Hub : Genes

WIPF1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2970	0.0460	0.0e+00	0.282	0.263	0.294	0.282	0.289	2.1e-34	7.2e-32	4.3e-36	2.1e-34	1.8e-35
2	GTEx	Adipose Subcutaneous	0.0890	0.0360	4.8e-03	0.038	NA	0.026	NA	0.036	4.4e-04	NA	3.1e-03	NA	6.1e-04
3	GTEx	Brain Cerebellum	0.5020	0.1010	3.3e-05	0.049	NA	0.061	NA	0.106	1.5e-02	NA	6.9e-03	NA	4.8e-04
4	GTEx	Brain Cortex	0.2340	0.0830	8.2e-04	0.163	NA	0.182	NA	0.147	3.0e-05	NA	9.9e-06	NA	7.6e-05
5	GTEx	Brain Hippocampus	0.2338	0.1043	9.9e-03	0.002	NA	0.024	NA	0.008	2.9e-01	NA	9.2e-02	NA	2.0e-01
6	GTEx	Cells Transformed fibroblasts	0.1370	0.0450	1.5e-04	0.044	NA	0.046	NA	0.050	2.8e-04	NA	2.1e-04	NA	1.3e-04
7	GTEx	Testis	0.3180	0.1020	3.4e-03	0.131	NA	0.120	NA	0.115	2.0e-06	NA	5.9e-06	NA	9.2e-06
8	GTEx	Thyroid	0.1060	0.0400	1.3e-03	0.096	NA	0.066	NA	0.092	8.9e-08	NA	8.5e-06	NA	1.6e-07
9	ROSMAP	Brain Pre-frontal Cortex	0.0948	0.0268	2.0e-06	0.076	0.031	0.079	0.043	0.047	4.7e-10	5.9e-05	2.1e-10	2.6e-06	8.9e-07
10	YFS	Blood	0.1918	0.0296	0.0e+00	0.160	0.185	0.194	0.184	0.190	6.6e-50	4.3e-58	2.4e-61	4.7e-58	4.8e-60
11	TCGA	Brain Lower Grade Glioma	0.0805	0.0299	2.8e-08	0.090	0.082	0.088	NA	0.090	1.9e-10	1.5e-09	3.3e-10	NA	2.1e-10

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	3.0	4.8	6.7	-2.5	1.0	-2.4	-2.2	-2.6	2.4	-1.4	2.0	-2.5	1.9	-2.4
Bipolar Disorder or Schizophrenia	0.7	1.8	8.8	-0.0	2.1	-0.4	-0.9	-0.5	1.8	-3.0	1.0	-0.2	0.9	-0.1
Depressed Affect (Nagel 2018)	0.5	1.1	4.2	-0.6	1.8	-0.5	0.2	-0.3	1.2	1.0	2.0	-0.3	0.9	-0.7
Depression (Nagel 2018)	0.4	0.6	2.7	-0.0	1.7	0.2	0.6	0.1	0.2	-0.6	1.6	0.1	0.9	0.1
Intelligence (Savage-Jansen 2018)	1.7	5.3	13.2	-3.6	0.3	-2.9	-0.3	-3.1	1.6	-0.1	1.8	-3.1	2.3	-2.5
Neuroticism (Nagel 2018)	0.6	1.3	4.0	0.7	2.0	1.3	1.0	1.4	0.5	0.5	1.5	1.2	0.4	0.9
Schizophrenia (2018)	1.1	2.3	7.2	2.0	1.9	1.4	0.6	1.5	0.4	-2.7	-0.3	1.7	-0.4	1.8
Schizophrenia vs Biploar Disorder	1.5	2.0	3.8	1.6	1.7	1.7	1.5	2.0	0.7	0.4	0.2	1.9	0.5	1.8
Worry (Nagel 2018)	0.4	0.8	1.8	0.7	0.7	1.3	1.3	1.3	0.6	-0.4	0.5	1.1	0.5	0.7
Alzheimer’s Disease (in mother)	0.9	1.0	2.9	0.7	1.7	0.6	0.0	1.5	0.1	-1.3	0.7	1.2	0.5	1.3
Alzheimer’s Disease (in father)	0.7	0.8	2.0	0.6	0.9	0.9	0.3	0.3	1.3	0.5	0.7	1.1	0.8	1.4
Alzheimer’s Disease (including proxy)	0.5	0.7	1.5	0.2	1.2	0.3	-0.6	0.5	1.1	-0.4	1.1	0.8	1.1	1.0
Crohns Disease (2017)	2.3	5.0	11.2	-1.8	2.0	-0.4	-2.6	-1.6	3.2	-0.1	3.4	-1.7	3.1	-2.1
Irritable Bowel Disease (IBD)	1.6	3.9	8.0	-1.9	0.9	-1.0	-1.6	-1.8	2.8	0.2	2.5	-1.8	2.7	-2.5
Ulcerative Colitis (UC)	1.3	2.5	6.6	-1.9	-0.7	-1.9	-0.5	-2.0	1.4	-0.4	1.0	-2.0	1.2	-2.6
Major Depression (MDD)	0.5	0.6	2.3	0.4	-0.6	0.7	0.6	0.1	-1.5	-0.2	-1.2	0.4	-1.2	0.5
Reaction Time	1.1	2.0	8.6	-0.2	1.9	1.0	-2.5	-0.5	1.0	2.9	0.9	-0.1	0.9	-0.3
Verbal and Numeric Reasoning (VNR)	0.7	1.8	5.2	-2.3	-0.4	-1.7	0.7	-1.6	-0.1	1.3	0.1	-1.8	0.7	-1.7
Breast Cancer	0.1	0.2	1.1	0.1	-0.1	0.3	0.5	-0.2	-0.4	1.1	0.7	0.1	-0.1	0.3
Ovarian Cancer	1.4	1.9	5.5	-1.6	1.7	-0.8	0.7	-1.6	1.2	-1.0	2.4	-1.2	1.2	-0.8
Prostate Cancer	2.7	3.7	10.5	-2.2	0.7	-1.1	-1.9	-1.9	2.4	0.3	2.5	-1.7	3.2	-1.4
Age at First Birth	0.7	1.0	2.0	1.3	0.3	1.0	0.8	1.4	-0.4	1.1	-0.3	1.4	-0.5	1.4
Bipolar Disorder (2011)	2.4	2.3	7.0	-1.5	-0.8	-1.8	-1.2	-2.1	1.6	-2.6	0.8	-1.9	0.0	0.0
Body Mass Index (BMI) (2010)	0.9	1.2	3.5	1.6	-0.3	0.8	0.1	1.6	0.0	1.9	-0.7	1.5	-0.2	1.0
Coronary Artery Disease (CAD)	2.9	3.5	7.1	-1.9	0.8	-1.7	-2.3	-2.3	1.5	-1.3	1.7	-2.4	0.8	-2.7
Crohns Disease (2012)	1.6	2.5	5.7	-1.7	0.6	-1.1	-1.9	-1.5	1.7	-0.3	1.7	-1.6	1.7	-2.4
Mean Putamen Volume	1.3	1.5	3.9	-2.0	0.4	-0.6	-0.5	-1.0	1.2	-1.1	1.1	-1.6	1.2	-1.6
Fasting Glucose	0.6	0.8	2.6	-1.1	-0.8	-0.3	-0.7	-0.6	0.9	1.6	0.8	-0.7	1.0	-0.1
HbA1C	2.3	2.6	5.2	-1.3	0.2	-1.2	-1.6	-1.8	2.1	-1.0	2.3	-1.5	2.1	-1.4
HDL Cholesterol	0.2	0.3	1.2	-0.5	0.1	-0.9	-0.2	-0.3	-0.4	-1.1	-0.2	-0.6	-0.7	-0.4
LDL Cholesterol	0.6	0.9	2.6	0.6	-0.9	0.1	0.8	0.6	-1.5	0.3	-1.5	0.4	-1.6	0.6
Lupus	0.5	0.7	1.5	0.2	-1.1	1.0	-0.4	0.2	-0.9	1.2	-1.2	0.4	-0.9	0.8
Neuroticism (2016)	0.2	0.2	1.5	0.0	0.6	0.7	1.2	0.1	0.0	-0.3	0.2	0.3	-0.0	0.0
Primary Biliary Cirrhosis	0.4	0.5	1.4	-1.0	-0.5	0.0	-1.1	-0.4	-0.6	1.2	-0.9	-0.5	0.2	-0.4
Rheumatoid Arthritis	0.2	0.3	2.2	-0.0	-0.3	0.3	-0.6	-0.2	-0.4	1.5	-0.2	0.4	-0.3	0.3
Schizophrenia (2014)	0.9	2.0	4.5	1.8	1.8	1.8	0.8	1.2	0.5	-2.1	-0.4	1.6	-0.2	1.7
Triglycerides	1.5	2.4	4.1	-1.6	0.8	-1.3	-2.0	-1.5	2.0	0.8	1.6	-1.6	1.6	-1.9
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.2	0.4	0.7	-0.3	-0.7	-0.3	0.8	-0.0	1.1	0.2	0.4	-0.2
Ulcerative Colitis	0.4	0.5	2.0	-0.8	-0.9	-0.9	0.9	-0.5	0.1	-0.1	-0.2	-0.8	0.3	-1.4
Blood Eosinophil Count	0.9	7.2	14.7	-3.5	-0.2	-3.8	-2.8	-3.5	1.1	0.4	2.4	-3.6	1.3	-3.2
Blood Platelet Count	0.2	2.8	9.2	-2.1	-0.0	-1.6	-3.0	-1.6	1.5	1.6	1.0	-1.3	1.2	-1.7
Blood Red Count	0.3	3.1	6.2	2.5	0.7	2.5	1.5	2.5	-0.6	0.4	-0.2	2.4	-0.9	2.3
Blood White Count	0.1	0.9	3.6	0.1	1.0	0.7	-1.2	0.7	0.7	0.8	1.9	0.4	1.4	-0.1
Heel T-Score	0.7	5.7	17.6	-1.2	3.0	-0.8	-1.3	-1.9	4.2	-1.4	3.3	-1.6	3.0	-2.0
BMI	1.4	8.2	18.6	-2.6	-1.4	-3.5	-4.3	-3.6	0.9	-2.2	2.1	-3.4	1.1	-3.9
Height	0.0	0.7	1.9	0.4	-1.4	0.5	1.3	0.6	-1.2	-0.8	-0.8	0.1	-0.0	0.7
Waist Hip Ratio (WHR)	1.0	4.4	12.5	1.6	-2.6	1.3	1.1	1.6	-2.6	-0.5	-3.1	1.5	-3.5	1.3
Systolic Blood Pressure	3.6	18.3	40.3	-2.8	4.5	-2.0	-6.1	-4.0	5.3	-0.6	5.4	-3.1	6.3	-2.7
Smoking Status	1.3	3.1	5.6	1.8	-0.3	2.1	2.3	2.4	-1.8	-0.3	-1.9	1.9	-1.4	1.8
Allergy or Eczema	0.7	1.8	4.1	-2.0	-0.2	-1.7	-1.2	-1.9	0.7	0.2	1.0	-1.6	1.3	-1.4
Cardiovascular Disease	3.8	12.6	25.4	-3.2	2.6	-2.5	-5.0	-3.8	4.3	-1.1	4.3	-3.1	4.5	-2.7
Hypothyroidism (self reported)	0.2	0.4	1.1	0.3	1.1	0.4	-0.8	0.0	1.0	0.1	0.6	0.3	0.8	0.4
Respiratory disease	0.2	0.4	1.8	0.1	-1.3	0.3	-0.2	0.1	-0.9	0.4	-0.8	0.1	-0.7	-0.1
Type 2 Diabetes (T2D) (2018)	0.8	1.5	3.5	-1.6	0.3	-1.9	-1.4	-1.5	1.1	-0.2	1.2	-1.3	0.6	-1.0
Lung FEV1/FVC ratio	1.1	5.6	11.9	2.4	-1.1	2.0	3.5	2.7	-2.2	1.8	-2.1	2.7	-2.4	2.4
Lung FVC	0.4	2.0	8.6	-0.9	2.0	-0.8	-2.9	-0.7	1.2	-0.9	1.6	-0.7	1.6	-0.3
Neuroticism	0.4	0.9	2.4	0.4	1.5	1.0	0.1	0.6	1.1	0.7	1.6	1.1	0.7	0.9
Chronotype (morning person)	0.4	0.9	3.1	0.7	-0.5	0.9	0.8	1.1	-1.0	0.2	-1.3	0.9	-1.8	0.8
Hair Pigment	0.0	1.4	3.0	1.7	-1.0	0.3	0.4	1.0	-1.2	-1.6	-1.7	0.6	-1.6	0.4
Tanning	0.2	2.5	5.6	1.4	-1.2	0.9	1.5	1.5	-1.9	2.4	-1.8	1.2	-1.9	0.8
Hand grip strength (left)	0.2	0.6	2.0	-0.0	-1.4	-0.0	-0.1	0.2	-1.4	0.3	-1.2	-0.0	-0.8	-0.1
Number of treatments/medications taken	1.3	2.4	3.7	-1.9	1.1	-1.8	-1.3	-1.7	1.4	0.8	1.2	-1.6	1.9	-1.8
Average weekly spirits intake	0.6	0.7	2.7	1.0	-1.7	0.6	-0.6	0.9	-0.0	0.7	-0.9	0.9	-0.3	0.8
Sensitivity / hurt feelings	0.8	1.3	2.6	1.3	1.6	1.6	0.1	1.3	-0.3	0.5	0.1	1.5	-1.0	1.5
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.5	0.7	1.6	1.0	1.2	0.8	0.6	0.6	1.2	1.0	1.1	1.1
Hearing difficulty/problems: Yes	0.1	0.2	0.5	0.0	0.1	0.1	0.3	0.4	0.5	0.2	-0.4	0.6	0.3	0.7
Relative age of first facial hair	0.4	0.8	7.1	0.1	0.1	-0.8	-0.9	-0.0	-0.4	-2.7	0.6	-0.1	-0.2	0.3
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.5	-0.8	-0.0	-0.8	-0.2	-0.8	-0.3	-1.2	0.4	-0.9	-0.7	-1.2
Ever used hormone-replacement therapy (HRT)	0.4	0.6	1.8	-0.3	-0.5	-0.7	0.6	-0.3	-0.8	-0.7	-1.1	-0.6	-1.3	-0.8
Ever had hysterectomy (womb removed)	0.2	0.2	0.7	0.2	0.5	0.2	0.1	0.5	0.8	-0.8	0.4	0.3	0.6	-0.1
Systolic blood pressure, automated reading	2.8	8.0	13.1	-2.7	2.3	-2.2	-3.6	-2.9	3.3	-0.3	3.3	-2.9	3.5	-2.5
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.6	0.4	-0.6	0.3	-0.1	0.8	-0.0	-0.1	-0.5	0.2	-0.3	0.0
Angina	1.9	2.4	6.7	-1.7	1.0	-0.8	-0.9	-1.4	2.3	0.4	2.0	-1.2	2.6	-1.3
Medication for hormone replacement therapy	0.9	1.1	2.3	-1.1	-1.2	-1.5	0.4	-1.2	-0.4	-0.5	-0.9	-1.2	-1.1	-1.1
Vitamin and mineral supplements	0.2	0.3	0.8	0.5	-0.6	0.7	0.0	0.2	0.1	-0.9	-0.1	0.7	0.4	0.8
Supplements: Zinc	1.0	1.1	4.5	1.3	2.1	1.0	1.2	1.1	-0.1	-0.1	-0.2	1.2	-0.1	1.0
Medication: Co-codamol	0.4	0.5	3.0	-0.2	-1.7	-0.6	0.2	-0.0	-0.9	-0.5	-0.6	-0.0	-0.7	-0.3
Medication: Metformin	0.5	0.7	2.0	-1.0	-0.1	-0.8	-1.3	-0.5	1.4	-0.1	0.9	-0.6	0.9	-0.4
Diabetes (father)	2.4	2.9	5.6	-2.0	0.9	-1.8	-1.0	-2.0	0.7	-2.1	1.5	-2.4	1.3	-2.1
Diabetes (mother)	1.1	1.4	3.1	-1.2	-0.6	-1.5	-0.3	-1.0	0.1	-1.7	1.2	-1.4	1.0	-1.7
Severe depression (siblings)	1.0	1.1	6.1	0.4	2.5	0.6	0.5	1.2	0.8	-0.3	1.6	0.3	0.9	0.2
Pack years adult smoking proportion	0.3	0.5	1.5	0.4	-0.3	-0.3	-0.5	0.7	-0.8	-0.9	-1.2	-0.0	-1.2	-0.1
Impedance of leg (right)	2.3	11.0	23.2	4.1	2.3	4.5	3.4	4.8	0.3	2.4	-0.6	4.4	-0.2	4.2
Leg fat-free mass (left)	1.4	7.4	13.8	-3.4	-1.8	-3.6	-3.1	-3.6	0.0	-1.7	1.2	-3.7	0.8	-3.4
Trunk fat percentage	0.6	2.4	9.1	-0.4	2.4	-0.6	-1.3	-0.4	1.9	-0.4	3.0	-0.7	1.9	-1.1
Hand grip strength (right)	0.2	0.6	2.8	-0.3	-1.7	-0.5	-0.7	-0.1	-0.9	-0.9	-0.6	-0.5	-0.4	-0.4
Townsend deprivation index at recruitment	0.2	0.3	1.0	0.1	0.8	0.1	-0.2	0.2	-0.5	0.8	-0.3	0.3	-1.0	0.4
Current tobacco smoking	0.7	1.2	5.0	0.1	-0.6	0.3	0.2	0.3	-1.9	-0.4	-1.8	0.2	-2.2	0.4
Average weekly fortified wine intake	0.9	1.0	3.0	-1.2	-0.1	-1.7	0.1	-0.7	-0.3	0.2	-0.6	-1.7	-0.3	-1.7
Maternal smoking around birth	0.5	0.8	3.8	0.6	0.6	0.2	-0.0	1.4	-0.8	-2.0	1.1	0.2	-0.4	-0.1
Fed-up feelings	0.2	0.4	1.6	-0.7	0.4	0.0	-0.3	-0.6	1.0	1.3	0.9	-0.1	-0.1	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	2.3	0.1	1.2	0.4	0.7	0.1	0.6	-0.5	1.5	0.1	0.8	0.1
Relative age voice broke	0.6	0.9	2.5	-0.1	-1.5	-1.0	-0.9	-0.4	-1.6	-0.3	-1.3	-0.0	-1.2	0.2
Taking other prescription medications	1.0	1.6	5.3	-0.8	2.3	-0.4	-1.1	-0.6	0.9	1.3	1.9	-0.4	1.8	-0.4
Age when periods started (menarche)	0.5	1.3	2.7	1.4	-1.0	0.7	0.2	1.2	-1.2	-0.8	-1.5	1.0	-1.6	1.2
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.5	-0.6	0.0	-0.5	-0.9	-0.4	0.8	-1.2	0.6	-0.5	0.5	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.6	8.4	-1.2	2.0	-1.0	-0.4	-1.2	2.9	-1.5	1.8	-1.6	1.6	-1.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.2	0.5	-0.2	0.3	-0.1	0.0	-0.3	-0.7	-0.6	0.1	-0.2	-0.6	-0.3
Qualifications: CSEs or equivalent	2.4	3.2	7.4	2.3	-0.0	2.1	2.6	2.7	0.3	0.0	0.9	2.4	0.4	2.1
Serious illness, injury or assault to yourself	0.4	0.5	1.9	-0.5	0.2	-1.0	-0.8	-0.0	-0.3	-1.4	0.8	-0.7	-0.4	-0.6
High blood pressure	3.9	10.9	21.8	-3.4	1.3	-2.8	-4.7	-3.8	3.6	-1.5	3.6	-3.3	3.8	-2.9
Hayfever, allergic rhinitis or eczema	1.1	2.3	5.2	-2.0	-1.3	-2.3	-1.1	-2.1	-0.3	0.6	0.1	-2.0	0.2	-2.0
Multivitamins +/- minerals	0.1	0.1	0.3	0.1	0.5	0.0	-0.1	0.3	0.0	0.6	0.2	-0.2	-0.2	-0.3
Stomach or abdominal pain in last month	0.5	0.6	2.8	-0.7	0.1	-0.8	-1.7	-1.0	0.8	-0.6	0.1	-0.6	0.3	0.1
Supplements: Glucosamine	0.4	0.6	1.5	-0.5	-0.8	-1.1	-0.8	-0.8	-1.2	0.6	-0.7	-0.5	-0.3	-0.6
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	1.1	0.0	0.2	0.0	-0.2	0.4	0.2	0.4	1.1	0.1	0.7	-0.0
Medication: Atenolol	0.5	0.6	3.6	-0.1	0.5	0.7	-1.0	0.0	0.3	1.9	0.3	0.4	0.4	0.5
Medication: Levothyroxine sodium	0.7	1.2	3.2	1.7	0.5	1.3	0.4	1.4	0.1	0.2	-0.2	1.8	-0.2	1.7
Sitting height	0.2	1.2	4.0	-1.6	-2.0	-1.3	-0.7	-1.2	-0.8	-0.2	-0.4	-1.5	0.2	-0.6
Chronic bronchitis/emphysema (father)	0.4	0.5	1.2	-1.0	-0.3	-0.8	-0.2	0.1	1.1	-1.0	0.1	-0.7	1.1	-0.5
High blood pressure (mother)	1.0	1.5	2.6	-1.4	0.7	-1.6	-0.0	-1.4	0.3	-0.2	1.5	-1.5	1.6	-1.5
Body mass index (BMI)	1.0	4.3	10.2	-2.1	-0.5	-2.5	-3.2	-2.5	0.8	-1.4	2.1	-2.4	1.1	-2.6
Impedance of leg (left)	2.3	11.3	24.3	4.2	1.9	4.6	3.7	4.9	-0.0	2.3	-0.8	4.5	-0.6	4.1
Leg predicted mass (left)	1.4	7.3	13.5	-3.4	-1.8	-3.6	-3.1	-3.6	0.1	-1.7	1.2	-3.7	0.9	-3.4
Trunk fat mass	0.5	2.3	6.4	-1.2	1.0	-1.3	-1.9	-1.3	1.4	-0.7	2.5	-1.4	1.6	-1.7
Waist circumference	0.9	3.3	8.1	-1.8	-0.8	-2.2	-2.8	-2.1	0.7	-1.4	1.4	-2.2	0.5	-2.5
Number of incorrect matches in round	0.4	0.7	3.2	0.1	1.8	1.0	-0.3	0.6	0.5	-0.7	0.8	0.7	0.3	1.2
Past tobacco smoking	1.4	2.5	6.2	-2.1	0.8	-1.6	-2.5	-2.0	0.7	-0.4	0.9	-2.1	0.6	-1.9
Alcohol usually taken with meals	0.7	1.2	3.4	-0.7	-0.0	-1.8	-1.1	-1.1	-0.2	-0.6	-0.8	-1.5	0.1	-1.9
Nervous feelings	0.6	1.2	3.3	0.6	1.2	1.8	0.7	1.5	0.6	0.9	0.7	1.2	0.9	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.5	-0.6	0.2	-0.7	0.7	-0.1	0.7	-0.1	0.3	-0.1	0.0	0.2
Hearing difficulty/problems with background noise	0.1	0.2	0.7	-0.0	0.1	0.4	0.3	0.4	0.2	0.9	-0.4	0.6	0.2	0.6
Hair/balding pattern: Pattern 2	0.2	0.2	0.7	-0.1	0.2	-0.2	-0.9	-0.7	-0.4	-0.3	0.5	-0.3	-0.3	-0.6
Had menopause	0.1	0.1	0.8	-0.2	0.2	0.2	0.9	0.0	0.5	0.6	0.2	0.1	0.1	0.2
Had other major operations	1.3	1.5	3.5	-1.7	-0.5	-1.9	-0.6	-1.7	-0.6	-1.2	-0.2	-1.6	-0.8	-1.6
Forced vital capacity (FVC)	0.1	0.3	1.1	0.4	-0.3	0.4	-1.1	0.5	-0.8	-0.1	0.2	0.5	0.3	0.7
Heel bone mineral density (BMD) T-score, automated (right)	1.7	3.9	7.9	-1.7	1.9	-1.5	-1.4	-2.2	2.8	-1.9	2.1	-2.1	1.9	-1.9
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.7	-0.8	1.3	-0.8	-0.4	-0.4	0.8	-0.2	0.7	-0.7	0.3	-0.8
Qualifications: None of the above	0.2	0.4	1.1	0.6	0.4	0.6	0.4	0.3	-0.4	0.2	-0.6	0.9	-0.7	1.0
Financial difficulties in last 2 years	0.8	1.1	3.3	-1.2	0.3	-0.8	-1.3	-1.0	0.6	1.0	1.8	-0.9	0.9	-0.9
Mouth/teeth dental problems	0.5	0.7	1.5	1.0	-0.1	0.7	0.1	1.0	-0.9	-0.6	-1.2	0.9	-0.9	1.1
Heart attack	1.0	1.3	4.4	-0.9	0.8	-0.8	-1.3	-0.2	2.1	-0.1	1.3	-0.9	1.8	-0.7
Allergy	0.6	1.5	4.0	1.5	2.0	1.6	0.4	1.5	0.8	-0.1	0.7	1.4	0.3	1.3
Pain all over the body in last month	0.2	0.2	0.5	0.2	-0.2	-0.1	0.3	0.4	-0.6	-0.7	-0.5	0.1	-0.7	-0.2
Diabetes (self-reported)	1.1	1.8	4.1	-1.4	1.4	-0.9	-1.3	-1.1	2.0	-0.0	1.9	-0.8	1.7	-0.7
Hayfever/allergic rhinitis (self-reported)	1.8	2.3	5.6	-2.4	-0.2	-2.3	-0.6	-2.0	1.1	-0.3	0.2	-2.2	0.5	-2.1
Medication: Ramipril	5.3	6.8	14.3	-2.3	2.6	-1.9	-2.4	-2.5	3.0	-2.2	3.3	-2.2	3.8	-2.0
Medication: Simvastatin	3.9	5.7	15.2	-2.3	2.0	-1.5	-2.5	-1.9	3.2	1.0	3.0	-1.8	3.9	-1.7
Fluid intelligence score	0.7	1.5	3.4	-1.8	-1.6	-1.6	0.7	-1.3	-1.1	-0.0	-0.4	-1.6	-0.3	-1.4
Illnesses of siblings	0.7	1.0	3.9	0.4	-1.7	-0.3	0.7	0.9	-1.2	-0.3	-1.1	0.0	-2.0	-0.3
Neuroticism score	0.5	1.1	2.8	0.3	1.6	0.9	-0.1	0.7	1.5	0.6	1.7	0.9	1.0	0.6
Weight	0.9	4.6	8.3	-2.4	-1.2	-2.7	-2.9	-2.7	0.5	-1.4	1.7	-2.7	1.1	-2.7
Impedance of arm (right)	1.5	6.9	15.6	2.6	4.0	2.7	3.1	3.6	1.8	1.7	1.4	2.7	1.7	2.4
Arm fat percentage (right)	0.5	2.1	5.1	-1.0	0.8	-1.3	-2.1	-1.1	1.2	-0.7	2.3	-1.3	1.7	-1.7
Trunk fat-free mass	1.4	7.9	15.4	-3.4	-3.9	-3.5	-2.9	-3.7	-0.9	-0.7	-0.6	-3.6	-0.3	-3.2
Hip circumference	2.3	10.1	17.5	-3.4	0.6	-3.3	-4.2	-3.7	2.8	-0.7	3.5	-3.6	3.2	-3.8
Time employed in main current job	3.7	4.3	11.4	-2.2	-0.1	-2.9	-2.8	-2.3	0.4	0.4	0.9	-2.9	0.6	-3.4
Alcohol intake versus 10 years previously	0.4	0.6	3.3	-0.0	0.7	0.9	-0.5	0.1	0.2	1.8	1.1	0.4	0.3	0.5
Father’s age at death	1.5	2.0	3.9	2.0	-1.1	1.0	1.5	1.8	-1.2	0.4	-1.4	1.6	-1.5	1.6
Worrier / anxious feelings	0.1	0.2	1.0	-0.2	1.0	0.8	-0.4	-0.1	0.4	0.7	0.2	0.2	0.2	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.5	0.1	0.6	-0.5	0.3	-0.1	-0.5	-0.7	-0.0	0.0	-0.6	0.0
Falls in the last year	3.0	4.0	6.5	2.1	-2.0	2.2	1.9	2.5	-2.4	-1.0	-1.2	2.2	-1.9	2.1
Hair/balding pattern: Pattern 3	0.2	0.2	1.3	0.2	0.3	-0.0	1.2	0.9	0.0	-0.1	-0.2	0.1	-0.2	0.3
Number of live births	0.3	0.4	1.3	0.4	-0.1	0.4	-1.1	0.3	-0.9	0.3	-1.2	0.6	-0.8	0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.5	1.1	-0.6	0.9	-0.4	1.2	-1.2	0.3	-0.4	1.2	-0.3	1.2
Pulse rate	2.1	3.6	7.3	1.8	-1.9	1.1	2.4	1.6	-1.5	-0.7	-2.7	1.7	-2.5	1.8
Happiness	0.8	1.0	3.2	0.6	0.2	0.7	1.8	1.4	0.7	-1.4	-0.3	0.9	-0.1	1.3
Noisy workplace	0.4	0.5	2.7	-0.1	-1.6	-0.3	-0.8	-1.0	0.3	-0.8	-0.6	-0.2	-0.2	-0.2
Qualifications: A levels/AS levels or equivalent	0.9	2.1	3.7	-1.9	0.2	-1.8	-0.2	-1.6	0.8	0.9	1.2	-1.8	1.9	-1.8
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	3.0	0.2	-0.9	-1.1	0.4	-0.1	-1.1	-0.5	-1.0	-0.4	-1.7	-0.9
Mouth/teeth dental problems: Dentures	0.7	1.2	3.1	-1.3	0.2	-1.0	-1.2	-1.8	0.8	-0.3	0.7	-1.5	0.4	-1.5
Asthma	0.2	0.5	1.0	-0.7	-0.7	-0.6	-0.9	-1.0	-0.1	-0.0	-0.3	-0.9	-0.0	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.9	0.5	-0.7	0.0	0.3	0.6	-0.3	-1.0	-0.3	0.2	-0.6	-0.2
Medication: Cholesterol lowering	2.3	3.5	9.4	-1.9	1.1	-1.6	-1.1	-1.6	2.8	0.7	2.3	-1.6	3.1	-1.4
Depression (self-reported)	0.6	0.7	1.7	-1.0	1.1	-0.6	0.7	-0.5	0.7	-0.4	1.3	-0.9	0.9	-0.6
Medication: Lansoprazole	1.7	1.9	3.1	-1.5	0.6	-1.4	-0.4	-1.0	1.2	-1.8	1.8	-1.5	1.8	-1.5
Prospective memory result	0.6	0.7	1.8	1.3	1.1	1.3	-0.0	0.7	-0.3	0.0	0.5	1.0	-0.2	0.9
Lung cancer (father)	2.5	3.0	6.0	2.0	-0.4	2.2	2.4	2.4	-0.8	0.9	-0.6	2.4	-0.5	2.0
Illnesses of mother	1.5	1.9	12.0	0.3	-1.8	0.8	-0.0	0.3	-0.3	3.5	-1.4	0.7	-1.3	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.4	0.4	-0.7	0.3	-1.0	0.7	-1.0	1.2	-0.3	0.6	-0.5	0.7
Pulse wave Arterial Stiffness index	0.1	0.1	0.8	0.2	0.1	0.1	0.0	0.1	-0.1	0.3	0.1	0.3	-0.9	-0.1
Impedance of arm (left)	1.5	7.0	21.1	2.3	4.6	2.4	2.9	3.4	2.2	1.0	1.9	2.5	2.0	2.2
Arm fat mass (right)	0.9	3.6	7.2	-1.9	-0.1	-2.1	-2.7	-2.1	1.0	-1.1	2.1	-2.2	1.5	-2.5
Trunk predicted mass	1.4	8.0	15.5	-3.5	-3.9	-3.5	-2.8	-3.7	-0.9	-0.9	-0.7	-3.7	-0.3	-3.2
Standing height	0.0	0.5	1.9	-0.9	-1.4	-0.7	0.2	-0.6	-0.5	-0.0	-0.4	-0.9	0.3	-0.4
Length of working week for main job	0.8	0.9	5.2	-0.5	1.1	-0.7	-2.3	-0.8	0.3	0.3	0.2	-0.9	-0.4	-1.0
Exposure to tobacco smoke at home	2.3	2.6	6.5	2.5	-0.4	2.2	0.8	2.0	-0.6	-1.2	-1.0	2.2	-1.4	1.7
Breastfed as a baby	0.6	0.7	1.7	0.6	-0.7	0.3	0.3	0.1	-1.3	1.1	-1.2	0.7	-1.2	0.4
Tense / ‘highly strung’	0.7	1.1	2.5	1.2	0.5	1.1	1.3	1.6	0.5	-0.9	0.4	1.4	0.3	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	2.0	-0.9	-0.4	-1.1	1.4	-0.3	-0.8	0.3	-0.1	-0.8	-0.7	-0.7
Hair/balding pattern: Pattern 4	0.2	0.4	0.9	-0.2	0.6	-0.5	0.9	-0.0	1.0	-0.7	0.3	-0.5	0.9	-0.8
Birth weight of first child	0.2	0.4	1.3	0.5	-1.1	0.3	0.6	0.4	-0.2	-1.0	-0.4	0.6	0.2	0.9
Peak expiratory flow (PEF)	0.9	2.0	3.3	1.7	-1.1	1.2	0.6	1.6	-1.8	0.0	-1.5	1.7	-1.3	1.8
Pulse wave reflection index	2.2	2.7	6.0	-1.9	1.4	-0.6	-2.2	-1.9	0.9	-0.9	2.4	-1.5	1.7	-1.6
Ever highly irritable/argumentative for 2 days	0.6	0.7	5.4	-0.2	0.4	-0.3	-0.1	0.6	-0.5	2.3	-0.5	0.5	-0.8	0.7
Loud music exposure frequency	2.5	2.7	5.9	2.3	-1.0	1.9	1.5	2.4	-1.2	-0.2	-0.6	2.4	-0.7	2.1
Qualifications: O levels/GCSEs or equivalent	2.0	3.2	6.6	-2.5	-0.2	-2.2	-1.2	-2.2	1.1	0.8	1.0	-2.4	1.5	-2.6
Mouth/teeth dental problems: Bleeding gums	1.8	2.4	8.0	-0.7	1.5	-0.1	-0.6	-0.5	2.8	1.1	2.3	-0.6	2.5	-1.2
Blood clot in the leg (DVT)	1.7	2.1	5.3	-0.0	-1.9	0.7	1.9	0.9	-2.3	-0.2	-1.8	0.6	-2.3	1.0
Medication: Paracetamol	0.8	1.3	2.9	1.3	0.1	1.3	0.1	1.7	-1.5	1.3	-0.3	1.4	-0.7	1.2
Headache pain in last month	0.5	0.9	4.8	-0.0	-0.6	0.0	0.5	0.6	-1.0	2.2	-0.8	0.4	-1.2	0.9
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	7.1	1.1	-1.1	0.8	1.1	1.3	-2.6	-0.1	-2.0	0.9	-2.7	0.7
Glaucoma (self-reported)	0.3	0.4	0.7	0.2	0.7	0.7	0.7	0.2	-0.1	-0.4	0.8	0.8	0.5	0.6
Gout (self-reported)	0.2	0.2	0.5	0.3	0.7	0.5	-0.0	0.2	-0.5	0.7	0.4	0.5	-0.1	0.7
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.8	0.7	0.9	0.7	-0.3	0.6	0.5	0.5	0.0	0.8	0.2	0.7
Medication: Amlodipine	2.4	3.3	9.3	-1.9	1.3	-1.5	-1.4	-1.6	3.1	-0.0	1.9	-1.8	2.4	-1.5
Medication: Ventolin 100micrograms inhaler	1.0	1.3	3.4	0.0	1.4	0.3	-1.6	-0.7	1.8	0.3	1.8	-0.1	1.7	-0.2
Birth weight	2.3	5.0	14.0	0.8	-2.9	-0.1	1.4	0.6	-3.7	-1.9	-3.5	0.2	-3.7	0.2
Chronic bronchitis/emphysema (mother)	2.2	2.5	4.2	1.8	-0.7	1.7	1.6	2.0	-1.5	-1.7	-0.9	1.7	-1.3	1.9
High blood pressure (siblings)	1.1	1.6	3.8	-0.7	0.9	-0.5	-1.8	-1.5	1.7	-1.2	1.1	-0.8	1.9	-0.9
Forced vital capacity (FVC), Best measure	0.1	0.4	2.9	-0.3	0.2	-0.1	-1.7	0.0	-0.1	0.6	0.6	-0.1	0.6	0.1
Body fat percentage	0.4	1.5	6.8	-0.2	1.7	-0.4	-1.1	-0.2	1.5	-0.4	2.6	-0.4	1.5	-0.9
Leg fat percentage (right)	0.2	0.6	3.1	0.5	0.3	0.0	-1.1	0.2	0.8	-0.6	1.8	0.2	0.6	-0.3
Arm fat-free mass (right)	1.2	5.9	11.1	-3.0	-3.2	-3.0	-2.5	-3.3	-0.9	-1.2	-0.3	-3.1	-0.5	-2.7
Exposure to tobacco smoke outside home	0.6	0.8	4.1	0.5	-2.0	0.2	-0.8	-0.0	-0.7	0.3	-0.7	0.6	-1.5	0.6
Comparative body size at age 10	0.5	1.4	3.5	-1.2	-0.0	-1.8	-0.4	-1.6	0.3	-0.2	1.0	-1.5	1.0	-1.9
Number of full brothers	0.5	0.6	2.8	-0.3	-0.3	-0.3	-0.2	-0.8	1.3	0.2	1.1	-0.2	1.7	-0.6
Worry too long after embarrassment	0.8	1.3	4.2	0.7	1.0	1.8	0.4	1.6	-0.3	0.8	0.4	1.6	-0.0	2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.7	5.7	1.3	1.8	2.0	1.9	1.8	-0.0	1.9	0.0	2.2	-0.1	2.4
Wheeze or whistling in the chest in last year	0.3	0.6	1.1	1.0	0.5	0.3	0.6	1.0	-0.6	-0.5	-1.0	0.8	-0.5	0.9
Number of children fathered	0.2	0.2	0.7	0.0	-0.8	-0.8	0.7	-0.3	-0.2	0.5	-0.0	-0.4	-0.1	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	4.6	1.1	2.0	1.4	2.1	1.2	-0.0	1.3	-0.1	1.3	-0.4	1.2
Age at first live birth	0.5	0.9	2.1	-1.0	0.4	-1.1	0.3	-0.7	0.8	0.0	1.5	-1.2	1.2	-0.8
Pulse wave peak to peak time	0.1	0.1	0.9	-0.2	0.0	-0.1	0.1	-0.1	0.1	-0.2	0.0	-0.3	0.9	0.2
Health satisfaction	0.5	0.6	1.7	0.3	1.2	-0.4	1.3	1.1	0.9	-0.7	0.8	0.1	0.5	0.1
Shortness of breath walking on level ground	4.3	5.2	9.1	-3.0	0.4	-2.5	-2.9	-2.9	1.2	-1.7	1.6	-2.8	1.6	-2.7
Qualifications: College or University degree	0.4	1.2	2.7	-1.5	-0.3	-1.3	-1.1	-1.4	0.1	-0.5	-0.4	-1.6	0.6	-1.5
Eye problems/disorders: None of the above	0.6	0.6	1.6	0.2	-1.2	0.6	0.3	0.3	-1.1	1.3	-1.1	0.3	-0.8	0.6
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.2	-1.4	-0.2	-1.3	-0.0	-1.3	-0.3	-0.9	0.2	-1.5	-0.2	-1.3
Emphysema/chronic bronchitis	0.7	0.8	3.8	0.5	-0.9	-0.0	-0.3	0.2	-1.1	-2.0	-0.7	0.2	-1.2	0.4
Medication for pain relief, constipation, heartburn	0.8	1.3	2.6	-1.2	0.3	-1.4	-0.7	-1.6	1.2	-1.1	0.8	-1.6	0.7	-1.5
Neck or shoulder pain in last month	0.4	0.6	1.4	0.7	0.2	0.2	0.2	1.1	-1.2	-0.0	-0.9	0.8	-1.2	0.8
Medication: Blood pressure	1.9	3.3	10.5	-1.3	1.8	-0.9	-1.6	-1.8	3.2	-0.6	2.1	-1.2	2.7	-0.8
Angina (self-reported)	1.6	2.1	6.4	-1.5	1.1	-0.5	-0.9	-1.3	2.1	0.7	2.0	-1.0	2.5	-1.1
Migraine (self-reported)	0.2	0.3	0.9	0.6	-0.4	0.4	0.9	0.9	0.2	-0.1	0.1	0.5	0.5	0.2
Medication: Ibuprofen	0.3	0.4	1.5	0.9	-0.4	0.4	0.8	1.2	-0.1	-0.5	-0.3	0.7	-0.5	0.1
Medication: Allopurinol	0.4	0.6	2.4	-0.5	1.3	-0.0	-0.4	-0.2	0.3	0.1	1.6	-0.4	1.3	-0.1
Medication: Omeprazole	3.2	3.9	5.8	2.0	-1.5	2.1	2.1	2.4	-2.1	-0.2	-1.6	2.4	-1.7	2.4
Medication: Seretide 50 evohaler	0.5	0.5	2.1	0.3	-0.9	-1.2	-0.7	0.3	-0.2	-0.2	-1.0	-0.1	-1.5	0.1
Mean time to correctly identify matches	0.8	1.4	7.1	-0.4	1.8	0.6	-1.8	-0.7	0.6	2.7	0.2	-0.3	0.7	-0.6
Heart disease (mother)	0.3	0.3	1.0	-0.5	0.7	-0.3	-0.4	-0.9	-0.3	-1.0	0.3	-0.5	0.5	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.7	4.4	8.4	2.4	-1.0	2.6	0.2	2.2	-2.6	-0.5	-2.1	2.6	-1.8	2.9
Whole body fat mass	0.4	1.8	4.4	-1.1	0.4	-1.3	-1.9	-1.2	1.0	-0.8	2.1	-1.4	1.2	-1.6
Leg fat mass (right)	0.4	1.6	3.9	-0.9	-0.3	-1.3	-2.0	-1.2	0.5	-1.2	1.8	-1.2	0.7	-1.4
Arm predicted mass (right)	1.2	6.0	11.1	-3.0	-3.2	-3.1	-2.4	-3.3	-0.9	-1.0	-0.4	-3.2	-0.4	-2.9
Pulse rate, automated reading	1.7	5.6	14.7	2.1	-2.5	1.6	1.8	1.9	-3.1	-0.1	-3.1	2.1	-3.8	1.8
Alcohol intake frequency.	1.7	3.9	10.6	-2.1	1.1	-1.1	-2.2	-2.0	2.2	3.2	2.1	-1.4	1.8	-1.5
Comparative height size at age 10	0.2	0.9	3.4	0.1	1.0	0.8	-0.2	0.2	1.2	1.1	1.5	0.1	1.9	0.1
Number of full sisters	0.3	0.3	0.7	0.7	-0.2	-0.4	-0.3	0.7	-0.8	0.2	-0.6	0.5	-0.8	0.5
Suffer from ‘nerves’	0.6	1.0	2.0	-1.4	-0.4	-1.1	-0.5	-0.4	1.3	-0.9	0.9	-1.0	1.4	-1.1
Overall health rating	0.2	0.5	2.4	-0.5	1.5	-0.2	-0.2	0.1	0.6	-1.1	1.2	-0.2	-0.2	-0.0
Chest pain or discomfort	0.3	0.4	3.3	-0.4	0.0	0.4	-0.3	-0.0	0.3	-1.8	0.7	-0.0	0.5	0.2
Had major operations	0.3	0.4	1.0	-0.2	1.0	-0.8	0.4	-0.3	0.3	-0.7	0.7	-0.7	-0.1	-0.7
Age at last live birth	0.3	0.5	2.3	-0.0	0.3	-0.3	0.1	0.2	0.9	0.0	1.5	-0.2	1.5	-0.1
Family relationship satisfaction	0.5	0.6	4.2	-0.9	0.3	-0.6	0.7	-0.1	0.7	-2.0	0.1	-0.8	0.2	0.0
Leg pain on walking	1.0	1.2	2.6	-1.6	1.2	-0.8	-1.6	-1.4	0.2	1.2	1.0	-1.0	0.3	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.0	0.4	-0.4	1.0	-0.9	0.5	-0.5	0.1	-0.5	0.3	-0.9	0.2
Commuting to job workplace: Car/motor vehicle	0.9	1.1	2.2	1.3	1.4	1.4	0.1	0.7	-0.1	-0.8	1.0	1.4	-0.1	1.5
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	1.4	-0.6	-0.4	0.0	-0.8	-0.9	0.0	-0.1	-1.2	-0.5	0.1	-0.2
Medication: Aspirin	0.5	0.6	3.5	-0.1	1.9	0.4	-0.3	-0.3	0.8	0.5	0.9	0.4	0.9	0.6
Supplements: Vitamin C	0.8	0.9	4.9	-0.1	2.2	-0.3	-0.3	-0.4	0.9	1.5	0.7	-0.1	1.0	-0.5
Knee pain experienced in last month	1.0	1.5	3.5	-1.9	0.0	-1.2	-1.4	-1.8	0.7	-0.3	1.3	-1.5	0.3	-1.3
Hypertension (Self-reported)	3.2	8.8	18.9	-3.2	1.4	-2.5	-4.3	-3.4	3.1	-1.1	3.1	-3.1	3.2	-2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	1.2	-0.0	-0.0	-0.0	0.3	0.6	-0.9	-1.1	-0.2	-0.1	-0.8	-0.1
Illnesses of father: Heart disease	3.6	5.0	10.0	-2.6	0.9	-2.9	-1.8	-3.2	0.6	-2.0	1.1	-3.0	1.4	-3.0
Illnesses of siblings: Diabetes	0.2	0.3	1.0	0.4	0.6	0.5	0.7	-0.2	0.3	-0.5	1.0	0.3	0.6	0.4
Smoking status: Previous	1.5	2.2	6.2	2.2	-0.3	1.5	2.5	1.9	0.3	0.2	0.1	2.1	0.4	1.7
Forced expiratory volume in 1-second (FEV1), predicted	1.9	3.9	7.0	2.1	-1.3	2.3	1.8	2.6	-1.9	1.5	-1.4	2.2	-1.1	2.5
Whole body fat-free mass	1.4	7.8	14.2	-3.5	-3.3	-3.6	-3.1	-3.8	-0.7	-1.2	-0.0	-3.7	0.0	-3.3
Leg fat-free mass (right)	1.5	7.8	14.4	-3.5	-2.1	-3.7	-3.3	-3.7	-0.1	-1.7	1.1	-3.8	0.7	-3.5
Arm fat percentage (left)	0.6	2.5	6.1	-1.1	1.1	-1.5	-2.1	-1.2	1.4	-1.2	2.5	-1.4	1.7	-1.8
Average weekly red wine intake	0.1	0.1	0.4	-0.2	-0.1	-0.4	0.2	-0.1	0.0	-0.6	-0.4	-0.4	-0.1	-0.6
Handedness (chirality/laterality): Left-handed	3.0	3.6	8.5	-1.9	0.6	-1.5	-2.4	-2.3	2.9	1.1	1.9	-1.5	2.3	-1.2
Mood swings	0.2	0.4	2.5	-0.2	0.4	0.3	-0.7	0.0	-0.1	1.6	0.9	0.2	0.1	0.0
Loneliness, isolation	0.8	1.2	2.6	-0.9	1.5	-1.2	-0.6	-0.2	1.6	-0.5	1.6	-0.8	1.2	-0.7
Long-standing illness, disability or infirmity	0.9	1.4	2.9	-1.5	-0.1	-1.6	-0.5	-0.6	1.0	-1.1	1.3	-1.7	0.8	-1.7
Ever had bowel cancer screening	0.6	0.7	2.2	0.8	0.6	0.6	1.5	0.5	-0.8	0.9	-0.8	1.0	-0.4	0.8
Diabetes diagnosed by doctor	0.9	1.5	2.9	-1.3	1.2	-1.2	-1.1	-0.8	1.7	-0.6	1.7	-0.9	1.6	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	3.5	-0.8	0.5	-0.6	-0.1	-1.1	0.9	-1.9	1.5	-1.1	0.9	-1.0
Friendships satisfaction	0.7	0.9	4.6	-0.5	1.1	-0.7	-0.1	0.1	1.3	-2.1	0.3	-0.7	0.1	-0.6
Qualifications: nursing, teaching	0.4	0.5	2.9	-0.4	-1.7	-0.5	-1.0	0.2	-0.6	0.5	-0.4	-0.5	0.4	-0.6
Commuting to job workplace: Walk	1.5	1.6	4.8	-1.4	-1.3	-2.1	0.5	-1.1	-0.0	-0.3	-0.7	-1.7	0.0	-2.2
Eye problems/disorders: Cataract	1.6	1.9	4.5	-1.5	-0.4	-2.1	-1.2	-1.7	0.1	-1.6	-0.7	-1.7	-0.5	-1.9
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.6	1.4	-0.6	0.7	1.6	1.1	-0.8	-1.3	-0.0	1.2	-0.2	1.3
Medication for cholesterol	2.2	3.4	6.8	2.1	-0.6	2.1	2.2	2.6	-1.3	0.8	-1.3	2.1	-1.7	2.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.3	-0.2	-0.5	-0.2	-0.5	0.1	-0.3	0.6	-0.3	0.4	-0.5	0.3
Back pain experienced in last month	0.4	0.6	2.4	-0.8	-0.9	-1.5	0.5	0.4	-0.7	0.1	0.0	-1.0	0.0	-1.0
Mineral and other dietary supplements	0.8	1.0	2.1	0.6	-1.4	1.1	0.7	1.1	-1.4	0.2	-0.9	0.8	-1.3	0.9
Breast cancer (self-reported)	0.1	0.2	0.5	0.4	0.5	0.2	-0.1	-0.0	0.7	-0.0	0.4	0.1	0.7	-0.3
Asthma (self-reported)	0.3	0.6	1.3	-0.9	-0.4	-0.9	-1.0	-1.2	0.3	-0.2	0.1	-1.1	0.4	-1.2
Osteoporosis (self-reported)	1.5	1.9	5.2	0.9	-1.0	1.0	0.8	1.0	-2.3	0.4	-1.4	1.1	-2.3	1.7
Osteoarthritis (self-reported)	0.7	0.9	2.1	-1.3	-0.1	-1.2	-0.8	-1.4	0.4	-0.8	1.1	-1.2	0.2	-1.0
Medication: Aspirin	0.3	0.4	2.3	-0.3	1.5	0.2	-0.2	-0.2	0.6	0.3	0.6	0.3	0.8	0.3
Medication: Gliclazide	2.8	3.2	7.8	-1.2	2.6	-0.7	-1.9	-1.1	2.7	1.6	2.8	-0.5	1.9	-0.6
Illnesses of father: None of the above (group 1)	1.5	1.8	3.8	1.4	-1.0	1.7	0.8	1.7	-0.4	1.8	-0.4	2.0	-0.8	1.7
Smoking status: Current	0.5	0.8	3.5	-0.2	-0.5	0.1	-0.1	0.0	-1.5	-0.3	-1.6	-0.1	-1.9	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.3	1.0	0.3	0.8	0.2	0.8	-1.2	0.3	-1.1	0.9	-0.6	0.8
Whole body water mass	1.4	8.0	14.5	-3.5	-3.3	-3.6	-3.0	-3.8	-0.7	-1.3	-0.0	-3.8	0.0	-3.4
Leg predicted mass (right)	1.5	8.0	14.8	-3.5	-2.1	-3.7	-3.4	-3.8	-0.1	-1.8	1.1	-3.9	0.7	-3.5
Arm fat mass (left)	1.0	4.0	7.9	-1.9	0.2	-2.3	-2.8	-2.1	1.1	-1.3	2.3	-2.3	1.5	-2.6
Number of self-reported non-cancer illnesses	4.9	8.6	16.0	-4.0	1.1	-3.4	-3.1	-3.7	2.0	-0.3	2.1	-3.8	2.3	-3.7
Average weekly champagne plus white wine intake	0.2	0.2	1.5	-0.2	0.0	-0.5	-0.2	-0.5	0.3	1.2	0.0	-0.2	0.2	-0.4
Miserableness	0.3	0.5	2.4	0.5	0.7	0.6	0.5	0.5	0.7	1.5	0.6	0.8	-0.2	0.3
Guilty feelings	0.9	1.4	8.0	-0.3	2.8	0.2	-1.2	-0.2	0.7	0.6	1.7	-0.0	1.4	0.3
Wears glasses or contact lenses	0.3	0.3	1.7	-0.4	-0.0	-0.8	1.3	0.0	-0.0	-0.2	-0.6	-0.3	-0.5	-0.2
Ever taken oral contraceptive pill	0.1	0.1	0.2	-0.2	-0.0	0.1	-0.0	-0.2	-0.3	0.4	0.0	-0.1	0.4	0.4
Hearing aid user	0.6	0.6	2.5	0.3	-0.7	0.2	1.6	1.3	-0.5	-1.2	-0.3	0.2	-0.4	0.0
Mother’s age at death	1.1	1.4	2.9	1.1	-1.2	0.7	1.5	0.8	-1.5	0.8	-1.7	1.1	-1.2	1.0
Financial situation satisfaction	0.2	0.2	0.7	-0.3	-0.8	-0.1	-0.3	-0.2	0.1	-0.0	0.6	0.1	0.6	0.7
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.4	-0.7	0.4	-0.4	-0.3	-0.1	0.0	1.2	0.1	-0.6	0.9	-0.8
Commuting to job workplace: Public transport	0.6	0.7	2.6	-0.7	-0.3	-0.2	-0.2	-0.4	1.4	-0.5	0.7	-0.9	1.6	-0.8
Eye problems/disorders: Glaucoma	0.6	0.7	1.9	-1.4	0.3	-0.6	-0.6	-0.9	0.1	-0.6	1.3	-0.8	0.9	-1.0
Medication: Blood pressure	3.1	5.8	9.6	-2.8	0.7	-2.6	-3.1	-2.9	1.8	-0.7	2.0	-2.7	2.5	-3.1
Pain type(s) experienced in last month: Hip pain	1.4	1.7	3.3	1.6	0.5	1.8	1.3	1.8	-0.8	0.8	-0.5	1.6	-1.5	1.4
Supplements: Fish oil (including cod liver oil)	1.3	1.7	3.2	-0.9	1.1	-1.8	-1.1	-1.5	1.7	-1.1	1.0	-1.3	1.3	-1.3
High cholesterol (Self-reported)	2.0	3.6	7.2	-2.0	0.6	-1.9	-1.6	-2.1	2.6	-0.4	2.0	-1.8	2.7	-1.8
Medication: Bendroflumethiazide	2.6	3.9	10.2	-2.2	1.6	-1.6	-3.2	-2.4	1.9	0.9	1.3	-1.9	2.0	-1.9
Medication: Paracetamol	1.3	2.0	4.8	1.4	-0.5	1.2	0.5	1.9	-2.2	1.9	-0.8	1.5	-1.4	1.2
Medication: Lisinopril	3.1	4.0	7.3	-2.0	0.9	-2.0	-2.1	-1.8	2.7	-0.5	2.5	-1.9	2.6	-1.8
Medication: Atorvastatin	0.2	0.2	0.7	0.1	-0.8	-0.3	-0.4	-0.2	0.7	-0.8	-0.1	0.0	-0.0	-0.1
Illnesses of father: High blood pressure	0.6	0.7	1.6	-0.9	0.9	-0.7	-0.5	-0.9	1.1	-0.5	1.3	-0.7	0.9	-0.6
Alcohol drinker status: Never	1.6	1.9	3.9	-2.0	1.1	-0.8	-0.8	-1.8	1.1	1.2	1.3	-1.4	1.4	-1.8
Ever smoked	1.3	2.3	3.3	1.4	-1.3	1.4	1.6	1.4	-1.7	1.2	-1.6	1.8	-1.3	1.7
Basal metabolic rate	1.3	7.2	12.9	-3.3	-2.8	-3.4	-3.2	-3.6	-0.3	-1.3	0.5	-3.6	0.4	-3.3
Leg fat percentage (left)	0.1	0.4	2.4	0.4	0.0	-0.0	-1.0	0.3	0.5	-0.7	1.6	0.1	0.4	-0.5
Arm fat-free mass (left)	1.2	6.2	11.0	-3.0	-3.3	-3.0	-2.7	-3.3	-0.6	-1.0	-0.3	-3.2	-0.2	-3.0
Number of operations (self-reported)	1.2	1.8	4.1	-1.6	-1.5	-2.0	0.0	-1.6	-1.0	-0.7	-0.7	-1.6	-1.1	-1.6
Average weekly beer plus cider intake	3.3	4.7	10.4	3.0	-0.3	2.6	2.0	2.9	-1.2	-0.3	-1.2	3.2	-1.4	3.0
Irritability	0.2	0.4	1.4	0.8	0.0	0.5	0.3	1.2	-0.3	-0.3	0.7	0.8	-0.2	0.6
Risk taking	1.5	2.1	3.3	1.7	-1.8	1.4	0.7	1.5	-1.6	-0.8	-1.5	1.6	-1.7	1.3
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.2	1.5	-0.1	1.2	1.3	1.1	-0.4	0.9	-1.3	1.5	-0.3	1.3
Fractured/broken bones in last 5 years	2.1	2.7	7.1	1.8	-1.2	1.1	2.7	2.2	-0.9	-0.2	-0.8	2.0	-1.5	1.8
Age started oral contraceptive pill	1.3	1.7	4.0	2.0	0.2	1.6	0.5	1.7	-0.0	-1.8	-0.3	1.6	-0.3	1.7
Diastolic blood pressure, automated reading	0.1	0.4	3.3	-0.0	-0.0	0.2	-1.8	-0.4	-0.6	-0.9	0.4	-0.0	-0.1	0.3
Ever depressed for a whole week	1.2	1.5	4.2	-1.8	0.1	-2.0	-1.0	-1.4	-0.0	-1.2	0.1	-1.8	-0.2	-1.4
Unable to work because of sickness or disability	0.8	1.0	4.1	0.0	-0.8	-0.5	-0.8	0.1	-1.7	-0.5	-1.4	-0.3	-2.0	-0.2
Commuting to job workplace: Cycle	0.6	0.7	2.5	0.2	-1.5	0.9	0.1	0.4	-0.8	0.2	-1.6	0.5	-1.0	0.3
Myopia	0.5	0.8	2.1	-1.1	-0.5	-1.5	-0.3	-1.0	0.0	-1.0	0.2	-1.2	0.5	-0.9
Vascular/heart problems diagnosed by doctor	4.0	10.8	21.8	3.3	-1.9	2.5	4.7	3.6	-4.0	1.0	-3.7	3.0	-4.2	2.5
Cholesterol lowering medication	2.5	3.6	8.4	-1.4	1.7	-1.3	-2.5	-1.4	2.5	-0.9	2.4	-1.3	2.9	-1.5
Medication: Omeprazole (e.g. Zanprol)	3.2	3.9	7.1	1.9	-1.6	2.1	2.4	2.7	-2.0	-0.7	-1.5	2.2	-1.5	2.2
Pain experienced in last month	0.1	0.2	0.6	0.8	-0.0	0.4	0.2	-0.5	-0.2	-0.4	-0.5	0.3	-0.5	-0.1
Supplements: Calcium	0.5	0.5	2.5	0.6	-0.2	0.2	1.6	0.5	-0.3	1.0	-0.7	0.8	-0.5	0.5
Basal cell carcinoma (self-reported)	0.5	0.7	1.4	-0.4	-1.1	-1.1	-0.2	-0.5	-1.1	0.5	-0.8	-0.6	-1.2	-0.7
Heart attack/myocardial infarction (self-reported)	0.6	0.8	3.5	-0.6	0.4	-0.6	-1.0	0.1	1.9	-0.1	1.1	-0.6	1.4	-0.5
Deep venous thrombosis (DVT) (self-reported)	1.1	1.5	4.2	-0.5	-1.6	0.5	1.4	0.5	-1.9	-0.1	-1.4	0.2	-2.0	0.7
Heart disease (siblings)	0.3	0.4	1.4	-0.4	0.8	-0.2	-0.4	-1.0	0.7	-0.2	0.7	-0.3	1.2	0.2
Alcohol drinker status: Previous	0.8	1.0	3.1	-1.0	0.3	-0.7	-1.4	-1.0	0.6	1.8	1.3	-0.6	0.2	-0.8
Pack years of smoking	0.3	0.5	1.7	0.6	-0.5	0.0	-0.1	0.8	-0.7	-0.6	-1.3	0.3	-1.2	0.2
Impedance of whole body	2.1	10.7	22.5	3.8	3.9	4.0	3.7	4.7	1.3	1.8	0.7	4.1	0.9	3.6
Leg fat mass (left)	0.4	1.4	3.3	-0.8	-0.4	-1.2	-1.8	-1.1	0.5	-1.2	1.8	-1.2	0.7	-1.4
Arm predicted mass (left)	1.3	6.5	12.5	-3.0	-3.5	-3.1	-2.7	-3.3	-0.7	-1.1	-0.4	-3.2	-0.3	-3.0