Hub : Genes

WIPF1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.2970 0.0460 0.0e+00 0.282 0.263 0.294 0.282 0.289 2.1e-34 7.2e-32 4.3e-36 2.1e-34 1.8e-35
2 GTEx Adipose Subcutaneous 0.0890 0.0360 4.8e-03 0.038 NA 0.026 NA 0.036 4.4e-04 NA 3.1e-03 NA 6.1e-04
3 GTEx Brain Cerebellum 0.5020 0.1010 3.3e-05 0.049 NA 0.061 NA 0.106 1.5e-02 NA 6.9e-03 NA 4.8e-04
4 GTEx Brain Cortex 0.2340 0.0830 8.2e-04 0.163 NA 0.182 NA 0.147 3.0e-05 NA 9.9e-06 NA 7.6e-05
5 GTEx Brain Hippocampus 0.2338 0.1043 9.9e-03 0.002 NA 0.024 NA 0.008 2.9e-01 NA 9.2e-02 NA 2.0e-01
6 GTEx Cells Transformed fibroblasts 0.1370 0.0450 1.5e-04 0.044 NA 0.046 NA 0.050 2.8e-04 NA 2.1e-04 NA 1.3e-04
7 GTEx Testis 0.3180 0.1020 3.4e-03 0.131 NA 0.120 NA 0.115 2.0e-06 NA 5.9e-06 NA 9.2e-06
8 GTEx Thyroid 0.1060 0.0400 1.3e-03 0.096 NA 0.066 NA 0.092 8.9e-08 NA 8.5e-06 NA 1.6e-07
9 ROSMAP Brain Pre-frontal Cortex 0.0948 0.0268 2.0e-06 0.076 0.031 0.079 0.043 0.047 4.7e-10 5.9e-05 2.1e-10 2.6e-06 8.9e-07
10 YFS Blood 0.1918 0.0296 0.0e+00 0.160 0.185 0.194 0.184 0.190 6.6e-50 4.3e-58 2.4e-61 4.7e-58 4.8e-60
11 TCGA Brain Lower Grade Glioma 0.0805 0.0299 2.8e-08 0.090 0.082 0.088 NA 0.090 1.9e-10 1.5e-09 3.3e-10 NA 2.1e-10

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 3.0 4.8 6.7 -2.5 1.0 -2.4 -2.2 -2.6 2.4 -1.4 2.0 -2.5 1.9 -2.4
Bipolar Disorder or Schizophrenia 0.7 1.8 8.8 -0.0 2.1 -0.4 -0.9 -0.5 1.8 -3.0 1.0 -0.2 0.9 -0.1
Depressed Affect (Nagel 2018) 0.5 1.1 4.2 -0.6 1.8 -0.5 0.2 -0.3 1.2 1.0 2.0 -0.3 0.9 -0.7
Depression (Nagel 2018) 0.4 0.6 2.7 -0.0 1.7 0.2 0.6 0.1 0.2 -0.6 1.6 0.1 0.9 0.1
Intelligence (Savage-Jansen 2018) 1.7 5.3 13.2 -3.6 0.3 -2.9 -0.3 -3.1 1.6 -0.1 1.8 -3.1 2.3 -2.5
Neuroticism (Nagel 2018) 0.6 1.3 4.0 0.7 2.0 1.3 1.0 1.4 0.5 0.5 1.5 1.2 0.4 0.9
Schizophrenia (2018) 1.1 2.3 7.2 2.0 1.9 1.4 0.6 1.5 0.4 -2.7 -0.3 1.7 -0.4 1.8
Schizophrenia vs Biploar Disorder 1.5 2.0 3.8 1.6 1.7 1.7 1.5 2.0 0.7 0.4 0.2 1.9 0.5 1.8
Worry (Nagel 2018) 0.4 0.8 1.8 0.7 0.7 1.3 1.3 1.3 0.6 -0.4 0.5 1.1 0.5 0.7
Alzheimer’s Disease (in mother) 0.9 1.0 2.9 0.7 1.7 0.6 0.0 1.5 0.1 -1.3 0.7 1.2 0.5 1.3
Alzheimer’s Disease (in father) 0.7 0.8 2.0 0.6 0.9 0.9 0.3 0.3 1.3 0.5 0.7 1.1 0.8 1.4
Alzheimer’s Disease (including proxy) 0.5 0.7 1.5 0.2 1.2 0.3 -0.6 0.5 1.1 -0.4 1.1 0.8 1.1 1.0
Crohns Disease (2017) 2.3 5.0 11.2 -1.8 2.0 -0.4 -2.6 -1.6 3.2 -0.1 3.4 -1.7 3.1 -2.1
Irritable Bowel Disease (IBD) 1.6 3.9 8.0 -1.9 0.9 -1.0 -1.6 -1.8 2.8 0.2 2.5 -1.8 2.7 -2.5
Ulcerative Colitis (UC) 1.3 2.5 6.6 -1.9 -0.7 -1.9 -0.5 -2.0 1.4 -0.4 1.0 -2.0 1.2 -2.6
Major Depression (MDD) 0.5 0.6 2.3 0.4 -0.6 0.7 0.6 0.1 -1.5 -0.2 -1.2 0.4 -1.2 0.5
Reaction Time 1.1 2.0 8.6 -0.2 1.9 1.0 -2.5 -0.5 1.0 2.9 0.9 -0.1 0.9 -0.3
Verbal and Numeric Reasoning (VNR) 0.7 1.8 5.2 -2.3 -0.4 -1.7 0.7 -1.6 -0.1 1.3 0.1 -1.8 0.7 -1.7
Breast Cancer 0.1 0.2 1.1 0.1 -0.1 0.3 0.5 -0.2 -0.4 1.1 0.7 0.1 -0.1 0.3
Ovarian Cancer 1.4 1.9 5.5 -1.6 1.7 -0.8 0.7 -1.6 1.2 -1.0 2.4 -1.2 1.2 -0.8
Prostate Cancer 2.7 3.7 10.5 -2.2 0.7 -1.1 -1.9 -1.9 2.4 0.3 2.5 -1.7 3.2 -1.4
Age at First Birth 0.7 1.0 2.0 1.3 0.3 1.0 0.8 1.4 -0.4 1.1 -0.3 1.4 -0.5 1.4
Bipolar Disorder (2011) 2.4 2.3 7.0 -1.5 -0.8 -1.8 -1.2 -2.1 1.6 -2.6 0.8 -1.9 0.0 0.0
Body Mass Index (BMI) (2010) 0.9 1.2 3.5 1.6 -0.3 0.8 0.1 1.6 0.0 1.9 -0.7 1.5 -0.2 1.0
Coronary Artery Disease (CAD) 2.9 3.5 7.1 -1.9 0.8 -1.7 -2.3 -2.3 1.5 -1.3 1.7 -2.4 0.8 -2.7
Crohns Disease (2012) 1.6 2.5 5.7 -1.7 0.6 -1.1 -1.9 -1.5 1.7 -0.3 1.7 -1.6 1.7 -2.4
Mean Putamen Volume 1.3 1.5 3.9 -2.0 0.4 -0.6 -0.5 -1.0 1.2 -1.1 1.1 -1.6 1.2 -1.6
Fasting Glucose 0.6 0.8 2.6 -1.1 -0.8 -0.3 -0.7 -0.6 0.9 1.6 0.8 -0.7 1.0 -0.1
HbA1C 2.3 2.6 5.2 -1.3 0.2 -1.2 -1.6 -1.8 2.1 -1.0 2.3 -1.5 2.1 -1.4
HDL Cholesterol 0.2 0.3 1.2 -0.5 0.1 -0.9 -0.2 -0.3 -0.4 -1.1 -0.2 -0.6 -0.7 -0.4
LDL Cholesterol 0.6 0.9 2.6 0.6 -0.9 0.1 0.8 0.6 -1.5 0.3 -1.5 0.4 -1.6 0.6
Lupus 0.5 0.7 1.5 0.2 -1.1 1.0 -0.4 0.2 -0.9 1.2 -1.2 0.4 -0.9 0.8
Neuroticism (2016) 0.2 0.2 1.5 0.0 0.6 0.7 1.2 0.1 0.0 -0.3 0.2 0.3 -0.0 0.0
Primary Biliary Cirrhosis 0.4 0.5 1.4 -1.0 -0.5 0.0 -1.1 -0.4 -0.6 1.2 -0.9 -0.5 0.2 -0.4
Rheumatoid Arthritis 0.2 0.3 2.2 -0.0 -0.3 0.3 -0.6 -0.2 -0.4 1.5 -0.2 0.4 -0.3 0.3
Schizophrenia (2014) 0.9 2.0 4.5 1.8 1.8 1.8 0.8 1.2 0.5 -2.1 -0.4 1.6 -0.2 1.7
Triglycerides 1.5 2.4 4.1 -1.6 0.8 -1.3 -2.0 -1.5 2.0 0.8 1.6 -1.6 1.6 -1.9
Type 2 Diabetes (T2D) (2012) 0.3 0.3 1.2 0.4 0.7 -0.3 -0.7 -0.3 0.8 -0.0 1.1 0.2 0.4 -0.2
Ulcerative Colitis 0.4 0.5 2.0 -0.8 -0.9 -0.9 0.9 -0.5 0.1 -0.1 -0.2 -0.8 0.3 -1.4
Blood Eosinophil Count 0.9 7.2 14.7 -3.5 -0.2 -3.8 -2.8 -3.5 1.1 0.4 2.4 -3.6 1.3 -3.2
Blood Platelet Count 0.2 2.8 9.2 -2.1 -0.0 -1.6 -3.0 -1.6 1.5 1.6 1.0 -1.3 1.2 -1.7
Blood Red Count 0.3 3.1 6.2 2.5 0.7 2.5 1.5 2.5 -0.6 0.4 -0.2 2.4 -0.9 2.3
Blood White Count 0.1 0.9 3.6 0.1 1.0 0.7 -1.2 0.7 0.7 0.8 1.9 0.4 1.4 -0.1
Heel T-Score 0.7 5.7 17.6 -1.2 3.0 -0.8 -1.3 -1.9 4.2 -1.4 3.3 -1.6 3.0 -2.0
BMI 1.4 8.2 18.6 -2.6 -1.4 -3.5 -4.3 -3.6 0.9 -2.2 2.1 -3.4 1.1 -3.9
Height 0.0 0.7 1.9 0.4 -1.4 0.5 1.3 0.6 -1.2 -0.8 -0.8 0.1 -0.0 0.7
Waist Hip Ratio (WHR) 1.0 4.4 12.5 1.6 -2.6 1.3 1.1 1.6 -2.6 -0.5 -3.1 1.5 -3.5 1.3
Systolic Blood Pressure 3.6 18.3 40.3 -2.8 4.5 -2.0 -6.1 -4.0 5.3 -0.6 5.4 -3.1 6.3 -2.7
Smoking Status 1.3 3.1 5.6 1.8 -0.3 2.1 2.3 2.4 -1.8 -0.3 -1.9 1.9 -1.4 1.8
Allergy or Eczema 0.7 1.8 4.1 -2.0 -0.2 -1.7 -1.2 -1.9 0.7 0.2 1.0 -1.6 1.3 -1.4
Cardiovascular Disease 3.8 12.6 25.4 -3.2 2.6 -2.5 -5.0 -3.8 4.3 -1.1 4.3 -3.1 4.5 -2.7
Hypothyroidism (self reported) 0.2 0.4 1.1 0.3 1.1 0.4 -0.8 0.0 1.0 0.1 0.6 0.3 0.8 0.4
Respiratory disease 0.2 0.4 1.8 0.1 -1.3 0.3 -0.2 0.1 -0.9 0.4 -0.8 0.1 -0.7 -0.1
Type 2 Diabetes (T2D) (2018) 0.8 1.5 3.5 -1.6 0.3 -1.9 -1.4 -1.5 1.1 -0.2 1.2 -1.3 0.6 -1.0
Lung FEV1/FVC ratio 1.1 5.6 11.9 2.4 -1.1 2.0 3.5 2.7 -2.2 1.8 -2.1 2.7 -2.4 2.4
Lung FVC 0.4 2.0 8.6 -0.9 2.0 -0.8 -2.9 -0.7 1.2 -0.9 1.6 -0.7 1.6 -0.3
Neuroticism 0.4 0.9 2.4 0.4 1.5 1.0 0.1 0.6 1.1 0.7 1.6 1.1 0.7 0.9
Chronotype (morning person) 0.4 0.9 3.1 0.7 -0.5 0.9 0.8 1.1 -1.0 0.2 -1.3 0.9 -1.8 0.8
Hair Pigment 0.0 1.4 3.0 1.7 -1.0 0.3 0.4 1.0 -1.2 -1.6 -1.7 0.6 -1.6 0.4
Tanning 0.2 2.5 5.6 1.4 -1.2 0.9 1.5 1.5 -1.9 2.4 -1.8 1.2 -1.9 0.8
Hand grip strength (left) 0.2 0.6 2.0 -0.0 -1.4 -0.0 -0.1 0.2 -1.4 0.3 -1.2 -0.0 -0.8 -0.1
Number of treatments/medications taken 1.3 2.4 3.7 -1.9 1.1 -1.8 -1.3 -1.7 1.4 0.8 1.2 -1.6 1.9 -1.8
Average weekly spirits intake 0.6 0.7 2.7 1.0 -1.7 0.6 -0.6 0.9 -0.0 0.7 -0.9 0.9 -0.3 0.8
Sensitivity / hurt feelings 0.8 1.3 2.6 1.3 1.6 1.6 0.1 1.3 -0.3 0.5 0.1 1.5 -1.0 1.5
Frequency of depressed mood in last 2 weeks 0.8 1.1 2.5 0.7 1.6 1.0 1.2 0.8 0.6 0.6 1.2 1.0 1.1 1.1
Hearing difficulty/problems: Yes 0.1 0.2 0.5 0.0 0.1 0.1 0.3 0.4 0.5 0.2 -0.4 0.6 0.3 0.7
Relative age of first facial hair 0.4 0.8 7.1 0.1 0.1 -0.8 -0.9 -0.0 -0.4 -2.7 0.6 -0.1 -0.2 0.3
Other serious medical condition/disability diagnosed by doctor 0.4 0.6 1.5 -0.8 -0.0 -0.8 -0.2 -0.8 -0.3 -1.2 0.4 -0.9 -0.7 -1.2
Ever used hormone-replacement therapy (HRT) 0.4 0.6 1.8 -0.3 -0.5 -0.7 0.6 -0.3 -0.8 -0.7 -1.1 -0.6 -1.3 -0.8
Ever had hysterectomy (womb removed) 0.2 0.2 0.7 0.2 0.5 0.2 0.1 0.5 0.8 -0.8 0.4 0.3 0.6 -0.1
Systolic blood pressure, automated reading 2.8 8.0 13.1 -2.7 2.3 -2.2 -3.6 -2.9 3.3 -0.3 3.3 -2.9 3.5 -2.5
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.6 0.4 -0.6 0.3 -0.1 0.8 -0.0 -0.1 -0.5 0.2 -0.3 0.0
Angina 1.9 2.4 6.7 -1.7 1.0 -0.8 -0.9 -1.4 2.3 0.4 2.0 -1.2 2.6 -1.3
Medication for hormone replacement therapy 0.9 1.1 2.3 -1.1 -1.2 -1.5 0.4 -1.2 -0.4 -0.5 -0.9 -1.2 -1.1 -1.1
Vitamin and mineral supplements 0.2 0.3 0.8 0.5 -0.6 0.7 0.0 0.2 0.1 -0.9 -0.1 0.7 0.4 0.8
Supplements: Zinc 1.0 1.1 4.5 1.3 2.1 1.0 1.2 1.1 -0.1 -0.1 -0.2 1.2 -0.1 1.0
Medication: Co-codamol 0.4 0.5 3.0 -0.2 -1.7 -0.6 0.2 -0.0 -0.9 -0.5 -0.6 -0.0 -0.7 -0.3
Medication: Metformin 0.5 0.7 2.0 -1.0 -0.1 -0.8 -1.3 -0.5 1.4 -0.1 0.9 -0.6 0.9 -0.4
Diabetes (father) 2.4 2.9 5.6 -2.0 0.9 -1.8 -1.0 -2.0 0.7 -2.1 1.5 -2.4 1.3 -2.1
Diabetes (mother) 1.1 1.4 3.1 -1.2 -0.6 -1.5 -0.3 -1.0 0.1 -1.7 1.2 -1.4 1.0 -1.7
Severe depression (siblings) 1.0 1.1 6.1 0.4 2.5 0.6 0.5 1.2 0.8 -0.3 1.6 0.3 0.9 0.2
Pack years adult smoking proportion 0.3 0.5 1.5 0.4 -0.3 -0.3 -0.5 0.7 -0.8 -0.9 -1.2 -0.0 -1.2 -0.1
Impedance of leg (right) 2.3 11.0 23.2 4.1 2.3 4.5 3.4 4.8 0.3 2.4 -0.6 4.4 -0.2 4.2
Leg fat-free mass (left) 1.4 7.4 13.8 -3.4 -1.8 -3.6 -3.1 -3.6 0.0 -1.7 1.2 -3.7 0.8 -3.4
Trunk fat percentage 0.6 2.4 9.1 -0.4 2.4 -0.6 -1.3 -0.4 1.9 -0.4 3.0 -0.7 1.9 -1.1
Hand grip strength (right) 0.2 0.6 2.8 -0.3 -1.7 -0.5 -0.7 -0.1 -0.9 -0.9 -0.6 -0.5 -0.4 -0.4
Townsend deprivation index at recruitment 0.2 0.3 1.0 0.1 0.8 0.1 -0.2 0.2 -0.5 0.8 -0.3 0.3 -1.0 0.4
Current tobacco smoking 0.7 1.2 5.0 0.1 -0.6 0.3 0.2 0.3 -1.9 -0.4 -1.8 0.2 -2.2 0.4
Average weekly fortified wine intake 0.9 1.0 3.0 -1.2 -0.1 -1.7 0.1 -0.7 -0.3 0.2 -0.6 -1.7 -0.3 -1.7
Maternal smoking around birth 0.5 0.8 3.8 0.6 0.6 0.2 -0.0 1.4 -0.8 -2.0 1.1 0.2 -0.4 -0.1
Fed-up feelings 0.2 0.4 1.6 -0.7 0.4 0.0 -0.3 -0.6 1.0 1.3 0.9 -0.1 -0.1 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 2.3 0.1 1.2 0.4 0.7 0.1 0.6 -0.5 1.5 0.1 0.8 0.1
Relative age voice broke 0.6 0.9 2.5 -0.1 -1.5 -1.0 -0.9 -0.4 -1.6 -0.3 -1.3 -0.0 -1.2 0.2
Taking other prescription medications 1.0 1.6 5.3 -0.8 2.3 -0.4 -1.1 -0.6 0.9 1.3 1.9 -0.4 1.8 -0.4
Age when periods started (menarche) 0.5 1.3 2.7 1.4 -1.0 0.7 0.2 1.2 -1.2 -0.8 -1.5 1.0 -1.6 1.2
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.5 -0.6 0.0 -0.5 -0.9 -0.4 0.8 -1.2 0.6 -0.5 0.5 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.6 8.4 -1.2 2.0 -1.0 -0.4 -1.2 2.9 -1.5 1.8 -1.6 1.6 -1.2
Tinnitus: Yes, but not now, but have in the past 0.1 0.2 0.5 -0.2 0.3 -0.1 0.0 -0.3 -0.7 -0.6 0.1 -0.2 -0.6 -0.3
Qualifications: CSEs or equivalent 2.4 3.2 7.4 2.3 -0.0 2.1 2.6 2.7 0.3 0.0 0.9 2.4 0.4 2.1
Serious illness, injury or assault to yourself 0.4 0.5 1.9 -0.5 0.2 -1.0 -0.8 -0.0 -0.3 -1.4 0.8 -0.7 -0.4 -0.6
High blood pressure 3.9 10.9 21.8 -3.4 1.3 -2.8 -4.7 -3.8 3.6 -1.5 3.6 -3.3 3.8 -2.9
Hayfever, allergic rhinitis or eczema 1.1 2.3 5.2 -2.0 -1.3 -2.3 -1.1 -2.1 -0.3 0.6 0.1 -2.0 0.2 -2.0
Multivitamins +/- minerals 0.1 0.1 0.3 0.1 0.5 0.0 -0.1 0.3 0.0 0.6 0.2 -0.2 -0.2 -0.3
Stomach or abdominal pain in last month 0.5 0.6 2.8 -0.7 0.1 -0.8 -1.7 -1.0 0.8 -0.6 0.1 -0.6 0.3 0.1
Supplements: Glucosamine 0.4 0.6 1.5 -0.5 -0.8 -1.1 -0.8 -0.8 -1.2 0.6 -0.7 -0.5 -0.3 -0.6
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 1.1 0.0 0.2 0.0 -0.2 0.4 0.2 0.4 1.1 0.1 0.7 -0.0
Medication: Atenolol 0.5 0.6 3.6 -0.1 0.5 0.7 -1.0 0.0 0.3 1.9 0.3 0.4 0.4 0.5
Medication: Levothyroxine sodium 0.7 1.2 3.2 1.7 0.5 1.3 0.4 1.4 0.1 0.2 -0.2 1.8 -0.2 1.7
Sitting height 0.2 1.2 4.0 -1.6 -2.0 -1.3 -0.7 -1.2 -0.8 -0.2 -0.4 -1.5 0.2 -0.6
Chronic bronchitis/emphysema (father) 0.4 0.5 1.2 -1.0 -0.3 -0.8 -0.2 0.1 1.1 -1.0 0.1 -0.7 1.1 -0.5
High blood pressure (mother) 1.0 1.5 2.6 -1.4 0.7 -1.6 -0.0 -1.4 0.3 -0.2 1.5 -1.5 1.6 -1.5
Body mass index (BMI) 1.0 4.3 10.2 -2.1 -0.5 -2.5 -3.2 -2.5 0.8 -1.4 2.1 -2.4 1.1 -2.6
Impedance of leg (left) 2.3 11.3 24.3 4.2 1.9 4.6 3.7 4.9 -0.0 2.3 -0.8 4.5 -0.6 4.1
Leg predicted mass (left) 1.4 7.3 13.5 -3.4 -1.8 -3.6 -3.1 -3.6 0.1 -1.7 1.2 -3.7 0.9 -3.4
Trunk fat mass 0.5 2.3 6.4 -1.2 1.0 -1.3 -1.9 -1.3 1.4 -0.7 2.5 -1.4 1.6 -1.7
Waist circumference 0.9 3.3 8.1 -1.8 -0.8 -2.2 -2.8 -2.1 0.7 -1.4 1.4 -2.2 0.5 -2.5
Number of incorrect matches in round 0.4 0.7 3.2 0.1 1.8 1.0 -0.3 0.6 0.5 -0.7 0.8 0.7 0.3 1.2
Past tobacco smoking 1.4 2.5 6.2 -2.1 0.8 -1.6 -2.5 -2.0 0.7 -0.4 0.9 -2.1 0.6 -1.9
Alcohol usually taken with meals 0.7 1.2 3.4 -0.7 -0.0 -1.8 -1.1 -1.1 -0.2 -0.6 -0.8 -1.5 0.1 -1.9
Nervous feelings 0.6 1.2 3.3 0.6 1.2 1.8 0.7 1.5 0.6 0.9 0.7 1.2 0.9 1.3
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.5 -0.6 0.2 -0.7 0.7 -0.1 0.7 -0.1 0.3 -0.1 0.0 0.2
Hearing difficulty/problems with background noise 0.1 0.2 0.7 -0.0 0.1 0.4 0.3 0.4 0.2 0.9 -0.4 0.6 0.2 0.6
Hair/balding pattern: Pattern 2 0.2 0.2 0.7 -0.1 0.2 -0.2 -0.9 -0.7 -0.4 -0.3 0.5 -0.3 -0.3 -0.6
Had menopause 0.1 0.1 0.8 -0.2 0.2 0.2 0.9 0.0 0.5 0.6 0.2 0.1 0.1 0.2
Had other major operations 1.3 1.5 3.5 -1.7 -0.5 -1.9 -0.6 -1.7 -0.6 -1.2 -0.2 -1.6 -0.8 -1.6
Forced vital capacity (FVC) 0.1 0.3 1.1 0.4 -0.3 0.4 -1.1 0.5 -0.8 -0.1 0.2 0.5 0.3 0.7
Heel bone mineral density (BMD) T-score, automated (right) 1.7 3.9 7.9 -1.7 1.9 -1.5 -1.4 -2.2 2.8 -1.9 2.1 -2.1 1.9 -1.9
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.7 -0.8 1.3 -0.8 -0.4 -0.4 0.8 -0.2 0.7 -0.7 0.3 -0.8
Qualifications: None of the above 0.2 0.4 1.1 0.6 0.4 0.6 0.4 0.3 -0.4 0.2 -0.6 0.9 -0.7 1.0
Financial difficulties in last 2 years 0.8 1.1 3.3 -1.2 0.3 -0.8 -1.3 -1.0 0.6 1.0 1.8 -0.9 0.9 -0.9
Mouth/teeth dental problems 0.5 0.7 1.5 1.0 -0.1 0.7 0.1 1.0 -0.9 -0.6 -1.2 0.9 -0.9 1.1
Heart attack 1.0 1.3 4.4 -0.9 0.8 -0.8 -1.3 -0.2 2.1 -0.1 1.3 -0.9 1.8 -0.7
Allergy 0.6 1.5 4.0 1.5 2.0 1.6 0.4 1.5 0.8 -0.1 0.7 1.4 0.3 1.3
Pain all over the body in last month 0.2 0.2 0.5 0.2 -0.2 -0.1 0.3 0.4 -0.6 -0.7 -0.5 0.1 -0.7 -0.2
Diabetes (self-reported) 1.1 1.8 4.1 -1.4 1.4 -0.9 -1.3 -1.1 2.0 -0.0 1.9 -0.8 1.7 -0.7
Hayfever/allergic rhinitis (self-reported) 1.8 2.3 5.6 -2.4 -0.2 -2.3 -0.6 -2.0 1.1 -0.3 0.2 -2.2 0.5 -2.1
Medication: Ramipril 5.3 6.8 14.3 -2.3 2.6 -1.9 -2.4 -2.5 3.0 -2.2 3.3 -2.2 3.8 -2.0
Medication: Simvastatin 3.9 5.7 15.2 -2.3 2.0 -1.5 -2.5 -1.9 3.2 1.0 3.0 -1.8 3.9 -1.7
Fluid intelligence score 0.7 1.5 3.4 -1.8 -1.6 -1.6 0.7 -1.3 -1.1 -0.0 -0.4 -1.6 -0.3 -1.4
Illnesses of siblings 0.7 1.0 3.9 0.4 -1.7 -0.3 0.7 0.9 -1.2 -0.3 -1.1 0.0 -2.0 -0.3
Neuroticism score 0.5 1.1 2.8 0.3 1.6 0.9 -0.1 0.7 1.5 0.6 1.7 0.9 1.0 0.6
Weight 0.9 4.6 8.3 -2.4 -1.2 -2.7 -2.9 -2.7 0.5 -1.4 1.7 -2.7 1.1 -2.7
Impedance of arm (right) 1.5 6.9 15.6 2.6 4.0 2.7 3.1 3.6 1.8 1.7 1.4 2.7 1.7 2.4
Arm fat percentage (right) 0.5 2.1 5.1 -1.0 0.8 -1.3 -2.1 -1.1 1.2 -0.7 2.3 -1.3 1.7 -1.7
Trunk fat-free mass 1.4 7.9 15.4 -3.4 -3.9 -3.5 -2.9 -3.7 -0.9 -0.7 -0.6 -3.6 -0.3 -3.2
Hip circumference 2.3 10.1 17.5 -3.4 0.6 -3.3 -4.2 -3.7 2.8 -0.7 3.5 -3.6 3.2 -3.8
Time employed in main current job 3.7 4.3 11.4 -2.2 -0.1 -2.9 -2.8 -2.3 0.4 0.4 0.9 -2.9 0.6 -3.4
Alcohol intake versus 10 years previously 0.4 0.6 3.3 -0.0 0.7 0.9 -0.5 0.1 0.2 1.8 1.1 0.4 0.3 0.5
Father’s age at death 1.5 2.0 3.9 2.0 -1.1 1.0 1.5 1.8 -1.2 0.4 -1.4 1.6 -1.5 1.6
Worrier / anxious feelings 0.1 0.2 1.0 -0.2 1.0 0.8 -0.4 -0.1 0.4 0.7 0.2 0.2 0.2 0.1
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.5 0.1 0.6 -0.5 0.3 -0.1 -0.5 -0.7 -0.0 0.0 -0.6 0.0
Falls in the last year 3.0 4.0 6.5 2.1 -2.0 2.2 1.9 2.5 -2.4 -1.0 -1.2 2.2 -1.9 2.1
Hair/balding pattern: Pattern 3 0.2 0.2 1.3 0.2 0.3 -0.0 1.2 0.9 0.0 -0.1 -0.2 0.1 -0.2 0.3
Number of live births 0.3 0.4 1.3 0.4 -0.1 0.4 -1.1 0.3 -0.9 0.3 -1.2 0.6 -0.8 0.4
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 1.5 1.1 -0.6 0.9 -0.4 1.2 -1.2 0.3 -0.4 1.2 -0.3 1.2
Pulse rate 2.1 3.6 7.3 1.8 -1.9 1.1 2.4 1.6 -1.5 -0.7 -2.7 1.7 -2.5 1.8
Happiness 0.8 1.0 3.2 0.6 0.2 0.7 1.8 1.4 0.7 -1.4 -0.3 0.9 -0.1 1.3
Noisy workplace 0.4 0.5 2.7 -0.1 -1.6 -0.3 -0.8 -1.0 0.3 -0.8 -0.6 -0.2 -0.2 -0.2
Qualifications: A levels/AS levels or equivalent 0.9 2.1 3.7 -1.9 0.2 -1.8 -0.2 -1.6 0.8 0.9 1.2 -1.8 1.9 -1.8
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 3.0 0.2 -0.9 -1.1 0.4 -0.1 -1.1 -0.5 -1.0 -0.4 -1.7 -0.9
Mouth/teeth dental problems: Dentures 0.7 1.2 3.1 -1.3 0.2 -1.0 -1.2 -1.8 0.8 -0.3 0.7 -1.5 0.4 -1.5
Asthma 0.2 0.5 1.0 -0.7 -0.7 -0.6 -0.9 -1.0 -0.1 -0.0 -0.3 -0.9 -0.0 -0.9
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.9 0.5 -0.7 0.0 0.3 0.6 -0.3 -1.0 -0.3 0.2 -0.6 -0.2
Medication: Cholesterol lowering 2.3 3.5 9.4 -1.9 1.1 -1.6 -1.1 -1.6 2.8 0.7 2.3 -1.6 3.1 -1.4
Depression (self-reported) 0.6 0.7 1.7 -1.0 1.1 -0.6 0.7 -0.5 0.7 -0.4 1.3 -0.9 0.9 -0.6
Medication: Lansoprazole 1.7 1.9 3.1 -1.5 0.6 -1.4 -0.4 -1.0 1.2 -1.8 1.8 -1.5 1.8 -1.5
Prospective memory result 0.6 0.7 1.8 1.3 1.1 1.3 -0.0 0.7 -0.3 0.0 0.5 1.0 -0.2 0.9
Lung cancer (father) 2.5 3.0 6.0 2.0 -0.4 2.2 2.4 2.4 -0.8 0.9 -0.6 2.4 -0.5 2.0
Illnesses of mother 1.5 1.9 12.0 0.3 -1.8 0.8 -0.0 0.3 -0.3 3.5 -1.4 0.7 -1.3 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.5 1.4 0.4 -0.7 0.3 -1.0 0.7 -1.0 1.2 -0.3 0.6 -0.5 0.7
Pulse wave Arterial Stiffness index 0.1 0.1 0.8 0.2 0.1 0.1 0.0 0.1 -0.1 0.3 0.1 0.3 -0.9 -0.1
Impedance of arm (left) 1.5 7.0 21.1 2.3 4.6 2.4 2.9 3.4 2.2 1.0 1.9 2.5 2.0 2.2
Arm fat mass (right) 0.9 3.6 7.2 -1.9 -0.1 -2.1 -2.7 -2.1 1.0 -1.1 2.1 -2.2 1.5 -2.5
Trunk predicted mass 1.4 8.0 15.5 -3.5 -3.9 -3.5 -2.8 -3.7 -0.9 -0.9 -0.7 -3.7 -0.3 -3.2
Standing height 0.0 0.5 1.9 -0.9 -1.4 -0.7 0.2 -0.6 -0.5 -0.0 -0.4 -0.9 0.3 -0.4
Length of working week for main job 0.8 0.9 5.2 -0.5 1.1 -0.7 -2.3 -0.8 0.3 0.3 0.2 -0.9 -0.4 -1.0
Exposure to tobacco smoke at home 2.3 2.6 6.5 2.5 -0.4 2.2 0.8 2.0 -0.6 -1.2 -1.0 2.2 -1.4 1.7
Breastfed as a baby 0.6 0.7 1.7 0.6 -0.7 0.3 0.3 0.1 -1.3 1.1 -1.2 0.7 -1.2 0.4
Tense / ‘highly strung’ 0.7 1.1 2.5 1.2 0.5 1.1 1.3 1.6 0.5 -0.9 0.4 1.4 0.3 1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 2.0 -0.9 -0.4 -1.1 1.4 -0.3 -0.8 0.3 -0.1 -0.8 -0.7 -0.7
Hair/balding pattern: Pattern 4 0.2 0.4 0.9 -0.2 0.6 -0.5 0.9 -0.0 1.0 -0.7 0.3 -0.5 0.9 -0.8
Birth weight of first child 0.2 0.4 1.3 0.5 -1.1 0.3 0.6 0.4 -0.2 -1.0 -0.4 0.6 0.2 0.9
Peak expiratory flow (PEF) 0.9 2.0 3.3 1.7 -1.1 1.2 0.6 1.6 -1.8 0.0 -1.5 1.7 -1.3 1.8
Pulse wave reflection index 2.2 2.7 6.0 -1.9 1.4 -0.6 -2.2 -1.9 0.9 -0.9 2.4 -1.5 1.7 -1.6
Ever highly irritable/argumentative for 2 days 0.6 0.7 5.4 -0.2 0.4 -0.3 -0.1 0.6 -0.5 2.3 -0.5 0.5 -0.8 0.7
Loud music exposure frequency 2.5 2.7 5.9 2.3 -1.0 1.9 1.5 2.4 -1.2 -0.2 -0.6 2.4 -0.7 2.1
Qualifications: O levels/GCSEs or equivalent 2.0 3.2 6.6 -2.5 -0.2 -2.2 -1.2 -2.2 1.1 0.8 1.0 -2.4 1.5 -2.6
Mouth/teeth dental problems: Bleeding gums 1.8 2.4 8.0 -0.7 1.5 -0.1 -0.6 -0.5 2.8 1.1 2.3 -0.6 2.5 -1.2
Blood clot in the leg (DVT) 1.7 2.1 5.3 -0.0 -1.9 0.7 1.9 0.9 -2.3 -0.2 -1.8 0.6 -2.3 1.0
Medication: Paracetamol 0.8 1.3 2.9 1.3 0.1 1.3 0.1 1.7 -1.5 1.3 -0.3 1.4 -0.7 1.2
Headache pain in last month 0.5 0.9 4.8 -0.0 -0.6 0.0 0.5 0.6 -1.0 2.2 -0.8 0.4 -1.2 0.9
Medication for cholesterol, blood pressure or diabetes 1.4 2.3 7.1 1.1 -1.1 0.8 1.1 1.3 -2.6 -0.1 -2.0 0.9 -2.7 0.7
Glaucoma (self-reported) 0.3 0.4 0.7 0.2 0.7 0.7 0.7 0.2 -0.1 -0.4 0.8 0.8 0.5 0.6
Gout (self-reported) 0.2 0.2 0.5 0.3 0.7 0.5 -0.0 0.2 -0.5 0.7 0.4 0.5 -0.1 0.7
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 0.8 0.7 0.9 0.7 -0.3 0.6 0.5 0.5 0.0 0.8 0.2 0.7
Medication: Amlodipine 2.4 3.3 9.3 -1.9 1.3 -1.5 -1.4 -1.6 3.1 -0.0 1.9 -1.8 2.4 -1.5
Medication: Ventolin 100micrograms inhaler 1.0 1.3 3.4 0.0 1.4 0.3 -1.6 -0.7 1.8 0.3 1.8 -0.1 1.7 -0.2
Birth weight 2.3 5.0 14.0 0.8 -2.9 -0.1 1.4 0.6 -3.7 -1.9 -3.5 0.2 -3.7 0.2
Chronic bronchitis/emphysema (mother) 2.2 2.5 4.2 1.8 -0.7 1.7 1.6 2.0 -1.5 -1.7 -0.9 1.7 -1.3 1.9
High blood pressure (siblings) 1.1 1.6 3.8 -0.7 0.9 -0.5 -1.8 -1.5 1.7 -1.2 1.1 -0.8 1.9 -0.9
Forced vital capacity (FVC), Best measure 0.1 0.4 2.9 -0.3 0.2 -0.1 -1.7 0.0 -0.1 0.6 0.6 -0.1 0.6 0.1
Body fat percentage 0.4 1.5 6.8 -0.2 1.7 -0.4 -1.1 -0.2 1.5 -0.4 2.6 -0.4 1.5 -0.9
Leg fat percentage (right) 0.2 0.6 3.1 0.5 0.3 0.0 -1.1 0.2 0.8 -0.6 1.8 0.2 0.6 -0.3
Arm fat-free mass (right) 1.2 5.9 11.1 -3.0 -3.2 -3.0 -2.5 -3.3 -0.9 -1.2 -0.3 -3.1 -0.5 -2.7
Exposure to tobacco smoke outside home 0.6 0.8 4.1 0.5 -2.0 0.2 -0.8 -0.0 -0.7 0.3 -0.7 0.6 -1.5 0.6
Comparative body size at age 10 0.5 1.4 3.5 -1.2 -0.0 -1.8 -0.4 -1.6 0.3 -0.2 1.0 -1.5 1.0 -1.9
Number of full brothers 0.5 0.6 2.8 -0.3 -0.3 -0.3 -0.2 -0.8 1.3 0.2 1.1 -0.2 1.7 -0.6
Worry too long after embarrassment 0.8 1.3 4.2 0.7 1.0 1.8 0.4 1.6 -0.3 0.8 0.4 1.6 -0.0 2.1
Seen a psychiatrist for nerves, anxiety, tension or depression 2.1 2.7 5.7 1.3 1.8 2.0 1.9 1.8 -0.0 1.9 0.0 2.2 -0.1 2.4
Wheeze or whistling in the chest in last year 0.3 0.6 1.1 1.0 0.5 0.3 0.6 1.0 -0.6 -0.5 -1.0 0.8 -0.5 0.9
Number of children fathered 0.2 0.2 0.7 0.0 -0.8 -0.8 0.7 -0.3 -0.2 0.5 -0.0 -0.4 -0.1 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.6 4.6 1.1 2.0 1.4 2.1 1.2 -0.0 1.3 -0.1 1.3 -0.4 1.2
Age at first live birth 0.5 0.9 2.1 -1.0 0.4 -1.1 0.3 -0.7 0.8 0.0 1.5 -1.2 1.2 -0.8
Pulse wave peak to peak time 0.1 0.1 0.9 -0.2 0.0 -0.1 0.1 -0.1 0.1 -0.2 0.0 -0.3 0.9 0.2
Health satisfaction 0.5 0.6 1.7 0.3 1.2 -0.4 1.3 1.1 0.9 -0.7 0.8 0.1 0.5 0.1
Shortness of breath walking on level ground 4.3 5.2 9.1 -3.0 0.4 -2.5 -2.9 -2.9 1.2 -1.7 1.6 -2.8 1.6 -2.7
Qualifications: College or University degree 0.4 1.2 2.7 -1.5 -0.3 -1.3 -1.1 -1.4 0.1 -0.5 -0.4 -1.6 0.6 -1.5
Eye problems/disorders: None of the above 0.6 0.6 1.6 0.2 -1.2 0.6 0.3 0.3 -1.1 1.3 -1.1 0.3 -0.8 0.6
Mouth/teeth dental problems: Loose teeth 0.8 0.9 2.2 -1.4 -0.2 -1.3 -0.0 -1.3 -0.3 -0.9 0.2 -1.5 -0.2 -1.3
Emphysema/chronic bronchitis 0.7 0.8 3.8 0.5 -0.9 -0.0 -0.3 0.2 -1.1 -2.0 -0.7 0.2 -1.2 0.4
Medication for pain relief, constipation, heartburn 0.8 1.3 2.6 -1.2 0.3 -1.4 -0.7 -1.6 1.2 -1.1 0.8 -1.6 0.7 -1.5
Neck or shoulder pain in last month 0.4 0.6 1.4 0.7 0.2 0.2 0.2 1.1 -1.2 -0.0 -0.9 0.8 -1.2 0.8
Medication: Blood pressure 1.9 3.3 10.5 -1.3 1.8 -0.9 -1.6 -1.8 3.2 -0.6 2.1 -1.2 2.7 -0.8
Angina (self-reported) 1.6 2.1 6.4 -1.5 1.1 -0.5 -0.9 -1.3 2.1 0.7 2.0 -1.0 2.5 -1.1
Migraine (self-reported) 0.2 0.3 0.9 0.6 -0.4 0.4 0.9 0.9 0.2 -0.1 0.1 0.5 0.5 0.2
Medication: Ibuprofen 0.3 0.4 1.5 0.9 -0.4 0.4 0.8 1.2 -0.1 -0.5 -0.3 0.7 -0.5 0.1
Medication: Allopurinol 0.4 0.6 2.4 -0.5 1.3 -0.0 -0.4 -0.2 0.3 0.1 1.6 -0.4 1.3 -0.1
Medication: Omeprazole 3.2 3.9 5.8 2.0 -1.5 2.1 2.1 2.4 -2.1 -0.2 -1.6 2.4 -1.7 2.4
Medication: Seretide 50 evohaler 0.5 0.5 2.1 0.3 -0.9 -1.2 -0.7 0.3 -0.2 -0.2 -1.0 -0.1 -1.5 0.1
Mean time to correctly identify matches 0.8 1.4 7.1 -0.4 1.8 0.6 -1.8 -0.7 0.6 2.7 0.2 -0.3 0.7 -0.6
Heart disease (mother) 0.3 0.3 1.0 -0.5 0.7 -0.3 -0.4 -0.9 -0.3 -1.0 0.3 -0.5 0.5 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.7 4.4 8.4 2.4 -1.0 2.6 0.2 2.2 -2.6 -0.5 -2.1 2.6 -1.8 2.9
Whole body fat mass 0.4 1.8 4.4 -1.1 0.4 -1.3 -1.9 -1.2 1.0 -0.8 2.1 -1.4 1.2 -1.6
Leg fat mass (right) 0.4 1.6 3.9 -0.9 -0.3 -1.3 -2.0 -1.2 0.5 -1.2 1.8 -1.2 0.7 -1.4
Arm predicted mass (right) 1.2 6.0 11.1 -3.0 -3.2 -3.1 -2.4 -3.3 -0.9 -1.0 -0.4 -3.2 -0.4 -2.9
Pulse rate, automated reading 1.7 5.6 14.7 2.1 -2.5 1.6 1.8 1.9 -3.1 -0.1 -3.1 2.1 -3.8 1.8
Alcohol intake frequency. 1.7 3.9 10.6 -2.1 1.1 -1.1 -2.2 -2.0 2.2 3.2 2.1 -1.4 1.8 -1.5
Comparative height size at age 10 0.2 0.9 3.4 0.1 1.0 0.8 -0.2 0.2 1.2 1.1 1.5 0.1 1.9 0.1
Number of full sisters 0.3 0.3 0.7 0.7 -0.2 -0.4 -0.3 0.7 -0.8 0.2 -0.6 0.5 -0.8 0.5
Suffer from ‘nerves’ 0.6 1.0 2.0 -1.4 -0.4 -1.1 -0.5 -0.4 1.3 -0.9 0.9 -1.0 1.4 -1.1
Overall health rating 0.2 0.5 2.4 -0.5 1.5 -0.2 -0.2 0.1 0.6 -1.1 1.2 -0.2 -0.2 -0.0
Chest pain or discomfort 0.3 0.4 3.3 -0.4 0.0 0.4 -0.3 -0.0 0.3 -1.8 0.7 -0.0 0.5 0.2
Had major operations 0.3 0.4 1.0 -0.2 1.0 -0.8 0.4 -0.3 0.3 -0.7 0.7 -0.7 -0.1 -0.7
Age at last live birth 0.3 0.5 2.3 -0.0 0.3 -0.3 0.1 0.2 0.9 0.0 1.5 -0.2 1.5 -0.1
Family relationship satisfaction 0.5 0.6 4.2 -0.9 0.3 -0.6 0.7 -0.1 0.7 -2.0 0.1 -0.8 0.2 0.0
Leg pain on walking 1.0 1.2 2.6 -1.6 1.2 -0.8 -1.6 -1.4 0.2 1.2 1.0 -1.0 0.3 -0.9
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 1.0 0.4 -0.4 1.0 -0.9 0.5 -0.5 0.1 -0.5 0.3 -0.9 0.2
Commuting to job workplace: Car/motor vehicle 0.9 1.1 2.2 1.3 1.4 1.4 0.1 0.7 -0.1 -0.8 1.0 1.4 -0.1 1.5
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 1.4 -0.6 -0.4 0.0 -0.8 -0.9 0.0 -0.1 -1.2 -0.5 0.1 -0.2
Medication: Aspirin 0.5 0.6 3.5 -0.1 1.9 0.4 -0.3 -0.3 0.8 0.5 0.9 0.4 0.9 0.6
Supplements: Vitamin C 0.8 0.9 4.9 -0.1 2.2 -0.3 -0.3 -0.4 0.9 1.5 0.7 -0.1 1.0 -0.5
Knee pain experienced in last month 1.0 1.5 3.5 -1.9 0.0 -1.2 -1.4 -1.8 0.7 -0.3 1.3 -1.5 0.3 -1.3
Hypertension (Self-reported) 3.2 8.8 18.9 -3.2 1.4 -2.5 -4.3 -3.4 3.1 -1.1 3.1 -3.1 3.2 -2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 1.2 -0.0 -0.0 -0.0 0.3 0.6 -0.9 -1.1 -0.2 -0.1 -0.8 -0.1
Illnesses of father: Heart disease 3.6 5.0 10.0 -2.6 0.9 -2.9 -1.8 -3.2 0.6 -2.0 1.1 -3.0 1.4 -3.0
Illnesses of siblings: Diabetes 0.2 0.3 1.0 0.4 0.6 0.5 0.7 -0.2 0.3 -0.5 1.0 0.3 0.6 0.4
Smoking status: Previous 1.5 2.2 6.2 2.2 -0.3 1.5 2.5 1.9 0.3 0.2 0.1 2.1 0.4 1.7
Forced expiratory volume in 1-second (FEV1), predicted 1.9 3.9 7.0 2.1 -1.3 2.3 1.8 2.6 -1.9 1.5 -1.4 2.2 -1.1 2.5
Whole body fat-free mass 1.4 7.8 14.2 -3.5 -3.3 -3.6 -3.1 -3.8 -0.7 -1.2 -0.0 -3.7 0.0 -3.3
Leg fat-free mass (right) 1.5 7.8 14.4 -3.5 -2.1 -3.7 -3.3 -3.7 -0.1 -1.7 1.1 -3.8 0.7 -3.5
Arm fat percentage (left) 0.6 2.5 6.1 -1.1 1.1 -1.5 -2.1 -1.2 1.4 -1.2 2.5 -1.4 1.7 -1.8
Average weekly red wine intake 0.1 0.1 0.4 -0.2 -0.1 -0.4 0.2 -0.1 0.0 -0.6 -0.4 -0.4 -0.1 -0.6
Handedness (chirality/laterality): Left-handed 3.0 3.6 8.5 -1.9 0.6 -1.5 -2.4 -2.3 2.9 1.1 1.9 -1.5 2.3 -1.2
Mood swings 0.2 0.4 2.5 -0.2 0.4 0.3 -0.7 0.0 -0.1 1.6 0.9 0.2 0.1 0.0
Loneliness, isolation 0.8 1.2 2.6 -0.9 1.5 -1.2 -0.6 -0.2 1.6 -0.5 1.6 -0.8 1.2 -0.7
Long-standing illness, disability or infirmity 0.9 1.4 2.9 -1.5 -0.1 -1.6 -0.5 -0.6 1.0 -1.1 1.3 -1.7 0.8 -1.7
Ever had bowel cancer screening 0.6 0.7 2.2 0.8 0.6 0.6 1.5 0.5 -0.8 0.9 -0.8 1.0 -0.4 0.8
Diabetes diagnosed by doctor 0.9 1.5 2.9 -1.3 1.2 -1.2 -1.1 -0.8 1.7 -0.6 1.7 -0.9 1.6 -0.8
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 3.5 -0.8 0.5 -0.6 -0.1 -1.1 0.9 -1.9 1.5 -1.1 0.9 -1.0
Friendships satisfaction 0.7 0.9 4.6 -0.5 1.1 -0.7 -0.1 0.1 1.3 -2.1 0.3 -0.7 0.1 -0.6
Qualifications: nursing, teaching 0.4 0.5 2.9 -0.4 -1.7 -0.5 -1.0 0.2 -0.6 0.5 -0.4 -0.5 0.4 -0.6
Commuting to job workplace: Walk 1.5 1.6 4.8 -1.4 -1.3 -2.1 0.5 -1.1 -0.0 -0.3 -0.7 -1.7 0.0 -2.2
Eye problems/disorders: Cataract 1.6 1.9 4.5 -1.5 -0.4 -2.1 -1.2 -1.7 0.1 -1.6 -0.7 -1.7 -0.5 -1.9
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 2.6 1.4 -0.6 0.7 1.6 1.1 -0.8 -1.3 -0.0 1.2 -0.2 1.3
Medication for cholesterol 2.2 3.4 6.8 2.1 -0.6 2.1 2.2 2.6 -1.3 0.8 -1.3 2.1 -1.7 2.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.2 0.3 -0.2 -0.5 -0.2 -0.5 0.1 -0.3 0.6 -0.3 0.4 -0.5 0.3
Back pain experienced in last month 0.4 0.6 2.4 -0.8 -0.9 -1.5 0.5 0.4 -0.7 0.1 0.0 -1.0 0.0 -1.0
Mineral and other dietary supplements 0.8 1.0 2.1 0.6 -1.4 1.1 0.7 1.1 -1.4 0.2 -0.9 0.8 -1.3 0.9
Breast cancer (self-reported) 0.1 0.2 0.5 0.4 0.5 0.2 -0.1 -0.0 0.7 -0.0 0.4 0.1 0.7 -0.3
Asthma (self-reported) 0.3 0.6 1.3 -0.9 -0.4 -0.9 -1.0 -1.2 0.3 -0.2 0.1 -1.1 0.4 -1.2
Osteoporosis (self-reported) 1.5 1.9 5.2 0.9 -1.0 1.0 0.8 1.0 -2.3 0.4 -1.4 1.1 -2.3 1.7
Osteoarthritis (self-reported) 0.7 0.9 2.1 -1.3 -0.1 -1.2 -0.8 -1.4 0.4 -0.8 1.1 -1.2 0.2 -1.0
Medication: Aspirin 0.3 0.4 2.3 -0.3 1.5 0.2 -0.2 -0.2 0.6 0.3 0.6 0.3 0.8 0.3
Medication: Gliclazide 2.8 3.2 7.8 -1.2 2.6 -0.7 -1.9 -1.1 2.7 1.6 2.8 -0.5 1.9 -0.6
Illnesses of father: None of the above (group 1) 1.5 1.8 3.8 1.4 -1.0 1.7 0.8 1.7 -0.4 1.8 -0.4 2.0 -0.8 1.7
Smoking status: Current 0.5 0.8 3.5 -0.2 -0.5 0.1 -0.1 0.0 -1.5 -0.3 -1.6 -0.1 -1.9 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.3 1.0 0.3 0.8 0.2 0.8 -1.2 0.3 -1.1 0.9 -0.6 0.8
Whole body water mass 1.4 8.0 14.5 -3.5 -3.3 -3.6 -3.0 -3.8 -0.7 -1.3 -0.0 -3.8 0.0 -3.4
Leg predicted mass (right) 1.5 8.0 14.8 -3.5 -2.1 -3.7 -3.4 -3.8 -0.1 -1.8 1.1 -3.9 0.7 -3.5
Arm fat mass (left) 1.0 4.0 7.9 -1.9 0.2 -2.3 -2.8 -2.1 1.1 -1.3 2.3 -2.3 1.5 -2.6
Number of self-reported non-cancer illnesses 4.9 8.6 16.0 -4.0 1.1 -3.4 -3.1 -3.7 2.0 -0.3 2.1 -3.8 2.3 -3.7
Average weekly champagne plus white wine intake 0.2 0.2 1.5 -0.2 0.0 -0.5 -0.2 -0.5 0.3 1.2 0.0 -0.2 0.2 -0.4
Miserableness 0.3 0.5 2.4 0.5 0.7 0.6 0.5 0.5 0.7 1.5 0.6 0.8 -0.2 0.3
Guilty feelings 0.9 1.4 8.0 -0.3 2.8 0.2 -1.2 -0.2 0.7 0.6 1.7 -0.0 1.4 0.3
Wears glasses or contact lenses 0.3 0.3 1.7 -0.4 -0.0 -0.8 1.3 0.0 -0.0 -0.2 -0.6 -0.3 -0.5 -0.2
Ever taken oral contraceptive pill 0.1 0.1 0.2 -0.2 -0.0 0.1 -0.0 -0.2 -0.3 0.4 0.0 -0.1 0.4 0.4
Hearing aid user 0.6 0.6 2.5 0.3 -0.7 0.2 1.6 1.3 -0.5 -1.2 -0.3 0.2 -0.4 0.0
Mother’s age at death 1.1 1.4 2.9 1.1 -1.2 0.7 1.5 0.8 -1.5 0.8 -1.7 1.1 -1.2 1.0
Financial situation satisfaction 0.2 0.2 0.7 -0.3 -0.8 -0.1 -0.3 -0.2 0.1 -0.0 0.6 0.1 0.6 0.7
Tinnitus: Yes, now most or all of the time 0.3 0.4 1.4 -0.7 0.4 -0.4 -0.3 -0.1 0.0 1.2 0.1 -0.6 0.9 -0.8
Commuting to job workplace: Public transport 0.6 0.7 2.6 -0.7 -0.3 -0.2 -0.2 -0.4 1.4 -0.5 0.7 -0.9 1.6 -0.8
Eye problems/disorders: Glaucoma 0.6 0.7 1.9 -1.4 0.3 -0.6 -0.6 -0.9 0.1 -0.6 1.3 -0.8 0.9 -1.0
Medication: Blood pressure 3.1 5.8 9.6 -2.8 0.7 -2.6 -3.1 -2.9 1.8 -0.7 2.0 -2.7 2.5 -3.1
Pain type(s) experienced in last month: Hip pain 1.4 1.7 3.3 1.6 0.5 1.8 1.3 1.8 -0.8 0.8 -0.5 1.6 -1.5 1.4
Supplements: Fish oil (including cod liver oil) 1.3 1.7 3.2 -0.9 1.1 -1.8 -1.1 -1.5 1.7 -1.1 1.0 -1.3 1.3 -1.3
High cholesterol (Self-reported) 2.0 3.6 7.2 -2.0 0.6 -1.9 -1.6 -2.1 2.6 -0.4 2.0 -1.8 2.7 -1.8
Medication: Bendroflumethiazide 2.6 3.9 10.2 -2.2 1.6 -1.6 -3.2 -2.4 1.9 0.9 1.3 -1.9 2.0 -1.9
Medication: Paracetamol 1.3 2.0 4.8 1.4 -0.5 1.2 0.5 1.9 -2.2 1.9 -0.8 1.5 -1.4 1.2
Medication: Lisinopril 3.1 4.0 7.3 -2.0 0.9 -2.0 -2.1 -1.8 2.7 -0.5 2.5 -1.9 2.6 -1.8
Medication: Atorvastatin 0.2 0.2 0.7 0.1 -0.8 -0.3 -0.4 -0.2 0.7 -0.8 -0.1 0.0 -0.0 -0.1
Illnesses of father: High blood pressure 0.6 0.7 1.6 -0.9 0.9 -0.7 -0.5 -0.9 1.1 -0.5 1.3 -0.7 0.9 -0.6
Alcohol drinker status: Never 1.6 1.9 3.9 -2.0 1.1 -0.8 -0.8 -1.8 1.1 1.2 1.3 -1.4 1.4 -1.8
Ever smoked 1.3 2.3 3.3 1.4 -1.3 1.4 1.6 1.4 -1.7 1.2 -1.6 1.8 -1.3 1.7
Basal metabolic rate 1.3 7.2 12.9 -3.3 -2.8 -3.4 -3.2 -3.6 -0.3 -1.3 0.5 -3.6 0.4 -3.3
Leg fat percentage (left) 0.1 0.4 2.4 0.4 0.0 -0.0 -1.0 0.3 0.5 -0.7 1.6 0.1 0.4 -0.5
Arm fat-free mass (left) 1.2 6.2 11.0 -3.0 -3.3 -3.0 -2.7 -3.3 -0.6 -1.0 -0.3 -3.2 -0.2 -3.0
Number of operations (self-reported) 1.2 1.8 4.1 -1.6 -1.5 -2.0 0.0 -1.6 -1.0 -0.7 -0.7 -1.6 -1.1 -1.6
Average weekly beer plus cider intake 3.3 4.7 10.4 3.0 -0.3 2.6 2.0 2.9 -1.2 -0.3 -1.2 3.2 -1.4 3.0
Irritability 0.2 0.4 1.4 0.8 0.0 0.5 0.3 1.2 -0.3 -0.3 0.7 0.8 -0.2 0.6
Risk taking 1.5 2.1 3.3 1.7 -1.8 1.4 0.7 1.5 -1.6 -0.8 -1.5 1.6 -1.7 1.3
Ever had prostate specific antigen (PSA) test 1.0 1.2 2.2 1.5 -0.1 1.2 1.3 1.1 -0.4 0.9 -1.3 1.5 -0.3 1.3
Fractured/broken bones in last 5 years 2.1 2.7 7.1 1.8 -1.2 1.1 2.7 2.2 -0.9 -0.2 -0.8 2.0 -1.5 1.8
Age started oral contraceptive pill 1.3 1.7 4.0 2.0 0.2 1.6 0.5 1.7 -0.0 -1.8 -0.3 1.6 -0.3 1.7
Diastolic blood pressure, automated reading 0.1 0.4 3.3 -0.0 -0.0 0.2 -1.8 -0.4 -0.6 -0.9 0.4 -0.0 -0.1 0.3
Ever depressed for a whole week 1.2 1.5 4.2 -1.8 0.1 -2.0 -1.0 -1.4 -0.0 -1.2 0.1 -1.8 -0.2 -1.4
Unable to work because of sickness or disability 0.8 1.0 4.1 0.0 -0.8 -0.5 -0.8 0.1 -1.7 -0.5 -1.4 -0.3 -2.0 -0.2
Commuting to job workplace: Cycle 0.6 0.7 2.5 0.2 -1.5 0.9 0.1 0.4 -0.8 0.2 -1.6 0.5 -1.0 0.3
Myopia 0.5 0.8 2.1 -1.1 -0.5 -1.5 -0.3 -1.0 0.0 -1.0 0.2 -1.2 0.5 -0.9
Vascular/heart problems diagnosed by doctor 4.0 10.8 21.8 3.3 -1.9 2.5 4.7 3.6 -4.0 1.0 -3.7 3.0 -4.2 2.5
Cholesterol lowering medication 2.5 3.6 8.4 -1.4 1.7 -1.3 -2.5 -1.4 2.5 -0.9 2.4 -1.3 2.9 -1.5
Medication: Omeprazole (e.g. Zanprol) 3.2 3.9 7.1 1.9 -1.6 2.1 2.4 2.7 -2.0 -0.7 -1.5 2.2 -1.5 2.2
Pain experienced in last month 0.1 0.2 0.6 0.8 -0.0 0.4 0.2 -0.5 -0.2 -0.4 -0.5 0.3 -0.5 -0.1
Supplements: Calcium 0.5 0.5 2.5 0.6 -0.2 0.2 1.6 0.5 -0.3 1.0 -0.7 0.8 -0.5 0.5
Basal cell carcinoma (self-reported) 0.5 0.7 1.4 -0.4 -1.1 -1.1 -0.2 -0.5 -1.1 0.5 -0.8 -0.6 -1.2 -0.7
Heart attack/myocardial infarction (self-reported) 0.6 0.8 3.5 -0.6 0.4 -0.6 -1.0 0.1 1.9 -0.1 1.1 -0.6 1.4 -0.5
Deep venous thrombosis (DVT) (self-reported) 1.1 1.5 4.2 -0.5 -1.6 0.5 1.4 0.5 -1.9 -0.1 -1.4 0.2 -2.0 0.7
Heart disease (siblings) 0.3 0.4 1.4 -0.4 0.8 -0.2 -0.4 -1.0 0.7 -0.2 0.7 -0.3 1.2 0.2
Alcohol drinker status: Previous 0.8 1.0 3.1 -1.0 0.3 -0.7 -1.4 -1.0 0.6 1.8 1.3 -0.6 0.2 -0.8
Pack years of smoking 0.3 0.5 1.7 0.6 -0.5 0.0 -0.1 0.8 -0.7 -0.6 -1.3 0.3 -1.2 0.2
Impedance of whole body 2.1 10.7 22.5 3.8 3.9 4.0 3.7 4.7 1.3 1.8 0.7 4.1 0.9 3.6
Leg fat mass (left) 0.4 1.4 3.3 -0.8 -0.4 -1.2 -1.8 -1.1 0.5 -1.2 1.8 -1.2 0.7 -1.4
Arm predicted mass (left) 1.3 6.5 12.5 -3.0 -3.5 -3.1 -2.7 -3.3 -0.7 -1.1 -0.4 -3.2 -0.3 -3.0