TWAS hub - NSUN5P2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0230	0.0130	4.9e-03	-0.002	0.017	0.017	0.015	0.003	6.4e-01	3.2e-03	3.4e-03	4.8e-03	1.2e-01
2	GTEx	Colon Transverse	0.1510	0.0680	8.9e-03	0.127	NA	0.084	NA	0.121	1.3e-06	NA	8.5e-05	NA	2.3e-06
3	GTEx	Esophagus Muscularis	0.1430	0.0590	6.5e-05	0.036	NA	0.074	NA	0.069	2.9e-03	NA	2.9e-05	NA	5.3e-05
4	ROSMAP	Brain Pre-frontal Cortex	0.0638	0.0287	1.2e-07	0.067	0.065	0.060	0.066	0.064	4.9e-09	9.8e-09	3.3e-08	7.8e-09	1.1e-08
5	TCGA	Soft Tissue Sarcoma	0.1160	0.0580	3.0e-03	0.000	0.044	0.048	NA	0.019	3.1e-01	1.3e-03	8.1e-04	NA	2.5e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Triglycerides	7.2	11.8	31.1	-5.6	-1.7	-2.8	-2.9	-3.0
Medication: Seretide 50 evohaler	4.1	4.7	11.5	2.5	-3.4	-2.3	0.8	-0.1
Gout (self-reported)	3.7	5.0	9.8	-3.1	-1.7	-2.1	-2.8	-0.3
Falls in the last year	3.5	4.7	7.3	-2.1	-2.0	-2.2	-2.7	-1.9
Severe depression (siblings)	3.2	3.6	9.0	-0.8	3.0	2.4	1.5	-0.4
Ever unenthusiastic/disinterested for a whole week	3.2	3.9	8.6	-2.1	2.9	2.4	0.0	-0.6
Medication: Allopurinol	3.2	4.3	6.9	-2.2	-2.3	-2.6	-2.1	-0.7
Noisy workplace	3.0	3.7	8.5	1.3	-2.7	-2.9	-0.8	-0.4
Chest pain or discomfort	2.9	4.2	7.1	-0.6	-2.1	-2.7	-2.4	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	2.8	3.8	7.7	0.8	-2.3	-2.3	0.1	-2.8
Birth weight	2.8	6.1	17.8	1.4	-2.1	-2.2	-1.2	-4.2
Impedance of whole body	2.8	14.2	33.6	-3.9	-2.5	-3.8	-5.8	1.3
Type 2 Diabetes (T2D) (2012)	2.6	3.0	8.0	2.8	-0.8	0.3	2.4	0.6
Fluid intelligence score	2.6	5.4	14.1	-0.8	2.6	3.7	2.2	-0.6
Impedance of arm (left)	2.6	11.8	25.6	-3.7	-2.4	-3.7	-5.1	-0.0
Impedance of leg (right)	2.5	12.1	29.4	-3.5	-1.9	-3.5	-5.4	1.7
Impedance of leg (left)	2.5	12.3	32.2	-3.4	-1.7	-3.0	-5.7	2.3
Impedance of arm (right)	2.5	11.5	21.2	-3.7	-2.6	-4.0	-4.6	-0.2
Ever smoked	2.4	4.3	8.6	-0.4	-1.0	-2.6	-2.9	-2.2
Intelligence (Savage-Jansen 2018)	2.0	6.0	16.1	-0.0	3.1	4.0	2.0	-0.5
Respiratory disease	2.0	4.4	7.8	2.8	-1.7	-1.5	1.6	-2.7
Leg pain on walking	2.0	2.5	5.7	-2.3	-0.4	-1.1	-2.4	0.1
Age when periods started (menarche)	1.9	4.5	9.0	2.1	-3.0	-2.8	0.2	-0.9
Medication: Atenolol	1.9	2.4	4.0	-1.6	1.1	0.5	-2.0	2.0
Father’s age at death	1.9	2.5	5.8	1.6	0.2	1.6	2.4	1.2
Neck or shoulder pain in last month	1.9	2.7	5.0	2.0	-1.2	-0.9	1.4	-2.2
Deep venous thrombosis (DVT) (self-reported)	1.9	2.4	4.9	1.8	-1.5	-1.0	0.9	-2.2
LDL Cholesterol	1.8	2.8	6.4	2.4	-0.4	-0.1	2.5	-1.2
Sensitivity / hurt feelings	1.8	3.0	8.4	-1.0	0.2	-0.1	-2.4	2.9
Allergy	1.8	4.2	8.9	-3.0	2.1	1.6	-1.1	2.0
Mineral and other dietary supplements	1.8	2.4	3.8	1.4	-1.7	-1.9	-0.2	-1.9
Supplements: Fish oil (including cod liver oil)	1.8	2.4	4.7	-1.8	1.3	1.6	-0.4	2.2
Lupus	1.7	2.6	5.1	0.2	-1.7	-2.3	-2.0	-1.1
Past tobacco smoking	1.7	3.1	6.4	0.7	0.7	1.9	2.5	2.1
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	5.1	0.2	-1.8	-2.3	-1.5	-1.5
Mouth/teeth dental problems	1.7	2.6	7.1	-0.0	1.7	2.7	1.6	0.5
Ever highly irritable/argumentative for 2 days	1.7	2.0	4.7	-0.3	2.2	1.8	1.0	-1.0
Emphysema/chronic bronchitis	1.7	1.9	2.7	1.6	-1.4	-1.1	1.3	-1.5
Illnesses of siblings: Diabetes	1.7	2.1	5.0	1.3	-1.3	-1.3	0.7	-2.2
Ever depressed for a whole week	1.7	2.1	3.9	-0.5	1.8	2.0	1.6	-0.7
Alzheimer’s Disease (in mother)	1.6	1.9	6.2	-1.3	-0.1	-0.1	-1.2	2.5
Age at First Birth	1.6	2.3	4.7	-0.1	2.2	2.0	1.6	-0.4
Alcohol intake versus 10 years previously	1.6	2.3	4.3	-1.5	-1.4	-2.1	-1.8	-0.1
Blood clot in the leg (DVT)	1.6	2.0	4.9	1.5	-1.3	-0.9	0.7	-2.2
Comparative body size at age 10	1.6	4.4	8.2	-2.6	1.7	2.9	1.9	-0.9
Mother’s age at death	1.6	2.0	4.0	-0.5	1.9	2.0	0.7	1.3
Tinnitus: Yes, now most or all of the time	1.6	1.9	4.4	-0.2	2.1	1.8	0.1	1.3
Verbal and Numeric Reasoning (VNR)	1.5	3.6	8.3	0.4	1.9	2.9	2.3	-0.5
Mean Putamen Volume	1.5	1.8	2.6	1.4	-1.0	-1.3	-1.2	-1.6
Medication for hormone replacement therapy	1.5	1.7	4.2	-1.0	2.1	1.4	0.3	-1.0
Medication: Co-codamol	1.5	1.8	5.0	-0.2	-1.7	-2.2	-0.9	-0.4
Length of working week for main job	1.5	1.6	4.3	0.2	-1.6	-0.9	0.6	-2.1
Qualifications: College or University degree	1.5	4.7	11.4	-1.0	2.9	3.4	1.5	0.5
Risk taking	1.5	2.1	3.6	-0.3	1.7	1.5	1.3	1.9
HDL Cholesterol	1.4	2.3	4.0	1.4	1.4	2.0	1.0	1.5
Ulcerative Colitis	1.4	2.1	5.5	2.4	-0.7	-0.1	1.3	-1.6
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	2.9	1.7	-1.1	-0.3	1.6	-0.8
Prospective memory result	1.4	1.7	3.9	-0.5	-1.2	-2.0	-0.6	-1.6
Tense / ‘highly strung’	1.4	2.3	4.1	-1.5	1.1	0.7	-2.0	1.8
Medication: Blood pressure	1.4	2.6	3.6	-1.2	-1.3	-1.9	-1.7	1.8
Alcohol intake frequency.	1.4	3.3	9.7	-3.1	0.0	-0.4	-2.1	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	3.7	-0.5	1.1	1.4	1.0	-1.9
Illnesses of father: None of the above (group 1)	1.4	1.7	3.4	-1.8	1.3	0.7	-0.8	-1.6
Townsend deprivation index at recruitment	1.3	1.8	3.6	0.1	-1.7	-1.9	-0.8	-1.3
Medication: Ventolin 100micrograms inhaler	1.3	1.7	3.7	1.9	-1.2	-0.7	1.7	-0.5
Eye problems/disorders: None of the above	1.3	1.5	2.9	-1.2	1.7	1.1	-1.3	0.6
Guilty feelings	1.3	1.9	6.4	-1.0	0.2	0.0	-2.5	1.5
Illnesses of father: High blood pressure	1.3	1.6	4.3	0.7	-2.1	-1.7	0.1	0.5
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.3	-0.1	1.5	1.5	1.0	-1.5
Myopia	1.3	1.9	6.5	-2.5	0.7	0.1	-1.5	-0.6
Crohns Disease (2012)	1.2	2.0	4.9	-0.0	-1.8	-2.2	-1.0	0.8
Neuroticism (2016)	1.2	1.8	5.7	-1.7	-0.1	-0.2	-2.4	0.5
Systolic Blood Pressure	1.2	6.1	9.3	0.2	-2.2	-3.0	-3.0	2.7
Smoking Status	1.2	2.9	7.4	0.4	-0.7	-1.9	-1.7	-2.7
Cardiovascular Disease	1.2	3.9	5.8	-1.5	-2.1	-2.4	-1.5	2.1
Neuroticism	1.2	3.0	5.8	-1.4	1.3	0.9	-2.4	2.1
Supplements: Zinc	1.2	1.3	3.3	-0.5	-1.8	-1.5	-0.6	0.6
Qualifications: None of the above	1.2	2.7	6.4	-0.2	-1.3	-1.8	-2.5	1.4
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	4.8	1.0	-1.2	-1.6	0.5	-2.2
Happiness	1.2	1.4	2.5	-0.5	1.5	1.6	1.3	-0.5
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	3.2	0.7	-1.2	-1.8	1.3	-1.0
Commuting to job workplace: Car/motor vehicle	1.2	1.4	3.2	0.2	0.6	1.1	1.4	1.8
Ever taken oral contraceptive pill	1.2	1.3	3.6	1.4	0.1	0.5	1.9	-0.8
Prostate Cancer	1.1	1.5	3.7	0.7	-1.9	-1.9	0.3	0.1
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	3.4	-0.0	-1.3	-0.8	1.2	-1.8
Serious illness, injury or assault to yourself	1.1	1.4	3.0	-0.5	-1.6	-1.7	-0.7	-0.7
Pain all over the body in last month	1.1	1.2	2.8	0.2	-1.1	-1.2	-0.4	1.7
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	2.3	1.3	-1.5	-1.2	0.9	0.3
Illnesses of father: Heart disease	1.1	1.6	3.2	1.7	-0.7	-0.1	1.2	1.8
Ever had bowel cancer screening	1.1	1.2	1.8	-1.0	-1.1	-1.3	-1.4	0.7
Diabetes diagnosed by doctor	1.1	1.8	5.3	0.1	1.5	2.3	1.0	0.8
Unable to work because of sickness or disability	1.1	1.5	3.1	-0.1	-1.2	-1.8	-1.6	-0.4
Alcohol drinker status: Previous	1.1	1.3	3.3	-0.6	-0.4	-0.6	-1.8	1.5
Diabetes (self-reported)	1.0	1.5	4.8	0.4	1.2	2.2	1.1	0.3
Depression (self-reported)	1.0	1.3	5.2	0.1	0.6	0.6	0.6	-2.3
Lung cancer (father)	1.0	1.2	2.8	1.0	-1.7	-1.2	-0.6	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	4.8	-0.8	-0.0	-1.0	-2.2	-0.9
Headache pain in last month	1.0	1.8	5.1	-0.5	-2.3	-1.7	-0.6	-0.3
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	2.8	0.4	1.6	1.7	0.6	-1.6
Had major operations	1.0	1.2	3.5	-0.1	-0.7	-1.3	-1.9	-0.4
Age at last live birth	1.0	1.4	1.9	1.3	1.1	0.9	1.4	-1.2
Family relationship satisfaction	1.0	1.3	2.2	-1.0	1.3	1.5	0.7	-1.0
Smoking status: Previous	1.0	1.4	3.6	-0.9	-0.1	-0.5	-1.6	-1.9
Asthma (self-reported)	1.0	2.0	4.2	2.0	-0.6	-0.1	1.5	-1.9
Medication: Gliclazide	1.0	1.2	2.0	0.9	1.4	1.1	1.1	-0.7
Irritability	1.0	1.7	6.6	-0.9	1.0	-0.0	-2.6	0.5
Neuroticism (Nagel 2018)	0.9	2.2	4.5	-0.9	1.0	0.8	-2.1	2.0
HbA1C	0.9	1.0	2.2	0.8	0.3	0.4	1.5	-1.3
Frequency of depressed mood in last 2 weeks	0.9	1.2	3.1	0.5	-0.8	-1.4	-0.4	-1.8
Average weekly fortified wine intake	0.9	1.1	3.1	-1.8	0.9	0.2	-1.1	-0.2
Supplements: Glucosamine	0.9	1.1	4.9	-0.6	0.3	0.5	-0.0	2.2
Hair/balding pattern: Pattern 2	0.9	1.1	2.9	-1.7	0.9	1.2	-0.3	-0.7
Medication: Ramipril	0.9	1.1	1.7	1.3	-1.2	-0.9	1.1	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	3.5	0.8	-0.7	-0.7	0.5	-1.9
Asthma	0.9	1.7	3.3	1.8	-0.4	0.1	1.4	-1.8
Wheeze or whistling in the chest in last year	0.9	1.6	3.7	1.9	-1.0	-0.5	1.0	-1.5
Hypertension (Self-reported)	0.9	2.4	4.6	-0.5	-2.0	-2.1	-1.4	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.3	0.2	-1.5	-1.1	0.3	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.2	0.8	0.6	1.2	1.5	-0.6
Back pain experienced in last month	0.9	1.4	2.4	-1.5	1.6	0.9	-1.1	-0.4
Average weekly beer plus cider intake	0.9	1.2	2.1	-1.4	1.0	0.2	-1.3	1.1
Alzheimer’s Disease (including proxy)	0.8	1.1	3.7	-1.0	0.6	0.1	-0.7	1.9
Reaction Time	0.8	1.4	4.0	2.0	-0.1	-0.2	1.8	-0.0
Body Mass Index (BMI) (2010)	0.8	1.1	2.4	1.5	-0.3	0.0	1.5	-1.0
Blood White Count	0.8	5.8	13.2	-3.0	-0.8	-2.1	-3.6	1.3
Allergy or Eczema	0.8	2.1	7.2	2.7	-1.1	-1.1	0.7	-0.6
Hand grip strength (left)	0.8	2.2	4.0	2.0	-1.6	-1.4	0.9	-1.4
Number of treatments/medications taken	0.8	1.5	2.9	-1.0	-1.3	-1.7	-0.7	1.2
Diabetes (father)	0.8	0.9	1.6	0.9	0.7	0.8	1.3	1.0
Qualifications: CSEs or equivalent	0.8	1.0	2.0	0.0	-1.4	-1.4	0.6	-0.8
High blood pressure	0.8	2.2	4.6	-0.1	-2.0	-2.1	-1.1	1.2
High blood pressure (mother)	0.8	1.1	2.3	0.2	-1.5	-1.5	-1.0	-0.4
Number of incorrect matches in round	0.8	1.4	4.5	0.6	-2.1	-1.3	0.5	-0.5
Neuroticism score	0.8	1.6	4.1	-0.5	0.1	-0.2	-1.9	2.0
Birth weight of first child	0.8	1.4	5.3	0.6	0.4	0.6	1.0	-2.3
Glaucoma (self-reported)	0.8	0.9	2.2	-1.2	0.8	0.3	-1.5	0.1
Medication: Amlodipine	0.8	1.2	3.5	-1.0	-0.7	-0.6	-1.9	0.8
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.3	-1.5	1.1	0.3	-1.0	0.1
Mean time to correctly identify matches	0.8	1.6	4.4	2.1	0.1	-0.1	1.9	0.1
Medication for cholesterol	0.8	1.2	2.8	1.7	-1.2	-0.3	1.1	-0.4
Osteoporosis (self-reported)	0.8	0.9	2.3	-0.9	-0.2	-0.9	-1.5	-0.9
Smoking status: Current	0.8	1.3	3.1	1.8	-0.2	-1.3	-0.0	-1.3
Depression (Nagel 2018)	0.7	1.0	3.2	1.0	-0.7	-0.7	0.2	-1.8
Hand grip strength (right)	0.7	1.8	2.9	1.7	-0.9	-0.7	1.6	-1.6
Current tobacco smoking	0.7	1.2	3.2	1.8	0.3	-0.7	0.3	-1.4
Stomach or abdominal pain in last month	0.7	0.8	1.8	0.1	-1.4	-1.2	-0.3	-0.9
Medication: Simvastatin	0.7	1.0	3.3	0.2	-0.1	0.4	1.8	1.2
Mouth/teeth dental problems: Dentures	0.7	1.2	2.8	0.2	-1.1	-1.7	-1.4	0.6
Medication: Lansoprazole	0.7	0.8	2.3	-0.1	-0.9	-1.5	-0.4	-0.7
Medication: Paracetamol	0.7	1.2	2.3	-1.5	-1.3	-1.2	-0.5	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.3	-0.5	-0.8	-1.1	-1.1	-1.1
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.7	0.2	1.3	1.1	0.4	1.0
Medication: Aspirin	0.7	0.9	2.4	-1.3	0.4	0.5	-0.1	1.5
Commuting to job workplace: Walk	0.7	0.7	1.6	0.2	-0.3	-0.8	-1.3	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	4.0	1.1	0.3	1.3	2.0	0.7
Commuting to job workplace: Public transport	0.7	0.8	1.6	1.0	0.5	0.6	1.2	-0.8
Alcohol drinker status: Never	0.7	0.8	2.5	-1.6	0.3	-0.4	-0.7	0.9
Basal cell carcinoma (self-reported)	0.7	0.8	2.2	0.5	0.7	0.1	1.0	-1.5
Depressed Affect (Nagel 2018)	0.6	1.3	3.7	-0.1	1.1	0.8	-0.9	1.9
Coronary Artery Disease (CAD)	0.6	0.7	1.2	0.2	-1.1	-0.9	1.0	-0.8
Lung FEV1/FVC ratio	0.6	2.9	9.3	1.0	0.4	1.7	3.0	-1.1
Chronotype (morning person)	0.6	1.3	2.9	1.3	-1.7	-0.9	0.2	1.1
Maternal smoking around birth	0.6	0.8	2.6	0.8	-1.6	-0.9	-0.3	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.4	1.3	0.7	1.2	1.5	-0.5
Illnesses of siblings	0.6	0.9	1.5	-1.0	1.2	1.2	-0.7	0.4
Hair/balding pattern: Pattern 3	0.6	0.9	3.0	-0.9	0.7	-0.4	-1.7	0.4
Illnesses of mother	0.6	0.8	1.5	0.0	1.1	1.2	0.5	-1.0
Breastfed as a baby	0.6	0.8	1.8	-1.4	-0.7	-0.4	-1.0	0.7
Health satisfaction	0.6	0.7	1.4	0.3	1.0	0.6	0.8	-1.2
Overall health rating	0.6	1.3	4.8	-0.1	-0.5	-1.2	-0.3	-2.2
Long-standing illness, disability or infirmity	0.6	0.9	3.3	0.5	-0.3	-0.5	0.6	-1.8
Whole body water mass	0.6	3.2	5.8	2.4	1.3	0.6	1.9	-2.0
Miserableness	0.6	1.0	2.9	-0.9	0.6	0.6	-0.9	1.7
Wears glasses or contact lenses	0.6	0.7	2.0	0.9	0.5	0.6	1.4	-0.1
Medication: Bendroflumethiazide	0.6	1.0	2.2	1.3	-0.9	-1.5	-0.4	0.1
Medication: Paracetamol	0.6	0.9	1.9	-1.2	-1.4	-1.0	-0.2	0.0
Vascular/heart problems diagnosed by doctor	0.6	1.7	3.0	0.3	1.6	1.7	1.0	-1.4
Heart disease (siblings)	0.6	0.7	2.4	0.3	-0.0	0.9	0.5	1.6
Bipolar Disorder (2018)	0.5	0.9	2.0	0.4	1.1	0.9	0.3	1.4
Schizophrenia vs Biploar Disorder	0.5	0.7	3.0	-1.7	0.3	-0.2	-0.0	-0.4
Worry (Nagel 2018)	0.5	1.0	1.9	-0.7	0.8	0.8	-1.4	1.1
Breast Cancer	0.5	1.2	3.3	-0.6	-1.2	-1.8	-0.8	-0.4
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.0	0.9	0.5	1.3	1.4	0.5
Ever used hormone-replacement therapy (HRT)	0.5	0.7	2.0	0.9	-0.4	-0.6	0.3	-1.4
Ever had hysterectomy (womb removed)	0.5	0.6	1.2	-0.7	0.5	1.1	0.5	0.8
Angina	0.5	0.6	1.4	-1.2	0.9	0.5	-0.5	0.7
Pack years adult smoking proportion	0.5	0.8	1.8	0.5	1.1	0.9	1.3	0.2
Leg fat-free mass (left)	0.5	2.7	5.2	1.6	1.5	0.9	1.6	-2.3
Trunk fat percentage	0.5	2.1	5.2	-2.0	-0.2	-1.0	-2.3	-0.7
Hayfever, allergic rhinitis or eczema	0.5	1.0	2.9	1.7	-1.0	-0.5	0.7	-0.7
Leg predicted mass (left)	0.5	2.7	5.3	1.6	1.4	0.8	1.7	-2.3
Hearing difficulty/problems with background noise	0.5	0.8	2.0	-0.4	1.4	0.2	-1.2	-0.4
Trunk fat-free mass	0.5	3.1	6.8	2.6	1.2	0.3	1.9	-1.9
Time employed in main current job	0.5	0.6	1.5	-1.2	0.4	0.5	-0.6	0.6
Qualifications: A levels/AS levels or equivalent	0.5	1.1	1.9	0.8	1.2	1.4	1.2	-0.1
Medication: Cholesterol lowering	0.5	0.8	3.0	0.7	-0.7	-0.1	1.7	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	4.3	1.8	0.0	0.5	2.1	-0.5
Pulse wave Arterial Stiffness index	0.5	0.6	1.8	-1.3	0.3	0.8	-0.3	0.4
Trunk predicted mass	0.5	3.0	6.4	2.5	1.3	0.3	1.9	-1.9
Hair/balding pattern: Pattern 4	0.5	1.2	3.3	1.6	0.0	0.3	1.8	-0.0
Loud music exposure frequency	0.5	0.5	1.3	0.4	-1.1	-1.0	0.0	-0.3
Forced vital capacity (FVC), Best measure	0.5	1.9	5.3	2.3	0.1	0.1	1.9	-0.7
Arm fat-free mass (right)	0.5	2.4	6.1	2.5	1.2	0.7	1.5	-1.4
Number of full brothers	0.5	0.7	1.8	-1.3	-0.0	0.4	-0.8	1.0
Number of children fathered	0.5	0.6	1.1	-1.0	0.3	-0.2	-1.0	0.7
Pulse wave peak to peak time	0.5	0.6	1.5	1.2	-0.3	-1.0	0.1	-0.5
Arm predicted mass (right)	0.5	2.4	5.5	2.4	1.5	0.8	1.4	-1.2
Supplements: Vitamin C	0.5	0.6	1.8	-0.9	-0.2	-0.7	-1.3	0.2
Whole body fat-free mass	0.5	3.0	5.4	2.3	1.3	0.5	1.9	-2.0
Leg fat-free mass (right)	0.5	2.7	4.0	1.9	1.4	1.0	1.8	-2.0
Handedness (chirality/laterality): Left-handed	0.5	0.7	2.2	-0.3	1.5	0.9	-0.0	-0.3
Mood swings	0.5	0.8	2.7	-0.3	0.0	-0.8	-1.6	0.8
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	2.6	-0.4	-0.5	-0.6	-0.9	-1.6
Leg predicted mass (right)	0.5	2.8	3.8	1.9	1.5	1.0	1.8	-2.0
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.7	-1.3	0.4	-0.1	-0.9	-0.8
Fractured/broken bones in last 5 years	0.5	0.7	1.8	-0.1	-0.4	-0.8	-1.4	0.8
Crohns Disease (2017)	0.4	0.9	1.8	-0.9	-1.4	-1.1	-0.5	0.4
Primary Biliary Cirrhosis	0.4	0.6	2.0	-0.4	0.8	0.4	-0.1	1.4
Blood Platelet Count	0.4	4.2	9.9	-2.3	-1.2	-1.9	-3.1	1.0
BMI	0.4	2.2	5.1	1.7	0.3	0.9	2.3	-1.5
Waist Hip Ratio (WHR)	0.4	1.7	7.6	-2.8	0.7	-0.0	0.5	0.4
Lung FVC	0.4	2.1	5.9	2.4	-0.8	0.1	1.9	0.5
Vitamin and mineral supplements	0.4	0.5	1.4	1.2	-0.2	0.0	1.0	-0.4
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.7	0.6	-0.8	-0.7	0.3	-0.7
Body mass index (BMI)	0.4	1.6	3.8	0.8	0.8	1.5	1.9	-0.9
Nervous feelings	0.4	0.7	1.4	0.9	-0.5	-0.2	-1.0	1.2
Financial difficulties in last 2 years	0.4	0.5	1.1	0.2	-0.8	-0.9	0.0	-1.0
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	3.9	1.4	-0.3	0.2	2.0	-0.7
Standing height	0.4	4.0	8.8	-0.2	0.4	-2.6	-3.0	-2.1
Peak expiratory flow (PEF)	0.4	1.0	1.8	1.3	-0.1	-0.0	1.2	-1.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.6	1.3	-0.3	-0.3	0.7	1.0
Age at first live birth	0.4	0.8	1.5	0.5	1.1	1.2	0.8	-0.4
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.6	-0.8	-0.8	-0.6	-0.8	-0.0
Medication for pain relief, constipation, heartburn	0.4	0.7	3.3	1.8	-0.2	-0.1	0.3	-0.5
Heart disease (mother)	0.4	0.5	0.9	-0.2	-0.9	-0.5	0.7	-1.0
Comparative height size at age 10	0.4	2.2	5.0	-0.8	0.7	-1.2	-1.9	-2.2
Knee pain experienced in last month	0.4	0.7	1.1	0.8	-1.0	-1.0	-0.2	0.8
Loneliness, isolation	0.4	0.6	1.2	-0.7	0.9	1.1	-0.2	0.5
Qualifications: nursing, teaching	0.4	0.6	1.3	-0.6	-0.0	-0.0	1.1	-1.1
Eye problems/disorders: Cataract	0.4	0.4	0.8	0.7	-0.9	-0.9	-0.5	-0.1
Medication: Aspirin	0.4	0.5	1.2	-1.0	0.3	0.6	0.2	1.1
Medication: Lisinopril	0.4	0.5	1.0	-0.7	-0.5	-0.8	-1.0	0.3
Basal metabolic rate	0.4	2.0	3.5	1.8	1.2	0.4	1.3	-1.9
Arm fat-free mass (left)	0.4	1.9	3.1	1.8	1.6	0.9	1.4	-1.1
Age started oral contraceptive pill	0.4	0.5	1.4	0.1	0.8	0.5	1.2	-0.3
Arm predicted mass (left)	0.4	1.9	3.4	1.9	1.4	0.8	1.5	-1.1
Alzheimer’s Disease (in father)	0.3	0.3	0.8	-0.6	0.9	-0.1	-0.2	0.6
Rheumatoid Arthritis	0.3	0.5	1.8	1.3	-0.5	-0.4	0.3	0.2
Heel T-Score	0.3	2.6	5.4	1.5	0.9	2.3	2.0	0.5
Height	0.3	5.7	13.8	-0.5	0.7	-2.6	-3.7	-2.7
Average weekly spirits intake	0.3	0.4	0.7	-0.6	0.9	-0.5	-0.3	-0.7
Hearing difficulty/problems: Yes	0.3	0.5	0.9	0.9	0.5	-0.3	-0.6	-0.9
Relative age of first facial hair	0.3	0.7	1.7	1.3	0.1	-0.7	0.8	-0.8
Multivitamins +/- minerals	0.3	0.4	0.7	0.3	0.8	0.8	0.6	-0.3
Chronic bronchitis/emphysema (father)	0.3	0.3	1.0	0.4	-0.6	-0.3	0.2	-1.0
Hip circumference	0.3	1.4	3.5	0.6	-0.3	-1.2	-1.4	-1.9
Worrier / anxious feelings	0.3	0.7	1.5	-0.8	0.1	-0.9	-1.2	-0.5
Pulse rate	0.3	0.4	0.8	0.0	0.6	0.9	0.5	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.4	-1.2	-0.3	-0.4	-0.7	-0.2
Exposure to tobacco smoke at home	0.3	0.4	0.6	-0.0	-0.4	-0.7	-0.8	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.7	-0.5	0.7	0.9	-0.3	-0.6
Shortness of breath walking on level ground	0.3	0.3	0.7	0.7	-0.3	-0.2	-0.8	0.5
Angina (self-reported)	0.3	0.4	0.6	-0.8	0.7	0.4	-0.3	0.6
Migraine (self-reported)	0.3	0.4	0.7	-0.1	-0.8	-0.8	-0.0	-0.8
Medication: Ibuprofen	0.3	0.3	0.5	-0.7	-0.6	-0.5	-0.0	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.9	-0.0	-0.9	-0.4	-0.1	0.7
Number of full sisters	0.3	0.3	0.7	-0.7	-0.5	-0.8	-0.3	0.2
Suffer from ‘nerves’	0.3	0.5	1.1	0.3	-0.4	-0.5	-1.1	0.9
Financial situation satisfaction	0.3	0.4	0.9	0.0	0.8	0.4	0.2	-1.0
Medication: Blood pressure	0.3	0.5	1.4	-0.6	-0.5	-1.2	-0.8	0.4
Diastolic blood pressure, automated reading	0.3	0.8	1.8	-0.5	-1.0	-1.3	-1.0	0.3
Commuting to job workplace: Cycle	0.3	0.3	0.6	-0.0	0.8	0.6	0.1	-0.8
Bipolar Disorder or Schizophrenia	0.2	0.6	1.7	0.0	0.9	0.6	-0.2	1.3
Irritable Bowel Disease (IBD)	0.2	0.5	1.2	-0.1	-1.1	-0.4	0.3	-0.9
Ulcerative Colitis (UC)	0.2	0.4	1.0	0.8	-0.5	0.2	0.4	-1.0
Major Depression (MDD)	0.2	0.3	0.6	-0.7	0.3	0.8	-0.5	-0.4
Ovarian Cancer	0.2	0.3	0.9	0.2	-0.1	-0.6	-0.3	-1.0
Fasting Glucose	0.2	0.2	0.6	0.8	0.5	0.2	0.3	0.1
Schizophrenia (2014)	0.2	0.5	1.0	-1.0	0.8	0.4	-0.5	0.7
Blood Red Count	0.2	2.4	5.6	-2.4	1.3	0.9	-1.4	1.4
Systolic blood pressure, automated reading	0.2	0.7	1.7	0.7	-0.3	-1.0	-0.7	1.3
Fed-up feelings	0.2	0.4	0.8	0.6	0.2	-0.4	-0.9	0.7
Relative age voice broke	0.2	0.2	0.9	1.0	0.4	-0.2	0.3	0.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.7	-0.1	-0.8	-0.3	-0.2	0.8
Trunk fat mass	0.2	1.1	2.0	-1.0	0.2	-0.7	-1.4	-1.4
Had menopause	0.2	0.2	0.7	-0.2	-0.3	0.0	-0.8	0.4
Forced vital capacity (FVC)	0.2	0.8	2.1	1.5	-0.4	-0.5	1.1	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.2	0.6	0.1	1.1	0.7	0.2
Heart attack	0.2	0.2	0.5	-0.1	-0.3	0.1	0.6	0.7
Weight	0.2	0.8	2.8	0.6	0.9	0.2	0.3	-1.7
Pulse wave reflection index	0.2	0.3	0.6	-0.4	-0.4	0.1	0.8	-0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.9	-0.6	-0.4	-0.3	-0.9	0.7
Body fat percentage	0.2	0.9	2.1	-1.4	-0.1	-0.5	-1.4	-0.6
Exposure to tobacco smoke outside home	0.2	0.3	1.0	-0.4	1.0	0.0	-0.3	-0.1
Worry too long after embarrassment	0.2	0.4	0.6	0.3	-0.8	-0.6	-0.6	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.0	-0.4	-0.5	-1.0	-0.8	0.3
Average weekly red wine intake	0.2	0.3	0.8	0.9	0.7	0.2	0.6	0.3
Friendships satisfaction	0.2	0.3	0.9	-1.0	-0.3	0.2	0.5	0.1
Breast cancer (self-reported)	0.2	0.3	0.6	-0.8	0.1	0.3	0.2	0.7
Osteoarthritis (self-reported)	0.2	0.2	0.5	0.0	0.0	0.4	0.7	0.7
Hearing aid user	0.2	0.3	0.4	0.0	-0.7	-0.6	0.4	-0.6
Eye problems/disorders: Glaucoma	0.2	0.3	0.8	-0.8	0.1	-0.0	-0.9	0.1
High cholesterol (Self-reported)	0.2	0.4	1.8	-0.5	-0.1	-0.3	0.1	1.3
Medication: Atorvastatin	0.2	0.3	1.2	-1.1	0.4	0.2	-0.3	-0.1
Number of operations (self-reported)	0.2	0.3	0.5	0.5	-0.1	-0.6	-0.7	-0.4
Cholesterol lowering medication	0.2	0.2	0.6	-0.6	0.2	-0.2	0.4	0.8
Pain experienced in last month	0.2	0.3	1.2	0.1	0.5	0.3	0.0	1.1
Supplements: Calcium	0.2	0.2	0.5	-0.7	-0.2	0.1	-0.3	0.6
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.9	0.0	-0.3	0.1	0.6	1.0
Pack years of smoking	0.2	0.3	0.8	0.5	0.7	0.3	0.9	0.2
Schizophrenia (2018)	0.1	0.1	0.3	-0.3	0.3	0.1	-0.5	0.5
Bipolar Disorder (2011)	0.1	0.1	0.3	-0.5	0.0	-0.2	0.0	0.0
Blood Eosinophil Count	0.1	0.6	2.5	1.6	0.0	-0.3	-0.1	-0.8
Hypothyroidism (self reported)	0.1	0.3	0.9	-0.5	-0.2	-0.2	-0.5	0.9
Hair Pigment	0.1	2.1	5.1	-1.9	-0.0	-1.1	-2.3	-0.9
Medication: Metformin	0.1	0.2	0.6	0.3	0.2	0.8	0.3	-0.2
Diabetes (mother)	0.1	0.1	0.5	0.7	0.4	0.1	-0.0	-0.1
Taking other prescription medications	0.1	0.2	0.5	-0.7	-0.0	0.1	0.0	-0.7
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	-0.1	0.0	0.1	-0.3	0.5
Medication: Levothyroxine sodium	0.1	0.2	0.3	0.6	-0.4	-0.5	-0.4	0.3
Sitting height	0.1	0.7	1.7	1.3	0.8	-0.6	-0.6	-0.6
Waist circumference	0.1	0.3	0.9	-0.4	0.4	-0.2	-0.4	-1.0
Alcohol usually taken with meals	0.1	0.2	0.5	0.4	-0.2	-0.1	0.7	-0.6
Had other major operations	0.1	0.2	0.4	0.5	0.6	0.0	0.0	0.5
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.1	-0.3	-0.3	-0.2	-0.4	-0.3
Arm fat percentage (right)	0.1	0.5	1.3	-1.0	0.1	0.1	0.4	-1.2
Arm fat mass (right)	0.1	0.5	1.7	-0.4	0.5	0.3	0.5	-1.3
High blood pressure (siblings)	0.1	0.1	0.4	0.3	0.1	-0.6	0.2	0.3
Leg fat percentage (right)	0.1	0.4	0.9	-0.9	0.0	-0.2	-0.9	-0.6
Whole body fat mass	0.1	0.5	1.8	-0.6	0.2	-0.3	-0.5	-1.3
Leg fat mass (right)	0.1	0.3	1.1	-0.3	0.5	0.3	-0.0	-1.0
Pulse rate, automated reading	0.1	0.2	0.5	-0.7	-0.1	-0.6	-0.3	0.5
Arm fat percentage (left)	0.1	0.5	1.8	-0.8	0.1	0.1	0.2	-1.3
Arm fat mass (left)	0.1	0.6	2.2	-0.2	0.6	0.3	0.5	-1.5
Number of self-reported non-cancer illnesses	0.1	0.2	0.6	-0.8	0.2	0.1	0.2	-0.5
Average weekly champagne plus white wine intake	0.1	0.2	0.4	0.7	0.2	-0.2	0.6	-0.0
Leg fat percentage (left)	0.1	0.4	1.0	-0.9	0.2	0.2	-1.0	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.6	-0.1	-0.2	-0.8	-0.4	-0.1
Leg fat mass (left)	0.1	0.3	0.8	-0.2	0.7	0.5	-0.1	-0.9
Tanning	0.0	0.4	0.9	0.3	-0.9	-0.0	-0.4	0.9
Number of live births	0.0	0.0	0.1	0.1	0.1	0.1	-0.3	0.1
Medication: Omeprazole	0.0	0.0	0.0	0.1	-0.1	-0.2	0.1	0.2

Hub : Genes

NSUN5P2

Models

Trait associations