Best TWAS P=1.85e-09 · Best GWAS P=1.44e-11 conditioned to 1.05e-13
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | EFEMP1 | 0.11 | 0.00 | enet | 22 | 0.05 | 1.1e-04 | -4.7 | 5.1 | 2.8e-07 | 0.17 | 0.35 | 0.05 | FALSE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | SMEK2 | 0.07 | 0.05 | lasso | 2 | 0.04 | 6.3e-06 | -5.0 | 5.2 | 2.7e-07 | -0.03 | 0.70 | 0.07 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PNPT1 | 0.02 | 0.03 | enet | 9 | 0.03 | 1.2e-07 | -5.2 | -5.5 | 4.6e-08 | 0.10 | 0.02 | 0.98 | FALSE |
| 4 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PNPT1 | 0.11 | 0.03 | blup | 58 | 0.06 | 7.6e-04 | -5.4 | -6.0 | 1.9e-09 | 0.11 | 0.01 | 0.98 | TRUE |
| 5 | The Cancer Genome Atlas | Stomach Adenocarcinoma | PNPT1 | 0.08 | 0.08 | lasso | 3 | 0.06 | 3.9e-05 | -4.9 | -5.1 | 2.9e-07 | 0.09 | 0.03 | 0.97 | FALSE |