TWAS hub - KCTD13

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0562	0.0368	0.0062	0.013	NA	0.017	NA	0.021	0.0290	NA	0.017	NA	0.0080
2	GTEx	Skin Sun Exposed Lower leg	0.0550	0.0280	0.0028	-0.002	NA	0.011	NA	0.004	0.5700	NA	0.039	NA	0.1500
3	TCGA	Prostate Adenocarcinoma	0.0227	0.0148	0.0064	0.022	0.013	0.010	NA	0.019	0.0021	0.014	0.028	NA	0.0039

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Weight	20.6	101.4	187.7	8.5	6.7	13.7
Waist circumference	20.4	74.6	151.3	5.9	6.1	12.3
Basal metabolic rate	20.1	111.5	196.0	9.8	6.5	14.0
Leg fat-free mass (right)	19.7	105.0	176.9	9.7	6.7	13.3
Leg predicted mass (right)	19.7	105.2	176.9	9.7	6.7	13.3
Arm fat mass (right)	19.4	79.9	153.8	6.7	6.4	12.4
Leg predicted mass (left)	19.1	101.0	174.2	9.3	6.5	13.2
Arm fat mass (left)	19.1	78.6	151.3	6.5	6.5	12.3
Leg fat-free mass (left)	18.9	100.1	171.6	9.3	6.6	13.1
Whole body water mass	18.5	105.4	182.2	9.8	6.2	13.5
Whole body fat-free mass	18.4	104.9	179.6	9.9	6.2	13.4
Arm predicted mass (left)	18.4	93.6	174.2	8.7	5.5	13.2
Arm fat-free mass (left)	18.2	92.1	171.6	8.6	5.6	13.1
Number of incorrect matches in round	18.1	30.1	37.6	-5.4	-4.8	-6.1
Hip circumference	17.6	75.7	146.4	6.8	5.8	12.1
Body mass index (BMI)	17.1	73.1	141.6	5.4	6.9	11.9
Arm predicted mass (right)	17.1	87.5	156.2	9.0	5.1	12.5
Arm fat-free mass (right)	16.8	86.4	156.2	8.7	5.2	12.5
Trunk fat-free mass	16.5	94.5	158.8	9.7	5.6	12.6
Trunk predicted mass	16.5	94.5	158.8	9.7	5.5	12.6
Blood Red Count	15.5	149.4	196.0	-9.4	-12.8	-14.0
Impedance of leg (right)	14.8	71.6	121.0	-6.3	-7.3	-11.0
Whole body fat mass	14.8	62.0	123.2	5.7	5.5	11.1
Leg fat mass (left)	14.3	55.9	114.5	5.2	5.1	10.7
BMI	14.0	81.4	148.8	6.3	7.5	12.2
Impedance of whole body	13.4	68.2	121.0	-6.2	-6.7	-11.0
Impedance of leg (left)	13.3	64.5	106.1	-5.9	-7.3	-10.3
Leg fat mass (right)	13.3	51.7	104.0	5.1	5.0	10.2
Trunk fat mass	12.7	54.3	108.2	5.6	4.9	10.4
Arm fat percentage (right)	11.5	45.2	88.9	4.3	5.3	9.4
Arm fat percentage (left)	11.1	44.1	86.7	4.4	5.2	9.3
Impedance of arm (left)	9.9	46.0	87.4	-5.0	-5.1	-9.3
Impedance of arm (right)	9.0	42.0	81.4	-4.7	-4.7	-9.0
Age when periods started (menarche)	8.9	21.5	35.3	-3.9	-3.7	-5.9
Wheeze or whistling in the chest in last year	7.6	13.5	17.8	3.7	3.0	4.2
Alcohol intake versus 10 years previously	7.4	11.1	18.5	3.0	2.5	4.3
Body fat percentage	7.1	27.9	60.8	3.0	3.7	7.8
Comparative height size at age 10	7.1	39.0	57.0	7.0	3.2	7.5
Diabetes (father)	7.0	8.6	14.0	3.1	1.4	3.7
Bipolar Disorder or Schizophrenia	6.8	16.5	39.5	0.0	-3.2	-6.3
Comparative body size at age 10	6.6	18.3	26.7	1.9	4.9	5.2
Nervous feelings	6.5	12.2	18.6	-4.3	0.1	-4.2
Trunk fat percentage	6.4	25.8	56.4	3.0	3.5	7.5
Leg fat percentage (left)	6.2	22.6	51.7	2.2	3.4	7.2
Alcohol intake frequency.	6.0	14.0	21.5	4.2	1.5	4.6
Asthma (self-reported)	5.7	11.4	17.8	2.9	4.2	2.8
Tense / ‘highly strung’	5.2	8.6	19.6	-2.3	-0.9	-4.4
Worry (Nagel 2018)	4.9	10.3	15.5	-3.9	0.8	-3.8
Leg fat percentage (right)	4.9	17.6	40.9	1.8	3.0	6.4
Asthma	4.8	9.5	13.7	2.9	3.7	2.6
Bipolar Disorder (2018)	4.7	7.4	16.1	0.0	-2.5	-4.0
Qualifications: NVQ or HND or HNC or equivalent	4.7	5.7	14.3	0.8	1.4	3.8
Schizophrenia (2014)	4.6	10.2	27.2	0.0	-1.9	-5.2
Eye problems/disorders: Cataract	4.5	5.2	6.4	-2.0	-2.5	-2.3
Medication: Ibuprofen (e.g. Nurofen)	4.4	5.5	11.2	1.0	2.1	3.4
Medication: Ventolin 100micrograms inhaler	4.4	5.6	13.3	0.7	3.6	1.8
Schizophrenia (2018)	4.1	8.5	23.3	0.0	-1.5	-4.8
Respiratory disease	3.9	8.8	15.2	2.6	3.9	2.1
Worrier / anxious feelings	3.8	7.2	12.7	-3.6	1.5	-2.6
Time employed in main current job	3.6	4.1	6.0	-2.1	-1.4	-2.4
Number of children fathered	3.6	4.1	6.7	1.5	1.9	2.6
Basal cell carcinoma (self-reported)	3.6	4.3	10.7	0.2	-3.3	-1.5
Blood Eosinophil Count	3.5	27.0	40.6	-6.1	-1.9	-6.4
Seen a psychiatrist for nerves, anxiety, tension or depression	3.4	4.4	7.3	-2.0	-1.4	-2.7
Standing height	3.3	32.4	58.1	7.6	0.8	6.2
Neck or shoulder pain in last month	3.3	4.7	7.0	1.5	2.2	2.6
Medication: Bendroflumethiazide	3.3	5.0	8.4	2.0	1.6	2.9
Fed-up feelings	3.2	5.8	12.0	0.9	2.1	3.5
Pulse rate	3.2	5.3	9.9	-1.6	-3.1	-1.9
Hand grip strength (left)	3.1	8.1	14.1	3.8	0.7	3.1
Heel T-Score	3.0	24.1	46.6	-2.8	-4.2	-6.8
Ever had hysterectomy (womb removed)	3.0	3.4	4.0	-2.0	-1.8	-1.8
Suffer from ‘nerves’	3.0	4.7	7.0	-2.6	-0.7	-2.6
Knee pain experienced in last month	3.0	4.7	13.0	-0.8	3.6	0.7
Forced expiratory volume in 1-second (FEV1), predicted	3.0	6.3	12.3	3.5	0.0	2.6
Primary Biliary Cirrhosis	2.8	4.0	7.0	0.2	2.6	2.2
Height	2.8	54.5	92.2	9.6	0.5	8.4
Risk taking	2.8	4.2	9.8	3.1	1.0	1.3
Hand grip strength (right)	2.7	7.3	15.2	3.9	-0.4	2.5
Hair/balding pattern: Pattern 3	2.7	4.1	5.6	-1.7	-2.4	-1.9
Mouth/teeth dental problems: Dentures	2.7	4.6	12.6	0.2	1.0	3.5
Supplements: Vitamin C	2.7	3.2	3.6	1.7	-1.9	-1.7
Chronotype (morning person)	2.6	5.9	8.4	1.4	2.9	2.8
Average weekly fortified wine intake	2.6	3.1	5.7	-1.3	-1.4	-2.4
Forced vital capacity (FVC)	2.6	9.8	22.6	4.8	1.3	2.3
Illnesses of father: None of the above (group 1)	2.6	3.2	5.3	-2.0	-0.7	-2.3
High cholesterol (Self-reported)	2.6	4.6	9.8	-3.1	-1.4	-1.5
Alzheimer’s Disease (including proxy)	2.5	3.6	10.0	-0.9	-0.0	-3.2
Family relationship satisfaction	2.5	3.0	6.3	2.5	-1.4	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.5	2.9	4.9	1.2	2.2	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.5	5.2	13.7	-0.5	-1.3	-3.7
Ulcerative Colitis (UC)	2.4	4.5	11.2	-0.0	3.3	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	2.3	3.5	4.8	-2.2	-1.2	-2.1
Forced vital capacity (FVC), Best measure	2.3	8.4	22.8	4.8	1.0	1.2
Medication for pain relief, constipation, heartburn	2.2	3.7	6.6	0.2	-2.1	-2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.2	2.6	7.3	-2.7	-0.7	0.2
Ever taken oral contraceptive pill	2.2	2.5	5.2	2.3	0.5	1.4
Eye problems/disorders: Glaucoma	2.2	2.6	4.2	1.7	0.8	2.1
Ulcerative Colitis	2.1	3.0	5.9	0.0	2.4	1.8
Other serious medical condition/disability diagnosed by doctor	2.1	2.7	3.9	-1.3	-1.5	-2.0
Relative age voice broke	2.1	3.1	3.3	-1.7	-1.8	-1.8
Ever unenthusiastic/disinterested for a whole week	2.1	2.5	5.1	-1.5	-0.6	-2.3
Pain all over the body in last month	2.1	2.2	3.7	1.9	0.8	1.5
Loneliness, isolation	2.1	2.9	4.2	1.3	1.6	2.1
Depressed Affect (Nagel 2018)	2.0	4.2	6.4	-0.3	2.5	2.5
Angina	2.0	2.7	7.0	2.6	-0.1	1.0
Medication: Simvastatin	2.0	2.9	6.2	-2.5	-1.3	-0.8
Mouth/teeth dental problems: Loose teeth	2.0	2.4	3.7	1.9	1.7	0.9
Leg pain on walking	2.0	2.5	4.3	1.2	1.3	2.1
Illnesses of father: High blood pressure	2.0	2.4	4.4	1.7	-0.1	2.1
Chronic bronchitis/emphysema (father)	1.9	2.2	4.4	-0.5	2.1	1.4
Mouth/teeth dental problems	1.9	2.9	7.2	-0.4	-1.2	-2.7
Medication: Cholesterol lowering	1.9	3.0	4.5	-2.1	-2.0	-0.5
Glaucoma (self-reported)	1.9	2.2	3.7	1.9	0.5	1.6
Mean time to correctly identify matches	1.9	3.7	7.5	-2.7	0.1	-1.9
Average weekly beer plus cider intake	1.9	2.7	7.9	-2.8	-0.3	0.5
Relative age of first facial hair	1.8	3.7	5.7	-2.0	-1.2	-2.4
Maternal smoking around birth	1.8	2.5	5.5	-0.6	1.4	2.3
Alcohol usually taken with meals	1.8	2.9	5.2	2.3	1.6	0.8
Shortness of breath walking on level ground	1.8	2.2	6.0	0.1	2.4	0.8
Emphysema/chronic bronchitis	1.8	2.1	3.3	-1.3	1.8	1.1
Angina (self-reported)	1.8	2.4	6.5	2.5	-0.5	0.7
Medication: Seretide 50 evohaler	1.8	2.0	2.2	1.4	1.5	1.3
Chest pain or discomfort	1.8	2.5	5.7	2.4	-1.4	0.1
Alzheimer’s Disease (in mother)	1.7	1.9	5.1	-0.4	-0.8	-2.3
Prostate Cancer	1.7	2.4	3.8	-1.2	-1.3	-2.0
Lung FEV1/FVC ratio	1.7	8.4	12.5	-2.0	-2.9	-3.5
Diabetes (mother)	1.7	2.1	2.6	1.5	1.2	1.6
Qualifications: CSEs or equivalent	1.7	2.2	3.0	1.7	-0.9	1.7
Forced expiratory volume in 1-second (FEV1)	1.7	5.7	14.8	3.8	0.9	1.1
Happiness	1.7	2.1	3.8	0.9	-1.3	-1.9
Taking other prescription medications	1.6	2.4	3.1	-1.2	1.6	1.8
Supplements: Glucosamine	1.6	2.1	4.2	1.2	0.8	2.1
Qualifications: None of the above	1.6	3.4	5.4	-2.3	1.6	1.5
Financial difficulties in last 2 years	1.6	2.2	5.0	2.2	0.1	1.2
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	2.8	1.7	-0.5	1.6
Medication: Ibuprofen	1.6	2.0	4.9	0.7	0.8	2.2
Medication: Aspirin	1.6	2.1	5.2	-0.9	-2.3	-0.7
Guilty feelings	1.6	2.4	4.7	0.9	2.2	1.3
Medication: Atorvastatin	1.6	1.9	4.0	-1.2	-2.0	-0.7
Neuroticism	1.5	3.5	7.1	-1.9	2.7	-0.0
Number of live births	1.5	2.1	3.7	-1.9	-0.7	-1.5
Long-standing illness, disability or infirmity	1.5	2.3	3.2	1.2	1.8	1.5
Sitting height	1.4	9.8	21.1	4.6	-1.6	2.4
Pulse wave reflection index	1.4	1.7	4.0	0.9	2.0	0.6
Illnesses of siblings: Diabetes	1.4	1.7	2.4	-1.5	-0.8	1.5
Medication: Aspirin	1.4	1.8	4.9	-0.1	-2.2	-0.6
Commuting to job workplace: Cycle	1.4	1.7	3.9	0.0	-1.1	-2.0
Heart attack/myocardial infarction (self-reported)	1.4	1.8	4.6	0.8	-2.1	-0.2
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	2.3	-1.5	-0.9	-1.5
Mean Putamen Volume	1.3	1.5	3.5	0.4	0.9	1.9
Sensitivity / hurt feelings	1.3	2.3	6.4	-2.5	0.1	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.0	11.8	3.4	0.1	-0.4
Gout (self-reported)	1.3	1.7	3.0	0.1	1.5	1.7
Neuroticism (Nagel 2018)	1.2	2.8	5.0	-1.8	2.2	-0.3
Type 2 Diabetes (T2D) (2018)	1.2	2.3	4.4	1.5	-0.6	2.1
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	1.7	1.2	-1.3	-0.8
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	3.4	-1.4	0.1	-1.9
Heart attack	1.2	1.5	4.0	0.8	-2.0	-0.0
Qualifications: College or University degree	1.2	3.9	9.5	0.3	-1.5	-3.1
Migraine (self-reported)	1.2	1.5	3.5	-1.9	0.5	-0.8
Mineral and other dietary supplements	1.2	1.6	3.4	-1.8	0.3	-1.1
Medication: Gliclazide	1.2	1.3	1.5	1.2	-1.2	1.0
Medication: Blood pressure	1.2	2.3	3.8	0.9	1.9	1.6
Supplements: Fish oil (including cod liver oil)	1.2	1.5	3.7	1.9	0.4	0.9
Pain experienced in last month	1.2	2.0	5.3	0.8	-2.3	0.4
Alzheimer’s Disease (in father)	1.1	1.2	3.5	0.4	-0.0	-1.9
Medication: Metformin	1.1	1.6	4.2	0.3	-0.7	2.1
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.4	5.7	-0.9	-0.9	-2.4
Falls in the last year	1.1	1.5	2.6	1.3	-1.6	0.4
Length of working week for main job	1.1	1.2	2.6	1.6	0.7	0.7
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	4.7	1.0	2.2	-0.3
Exposure to tobacco smoke outside home	1.1	1.4	2.2	0.9	-1.5	-1.1
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	1.9	-1.1	1.4	-0.9
Average weekly red wine intake	1.1	1.6	2.5	-1.2	-1.6	-0.9
Friendships satisfaction	1.1	1.4	2.3	1.5	0.2	-1.3
Rheumatoid Arthritis	1.0	1.4	2.2	0.0	1.5	1.4
Average weekly spirits intake	1.0	1.2	1.9	-1.3	-1.4	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	2.3	0.6	1.2	1.5
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.0	-1.7	0.5	-0.7
Neuroticism score	1.0	2.2	3.6	-1.7	1.9	0.1
Birth weight of first child	1.0	1.9	4.6	-0.1	1.0	2.1
Peak expiratory flow (PEF)	1.0	2.2	6.2	2.5	-0.5	-0.6
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.0	1.7	-0.0	0.9
Blood clot in the leg (DVT)	1.0	1.3	1.9	-1.4	-0.5	-1.3
Mood swings	1.0	1.8	3.1	-1.4	1.8	0.6
Schizophrenia vs Biploar Disorder	0.9	1.2	3.5	0.0	1.9	-0.1
Lupus	0.9	1.3	2.5	-1.6	0.7	1.0
Number of treatments/medications taken	0.9	1.5	3.5	-1.0	0.2	1.9
Supplements: Zinc	0.9	1.0	2.8	1.7	-0.3	0.3
Serious illness, injury or assault to yourself	0.9	1.0	1.7	1.3	-0.8	0.9
Multivitamins +/- minerals	0.9	1.1	2.1	1.0	-0.4	1.4
High blood pressure (mother)	0.9	1.2	2.4	1.0	-0.4	1.6
Fluid intelligence score	0.9	2.0	3.6	1.9	1.5	0.5
Illnesses of mother	0.9	1.1	2.3	-1.5	-0.4	-1.0
Exposure to tobacco smoke at home	0.9	1.0	1.3	1.0	0.8	1.2
Chronic bronchitis/emphysema (mother)	0.9	1.0	1.4	-1.2	1.1	0.7
Had major operations	0.9	1.0	2.6	0.0	-1.6	-0.7
Age at last live birth	0.9	1.2	1.6	-1.3	-0.8	-1.2
Reaction Time	0.8	1.5	2.8	-1.7	0.8	-1.0
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.6	-0.4	1.6	0.8
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.3	-0.5	-0.7	-1.5
Hearing difficulty/problems with background noise	0.8	1.4	2.7	-0.4	-1.1	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.7	4.6	-0.1	-0.7	-2.2
Depression (self-reported)	0.8	0.9	1.6	-1.3	1.1	0.2
Medication: Blood pressure	0.8	1.3	3.2	0.3	-0.8	1.8
Pulse rate, automated reading	0.8	2.5	4.7	-0.6	-2.2	-1.6
Diabetes diagnosed by doctor	0.8	1.3	3.0	0.7	-0.5	1.7
Miserableness	0.8	1.4	3.9	-0.1	0.7	2.0
Alcohol drinker status: Never	0.8	0.9	1.6	1.3	-0.9	0.7
Vascular/heart problems diagnosed by doctor	0.8	2.2	5.1	-1.2	0.2	-2.3
Cholesterol lowering medication	0.8	1.1	1.6	-1.3	-1.1	-0.8
Major Depression (MDD)	0.7	0.9	2.7	0.0	0.2	-1.6
Verbal and Numeric Reasoning (VNR)	0.7	1.8	4.4	0.9	2.1	0.4
Neuroticism (2016)	0.7	1.1	2.3	-1.5	0.8	-0.5
High blood pressure	0.7	1.9	5.3	0.6	0.2	2.3
Medication: Paracetamol	0.7	1.1	2.2	0.0	1.0	1.5
Birth weight	0.7	1.6	3.4	1.0	0.7	1.9
Number of full brothers	0.7	0.9	1.3	1.1	-1.1	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.2	-0.5	-1.1	-1.0
Heart disease (mother)	0.7	0.8	1.3	1.1	0.9	0.7
Smoking status: Previous	0.7	1.0	1.6	0.1	1.2	1.3
Average weekly champagne plus white wine intake	0.7	0.9	2.7	-0.0	-0.1	-1.6
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.9	-0.3	-0.7	-1.4
Commuting to job workplace: Public transport	0.7	0.8	1.2	1.1	-1.0	-0.3
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.7	0.5	-1.3	-0.7
Fractured/broken bones in last 5 years	0.7	0.9	1.8	0.7	0.6	1.4
Ever depressed for a whole week	0.7	0.9	1.7	-0.6	-0.8	-1.3
Myopia	0.7	0.9	2.3	-1.5	-0.7	-0.2
Supplements: Calcium	0.7	0.8	2.0	0.1	-0.7	-1.4
Intelligence (Savage-Jansen 2018)	0.6	1.9	3.6	1.2	1.9	0.9
Irritable Bowel Disease (IBD)	0.6	1.4	4.3	-0.1	2.1	0.1
Blood White Count	0.6	4.3	7.3	-1.3	-2.7	-2.0
Systolic blood pressure, automated reading	0.6	1.8	5.3	-0.4	-0.2	2.3
Vitamin and mineral supplements	0.6	0.9	1.5	-0.9	1.2	-0.5
Diabetes (self-reported)	0.6	1.0	2.6	0.5	-0.2	1.6
Prospective memory result	0.6	0.8	2.0	-1.4	-0.5	-0.4
Breastfed as a baby	0.6	0.7	1.9	1.4	0.5	-0.3
Loud music exposure frequency	0.6	0.7	1.1	-1.1	0.9	0.2
Medication: Omeprazole	0.6	0.8	1.7	-0.4	1.3	0.7
Number of full sisters	0.6	0.7	1.4	-0.3	0.7	1.2
Back pain experienced in last month	0.6	0.9	1.2	-0.8	1.1	0.8
Hearing aid user	0.6	0.7	1.7	-0.7	0.1	1.3
Financial situation satisfaction	0.6	0.8	1.7	0.1	0.8	1.3
Age started oral contraceptive pill	0.6	0.7	2.1	-0.2	1.4	-0.3
Diastolic blood pressure, automated reading	0.6	1.7	3.4	0.7	-1.2	1.8
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	1.5	-1.2	0.9	0.2
HbA1C	0.5	0.5	1.0	-0.1	-0.8	1.0
Hypothyroidism (self reported)	0.5	1.1	2.1	0.4	-1.5	-1.0
Past tobacco smoking	0.5	1.0	2.0	-0.1	-0.9	-1.4
Father’s age at death	0.5	0.7	1.1	-0.9	1.1	0.4
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.8	-0.7	-0.1	-1.7
Headache pain in last month	0.5	0.8	1.2	-0.9	1.1	-0.5
Medication: Amlodipine	0.5	0.7	2.0	0.0	-1.4	-0.2
Medication: Allopurinol	0.5	0.7	1.2	0.1	1.1	0.9
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.4	0.5	1.2	0.1
Hypertension (Self-reported)	0.5	1.3	3.6	0.4	-0.0	1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.3	1.1	0.2	-0.5
Qualifications: nursing, teaching	0.5	0.8	1.9	0.5	-0.6	-1.4
Breast cancer (self-reported)	0.5	0.6	1.4	0.4	0.5	1.2
Smoking status: Current	0.5	0.7	1.2	0.7	-1.1	0.7
Mother’s age at death	0.5	0.7	1.2	0.1	-0.9	-1.1
Alcohol drinker status: Previous	0.5	0.6	1.5	0.4	-0.3	1.2
Ovarian Cancer	0.4	0.5	0.8	-0.9	0.8	-0.3
Crohns Disease (2012)	0.4	0.7	1.7	0.0	0.6	-1.3
LDL Cholesterol	0.4	0.7	2.0	0.0	-0.3	-1.4
Blood Platelet Count	0.4	4.7	12.7	-3.6	-0.4	-1.1
Systolic Blood Pressure	0.4	2.1	3.4	1.3	-1.9	1.2
Allergy or Eczema	0.4	1.0	1.9	-1.0	-0.3	-1.4
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.2	0.0	0.5	1.1
Current tobacco smoking	0.4	0.7	0.8	0.7	-0.8	0.9
Stomach or abdominal pain in last month	0.4	0.5	0.7	-0.8	-0.4	-0.8
Lung cancer (father)	0.4	0.5	0.7	0.4	0.9	0.7
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.6	0.6	-0.3	-1.3
Number of operations (self-reported)	0.4	0.6	1.5	-0.1	0.6	1.2
Irritability	0.4	0.6	1.6	0.3	1.2	0.5
Pack years of smoking	0.4	0.5	0.9	-0.9	-0.6	0.6
Depression (Nagel 2018)	0.3	0.4	1.2	-0.1	1.1	-0.1
Crohns Disease (2017)	0.3	0.6	1.8	0.3	-0.0	-1.3
Age at First Birth	0.3	0.4	0.6	0.8	0.5	-0.5
Waist Hip Ratio (WHR)	0.3	1.5	3.1	0.9	0.6	1.8
Cardiovascular Disease	0.3	0.9	2.4	-0.3	0.4	1.5
Lung FVC	0.3	1.6	4.2	0.5	0.5	-2.1
Medication: Co-codamol	0.3	0.3	0.6	0.4	-0.8	0.3
Allergy	0.3	0.8	1.9	-0.7	-1.4	-0.2
Medication: Ramipril	0.3	0.3	0.6	0.2	-0.8	0.6
Medication: Lansoprazole	0.3	0.4	0.6	-0.7	0.8	0.2
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.8	0.9	-0.7	0.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	0.9	-0.3	-1.0	-0.8
High blood pressure (siblings)	0.3	0.4	0.8	0.9	-0.5	-0.5
Ever had bowel cancer screening	0.3	0.3	0.4	-0.5	0.6	-0.6
Commuting to job workplace: Walk	0.3	0.3	0.4	-0.6	-0.4	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.7	0.2	0.8	0.4
Osteoporosis (self-reported)	0.3	0.3	0.9	-0.9	-0.1	0.1
Heart disease (siblings)	0.3	0.3	0.8	-0.2	-0.4	0.9
Fasting Glucose	0.2	0.2	0.4	-0.3	0.4	-0.6
Triglycerides	0.2	0.3	0.8	0.0	-0.3	0.9
Smoking Status	0.2	0.5	1.3	0.3	0.1	1.2
Medication for hormone replacement therapy	0.2	0.2	0.4	-0.3	0.0	-0.6
Pack years adult smoking proportion	0.2	0.3	0.6	-0.1	-0.6	0.8
Townsend deprivation index at recruitment	0.2	0.3	0.6	-0.2	-0.5	0.8
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.6	-0.4	0.3	0.8
Medication: Levothyroxine sodium	0.2	0.3	0.7	-0.8	0.2	0.3
Hair/balding pattern: Pattern 2	0.2	0.2	0.5	-0.2	-0.2	-0.7
Had menopause	0.2	0.3	0.7	-0.8	-0.0	-0.3
Had other major operations	0.2	0.2	0.5	0.4	-0.1	0.7
Illnesses of siblings	0.2	0.3	0.5	0.4	0.7	-0.4
Noisy workplace	0.2	0.3	0.4	0.2	0.7	0.6
Worry too long after embarrassment	0.2	0.3	0.6	-0.2	0.5	-0.7
Age at first live birth	0.2	0.4	0.8	-0.0	-0.9	-0.6
Health satisfaction	0.2	0.3	0.8	0.9	-0.1	-0.4
Overall health rating	0.2	0.4	1.0	0.1	-0.2	1.0
Illnesses of father: Heart disease	0.2	0.3	0.5	-0.1	-0.7	0.7
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.6	-0.7	0.7	0.4
Wears glasses or contact lenses	0.2	0.3	0.7	-0.0	0.3	0.8
Medication: Lisinopril	0.2	0.3	0.5	0.2	-0.6	0.7
Breast Cancer	0.1	0.2	0.2	-0.4	0.4	0.5
Body Mass Index (BMI) (2010)	0.1	0.2	0.5	0.0	0.7	0.0
Tanning	0.1	1.7	3.3	0.1	-1.4	-1.8
Hearing difficulty/problems: Yes	0.1	0.1	0.2	-0.2	-0.4	-0.5
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	0.2	0.5	0.1
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.6	-0.1	0.8	0.0
Medication: Atenolol	0.1	0.2	0.3	0.6	0.1	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.3	-0.5	-0.0	-0.1
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	-0.2	0.1	0.5
Hair/balding pattern: Pattern 4	0.1	0.3	0.5	0.5	0.7	0.3
Pulse wave peak to peak time	0.1	0.2	0.4	0.7	-0.2	-0.1
Eye problems/disorders: None of the above	0.1	0.1	0.3	-0.4	0.5	0.0
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.1	0.2	0.4
Medication for cholesterol	0.1	0.2	0.6	0.2	-0.8	-0.1
Osteoarthritis (self-reported)	0.1	0.1	0.3	-0.2	0.6	0.1
Number of self-reported non-cancer illnesses	0.1	0.2	0.6	-0.8	-0.4	-0.1
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.4	0.2	-0.6	-0.1
Ever smoked	0.1	0.1	0.3	0.6	0.0	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.0	0.1	0.0	0.2	-0.2
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	1.3	2.3	-1.5	1.2	-0.3
Severe depression (siblings)	0.0	0.0	0.1	0.2	-0.0	0.1
Medication: Paracetamol	0.0	0.0	0.1	-0.1	-0.3	0.2
Unable to work because of sickness or disability	0.0	0.1	0.1	-0.3	-0.0	-0.2

Hub : Genes

KCTD13

Models

Trait associations