Best TWAS P=1.91e-14 · Best GWAS P=6.21e-17 conditioned to 5.96e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LOC100505876 | 0.09 | 0.02 | enet | 7 | 0.04 | 3.6e-06 | -8.4 | -5.7 | 1.0e-08 | 0.88 | 0.00 | 1.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | PRKD3 | 0.08 | 0.04 | lasso | 3 | 0.04 | 3.0e-05 | 7.3 | 7.7 | 1.9e-14 | -0.47 | 0.42 | 0.41 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | AC006369.2 | 0.09 | 0.01 | enet | 12 | 0.00 | 3.2e-01 | 3.0 | -5.9 | 4.7e-09 | 0.14 | 0.09 | 0.05 | FALSE |
| 4 | GTEx | Lung | QPCT | 0.15 | 0.01 | lasso | 7 | 0.00 | 2.8e-01 | 4.6 | 5.9 | 3.7e-09 | -0.27 | 0.08 | 0.12 | FALSE |
| 5 | NTR | Blood | PRKD3 | 0.04 | 0.02 | lasso | 3 | 0.02 | 3.9e-08 | 5.3 | 5.6 | 1.7e-08 | -0.25 | 0.87 | 0.13 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | PRKD3 | 0.09 | 0.08 | lasso | 2 | 0.07 | 6.4e-09 | 7.5 | 7.5 | 7.1e-14 | -0.36 | 0.59 | 0.41 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PRKD3 | 0.05 | 0.02 | lasso | 3 | 0.05 | 2.3e-06 | 7.3 | 6.8 | 8.3e-12 | -0.54 | 0.33 | 0.41 | FALSE |