Hub : Genes

QPCT

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1860	0.0400	2.8e-11	0.125	0.119	0.138	0.125	0.121	5.6e-15	2.6e-14	1.8e-16	5.6e-15	1.6e-14
2	GTEx	Brain Hippocampus	0.3647	0.0999	3.0e-04	0.111	NA	0.179	NA	0.049	1.5e-03	NA	5.5e-05	NA	2.8e-02
3	GTEx	Cells Transformed fibroblasts	0.1870	0.0420	3.8e-08	0.045	NA	0.055	NA	0.070	2.7e-04	NA	5.5e-05	NA	5.7e-06
4	GTEx	Lung	0.1456	0.0513	9.7e-04	0.007	NA	-0.003	NA	0.001	8.9e-02	NA	7.2e-01	NA	2.8e-01
5	METSIM	Adipose	0.0495	0.0213	3.2e-03	0.008	0.024	0.029	0.031	0.024	1.6e-02	1.3e-04	3.1e-05	1.8e-05	1.3e-04
6	ROSMAP	Brain Pre-frontal Cortex	0.1169	0.0261	2.2e-10	0.056	0.080	0.099	0.102	0.090	8.8e-08	1.9e-10	1.1e-12	4.8e-13	1.2e-11
7	YFS	Blood	0.0325	0.0119	8.7e-04	0.008	0.002	0.018	0.009	0.018	1.1e-03	7.6e-02	8.0e-07	3.5e-04	1.2e-06
8	TCGA	Bladder Urothelial Carcinoma	0.0440	0.0220	3.6e-03	-0.003	0.025	0.027	NA	0.012	7.2e-01	2.9e-03	2.3e-03	NA	3.2e-02
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0415	0.0196	2.1e-03	0.023	0.014	0.015	NA	0.016	1.2e-03	9.9e-03	7.0e-03	NA	6.0e-03
10	TCGA	Brain Lower Grade Glioma	0.0763	0.0299	1.2e-05	0.020	0.050	0.044	NA	0.050	1.9e-03	2.0e-06	9.2e-06	NA	2.0e-06
11	TCGA	Stomach Adenocarcinoma	0.0670	0.0360	5.0e-03	-0.004	0.036	0.024	NA	0.001	9.8e-01	1.3e-03	7.3e-03	NA	2.8e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.9	1.5	2.4	1.0	1.6	1.5	1.1	1.1	1.5	-1.1	1.2	0.9	1.4	-0.5
Bipolar Disorder or Schizophrenia	4.0	9.8	18.1	3.1	4.2	3.9	2.6	2.5	3.9	-1.1	4.1	2.7	3.1	-1.4
Depressed Affect (Nagel 2018)	0.3	0.7	1.7	-1.3	-0.1	-0.7	-0.3	-0.3	-1.3	-1.0	-0.6	-1.3	-0.3	0.9
Depression (Nagel 2018)	0.4	0.6	2.2	-1.5	0.4	-1.0	-0.5	-0.3	-0.8	0.3	0.0	-0.9	-0.6	0.9
Intelligence (Savage-Jansen 2018)	0.3	0.9	5.9	-0.7	-0.1	0.1	-2.4	0.3	-0.0	-0.6	0.7	-1.4	-0.5	0.6
Neuroticism (Nagel 2018)	0.1	0.2	0.7	-0.4	0.8	-0.5	0.1	0.3	-0.4	0.1	0.0	-0.6	-0.0	0.1
Schizophrenia (2018)	4.6	9.5	19.0	3.2	4.2	3.7	2.5	2.3	3.7	-0.5	4.4	2.7	2.9	-1.4
Schizophrenia vs Biploar Disorder	1.1	1.5	3.2	0.9	1.6	1.0	-0.5	1.6	1.8	1.6	1.4	-0.3	1.1	0.6
Worry (Nagel 2018)	0.5	1.1	3.3	0.5	1.3	0.0	-0.1	1.8	1.1	-0.3	0.9	0.4	1.3	-1.6
Alzheimer’s Disease (in mother)	4.1	4.8	11.1	-3.3	-0.2	-3.1	-2.9	-0.2	-1.0	-0.4	-0.9	-3.1	-1.3	3.3
Alzheimer’s Disease (in father)	2.4	2.6	6.0	-2.4	-0.0	-0.7	-2.2	-1.3	-1.1	-2.4	-1.8	-2.4	-0.4	-0.3
Alzheimer’s Disease (including proxy)	6.6	9.5	24.0	-4.9	-0.6	-3.5	-3.9	-1.6	-2.5	-2.9	-2.0	-4.5	-1.9	2.8
Crohns Disease (2017)	0.5	1.0	4.1	1.3	0.4	2.0	1.3	-0.2	1.2	-0.1	1.0	1.2	0.3	-0.0
Irritable Bowel Disease (IBD)	1.6	3.9	9.9	2.2	0.8	3.1	2.4	1.7	2.5	0.1	2.2	1.8	1.9	-0.8
Ulcerative Colitis (UC)	2.3	4.3	7.9	2.0	0.5	2.5	2.3	2.8	2.8	0.5	1.8	1.7	2.7	-1.3
Major Depression (MDD)	0.6	0.7	2.0	0.6	1.0	0.9	0.9	0.5	1.1	1.4	-0.1	0.8	0.9	-0.0
Reaction Time	0.1	0.3	1.0	0.3	0.5	1.0	0.4	0.0	0.8	-0.0	0.4	0.2	-0.5	0.7
Verbal and Numeric Reasoning (VNR)	0.8	2.0	6.7	-1.8	-1.6	-1.6	-2.6	-0.5	-1.0	-0.2	-0.6	-2.0	-1.0	0.6
Breast Cancer	0.4	0.9	5.0	0.6	0.6	0.3	2.2	-1.1	-0.6	1.1	-0.7	1.0	-0.3	0.5
Ovarian Cancer	1.2	1.6	5.4	-1.3	-0.8	-2.1	-2.3	0.5	-0.9	0.2	-0.2	-1.7	-0.7	0.7
Prostate Cancer	0.7	1.0	5.6	-0.6	1.0	-0.0	-2.4	0.4	0.3	-0.8	-0.1	-1.4	-0.9	0.2
Age at First Birth	1.4	2.0	4.9	0.5	1.9	0.6	1.1	1.5	1.5	2.2	1.9	1.2	0.8	0.9
Bipolar Disorder (2011)	2.8	2.7	5.3	2.1	0.7	2.0	1.4	1.8	2.0	-0.2	0.0	2.2	2.3	-1.2
Body Mass Index (BMI) (2010)	0.6	0.8	3.2	-1.0	-0.9	-0.1	-1.2	1.8	0.4	0.5	0.6	-0.7	0.7	0.3
Coronary Artery Disease (CAD)	0.4	0.5	1.9	0.9	0.3	0.5	0.7	0.6	-0.3	0.1	-0.2	0.9	1.0	-1.4
Crohns Disease (2012)	0.6	1.0	2.9	1.1	0.3	1.7	1.1	0.3	1.3	0.5	0.4	0.9	1.2	-1.1
Mean Putamen Volume	0.2	0.2	1.0	-0.5	0.1	-0.6	-0.1	0.1	0.2	0.7	0.4	-0.2	1.0	-0.2
Fasting Glucose	0.5	0.6	1.5	-0.6	-0.4	0.9	0.4	-1.0	-1.1	0.5	-0.8	-1.2	-0.3	-0.4
HbA1C	1.0	1.1	4.7	-0.1	-0.7	-1.0	1.5	-2.2	-1.3	-0.1	-0.3	1.0	-0.8	-0.3
HDL Cholesterol	0.7	1.2	3.2	1.1	1.6	0.8	1.8	-0.5	0.6	0.5	1.2	1.6	-0.4	0.1
LDL Cholesterol	0.7	1.1	2.9	-1.4	-1.3	-0.7	-0.3	-0.7	-1.1	-0.2	-0.8	-1.2	-1.2	1.7
Lupus	0.4	0.6	1.9	-0.3	-1.0	0.2	-1.4	0.8	-0.0	-0.6	-0.6	-1.3	0.1	0.4
Neuroticism (2016)	0.5	0.8	3.7	-0.9	0.6	-0.5	0.4	-0.9	-1.2	0.2	-1.9	-1.0	-0.3	0.3
Primary Biliary Cirrhosis	0.4	0.6	1.9	-0.3	-0.2	0.4	-0.2	1.4	0.7	1.2	-0.9	-0.6	0.8	-0.5
Rheumatoid Arthritis	1.4	1.9	4.5	-1.9	-1.2	-1.8	-1.1	-0.3	-1.1	1.1	-1.1	-1.5	-1.1	2.1
Schizophrenia (2014)	5.7	12.7	21.8	3.8	4.1	4.3	2.9	3.3	4.6	0.1	4.7	3.0	4.2	-1.1
Triglycerides	0.4	0.6	3.7	-0.7	-1.9	-0.1	-0.7	0.7	0.1	-0.1	0.0	-0.6	1.2	0.2
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.9	-0.8	-0.7	-0.4	-1.4	0.8	-0.2	-0.5	0.4	-0.8	-0.6	0.4
Ulcerative Colitis	4.3	6.2	11.2	3.1	0.6	2.6	2.6	3.3	2.9	0.9	3.1	2.2	2.6	-1.8
Blood Eosinophil Count	1.0	7.6	24.1	2.3	1.3	2.2	1.9	2.3	3.7	-1.5	2.4	2.1	3.4	-4.9
Blood Platelet Count	1.0	11.9	28.4	1.9	1.8	5.1	0.8	3.7	4.4	-1.5	3.5	1.9	5.3	-4.3
Blood Red Count	0.6	5.5	13.8	0.7	3.1	3.7	0.2	2.1	3.3	-2.6	1.8	-0.4	3.1	-1.2
Blood White Count	0.7	5.0	9.9	1.6	-2.1	2.7	2.1	2.0	2.1	-1.1	2.6	2.3	2.2	-3.1
Heel T-Score	1.5	12.3	20.5	3.6	2.0	3.6	2.2	4.2	4.0	-0.9	4.5	2.9	4.0	-4.5
BMI	0.3	2.0	7.1	-1.9	-1.4	-0.2	-2.7	0.8	0.9	0.8	-0.4	-2.4	0.4	1.1
Height	0.4	8.5	41.7	2.5	2.6	2.4	3.6	0.7	1.1	-1.5	-0.4	3.1	2.5	-6.5
Waist Hip Ratio (WHR)	0.3	1.5	5.2	-0.8	-1.4	-1.0	-0.8	-0.6	-1.3	-2.1	-0.1	-1.2	0.1	2.3
Systolic Blood Pressure	2.2	11.1	34.7	4.0	-1.6	3.0	5.9	-3.4	-2.3	1.6	-2.2	4.2	-0.3	-4.2
Smoking Status	0.7	1.7	5.1	-2.3	-1.2	0.2	-1.2	-1.2	-0.6	-1.3	-1.0	-2.0	-0.7	1.2
Allergy or Eczema	0.5	1.4	6.6	1.0	0.4	0.7	-0.4	1.3	1.4	-0.6	1.1	1.3	0.2	-2.6
Cardiovascular Disease	0.8	2.6	8.5	1.2	-1.0	1.4	2.9	-1.9	-1.4	1.2	-0.9	2.1	0.0	-1.7
Hypothyroidism (self reported)	0.5	1.1	3.4	-0.4	0.1	-0.2	-1.8	1.0	0.9	-1.1	-0.1	-0.7	1.3	-1.9
Respiratory disease	0.3	0.6	2.7	-1.0	-1.6	-0.1	0.1	1.1	-0.0	-0.7	0.1	-1.0	0.2	-0.1
Type 2 Diabetes (T2D) (2018)	0.4	0.7	3.5	0.1	-1.9	0.6	-0.1	-0.0	-0.0	0.1	1.3	1.1	-0.5	-0.9
Lung FEV1/FVC ratio	0.4	2.2	4.8	-2.2	-0.9	-1.8	-2.0	-0.5	-1.5	1.0	-1.2	-1.5	-1.6	1.3
Lung FVC	0.2	1.2	4.2	-0.6	1.4	0.2	-2.0	-0.6	1.0	-0.2	1.1	-1.1	-0.5	1.7
Neuroticism	0.2	0.4	1.0	-0.7	0.9	-0.6	-0.3	1.0	-0.6	0.0	-0.6	-0.9	0.1	-0.1
Chronotype (morning person)	0.2	0.6	3.7	0.4	-0.4	0.0	-0.1	1.9	0.2	0.9	-0.2	-0.1	-0.1	-1.1
Hair Pigment	0.1	2.2	7.6	-1.5	-2.4	-0.9	-0.8	-1.3	-1.3	2.8	-1.1	-0.8	-0.8	1.0
Tanning	0.3	4.0	10.0	3.2	1.9	2.4	2.8	0.2	2.4	0.1	1.8	2.4	1.2	-0.9
Hand grip strength (left)	0.4	1.0	2.2	-1.1	-0.0	-0.2	-0.0	-1.4	-1.1	-1.3	-1.5	-1.1	-1.1	-0.4
Number of treatments/medications taken	0.6	1.0	2.7	1.3	-1.5	0.7	1.4	-0.4	0.2	0.8	0.7	1.6	0.0	-0.9
Average weekly spirits intake	0.7	0.9	2.6	0.5	0.6	1.0	-0.1	0.8	0.9	-1.2	1.2	-0.1	0.8	-1.6
Sensitivity / hurt feelings	0.7	1.2	3.8	-1.2	-0.4	-0.8	-0.3	-0.1	-1.2	0.4	-1.8	-1.3	-1.9	0.6
Frequency of depressed mood in last 2 weeks	1.2	1.6	5.3	-2.3	0.3	-1.4	-1.2	-0.4	-1.6	-0.9	-1.2	-2.0	-0.9	0.3
Hearing difficulty/problems: Yes	1.1	1.6	4.0	-1.1	-0.2	-0.9	-1.9	0.0	-1.1	1.5	-1.4	-2.0	-1.7	0.7
Relative age of first facial hair	0.5	1.1	4.1	1.4	0.1	2.0	0.9	0.6	1.0	1.0	0.9	1.2	0.9	0.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.8	-0.4	0.1	0.5	0.1	0.6	0.9	-0.5	0.8	-0.2	0.3	0.4
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.1	-0.6	-1.4	-0.7	0.1	-1.1	-1.0	-0.7	0.1	0.5	-0.9	-0.4
Ever had hysterectomy (womb removed)	1.1	1.2	2.9	-1.4	-0.5	-1.2	-0.6	-1.7	-1.4	-1.2	-0.9	-0.8	-1.0	-0.4
Systolic blood pressure, automated reading	1.9	5.6	15.8	2.8	-2.0	0.2	4.0	-2.6	-2.2	2.2	-1.9	2.6	-1.4	-2.2
Eye problems/disorders: Diabetes related eye disease	5.9	6.4	9.6	-3.1	-1.9	-2.7	-3.1	-1.9	-3.0	-0.5	-2.5	-3.0	-2.3	2.6
Angina	1.3	1.7	7.9	1.3	1.1	1.5	0.9	-0.2	1.3	0.0	-0.1	1.1	1.3	-2.8
Medication for hormone replacement therapy	2.5	2.8	7.3	1.9	-0.6	1.8	2.5	-1.3	0.4	-1.0	1.7	2.7	0.8	-1.9
Vitamin and mineral supplements	0.3	0.4	1.3	-0.2	0.9	0.3	-0.6	0.6	0.8	1.1	-0.7	-0.6	0.4	0.1
Supplements: Zinc	0.7	0.7	2.8	1.1	0.9	0.6	-0.4	0.5	1.4	1.7	-0.0	0.0	0.1	-0.7
Medication: Co-codamol	0.5	0.6	2.2	0.5	-1.1	0.4	-0.2	0.3	0.7	0.5	-1.1	0.3	0.3	-1.5
Medication: Metformin	0.2	0.3	0.8	0.3	0.4	0.5	0.1	0.7	0.3	0.8	0.9	0.5	-0.1	-0.2
Diabetes (father)	0.3	0.4	0.8	-0.4	0.2	-0.8	-0.6	-0.9	-0.6	0.8	-0.1	-0.2	-0.5	0.8
Diabetes (mother)	0.6	0.8	2.9	0.1	1.5	0.8	0.9	-0.5	0.8	-0.9	-0.1	0.3	0.3	-1.7
Severe depression (siblings)	0.2	0.2	1.2	0.2	0.1	0.7	-0.1	-0.4	0.4	-0.4	0.3	0.4	0.1	-1.1
Pack years adult smoking proportion	0.2	0.3	1.5	-0.3	0.6	-1.2	0.1	0.2	0.4	0.3	0.0	0.6	-0.5	0.5
Impedance of leg (right)	0.8	3.7	14.8	2.5	-0.2	1.7	3.9	0.4	0.7	-0.6	0.8	3.1	1.6	-1.5
Leg fat-free mass (left)	0.2	0.9	2.6	-1.1	1.1	0.5	-1.6	0.6	0.6	0.2	-0.3	-1.5	0.6	-1.1
Trunk fat percentage	0.1	0.4	1.4	0.4	-0.1	0.7	0.6	1.2	0.9	0.7	0.1	-0.1	0.8	-0.5
Hand grip strength (right)	0.5	1.4	3.2	-1.8	-0.2	-0.5	-0.6	-1.2	-1.6	-1.6	-1.1	-1.8	-1.1	-0.1
Townsend deprivation index at recruitment	0.7	1.0	2.9	-1.7	-1.3	-1.1	-0.4	-0.9	-1.1	0.0	-0.6	-0.7	-0.2	1.5
Current tobacco smoking	1.3	2.2	6.6	-2.6	-0.8	-1.5	-1.3	-1.8	-1.2	-1.1	-1.8	-1.3	-1.3	0.7
Average weekly fortified wine intake	0.7	0.8	2.7	-0.4	-0.8	-0.7	-0.4	-0.6	-1.0	-1.6	-0.6	-0.4	-1.1	-1.4
Maternal smoking around birth	0.5	0.7	2.3	0.0	0.0	1.0	-0.4	1.0	1.4	1.5	0.5	-0.2	0.7	0.6
Fed-up feelings	0.8	1.5	6.3	-1.7	-0.2	0.0	-0.1	-0.5	-1.6	-2.5	-1.4	-1.3	0.1	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	2.2	2.9	7.0	-2.6	-1.1	-1.5	-1.3	-1.6	-2.5	-1.1	-1.4	-1.9	-1.9	1.0
Relative age voice broke	0.8	1.2	3.1	0.7	0.9	0.4	0.6	1.8	1.0	0.9	1.4	0.7	1.1	1.7
Taking other prescription medications	0.1	0.1	0.7	-0.1	-0.8	-0.2	0.0	-0.1	-0.0	-0.1	0.3	0.0	-0.5	0.4
Age when periods started (menarche)	0.3	0.6	3.1	0.7	0.5	-0.3	0.2	0.4	0.8	0.3	-0.1	0.9	1.8	-1.0
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.0	-0.8	0.1	-0.7	-0.3	-1.1	-1.4	-0.8	-1.1	0.0	-0.9	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	5.8	0.4	1.5	0.4	0.4	0.1	0.7	-1.8	1.9	0.6	2.4	-2.4
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.9	-0.3	-0.1	0.7	-0.4	1.4	0.9	-1.1	0.6	-0.9	0.7	0.3
Qualifications: CSEs or equivalent	0.3	0.5	1.2	0.6	0.3	0.8	0.3	0.3	0.6	0.7	0.3	1.1	0.9	-0.9
Serious illness, injury or assault to yourself	0.7	0.9	5.1	0.1	-0.8	0.3	-0.7	0.6	0.4	-2.3	0.9	-0.7	1.2	-0.3
High blood pressure	3.6	10.0	26.8	4.3	0.5	3.3	5.2	-0.5	0.7	2.5	0.2	4.9	1.2	-4.6
Hayfever, allergic rhinitis or eczema	0.6	1.3	5.0	0.6	1.0	1.0	-0.5	1.4	1.7	-0.3	0.9	0.8	0.9	-2.2
Multivitamins +/- minerals	0.2	0.3	1.0	-0.2	-0.9	-0.7	-0.5	-0.5	-1.0	-0.6	0.4	-0.1	-0.3	-0.2
Stomach or abdominal pain in last month	1.7	2.1	4.4	-2.1	-1.4	-1.4	-1.0	0.0	-1.2	0.7	-1.7	-1.9	-1.6	1.8
Supplements: Glucosamine	0.2	0.2	0.9	0.1	-0.2	-1.0	-0.1	0.0	-0.2	0.6	0.5	-0.1	-0.3	1.0
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	5.5	-0.7	-0.6	0.1	-0.6	-2.4	-1.0	-1.0	-0.9	-0.6	-0.2	0.1
Medication: Atenolol	3.2	3.9	10.7	2.8	-0.0	1.8	3.3	-0.0	0.9	2.3	0.6	3.3	0.7	-2.0
Medication: Levothyroxine sodium	0.5	0.9	4.1	-0.3	-0.6	-0.2	-0.7	0.2	0.1	-2.0	-0.1	-0.4	0.7	-2.0
Sitting height	0.1	0.7	2.1	0.0	-1.0	-0.0	0.3	-1.2	-1.1	0.2	-0.5	0.4	-1.4	-1.2
Chronic bronchitis/emphysema (father)	0.4	0.4	1.6	-0.0	0.1	-1.3	-0.5	-0.5	-0.8	1.1	-0.6	-0.2	-0.5	0.5
High blood pressure (mother)	2.5	3.5	7.8	2.8	1.9	2.5	2.3	-0.2	0.7	-0.0	1.4	2.7	0.3	-2.4
Body mass index (BMI)	0.4	1.5	5.5	-1.4	-0.9	-0.6	-2.3	0.8	0.3	0.9	-0.5	-2.4	0.0	1.0
Impedance of leg (left)	0.6	2.7	13.0	2.1	-0.2	1.5	3.6	-0.1	0.2	-1.0	0.1	2.5	1.1	-1.0
Leg predicted mass (left)	0.2	0.9	2.5	-1.1	1.1	0.5	-1.6	0.6	0.6	0.3	-0.4	-1.5	0.6	-1.1
Trunk fat mass	0.1	0.4	1.3	-0.1	0.0	0.7	0.1	1.1	0.9	0.5	-0.2	-0.7	0.7	-0.7
Waist circumference	0.2	0.8	2.7	-0.9	-1.0	-0.4	-1.4	0.6	0.4	0.8	-0.2	-1.6	0.6	0.5
Number of incorrect matches in round	1.0	1.6	5.1	1.5	1.0	1.5	2.3	0.2	1.0	0.5	1.3	1.9	0.8	0.3
Past tobacco smoking	1.0	1.9	8.2	-1.2	0.0	-2.9	-1.2	0.5	-0.7	1.3	-2.1	-0.8	-1.5	0.1
Alcohol usually taken with meals	0.5	0.8	2.6	0.1	-0.6	-1.6	0.7	0.1	-0.5	1.3	-0.1	-0.1	-1.5	1.0
Nervous feelings	0.5	0.9	4.5	0.1	0.5	-0.4	-0.5	2.1	0.8	0.7	1.0	-0.3	0.6	-1.4
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.5	-0.6	0.5	-1.0	-0.8	1.2	-0.0	-0.5	0.2	-0.6	-0.3	0.2
Hearing difficulty/problems with background noise	0.7	1.2	4.6	-0.5	-0.5	-1.0	-1.0	0.1	-1.1	1.0	-0.8	-1.5	-2.1	1.0
Hair/balding pattern: Pattern 2	0.3	0.4	1.3	-0.1	-1.1	0.2	0.6	1.2	0.6	0.8	0.2	-0.2	-0.2	0.0
Had menopause	0.2	0.3	0.9	0.7	0.2	-0.1	0.2	-0.5	-0.3	-0.5	-0.9	-0.2	0.0	-0.9
Had other major operations	0.8	0.9	3.5	0.1	-1.1	0.1	0.0	-1.6	-0.6	-1.9	-0.7	0.1	0.4	-1.4
Forced vital capacity (FVC)	0.4	1.4	4.7	-2.0	1.0	0.2	-2.2	-1.1	-0.0	-1.2	-0.5	-1.8	-0.1	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	8.4	0.2	1.1	0.4	0.5	0.5	0.8	-2.1	1.8	0.7	2.9	-2.3
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.8	-1.2	-0.0	-1.0	0.2	-1.4	-1.6	-0.9	-1.4	-0.3	-1.7	-0.5
Qualifications: None of the above	0.5	1.0	4.4	0.7	0.2	0.7	0.7	0.9	0.8	-1.1	2.1	0.8	0.9	-1.1
Financial difficulties in last 2 years	0.8	1.0	3.9	-1.7	-2.0	-0.5	-0.7	0.3	-0.9	-0.6	-0.7	-1.3	0.2	-0.2
Mouth/teeth dental problems	0.5	0.8	4.1	-0.0	0.4	0.8	0.7	-1.2	0.1	-2.0	-0.6	0.2	0.9	-0.7
Heart attack	1.8	2.3	6.2	2.4	0.6	1.3	2.5	0.1	0.2	1.5	0.8	2.5	0.5	-1.2
Allergy	0.3	0.8	5.1	-0.0	-0.2	-0.3	0.2	-1.0	-1.1	0.4	-0.5	-0.4	-0.7	2.2
Pain all over the body in last month	1.8	1.9	4.2	0.9	1.1	1.4	0.9	1.7	2.1	0.4	1.0	1.1	1.9	-1.9
Diabetes (self-reported)	0.1	0.2	0.7	0.1	-0.3	0.3	-0.1	-0.6	-0.3	-0.5	0.4	0.6	0.1	-0.8
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	4.8	0.5	0.1	-0.3	0.7	-0.2	-0.4	2.2	-1.0	0.1	-2.2	-0.1
Medication: Ramipril	0.1	0.1	0.4	0.3	-0.3	0.2	-0.1	0.5	0.1	0.5	0.2	0.1	0.6	0.1
Medication: Simvastatin	0.3	0.5	1.6	0.3	-0.8	-0.4	1.2	-0.6	-0.7	0.3	0.4	1.2	-0.3	-0.5
Fluid intelligence score	0.5	1.1	3.3	-1.4	-1.1	-1.2	-1.8	-0.2	-0.6	-0.0	-0.4	-1.6	-0.5	0.8
Illnesses of siblings	0.8	1.2	3.3	-1.6	1.8	-0.5	-1.1	1.2	0.5	0.2	0.8	-1.3	-0.0	1.3
Neuroticism score	0.3	0.6	1.6	-1.1	1.1	-0.5	-0.2	0.9	-0.6	0.0	-1.2	-1.1	-0.1	0.0
Weight	0.2	0.9	3.2	-1.1	-0.1	0.2	-1.3	0.9	0.5	0.5	-0.9	-1.8	0.6	-0.8
Impedance of arm (right)	0.9	4.0	15.1	2.6	0.7	1.3	3.9	0.1	0.8	0.5	0.4	3.2	1.1	-2.7
Arm fat percentage (right)	0.2	0.6	1.5	-0.4	-0.5	-0.3	-0.8	1.2	0.8	1.2	-0.5	-1.2	0.5	-0.4
Trunk fat-free mass	0.2	1.1	3.3	-1.6	0.7	-0.1	-1.8	0.0	-0.1	-0.2	-1.3	-1.8	0.3	-0.9
Hip circumference	0.2	0.8	2.0	-1.1	-0.8	-0.0	-0.8	0.5	0.4	1.1	-1.4	-1.3	0.6	-0.9
Time employed in main current job	0.5	0.6	1.7	0.8	-0.2	-0.1	0.8	-1.0	-0.4	-0.7	-0.5	1.0	-1.3	0.1
Alcohol intake versus 10 years previously	0.9	1.4	3.7	0.1	0.8	1.0	-1.5	1.6	1.9	-0.8	0.5	-0.2	1.7	-1.0
Father’s age at death	1.4	1.8	5.2	-1.5	0.4	-2.3	-1.2	-1.1	-1.9	-0.7	-1.4	-1.8	-0.7	0.3
Worrier / anxious feelings	0.1	0.2	0.5	-0.4	0.5	-0.7	-0.1	0.7	0.4	0.1	-0.0	-0.5	-0.3	0.7
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	4.8	-2.1	-0.4	-1.1	-1.8	-0.6	-1.1	-2.2	-0.7	-1.9	-0.9	1.4
Falls in the last year	0.3	0.4	1.9	0.3	0.2	-0.3	0.2	-1.1	-1.0	0.1	-1.4	-0.2	-0.2	-0.7
Hair/balding pattern: Pattern 3	1.3	1.9	4.3	-1.2	-2.0	-1.3	-1.0	-1.1	-2.1	-0.1	-2.1	-1.2	-1.0	0.5
Number of live births	1.4	2.0	5.5	1.0	-1.0	-0.3	2.4	1.7	0.2	2.3	-0.4	1.5	0.5	-1.9
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	6.9	-2.5	0.4	-0.2	-2.6	-0.6	-0.4	-0.9	-0.7	-2.2	-0.3	0.3
Pulse rate	1.0	1.7	5.9	1.3	1.0	1.0	0.1	2.4	2.0	1.8	0.9	0.2	0.8	0.3
Happiness	0.3	0.3	0.9	0.4	0.6	0.9	0.7	-0.0	0.0	0.8	0.3	0.4	0.1	0.9
Noisy workplace	1.0	1.3	5.1	-1.1	-1.0	0.1	-1.2	-1.4	-1.0	-2.3	-0.4	-1.1	-0.6	-0.8
Qualifications: A levels/AS levels or equivalent	0.4	0.8	5.9	0.4	-0.3	-0.6	-0.1	-0.8	0.8	2.4	0.1	0.6	-0.2	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	3.1	-0.6	1.8	-0.3	-0.9	0.5	0.6	-0.6	0.0	-0.8	0.0	0.5
Mouth/teeth dental problems: Dentures	0.9	1.5	4.0	1.6	1.0	0.8	0.5	2.0	1.4	2.0	1.1	0.8	0.4	-1.0
Asthma	0.4	0.8	2.1	-1.1	-1.3	-0.4	-0.4	1.4	0.0	-0.1	-0.7	-1.4	0.7	-0.6
Medication: Ibuprofen (e.g. Nurofen)	2.3	2.9	7.2	-1.5	-2.7	-2.2	-1.1	-2.4	-2.2	-0.4	-1.6	-1.0	-1.2	0.1
Medication: Cholesterol lowering	0.6	0.9	4.2	0.6	-0.3	1.0	2.0	0.1	0.2	0.0	1.1	1.7	0.5	-0.3
Depression (self-reported)	0.4	0.5	2.0	-0.3	0.4	0.3	-0.1	0.9	0.4	1.3	-0.2	-0.4	0.2	1.4
Medication: Lansoprazole	0.8	0.9	5.5	-1.1	-0.1	-0.4	-1.6	0.2	-0.4	-2.3	-0.0	-0.8	-0.3	0.2
Prospective memory result	2.8	3.4	9.0	2.1	1.2	3.0	1.5	0.9	2.5	-0.9	1.6	2.3	2.2	-0.5
Lung cancer (father)	2.0	2.4	8.0	-1.9	0.7	-2.0	-2.8	1.1	-0.5	-0.5	0.8	-1.7	-1.2	1.9
Illnesses of mother	1.2	1.4	3.8	-1.5	-1.3	-2.0	-1.5	-0.1	-0.7	1.2	-0.6	-1.4	0.2	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	7.0	-2.0	0.3	-0.0	-2.6	-1.2	-0.7	-0.3	-1.0	-1.9	-0.7	0.2
Pulse wave Arterial Stiffness index	0.6	0.7	1.5	1.1	0.2	0.4	0.7	1.2	0.8	0.9	0.6	0.9	0.9	-1.2
Impedance of arm (left)	0.9	4.2	15.6	2.7	1.1	1.5	4.0	0.4	1.0	1.1	0.5	3.3	1.1	-2.4
Arm fat mass (right)	0.2	0.8	3.1	-1.1	-0.4	-0.3	-1.3	1.1	0.5	0.6	-0.6	-1.8	0.5	-0.4
Trunk predicted mass	0.2	1.1	3.4	-1.7	0.6	-0.1	-1.8	0.0	-0.0	-0.2	-1.2	-1.8	0.3	-0.9
Standing height	0.2	2.4	12.0	0.5	1.7	1.8	1.9	0.1	0.5	-0.7	-0.9	0.9	1.3	-3.5
Length of working week for main job	0.5	0.6	1.6	0.7	0.6	0.3	0.9	-0.1	0.1	-1.2	1.1	0.5	1.3	0.6
Exposure to tobacco smoke at home	1.2	1.4	2.8	1.4	1.2	1.4	1.1	0.5	1.3	0.4	0.1	1.3	1.7	-1.2
Breastfed as a baby	0.2	0.2	0.7	0.5	-0.0	0.0	0.5	0.7	0.0	-0.1	0.5	0.8	0.0	-0.8
Tense / ‘highly strung’	0.4	0.6	4.8	-0.3	2.2	-0.0	-0.1	1.1	0.3	0.6	0.4	-0.3	0.2	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	6.4	-1.8	0.9	-0.5	-1.8	0.4	-0.2	-1.6	-0.0	-2.5	-0.3	0.8
Hair/balding pattern: Pattern 4	0.5	1.1	2.6	-0.7	-1.3	-1.5	-0.6	-1.0	-1.6	-0.7	-1.1	-0.4	-1.0	-0.9
Birth weight of first child	0.3	0.6	1.7	-0.6	0.4	-0.1	-0.7	0.9	0.7	0.1	1.1	-0.8	0.4	1.3
Peak expiratory flow (PEF)	0.3	0.7	2.5	-1.6	-0.7	0.1	-0.9	-0.0	-0.3	0.4	-0.9	-1.1	0.8	-1.1
Pulse wave reflection index	0.1	0.2	0.4	0.3	-0.4	-0.0	0.2	0.6	0.1	0.4	0.5	0.1	0.7	-0.6
Ever highly irritable/argumentative for 2 days	0.8	1.0	4.6	-1.0	0.1	-0.1	-0.2	-2.1	-0.8	-1.0	-0.8	-0.5	-1.5	-0.8
Loud music exposure frequency	0.3	0.3	1.4	0.5	0.5	1.2	0.4	-0.7	0.1	-0.5	0.6	0.6	-0.1	-0.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	2.0	-0.1	0.0	-0.7	-0.3	-0.8	-0.1	1.4	-0.4	0.3	-0.5	0.1
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	3.9	-1.4	-0.7	-1.3	-2.0	0.6	-0.8	0.3	-0.9	-1.9	-0.4	1.3
Blood clot in the leg (DVT)	0.6	0.8	2.7	-0.7	-1.6	-1.0	-0.3	-1.0	-1.1	-1.3	0.0	-0.2	-1.0	0.1
Medication: Paracetamol	0.4	0.6	3.6	-0.7	0.5	-0.6	-0.7	1.9	0.8	-0.3	0.2	-0.3	-0.1	0.7
Headache pain in last month	0.6	1.0	3.4	0.6	-0.2	0.0	0.2	1.8	1.3	-0.6	0.5	1.0	1.1	-1.6
Medication for cholesterol, blood pressure or diabetes	2.6	4.3	12.6	-2.5	-0.8	-2.1	-3.6	-0.4	-1.0	-1.0	-2.2	-3.5	-1.1	1.7
Glaucoma (self-reported)	0.4	0.5	1.3	-1.1	-0.6	-0.8	-1.2	0.7	0.4	0.7	-0.5	-0.5	-0.0	-0.3
Gout (self-reported)	0.4	0.6	1.7	-0.5	-1.0	0.1	0.5	-0.4	-0.6	0.5	1.2	0.2	-1.0	1.3
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	4.0	-1.0	-0.2	-0.5	-1.8	0.9	0.6	-2.0	0.0	-1.5	0.7	-1.5
Medication: Amlodipine	1.1	1.5	6.3	1.2	0.5	1.2	2.5	-0.7	-0.7	0.5	0.4	2.1	-0.8	-1.0
Medication: Ventolin 100micrograms inhaler	0.7	0.9	3.7	-0.8	-1.9	-0.7	-0.6	-0.0	-0.2	1.5	-1.1	-1.1	-0.1	-0.1
Birth weight	0.9	2.0	7.2	-0.2	1.5	-0.4	-1.6	2.7	2.1	0.4	1.1	-0.6	1.4	-1.3
Chronic bronchitis/emphysema (mother)	0.4	0.5	3.0	-0.4	0.1	-0.1	0.5	-0.3	-0.3	-0.9	0.6	0.2	-0.6	1.7
High blood pressure (siblings)	0.7	1.0	3.2	1.1	-1.8	0.3	0.4	-1.2	-0.9	-1.0	-0.4	1.0	-0.5	-1.3
Forced vital capacity (FVC), Best measure	0.3	1.1	4.5	-1.6	1.1	0.4	-2.1	-1.1	-0.1	-0.5	-0.8	-1.4	-0.3	-0.3
Body fat percentage	0.1	0.5	1.8	0.2	-0.3	0.5	0.2	1.3	1.0	0.9	-0.1	-0.5	1.0	-0.5
Leg fat percentage (right)	0.2	0.7	2.0	0.1	-1.3	0.4	-0.4	1.4	1.2	0.6	-0.0	-0.8	0.9	-0.2
Arm fat-free mass (right)	0.1	0.8	2.9	-1.5	0.5	0.1	-1.5	-0.1	-0.2	-0.5	-0.6	-1.7	0.2	-0.1
Exposure to tobacco smoke outside home	2.0	2.6	7.1	1.6	1.9	1.5	0.8	1.5	2.0	1.8	0.0	0.8	2.7	-1.6
Comparative body size at age 10	0.2	0.7	2.1	0.6	-0.0	0.9	-0.7	1.1	1.4	-0.8	0.4	0.1	1.0	-0.8
Number of full brothers	0.8	1.0	2.3	1.3	0.4	1.3	1.2	-0.4	0.3	-0.9	0.1	1.4	1.0	-1.5
Worry too long after embarrassment	1.0	1.7	5.3	-1.1	1.4	-0.7	-1.4	1.4	0.3	1.5	-0.0	-1.9	-0.1	2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.8	-1.0	0.7	0.3	-1.5	-1.1	-0.5	-1.7	-0.1	-1.3	-1.3	1.4
Wheeze or whistling in the chest in last year	0.5	0.8	2.2	-0.5	-0.2	1.0	-0.5	1.5	1.2	-0.7	0.1	-1.0	1.1	-0.9
Number of children fathered	0.5	0.6	1.5	-0.8	0.1	-0.5	-1.1	-0.9	-0.6	-0.7	-0.6	-0.9	-1.2	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.2	0.5	0.1	1.2	1.0	-1.5	-0.6	-0.2	-0.4	0.0	-1.5	0.8
Age at first live birth	0.9	1.5	5.9	0.9	1.5	1.9	1.1	0.5	1.2	2.4	-0.5	0.9	0.4	0.5
Pulse wave peak to peak time	0.6	0.8	1.6	-1.2	-0.1	-0.3	-0.7	-1.3	-0.8	-1.0	-0.7	-0.9	-0.8	1.0
Health satisfaction	0.7	1.0	2.7	1.5	-0.1	0.8	1.6	-1.0	-0.3	-0.0	0.5	1.5	-0.6	-1.1
Shortness of breath walking on level ground	2.2	2.6	5.2	1.7	0.9	1.7	2.0	1.2	1.9	1.4	1.3	2.3	1.5	-1.4
Qualifications: College or University degree	0.1	0.3	1.0	0.4	0.3	-0.2	0.5	0.3	0.9	1.0	0.3	0.7	0.5	-0.6
Eye problems/disorders: None of the above	0.7	0.8	2.3	0.7	1.5	1.3	1.0	-0.3	0.6	-1.0	0.0	0.6	1.1	0.1
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.9	-0.1	-0.9	-0.6	-0.3	-0.4	-0.5	0.5	-0.0	-0.1	-1.0	-0.1
Emphysema/chronic bronchitis	0.6	0.7	2.6	0.4	1.0	0.7	0.2	1.6	1.1	-0.0	0.3	0.0	1.2	-0.7
Medication for pain relief, constipation, heartburn	0.3	0.4	1.3	-0.8	0.4	-0.2	-0.6	-0.6	-0.9	-0.3	-0.8	-1.1	-0.5	0.5
Neck or shoulder pain in last month	1.0	1.5	5.4	1.5	2.3	0.3	-0.2	1.2	1.6	1.1	-0.3	1.0	-0.1	-1.5
Medication: Blood pressure	2.4	4.2	11.1	2.7	0.5	1.9	3.3	0.4	1.0	0.6	1.7	3.2	1.0	-2.8
Angina (self-reported)	1.0	1.4	6.6	1.1	1.1	1.3	0.7	0.1	1.3	0.2	-0.2	0.7	1.2	-2.6
Migraine (self-reported)	2.5	3.1	7.3	1.9	0.4	2.2	0.7	2.4	2.7	0.4	2.0	1.5	1.7	-1.8
Medication: Ibuprofen	2.1	2.5	4.7	-1.9	-2.0	-2.2	-1.6	-1.8	-1.9	-0.8	-1.5	-1.6	-0.4	0.1
Medication: Allopurinol	0.7	0.9	4.6	0.6	0.0	1.2	0.8	0.5	1.0	0.5	2.1	1.0	0.4	0.5
Medication: Omeprazole	0.7	0.8	2.3	-0.5	-1.3	-1.0	-1.0	0.3	-0.5	0.9	-1.0	-0.9	-1.5	-0.0
Medication: Seretide 50 evohaler	0.5	0.6	3.7	0.3	-1.0	0.1	-0.2	0.4	0.3	-1.9	0.8	-0.3	0.8	-0.3
Mean time to correctly identify matches	0.1	0.2	0.7	0.8	0.6	0.6	0.4	-0.2	0.5	-0.0	0.1	0.4	-0.8	0.2
Heart disease (mother)	1.4	1.7	7.1	1.7	0.7	2.7	1.3	0.5	1.0	0.2	0.4	1.5	1.0	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	3.2	0.6	-0.7	0.5	1.8	1.0	-0.3	0.3	-0.0	0.9	-0.2	-0.5
Whole body fat mass	0.1	0.4	1.5	-0.2	0.0	0.6	-0.2	1.2	0.8	0.5	-0.2	-0.9	0.8	-0.7
Leg fat mass (right)	0.2	0.8	2.8	-0.2	-0.5	0.8	-0.6	1.7	1.3	0.7	0.2	-0.9	1.1	-0.6
Arm predicted mass (right)	0.2	0.9	3.2	-1.5	0.3	0.0	-1.7	-0.0	-0.3	-0.5	-1.0	-1.8	0.1	-0.2
Pulse rate, automated reading	0.2	0.8	3.8	0.6	1.1	-0.5	0.2	2.0	1.0	0.8	0.4	-0.2	1.1	-0.2
Alcohol intake frequency.	1.0	2.3	5.6	1.0	1.8	1.3	0.9	2.4	1.9	-1.3	0.8	0.7	1.6	-2.0
Comparative height size at age 10	0.2	1.2	4.3	0.2	0.3	1.0	1.6	0.7	0.0	-1.5	-0.4	0.0	1.4	-2.1
Number of full sisters	2.0	2.4	7.4	-2.4	-0.1	-2.7	-1.6	0.1	-1.6	-1.7	-0.4	-1.4	-1.5	0.9
Suffer from ‘nerves’	0.4	0.7	2.7	-0.7	-0.0	-0.3	-1.0	0.9	0.2	-1.6	-0.4	-0.9	0.7	-1.0
Overall health rating	0.2	0.4	1.8	-0.4	-0.5	0.4	0.0	0.5	0.5	-1.4	0.5	0.0	0.2	-1.1
Chest pain or discomfort	0.6	0.9	2.8	-1.6	-0.9	-0.1	-1.0	1.0	0.4	-0.6	-0.3	-1.7	0.6	0.3
Had major operations	0.3	0.4	1.0	-0.2	0.5	0.2	0.1	0.9	1.0	0.5	0.1	-0.8	0.9	0.7
Age at last live birth	1.6	2.3	6.2	1.5	1.0	1.8	2.0	1.1	1.6	2.5	0.4	1.8	1.1	-0.5
Family relationship satisfaction	0.2	0.3	1.2	0.2	0.3	0.3	0.7	-0.8	-0.3	-1.1	0.1	0.5	0.0	0.6
Leg pain on walking	2.9	3.7	7.1	2.7	0.3	1.5	2.2	2.2	2.2	2.1	1.2	2.6	0.6	-2.0
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.7	-0.8	-0.1	-0.9	-1.1	0.3	-0.9	0.7	0.2	-0.7	-1.3	0.9
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.9	0.0	0.2	0.5	0.4	0.9	0.2	0.7	-0.1	-0.1	-0.3	0.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	2.6	0.4	-0.5	-0.0	0.9	-0.7	-0.0	1.6	-0.3	0.6	-0.2	0.1
Medication: Aspirin	0.6	0.8	1.7	1.1	-0.1	0.5	0.3	0.6	1.1	1.3	1.2	1.1	1.1	-0.4
Supplements: Vitamin C	0.7	0.9	2.0	-0.6	-1.2	-1.4	0.6	-1.4	-1.0	-0.8	-0.6	0.1	-1.1	-0.4
Knee pain experienced in last month	0.4	0.7	2.8	-0.4	0.9	-1.0	-0.7	0.4	0.3	0.6	0.4	-0.4	-1.1	1.7
Hypertension (Self-reported)	3.4	9.4	28.6	4.1	0.5	2.9	5.3	-0.7	0.3	2.5	-0.1	4.8	0.9	-4.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.3	2.7	4.6	-1.7	-1.1	-2.0	-2.0	-0.5	-1.8	-0.3	-2.1	-2.1	-2.1	0.6
Illnesses of father: Heart disease	1.2	1.7	4.7	1.8	0.4	0.6	1.6	0.5	0.8	0.1	2.1	2.2	0.9	-1.0
Illnesses of siblings: Diabetes	0.3	0.3	1.5	-0.7	0.2	-0.2	-0.3	0.2	0.3	0.6	-1.2	-0.5	0.7	0.0
Smoking status: Previous	1.0	1.5	7.0	1.1	0.7	2.7	0.9	-0.4	0.6	-1.2	1.7	0.4	1.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	2.1	-1.4	0.8	0.5	-1.0	0.0	0.5	-1.4	-0.0	-0.7	0.6	-0.8
Whole body fat-free mass	0.2	1.1	3.7	-1.6	0.8	0.1	-1.9	0.2	0.1	-0.1	-1.0	-1.9	0.3	-0.7
Leg fat-free mass (right)	0.2	1.2	4.1	-1.6	1.0	0.2	-2.0	0.2	0.1	-0.0	-0.8	-2.0	0.1	-0.6
Arm fat percentage (left)	0.2	0.6	1.9	-0.2	-0.1	0.1	-0.5	1.3	1.1	1.4	-0.2	-0.9	0.7	-0.3
Average weekly red wine intake	0.9	1.4	5.3	-0.1	-2.3	-1.6	0.4	-1.0	-1.5	0.6	-1.4	-0.6	-1.2	-0.1
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.2	0.2	0.6	0.7	0.8	-0.4	0.2	-1.5	0.9	0.5	0.7	-0.9
Mood swings	0.4	0.8	1.8	-1.3	0.6	-0.4	0.4	-0.2	-1.3	-0.5	-1.0	-1.0	-0.9	1.1
Loneliness, isolation	0.7	1.0	4.8	-1.1	0.8	-0.4	0.0	-0.4	-1.1	-2.2	-0.9	-0.5	-0.8	-0.8
Long-standing illness, disability or infirmity	0.3	0.4	2.9	-0.7	0.0	-0.0	-0.4	-0.2	0.2	-1.7	0.2	-0.6	-0.2	-0.7
Ever had bowel cancer screening	0.9	1.0	2.3	-1.5	-0.8	-1.4	-1.3	1.2	-0.1	-1.0	-0.2	-1.2	0.4	-0.7
Diabetes diagnosed by doctor	0.1	0.2	0.8	-0.4	-0.9	0.1	-0.4	-0.1	-0.4	-0.1	0.4	0.2	-0.2	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.9	0.5	-0.1	-0.1	1.7	-1.5	-0.8	1.1	-0.0	1.0	-0.0	-0.1
Friendships satisfaction	0.3	0.3	1.4	-0.4	0.6	0.1	0.5	-0.7	0.2	-0.9	1.2	-0.2	-0.4	0.5
Qualifications: nursing, teaching	0.2	0.3	1.3	-0.1	-0.0	-0.1	0.1	-1.1	-0.2	0.8	0.0	-0.1	0.0	1.1
Commuting to job workplace: Walk	0.7	0.8	2.8	1.2	1.7	0.7	0.8	-0.4	0.2	-0.3	-0.6	0.4	0.2	-1.5
Eye problems/disorders: Cataract	0.4	0.5	1.4	0.6	-0.9	0.4	0.6	1.2	0.2	1.0	0.8	0.5	0.1	-0.6
Mouth/teeth dental problems: Mouth ulcers	1.0	1.5	3.5	-1.3	-1.8	-1.3	-0.5	-0.2	-1.2	0.5	-1.2	-1.0	-1.9	1.5
Medication for cholesterol	4.1	6.2	17.8	-3.5	-0.3	-2.7	-3.8	1.4	-0.5	-0.4	-1.8	-4.2	-1.4	2.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.2	-0.8	0.1	-0.8	1.1	-0.8	-0.5	-0.8	0.1	0.6	-0.2	-0.3
Back pain experienced in last month	1.0	1.5	2.8	1.4	0.7	1.4	1.7	0.9	1.1	0.7	1.5	1.6	0.5	-1.4
Mineral and other dietary supplements	0.4	0.5	1.6	0.3	1.0	0.7	0.1	-0.5	0.7	-1.3	0.5	0.5	0.8	-0.6
Breast cancer (self-reported)	0.4	0.4	1.1	0.7	0.3	1.0	0.7	0.1	0.5	-0.8	0.7	0.4	0.3	1.0
Asthma (self-reported)	0.4	0.8	3.0	-0.9	-1.0	-0.2	-0.2	1.7	0.4	-0.2	-0.4	-1.2	0.9	-0.9
Osteoporosis (self-reported)	0.4	0.5	1.7	0.2	-1.3	-1.1	-0.7	-0.4	-0.7	-0.2	0.1	0.4	-0.4	-0.8
Osteoarthritis (self-reported)	0.8	1.0	3.1	-0.6	-0.5	-1.0	-1.8	0.0	-0.5	-0.8	-0.4	-1.7	-1.4	0.4
Medication: Aspirin	0.7	0.9	1.8	1.3	0.0	0.6	0.6	0.5	1.1	0.9	1.0	1.3	1.1	-0.8
Medication: Gliclazide	0.4	0.5	2.2	-0.6	-0.4	0.3	-1.5	0.6	0.0	-0.9	0.8	-0.6	-0.0	0.3
Illnesses of father: None of the above (group 1)	0.9	1.1	3.2	-1.4	0.0	-0.6	-1.8	1.8	0.3	-0.2	-0.3	-1.7	0.3	0.5
Smoking status: Current	1.0	1.6	5.2	-2.3	-0.7	-1.1	-0.9	-1.7	-1.0	-1.1	-1.5	-1.1	-1.1	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.2	5.7	-1.8	0.6	-1.5	-2.4	-0.6	-1.0	1.2	-1.6	-2.0	-1.4	1.2
Whole body water mass	0.2	1.2	3.9	-1.6	0.9	0.0	-2.0	0.3	0.1	-0.0	-1.0	-1.9	0.4	-0.8
Leg predicted mass (right)	0.2	1.1	3.6	-1.5	1.1	0.2	-1.9	0.2	0.2	-0.0	-0.7	-1.9	0.2	-0.6
Arm fat mass (left)	0.2	0.7	2.4	-0.9	-0.2	-0.1	-1.2	1.1	0.6	0.7	-0.5	-1.6	0.4	-0.3
Number of self-reported non-cancer illnesses	0.2	0.4	1.9	0.6	0.5	0.5	0.4	0.2	0.8	1.4	0.4	0.1	0.5	-0.4
Average weekly champagne plus white wine intake	0.3	0.5	1.4	-0.3	-0.6	-0.7	0.3	-1.1	-0.7	-0.1	-1.2	-0.3	-0.1	1.0
Miserableness	0.6	1.0	2.6	-1.3	-0.7	-0.7	-0.8	0.4	-1.1	0.6	-1.1	-1.6	-0.8	1.4
Guilty feelings	0.2	0.3	1.0	-0.1	0.8	1.0	-0.1	0.1	-0.3	-0.5	-0.5	-0.6	-0.1	-0.9
Wears glasses or contact lenses	0.9	1.1	3.4	1.7	-0.2	1.1	1.0	0.7	1.2	-0.2	0.7	0.9	0.3	-1.8
Ever taken oral contraceptive pill	0.7	0.8	1.7	-1.3	-1.3	-0.7	-0.9	1.0	-0.3	-0.5	0.1	-0.9	-0.3	-1.3
Hearing aid user	0.6	0.7	1.7	-0.7	0.8	-0.9	-1.1	0.7	-0.3	-1.3	-0.4	-1.2	-0.5	-0.4
Mother’s age at death	0.4	0.5	0.9	1.0	0.9	0.2	1.0	-0.9	0.2	0.7	0.5	0.9	0.2	-0.4
Financial situation satisfaction	0.1	0.1	0.4	-0.3	0.3	0.1	0.6	-0.4	-0.5	-0.3	-0.5	-0.1	0.4	-0.2
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.5	0.6	0.1	1.2	0.2	0.6	0.5	-0.1	-0.2	0.1	1.0	-1.1
Commuting to job workplace: Public transport	1.5	1.8	6.4	1.1	-0.1	1.1	1.6	-0.3	1.2	-0.2	2.0	1.6	2.5	0.0
Eye problems/disorders: Glaucoma	0.4	0.5	1.7	-0.9	-0.6	-1.3	-0.4	0.5	0.1	1.1	-0.8	-0.1	0.0	-0.4
Medication: Blood pressure	3.9	7.5	18.3	4.0	0.3	3.1	3.9	-0.2	1.0	2.1	0.7	4.3	1.0	-4.0
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.2	0.3	1.1	0.6	-0.2	-0.4	0.4	-0.6	-0.1	-0.2	-0.5	0.9
Supplements: Fish oil (including cod liver oil)	0.5	0.7	3.0	-0.1	-1.7	-0.8	0.1	1.2	-0.2	1.4	0.1	-0.1	-0.5	0.2
High cholesterol (Self-reported)	0.2	0.4	1.1	0.3	-1.0	-0.2	1.0	-0.4	-0.8	0.1	-0.4	0.6	-0.1	-0.9
Medication: Bendroflumethiazide	2.4	3.7	10.8	2.5	0.0	2.2	3.0	0.1	0.6	0.4	1.1	3.3	0.6	-2.9
Medication: Paracetamol	0.5	0.8	4.2	-0.7	0.7	-0.3	-1.2	2.1	1.0	-0.3	0.2	-0.7	0.4	0.5
Medication: Lisinopril	1.0	1.3	6.5	0.7	-0.8	1.4	0.7	-0.0	-0.5	-1.1	-1.2	1.0	0.1	-2.5
Medication: Atorvastatin	0.2	0.2	1.5	-0.2	-0.4	0.2	0.6	-0.2	-0.3	-0.1	-0.6	0.0	-0.3	-1.2
Illnesses of father: High blood pressure	1.8	2.3	5.1	2.0	1.2	1.8	2.3	-1.6	0.4	-1.2	0.5	2.0	1.1	-1.1
Alcohol drinker status: Never	1.1	1.4	3.5	1.9	1.4	1.0	0.9	0.4	1.2	-0.7	0.9	1.3	1.1	-1.4
Ever smoked	0.5	0.9	2.5	-0.0	-1.0	1.6	0.7	-1.5	-0.6	-1.6	0.6	0.2	0.4	-0.1
Basal metabolic rate	0.2	1.1	4.0	-1.6	0.6	0.1	-1.9	0.3	0.1	-0.1	-1.1	-2.0	0.4	-0.8
Leg fat percentage (left)	0.1	0.5	1.3	-0.1	-1.1	0.2	-0.6	1.1	0.8	0.3	-0.4	-1.1	0.6	0.0
Arm fat-free mass (left)	0.3	1.4	5.0	-2.0	-0.2	-0.4	-2.0	-0.2	-0.6	-0.7	-1.2	-2.2	-0.0	-0.2
Number of operations (self-reported)	0.3	0.4	1.5	-0.3	0.2	-0.9	-0.8	0.7	0.2	-0.5	-0.8	-1.2	0.5	-0.2
Average weekly beer plus cider intake	1.5	2.1	7.4	-1.5	-1.1	-1.3	-1.2	-2.2	-2.7	-0.3	-0.4	-0.7	-1.5	1.3
Irritability	0.3	0.5	1.9	0.1	0.5	-0.2	1.3	0.1	-0.7	1.4	-0.3	0.5	-0.7	0.2
Risk taking	0.4	0.6	1.7	1.0	1.3	0.7	0.5	-0.7	0.1	-0.3	1.1	1.1	0.3	0.7
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.4	-0.9	0.1	-1.5	-0.1	-0.4	-0.9	1.1	-0.0	-0.9	-0.9	0.7
Fractured/broken bones in last 5 years	0.8	1.0	2.2	0.0	-1.5	-0.8	0.2	-1.1	-1.3	-1.3	-1.4	0.1	-1.2	-0.4
Age started oral contraceptive pill	0.7	0.8	3.6	1.4	0.3	0.0	1.4	-0.0	0.6	0.7	-0.5	0.8	0.1	-1.9
Diastolic blood pressure, automated reading	1.2	3.8	10.7	2.5	-2.4	0.0	3.3	-1.4	-1.7	1.1	-1.7	1.8	-0.8	-2.4
Ever depressed for a whole week	0.4	0.5	3.6	-0.0	1.9	0.6	0.4	-0.3	0.3	-0.7	-0.3	0.1	-0.0	-0.1
Unable to work because of sickness or disability	0.9	1.1	3.3	-0.1	1.8	1.0	-0.1	1.5	1.1	-1.7	1.0	0.0	0.7	0.3
Commuting to job workplace: Cycle	0.8	1.0	2.8	-0.7	-1.3	-1.3	-0.4	-0.7	-1.0	0.5	-1.7	-0.8	-1.2	0.5
Myopia	0.5	0.8	3.2	0.6	-0.0	1.4	-0.5	-0.0	1.0	-0.3	1.3	0.0	1.8	0.6
Vascular/heart problems diagnosed by doctor	2.9	7.8	22.4	-3.7	-0.2	-2.7	-4.7	0.9	-0.3	-2.1	0.2	-4.3	-1.2	4.2
Cholesterol lowering medication	0.5	0.7	1.7	0.8	-1.3	-0.5	1.0	-1.1	-0.7	0.5	0.9	1.2	-0.1	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.4	-0.2	-1.0	-0.6	-0.4	0.3	-0.3	-0.1	-0.5	-0.3	-1.2	-0.5
Pain experienced in last month	0.6	1.0	2.8	-1.1	-1.7	-0.6	-0.3	-1.3	-1.4	-1.0	-0.3	-0.8	0.1	1.0
Supplements: Calcium	1.1	1.2	3.5	-0.8	-1.5	-1.5	-1.4	-0.2	-0.9	0.2	-1.9	-0.7	-1.0	0.1
Basal cell carcinoma (self-reported)	1.4	1.7	6.1	-1.7	-0.4	0.1	-2.5	1.6	0.3	-0.9	-0.9	-2.3	0.2	0.3
Heart attack/myocardial infarction (self-reported)	1.7	2.2	6.6	2.4	0.4	1.2	2.4	-0.2	0.0	1.3	0.8	2.6	0.5	-1.3
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	2.3	-0.6	-1.5	-0.9	-0.2	-0.9	-0.9	-1.4	0.1	-0.1	-0.7	0.0
Heart disease (siblings)	1.2	1.4	5.0	1.6	-0.9	-0.0	1.3	-1.5	-0.1	0.0	-0.2	1.8	0.1	-2.2
Alcohol drinker status: Previous	0.5	0.5	2.1	-0.3	1.4	-0.2	-0.5	0.4	0.4	-1.2	-1.1	-0.1	-0.5	-0.3
Pack years of smoking	0.2	0.3	0.8	0.2	0.9	-0.8	0.3	0.6	0.9	0.3	0.4	0.8	-0.0	0.3
Impedance of whole body	0.8	4.1	18.5	2.6	0.4	1.5	4.3	0.1	0.5	-0.1	0.5	3.4	1.2	-1.9
Leg fat mass (left)	0.2	0.6	2.0	-0.4	-0.4	0.6	-0.8	1.4	1.0	0.4	-0.1	-1.2	0.9	-0.4
Arm predicted mass (left)	0.2	1.3	4.8	-1.8	0.1	-0.1	-2.0	0.2	-0.3	-0.7	-1.0	-2.2	0.2	-0.3