronic bronchitis/emphysema (mother) 0.7 0.8 1.7 -1.3 0.1 1.1 -0.8 -0.1 1.3 -0.8 -0.6
High blood pressure (siblings) 1.3 1.9 5.4 0.7 -2.3 0.1 1.8 1.5 -1.9 -0.9 -0.1
Forced vital capacity (FVC), Best measure 0.1 0.2 0.6 -0.5 -0.1 0.4 -0.4 -0.0 0.1 -0.6 -0.8
Body fat percentage 0.3 1.2 3.3 -0.9 -1.3 0.0 -0.3 -0.8 1.8 0.8 1.7
Leg fat percentage (right) 0.3 1.1 3.1 -1.3 -1.8 0.6 -0.7 -0.2 1.4 0.2 1.2
Arm fat-free mass (right) 0.2 0.8 3.0 0.1 -0.6 -0.8 1.0 -0.2 0.6 1.0 1.7
Exposure to tobacco smoke outside home 0.6 0.7 2.9 -0.2 -1.7 0.3 -1.0 0.3 -0.7 -1.1 -0.4
Comparative body size at age 10 0.3 0.9 3.3 -0.5 -1.6 0.5 0.0 -0.1 -0.6 -0.6 -1.8
Number of full brothers 0.7 0.8 3.2 -0.4 -1.6 0.1 -1.8 -0.2 0.3 -0.1 0.8
Worry too long after embarrassment 0.2 0.3 1.1 0.2 0.7 -0.2 0.4 -0.6 0.3 1.0 0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.7 2.2 4.5 -1.1 0.2 0.0 -1.7 -2.1 1.9 1.3 1.8
Wheeze or whistling in the chest in last year 1.4 2.4 5.1 -2.2 -1.0 2.0 -2.1 -0.1 2.2 -0.3 -0.3
Number of children fathered 0.9 1.1 3.5 -1.0 -1.0 1.9 -0.1 -0.1 0.8 -0.9 -1.2
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 2.8 1.0 -0.3 -0.4 0.3 1.5 -1.7 -1.0 -0.1
Age at first live birth 1.7 3.1 7.1 2.7 2.2 -2.1 1.2 1.1 -2.4 -0.1 -0.1
Pulse wave peak to peak time 0.4 0.4 1.8 -0.8 -0.7 0.5 -0.1 -1.3 -0.0 -0.2 -0.6
Health satisfaction 0.3 0.4 0.9 0.0 -0.5 -0.6 -0.8 -0.9 0.2 0.6 0.8
Shortness of breath walking on level ground 0.6 0.7 1.4 1.0 0.2 -1.2 0.9 1.0 -1.1 -0.0 0.2
Qualifications: College or University degree 0.2 0.6 3.3 -0.4 0.5 0.6 -0.7 -1.8 0.7 -0.0 -0.2
Eye problems/disorders: None of the above 0.4 0.5 2.1 0.0 1.4 -0.0 -0.4 -1.2 0.4 0.3 0.0
Mouth/teeth dental problems: Loose teeth 0.7 0.8 4.5 -0.4 -0.2 0.6 -2.1 -1.3 -0.1 0.0 -0.1
Emphysema/chronic bronchitis 0.8 0.9 2.1 -1.1 1.5 0.9 0.0 -0.9 1.4 0.1 -0.5
Medication for pain relief, constipation, heartburn 1.5 2.6 7.0 1.5 2.6 -1.5 2.0 -1.8 -0.8 1.2 0.0
Neck or shoulder pain in last month 1.2 1.7 7.4 -1.1 -2.7 1.0 0.0 1.1 -0.0 -1.0 -1.3
Medication: Blood pressure 1.0 1.8 5.7 -0.6 -2.4 0.7 0.3 2.2 -0.5 -1.6 -0.2
Angina (self-reported) 1.2 1.5 3.8 -0.1 -1.9 0.6 -0.8 1.7 -1.4 -1.5 -0.7
Migraine (self-reported) 0.3 0.3 0.7 -0.6 -0.9 0.6 -0.2 -0.4 0.3 0.6 0.6
Medication: Ibuprofen 0.5 0.6 1.8 -0.7 -0.9 0.8 -0.3 0.7 1.4 -0.8 -0.4
Medication: Allopurinol 0.4 0.6 3.3 0.1 0.4 -0.1 -0.4 -1.8 0.6 0.8 0.3
Medication: Omeprazole 2.6 3.1 9.6 -2.5 -3.1 2.1 -0.0 1.1 1.4 -1.3 -0.2
Medication: Seretide 50 evohaler 1.2 1.4 4.5 -0.9 1.4 -0.2 -1.1 -1.1 2.1 0.9 1.0
Mean time to correctly identify matches 0.4 0.8 1.5 -0.0 0.8 -0.3 -0.9 -1.0 0.7 1.2 1.2
Heart disease (mother) 0.4 0.5 1.4 -0.7 -1.2 0.6 -0.7 0.6 0.3 -0.4 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 2.7 -0.0 -1.3 0.7 -1.7 0.2 -0.2 -0.5 -0.3
Whole body fat mass 0.3 1.3 3.7 -0.8 -1.1 -0.2 0.1 -0.8 1.9 0.9 1.8
Leg fat mass (right) 0.3 1.1 2.9 -0.9 -1.2 -0.0 -0.2 -0.6 1.7 0.8 1.7
Arm predicted mass (right) 0.2 1.0 3.4 0.2 -0.2 -1.0 1.2 -0.2 0.6 1.1 1.9
Pulse rate, automated reading 0.1 0.2 0.4 0.3 -0.0 -0.6 0.4 -0.1 -0.6 0.5 0.6
Alcohol intake frequency. 0.6 1.4 5.5 -2.0 0.6 0.8 -0.8 -0.3 2.4 0.3 0.2
Comparative height size at age 10 0.2 1.4 2.9 1.1 0.6 -1.7 1.7 -0.5 -0.1 1.2 1.4
Number of full sisters 0.3 0.4 2.0 0.2 -1.4 0.1 0.1 -0.2 0.5 0.7 0.3
Suffer from ‘nerves’ 1.9 3.0 6.2 -0.7 -2.4 1.6 -1.0 1.5 -0.9 -2.5 -2.2
Overall health rating 1.6 3.3 9.3 -3.0 -1.9 1.8 -2.4 -0.8 1.8 0.1 0.6
Chest pain or discomfort 0.8 1.2 2.5 -1.2 -1.4 1.4 -1.6 0.4 0.5 -1.0 -0.8
Had major operations 0.3 0.4 1.4 -1.2 -0.3 0.9 -0.2 -0.4 0.8 -0.2 0.1
Age at last live birth 0.2 0.3 0.9 0.0 0.5 0.0 -0.9 0.7 -0.3 -0.9 -0.3
Family relationship satisfaction 0.7 0.9 3.2 0.1 -0.4 -0.2 -0.6 -1.8 0.3 1.1 1.4
Leg pain on walking 0.5 0.7 1.4 0.4 1.2 -1.1 0.2 0.9 0.8 0.6 0.8
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 2.5 -0.8 1.5 0.6 -0.1 -0.6 1.6 1.0 0.1
Commuting to job workplace: Car/motor vehicle 0.7 0.8 2.1 1.1 0.4 -0.9 0.0 -1.4 -0.5 0.9 0.8
Illness, injury, bereavement, stress in last 2 years 1.1 1.4 2.8 1.5 -0.1 -1.7 1.1 -0.9 -0.4 1.5 1.3
Medication: Aspirin 2.4 3.2 11.9 -1.5 -3.4 2.1 -1.3 1.7 -0.3 -1.5 0.1
Supplements: Vitamin C 1.5 1.8 3.7 -1.6 -1.3 1.7 -1.9 0.8 0.7 -1.1 -1.2
Knee pain experienced in last month 0.4 0.7 2.0 -0.4 -0.6 -0.2 -0.0 -1.4 0.9 0.9 1.0
Hypertension (Self-reported) 0.6 1.5 5.5 0.2 -2.3 -0.1 -0.1 2.2 -1.2 -0.6 0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.5 1.8 5.4 -1.0 -2.3 1.3 0.7 0.9 -0.3 -2.0 -0.9
Illnesses of father: Heart disease 0.9 1.3 4.9 -0.6 -0.7 1.1 -1.0 2.2 -0.2 -1.4 -0.5
Illnesses of siblings: Diabetes 5.0 6.2 14.0 -3.6 -2.0 3.7 -1.7 -0.5 1.0 -2.9 -2.5
Smoking status: Previous 0.1 0.2 1.1 -0.0 0.1 0.3 -0.2 -1.1 0.2 0.1 0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 2.0 -1.1 0.3 0.3 0.1 0.7 1.4 -0.3 0.4
Whole body fat-free mass 0.1 0.7 2.3 -0.3 -0.3 -0.6 0.4 -0.8 0.9 1.1 1.5
Leg fat-free mass (right) 0.3 1.7 4.2 -0.9 0.1 -0.4 0.1 -1.8 2.1 1.4 1.7
Arm fat percentage (left) 0.4 1.7 5.3 -1.6 -1.3 0.7 -0.8 -1.4 2.3 0.5 1.0
Average weekly red wine intake 0.6 0.9 3.7 -0.9 -0.1 0.3 -1.9 -1.2 1.0 0.5 0.3
Handedness (chirality/laterality): Left-handed 2.0 2.3 5.4 -1.8 -0.9 1.9 -0.7 0.6 0.4 -2.2 -2.3
Mood swings 0.4 0.7 1.5 -0.5 -1.2 1.1 -1.1 -0.2 0.5 -0.6 -0.8
Loneliness, isolation 0.9 1.2 4.3 -1.2 -0.1 -0.1 -1.3 -0.8 2.1 0.6 1.1
Long-standing illness, disability or infirmity 0.9 1.3 3.5 -1.2 -1.9 0.9 -1.9 0.2 0.6 -0.6 0.5
Ever had bowel cancer screening 0.8 1.0 3.0 -0.7 -1.7 1.4 -1.0 -0.5 -0.5 -0.9 -0.1
Diabetes diagnosed by doctor 2.4 4.0 9.4 -2.3 -2.9 2.3 -3.1 0.7 0.6 -1.7 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 1.6 1.7 3.3 -1.7 -1.0 1.8 -1.4 -0.6 0.7 -1.1 -1.6
Friendships satisfaction 2.4 3.0 8.0 0.2 1.1 -1.6 0.7 -1.6 1.6 2.6 2.8
Qualifications: nursing, teaching 0.2 0.4 1.2 -0.4 0.2 0.3 0.6 1.1 -0.0 -1.0 -0.5
Commuting to job workplace: Walk 1.3 1.4 5.9 -1.4 0.3 0.4 -0.0 -0.7 2.4 1.2 1.1
Eye problems/disorders: Cataract 0.4 0.4 1.6 0.1 0.3 -0.3 0.8 0.2 0.6 0.8 1.3
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 5.7 -1.3 -0.7 1.6 -2.4 -0.7 1.1 -0.5 -0.2
Medication for cholesterol 0.2 0.3 1.3 -0.2 0.2 0.2 0.2 -0.2 0.5 -1.1 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.7 -0.5 0.1 0.1 0.4 -0.8 0.2 0.4 -0.5
Back pain experienced in last month 0.4 0.6 1.3 -1.1 -0.7 1.1 -0.3 0.2 0.9 -0.7 0.1
Mineral and other dietary supplements 2.4 3.2 9.6 1.6 3.1 -2.4 -0.3 -1.2 0.2 1.9 1.6
Breast cancer (self-reported) 0.7 0.8 1.8 0.1 1.3 -0.7 -1.0 -1.3 0.3 1.1 -0.2
Asthma (self-reported) 1.6 3.1 8.8 -1.3 0.0 0.7 -3.0 -1.8 2.8 1.3 1.0
Osteoporosis (self-reported) 4.5 5.6 16.2 -0.0 1.2 -1.3 -0.1 -2.4 2.8 3.3 4.0
Osteoarthritis (self-reported) 0.5 0.7 3.0 -0.8 -1.7 0.9 0.6 0.6 0.3 -0.6 -0.5
Medication: Aspirin 2.2 2.9 10.8 -1.5 -3.3 2.0 -1.1 1.3 -0.3 -1.6 -0.1
Medication: Gliclazide 2.8 3.1 7.0 -2.4 -1.9 2.2 -2.6 0.4 1.1 -1.3 -0.9
Illnesses of father: None of the above (group 1) 3.2 3.9 7.9 2.2 1.6 -2.8 1.6 -2.3 -1.0 2.3 1.5
Smoking status: Current 0.5 0.8 2.4 -0.8 -1.5 0.3 -1.3 -0.2 0.1 0.6 0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 1.9 -0.4 0.5 0.1 -0.2 -1.4 0.6 0.3 0.6
Whole body water mass 0.2 0.9 2.7 -0.3 -0.2 -0.6 0.3 -1.0 1.1 1.2 1.7
Leg predicted mass (right) 0.3 1.7 4.3 -0.9 0.2 -0.4 0.1 -1.8 2.1 1.4 1.6
Arm fat mass (left) 0.3 1.3 3.6 -1.1 -1.3 0.1 -0.3 -1.2 1.9 0.7 1.4
Number of self-reported non-cancer illnesses 1.8 3.2 8.8 -2.6 -1.8 1.4 -1.6 0.1 3.0 0.2 1.5
Average weekly champagne plus white wine intake 0.2 0.3 0.5 0.3 0.5 -0.5 0.5 -0.7 0.5 0.7 0.6
Miserableness 0.5 0.9 1.9 -1.4 -0.6 1.1 -0.5 0.2 0.9 -1.2 -1.0
Guilty feelings 0.2 0.3 1.1 -0.2 -0.7 0.3 -1.0 -0.3 0.3 -0.1 -0.6
Wears glasses or contact lenses 0.4 0.5 1.8 -0.5 -0.2 0.5 -0.4 -1.4 1.0 0.3 0.4
Ever taken oral contraceptive pill 1.5 1.6 4.9 -0.2 0.9 -0.7 -0.3 -2.2 0.6 1.8 1.7
Hearing aid user 2.3 2.6 4.9 1.9 1.7 -2.2 2.1 1.3 -0.6 0.9 1.5
Mother’s age at death 3.1 3.9 9.1 -2.1 -1.1 2.7 -1.2 0.9 0.6 -3.0 -2.5
Financial situation satisfaction 0.4 0.4 1.3 -0.4 -0.2 -0.4 0.4 0.1 1.1 0.7 1.1
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.4 0.6 0.4 -0.8 -0.9 0.5 -0.5 0.0 1.2
Commuting to job workplace: Public transport 1.7 2.0 4.8 -2.2 -1.2 2.1 -0.6 -1.0 1.8 -0.8 -0.5
Eye problems/disorders: Glaucoma 1.1 1.3 4.0 -0.3 -2.0 0.4 -0.9 1.8 -0.7 -1.1 -0.6
Medication: Blood pressure 0.5 0.9 2.4 1.1 -0.7 -0.6 1.4 0.5 -1.6 0.5 0.5
Pain type(s) experienced in last month: Hip pain 0.6 0.7 1.6 -0.8 -0.9 0.3 -1.0 -1.3 0.6 0.8 0.6
Supplements: Fish oil (including cod liver oil) 1.4 1.8 5.7 -1.4 -2.4 1.8 -0.0 1.1 -0.2 -1.1 -1.1
High cholesterol (Self-reported) 0.4 0.7 2.5 -0.2 0.6 0.2 1.6 -1.2 0.4 0.6 0.6
Medication: Bendroflumethiazide 1.1 1.6 8.1 -0.1 -0.7 -0.5 2.8 2.0 -0.1 -0.1 0.3
Medication: Paracetamol 0.2 0.3 1.5 0.3 -0.1 -0.4 -0.6 1.2 0.1 -0.3 -0.2
Medication: Lisinopril 0.5 0.7 1.8 -0.1 1.2 -0.2 -0.3 -0.5 1.3 0.8 1.0
Medication: Atorvastatin 0.5 0.6 3.1 -0.3 -0.1 0.3 1.8 1.2 -0.3 -0.4 0.1
Illnesses of father: High blood pressure 4.1 5.1 9.5 -0.7 -3.1 2.0 -0.8 2.5 -2.0 -2.9 -2.7
Alcohol drinker status: Never 1.6 1.9 7.1 -1.7 0.4 0.8 -1.4 -1.2 2.7 0.9 0.5
Ever smoked 0.5 0.9 2.4 1.5 -0.2 -1.2 -0.6 0.6 -1.5 0.2 0.7
Basal metabolic rate 0.2 0.9 3.2 -0.2 -0.3 -0.8 0.4 -0.9 1.1 1.2 1.8
Leg fat percentage (left) 0.3 1.2 2.7 -1.4 -1.5 0.6 -0.8 -0.3 1.6 0.3 1.2
Arm fat-free mass (left) 0.1 0.6 2.6 0.2 -0.5 -0.8 0.6 -0.1 0.3 0.8 1.6
Number of operations (self-reported) 0.9 1.4 4.2 -2.0 -1.0 1.2 -0.3 -0.4 1.8 -0.0 0.9
Average weekly beer plus cider intake 0.2 0.3 0.6 0.8 0.0 -0.7 0.5 -0.2 -0.5 0.6 0.3
Irritability 0.1 0.2 1.1 0.3 -1.0 -0.1 0.3 -0.3 -0.0 0.2 -0.1
Risk taking 0.7 1.0 2.0 0.4 1.4 -0.7 -0.7 -1.2 1.0 1.1 1.2
Ever had prostate specific antigen (PSA) test 0.4 0.5 2.6 0.4 -0.9 -0.1 1.6 0.3 -0.1 0.3 0.5
Fractured/broken bones in last 5 years 1.4 1.8 3.8 -1.5 -0.6 1.1 -0.7 -1.9 1.6 1.3 1.1
Age started oral contraceptive pill 1.1 1.4 3.5 1.9 0.2 -1.1 1.0 -0.1 -1.5 0.8 1.5
Diastolic blood pressure, automated reading 2.4 7.5 17.2 1.4 -3.6 0.0 1.1 4.0 -4.2 -3.0 -1.5
Ever depressed for a whole week 0.2 0.3 1.1 -1.1 -0.5 0.4 0.4 0.3 0.6 0.1 0.3
Unable to work because of sickness or disability 3.1 4.0 10.1 -3.2 -2.2 2.6 -1.4 -1.0 2.2 -1.1 -1.0
Commuting to job workplace: Cycle 0.3 0.3 1.0 0.4 1.0 -0.4 -1.0 -0.1 0.1 0.4 0.3
Myopia 1.2 1.7 3.1 1.8 1.6 -1.6 0.2 -0.8 -1.1 1.3 1.2
Vascular/heart problems diagnosed by doctor 0.8 2.3 8.4 -0.5 2.4 0.0 0.2 -2.9 1.7 0.8 -0.3
Cholesterol lowering medication 0.3 0.4 0.9 -0.5 0.9 0.6 0.3 -0.6 1.0 0.5 -0.0
Medication: Omeprazole (e.g. Zanprol) 2.2 2.7 8.2 -2.4 -2.9 2.0 -0.3 0.4 1.5 -0.8 0.2
Pain experienced in last month 2.4 4.0 10.0 3.2 3.1 -2.4 0.1 -0.6 -2.2 1.2 0.8
Supplements: Calcium 0.4 0.5 1.7 -0.6 -0.3 1.1 1.3 -0.1 0.7 -0.2 -0.2
Basal cell carcinoma (self-reported) 0.8 0.9 1.9 -1.1 -0.6 1.4 -0.2 0.7 -0.0 -1.2 -1.4
Heart attack/myocardial infarction (self-reported) 0.5 0.6 3.1 -0.0 -0.8 0.7 0.2 1.8 0.0 -0.5 -0.3
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.7 0.0 0.7 0.2 0.1 -0.3 1.3 0.4 0.8
Heart disease (siblings) 0.8 1.0 2.8 1.2 -1.3 -0.0 0.6 1.7 -1.2 -0.6 -0.0
Alcohol drinker status: Previous 0.3 0.4 1.5 0.3 1.2 -0.6 -0.8 -0.4 0.3 0.3 -0.2
Pack years of smoking 0.6 0.9 4.2 -0.7 0.6 0.2 -0.3 -0.1 2.0 0.9 1.0
Impedance of whole body 0.2 0.9 2.8 1.4 0.8 -0.7 0.1 1.7 -1.1 -0.4 -0.3
Leg fat mass (left) 0.3 1.2 3.3 -1.0 -1.0 -0.1 -0.2 -0.7 1.8 0.9 1.7
Arm predicted mass (left) 0.1 0.5 2.2 -0.2 -0.7 -0.6 0.7 -0.2 0.6 0.7 1.5