Best TWAS P=9.94e-14 · Best GWAS P=7.76e-15 conditioned to 0.000202
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Putamen basal ganglia | HAAO | 0.18 | 0.28 | lasso | 2 | 0.25 | 1.2e-06 | 4.86 | -5.4 | 7.2e-08 | 0.03 | 0.21 | 0.19 | FALSE |
| 2 | GTEx | Colon Sigmoid | HAAO | 0.19 | 0.02 | enet | 23 | 0.06 | 4.5e-03 | -4.97 | -6.3 | 2.9e-10 | 0.03 | 0.26 | 0.04 | TRUE |
| 3 | GTEx | Nerve Tibial | OXER1 | 0.31 | 0.03 | lasso | 8 | 0.05 | 3.5e-04 | 5.28 | -5.4 | 7.2e-08 | -0.02 | 0.26 | 0.67 | FALSE |
| 4 | GTEx | Spleen | FTOP1 | 0.27 | -0.01 | lasso | 13 | 0.01 | 2.2e-01 | 4.23 | 7.4 | 9.9e-14 | -0.01 | 0.09 | 0.11 | TRUE |
| 5 | GTEx | Stomach | AC010883.5 | 0.16 | 0.07 | lasso | 6 | 0.07 | 2.4e-04 | 5.57 | -5.3 | 9.1e-08 | 0.45 | 0.28 | 0.17 | TRUE |
| 6 | GTEx | Vagina | ZFP36L2 | 0.32 | 0.08 | enet | 27 | 0.14 | 4.7e-04 | -7.21 | 5.5 | 4.7e-08 | -0.44 | 0.05 | 0.39 | FALSE |
| 7 | NTR | Blood | COX7A2L | 0.02 | 0.00 | blup | 513 | 0.01 | 5.2e-03 | -2.02 | 5.8 | 7.5e-09 | 0.01 | 0.06 | 0.02 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | KCNG3 | 0.08 | 0.01 | bslmm | 506 | 0.02 | 4.6e-04 | -0.94 | -5.3 | 1.3e-07 | -0.02 | 0.12 | 0.08 | TRUE |
| 9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | HAAO | 0.04 | 0.05 | lasso | 4 | 0.05 | 2.7e-06 | 4.65 | -5.1 | 3.1e-07 | 0.01 | 0.09 | 0.90 | FALSE |
| 10 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PLEKHH2 | 0.07 | 0.00 | blup | 127 | 0.03 | 3.2e-04 | -3.31 | -6.6 | 3.8e-11 | 0.35 | 0.12 | 0.13 | TRUE |
| 11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PLEKHH2 | 0.09 | 0.01 | blup | 127 | 0.05 | 1.1e-05 | 1.75 | -5.4 | 7.0e-08 | 0.08 | 0.05 | 0.21 | FALSE |