Hub : Genes

OXER1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.1970 0.0480 2.6e-11 0.204 NA 0.201 NA 0.245 1.9e-11 NA 2.6e-11 NA 9.8e-14
2 GTEx Artery Tibial 0.2269 0.0572 4.7e-08 0.128 NA 0.080 NA 0.101 3.0e-10 NA 7.6e-07 NA 2.6e-08
3 GTEx Brain Caudate basal ganglia 0.3490 0.1370 8.2e-03 0.004 NA 0.034 NA 0.035 2.4e-01 NA 3.8e-02 NA 3.6e-02
4 GTEx Brain Cerebellar Hemisphere 0.5180 0.1160 6.5e-04 0.101 NA 0.066 NA 0.164 1.5e-03 NA 8.9e-03 NA 5.5e-05
5 GTEx Brain Hypothalamus 0.1850 0.0750 1.2e-03 0.025 NA 0.045 NA 0.088 8.8e-02 NA 3.2e-02 NA 4.4e-03
6 GTEx Colon Transverse 0.1520 0.0570 5.6e-04 0.192 NA 0.213 NA 0.201 1.8e-09 NA 1.8e-10 NA 6.7e-10
7 GTEx Nerve Tibial 0.3149 0.0629 2.0e-07 0.028 NA 0.025 NA 0.046 4.1e-03 NA 6.6e-03 NA 3.5e-04
8 GTEx Pancreas 0.3770 0.0850 2.3e-09 0.190 NA 0.267 NA 0.295 1.8e-08 NA 1.0e-11 NA 6.1e-13
9 GTEx Whole Blood 0.1000 0.0370 9.0e-04 0.037 NA 0.024 NA 0.038 2.4e-04 NA 2.3e-03 NA 1.8e-04
10 ROSMAP Brain Pre-frontal Cortex 0.0520 0.0177 7.5e-08 0.086 0.043 0.074 0.064 0.075 3.1e-11 3.0e-06 7.5e-10 1.1e-08 6.3e-10
11 YFS Blood 0.0381 0.0120 1.6e-05 0.033 0.014 0.031 0.030 0.034 4.6e-11 1.5e-05 1.8e-10 2.5e-10 2.0e-11
12 TCGA Colon Adenocarcinoma 0.2560 0.0800 1.5e-07 0.164 0.116 0.111 NA 0.145 9.0e-10 3.3e-07 6.3e-07 NA 9.3e-09
13 TCGA Glioblastoma Multiforme 0.1650 0.0910 3.7e-03 0.065 0.105 0.136 NA 0.136 4.9e-03 4.5e-04 6.4e-05 NA 6.4e-05
14 TCGA Head and Neck Squamous Cell Carcinoma 0.0253 0.0161 7.0e-03 0.025 0.021 0.006 NA 0.014 7.5e-04 1.7e-03 5.9e-02 NA 1.0e-02
15 TCGA Brain Lower Grade Glioma 0.0465 0.0221 2.1e-05 0.035 0.034 0.034 NA 0.037 7.0e-05 7.9e-05 8.6e-05 NA 4.6e-05
16 TCGA Lung Squamous Cell Carcinoma 0.0477 0.0242 1.6e-04 0.041 0.033 0.026 NA 0.034 1.7e-05 1.1e-04 5.8e-04 NA 8.9e-05
17 TCGA Ovarian Serous Cystadenocarcinoma 0.0420 0.0250 5.2e-03 0.006 0.010 -0.003 NA 0.000 1.1e-01 6.8e-02 6.3e-01 NA 2.9e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Bipolar Disorder (2018) 0.3 0.5 1.8 0.7 -0.0 0.2 0.4 -1.1 0.3 -1.3 0.7 -1.1 -0.6 -0.2 0.0 -0.5 -0.7 -0.6 -0.9 -0.3
Bipolar Disorder or Schizophrenia 0.7 1.7 3.8 1.6 1.0 -1.0 0.3 -1.4 -0.0 -1.4 1.5 -1.4 -1.8 -0.3 0.6 -1.6 -1.7 -1.5 -1.9 -1.1
Depressed Affect (Nagel 2018) 0.5 1.1 8.0 -0.3 0.1 -0.3 -0.8 0.2 2.4 0.4 0.2 -0.1 -0.3 0.7 2.8 -1.2 -0.2 -1.0 -0.1 -1.0
Depression (Nagel 2018) 0.3 0.4 1.1 -0.7 -0.2 0.3 -0.3 0.4 0.4 -0.0 -0.8 0.9 0.8 0.7 0.9 0.5 0.9 0.3 1.0 0.0
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.3 -0.2 0.6 -0.9 -0.2 0.6 -1.1 -0.3 -0.1 1.1 -0.2 0.9 -1.0 -0.3 -0.3 0.5 0.2 -0.2
Neuroticism (Nagel 2018) 0.4 1.0 7.8 -0.8 0.0 1.0 0.3 0.9 2.0 1.1 0.0 -0.5 0.4 0.1 2.8 -0.1 0.3 -0.2 0.3 -0.3
Schizophrenia (2018) 0.7 1.5 3.2 1.6 1.3 -1.4 -0.0 -0.9 -0.2 -1.0 1.3 -0.9 -1.8 -0.2 0.7 -1.6 -1.6 -1.4 -1.7 -1.2
Schizophrenia vs Biploar Disorder 2.1 2.8 6.9 -2.2 -1.4 1.3 0.6 2.1 -2.6 0.8 -2.3 1.7 1.8 -0.5 0.0 1.9 1.6 1.8 2.0 1.6
Worry (Nagel 2018) 0.6 1.2 8.5 0.1 0.9 0.5 0.3 0.2 2.3 -0.0 1.5 -1.2 -0.3 -0.0 2.9 -0.1 -0.3 -0.7 -0.6 -0.8
Alzheimer’s Disease (in mother) 1.9 2.2 4.4 -1.4 -1.2 1.7 1.9 1.1 1.3 1.6 -1.6 1.6 1.6 -1.2 0.9 1.1 2.1 1.1 1.7 1.6
Alzheimer’s Disease (in father) 0.6 0.6 3.2 0.5 -0.3 0.5 -0.6 -0.4 -1.5 -1.8 1.1 -0.1 -0.8 0.3 -0.6 -0.6 -0.6 -0.6 -0.7 -0.4
Alzheimer’s Disease (including proxy) 0.3 0.4 1.7 -0.0 -1.1 0.0 0.4 0.0 1.3 -0.7 -0.1 0.0 -0.2 -0.8 1.3 -0.4 0.4 -0.6 -0.3 0.4
Crohns Disease (2017) 0.4 0.8 3.6 -0.5 -1.0 -1.0 -1.9 -0.1 -0.8 -1.7 -0.4 1.3 -0.2 -0.0 -1.5 0.2 -0.2 0.4 0.2 0.4
Irritable Bowel Disease (IBD) 0.3 0.7 4.5 0.2 -0.7 -1.1 -1.6 -0.7 0.5 -2.1 0.1 0.2 -0.9 -0.0 -0.3 -0.6 -0.9 -0.5 -0.7 -0.1
Ulcerative Colitis (UC) 0.1 0.3 1.4 -0.0 -0.9 0.3 -0.0 -0.4 1.2 -0.9 -0.3 -0.3 -0.4 -0.5 0.4 -0.4 -0.4 -0.4 -0.4 0.3
Major Depression (MDD) 2.8 3.4 6.2 -2.2 -2.0 1.3 0.0 2.4 -1.4 0.8 -2.0 1.8 1.9 -2.3 -0.6 2.5 2.0 1.5 2.1 2.5
Reaction Time 1.9 3.7 7.4 -2.7 -1.8 1.9 0.6 2.7 -1.5 1.7 -2.4 1.1 2.4 -0.8 -0.9 2.1 2.0 1.8 2.3 2.2
Verbal and Numeric Reasoning (VNR) 0.4 0.9 2.9 0.6 0.8 -1.7 -1.5 -0.0 -1.5 -1.4 0.4 0.8 -0.8 0.6 -1.0 -0.5 -1.1 -0.1 -0.5 -0.6
Breast Cancer 0.4 1.0 5.1 0.1 -1.3 -1.3 -1.5 -0.1 -0.9 -1.6 -0.2 -0.9 -0.2 -0.5 -2.2 -0.5 -0.3 0.9 -0.6 1.1
Ovarian Cancer 1.1 1.4 3.5 -1.4 -1.0 1.4 0.8 1.2 -1.2 1.0 -1.6 0.7 1.2 -1.0 -1.1 0.5 0.8 1.9 1.0 1.4
Prostate Cancer 4.4 6.1 18.1 2.6 1.2 -1.9 -2.6 -2.7 0.8 -4.3 2.2 -2.0 -3.1 -0.9 1.0 -3.6 -2.7 -2.5 -3.2 -1.6
Age at First Birth 0.7 1.0 4.6 1.0 0.3 -2.1 -1.7 -1.3 0.2 -1.3 0.2 -1.0 -0.9 0.2 -0.5 -0.2 -1.0 -0.8 -1.0 -0.7
Bipolar Disorder (2011) 1.9 1.9 5.7 1.9 1.6 -1.0 -0.1 -1.6 1.6 -0.7 2.4 -0.3 -1.4 1.4 0.0 -0.6 -1.3 -1.1 -1.1 -2.0
Body Mass Index (BMI) (2010) 6.0 8.3 14.9 -3.5 -1.8 2.8 2.2 3.4 -2.5 2.7 -2.9 3.4 3.4 -0.8 -1.4 3.0 3.4 3.1 3.9 2.7
Coronary Artery Disease (CAD) 0.5 0.6 1.8 -0.5 -0.2 -0.2 0.8 1.4 0.3 1.2 -0.5 1.0 0.4 -1.0 0.0 -1.1 0.6 0.4 0.7 0.4
Crohns Disease (2012) 0.1 0.2 0.6 -0.6 -0.6 -0.5 -0.6 0.3 0.3 -0.8 -0.4 0.8 -0.3 -0.3 0.0 -0.1 -0.1 -0.0 -0.0 0.3
Mean Putamen Volume 0.4 0.4 3.3 0.2 -0.4 -1.4 -1.8 -0.3 -0.7 -0.3 -0.0 0.0 -0.5 -0.6 0.1 0.6 -0.3 -0.4 -0.3 0.1
Fasting Glucose 1.7 2.1 4.5 1.7 0.9 -1.3 -1.0 -1.7 0.8 -1.6 1.3 -1.9 -1.9 -1.0 0.4 -1.5 -1.6 -1.7 -2.1 -0.9
HbA1C 0.2 0.2 1.3 -0.2 -0.1 0.1 0.1 -0.2 0.2 -0.4 -0.2 0.1 -0.4 -1.1 0.9 -0.5 -0.2 -0.4 -0.2 -0.1
HDL Cholesterol 0.4 0.7 1.8 0.8 -0.5 0.2 0.3 -0.8 0.4 -1.1 0.6 -0.3 -1.4 -0.4 1.1 -1.3 -0.7 -1.0 -1.0 -0.6
LDL Cholesterol 0.9 1.4 5.5 -1.1 -1.4 -0.0 0.1 1.0 1.1 1.2 -1.5 -0.4 1.1 -2.4 1.4 0.2 1.5 0.7 0.7 1.5
Lupus 0.4 0.6 1.4 1.0 0.8 -0.3 -0.1 -0.5 -0.5 -0.8 0.9 -1.0 -0.8 -0.2 -0.5 -0.8 -1.2 0.1 -1.2 -0.5
Neuroticism (2016) 0.2 0.2 1.0 -0.6 0.2 0.7 -0.2 0.2 0.0 0.8 -0.4 0.2 0.5 1.0 0.3 0.5 0.1 -0.1 0.6 -0.4
Primary Biliary Cirrhosis 3.2 4.6 10.3 2.2 1.9 -1.9 -0.5 -2.1 0.7 -1.9 2.4 -1.0 -3.0 0.9 0.3 -2.9 -3.2 -2.6 -2.9 -2.3
Rheumatoid Arthritis 0.5 0.7 3.5 0.6 -0.4 -0.4 -0.3 -0.2 0.8 0.1 0.2 -1.7 -0.3 -1.5 1.9 -0.7 -0.5 -0.9 -1.0 0.1
Schizophrenia (2014) 0.8 1.8 3.8 1.6 1.1 -1.6 0.1 -1.4 -0.9 -1.5 1.3 -0.9 -1.9 -0.1 0.0 -1.4 -1.8 -1.6 -1.9 -1.3
Triglycerides 2.0 3.2 6.8 -2.4 -2.4 1.4 0.1 1.6 0.2 1.8 -1.9 0.5 2.3 -1.9 0.2 1.6 2.6 1.9 2.0 2.4
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.7 -0.8 -0.8 1.0 -0.8 -0.0 -1.3 -1.1 -0.5 1.1 0.5 0.2 -1.1 0.6 0.6 0.7 0.7 0.6
Ulcerative Colitis 0.8 1.1 3.1 1.0 0.0 -0.4 -1.0 -1.3 0.6 -1.4 0.5 -0.7 -1.4 -0.5 0.0 -1.8 -1.2 -1.7 -1.3 -0.8
Blood Eosinophil Count 0.3 2.2 12.5 -0.1 -0.9 -1.1 -0.8 -0.6 -3.4 -2.6 0.4 1.0 -0.3 1.0 -3.5 0.5 -0.4 0.9 -0.1 0.4
Blood Platelet Count 0.5 6.2 20.5 -2.2 -1.6 3.0 4.5 2.2 2.8 4.5 -2.3 0.7 2.1 -1.7 2.9 1.1 2.6 0.4 2.0 1.4
Blood Red Count 0.5 5.1 10.0 -2.1 -1.4 2.2 2.6 2.4 -3.2 1.7 -2.2 2.6 2.1 -0.7 -2.6 1.8 2.1 2.7 2.8 2.0
Blood White Count 0.4 2.6 7.6 1.5 -0.5 -0.6 -0.7 -2.5 0.3 -2.3 1.1 -2.8 -2.0 -0.9 -0.1 -1.0 -2.1 -1.8 -2.5 -0.9
Heel T-Score 0.1 1.0 3.9 0.5 -0.0 -1.6 -0.4 -0.2 -1.1 -1.1 0.4 -1.0 -0.0 1.3 -2.0 1.4 -1.2 0.7 -0.3 0.1
BMI 1.4 8.4 18.2 -3.0 -0.9 2.7 1.9 3.0 -2.0 3.6 -2.5 4.3 3.6 1.2 -1.0 2.9 4.1 3.1 4.3 1.6
Height 0.4 8.2 44.0 3.0 3.9 -2.1 -2.2 -3.1 0.4 -2.8 3.6 2.2 -1.8 6.6 -1.7 -0.6 -1.7 -1.4 -0.8 -3.9
Waist Hip Ratio (WHR) 0.2 1.0 2.8 -1.7 -0.5 1.2 0.7 1.3 -0.7 0.3 -1.1 1.3 1.0 1.2 0.0 0.2 0.6 1.2 1.4 0.4
Systolic Blood Pressure 3.0 14.9 28.9 4.0 2.1 -5.0 -4.4 -3.0 2.0 -5.4 3.4 -4.1 -4.2 -2.0 3.3 -4.4 -4.0 -4.3 -4.7 -2.9
Smoking Status 0.6 1.3 3.7 1.3 0.3 -0.1 -0.2 -1.5 1.0 -0.2 1.2 -1.9 -1.3 0.9 0.5 -1.0 -1.6 -1.5 -1.7 -1.0
Allergy or Eczema 0.4 1.1 2.8 1.6 0.4 0.1 0.6 -1.4 1.4 -0.3 1.6 -1.7 -0.7 -0.2 1.2 -0.8 -0.9 -0.7 -1.2 -0.6
Cardiovascular Disease 0.3 1.1 5.7 0.8 0.1 -0.6 -1.4 -0.3 -0.7 -1.6 0.6 -2.4 -0.5 -2.0 0.2 0.1 -0.5 -0.2 -1.2 0.2
Hypothyroidism (self reported) 0.3 0.8 1.9 1.0 1.0 -0.5 -1.1 -0.9 -0.4 -1.4 0.7 0.2 -1.0 1.4 -0.7 0.3 -1.0 -0.7 -0.8 -1.1
Respiratory disease 0.6 1.3 5.6 -1.1 -2.1 0.6 -0.1 0.4 -0.3 -0.1 -1.8 -0.0 0.8 -2.4 -0.7 0.8 1.1 0.4 0.7 1.8
Type 2 Diabetes (T2D) (2018) 1.9 3.6 16.7 -1.4 -1.0 1.3 0.5 0.8 -4.1 -0.6 -1.8 3.1 1.2 0.6 -3.4 1.3 1.3 1.8 2.1 1.2
Lung FEV1/FVC ratio 6.3 32.1 54.2 6.8 3.8 -5.1 -4.1 -7.2 7.0 -5.4 7.0 -6.3 -6.2 1.6 3.4 -4.8 -6.0 -5.5 -7.4 -5.3
Lung FVC 0.1 0.7 4.8 0.9 1.5 -0.3 -0.5 -0.7 0.3 0.2 0.8 -0.1 -0.2 2.2 -0.6 0.7 -0.6 0.0 -0.4 -1.0
Neuroticism 0.4 0.9 6.2 -1.0 0.1 1.1 0.2 1.2 1.8 1.2 0.3 -0.5 0.6 0.4 2.5 -0.2 0.5 -0.1 0.4 -0.3
Chronotype (morning person) 0.9 2.0 5.5 1.4 1.6 -1.2 -1.0 -1.4 -1.0 -1.6 1.0 -0.4 -2.1 0.5 -1.1 -1.5 -2.4 -1.3 -1.7 -1.4
Hair Pigment 0.0 0.9 2.8 -0.5 -1.7 1.4 0.9 -0.4 0.5 1.1 -1.1 -0.9 0.6 -1.4 -0.6 -0.4 0.9 0.3 0.2 1.2
Tanning 0.9 10.4 21.3 4.1 2.6 -3.1 -2.0 -4.4 2.1 -4.6 3.5 -2.0 -4.1 1.3 0.4 -2.6 -4.0 -3.2 -4.1 -3.2
Hand grip strength (left) 0.7 1.9 5.3 1.2 0.4 -0.7 -0.3 -1.4 -1.1 -1.2 1.8 -1.0 -1.4 2.3 -1.8 -1.4 -1.8 -0.5 -1.7 -1.2
Number of treatments/medications taken 0.4 0.8 3.4 1.1 1.9 -0.5 -1.1 -1.0 0.6 -0.5 1.0 0.1 -0.4 1.0 0.9 -0.3 -0.6 -0.5 -0.2 -1.2
Average weekly spirits intake 3.6 4.4 7.8 2.1 0.5 -2.2 -1.9 -2.4 2.4 -2.5 2.2 -2.2 -2.4 -0.4 1.4 -2.8 -2.2 -2.4 -2.6 -1.7
Sensitivity / hurt feelings 0.3 0.5 1.7 -0.9 -0.3 1.1 0.8 1.2 -0.5 1.3 -0.7 0.1 0.9 0.5 0.2 -0.4 0.5 0.6 0.7 0.3
Frequency of depressed mood in last 2 weeks 0.5 0.8 1.9 -1.1 -0.3 0.6 0.5 1.3 0.1 0.9 -0.9 1.3 1.2 0.3 0.5 0.8 1.1 0.7 1.4 0.4
Hearing difficulty/problems: Yes 2.5 3.8 7.4 -2.4 -2.1 1.3 1.1 2.4 -0.9 2.4 -2.7 1.1 2.3 -2.0 -0.8 0.7 2.5 1.8 2.4 2.4
Relative age of first facial hair 0.6 1.2 2.9 -1.1 -1.2 1.7 1.7 1.0 -0.8 1.3 -0.6 -0.7 1.3 -0.8 0.3 1.3 0.7 1.0 0.8 1.0
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 4.5 -1.1 -0.3 1.2 1.0 0.6 -1.0 0.3 -0.8 2.1 0.5 0.8 -0.8 0.7 0.6 0.2 1.2 0.3
Ever used hormone-replacement therapy (HRT) 1.9 2.4 5.2 -1.7 -1.7 1.6 1.0 1.0 -1.3 1.3 -2.0 1.0 1.9 -0.8 -0.2 2.3 2.0 1.5 1.9 1.6
Ever had hysterectomy (womb removed) 0.9 1.1 5.2 0.5 -0.3 -1.5 -1.6 -1.0 -1.2 -2.3 -0.3 -0.0 -1.2 -0.3 -0.7 -0.4 -1.3 -0.6 -0.9 -0.1
Systolic blood pressure, automated reading 1.1 3.1 7.1 1.5 1.0 -2.5 -2.1 -1.0 0.4 -2.5 1.2 -1.5 -2.0 -1.3 1.4 -2.7 -1.9 -1.8 -2.0 -1.2
Eye problems/disorders: Diabetes related eye disease 2.2 2.4 5.0 -1.4 0.0 2.0 1.4 0.9 -1.3 1.7 -1.2 1.8 1.9 1.4 -1.4 1.5 1.8 1.8 2.2 0.7
Angina 0.6 0.7 5.0 -0.6 0.3 1.5 2.2 1.0 -0.5 1.1 -0.3 0.6 0.4 -0.3 -0.2 0.5 0.5 0.8 0.6 0.2
Medication for hormone replacement therapy 0.2 0.3 2.6 0.4 0.4 0.2 1.6 0.3 0.3 0.6 0.3 0.2 -0.3 -0.6 0.5 0.2 0.1 -0.1 -0.2 0.0
Vitamin and mineral supplements 0.4 0.5 1.9 -0.7 -0.2 0.2 1.0 1.3 -1.4 -0.2 -0.4 1.2 0.1 -0.5 -0.5 0.1 0.6 0.6 0.4 0.4
Supplements: Zinc 1.8 2.0 5.2 1.3 0.3 -1.8 -0.9 -1.2 1.7 -1.4 0.7 -1.6 -1.5 -0.4 1.5 -2.3 -1.6 -1.8 -1.7 -0.9
Medication: Co-codamol 0.4 0.4 1.6 -0.4 -0.2 0.0 -0.4 0.4 0.2 -0.0 0.0 0.4 0.9 -0.5 1.3 1.1 1.0 1.0 0.8 0.3
Medication: Metformin 2.4 3.3 6.3 -2.1 -1.7 2.1 0.6 1.3 -2.5 0.3 -2.5 2.4 1.6 -0.6 -2.3 1.5 1.7 1.7 2.2 1.8
Diabetes (father) 0.2 0.2 1.1 0.1 0.5 0.2 0.5 0.0 0.4 1.0 0.1 0.1 0.5 0.5 1.0 -0.1 0.4 -0.1 0.4 -0.6
Diabetes (mother) 0.4 0.5 2.7 0.5 -0.2 -0.3 -0.2 -0.4 0.1 -0.9 0.3 -1.6 -0.7 -1.3 0.0 -0.2 -0.6 -0.5 -1.1 0.1
Severe depression (siblings) 0.8 0.9 3.5 -0.9 -0.5 1.2 1.9 0.5 1.1 0.6 -0.9 1.1 0.7 0.2 1.6 0.3 1.2 0.2 0.9 0.2
Pack years adult smoking proportion 0.2 0.4 1.7 0.3 1.0 0.2 -0.3 0.3 -1.2 -0.3 0.1 1.3 -0.3 0.6 -0.6 -0.4 -0.1 -0.4 0.2 -0.7
Impedance of leg (right) 0.3 1.3 5.0 0.3 -0.3 0.1 -0.0 -0.2 1.8 -1.3 0.3 -1.1 -1.1 -2.2 2.2 -1.5 -0.7 -0.8 -1.2 -0.3
Leg fat-free mass (left) 0.3 1.6 9.3 0.1 1.4 0.1 0.2 -0.0 -0.7 0.6 0.4 2.2 1.1 3.0 -1.3 1.5 1.0 1.1 1.5 -0.6
Trunk fat percentage 3.2 12.7 26.7 -4.0 -0.8 4.0 3.0 4.3 -0.8 4.7 -3.1 3.6 4.9 0.6 0.4 4.1 4.3 4.3 5.2 2.4
Hand grip strength (right) 0.6 1.8 4.2 1.6 0.8 -0.5 -0.2 -1.4 -1.1 -0.9 1.9 -1.1 -1.3 2.0 -2.0 -0.9 -1.6 -0.6 -1.5 -1.2
Townsend deprivation index at recruitment 0.5 0.7 2.6 -1.0 -0.1 1.1 0.7 1.6 -0.1 0.9 -0.6 -0.4 1.3 -0.5 0.4 1.1 0.8 0.5 0.9 0.8
Current tobacco smoking 0.3 0.5 1.4 0.8 0.7 -0.2 -0.5 -0.8 -0.1 -0.7 0.4 -0.3 -0.8 1.1 0.3 -0.8 -0.8 -1.2 -0.6 -1.1
Average weekly fortified wine intake 0.2 0.3 1.2 0.3 -0.5 -0.4 0.3 -0.5 1.1 -0.4 -0.3 -0.2 -0.1 -0.4 0.6 -1.1 0.3 -0.4 -0.2 0.0
Maternal smoking around birth 0.9 1.4 8.8 0.8 -0.3 0.1 0.5 -0.8 3.0 0.2 0.3 -1.6 -0.6 -1.3 2.4 -0.7 -0.4 -0.6 -1.0 -0.4
Fed-up feelings 0.8 1.5 3.3 -1.8 -1.0 1.4 0.7 1.7 1.1 1.8 -0.9 0.7 1.3 0.0 1.8 0.3 1.4 0.3 1.5 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 2.6 -1.2 0.0 1.4 0.2 1.1 -0.1 0.6 -0.9 1.4 1.3 0.4 0.8 1.6 1.4 0.7 1.6 0.2
Relative age voice broke 0.6 0.9 1.9 1.1 1.3 -1.0 -0.5 -0.7 0.8 -1.1 1.0 -0.3 -0.8 1.0 0.9 -0.2 -1.3 -1.2 -0.8 -1.4
Taking other prescription medications 0.6 0.9 3.2 -1.1 0.5 1.1 0.8 0.9 -0.5 1.0 -0.8 1.8 1.0 0.2 1.2 0.8 0.7 0.6 1.4 0.2
Age when periods started (menarche) 1.0 2.3 6.7 1.5 2.6 -1.8 -1.1 -0.6 0.9 -0.0 1.8 0.4 -1.4 2.5 0.4 -1.3 -1.4 -1.6 -1.0 -2.4
Bilateral oophorectomy (both ovaries removed) 1.5 1.8 9.4 -1.1 -0.4 -0.3 -0.6 0.6 -3.1 -0.3 -1.4 1.9 0.4 0.9 -2.9 1.2 0.1 1.1 1.0 0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 2.9 -0.0 0.9 -0.9 -0.0 0.7 0.5 -0.3 0.2 1.7 0.1 0.7 0.3 0.7 0.0 0.1 0.7 -0.5
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.1 -0.1 0.5 0.6 0.3 0.1 -0.5 -1.1 0.7 1.1 -0.6 0.9 0.1 0.1 -0.9 -0.2 -0.2 -0.6
Qualifications: CSEs or equivalent 0.6 0.8 3.5 0.5 0.1 0.2 -0.2 -0.3 1.9 -0.1 0.7 -1.5 -0.5 -1.3 1.6 -0.5 -0.2 -0.6 -1.0 -0.2
Serious illness, injury or assault to yourself 1.3 1.5 3.0 1.6 1.7 -1.3 -1.3 -1.4 0.6 -1.0 1.3 -0.8 -1.3 -0.7 0.7 -1.6 -1.2 -1.4 -1.3 -1.0
High blood pressure 0.8 2.1 10.0 0.9 0.5 -1.7 -3.2 -0.9 -0.5 -3.1 0.4 -1.7 -1.1 -1.3 -0.1 -0.5 -1.4 -1.3 -1.4 -0.3
Hayfever, allergic rhinitis or eczema 0.3 0.7 2.2 1.1 -0.3 0.3 0.5 -1.5 1.1 -0.6 1.2 -1.4 -0.6 -0.4 0.5 -0.4 -0.6 -0.3 -1.0 -0.1
Multivitamins +/- minerals 0.9 1.1 3.5 1.4 0.3 -1.2 -1.9 -1.8 0.9 -0.9 0.7 -1.3 -0.8 0.3 -0.3 -0.2 -1.4 -0.8 -1.0 -0.4
Stomach or abdominal pain in last month 1.8 2.2 4.6 -2.1 -1.6 1.4 0.5 1.3 -2.0 1.3 -1.9 1.8 1.5 -0.7 -1.2 1.1 1.5 1.2 1.9 1.5
Supplements: Glucosamine 1.9 2.5 4.8 2.2 1.9 -0.7 -0.9 -2.0 2.1 -1.1 1.8 -1.6 -1.4 1.1 1.6 -0.4 -1.6 -1.4 -1.8 -2.1
Diverticular disease/diverticulitis (self-reported) 3.1 3.7 8.2 1.8 -0.5 -2.5 -0.9 -2.9 1.7 -1.5 1.2 -2.9 -2.0 -1.6 1.2 -2.3 -1.7 -2.3 -2.5 -0.8
Medication: Atenolol 0.7 0.8 2.0 -1.0 -1.1 0.8 0.6 0.8 -1.4 0.5 -0.6 -0.2 1.1 -1.3 -0.3 1.0 1.2 0.6 0.8 1.1
Medication: Levothyroxine sodium 1.3 2.1 6.1 1.8 2.2 -1.1 -1.1 -1.3 -0.3 -1.6 1.9 0.3 -1.5 2.5 -0.2 -0.1 -1.9 -1.0 -1.3 -1.9
Sitting height 0.1 0.9 4.7 0.2 -0.4 1.4 0.4 -0.4 -2.2 -1.8 0.0 0.3 0.4 0.7 -1.8 -0.0 0.8 0.7 0.4 -0.0
Chronic bronchitis/emphysema (father) 0.8 0.9 3.2 -1.2 -0.5 0.6 0.9 1.8 0.9 1.5 -0.7 0.2 0.9 -0.6 1.0 1.4 0.5 0.4 0.8 0.9
High blood pressure (mother) 1.1 1.6 4.4 -1.1 -0.1 1.5 0.8 1.6 -1.1 2.1 -1.1 -1.1 1.4 -1.7 -0.3 1.5 0.8 1.4 0.9 1.2
Body mass index (BMI) 1.5 6.3 13.5 -2.6 -0.4 2.4 2.0 2.9 -1.2 3.5 -2.3 3.0 3.4 0.8 -0.4 2.8 3.3 2.8 3.7 1.5
Impedance of leg (left) 0.4 1.8 7.8 0.5 -0.3 -0.2 0.1 -0.4 2.5 -1.2 0.8 -1.3 -1.3 -2.0 2.8 -1.7 -0.8 -1.1 -1.4 -0.6
Leg predicted mass (left) 0.3 1.6 9.7 0.1 1.4 0.1 0.3 -0.1 -0.6 0.6 0.5 2.2 1.1 3.1 -1.3 1.5 1.0 1.0 1.4 -0.7
Trunk fat mass 1.9 8.0 18.2 -2.9 0.0 3.1 2.5 3.2 -0.6 3.7 -2.1 3.5 3.9 1.5 0.2 3.2 3.5 3.4 4.3 1.4
Waist circumference 1.1 4.1 11.2 -1.8 1.0 1.8 1.2 2.1 -0.7 2.4 -1.3 3.2 2.8 2.3 -0.1 1.8 2.4 2.4 3.4 0.3
Number of incorrect matches in round 0.6 1.0 5.3 1.3 0.2 0.0 0.2 -1.4 1.5 -0.3 1.1 -2.3 -0.5 -0.6 0.5 -0.5 -0.9 -0.9 -1.2 -0.3
Past tobacco smoking 0.9 1.7 3.8 -1.4 -1.1 1.0 0.3 1.4 -1.1 0.3 -1.9 1.7 1.4 -1.4 -0.5 1.0 1.8 1.3 1.7 1.2
Alcohol usually taken with meals 3.0 4.9 10.0 2.8 1.5 -2.8 -1.8 -2.3 1.0 -2.1 2.4 -3.1 -2.5 -0.8 0.9 -2.0 -2.8 -2.1 -3.2 -1.5
Nervous feelings 0.5 1.0 3.1 -1.8 -0.5 1.7 1.2 1.5 -0.2 1.1 -0.5 0.4 1.1 0.1 0.9 0.3 0.7 0.8 1.0 0.7
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 4.0 -1.5 -0.1 0.7 1.0 1.8 -1.1 2.0 -1.1 1.5 1.2 0.1 0.4 1.2 1.3 0.8 1.5 0.4
Hearing difficulty/problems with background noise 0.9 1.5 3.2 -1.4 -1.5 0.9 1.4 1.8 0.5 1.5 -1.0 0.4 1.2 -1.4 0.6 0.3 1.6 1.2 1.2 1.4
Hair/balding pattern: Pattern 2 0.5 0.7 4.1 -0.2 -0.9 -0.2 -1.3 -0.1 -0.3 -0.4 -0.1 -2.0 -0.3 -1.5 0.1 -0.3 -0.5 -0.6 -0.8 0.7
Had menopause 1.7 2.1 7.7 -1.7 -1.6 0.5 -0.2 1.4 -1.4 0.3 -2.8 1.6 1.3 -0.9 -1.3 1.2 1.4 1.5 1.8 1.7
Had other major operations 0.6 0.8 3.2 0.1 0.5 0.3 1.2 0.2 1.2 1.6 -0.5 -0.0 0.7 -1.1 1.8 0.3 1.0 0.1 0.7 0.1
Forced vital capacity (FVC) 0.2 0.7 3.3 1.0 1.0 -0.1 -0.3 -0.9 -0.0 -0.4 1.1 -0.2 -0.4 1.8 -0.9 0.9 -0.6 0.0 -0.7 -0.9
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 4.5 -0.7 0.5 -0.3 0.4 1.2 -0.4 0.3 -0.7 2.1 1.0 0.6 -1.2 1.8 0.7 1.3 1.5 0.4
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.6 0.1 0.6 -0.0 -0.7 -0.1 0.1 -0.8 0.1 1.1 -0.5 1.3 0.8 -1.3 -0.1 -0.5 0.0 -1.0
Qualifications: None of the above 0.2 0.5 2.5 0.1 0.4 0.4 0.2 0.6 1.6 0.8 -0.4 -1.3 0.6 -0.9 1.1 0.5 0.2 -0.0 0.2 0.3
Financial difficulties in last 2 years 0.4 0.6 2.3 -0.4 1.4 0.3 -0.4 1.0 0.4 0.7 0.4 1.5 0.1 0.8 1.1 -0.8 -0.1 -0.1 0.6 -0.6
Mouth/teeth dental problems 1.2 1.8 4.5 0.9 -0.7 -1.9 -2.0 -1.8 -0.3 -2.1 0.4 -0.6 -1.6 -0.1 -0.9 -2.1 -1.2 -1.2 -1.6 -0.4
Heart attack 0.3 0.3 1.3 -0.5 -0.6 1.0 0.5 0.5 -0.2 0.6 0.2 -0.0 0.5 -0.8 0.2 1.1 0.7 0.3 0.4 0.4
Allergy 0.5 1.1 3.6 -1.1 0.2 -0.1 0.2 1.6 -1.4 1.1 -1.0 1.9 1.0 1.2 -0.5 0.6 1.0 0.9 1.4 0.1
Pain all over the body in last month 0.8 0.9 3.0 0.7 1.4 -0.2 0.7 -0.4 1.7 0.4 0.6 -0.7 -0.4 0.7 1.7 -1.2 -0.9 -0.5 -0.6 -1.2
Diabetes (self-reported) 1.1 1.7 3.1 -1.2 -0.7 1.4 0.6 1.0 -1.8 0.5 -1.7 1.5 1.5 -0.8 -1.5 0.8 1.4 1.5 1.8 1.4
Hayfever/allergic rhinitis (self-reported) 0.8 1.0 5.8 1.0 -0.1 -0.4 0.7 -0.8 2.0 0.1 1.0 -2.4 -0.5 -0.2 1.0 0.0 -1.0 -0.7 -1.3 -0.2
Medication: Ramipril 2.0 2.6 4.5 1.9 1.2 -1.2 -1.4 -1.8 2.1 -1.9 1.8 -1.9 -1.2 -0.3 2.1 -1.1 -0.9 -1.8 -1.7 -1.6
Medication: Simvastatin 0.4 0.6 2.5 -0.9 -0.7 0.6 0.1 0.9 -1.6 0.3 -0.7 1.2 0.4 -0.6 -0.8 0.1 1.0 0.3 0.8 0.6
Fluid intelligence score 0.2 0.3 1.7 0.1 -0.5 -1.1 -0.3 0.3 -0.7 -1.3 0.1 1.0 -0.4 -0.6 0.3 0.1 -0.0 0.4 -0.0 0.1
Illnesses of siblings 0.5 0.7 4.2 0.9 0.7 -0.4 -0.2 -0.6 2.0 0.6 1.0 -1.2 -0.1 0.8 1.1 0.5 -0.3 -0.1 -0.6 -0.7
Neuroticism score 0.7 1.5 5.0 -1.9 -1.1 1.5 0.4 1.9 1.2 1.4 -0.6 0.1 1.1 -1.0 2.2 -0.3 1.2 0.4 1.0 0.8
Weight 0.6 2.7 7.8 -1.0 1.0 1.3 1.2 1.4 -0.6 1.8 -0.5 2.8 2.1 2.4 -0.2 1.8 2.1 1.8 2.6 -0.1
Impedance of arm (right) 0.8 3.6 7.1 -2.5 -1.0 2.2 1.2 2.7 -0.6 2.0 -1.9 0.8 2.5 -1.1 0.8 2.6 1.5 2.5 2.2 2.0
Arm fat percentage (right) 3.1 12.4 26.4 -3.9 -0.8 3.9 3.1 4.3 -1.2 5.1 -3.4 3.3 4.8 0.5 0.1 4.0 4.0 4.0 4.9 2.5
Trunk fat-free mass 1.0 5.9 11.4 3.2 2.9 -2.4 -1.2 -3.1 1.4 -2.6 3.3 0.1 -2.5 3.4 -0.3 -1.9 -1.9 -2.2 -2.1 -3.3
Hip circumference 0.5 2.3 5.8 -0.5 1.7 1.1 1.0 1.1 0.1 1.8 -0.0 2.4 1.8 2.4 0.0 1.6 1.7 1.8 2.3 -0.4
Time employed in main current job 0.4 0.4 1.9 0.8 1.4 -0.7 -0.0 -0.0 -0.1 0.4 0.6 0.5 -0.6 0.6 0.8 -0.4 -0.6 -0.5 -0.1 -1.0
Alcohol intake versus 10 years previously 0.2 0.3 1.2 -0.1 -0.2 -0.1 0.1 -0.2 0.7 -0.8 0.6 1.1 -0.3 0.9 0.9 0.1 -0.0 -0.3 0.1 -0.6
Father’s age at death 0.2 0.3 1.8 0.1 0.2 0.3 0.1 -0.4 0.9 0.4 0.6 -0.5 0.5 1.3 -0.2 0.4 -0.3 0.8 0.0 -0.2
Worrier / anxious feelings 0.3 0.6 1.1 0.6 0.9 -0.4 -1.0 -0.9 0.3 -0.9 0.8 -0.5 -0.7 0.8 0.4 -0.3 -1.0 -0.8 -0.7 -0.9
Frequency of tiredness / lethargy in last 2 weeks 3.0 4.9 10.4 -2.8 -2.4 2.5 1.3 2.0 -1.1 2.2 -2.4 0.9 3.0 -0.6 -0.3 3.2 2.7 2.2 2.8 2.2
Falls in the last year 2.0 2.7 4.9 -2.0 -1.7 1.7 0.6 1.3 -1.2 1.0 -2.0 1.2 2.1 -1.3 -0.8 1.9 2.0 1.8 2.2 2.1
Hair/balding pattern: Pattern 3 0.4 0.6 1.4 -0.9 -0.8 1.1 1.2 0.2 -1.2 -0.5 -1.0 0.7 0.5 -0.4 -1.1 0.5 0.5 0.8 0.7 0.7
Number of live births 0.5 0.7 2.2 -0.8 -1.2 0.9 0.3 0.7 -0.6 -0.4 -1.2 -0.4 0.3 -1.3 -1.2 -0.6 0.3 0.9 0.1 1.5
Forced expiratory volume in 1-second (FEV1) 1.0 3.2 6.4 2.4 1.5 -1.4 -1.0 -2.5 1.9 -1.3 2.5 -2.0 -1.8 1.8 0.2 -0.5 -1.9 -1.4 -2.5 -1.8
Pulse rate 0.5 0.8 2.3 -1.1 -1.1 0.9 0.2 0.9 -0.6 1.5 -1.4 -0.2 1.0 -1.1 0.4 0.4 0.6 0.5 0.7 1.1
Happiness 1.0 1.2 3.5 -1.0 0.1 1.3 1.1 1.8 -0.3 1.9 -1.2 0.2 1.5 0.1 0.0 1.2 1.0 1.1 1.3 0.8
Noisy workplace 0.5 0.7 3.3 0.1 -0.9 -0.6 -0.5 -0.4 0.1 -0.7 0.6 0.4 -1.2 0.1 0.4 -1.6 -0.6 -1.8 -0.7 -0.5
Qualifications: A levels/AS levels or equivalent 0.3 0.6 3.6 0.4 0.7 -0.8 -0.3 -0.8 -0.2 -0.8 0.6 0.8 -0.6 1.9 -1.0 -0.1 -0.7 -0.0 -0.3 -0.8
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 4.7 -1.1 -2.0 0.1 0.6 1.0 -1.0 0.2 -1.1 0.0 0.6 -2.2 0.3 1.1 0.7 0.7 0.7 1.7
Mouth/teeth dental problems: Dentures 0.9 1.6 7.9 -0.2 1.0 2.1 2.8 1.3 0.5 2.5 0.0 -0.0 0.9 -0.2 1.5 0.7 0.7 0.5 0.8 -0.1
Asthma 0.8 1.6 7.3 -1.3 -2.1 0.5 -0.1 0.5 0.1 0.3 -2.1 -0.6 1.1 -2.7 -0.1 1.0 1.2 0.6 0.8 1.8
Medication: Ibuprofen (e.g. Nurofen) 2.1 2.7 9.1 1.6 0.9 -3.0 -1.9 -1.8 2.5 -1.7 1.4 -0.4 -1.8 0.8 0.9 -1.5 -1.2 -1.5 -1.7 -1.4
Medication: Cholesterol lowering 0.5 0.8 2.4 -0.6 -0.0 1.0 1.2 0.2 -1.2 0.8 -0.3 1.5 0.5 0.9 -1.5 0.8 0.7 0.6 1.1 -0.0
Depression (self-reported) 0.5 0.6 1.6 -1.2 -0.6 0.4 -0.1 0.8 0.4 0.4 -1.1 0.8 0.9 -0.6 0.7 1.0 0.9 0.1 1.0 0.7
Medication: Lansoprazole 0.5 0.6 2.9 -0.9 -0.5 1.7 1.4 0.3 -0.9 0.6 -0.5 0.4 0.6 -0.1 -0.1 0.8 0.7 0.3 0.7 0.4
Prospective memory result 0.3 0.3 1.8 -0.4 -0.2 1.4 0.3 -0.0 0.0 0.2 -0.5 -0.8 0.5 -0.2 -0.9 1.1 0.3 0.4 0.1 0.5
Lung cancer (father) 3.1 3.6 8.5 -2.4 -2.9 1.2 1.6 2.5 -2.2 0.7 -2.5 1.3 1.3 -1.9 -1.5 1.5 1.8 1.6 1.4 2.5
Illnesses of mother 2.7 3.4 6.0 1.8 1.3 -1.6 -1.3 -2.0 1.6 -2.0 2.0 -1.1 -2.2 1.9 0.7 -2.5 -2.3 -2.0 -2.2 -1.9
Forced expiratory volume in 1-second (FEV1), Best measure 1.8 5.8 10.7 3.2 2.5 -2.2 -1.6 -3.3 2.2 -1.6 3.2 -1.7 -2.4 2.5 0.9 -1.0 -2.4 -2.3 -2.9 -3.0
Pulse wave Arterial Stiffness index 1.0 1.1 4.0 0.6 -0.5 -1.0 -1.3 -1.3 -0.2 -2.0 -0.3 -1.3 -1.2 -0.7 -0.6 -1.5 -1.2 -0.8 -1.4 0.2
Impedance of arm (left) 1.0 4.5 8.9 -2.8 -1.4 2.5 1.5 3.0 -0.9 2.0 -2.2 0.8 2.7 -1.3 0.6 2.8 1.8 2.8 2.4 2.3
Arm fat mass (right) 1.7 6.8 14.6 -2.6 0.1 2.6 2.3 3.1 -0.8 3.8 -2.1 3.1 3.5 1.3 -0.0 3.0 3.2 2.9 3.8 1.2
Trunk predicted mass 1.0 5.8 11.3 3.2 2.8 -2.3 -1.2 -3.1 1.4 -2.6 3.2 0.1 -2.5 3.4 -0.3 -2.0 -1.9 -2.2 -2.1 -3.2
Standing height 0.8 8.3 18.8 3.8 3.7 -2.3 -1.6 -3.4 1.9 -3.5 4.3 -0.3 -2.8 3.8 0.6 -2.1 -2.4 -2.1 -2.5 -3.9
Length of working week for main job 1.7 1.9 9.0 -1.0 -0.8 0.4 1.3 1.4 -0.9 1.5 -0.9 1.1 1.8 -0.4 -0.3 3.0 1.7 1.3 1.8 1.2
Exposure to tobacco smoke at home 0.3 0.3 1.0 0.3 0.6 -0.9 0.1 -0.8 -0.5 0.1 0.6 -0.5 -0.5 0.6 -0.1 -1.0 -0.5 -0.8 -0.5 -0.5
Breastfed as a baby 4.1 5.0 9.5 2.7 1.6 -2.7 -2.2 -2.1 0.9 -1.7 2.0 -1.8 -3.0 -0.3 0.6 -3.1 -2.7 -3.0 -3.0 -2.0
Tense / ‘highly strung’ 0.4 0.7 2.4 -1.0 -0.7 1.2 0.7 1.5 0.3 0.8 -0.1 -0.4 0.9 -1.1 0.8 0.3 1.1 0.6 0.7 0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 5.0 -0.5 1.6 0.4 -0.3 1.0 -0.6 0.8 -0.4 2.2 1.1 1.6 -0.2 1.2 0.9 0.8 1.7 -0.4
Hair/balding pattern: Pattern 4 0.6 1.5 9.2 -0.5 0.9 -0.4 -0.8 0.4 -1.3 -0.5 -0.1 2.3 0.8 3.0 -1.8 0.5 0.2 1.2 1.4 -0.3
Birth weight of first child 0.6 1.0 3.7 -0.3 0.0 0.1 0.3 0.1 -1.8 -0.3 -0.2 1.5 0.8 1.9 -1.7 1.3 0.4 1.3 1.1 -0.0
Peak expiratory flow (PEF) 2.0 4.7 10.4 2.5 1.0 -2.1 -2.1 -3.2 1.8 -2.6 2.3 -2.6 -2.4 1.3 0.3 -0.7 -2.6 -2.0 -3.0 -1.8
Pulse wave reflection index 1.4 1.7 3.5 1.4 0.8 -1.8 -1.2 -1.6 1.0 -1.9 1.0 -0.8 -1.5 0.8 0.9 -1.5 -1.1 -1.4 -1.5 -1.3
Ever highly irritable/argumentative for 2 days 1.7 2.0 7.7 -1.6 -0.6 1.0 0.0 1.8 -2.4 0.1 -1.1 2.8 1.0 -0.5 -1.5 0.8 1.3 1.4 1.8 1.1
Loud music exposure frequency 0.7 0.7 3.6 0.7 1.5 0.2 -0.5 -0.6 0.2 -0.3 1.0 1.1 -0.4 1.9 -1.1 -0.0 -0.4 -0.6 0.1 -1.3
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 4.1 1.0 1.5 -0.9 -0.6 -1.1 0.6 -0.8 0.9 1.5 -0.9 2.0 0.0 -1.2 -0.4 -0.8 -0.3 -1.6
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.6 0.2 0.5 -0.1 0.1 -0.2 0.3 -0.3 0.4 -0.4 -0.2 0.8 0.2 0.3 -0.3 0.2 -0.2 -0.3
Blood clot in the leg (DVT) 0.6 0.8 6.5 -0.0 -0.6 0.8 0.5 -0.8 -1.7 -1.0 -0.0 -0.7 -0.3 0.7 -2.5 0.2 -0.7 0.0 -0.6 0.1
Medication: Paracetamol 0.6 1.0 2.7 0.8 1.2 -0.9 -1.0 -1.1 1.5 0.2 1.3 0.1 -0.8 1.7 0.8 -1.1 -0.3 -0.5 -0.6 -1.3
Headache pain in last month 0.3 0.6 3.1 0.2 1.4 0.1 -0.2 -0.1 0.8 -0.2 0.9 0.9 -0.2 1.8 0.9 0.2 -0.3 -0.2 -0.0 -1.2
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 2.2 0.3 0.6 -0.4 0.9 0.2 1.0 0.7 0.6 0.3 -0.6 1.0 1.5 -0.7 -0.4 -0.5 -0.5 -0.7
Glaucoma (self-reported) 1.3 1.6 5.1 1.1 0.5 -1.3 -1.4 -2.3 1.9 -0.9 0.6 -0.8 -1.3 0.4 0.4 -0.7 -1.4 -1.8 -1.4 -1.1
Gout (self-reported) 0.2 0.2 0.9 -0.4 -0.6 0.0 -0.6 -0.4 -0.3 -1.0 -0.7 0.1 0.1 -0.6 -0.2 -0.5 0.4 -0.3 0.1 0.5
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 1.8 0.3 0.9 0.4 -0.0 -0.1 -0.6 -0.2 0.3 0.9 -0.3 1.4 -0.4 1.0 -0.5 -0.0 -0.1 -0.6
Medication: Amlodipine 0.6 0.8 2.9 0.0 -1.0 -1.2 -1.6 -0.5 -0.7 -1.7 -0.0 -0.8 -0.9 -1.7 0.2 -0.5 -0.4 -0.7 -0.8 0.4
Medication: Ventolin 100micrograms inhaler 0.9 1.2 3.1 -1.4 -1.1 1.1 0.3 1.3 -0.6 1.1 -1.8 0.9 1.3 -0.7 0.6 -0.1 1.5 1.0 1.5 0.9
Birth weight 2.3 4.9 8.8 -2.5 -1.7 1.8 2.2 2.8 -2.4 2.5 -2.1 3.0 2.2 0.7 -1.8 2.2 2.2 2.4 2.6 1.8
Chronic bronchitis/emphysema (mother) 0.2 0.3 1.2 -0.4 -0.7 0.1 -0.1 -0.0 -0.6 -1.0 -0.1 -0.4 -0.2 -0.3 -0.6 1.1 -0.3 -0.1 -0.3 0.3
High blood pressure (siblings) 0.2 0.3 2.8 -0.6 -0.3 0.3 -0.0 0.4 -1.7 -0.5 -0.5 0.9 -0.2 -0.2 -0.9 -0.2 -0.1 0.1 0.2 0.2
Forced vital capacity (FVC), Best measure 1.0 3.7 7.3 2.6 2.5 -1.9 -1.5 -2.4 1.3 -1.3 2.5 -0.7 -1.9 2.5 0.8 -0.7 -1.9 -1.8 -2.0 -2.7
Body fat percentage 3.2 12.5 25.2 -4.0 -1.1 4.0 3.1 4.4 -0.8 4.7 -3.4 3.4 4.8 0.0 0.5 3.7 4.3 4.1 5.0 2.6
Leg fat percentage (right) 2.5 9.1 18.1 -3.5 -1.2 3.3 2.9 3.8 -0.5 3.9 -3.3 3.3 3.9 -0.5 0.5 2.7 3.8 3.2 4.3 2.2
Arm fat-free mass (right) 0.6 2.9 8.1 2.2 2.0 -1.6 -0.9 -2.2 0.8 -2.0 2.3 0.6 -1.6 2.9 -0.6 -1.4 -0.9 -1.3 -1.1 -2.4
Exposure to tobacco smoke outside home 0.6 0.9 2.5 -1.2 -0.5 1.3 0.1 1.6 0.0 1.0 -0.7 0.1 1.3 -0.4 0.5 1.3 0.9 0.9 1.1 0.9
Comparative body size at age 10 2.0 5.6 13.2 -2.5 -1.8 1.9 -0.1 2.2 -3.6 0.9 -3.0 2.1 2.7 0.2 -3.2 2.4 2.1 3.1 2.8 2.2
Number of full brothers 0.3 0.4 1.3 -0.6 0.2 0.7 0.9 0.8 0.6 0.9 -0.4 -0.3 0.4 -0.1 0.5 1.1 0.4 0.0 0.3 0.3
Worry too long after embarrassment 1.0 1.7 5.2 -1.8 -1.4 1.4 0.8 2.3 0.0 2.0 -1.4 -0.4 1.5 -0.9 0.7 1.1 1.3 0.9 1.2 1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.5 4.0 1.3 1.6 -1.3 -1.6 -1.6 0.2 -2.0 1.2 0.1 -1.1 1.3 -0.1 -0.7 -1.2 -1.1 -0.8 -1.4
Wheeze or whistling in the chest in last year 0.9 1.7 5.1 -1.1 -1.3 1.4 1.3 1.3 0.8 1.2 -1.9 0.1 1.0 -2.2 1.6 0.8 1.5 0.4 1.1 1.1
Number of children fathered 1.9 2.2 5.9 1.9 0.6 -2.4 -1.3 -2.1 0.4 -1.2 1.8 -1.7 -1.6 -0.2 0.7 -1.3 -1.2 -1.5 -1.9 -1.2
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 1.4 0.8 0.9 -0.4 -0.5 -1.2 0.2 -0.9 1.1 -0.1 -0.2 1.0 -0.4 0.1 -0.3 0.6 -0.1 -0.7
Age at first live birth 0.4 0.8 2.6 0.7 -0.0 -1.1 -0.6 -1.3 1.6 -1.6 0.9 -0.3 -1.0 -0.0 0.5 -0.7 -0.8 -0.6 -0.9 -0.6
Pulse wave peak to peak time 0.9 1.1 3.8 -0.4 0.7 0.9 1.3 1.1 0.4 1.9 0.5 1.2 1.1 0.8 0.6 1.4 1.1 0.8 1.3 -0.3
Health satisfaction 0.8 1.0 4.9 -1.2 -0.2 1.5 1.0 1.3 -0.5 0.6 -0.8 2.2 0.9 0.5 0.5 0.2 1.2 0.5 1.5 0.3
Shortness of breath walking on level ground 0.1 0.1 0.8 0.2 0.1 0.1 0.0 -0.4 0.6 0.1 -0.3 -0.1 -0.0 -0.6 0.9 0.3 -0.1 -0.1 -0.1 -0.1
Qualifications: College or University degree 0.2 0.6 2.6 0.7 0.3 -0.9 -1.3 -1.1 0.3 -0.7 1.0 0.7 -0.4 1.6 -0.3 0.1 -0.4 -0.1 -0.3 -0.8
Eye problems/disorders: None of the above 0.5 0.6 2.6 -0.1 -0.4 0.1 0.7 0.9 -0.2 0.6 -0.2 -1.6 0.6 -1.5 -0.7 1.0 0.2 0.9 -0.1 1.0
Mouth/teeth dental problems: Loose teeth 0.4 0.4 1.0 0.2 -0.7 -0.7 -0.6 -0.8 0.9 -0.7 -0.3 -0.2 -0.9 -0.6 0.1 -0.9 -0.5 -1.0 -0.8 -0.1
Emphysema/chronic bronchitis 0.7 0.8 2.4 1.0 0.9 -0.6 -0.5 -0.7 1.6 0.2 1.2 -0.9 -0.8 0.9 1.0 -0.5 -1.1 -1.1 -0.8 -0.9
Medication for pain relief, constipation, heartburn 0.6 1.1 2.8 -1.2 -1.3 1.7 1.1 1.0 -0.7 0.4 -1.5 0.1 1.0 -1.4 -0.4 0.5 0.6 0.7 0.7 1.5
Neck or shoulder pain in last month 1.4 1.9 4.5 -2.1 -1.8 0.6 -0.4 1.0 -0.1 1.0 -2.1 1.8 1.7 0.6 0.0 1.3 1.9 0.7 2.1 1.2
Medication: Blood pressure 0.3 0.5 4.3 0.2 0.0 -0.3 -2.1 -0.5 -0.1 -1.5 0.0 -0.9 0.2 -0.9 -0.3 0.3 -0.1 -0.1 -0.1 0.2
Angina (self-reported) 0.5 0.6 4.7 -0.4 0.6 1.2 2.2 0.9 -0.3 1.1 -0.1 0.6 0.3 -0.2 0.1 0.2 0.4 0.6 0.5 -0.1
Migraine (self-reported) 0.2 0.3 2.2 0.1 0.2 0.7 0.2 0.0 -1.5 0.2 0.6 -0.1 -0.1 0.8 -0.5 0.4 -0.3 0.6 -0.2 -0.3
Medication: Ibuprofen 2.4 2.9 6.9 1.9 1.4 -2.6 -1.5 -1.7 2.1 -1.8 1.8 -0.4 -2.1 0.5 1.2 -1.7 -1.4 -1.8 -1.9 -1.7
Medication: Allopurinol 0.4 0.5 2.1 -0.6 -0.8 0.8 0.4 0.1 -0.8 -0.3 -1.2 -0.3 0.6 -1.4 -0.5 0.6 0.4 0.1 0.3 1.1
Medication: Omeprazole 0.5 0.6 3.6 -0.2 0.6 0.3 1.2 1.3 -0.7 1.9 0.4 0.2 0.7 0.3 0.3 1.1 0.4 0.5 0.7 -0.0
Medication: Seretide 50 evohaler 0.3 0.4 1.2 0.4 -0.4 -0.6 -1.0 -1.0 0.3 -0.5 -0.4 -0.6 -0.2 0.3 1.1 -0.0 -0.2 -1.1 -0.2 -0.6
Mean time to correctly identify matches 0.8 1.6 3.3 -1.8 -0.7 1.8 0.3 1.7 -1.5 0.9 -1.4 0.8 1.4 -0.0 -1.4 1.2 1.0 1.2 1.5 1.3
Heart disease (mother) 1.2 1.5 3.2 -1.4 -1.4 0.2 -0.6 1.2 -0.5 0.9 -1.7 1.0 1.5 -1.1 -0.5 1.1 1.8 1.2 1.7 1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 4.3 -1.1 -1.2 0.9 2.1 1.2 -0.1 1.7 -1.3 -0.0 1.1 -1.4 -0.1 -0.0 0.7 1.3 0.8 1.7
Whole body fat mass 1.8 7.6 16.6 -2.9 -0.2 3.1 2.7 3.2 -0.8 3.6 -2.2 3.4 3.7 1.2 0.0 3.0 3.4 3.2 4.1 1.4
Leg fat mass (right) 1.8 6.9 15.4 -2.8 -0.3 2.7 2.3 3.1 -0.6 3.4 -2.4 3.5 3.5 0.8 0.2 2.5 3.5 2.8 3.9 1.4
Arm predicted mass (right) 0.5 2.6 8.4 2.0 1.8 -1.6 -0.9 -2.1 0.6 -1.9 2.2 0.9 -1.5 2.9 -0.6 -1.1 -0.7 -1.2 -0.9 -2.3
Pulse rate, automated reading 0.4 1.2 3.3 -1.3 -1.8 1.0 -0.3 0.5 -0.7 0.5 -1.8 0.1 1.3 -1.2 -0.0 0.6 1.4 0.6 1.3 1.3
Alcohol intake frequency. 1.6 3.7 6.6 -2.5 -1.0 1.8 1.2 2.6 -1.6 2.3 -2.2 2.4 2.0 0.1 -0.7 2.3 1.9 1.9 2.5 1.4
Comparative height size at age 10 0.5 2.7 5.7 2.1 1.2 -1.6 -1.5 -2.4 1.6 -2.3 2.0 -0.5 -1.6 1.7 0.7 -1.3 -1.7 -1.6 -1.6 -1.7
Number of full sisters 0.9 1.1 2.8 -1.2 -1.4 0.8 0.8 1.1 -0.4 1.5 -1.7 0.3 0.9 -1.7 -0.7 0.2 1.0 0.6 1.0 1.4
Suffer from ‘nerves’ 0.3 0.5 3.1 -0.5 0.7 0.7 -0.5 0.4 0.6 -0.4 0.8 0.9 -0.0 0.9 1.8 0.3 0.0 -0.4 0.3 -0.9
Overall health rating 2.7 5.8 10.9 -3.3 -2.5 2.2 1.0 3.2 -1.2 2.0 -3.1 2.5 2.8 -1.4 0.1 1.8 3.1 2.2 3.3 2.4
Chest pain or discomfort 0.3 0.5 1.9 -0.0 -0.5 0.1 0.2 -0.2 -1.4 -1.1 -1.2 1.2 -0.2 -0.3 -0.9 1.0 -0.0 -0.2 0.3 0.1
Had major operations 0.4 0.5 1.9 0.4 -0.2 -0.3 -0.6 -1.4 0.7 -1.0 0.8 0.2 -0.7 1.0 -0.4 -0.6 -0.5 -0.5 -0.4 -0.6
Age at last live birth 0.4 0.5 2.2 0.2 -0.2 -0.7 -0.7 -0.8 1.5 -1.2 0.3 -0.5 -0.7 -0.2 0.4 -0.9 -0.8 -0.5 -0.8 -0.1
Family relationship satisfaction 1.1 1.3 3.8 -1.5 0.3 1.2 1.4 1.9 -0.7 1.7 -0.9 1.3 1.2 0.6 0.1 0.7 1.2 0.9 1.5 0.7
Leg pain on walking 0.2 0.3 1.0 0.4 0.4 0.9 0.9 -0.7 -0.5 0.3 0.3 -1.0 -0.3 -0.1 -0.0 0.6 -0.4 -0.2 -0.4 -0.3
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 0.9 -0.6 -0.1 0.6 0.9 0.8 -0.0 0.9 0.3 0.4 0.2 0.0 0.8 -0.5 0.4 0.3 0.2 0.1
Commuting to job workplace: Car/motor vehicle 0.3 0.3 1.0 0.0 -0.1 -0.3 0.9 0.1 0.5 1.0 -0.7 0.6 -0.3 -1.0 0.9 -0.7 0.2 -0.6 0.1 0.0
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 1.0 1.0 0.6 -0.3 0.1 -0.9 0.8 0.0 0.5 -1.0 -0.4 0.4 -0.5 0.3 -0.6 -0.2 -0.8 -0.5
Medication: Aspirin 1.5 1.9 6.5 -1.1 -0.0 1.0 0.8 1.8 -2.5 1.4 -1.3 1.9 1.4 0.7 -1.5 1.2 1.2 1.2 1.9 0.5
Supplements: Vitamin C 0.8 1.0 2.8 0.6 1.2 -0.4 -0.1 -1.0 0.9 -0.6 0.7 0.2 -0.8 1.7 1.0 -1.6 -1.0 -1.0 -0.6 -1.6
Knee pain experienced in last month 0.4 0.6 1.9 -0.7 -0.5 0.4 -0.1 0.8 -1.2 0.1 -0.4 1.1 0.9 0.3 0.0 1.4 1.3 0.7 1.2 0.3
Hypertension (Self-reported) 0.6 1.7 7.8 0.9 0.7 -1.5 -2.8 -0.8 0.2 -2.6 0.6 -1.9 -0.9 -1.2 0.5 -0.4 -1.1 -1.1 -1.3 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 3.2 0.8 -0.2 -0.6 -0.2 -0.8 1.1 -0.8 0.9 -1.8 -0.5 -0.8 0.6 0.0 -0.6 -0.7 -0.9 -0.2
Illnesses of father: Heart disease 0.3 0.5 2.1 0.4 1.4 0.8 0.9 -0.3 0.4 0.6 0.6 0.1 0.1 1.4 0.5 -0.1 -0.2 0.0 0.3 -0.9
Illnesses of siblings: Diabetes 0.5 0.6 1.5 -1.1 -1.1 1.0 -0.2 0.7 -0.2 0.4 -1.2 -0.1 0.8 -1.2 0.3 0.1 1.1 0.4 0.7 1.1
Smoking status: Previous 0.8 1.1 4.8 1.1 0.5 -0.6 -0.3 -1.1 1.1 -0.2 1.6 -2.2 -1.1 0.3 0.3 -0.5 -1.5 -0.8 -1.7 -0.5
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.3 5.2 1.9 1.9 -0.9 -1.3 -1.7 1.3 -1.3 2.0 -0.7 -1.3 2.1 1.0 -1.1 -1.1 -1.4 -1.3 -2.3
Whole body fat-free mass 0.5 2.7 11.6 2.1 2.3 -1.5 -0.7 -2.0 0.6 -1.4 2.3 0.9 -1.1 3.4 -0.7 -0.6 -0.8 -1.0 -0.8 -2.3
Leg fat-free mass (right) 0.3 1.5 11.1 0.4 1.4 -0.2 0.1 -0.3 -0.5 0.5 0.8 1.9 0.8 3.3 -1.2 1.4 0.8 0.8 1.1 -0.9
Arm fat percentage (left) 3.8 15.1 28.9 -4.4 -1.4 4.2 3.4 4.8 -1.4 5.4 -3.9 3.5 5.2 0.1 -0.1 4.4 4.5 4.5 5.3 3.0
Average weekly red wine intake 0.5 0.7 1.7 0.7 0.2 -0.2 0.9 -1.2 -0.7 -1.0 0.4 -1.0 -1.0 -0.2 -1.0 -1.3 -1.2 -0.4 -1.2 -0.3
Handedness (chirality/laterality): Left-handed 0.1 0.2 1.1 -0.5 -0.5 -0.2 -0.3 -0.2 -0.8 0.2 0.1 0.4 -0.1 1.1 0.2 -0.1 -0.1 -0.2 0.1 -0.2
Mood swings 0.5 0.9 7.3 -0.7 -0.5 -0.3 -0.5 0.2 2.2 0.4 -0.2 -0.1 0.1 -0.2 2.7 -1.0 0.2 -0.9 0.1 -0.3
Loneliness, isolation 0.3 0.4 1.4 -0.8 0.2 -0.3 -0.4 1.1 0.0 0.7 -0.6 1.1 0.2 -0.2 1.2 -0.5 0.2 -0.1 0.6 -0.0
Long-standing illness, disability or infirmity 0.4 0.6 3.4 -0.7 0.3 0.2 0.2 0.9 -0.2 0.5 -0.3 1.8 0.6 -0.2 0.7 0.8 1.1 0.4 1.3 -0.0
Ever had bowel cancer screening 0.2 0.2 0.8 0.3 0.3 0.5 0.1 -0.5 -0.5 -0.3 0.1 0.1 -0.5 -0.7 -0.4 -0.6 -0.2 -0.9 -0.4 -0.0
Diabetes diagnosed by doctor 1.6 2.6 7.8 -1.3 -0.5 1.5 0.8 1.0 -2.8 0.6 -1.6 2.6 1.5 0.1 -2.4 1.4 1.4 1.5 2.2 1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.5 0.4 1.2 0.5 0.8 0.2 1.0 0.8 0.9 -0.1 -0.0 1.2 1.2 0.4 -0.4 -0.1 -0.2 -0.7
Friendships satisfaction 1.1 1.4 3.3 -1.8 -0.7 1.2 0.4 1.7 -1.0 0.6 -1.6 1.8 1.3 0.8 -0.5 0.9 1.0 0.7 1.7 0.8
Qualifications: nursing, teaching 0.3 0.4 2.1 0.1 0.2 0.3 0.3 -0.3 0.2 1.0 -0.5 1.0 0.4 -1.4 0.5 -0.2 1.3 0.3 0.6 0.4
Commuting to job workplace: Walk 0.3 0.3 1.4 0.5 0.6 -0.7 0.1 -0.3 0.3 0.3 1.2 0.1 -0.1 1.2 0.1 -0.5 -0.0 -0.1 -0.1 -0.6
Eye problems/disorders: Cataract 0.2 0.2 0.9 -0.0 0.7 0.4 -0.0 -0.4 -0.3 0.5 0.3 0.4 0.2 0.9 0.4 -0.4 0.2 0.0 0.2 -0.5
Mouth/teeth dental problems: Mouth ulcers 2.0 3.2 7.8 -1.6 0.9 1.3 1.5 2.5 0.4 2.8 -1.5 2.1 2.3 0.0 0.6 2.0 2.2 2.0 2.6 0.9
Medication for cholesterol 0.6 1.0 5.5 0.3 -0.6 -1.3 -1.1 -1.4 2.3 -0.7 0.5 -0.2 -0.6 0.9 0.8 -1.4 -0.6 -0.5 -0.6 -0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 1.8 0.5 0.4 -0.5 -0.4 -0.2 1.4 0.6 0.8 -0.9 -0.2 0.2 1.3 0.7 -0.4 -0.4 -0.5 -0.5
Back pain experienced in last month 2.3 3.4 8.9 -2.1 -1.5 2.2 1.6 1.8 0.4 2.2 -2.0 0.9 2.3 -1.0 0.8 1.5 3.0 1.7 2.5 1.7
Mineral and other dietary supplements 0.9 1.2 3.1 -1.7 -1.1 0.4 1.0 1.8 -1.4 0.7 -1.1 1.2 0.9 -1.1 -0.2 0.5 1.2 0.8 1.2 1.2
Breast cancer (self-reported) 0.3 0.4 1.6 0.2 0.8 -0.4 -0.2 0.1 1.3 1.1 0.1 -0.3 0.1 0.9 0.9 -0.4 -0.4 -0.5 0.3 -0.4
Asthma (self-reported) 0.7 1.4 7.8 -1.2 -1.9 0.6 -0.1 0.5 0.0 0.3 -1.9 -0.7 1.0 -2.8 -0.0 0.7 1.2 0.5 0.7 1.8
Osteoporosis (self-reported) 0.1 0.1 0.4 0.5 0.6 -0.2 -0.5 -0.2 0.0 0.2 0.2 0.0 -0.4 0.5 -0.2 -0.2 -0.5 -0.6 -0.2 -0.4
Osteoarthritis (self-reported) 0.4 0.5 1.3 0.4 0.6 -0.6 -0.2 -1.0 0.7 -0.5 0.6 0.6 -0.9 1.0 0.4 -0.9 -0.8 -1.1 -0.5 -0.8
Medication: Aspirin 1.3 1.8 5.7 -1.0 -0.1 1.2 0.9 1.6 -2.4 1.2 -1.2 1.8 1.4 0.5 -1.4 1.3 1.3 1.1 1.8 0.5
Medication: Gliclazide 0.5 0.6 1.2 -0.9 -0.3 0.2 -0.0 0.9 -0.8 0.6 -0.9 1.1 0.7 -0.5 -0.6 1.0 0.9 0.7 1.1 0.7
Illnesses of father: None of the above (group 1) 0.1 0.2 0.6 0.1 -0.2 -0.6 -0.8 -0.1 -0.4 -0.0 -0.6 0.4 -0.3 -0.6 -0.3 -0.5 -0.1 -0.2 -0.3 0.2
Smoking status: Current 0.1 0.2 1.2 0.4 0.5 -0.0 -0.1 -0.3 -0.4 -0.2 0.1 0.1 -0.4 1.1 0.1 -0.3 -0.4 -0.8 -0.1 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.7 3.6 6.3 2.4 2.0 -2.3 -1.6 -2.1 0.9 -1.6 2.5 -0.6 -2.4 1.5 0.6 -0.5 -2.1 -2.1 -2.3 -2.5
Whole body water mass 0.5 2.9 11.8 2.1 2.4 -1.6 -0.8 -2.0 0.6 -1.6 2.3 0.9 -1.2 3.4 -0.8 -0.7 -0.9 -1.0 -0.8 -2.4
Leg predicted mass (right) 0.3 1.5 11.2 0.4 1.5 -0.2 0.1 -0.3 -0.4 0.5 0.9 1.9 0.8 3.4 -1.1 1.4 0.8 0.8 1.2 -0.9
Arm fat mass (left) 1.7 7.2 15.3 -2.6 0.0 2.8 2.5 3.1 -1.0 3.6 -2.1 3.4 3.6 1.4 -0.2 3.0 3.3 3.0 3.9 1.3
Number of self-reported non-cancer illnesses 0.3 0.4 2.1 -0.6 -1.0 -0.1 -1.1 0.1 0.1 -0.4 -0.8 -0.1 0.5 -1.5 0.4 0.3 0.7 -0.0 0.5 0.9
Average weekly champagne plus white wine intake 0.2 0.3 0.8 0.3 0.1 -0.9 -0.3 -0.3 0.6 0.2 0.8 -0.5 -0.6 0.7 0.4 -0.2 -0.8 -0.5 -0.7 -0.6
Miserableness 0.3 0.5 2.2 -1.1 -0.3 0.6 -0.7 0.8 0.9 0.4 -0.8 0.2 0.7 -0.3 1.5 -0.3 0.7 0.2 0.8 0.2
Guilty feelings 0.9 1.4 2.9 -1.7 -1.4 1.4 0.1 1.2 1.0 1.2 -1.1 -0.2 1.2 -1.6 1.5 0.2 1.4 0.9 0.9 1.3
Wears glasses or contact lenses 0.5 0.6 4.7 0.4 0.7 -0.3 -0.3 -0.2 0.6 -0.1 0.2 0.0 -0.9 -0.0 0.8 -2.2 -0.7 -0.8 -0.8 -0.8
Ever taken oral contraceptive pill 0.3 0.3 1.3 -0.1 0.6 1.0 1.2 0.5 -0.9 0.1 0.1 -0.2 0.3 -0.2 -0.1 0.8 -0.1 0.4 0.2 0.2
Hearing aid user 0.4 0.5 1.8 0.0 0.8 1.3 0.9 0.3 0.0 1.3 0.6 1.0 0.2 0.6 0.7 -0.1 0.5 -0.3 0.7 -0.6
Mother’s age at death 0.6 0.8 4.6 -0.3 -0.2 0.6 0.3 -0.2 -1.6 -0.8 -0.3 0.0 0.7 1.3 -2.2 0.5 -0.0 1.3 0.5 0.5
Financial situation satisfaction 1.2 1.5 4.2 -1.3 0.3 1.1 1.0 1.7 -0.7 2.1 -0.6 1.2 1.6 0.9 -0.2 0.8 1.1 1.7 1.7 0.6
Tinnitus: Yes, now most or all of the time 0.3 0.3 1.2 -0.6 -0.1 0.8 0.6 0.1 -0.8 0.5 -0.2 1.1 0.5 0.6 -0.5 -0.3 0.8 0.5 0.8 0.1
Commuting to job workplace: Public transport 0.6 0.7 2.9 0.4 1.0 0.7 0.1 -0.6 -0.2 -0.9 0.7 -1.3 -0.9 1.0 -0.4 0.2 -1.7 -0.7 -1.1 -0.7
Eye problems/disorders: Glaucoma 1.2 1.4 3.6 0.9 0.5 -0.8 -0.6 -1.9 1.2 -1.2 0.6 -0.4 -1.5 1.2 0.4 -1.1 -1.6 -1.9 -1.3 -1.3
Medication: Blood pressure 0.3 0.5 2.5 -0.5 0.5 1.0 0.1 1.3 -1.6 0.2 -0.6 -0.2 0.7 -0.5 -0.4 1.0 0.4 0.3 0.5 0.4
Pain type(s) experienced in last month: Hip pain 0.2 0.3 1.5 0.3 -0.3 -0.7 -1.2 -0.9 0.2 -0.7 -0.1 -0.4 -0.3 -0.3 -0.5 -0.8 0.1 -0.4 -0.3 0.1
Supplements: Fish oil (including cod liver oil) 0.7 1.0 2.4 1.4 0.6 -0.6 -1.6 -1.4 0.4 -1.1 0.7 -0.9 -1.0 0.6 -0.0 -0.9 -1.2 -0.8 -1.2 -1.0
High cholesterol (Self-reported) 0.6 1.1 2.9 -1.1 -1.7 0.9 1.0 1.0 -0.3 0.8 -1.2 -0.0 1.0 -1.4 -0.6 1.1 1.4 0.7 0.8 1.4
Medication: Bendroflumethiazide 0.4 0.6 1.8 -1.0 0.2 1.4 0.4 1.3 -0.4 0.7 -0.4 0.7 0.9 -0.5 0.8 0.3 1.1 0.4 1.0 0.3
Medication: Paracetamol 0.8 1.3 2.7 1.1 1.6 -1.5 -1.1 -1.2 1.1 0.2 1.4 0.1 -1.1 1.4 1.0 -1.3 -0.6 -0.8 -0.8 -1.6
Medication: Lisinopril 1.2 1.5 3.2 -1.4 -0.7 1.8 0.6 1.2 -1.4 1.7 -1.4 0.3 1.5 -0.3 -1.3 1.7 1.1 1.0 1.4 1.0
Medication: Atorvastatin 0.8 1.0 3.8 -0.2 0.9 0.8 1.6 0.8 -0.5 1.4 -0.3 1.1 1.1 0.8 -0.8 2.0 0.7 0.9 1.3 0.0
Illnesses of father: High blood pressure 0.4 0.5 4.1 -0.5 -0.5 -0.0 -0.2 0.4 -2.0 -0.1 -0.6 -0.7 0.3 -0.7 -1.0 0.1 -0.1 0.6 0.2 0.7
Alcohol drinker status: Never 0.7 0.9 5.4 0.4 0.6 -2.3 -1.6 -0.3 0.3 -0.8 0.1 -0.1 -1.2 -0.1 0.2 -0.9 -1.4 -0.7 -0.9 -0.4
Ever smoked 4.2 7.3 15.0 3.3 2.6 -2.9 -1.6 -2.7 2.1 -2.0 3.9 -2.1 -3.2 2.0 1.5 -2.6 -3.2 -2.9 -3.2 -3.0
Basal metabolic rate 0.3 1.6 10.0 1.4 2.1 -0.8 -0.2 -1.1 0.4 -0.6 1.6 1.4 -0.3 3.2 -0.5 0.1 -0.0 -0.3 0.1 -1.8
Leg fat percentage (left) 2.3 8.3 16.4 -3.3 -1.1 3.1 2.9 3.6 -0.1 3.9 -2.9 3.1 3.7 -0.3 0.8 2.6 3.7 3.0 4.0 2.1
Arm fat-free mass (left) 0.6 2.9 8.6 2.3 2.4 -1.5 -0.9 -2.1 0.6 -1.6 2.4 0.8 -1.5 2.9 -0.5 -1.2 -0.9 -1.4 -1.0 -2.5
Number of operations (self-reported) 0.2 0.3 1.1 -0.2 -1.0 0.0 1.1 -0.6 0.5 0.2 -0.5 -0.3 -0.1 -0.9 0.1 -0.7 0.1 -0.4 -0.0 0.5
Average weekly beer plus cider intake 0.4 0.5 1.9 -0.9 -0.8 1.3 0.6 0.2 -0.2 0.1 -1.4 0.9 0.5 0.3 -0.4 0.9 0.9 0.3 0.7 0.2
Irritability 0.3 0.4 1.1 -1.0 -0.9 1.1 0.6 0.7 -0.1 0.3 -0.4 0.2 0.7 -0.0 -0.2 0.7 0.6 1.0 0.6 0.8
Risk taking 0.2 0.3 0.9 -0.7 -0.6 0.7 0.1 0.7 -0.7 -0.6 -0.4 0.1 0.4 -0.9 0.3 -0.4 0.5 0.5 0.4 0.5
Ever had prostate specific antigen (PSA) test 2.9 3.3 6.3 2.4 1.7 -1.3 -1.0 -2.2 -0.4 -2.3 2.4 -2.1 -2.0 1.0 -0.6 -1.7 -2.5 -1.6 -2.3 -1.6
Fractured/broken bones in last 5 years 0.1 0.2 0.5 0.7 0.1 -0.6 -0.1 -0.4 -0.2 0.2 0.4 0.0 -0.6 0.2 -0.4 -0.1 -0.4 -0.6 -0.5 -0.2
Age started oral contraceptive pill 0.5 0.6 3.5 -0.4 0.8 -0.0 -0.2 0.6 -0.8 0.2 -0.2 1.9 0.5 1.4 -0.9 -0.1 0.2 0.9 1.0 -0.0
Diastolic blood pressure, automated reading 1.0 3.2 8.1 1.6 1.7 -2.8 -1.6 -1.0 0.4 -2.7 2.0 -1.0 -2.1 -0.2 1.8 -2.3 -1.8 -1.5 -2.0 -1.8
Ever depressed for a whole week 2.5 3.1 7.2 1.5 1.6 -1.4 -2.0 -1.7 1.1 -2.3 2.7 0.1 -1.9 2.2 1.3 -1.6 -1.6 -1.4 -1.6 -2.2
Unable to work because of sickness or disability 0.5 0.6 2.0 -0.8 -0.3 1.3 0.6 0.7 -0.4 1.0 -1.4 -0.2 0.6 -1.4 0.9 0.1 0.6 -0.1 0.8 0.6
Commuting to job workplace: Cycle 0.5 0.6 2.7 0.8 -0.2 -1.4 -1.1 -1.1 -0.6 -1.6 0.7 -0.4 -0.6 0.5 -0.4 -0.4 -0.6 -0.3 -0.7 -0.2
Myopia 0.7 1.1 3.1 -0.7 -0.2 0.3 0.5 1.4 -0.2 1.1 -0.3 0.5 1.4 -1.8 1.1 0.7 1.7 1.3 1.1 1.1
Vascular/heart problems diagnosed by doctor 0.5 1.5 7.9 -0.7 -0.7 1.6 2.8 0.5 0.9 2.4 -0.3 1.2 0.8 0.8 0.2 0.1 1.1 1.0 1.0 0.4
Cholesterol lowering medication 1.3 1.9 4.1 -1.2 -0.3 1.3 0.6 2.0 -1.8 1.4 -1.7 1.3 1.4 -1.1 -0.3 1.5 1.7 1.2 1.6 1.1
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 1.8 0.1 0.4 -0.2 0.9 0.6 -0.2 1.3 0.6 -0.0 0.2 0.5 0.5 1.2 0.1 0.0 0.2 -0.4
Pain experienced in last month 1.1 1.8 4.5 1.7 1.5 -1.4 -0.8 -1.3 -0.9 -1.2 1.3 -1.1 -1.6 0.2 -1.4 -0.8 -2.1 -1.3 -1.8 -1.0
Supplements: Calcium 3.1 3.4 6.3 2.4 2.2 -1.9 -1.4 -2.1 0.8 -1.1 2.5 -1.6 -2.2 1.0 0.4 -1.7 -2.1 -2.1 -2.3 -2.1
Basal cell carcinoma (self-reported) 4.6 5.5 12.6 -2.6 -1.4 3.5 2.2 2.3 -1.9 1.9 -2.3 2.0 2.4 -0.3 -2.1 2.8 2.4 2.9 2.7 2.3
Heart attack/myocardial infarction (self-reported) 0.2 0.2 0.7 -0.3 -0.3 0.7 0.3 0.4 0.1 0.7 0.5 -0.0 0.4 -0.6 0.5 0.8 0.7 0.2 0.3 0.2
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 8.1 -0.3 -0.8 1.0 0.8 -0.4 -2.1 -0.8 -0.4 -0.3 -0.1 0.5 -2.9 0.3 -0.5 0.3 -0.3 0.4
Heart disease (siblings) 0.6 0.8 2.8 -0.9 -0.7 0.6 0.7 0.9 -1.2 -0.1 -0.8 1.7 0.5 -0.8 -1.0 -0.1 1.1 0.6 1.1 0.9
Alcohol drinker status: Previous 0.2 0.2 0.8 -0.4 0.2 0.1 -0.4 0.4 -0.8 -0.6 -0.3 0.9 -0.3 0.5 -0.4 0.0 -0.0 -0.3 0.1 -0.4
Pack years of smoking 0.3 0.5 2.2 0.3 1.3 0.3 -0.2 0.6 -1.4 -0.2 0.2 1.5 -0.2 0.7 -0.6 -0.5 -0.1 -0.3 0.4 -0.8
Impedance of whole body 0.2 1.0 3.6 -1.1 -0.7 1.4 0.9 1.4 0.6 0.5 -0.6 -0.4 0.7 -1.7 1.9 0.8 0.3 0.9 0.4 0.8
Leg fat mass (left) 1.7 6.6 14.9 -2.7 -0.3 2.6 2.3 3.0 -0.4 3.5 -2.2 3.5 3.4 1.0 0.3 2.4 3.5 2.8 3.9 1.2
Arm predicted mass (left) 0.6 3.2 8.6 2.4 2.5 -1.6 -0.7 -2.2 1.0 -1.6 2.6 0.7 -1.6 2.9 -0.3 -1.3 -1.0 -1.4 -1.1 -2.6