Best TWAS P=4.75e-09 · Best GWAS P=2.72e-47 conditioned to 3.99e-38
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CGREF1 | 0.16 | 0.00 | bslmm | 320 | 0.02 | 4.2e-03 | -3.5 | 5.9 | 4.8e-09 | 0.19 | 0.04 | 0.08 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | SLC4A1AP | 0.09 | 0.07 | lasso | 7 | 0.06 | 7.2e-08 | 5.6 | -5.5 | 4.1e-08 | -0.05 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | AC074117.10 | 0.21 | 0.19 | enet | 23 | 0.18 | 1.6e-13 | -3.8 | 5.2 | 2.3e-07 | -0.01 | 0.97 | 0.02 | FALSE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | RP11-373D23.3 | 0.17 | 0.01 | enet | 15 | 0.04 | 1.2e-02 | -5.3 | 5.7 | 1.0e-08 | 0.00 | 0.03 | 0.66 | TRUE |
| 5 | GTEx | Muscle Skeletal | SLC4A1AP | 0.04 | 0.02 | lasso | 4 | 0.01 | 1.5e-02 | 4.6 | -5.5 | 3.9e-08 | -0.09 | 0.04 | 0.78 | FALSE |
| 6 | GTEx | Nerve Tibial | AC074117.10 | 0.04 | 0.05 | lasso | 2 | 0.04 | 7.7e-04 | -4.4 | 5.2 | 2.1e-07 | 0.00 | 0.07 | 0.78 | FALSE |
| 7 | GTEx | Pituitary | AC074117.10 | 0.23 | 0.23 | lasso | 8 | 0.29 | 5.6e-08 | -4.5 | 5.2 | 1.8e-07 | -0.01 | 0.18 | 0.77 | FALSE |
| 8 | GTEx | Prostate | AC074117.10 | 0.14 | 0.01 | lasso | 5 | 0.02 | 8.8e-02 | -3.8 | 5.2 | 2.3e-07 | -0.01 | 0.07 | 0.53 | FALSE |
| 9 | GTEx | Spleen | FNDC4 | 0.41 | 0.27 | lasso | 7 | 0.24 | 1.0e-06 | 5.4 | -5.3 | 1.2e-07 | -0.02 | 0.06 | 0.94 | FALSE |
| 10 | GTEx | Spleen | IFT172 | 0.17 | 0.13 | lasso | 3 | 0.07 | 7.8e-03 | 5.8 | -5.8 | 7.2e-09 | -0.04 | 0.02 | 0.84 | TRUE |
| 11 | GTEx | Vagina | AC074117.10 | 0.14 | 0.04 | enet | 13 | 0.06 | 1.4e-02 | -4.5 | 5.3 | 1.1e-07 | 0.01 | 0.13 | 0.28 | FALSE |
| 12 | NTR | Blood | CGREF1 | 0.01 | 0.00 | blup | 307 | 0.01 | 5.7e-03 | -4.9 | -5.4 | 8.4e-08 | -0.15 | 0.21 | 0.02 | TRUE |
| 13 | YFS | Blood | GPN1 | 0.04 | 0.04 | lasso | 2 | 0.03 | 2.7e-11 | 5.6 | -5.5 | 3.4e-08 | -0.04 | 0.02 | 0.98 | FALSE |
| 14 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | C2orf16 | 0.05 | 0.03 | lasso | 2 | 0.03 | 2.2e-03 | 5.5 | 5.5 | 5.0e-08 | 0.04 | 0.01 | 0.84 | FALSE |
| 15 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SLC4A1AP | 0.02 | 0.03 | lasso | 2 | 0.03 | 3.7e-04 | 4.9 | -5.1 | 3.1e-07 | -0.03 | 0.02 | 0.58 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SUPT7L | 0.05 | 0.05 | enet | 3 | 0.04 | 2.4e-03 | 5.6 | 5.6 | 1.7e-08 | 0.04 | 0.01 | 0.92 | FALSE |
| 17 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | SLC4A1AP | 0.17 | 0.05 | blup | 26 | 0.08 | 4.4e-03 | 4.0 | -5.2 | 1.9e-07 | -0.03 | 0.01 | 0.44 | FALSE |