TWAS hub - KCNG3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.0767	0.0360	0.0034	0.01	0.020	0.002	0.023	0.004	1.6e-02	0.0011	1.9e-01	0.00046	9.2e-02
2	TCGA	Breast Invasive Carcinoma	0.0349	0.0181	0.0018	0.02	0.016	0.019	NA	0.020	4.9e-05	0.0002	5.6e-05	NA	4.8e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Supplements: Calcium	6.3	7.0	9.9	3.2	-2.0
Body Mass Index (BMI) (2010)	6.0	8.2	13.8	-1.6	3.7
Average weekly spirits intake	5.9	7.4	9.9	2.2	-3.1
Diverticular disease/diverticulitis (self-reported)	5.9	7.0	9.5	2.1	-3.1
Lung FEV1/FVC ratio	5.8	29.4	33.5	5.0	-5.8
Medication: Ibuprofen (e.g. Nurofen)	5.3	6.7	9.7	3.1	-1.9
Schizophrenia vs Biploar Disorder	5.0	6.6	8.2	-2.9	2.2
Medication: Ibuprofen	4.9	5.9	8.9	3.0	-1.7
Lung cancer (father)	4.6	5.4	10.2	-3.2	0.7
Glaucoma (self-reported)	4.3	5.0	5.3	2.3	-2.2
Trunk fat percentage	4.2	16.8	26.4	-2.7	5.1
Illness, injury, bereavement, stress in last 2 years	4.2	5.1	10.2	3.2	-0.2
Arm fat percentage (left)	4.2	16.6	25.6	-2.7	5.1
Systolic Blood Pressure	4.1	20.3	27.9	-5.3	-3.6
Basal cell carcinoma (self-reported)	4.0	4.8	8.8	-0.9	3.0
Alcohol usually taken with meals	3.8	6.2	12.1	-0.6	-3.5
Impedance of arm (left)	3.8	17.6	29.4	-5.4	2.4
Body fat percentage	3.8	14.9	23.2	-2.6	4.8
Mineral and other dietary supplements	3.8	5.1	10.0	-3.2	-0.4
Arm fat percentage (right)	3.6	14.4	22.0	-2.6	4.7
Major Depression (MDD)	3.5	4.2	6.2	-2.5	1.5
Impedance of arm (right)	3.5	16.5	28.0	-5.3	2.2
Number of children fathered	3.5	3.9	6.2	1.3	-2.5
Alcohol intake frequency.	3.5	8.1	12.5	-1.9	3.5
Crohns Disease (2017)	3.4	7.5	15.0	-3.9	0.2
Reaction Time	3.4	6.4	6.8	-2.6	2.5
Prostate Cancer	3.4	4.8	9.4	-0.5	-3.1
Medication: Metformin	3.4	4.8	6.0	-1.9	2.5
Medication: Aspirin	3.4	4.5	4.7	-2.1	2.2
Comparative body size at age 10	3.3	9.0	13.7	-2.1	3.7
Fasting Glucose	3.2	3.8	6.4	1.1	-2.5
Overall health rating	3.2	6.9	9.6	-2.1	3.1
Ever had prostate specific antigen (PSA) test	3.2	3.7	4.4	2.1	-1.7
Diabetes diagnosed by doctor	2.9	4.7	8.2	-1.1	2.9
Diastolic blood pressure, automated reading	2.9	8.9	13.7	-3.7	-2.0
Primary Biliary Cirrhosis	2.8	4.0	4.6	2.1	-1.9
Peak expiratory flow (PEF)	2.8	6.6	7.8	2.8	-2.3
Pack years of smoking	2.8	4.1	6.4	-2.5	1.3
Commuting to job workplace: Cycle	2.7	3.2	4.5	-2.1	-1.4
Pack years adult smoking proportion	2.6	3.9	6.9	-2.6	1.0
Supplements: Glucosamine	2.6	3.4	4.3	2.1	-1.6
Hayfever/allergic rhinitis (self-reported)	2.6	3.5	5.3	1.3	-2.3
Medication: Aspirin	2.6	3.3	3.8	-1.7	2.0
Ever had hysterectomy (womb removed)	2.5	2.8	4.6	-2.1	-1.0
Illnesses of mother	2.5	3.1	3.6	1.9	-1.6
Health satisfaction	2.5	3.3	4.4	-1.5	2.1
Wears glasses or contact lenses	2.5	2.8	4.3	2.1	-1.2
Ever smoked	2.5	4.4	8.5	0.5	-2.9
Hand grip strength (left)	2.4	6.4	8.4	2.9	-2.1
Fed-up feelings	2.4	4.4	6.2	-1.6	2.5
Trunk fat mass	2.4	10.5	19.5	-1.2	4.4
Frequency of tiredness / lethargy in last 2 weeks	2.4	3.9	4.9	-1.7	2.2
Leg fat percentage (right)	2.4	8.7	14.1	-1.8	3.8
Cholesterol lowering medication	2.4	3.5	3.8	-1.8	2.0
Cardiovascular Disease	2.3	7.5	14.4	-3.8	-0.8
Bilateral oophorectomy (both ovaries removed)	2.3	2.7	4.9	-2.2	0.7
Illnesses of siblings	2.3	3.2	6.3	2.5	-0.4
Length of working week for main job	2.3	2.5	2.9	-1.7	1.5
Whole body fat mass	2.3	9.6	18.2	-1.0	4.3
Leg fat percentage (left)	2.3	8.4	14.8	-1.4	3.9
Hand grip strength (right)	2.2	5.9	8.1	2.8	-1.9
Falls in the last year	2.2	2.9	4.8	-2.2	1.1
Vascular/heart problems diagnosed by doctor	2.2	5.9	10.9	3.3	1.0
Eye problems/disorders: Diabetes related eye disease	2.1	2.4	4.1	0.8	2.0
High blood pressure	2.1	6.0	8.8	-3.0	-1.8
Had menopause	2.1	2.7	3.3	-1.8	1.4
Heel bone mineral density (BMD) T-score, automated (right)	2.1	4.8	7.1	-2.7	1.6
Trunk fat-free mass	2.1	12.2	22.3	4.7	-1.5
Prospective memory result	2.1	2.5	4.8	2.2	0.5
Trunk predicted mass	2.1	12.1	22.1	4.7	-1.5
Loneliness, isolation	2.1	2.8	5.4	-2.3	0.5
Friendships satisfaction	2.1	2.5	3.0	-1.5	1.7
Arm fat mass (left)	2.1	8.8	16.5	-1.1	4.1
Leg fat mass (left)	2.1	8.0	15.9	-0.3	4.0
Arm fat mass (right)	2.0	8.3	15.9	-0.8	4.0
Medication: Paracetamol	2.0	3.3	6.6	2.6	-0.0
Arm fat-free mass (right)	2.0	10.4	20.6	4.5	-0.5
Smoking status: Previous	2.0	3.0	5.0	1.1	-2.2
Systolic blood pressure, automated reading	1.9	5.6	9.1	-3.0	-1.5
Diabetes (self-reported)	1.9	2.9	4.1	-1.3	2.0
Forced expiratory volume in 1-second (FEV1)	1.9	6.5	10.6	3.3	-1.6
Ever highly irritable/argumentative for 2 days	1.9	2.2	3.5	-1.9	1.0
Leg fat mass (right)	1.9	7.5	14.6	-0.6	3.8
Type 2 Diabetes (T2D) (2018)	1.8	3.4	4.8	-1.4	2.2
Medication: Ramipril	1.8	2.4	4.7	-0.2	-2.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.8	8.8	3.0	-1.7
Arm predicted mass (right)	1.8	9.3	18.5	4.3	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	3.0	1.7	-1.0
Medication: Lisinopril	1.8	2.3	4.6	-0.3	2.1
Alcohol drinker status: Previous	1.8	2.0	2.4	-1.3	1.6
Impedance of whole body	1.8	8.9	17.2	-4.2	0.8
Waist Hip Ratio (WHR)	1.7	7.8	14.1	-3.8	1.2
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	3.6	0.9	1.9
Severe depression (siblings)	1.7	1.9	3.0	0.9	1.7
Serious illness, injury or assault to yourself	1.7	2.0	2.5	1.2	-1.6
Nervous feelings	1.7	3.2	4.6	-1.3	2.1
Exposure to tobacco smoke outside home	1.7	2.3	3.7	-1.9	0.9
Back pain experienced in last month	1.7	2.5	4.4	0.8	2.1
Supplements: Fish oil (including cod liver oil)	1.7	2.3	3.9	2.0	0.8
Arm fat-free mass (left)	1.7	8.4	16.7	4.1	-0.4
Risk taking	1.7	2.4	4.1	-2.0	-0.9
Ever depressed for a whole week	1.7	2.1	3.8	-0.6	-2.0
Arm predicted mass (left)	1.7	8.7	17.1	4.1	-0.6
Irritable Bowel Disease (IBD)	1.6	3.7	7.2	-2.7	-0.5
Rheumatoid Arthritis	1.6	2.3	2.5	1.4	-1.6
Body mass index (BMI)	1.6	6.8	13.4	-0.4	3.7
Financial difficulties in last 2 years	1.6	2.1	4.1	-2.0	0.3
Depression (self-reported)	1.6	2.0	2.3	-1.5	1.3
Breastfed as a baby	1.6	1.9	3.8	0.3	-1.9
Birth weight	1.6	3.6	7.0	0.3	2.6
Mean time to correctly identify matches	1.6	3.1	4.0	-2.0	1.5
Family relationship satisfaction	1.6	2.0	2.6	-1.1	1.6
Average weekly red wine intake	1.6	2.3	3.5	1.1	-1.9
Long-standing illness, disability or infirmity	1.6	2.5	5.0	0.2	2.2
Osteoporosis (self-reported)	1.6	2.0	3.8	1.9	-0.5
Heart disease (siblings)	1.6	1.9	3.8	-0.2	1.9
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.5	5.5	-2.4	1.2
Waist circumference	1.5	5.6	10.2	-1.0	3.2
Neck or shoulder pain in last month	1.5	2.2	3.9	-0.6	2.0
Knee pain experienced in last month	1.5	2.3	4.5	-0.0	2.1
Ever had bowel cancer screening	1.5	1.8	3.5	1.9	-0.3
Schizophrenia (2014)	1.4	3.1	3.3	-1.8	-1.7
BMI	1.4	8.2	16.3	0.2	4.0
Past tobacco smoking	1.4	2.6	4.0	-1.1	2.0
Medication: Lansoprazole	1.4	1.6	2.1	1.5	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	3.0	-1.7	1.1
High blood pressure (siblings)	1.4	2.0	3.8	-2.0	0.3
Whole body fat-free mass	1.4	8.1	16.2	4.0	-0.2
Whole body water mass	1.4	8.1	16.1	4.0	-0.3
Miserableness	1.4	2.5	3.2	-1.4	1.8
Schizophrenia (2018)	1.3	2.7	3.8	-2.0	-1.3
Allergy or Eczema	1.3	3.4	6.0	0.9	-2.4
Diabetes (mother)	1.3	1.7	2.0	1.2	-1.4
Pulse wave reflection index	1.3	1.7	3.3	0.2	-1.8
Suffer from ‘nerves’	1.3	2.0	3.6	-0.6	1.9
Hypertension (Self-reported)	1.3	3.5	4.5	-2.1	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	5.2	2.3	-0.4
Financial situation satisfaction	1.3	1.6	2.2	-1.5	1.0
Eye problems/disorders: Glaucoma	1.3	1.5	1.9	1.1	-1.4
Frequency of depressed mood in last 2 weeks	1.2	1.6	2.1	-1.1	1.5
Ever used hormone-replacement therapy (HRT)	1.2	1.6	2.3	-0.9	1.5
Townsend deprivation index at recruitment	1.2	1.8	2.3	-1.5	1.1
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	2.1	-1.2	1.5
Allergy	1.2	2.6	4.9	-0.6	2.2
Medication: Simvastatin	1.2	1.7	2.0	-1.4	1.2
Medication: Omeprazole	1.2	1.4	1.9	1.0	1.4
Had major operations	1.2	1.4	1.8	1.3	-1.0
Medication for cholesterol	1.2	1.8	3.3	1.8	-0.5
Medication: Paracetamol	1.2	1.9	3.7	1.9	-0.3
Pain experienced in last month	1.2	2.1	3.6	-0.7	-1.9
Triglycerides	1.1	1.8	3.0	-0.7	1.7
Blood Eosinophil Count	1.1	8.7	16.8	-4.1	0.7
Maternal smoking around birth	1.1	1.5	2.7	0.6	-1.6
Hayfever, allergic rhinitis or eczema	1.1	2.3	4.3	0.5	-2.1
Hair/balding pattern: Pattern 2	1.1	1.4	2.1	0.8	-1.4
Fluid intelligence score	1.1	2.4	4.6	-2.1	-0.3
Pulse wave Arterial Stiffness index	1.1	1.3	1.6	1.0	-1.3
Emphysema/chronic bronchitis	1.1	1.2	1.9	1.4	-0.7
Illnesses of father: Heart disease	1.1	1.5	2.9	1.7	-0.2
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	3.0	0.6	1.7
Breast cancer (self-reported)	1.1	1.4	2.7	0.1	1.6
Medication: Blood pressure	1.1	2.1	4.0	-2.0	0.3
Number of operations (self-reported)	1.1	1.7	2.6	0.9	-1.6
Age started oral contraceptive pill	1.1	1.4	2.4	-0.6	1.5
Depression (Nagel 2018)	1.0	1.4	2.0	-0.9	1.4
Vitamin and mineral supplements	1.0	1.3	2.5	-1.6	0.4
Supplements: Zinc	1.0	1.1	1.6	0.7	-1.3
Number of incorrect matches in round	1.0	1.7	2.1	1.1	-1.4
Mouth/teeth dental problems	1.0	1.5	2.4	0.7	-1.6
Neuroticism score	1.0	2.2	2.6	-1.3	1.6
Weight	1.0	5.0	9.3	0.9	3.1
Hip circumference	1.0	4.3	7.8	0.9	2.8
Medication for pain relief, constipation, heartburn	1.0	1.7	3.4	-1.8	-0.1
Comparative height size at age 10	1.0	5.6	8.7	3.0	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	3.3	0.9	-1.8
Basal metabolic rate	1.0	5.3	10.2	3.2	0.7
Hearing difficulty/problems: Yes	0.9	1.4	2.5	0.6	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.3	2.2	-0.5	1.5
Multivitamins +/- minerals	0.9	1.1	2.1	0.3	-1.5
High blood pressure (mother)	0.9	1.3	2.6	-1.6	-0.0
Exposure to tobacco smoke at home	0.9	1.0	1.0	1.0	-1.0
Tense / ‘highly strung’	0.9	1.4	2.8	-0.2	1.7
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.1	-1.4	0.6
Worry too long after embarrassment	0.9	1.5	1.7	-1.3	1.1
Wheeze or whistling in the chest in last year	0.9	1.6	2.9	-1.7	0.5
Pulse wave peak to peak time	0.9	1.0	1.2	-0.9	1.1
Medication: Blood pressure	0.9	1.7	3.3	-1.8	-0.2
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.5	1.2	0.8
Leg fat-free mass (right)	0.9	4.7	6.7	2.6	1.7
Osteoarthritis (self-reported)	0.9	1.2	2.0	1.4	0.6
Leg predicted mass (right)	0.9	4.7	6.7	2.6	1.6
Hearing aid user	0.9	1.0	1.1	1.0	1.0
Fractured/broken bones in last 5 years	0.9	1.2	2.0	1.4	-0.6
Alzheimer’s Disease (in mother)	0.8	1.0	1.5	-0.7	1.2
HDL Cholesterol	0.8	1.3	1.4	1.2	-1.1
Smoking Status	0.8	2.0	3.6	0.6	-1.9
Leg predicted mass (left)	0.8	4.0	5.0	2.2	1.7
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.6	-1.3	-0.7
Pulse rate	0.8	1.4	2.8	1.7	0.1
Blood clot in the leg (DVT)	0.8	1.0	1.8	1.4	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.9	-0.1	-1.4
Pulse rate, automated reading	0.8	2.5	3.2	1.3	1.8
Number of full sisters	0.8	0.9	1.9	-1.4	0.1
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.1	0.9	1.0
Average weekly beer plus cider intake	0.8	1.1	2.2	-0.2	1.5
Irritability	0.8	1.4	2.4	-1.5	0.7
Bipolar Disorder or Schizophrenia	0.7	1.8	2.2	-1.5	-1.2
Neuroticism (Nagel 2018)	0.7	1.6	1.7	-1.3	1.2
Ovarian Cancer	0.7	0.9	1.4	-0.6	1.2
Impedance of leg (right)	0.7	3.4	5.9	-2.4	-1.0
Leg fat-free mass (left)	0.7	3.6	4.2	2.0	1.8
Relative age voice broke	0.7	1.0	2.0	-0.2	-1.4
Medication: Atenolol	0.7	0.9	1.3	-0.7	1.1
Happiness	0.7	0.8	1.6	-0.2	1.3
Hair/balding pattern: Pattern 4	0.7	1.7	2.2	-1.1	1.5
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.3	1.5	-0.2
Heart disease (mother)	0.7	0.9	1.4	-0.5	1.2
Illnesses of father: None of the above (group 1)	0.7	0.9	1.7	-1.3	0.1
Lupus	0.6	0.9	1.6	-1.3	-0.4
Blood Platelet Count	0.6	6.4	9.9	3.1	1.7
Height	0.6	12.3	24.6	5.0	-0.2
Diabetes (father)	0.6	0.7	1.4	1.2	0.1
Average weekly fortified wine intake	0.6	0.7	1.4	0.3	-1.2
Taking other prescription medications	0.6	0.9	1.3	-0.7	1.2
Qualifications: CSEs or equivalent	0.6	0.8	1.0	1.0	-0.8
Forced vital capacity (FVC)	0.6	2.2	4.5	2.1	0.1
Alcohol intake versus 10 years previously	0.6	0.9	1.6	-0.4	1.2
Standing height	0.6	6.0	10.8	3.3	-1.1
Forced vital capacity (FVC), Best measure	0.6	2.1	3.3	1.8	-1.0
Qualifications: nursing, teaching	0.6	1.0	1.9	1.4	0.2
Commuting to job workplace: Public transport	0.6	0.7	1.1	-0.6	-1.0
Medication: Bendroflumethiazide	0.6	0.8	0.9	-0.9	1.0
Crohns Disease (2012)	0.5	0.8	1.6	-1.3	0.2
Relative age of first facial hair	0.5	1.1	2.1	-1.5	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.1	-1.1	0.3
Medication: Cholesterol lowering	0.5	0.7	1.3	-0.4	1.1
Birth weight of first child	0.5	0.8	1.0	-1.0	0.8
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.4	1.2	0.5
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	0.8	-0.9	-0.7
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	1.8	1.3	0.3
Medication: Amlodipine	0.5	0.7	0.8	-0.8	-0.9
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.3	1.1	0.0
Qualifications: College or University degree	0.5	1.7	2.5	1.0	-1.6
Chest pain or discomfort	0.5	0.8	1.5	-1.2	0.1
Mood swings	0.5	0.9	1.6	0.4	1.3
Commuting to job workplace: Walk	0.5	0.6	1.0	0.4	-1.0
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.1	1.0	-0.4
Medication: Atorvastatin	0.5	0.6	1.1	-0.3	1.0
Illnesses of father: High blood pressure	0.5	0.6	1.0	-1.0	-0.4
Unable to work because of sickness or disability	0.5	0.7	1.0	-0.6	1.0
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	0.7	0.8	0.7
Depressed Affect (Nagel 2018)	0.4	0.9	1.2	-0.8	1.1
Breast Cancer	0.4	1.1	1.3	-0.9	-1.2
Bipolar Disorder (2011)	0.4	0.4	0.8	-0.0	-0.9
HbA1C	0.4	0.5	0.7	0.5	-0.8
LDL Cholesterol	0.4	0.6	0.8	-0.9	0.6
Neuroticism (2016)	0.4	0.6	1.2	-0.3	1.1
Blood White Count	0.4	2.7	2.9	-1.7	-1.6
Heel T-Score	0.4	3.5	7.1	-2.7	-0.0
Hypothyroidism (self reported)	0.4	0.9	1.3	1.1	-0.7
Neuroticism	0.4	1.1	1.9	-0.5	1.4
Chronotype (morning person)	0.4	0.9	1.7	0.1	-1.3
Tanning	0.4	5.1	10.2	-0.2	-3.2
Chronic bronchitis/emphysema (father)	0.4	0.5	0.9	0.3	1.0
Impedance of leg (left)	0.4	2.2	3.8	-1.9	-0.8
Loud music exposure frequency	0.4	0.4	0.7	0.8	0.4
Shortness of breath walking on level ground	0.4	0.5	0.9	-0.9	0.4
Eye problems/disorders: None of the above	0.4	0.4	0.6	-0.5	-0.8
Age at last live birth	0.4	0.6	1.1	-0.1	-1.1
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.6	0.8	0.6
Medication: Gliclazide	0.4	0.4	0.8	-0.9	0.2
Smoking status: Current	0.4	0.6	1.1	-1.1	-0.2
Myopia	0.4	0.6	0.8	-0.6	0.9
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.0	1.0	-0.2
Worry (Nagel 2018)	0.3	0.6	1.1	-0.3	1.0
Alzheimer’s Disease (including proxy)	0.3	0.5	0.8	0.4	-0.9
Verbal and Numeric Reasoning (VNR)	0.3	0.6	0.8	-0.9	-0.7
Mean Putamen Volume	0.3	0.3	0.6	-0.8	-0.1
Ulcerative Colitis	0.3	0.5	0.9	-0.3	-0.9
Blood Red Count	0.3	3.1	4.4	-2.1	1.4
Current tobacco smoking	0.3	0.5	0.5	-0.7	-0.7
Heart attack	0.3	0.4	0.5	-0.6	0.7
Father’s age at death	0.3	0.4	0.5	0.6	-0.7
Hair/balding pattern: Pattern 3	0.3	0.5	0.8	-0.5	0.9
Noisy workplace	0.3	0.3	0.6	0.8	0.2
Illnesses of siblings: Diabetes	0.3	0.4	0.7	-0.8	0.1
Average weekly champagne plus white wine intake	0.3	0.5	0.6	0.6	-0.8
Ever taken oral contraceptive pill	0.3	0.3	0.6	0.2	-0.8
Mother’s age at death	0.3	0.3	0.6	0.8	0.2
High cholesterol (Self-reported)	0.3	0.6	1.1	0.3	1.0
Alcohol drinker status: Never	0.3	0.3	0.3	-0.6	-0.5
Alzheimer’s Disease (in father)	0.2	0.2	0.5	0.1	-0.7
Ulcerative Colitis (UC)	0.2	0.4	0.8	-0.9	-0.2
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.3	0.4	0.6
Lung FVC	0.2	0.8	1.5	1.2	0.2
Medication for hormone replacement therapy	0.2	0.2	0.3	0.2	-0.6
Medication: Co-codamol	0.2	0.3	0.5	-0.7	0.3
Stomach or abdominal pain in last month	0.2	0.2	0.4	0.2	0.6
Medication: Levothyroxine sodium	0.2	0.4	0.7	0.8	-0.2
Sitting height	0.2	1.6	2.6	1.6	0.9
Qualifications: None of the above	0.2	0.4	0.6	-0.8	0.4
Pain all over the body in last month	0.2	0.2	0.4	-0.1	-0.7
Worrier / anxious feelings	0.2	0.4	0.4	0.6	0.6
Mouth/teeth dental problems: Dentures	0.2	0.4	0.8	0.1	0.9
Number of full brothers	0.2	0.2	0.3	0.4	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.3	-0.4	-0.6
Eye problems/disorders: Cataract	0.2	0.3	0.3	0.5	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.3	0.4	-0.5
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.3	-0.3	0.6
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.5	0.7	-0.3
Hair Pigment	0.1	2.9	4.8	2.2	-0.9
Number of treatments/medications taken	0.1	0.2	0.3	0.5	-0.4
Sensitivity / hurt feelings	0.1	0.2	0.5	-0.7	0.2
Angina	0.1	0.1	0.2	0.2	0.4
Hearing difficulty/problems with background noise	0.1	0.2	0.3	0.2	0.5
Had other major operations	0.1	0.2	0.2	-0.3	-0.5
Time employed in main current job	0.1	0.1	0.2	-0.0	-0.4
Number of live births	0.1	0.2	0.2	-0.3	-0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.2	-0.3	0.4
Headache pain in last month	0.1	0.1	0.2	-0.3	0.4
Gout (self-reported)	0.1	0.2	0.3	0.6	0.1
Age at first live birth	0.1	0.2	0.4	0.1	-0.6
Angina (self-reported)	0.1	0.1	0.1	0.3	0.2
Migraine (self-reported)	0.1	0.1	0.3	0.0	-0.5
Medication: Seretide 50 evohaler	0.1	0.1	0.3	-0.5	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.4	0.2
Supplements: Vitamin C	0.1	0.1	0.1	0.3	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.5	0.2
Guilty feelings	0.1	0.2	0.3	-0.5	-0.3
Bipolar Disorder (2018)	0.0	0.1	0.1	0.0	-0.4
Age at First Birth	0.0	0.0	0.0	0.1	-0.2
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.1	-0.1
Respiratory disease	0.0	0.0	0.0	0.2	-0.1
Age when periods started (menarche)	0.0	0.1	0.2	-0.1	-0.4
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.0	-0.1	-0.1
Asthma	0.0	0.1	0.1	-0.3	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.0	0.1	0.1
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.1	0.1	0.2
Medication: Allopurinol	0.0	0.1	0.1	0.3	0.2
Leg pain on walking	0.0	0.0	0.0	-0.1	0.2
Asthma (self-reported)	0.0	0.0	0.1	-0.1	-0.3
Number of self-reported non-cancer illnesses	0.0	0.0	0.0	-0.2	0.1

Hub : Genes

KCNG3

Models

Trait associations