Best TWAS P=1.04e-10 · Best GWAS P=4.51e-13 conditioned to 1.23e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RRP1B | 0.11 | 0.09 | lasso | 11 | 0.11 | 3.7e-13 | -4.37 | -5.6 | 2.0e-08 | -0.07 | 0.46 | 0.54 | FALSE |
| 2 | GTEx | Artery Aorta | PDXK | 0.14 | 0.11 | lasso | 3 | 0.12 | 6.2e-07 | -6.25 | -6.1 | 1.4e-09 | -0.04 | 0.47 | 0.53 | FALSE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | HSF2BP | 0.30 | 0.27 | lasso | 3 | 0.30 | 1.4e-10 | -5.61 | -5.5 | 2.9e-08 | -0.03 | 0.69 | 0.31 | FALSE |
| 4 | GTEx | Esophagus Mucosa | RRP1B | 0.14 | 0.10 | enet | 13 | 0.11 | 8.0e-08 | -6.14 | -6.0 | 2.2e-09 | -0.02 | 0.47 | 0.53 | FALSE |
| 5 | GTEx | Esophagus Mucosa | PDXK | 0.29 | 0.18 | enet | 12 | 0.24 | 4.1e-16 | -6.11 | -6.5 | 1.0e-10 | -0.02 | 0.54 | 0.46 | TRUE |
| 6 | GTEx | Lung | PDXK | 0.14 | 0.04 | lasso | 5 | 0.04 | 2.3e-04 | -6.25 | -5.5 | 3.0e-08 | -0.05 | 0.32 | 0.46 | FALSE |
| 7 | GTEx | Muscle Skeletal | HSF2BP | 0.10 | 0.04 | lasso | 7 | 0.04 | 1.5e-04 | -5.61 | -6.1 | 1.3e-09 | -0.04 | 0.61 | 0.38 | FALSE |
| 8 | GTEx | Muscle Skeletal | PDXK | 0.06 | 0.02 | lasso | 3 | 0.01 | 8.3e-02 | -5.72 | -5.6 | 2.3e-08 | -0.03 | 0.25 | 0.26 | FALSE |
| 9 | GTEx | Testis | HSF2BP | 0.22 | 0.27 | lasso | 3 | 0.27 | 2.8e-12 | -5.66 | -5.9 | 4.0e-09 | -0.04 | 0.66 | 0.34 | FALSE |
| 10 | GTEx | Testis | RRP1B | 0.13 | 0.10 | enet | 12 | 0.11 | 2.0e-05 | -5.73 | -5.2 | 1.9e-07 | 0.01 | 0.37 | 0.29 | FALSE |
| 11 | GTEx | Vagina | PDXK | 0.23 | 0.19 | lasso | 1 | 0.23 | 5.2e-06 | -5.79 | -5.8 | 7.0e-09 | -0.04 | 0.41 | 0.39 | FALSE |
| 12 | GTEx | Whole Blood | RRP1B | 0.06 | 0.02 | lasso | 3 | 0.00 | 1.3e-01 | -5.64 | -5.6 | 2.5e-08 | -0.05 | 0.18 | 0.12 | FALSE |
| 13 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RRP1B | 0.04 | 0.01 | lasso | 4 | 0.03 | 7.1e-03 | -5.73 | 6.0 | 1.6e-09 | 0.03 | 0.02 | 0.75 | FALSE |
| 14 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | HSF2BP | 0.16 | -0.01 | blup | 62 | 0.02 | 4.7e-02 | 0.99 | 5.8 | 5.1e-09 | 0.06 | 0.01 | 0.20 | FALSE |
| 15 | The Cancer Genome Atlas | Stomach Adenocarcinoma | RRP1B | 0.05 | 0.06 | lasso | 2 | 0.05 | 2.4e-04 | -5.73 | 5.8 | 7.7e-09 | 0.02 | 0.04 | 0.94 | FALSE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | HSF2BP | 0.04 | 0.02 | lasso | 3 | 0.02 | 1.1e-02 | -5.66 | -6.3 | 3.4e-10 | -0.05 | 0.04 | 0.51 | FALSE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | RRP1B | 0.05 | 0.00 | blup | 49 | 0.01 | 3.9e-02 | 0.11 | -5.7 | 1.4e-08 | -0.09 | 0.01 | 0.33 | FALSE |