TWAS hub - TAOK2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Sun Exposed Lower leg	0.105	0.0420	0.00440	0.001	NA	0.006	NA	0.004	0.2500	NA	0.0900	NA	0.13000
2	ROSMAP	Brain Pre-frontal Cortex	0.042	0.0186	0.00042	0.020	0.027	0.020	0.026	0.021	0.0011	0.00017	0.0011	0.00024	0.00082

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Arm fat-free mass (left)	17.8	90.5	174.2	-2.6	-13.2
Arm predicted mass (left)	17.5	89.1	171.6	-2.6	-13.1
Basal metabolic rate	17.3	95.9	187.7	-2.0	-13.7
Whole body water mass	16.7	95.0	185.0	-2.3	-13.6
Waist circumference	16.6	60.8	118.8	-1.7	-10.9
Arm fat-free mass (right)	16.2	83.1	161.3	-2.2	-12.7
Whole body fat-free mass	16.2	92.4	179.6	-2.3	-13.4
Weight	16.1	79.2	156.2	-1.5	-12.5
Arm predicted mass (right)	16.1	82.2	158.8	-2.4	-12.6
Leg fat-free mass (right)	16.0	85.6	169.0	-1.5	-13.0
Leg predicted mass (right)	16.0	85.5	169.0	-1.4	-13.0
Leg fat-free mass (left)	15.7	83.0	163.8	-1.5	-12.8
Leg predicted mass (left)	15.7	83.0	163.8	-1.5	-12.8
Trunk predicted mass	15.0	85.7	163.8	-2.7	-12.8
Trunk fat-free mass	14.9	85.5	163.8	-2.7	-12.8
Arm fat mass (left)	13.7	56.2	112.4	-0.4	-10.6
Arm fat mass (right)	13.5	55.4	110.2	-0.8	-10.5
Body mass index (BMI)	12.0	51.0	101.9	-0.3	-10.1
Hip circumference	11.6	50.0	99.2	-0.9	-10.0
Impedance of whole body	11.3	57.5	114.5	0.7	10.7
Leg fat mass (left)	11.1	43.4	86.3	-0.7	-9.3
Whole body fat mass	10.8	44.9	89.3	-0.7	-9.4
Impedance of leg (right)	10.7	52.1	104.0	0.2	10.2
Leg fat mass (right)	10.2	39.7	78.9	-0.7	-8.9
Impedance of arm (left)	9.9	45.9	89.7	1.5	9.5
Impedance of leg (left)	9.8	47.7	95.3	0.3	9.8
Number of incorrect matches in round	9.6	15.9	31.7	0.3	5.6
Trunk fat mass	9.1	39.1	77.8	-0.6	-8.8
Impedance of arm (right)	9.0	41.8	83.4	0.6	9.1
Blood Red Count	8.7	84.1	112.4	-7.5	10.6
BMI	8.2	47.5	93.5	-1.3	-9.7
Bipolar Disorder or Schizophrenia	8.0	19.6	39.1	0.2	6.3
Arm fat percentage (right)	6.8	26.7	53.4	-0.2	-7.3
Arm fat percentage (left)	6.5	25.9	51.8	0.2	-7.2
Alcohol intake versus 10 years previously	6.4	9.6	18.5	-0.8	-4.3
Schizophrenia (2014)	6.2	13.6	27.2	0.3	5.2
Medication: Bendroflumethiazide	5.9	9.0	13.0	-2.2	-3.6
Bipolar Disorder (2018)	5.6	8.9	17.5	-0.5	4.2
Schizophrenia (2018)	5.5	11.4	21.9	0.9	4.7
Pain all over the body in last month	5.4	5.8	9.9	-3.1	-1.4
Alcohol intake frequency.	5.3	12.4	13.9	-3.3	-3.7
Diabetes (father)	5.2	6.4	12.6	0.5	-3.5
Age when periods started (menarche)	5.2	12.4	20.6	2.0	4.5
Qualifications: NVQ or HND or HNC or equivalent	5.0	6.1	12.1	-0.1	-3.5
Nervous feelings	4.9	9.1	14.3	2.0	3.8
Tense / ‘highly strung’	4.5	7.4	12.2	-1.6	3.5
Body fat percentage	4.5	17.6	35.2	-0.1	-5.9
Comparative height size at age 10	4.5	24.6	47.1	-1.5	-6.9
Mouth/teeth dental problems: Dentures	4.2	7.1	12.6	-1.2	-3.6
Blood Eosinophil Count	4.1	31.4	61.6	1.1	7.8
Leg fat percentage (left)	4.1	14.7	29.3	-0.5	-5.4
Trunk fat percentage	4.0	16.0	32.0	0.0	-5.7
Ever smoked	3.9	6.9	13.6	-3.7	-0.4
Average weekly fortified wine intake	3.8	4.4	4.5	2.1	2.1
Alzheimer’s Disease (including proxy)	3.7	5.4	5.7	2.3	2.4
Fed-up feelings	3.7	6.7	13.3	-0.3	-3.6
High blood pressure	3.7	10.2	16.6	-2.0	-4.1
Seen a psychiatrist for nerves, anxiety, tension or depression	3.6	4.7	9.2	-0.4	3.0
Number of children fathered	3.6	4.1	7.9	0.4	-2.8
Medication: Blood pressure	3.5	6.2	8.9	-1.9	-3.0
Allergy or Eczema	3.4	9.0	12.9	3.6	2.2
Commuting to job workplace: Cycle	3.4	4.1	6.6	-2.6	1.3
Vascular/heart problems diagnosed by doctor	3.4	9.3	13.9	2.2	3.7
Height	3.3	63.0	110.2	-4.0	-10.5
Hayfever, allergic rhinitis or eczema	3.3	7.1	12.7	3.6	1.2
Time employed in main current job	3.3	3.8	7.3	-0.5	2.7
Medication: Ventolin 100micrograms inhaler	3.3	4.3	8.1	2.8	-0.7
Body Mass Index (BMI) (2010)	3.1	4.2	8.4	-0.3	-2.9
Ever had hysterectomy (womb removed)	3.1	3.5	4.8	-2.2	1.5
Qualifications: CSEs or equivalent	3.1	4.1	6.0	-1.5	-2.4
Leg fat percentage (right)	3.1	11.3	22.3	-0.5	-4.7
Had major operations	3.1	3.6	7.3	-2.7	-0.1
Hypertension (Self-reported)	3.1	8.5	13.8	-1.8	-3.7
Medication: Lisinopril	3.1	4.1	4.3	-2.1	-1.9
Illnesses of father: High blood pressure	3.1	3.9	5.8	1.4	-2.4
Hand grip strength (left)	3.0	8.0	12.5	-1.9	-3.5
High blood pressure (mother)	3.0	4.1	6.9	-1.2	-2.6
Lupus	2.9	4.4	7.8	2.8	-1.0
Hand grip strength (right)	2.9	8.0	10.9	-2.2	-3.3
Medication: Ibuprofen (e.g. Nurofen)	2.8	3.6	7.0	-0.5	-2.7
Pulse wave Arterial Stiffness index	2.8	3.2	4.7	-2.2	-1.3
Standing height	2.8	28.0	51.4	-2.1	-7.2
Asthma (self-reported)	2.8	5.5	10.4	3.2	-0.7
Hearing difficulty/problems with background noise	2.7	4.3	4.6	-2.1	2.0
Diastolic blood pressure, automated reading	2.6	8.0	9.1	-3.0	-2.6
Allergy	2.5	5.8	10.6	-3.2	-1.1
Wheeze or whistling in the chest in last year	2.5	4.5	7.7	1.1	-2.8
Qualifications: College or University degree	2.5	8.0	10.7	3.3	2.3
Alzheimer’s Disease (in mother)	2.4	2.8	3.5	1.9	1.5
Gout (self-reported)	2.4	3.3	3.5	1.7	-1.9
Medication: Blood pressure	2.4	4.6	4.8	-2.1	-2.2
Worry (Nagel 2018)	2.3	4.9	9.3	0.7	3.1
Systolic blood pressure, automated reading	2.3	6.6	9.1	-2.0	-3.0
Past tobacco smoking	2.3	4.3	5.4	2.3	1.8
Worrier / anxious feelings	2.3	4.4	4.5	2.1	2.1
Medication for cholesterol, blood pressure or diabetes	2.3	3.8	4.0	1.9	2.0
Leg pain on walking	2.3	2.8	4.5	1.1	-2.1
Cardiovascular Disease	2.2	7.1	8.1	-2.9	-2.5
Type 2 Diabetes (T2D) (2018)	2.2	4.1	6.0	-1.5	-2.5
Medication: Metformin	2.2	3.2	5.5	-0.9	-2.3
Supplements: Vitamin C	2.2	2.6	4.3	-1.0	2.1
Illnesses of father: Heart disease	2.2	3.0	5.8	-2.4	-0.5
Alcohol drinker status: Previous	2.2	2.5	2.9	-1.5	-1.7
Heel T-Score	2.1	16.3	32.3	-0.6	5.7
Systolic Blood Pressure	2.1	10.7	14.7	-3.8	-2.6
Mouth/teeth dental problems	2.1	3.3	6.0	0.8	2.4
Asthma	2.1	4.1	7.7	2.8	-0.7
Birth weight	2.1	4.5	6.5	1.6	-2.6
Comparative body size at age 10	2.1	5.9	11.0	0.9	-3.3
Medication: Ibuprofen	2.1	2.5	3.9	-1.0	-2.0
Supplements: Calcium	2.1	2.3	4.4	-0.5	2.1
Major Depression (MDD)	2.0	2.4	4.9	-0.1	2.2
Prostate Cancer	2.0	2.8	3.8	-1.9	1.3
Maternal smoking around birth	2.0	2.9	5.5	0.5	-2.3
Serious illness, injury or assault to yourself	2.0	2.5	3.3	-1.3	-1.8
Pulse wave peak to peak time	2.0	2.3	4.2	2.0	0.7
Health satisfaction	2.0	2.6	4.9	-2.2	0.5
Miserableness	2.0	3.4	6.4	-0.7	-2.5
Depressed Affect (Nagel 2018)	1.9	4.0	8.0	0.3	-2.8
Smoking Status	1.9	4.6	7.2	-2.7	-1.4
Loneliness, isolation	1.9	2.7	2.9	-1.7	-1.6
Respiratory disease	1.8	4.0	7.9	2.8	0.2
Medication: Ramipril	1.8	2.3	2.7	-1.6	-1.4
Birth weight of first child	1.8	3.3	5.7	1.0	-2.4
Family relationship satisfaction	1.8	2.2	4.4	-2.1	-0.1
Alcohol usually taken with meals	1.7	2.7	4.9	2.2	-0.7
Neck or shoulder pain in last month	1.7	2.5	4.4	-0.7	-2.1
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.6	5.4	1.3	-2.3
Commuting to job workplace: Walk	1.7	1.8	2.7	1.6	1.0
Sitting height	1.6	11.4	15.4	-2.7	-3.9
Pulse wave reflection index	1.6	2.0	3.6	-1.9	-0.6
Tinnitus: Yes, now most or all of the time	1.6	1.9	2.9	-1.0	1.7
Irritability	1.6	2.6	4.0	-2.0	-1.1
Myopia	1.6	2.3	4.6	2.1	0.1
Waist Hip Ratio (WHR)	1.5	6.5	8.1	-2.2	-2.8
Chronotype (morning person)	1.5	3.4	4.1	1.6	-2.0
Number of treatments/medications taken	1.5	2.7	3.1	-1.5	-1.8
Diabetes (mother)	1.5	1.9	3.7	-0.3	-1.9
Mean time to correctly identify matches	1.5	2.9	5.4	0.5	2.3
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	3.1	-1.8	0.3
Eye problems/disorders: Cataract	1.5	1.8	3.2	0.6	1.8
Medication for cholesterol	1.5	2.2	4.1	2.0	0.6
Smoking status: Current	1.5	2.4	3.7	-1.9	-1.1
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	3.2	0.4	1.8
Diabetes (self-reported)	1.4	2.1	3.4	-0.9	-1.8
Illnesses of siblings	1.4	1.9	3.6	1.9	0.5
Prospective memory result	1.4	1.7	2.8	-1.7	0.8
Glaucoma (self-reported)	1.4	1.7	2.5	0.9	-1.6
Suffer from ‘nerves’	1.4	2.2	3.9	-0.6	2.0
Guilty feelings	1.4	2.2	3.1	-1.7	-1.1
Lung FEV1/FVC ratio	1.3	6.7	12.1	-3.5	1.1
Angina	1.3	1.7	2.3	-1.5	-1.1
Medication: Co-codamol	1.3	1.6	2.8	-1.7	-0.6
Current tobacco smoking	1.3	2.1	2.6	-1.6	-1.2
Taking other prescription medications	1.3	2.1	2.6	1.6	-1.2
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.0	3.6	-1.9	-0.7
Medication for pain relief, constipation, heartburn	1.3	2.2	4.3	-0.1	2.1
Migraine (self-reported)	1.3	1.6	2.4	1.5	0.9
Diabetes diagnosed by doctor	1.3	2.1	4.0	-0.6	-2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	5.4	0.1	2.3
Ever taken oral contraceptive pill	1.3	1.5	1.9	-1.0	-1.4
Reaction Time	1.2	2.4	2.5	1.5	1.6
Crohns Disease (2012)	1.2	2.0	4.0	-0.1	2.0
Blood Platelet Count	1.2	14.0	26.4	5.1	1.2
Forced vital capacity (FVC)	1.2	4.6	9.0	-0.5	-3.0
Qualifications: A levels/AS levels or equivalent	1.2	2.7	3.0	1.7	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	2.9	-0.9	1.7
Number of full brothers	1.2	1.5	1.9	-1.4	-1.0
Illnesses of father: None of the above (group 1)	1.2	1.5	2.9	-0.1	1.7
Ovarian Cancer	1.1	1.4	2.3	1.5	0.7
Triglycerides	1.1	1.8	2.4	-1.1	-1.5
Number of live births	1.1	1.5	3.0	0.1	1.7
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	2.0	1.4	-0.8
Angina (self-reported)	1.1	1.4	2.2	-1.5	-0.8
Illnesses of siblings: Diabetes	1.1	1.3	2.6	-0.2	-1.6
Osteoarthritis (self-reported)	1.1	1.4	2.9	1.7	0.1
Medication: Aspirin	1.1	1.4	2.9	-1.7	-0.0
Eye problems/disorders: Glaucoma	1.1	1.3	2.6	0.1	-1.6
Heart disease (siblings)	1.1	1.3	1.3	-1.2	-1.1
Mean Putamen Volume	1.0	1.2	2.0	-0.6	-1.4
HDL Cholesterol	1.0	1.6	2.4	1.6	0.9
Relative age of first facial hair	1.0	2.1	4.2	-0.1	2.0
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	3.9	-0.7	2.0
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	1.6	-0.9	1.2
Loud music exposure frequency	1.0	1.1	2.2	1.5	0.0
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	1.4	1.0	1.2
Medication: Gliclazide	1.0	1.2	1.7	-0.8	-1.3
Average weekly champagne plus white wine intake	1.0	1.4	2.7	0.1	1.7
Number of operations (self-reported)	1.0	1.4	1.9	-1.4	-1.0
Intelligence (Savage-Jansen 2018)	0.9	2.6	3.5	1.9	-1.3
LDL Cholesterol	0.9	1.4	2.8	0.2	1.7
Ulcerative Colitis	0.9	1.3	1.9	1.4	-0.9
Supplements: Glucosamine	0.9	1.2	1.5	0.9	-1.2
Qualifications: None of the above	0.9	1.8	2.1	-1.4	-1.3
Medication: Amlodipine	0.9	1.2	1.5	-1.2	-1.0
High blood pressure (siblings)	0.9	1.3	2.6	-1.6	0.1
Exposure to tobacco smoke outside home	0.9	1.3	1.9	-1.4	0.8
Medication: Aspirin	0.9	1.2	2.4	-1.5	-0.2
Smoking status: Previous	0.9	1.3	1.7	-1.0	-1.3
Back pain experienced in last month	0.9	1.3	2.0	0.7	-1.4
Breast cancer (self-reported)	0.9	1.0	1.4	1.2	-0.8
Mother’s age at death	0.9	1.1	1.6	-1.3	0.8
Alzheimer’s Disease (in father)	0.8	0.9	1.7	0.1	1.3
Crohns Disease (2017)	0.8	1.7	3.1	-0.5	1.8
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	1.8	-0.4	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	1.3	-1.0	-1.1
Multivitamins +/- minerals	0.8	1.0	1.3	-1.1	-0.8
Hair/balding pattern: Pattern 3	0.8	1.2	2.0	-0.7	1.4
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	4.8	-1.0	-2.2
Illnesses of mother	0.8	0.9	1.8	0.1	1.4
Ever highly irritable/argumentative for 2 days	0.8	1.0	1.8	-0.4	-1.4
Emphysema/chronic bronchitis	0.8	1.0	1.3	0.7	-1.2
Medication: Allopurinol	0.8	1.0	1.1	1.0	-1.0
Average weekly beer plus cider intake	0.8	1.2	1.4	-1.0	-1.2
Age started oral contraceptive pill	0.8	1.1	1.1	1.0	1.1
Hair/balding pattern: Pattern 2	0.7	0.9	1.0	1.0	0.9
Fluid intelligence score	0.7	1.4	2.2	1.5	-0.8
Medication: Cholesterol lowering	0.7	1.1	2.0	-1.4	-0.3
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	1.5	0.9	1.2
Qualifications: nursing, teaching	0.7	1.2	1.3	1.2	1.0
Unable to work because of sickness or disability	0.7	0.9	1.4	-1.2	0.6
Medication for hormone replacement therapy	0.6	0.7	1.0	-0.6	1.0
Townsend deprivation index at recruitment	0.6	0.9	1.6	-0.5	-1.3
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.1	0.4	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	2.6	-0.2	1.6
Financial situation satisfaction	0.6	0.7	1.1	-0.5	-1.1
High cholesterol (Self-reported)	0.6	1.0	2.0	-0.1	1.4
Verbal and Numeric Reasoning (VNR)	0.5	1.2	1.8	1.4	-0.7
Primary Biliary Cirrhosis	0.5	0.7	1.4	-0.3	-1.2
Hearing difficulty/problems: Yes	0.5	0.8	0.8	-0.8	0.9
Relative age voice broke	0.5	0.8	1.3	-0.4	1.2
Chronic bronchitis/emphysema (father)	0.5	0.6	0.9	0.9	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	0.9	-0.8	1.0
Medication: Simvastatin	0.5	0.8	1.6	-1.3	0.1
Pulse rate	0.5	0.8	1.7	-0.1	1.3
Happiness	0.5	0.6	1.2	-0.2	1.1
Medication: Paracetamol	0.5	0.8	1.5	0.2	-1.2
Forced vital capacity (FVC), Best measure	0.5	1.8	3.5	-0.3	-1.9
Number of full sisters	0.5	0.6	1.0	0.3	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.1	0.4	-1.1
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.1	-1.0	0.1
Schizophrenia vs Biploar Disorder	0.4	0.5	0.8	-0.3	0.9
Neuroticism (2016)	0.4	0.6	0.9	0.7	0.9
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.9	-1.0	-0.3
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.9	-0.9	-0.1
Medication: Levothyroxine sodium	0.4	0.6	1.3	1.1	0.1
Had other major operations	0.4	0.5	0.8	0.3	-0.9
Financial difficulties in last 2 years	0.4	0.6	0.9	-0.9	-0.5
Breastfed as a baby	0.4	0.4	0.7	0.8	0.5
Peak expiratory flow (PEF)	0.4	0.9	1.7	-1.3	0.3
Pulse rate, automated reading	0.4	1.4	2.2	-0.7	1.5
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.0	1.0	0.2
Knee pain experienced in last month	0.4	0.6	1.3	1.1	0.1
Mood swings	0.4	0.8	0.8	0.9	-0.8
Long-standing illness, disability or infirmity	0.4	0.7	1.0	1.0	-0.6
Friendships satisfaction	0.4	0.5	0.7	-0.8	0.5
Osteoporosis (self-reported)	0.4	0.5	0.8	0.9	0.5
Hearing aid user	0.4	0.5	0.7	-0.6	-0.8
Basal cell carcinoma (self-reported)	0.4	0.5	1.0	1.0	0.2
Lung FVC	0.3	1.6	2.5	1.6	0.8
Average weekly spirits intake	0.3	0.4	0.7	-0.1	-0.9
Vitamin and mineral supplements	0.3	0.4	0.7	0.9	-0.0
Severe depression (siblings)	0.3	0.3	0.6	0.8	0.2
Medication: Atenolol	0.3	0.4	0.5	-0.5	-0.7
Had menopause	0.3	0.4	0.4	-0.7	0.6
Heart attack	0.3	0.4	0.6	-0.8	-0.4
Father’s age at death	0.3	0.4	0.5	0.6	-0.7
Lung cancer (father)	0.3	0.3	0.5	0.4	-0.7
Exposure to tobacco smoke at home	0.3	0.3	0.5	0.3	-0.7
Hair/balding pattern: Pattern 4	0.3	0.6	1.2	-1.1	-0.2
Headache pain in last month	0.3	0.6	1.1	-0.2	1.1
Medication: Seretide 50 evohaler	0.3	0.3	0.4	-0.7	-0.5
Overall health rating	0.3	0.7	1.3	-0.3	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.6	0.8	0.4
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.7	0.1	-0.8
Risk taking	0.3	0.5	0.8	-0.9	-0.3
Fractured/broken bones in last 5 years	0.3	0.4	0.9	0.0	-0.9
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.7	-0.8	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.9	-0.0	0.9
Irritable Bowel Disease (IBD)	0.2	0.5	0.9	0.1	1.0
Fasting Glucose	0.2	0.2	0.4	-0.3	0.7
HbA1C	0.2	0.2	0.4	0.6	0.1
Blood White Count	0.2	1.5	2.8	-1.7	-0.4
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.6	-0.2	-0.8
Supplements: Zinc	0.2	0.2	0.3	0.6	0.2
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	-0.1	-0.6
Falls in the last year	0.2	0.2	0.4	-0.7	0.1
Noisy workplace	0.2	0.2	0.4	0.0	-0.7
Depression (self-reported)	0.2	0.2	0.3	-0.5	0.5
Blood clot in the leg (DVT)	0.2	0.2	0.5	0.0	0.7
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.7	0.4	0.9
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.3	0.3	0.5
Medication: Omeprazole	0.2	0.3	0.5	0.7	-0.3
Heart disease (mother)	0.2	0.2	0.4	-0.2	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.6	-0.7	0.1
Chest pain or discomfort	0.2	0.3	0.6	-0.8	-0.3
Age at last live birth	0.2	0.3	0.3	-0.5	0.6
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.4	-0.6	0.2
Medication: Paracetamol	0.2	0.4	0.7	-0.8	-0.3
Ever depressed for a whole week	0.2	0.3	0.5	0.7	0.3
Cholesterol lowering medication	0.2	0.3	0.5	-0.7	0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.4	0.6	-0.0
Depression (Nagel 2018)	0.1	0.1	0.2	-0.1	0.4
Ulcerative Colitis (UC)	0.1	0.2	0.4	0.6	-0.2
Breast Cancer	0.1	0.3	0.5	0.7	0.2
Age at First Birth	0.1	0.1	0.2	0.3	0.4
Rheumatoid Arthritis	0.1	0.2	0.4	-0.0	-0.6
Hypothyroidism (self reported)	0.1	0.3	0.5	0.2	0.7
Tanning	0.1	1.7	1.8	1.3	1.4
Sensitivity / hurt feelings	0.1	0.2	0.4	0.0	0.6
Pack years adult smoking proportion	0.1	0.1	0.3	-0.2	-0.5
Stomach or abdominal pain in last month	0.1	0.2	0.3	-0.2	0.5
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.3	0.6	-0.0
Neuroticism score	0.1	0.3	0.3	-0.5	-0.5
Medication: Lansoprazole	0.1	0.1	0.1	-0.3	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.5	-0.6	-0.7
Length of working week for main job	0.1	0.1	0.2	-0.2	-0.4
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.1	-0.2	0.4
Worry too long after embarrassment	0.1	0.1	0.2	0.2	0.4
Shortness of breath walking on level ground	0.1	0.1	0.1	0.3	0.2
Eye problems/disorders: None of the above	0.1	0.1	0.1	-0.2	-0.3
Average weekly red wine intake	0.1	0.1	0.2	0.2	0.5
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.3	0.6	0.0
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.2	-0.3	-0.4
Wears glasses or contact lenses	0.1	0.2	0.3	0.0	-0.6
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.5	-0.2
Alcohol drinker status: Never	0.1	0.1	0.2	-0.4	-0.3
Neuroticism (Nagel 2018)	0.0	0.1	0.2	0.4	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0
Neuroticism	0.0	0.0	0.0	-0.2	-0.1
Hair Pigment	0.0	0.1	0.2	-0.4	-0.3
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.0	0.2	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.1	-0.1	0.2
Age at first live birth	0.0	0.0	0.0	0.0	-0.2
Ever had bowel cancer screening	0.0	0.0	0.0	0.1	-0.1
Mineral and other dietary supplements	0.0	0.0	0.1	0.2	0.2
Number of self-reported non-cancer illnesses	0.0	0.0	0.0	-0.0	0.2
Medication: Atorvastatin	0.0	0.0	0.1	0.0	-0.3
Pain experienced in last month	0.0	0.1	0.1	0.0	-0.3
Pack years of smoking	0.0	0.0	0.1	-0.3	-0.2

Hub : Genes

TAOK2

Models

Trait associations