Hub : Genes

CD274

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.244	0.0400	1.1e-16	0.165	0.166	0.152	0.176	0.181	1.3e-19	1.0e-19	4.6e-18	6.2e-21	1.5e-21
2	GTEx	Brain Cerebellar Hemisphere	0.442	0.0900	2.4e-05	0.364	NA	0.194	NA	0.259	3.1e-10	NA	1.1e-05	NA	2.4e-07
3	GTEx	Pancreas	0.516	0.0800	2.6e-08	0.271	NA	0.313	NA	0.314	7.4e-12	NA	8.7e-14	NA	7.6e-14
4	ROSMAP	Brain Pre-frontal Cortex	0.108	0.0274	3.7e-07	0.094	0.054	0.101	0.075	0.111	4.1e-12	1.6e-07	6.8e-13	5.8e-10	3.8e-14
5	TCGA	Breast Invasive Carcinoma	0.043	0.0199	1.3e-03	0.004	0.027	0.023	NA	0.012	4.1e-02	2.5e-06	1.2e-05	NA	1.5e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.4	0.6	0.9	-0.9	-0.7	0.8	-0.7	-0.4
Bipolar Disorder or Schizophrenia	0.3	0.8	1.5	-0.8	-1.2	0.7	-1.0	-0.5
Depressed Affect (Nagel 2018)	2.6	5.4	10.6	3.1	1.7	-3.3	1.9	-0.3
Depression (Nagel 2018)	1.2	1.8	4.2	1.7	0.5	-2.0	1.2	-0.3
Intelligence (Savage-Jansen 2018)	0.4	1.2	1.8	1.1	0.8	-1.3	0.8	1.4
Neuroticism (Nagel 2018)	1.9	4.5	9.5	2.7	1.6	-3.1	1.7	0.5
Schizophrenia (2018)	0.2	0.3	1.0	-0.3	-1.0	0.3	-0.6	-0.3
Schizophrenia vs Biploar Disorder	0.1	0.2	0.4	0.6	0.0	-0.5	0.5	0.2
Worry (Nagel 2018)	1.5	3.2	5.9	2.1	1.6	-2.4	1.4	1.0
Alzheimer’s Disease (in mother)	0.1	0.2	0.4	-0.1	0.1	0.3	-0.6	-0.7
Alzheimer’s Disease (in father)	0.1	0.1	0.3	0.3	0.3	-0.3	0.6	0.1
Alzheimer’s Disease (including proxy)	0.4	0.6	1.0	1.0	0.8	-0.7	0.9	-0.4
Crohns Disease (2017)	0.6	1.3	2.7	-1.6	-1.3	1.1	-1.1	-0.3
Irritable Bowel Disease (IBD)	4.7	11.3	20.6	-3.5	-4.5	2.3	-2.9	-3.1
Ulcerative Colitis (UC)	9.4	17.6	31.4	-4.0	-5.6	2.8	-3.5	-4.5
Major Depression (MDD)	0.2	0.2	0.9	-0.2	-0.9	0.0	0.4	-0.3
Reaction Time	0.3	0.6	2.3	-0.1	-0.7	-0.2	0.1	-1.5
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.9	0.5	0.8	-0.5	-0.0	1.4
Breast Cancer	0.3	0.6	1.7	-1.1	-1.3	0.3	-0.5	-0.2
Ovarian Cancer	0.6	0.8	2.6	0.0	-1.6	-0.6	0.4	-0.9
Prostate Cancer	0.7	1.0	1.3	0.9	1.0	-0.9	1.1	1.1
Age at First Birth	0.3	0.5	0.7	-0.6	-0.8	0.6	-0.8	-0.7
Bipolar Disorder (2011)	0.8	0.7	1.0	-1.0	-0.7	1.0	-0.8	-0.8
Body Mass Index (BMI) (2010)	0.3	0.4	1.1	0.6	0.4	-0.5	0.4	-1.1
Coronary Artery Disease (CAD)	0.8	1.0	2.0	0.7	-1.4	-0.9	0.9	-0.9
Crohns Disease (2012)	0.4	0.6	1.1	-1.0	0.2	0.8	-1.0	0.7
Mean Putamen Volume	0.9	1.0	1.8	-1.1	-0.5	1.3	-1.3	-0.4
Fasting Glucose	0.1	0.1	0.3	0.4	0.2	0.0	-0.3	-0.5
HbA1C	1.6	1.7	3.2	1.8	0.9	-1.6	1.2	-0.7
HDL Cholesterol	0.0	0.0	0.1	-0.2	0.0	0.0	-0.3	-0.2
LDL Cholesterol	0.5	0.8	1.7	-1.1	-0.3	1.3	-0.8	0.5
Lupus	0.3	0.5	0.8	0.5	-0.8	-0.9	0.5	-0.8
Neuroticism (2016)	1.1	1.6	4.5	1.2	2.1	-0.7	0.3	1.3
Primary Biliary Cirrhosis	0.7	1.0	2.3	-0.8	0.1	1.0	-0.9	1.5
Rheumatoid Arthritis	1.8	2.4	10.6	0.2	0.8	-0.9	0.4	3.3
Schizophrenia (2014)	0.2	0.5	0.8	-0.8	-0.9	0.6	-0.8	0.3
Triglycerides	0.3	0.5	0.9	-1.0	-0.5	0.9	-0.8	-0.0
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.9	-0.1	0.9	0.4	0.3	0.9
Ulcerative Colitis	7.5	10.9	20.4	-3.2	-4.5	2.0	-3.1	-3.2
Blood Eosinophil Count	1.3	10.3	20.8	-2.6	-4.1	1.6	-2.3	-4.6
Blood Platelet Count	0.9	10.8	14.2	3.4	2.1	-3.8	3.2	3.6
Blood Red Count	0.1	1.4	5.9	0.1	-1.1	-0.4	0.1	-2.4
Blood White Count	0.3	2.4	4.1	-1.3	-1.8	0.6	-1.6	-2.0
Heel T-Score	0.1	0.5	1.4	0.9	0.5	-0.4	1.2	0.1
BMI	0.1	0.5	1.7	-0.5	-0.3	0.7	-0.5	-1.3
Height	0.0	0.2	0.6	-0.6	-0.2	0.8	-0.4	0.4
Waist Hip Ratio (WHR)	1.1	5.2	7.8	2.4	2.8	-2.5	1.5	2.0
Systolic Blood Pressure	0.3	1.7	2.8	-1.7	-0.2	1.6	-1.6	0.8
Smoking Status	0.5	1.3	1.7	-1.3	-1.2	1.1	-1.2	-0.8
Allergy or Eczema	0.5	1.4	4.6	-0.3	-2.1	-0.4	-0.1	-1.5
Cardiovascular Disease	0.4	1.2	3.0	1.0	1.7	-0.8	0.8	0.8
Hypothyroidism (self reported)	9.2	21.2	28.5	5.0	4.2	-5.3	4.6	3.7
Respiratory disease	0.5	1.0	2.4	0.8	-1.0	-1.0	0.5	-1.5
Type 2 Diabetes (T2D) (2018)	0.3	0.5	0.8	-0.5	-0.4	0.9	-0.9	-0.7
Lung FEV1/FVC ratio	0.3	1.3	2.0	1.2	1.2	-1.4	1.1	0.7
Lung FVC	0.2	1.1	1.8	0.9	-1.1	-1.0	1.4	-0.7
Neuroticism	1.5	3.5	7.1	2.3	1.1	-2.7	1.9	0.3
Chronotype (morning person)	0.5	1.1	1.8	1.1	1.3	-1.1	1.1	0.6
Hair Pigment	0.0	0.3	0.6	-0.5	-0.8	-0.2	-0.5	0.3
Tanning	0.0	0.1	0.2	-0.2	-0.5	0.2	-0.3	0.2
Hand grip strength (left)	0.1	0.3	0.8	-0.7	0.0	0.4	-0.5	0.9
Number of treatments/medications taken	1.0	1.8	3.9	1.0	-1.2	-1.2	1.0	-2.0
Average weekly spirits intake	1.9	2.4	3.8	1.7	1.3	-1.9	1.6	0.8
Sensitivity / hurt feelings	0.2	0.4	0.9	0.4	-0.5	-0.8	0.4	-1.0
Frequency of depressed mood in last 2 weeks	1.1	1.6	3.1	1.6	0.9	-1.8	1.1	-0.5
Hearing difficulty/problems: Yes	2.2	3.4	6.2	2.5	2.2	-1.9	1.5	-0.0
Relative age of first facial hair	0.9	1.8	3.3	-0.9	1.2	1.3	-1.4	1.8
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.9	-0.7	-0.8	0.2	-1.4	-1.1
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	0.5	0.4	-0.2	0.2	-0.5
Ever had hysterectomy (womb removed)	0.4	0.4	1.1	0.3	1.0	0.0	0.1	1.0
Systolic blood pressure, automated reading	0.4	1.1	2.3	-1.2	-0.3	1.0	-1.5	0.7
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	0.0	-0.3	-0.1	-0.2	-0.5
Angina	1.2	1.6	3.2	1.7	0.3	-1.8	1.3	0.0
Medication for hormone replacement therapy	0.7	0.8	2.2	0.7	0.0	-1.0	0.7	-1.5
Vitamin and mineral supplements	1.5	2.0	4.0	-1.6	0.1	1.9	-2.0	0.0
Supplements: Zinc	0.7	0.7	1.4	0.8	0.2	-1.2	1.2	-0.3
Medication: Co-codamol	1.6	1.8	3.1	1.8	1.5	-1.3	1.3	-0.3
Medication: Metformin	0.0	0.0	0.1	-0.1	-0.0	0.3	-0.1	0.1
Diabetes (father)	1.3	1.6	3.6	1.0	1.7	-0.5	0.6	1.9
Diabetes (mother)	1.0	1.2	3.1	1.1	1.8	-0.8	1.1	0.2
Severe depression (siblings)	0.7	0.8	2.8	-0.4	-0.9	0.3	-0.3	-1.7
Pack years adult smoking proportion	0.4	0.6	1.6	0.7	0.4	-0.7	1.3	-0.3
Impedance of leg (right)	0.1	0.6	1.4	0.6	1.0	-0.1	0.4	1.2
Leg fat-free mass (left)	0.1	0.6	1.5	-1.2	-0.7	0.7	-0.7	-0.3
Trunk fat percentage	0.0	0.1	0.2	-0.4	-0.1	0.4	-0.3	-0.4
Hand grip strength (right)	0.2	0.5	1.6	-0.4	0.6	-0.1	-0.6	1.3
Townsend deprivation index at recruitment	3.0	4.2	8.9	2.0	3.0	-1.5	1.7	1.7
Current tobacco smoking	0.1	0.2	0.9	-0.3	0.3	0.1	0.1	0.9
Average weekly fortified wine intake	1.7	2.0	3.4	1.6	0.5	-1.8	1.8	0.5
Maternal smoking around birth	0.8	1.2	1.7	-1.1	-1.3	1.1	-1.0	-1.0
Fed-up feelings	1.2	2.2	4.2	2.0	1.3	-2.1	1.0	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.8	0.9	0.0	-1.4	1.1	-0.7
Relative age voice broke	1.0	1.5	2.3	-1.5	-0.9	1.5	-1.3	-0.6
Taking other prescription medications	1.7	2.6	4.6	1.8	-0.7	-2.1	1.1	-1.9
Age when periods started (menarche)	0.3	0.8	1.7	0.9	0.7	-1.3	0.8	-0.1
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	3.0	-1.5	-0.5	1.7	-1.7	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.7	0.3	0.4	0.2	0.1	-0.8
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.4	0.9	0.5	-1.0	1.2	-0.2
Qualifications: CSEs or equivalent	0.1	0.1	0.2	0.0	0.4	-0.4	0.4	-0.1
Serious illness, injury or assault to yourself	1.0	1.2	1.9	-1.4	-0.6	1.4	-1.3	-0.3
High blood pressure	0.4	1.0	1.7	1.3	1.3	-0.9	0.9	0.3
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.0	0.0	-1.0	-0.7	0.2	-0.7
Multivitamins +/- minerals	1.0	1.3	2.4	1.3	-0.0	-1.6	1.5	-0.1
Stomach or abdominal pain in last month	2.0	2.5	3.3	-1.3	-1.2	1.6	-1.8	-1.8
Supplements: Glucosamine	1.1	1.4	4.2	0.1	-1.6	-0.4	0.1	-2.1
Diverticular disease/diverticulitis (self-reported)	2.9	3.5	6.1	-2.5	-1.0	2.2	-2.2	-0.5
Medication: Atenolol	0.5	0.7	1.5	1.2	1.0	-0.4	0.8	-0.5
Medication: Levothyroxine sodium	4.1	6.9	10.2	2.7	2.3	-3.2	2.5	2.2
Sitting height	0.0	0.1	0.2	0.2	0.4	-0.1	-0.3	0.4
Chronic bronchitis/emphysema (father)	0.3	0.4	0.6	0.3	0.8	-0.5	0.7	0.7
High blood pressure (mother)	0.7	0.9	3.0	-1.0	-1.7	0.5	-0.4	-0.3
Body mass index (BMI)	0.1	0.3	0.5	-0.7	-0.7	0.4	-0.1	-0.5
Impedance of leg (left)	0.4	1.7	3.0	1.3	1.7	-0.8	0.8	1.7
Leg predicted mass (left)	0.1	0.6	1.5	-1.2	-0.7	0.7	-0.7	-0.3
Trunk fat mass	0.0	0.1	0.2	-0.5	-0.1	0.3	-0.3	-0.3
Waist circumference	0.1	0.2	0.3	0.5	0.6	-0.6	0.2	0.2
Number of incorrect matches in round	0.1	0.2	0.4	-0.6	0.2	0.6	-0.6	0.2
Past tobacco smoking	0.5	0.9	1.7	0.6	0.6	-1.3	1.2	0.7
Alcohol usually taken with meals	1.9	3.2	5.2	-1.7	-2.3	1.2	-1.8	-1.7
Nervous feelings	2.4	4.5	8.6	2.6	1.7	-2.9	1.8	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.9	1.2	-0.4	-1.7	0.9	-0.9
Hearing difficulty/problems with background noise	1.0	1.6	3.1	1.8	0.9	-1.7	1.0	-0.6
Hair/balding pattern: Pattern 2	0.9	1.1	3.5	0.1	-1.4	-0.5	0.2	-1.9
Had menopause	0.6	0.7	1.0	-0.8	0.4	0.9	-1.0	1.0
Had other major operations	0.8	1.0	1.4	-1.1	-0.9	1.2	-1.0	-0.6
Forced vital capacity (FVC)	0.1	0.5	0.8	-0.9	-0.7	0.9	-0.7	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.5	-0.1	0.2	0.6	-0.4	-0.7
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.9	0.2	1.0	-0.2	-0.3	0.5
Qualifications: None of the above	0.6	1.2	2.2	1.5	1.4	-1.1	0.9	-0.1
Financial difficulties in last 2 years	0.6	0.8	1.5	0.9	0.6	-0.9	1.2	-0.5
Mouth/teeth dental problems	0.1	0.2	0.5	0.0	0.0	-0.4	0.7	0.5
Heart attack	0.5	0.6	0.9	0.9	0.7	-0.6	0.9	0.7
Allergy	0.5	1.2	3.7	0.1	1.3	0.3	0.5	1.9
Pain all over the body in last month	0.7	0.7	1.7	0.1	-1.0	-0.8	1.3	-0.6
Diabetes (self-reported)	0.1	0.2	0.4	0.4	-0.5	-0.3	0.3	-0.6
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	2.4	-1.1	-1.6	0.9	-0.5	-0.7
Medication: Ramipril	0.2	0.3	0.6	-0.1	0.4	0.8	-0.5	-0.6
Medication: Simvastatin	0.1	0.2	0.3	-0.3	-0.6	0.5	-0.4	-0.2
Fluid intelligence score	0.1	0.2	0.5	0.7	0.7	-0.4	0.0	0.4
Illnesses of siblings	0.8	1.1	2.4	-1.0	-1.6	0.8	-0.3	-1.3
Neuroticism score	1.6	3.4	7.4	2.3	1.3	-2.7	1.5	0.1
Weight	0.1	0.6	1.3	-1.1	-0.6	0.8	-0.8	-0.0
Impedance of arm (right)	0.2	0.9	1.7	-1.1	-0.4	1.2	-1.3	-0.2
Arm fat percentage (right)	0.1	0.2	0.5	-0.7	-0.5	0.4	-0.1	-0.5
Trunk fat-free mass	0.0	0.1	0.2	-0.4	-0.2	0.1	-0.2	0.5
Hip circumference	0.3	1.3	1.7	-1.2	-1.3	1.0	-1.0	-1.1
Time employed in main current job	0.2	0.2	0.7	0.3	-0.0	-0.8	0.0	-0.4
Alcohol intake versus 10 years previously	0.2	0.3	0.6	0.7	0.0	-0.8	0.6	-0.4
Father’s age at death	0.1	0.2	0.9	-0.0	-1.0	0.0	0.0	-0.2
Worrier / anxious feelings	0.6	1.1	2.2	1.2	1.5	-1.3	0.3	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.7	1.7	0.7	-0.6	-0.9	0.5	-1.3
Falls in the last year	0.1	0.1	0.3	0.0	0.4	-0.3	0.1	0.5
Hair/balding pattern: Pattern 3	0.3	0.5	0.9	-0.8	-0.1	1.0	-0.7	0.5
Number of live births	0.1	0.2	0.3	0.5	0.4	-0.3	0.6	0.2
Forced expiratory volume in 1-second (FEV1)	0.0	0.0	0.1	-0.3	-0.0	0.3	-0.2	-0.1
Pulse rate	0.0	0.0	0.1	0.1	-0.2	-0.1	0.3	0.0
Happiness	1.2	1.5	2.4	1.6	0.6	-1.4	0.8	-1.3
Noisy workplace	0.4	0.5	1.0	0.8	0.3	-1.0	0.7	0.7
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.0	0.2	-1.0	-0.4	0.5	-1.4
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.6	0.7	0.4	-0.7	0.4	-0.1
Mouth/teeth dental problems: Dentures	0.3	0.6	1.5	0.6	0.9	-0.2	0.3	1.2
Asthma	1.0	2.0	5.1	-0.7	-2.0	0.1	-0.6	-2.3
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.7	-0.5	-1.4	0.4	-0.4	-1.7
Medication: Cholesterol lowering	0.2	0.3	0.7	0.8	0.5	-0.8	0.3	-0.1
Depression (self-reported)	1.9	2.3	5.0	-1.4	-2.2	1.1	-1.0	-1.4
Medication: Lansoprazole	0.4	0.5	1.5	0.9	1.2	-0.4	0.2	-0.0
Prospective memory result	1.0	1.2	2.0	1.0	1.0	-1.4	1.0	1.0
Lung cancer (father)	0.4	0.5	1.6	-0.2	-0.7	0.3	0.5	-1.3
Illnesses of mother	0.6	0.7	1.3	-0.9	-0.0	0.9	-1.2	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	1.9	0.7	1.4	-0.7	0.7	1.3
Pulse wave Arterial Stiffness index	0.0	0.0	0.1	-0.0	-0.1	-0.1	-0.3	-0.3
Impedance of arm (left)	0.1	0.6	1.2	-0.7	0.3	1.0	-1.1	0.5
Arm fat mass (right)	0.0	0.1	0.3	-0.6	-0.4	0.3	-0.0	-0.3
Trunk predicted mass	0.0	0.1	0.2	-0.5	-0.3	0.1	-0.2	0.4
Standing height	0.1	1.0	2.0	-1.1	0.0	0.9	-1.4	1.1
Length of working week for main job	0.4	0.5	1.3	-0.7	-0.1	1.1	-0.6	0.3
Exposure to tobacco smoke at home	0.2	0.2	0.8	-0.2	0.3	0.3	-0.9	-0.1
Breastfed as a baby	1.2	1.5	3.8	-1.0	-1.9	0.8	-0.5	-1.3
Tense / ‘highly strung’	0.4	0.7	1.6	0.5	-0.8	-0.9	0.1	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.5	0.6	0.2	-0.7	0.1	-0.4
Hair/balding pattern: Pattern 4	0.4	0.9	2.4	1.0	1.5	-0.7	0.6	0.5
Birth weight of first child	0.3	0.5	2.0	-0.3	-0.5	-0.0	-0.1	-1.4
Peak expiratory flow (PEF)	0.2	0.5	2.0	-0.1	-0.3	0.1	-0.4	-1.4
Pulse wave reflection index	0.1	0.1	0.2	0.2	-0.3	-0.4	0.4	0.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	0.5	0.3	-0.1	0.3	-0.1
Loud music exposure frequency	1.7	1.8	3.9	2.0	1.1	-1.5	1.3	-0.1
Qualifications: O levels/GCSEs or equivalent	1.5	2.3	6.8	-0.2	-2.6	-0.6	0.8	-2.0
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	3.1	-0.7	0.4	1.3	-1.8	-0.9
Blood clot in the leg (DVT)	0.9	1.1	4.2	-0.2	-0.3	0.4	-1.1	-2.0
Medication: Paracetamol	0.3	0.5	0.9	-0.4	-0.9	0.5	-0.2	-1.0
Headache pain in last month	0.0	0.1	0.2	-0.2	-0.4	0.2	-0.2	-0.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.4	-1.2	-0.3	0.9	-0.5	0.8
Glaucoma (self-reported)	0.6	0.7	1.9	1.2	1.4	-0.5	-0.1	-0.3
Gout (self-reported)	0.6	0.8	2.1	0.8	-0.6	-0.9	1.4	0.3
Hypothyroidism/myxoedema (self-reported)	8.5	16.6	20.6	4.3	4.1	-4.5	3.6	3.7
Medication: Amlodipine	1.4	2.0	3.8	1.4	1.3	-1.9	1.2	1.0
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.7	-0.2	-0.9	-0.1	0.1	-1.3
Birth weight	0.8	1.8	3.5	1.5	0.7	-1.6	1.9	0.4
Chronic bronchitis/emphysema (mother)	1.2	1.3	2.6	1.1	0.4	-0.9	1.6	-1.4
High blood pressure (siblings)	0.5	0.7	2.0	0.5	0.9	-0.8	0.3	1.4
Forced vital capacity (FVC), Best measure	0.1	0.4	1.2	-0.0	0.8	0.0	-0.1	1.1
Body fat percentage	0.0	0.1	0.1	-0.3	0.1	0.3	-0.2	-0.1
Leg fat percentage (right)	0.0	0.0	0.1	-0.1	0.3	0.2	0.1	0.0
Arm fat-free mass (right)	0.0	0.1	0.3	-0.2	0.0	-0.1	0.1	0.5
Exposure to tobacco smoke outside home	0.5	0.7	2.2	-0.4	0.8	0.5	-1.5	0.3
Comparative body size at age 10	0.2	0.4	1.4	-0.1	0.2	-0.2	0.8	1.2
Number of full brothers	1.6	2.0	2.8	1.7	0.9	-1.6	1.6	-1.1
Worry too long after embarrassment	0.3	0.5	1.1	0.6	0.6	-0.7	-0.1	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.4	0.9	0.7	-1.2	0.6	0.2
Wheeze or whistling in the chest in last year	0.7	1.3	3.4	-0.7	-1.3	0.4	-0.7	-1.8
Number of children fathered	0.6	0.6	1.2	0.6	0.3	-1.1	0.9	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.7	0.3	-0.4	-0.8	0.6	0.1
Age at first live birth	0.1	0.1	0.3	-0.5	-0.1	0.1	-0.5	-0.3
Pulse wave peak to peak time	0.0	0.0	0.1	-0.1	0.2	0.2	0.1	0.3
Health satisfaction	1.1	1.4	3.1	1.5	0.5	-1.8	1.2	-0.2
Shortness of breath walking on level ground	0.7	0.8	1.8	0.7	1.2	-0.5	0.2	1.4
Qualifications: College or University degree	0.1	0.3	0.6	-0.6	-0.2	0.7	-0.8	0.3
Eye problems/disorders: None of the above	0.7	0.8	1.7	-0.8	-1.3	0.5	0.9	-0.7
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.9	-0.3	-1.4	-0.3	0.2	-0.5
Emphysema/chronic bronchitis	0.2	0.2	0.6	-0.0	-0.7	0.2	-0.1	-0.7
Medication for pain relief, constipation, heartburn	0.8	1.5	3.2	0.6	1.8	-0.6	0.8	1.6
Neck or shoulder pain in last month	1.3	1.8	5.3	-0.4	-1.9	-0.0	-0.3	-2.3
Medication: Blood pressure	0.1	0.2	0.5	0.5	-0.2	-0.2	0.2	-0.7
Angina (self-reported)	1.6	2.1	4.2	2.0	0.7	-2.1	1.5	0.2
Migraine (self-reported)	1.0	1.2	4.4	-1.2	-2.1	0.4	-0.1	-0.4
Medication: Ibuprofen	2.0	2.4	5.0	-1.1	-2.2	0.7	-0.8	-2.1
Medication: Allopurinol	0.3	0.3	0.9	0.1	-0.3	-0.4	0.7	1.0
Medication: Omeprazole	0.4	0.5	0.8	0.8	0.6	-0.8	0.9	0.3
Medication: Seretide 50 evohaler	2.5	2.9	3.9	-1.8	-2.0	1.5	-2.0	-1.1
Mean time to correctly identify matches	0.3	0.6	2.1	-0.1	-0.7	0.0	-0.4	-1.5
Heart disease (mother)	0.1	0.1	0.2	0.1	-0.2	-0.1	0.4	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.5	0.2	0.3	-0.2	0.7	-0.2
Whole body fat mass	0.0	0.1	0.2	-0.5	-0.0	0.4	-0.3	-0.2
Leg fat mass (right)	0.0	0.0	0.1	-0.3	0.0	0.2	-0.0	-0.4
Arm predicted mass (right)	0.0	0.1	0.3	0.1	0.3	-0.4	0.3	0.6
Pulse rate, automated reading	0.4	1.4	3.2	-0.5	-1.6	0.4	-0.9	-1.8
Alcohol intake frequency.	0.7	1.7	3.0	1.1	-0.7	-1.7	1.2	-1.5
Comparative height size at age 10	0.3	1.4	2.3	-1.5	-1.2	1.3	-1.2	-0.1
Number of full sisters	1.7	2.1	6.1	1.3	2.5	-0.7	1.1	1.1
Suffer from ‘nerves’	0.5	0.7	1.6	0.8	0.6	-1.3	0.7	0.8
Overall health rating	1.4	3.1	5.2	2.1	1.7	-2.3	1.7	0.3
Chest pain or discomfort	1.7	2.5	7.2	0.5	-1.8	-1.1	0.3	-2.7
Had major operations	0.3	0.4	1.1	-0.1	-0.5	0.7	-0.0	-1.1
Age at last live birth	0.1	0.2	0.3	-0.3	0.4	0.2	-0.5	-0.5
Family relationship satisfaction	0.2	0.3	0.6	0.4	-0.3	-0.6	0.4	-0.8
Leg pain on walking	0.1	0.2	0.3	0.3	0.5	-0.2	0.4	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.2	-0.5	-0.1	0.2	0.3
Commuting to job workplace: Car/motor vehicle	1.7	1.9	2.2	-1.3	-1.4	1.5	-1.3	-1.5
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.7	0.6	0.5	-0.8	0.8	0.6
Medication: Aspirin	0.2	0.3	0.7	0.4	0.5	-0.0	-0.8	-0.4
Supplements: Vitamin C	0.1	0.1	0.1	-0.3	-0.2	0.1	-0.4	-0.2
Knee pain experienced in last month	1.0	1.5	5.7	0.1	-1.2	-0.2	-0.4	-2.4
Hypertension (Self-reported)	0.3	0.8	1.4	1.1	1.2	-0.8	0.9	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	1.6	1.2	1.0	-1.1	1.2	0.3
Illnesses of father: Heart disease	0.7	1.0	1.4	-1.2	-1.1	1.0	-0.9	-0.8
Illnesses of siblings: Diabetes	1.6	2.0	5.2	1.6	2.3	-1.0	0.3	1.1
Smoking status: Previous	1.4	2.0	3.6	-1.1	-1.2	1.7	-1.9	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.5	-0.6	0.8	0.8	-0.4	1.6
Whole body fat-free mass	0.0	0.2	0.6	-0.8	-0.5	0.3	-0.4	0.1
Leg fat-free mass (right)	0.1	0.6	1.4	-1.2	-0.7	0.6	-0.7	-0.2
Arm fat percentage (left)	0.1	0.2	0.5	-0.7	-0.4	0.5	-0.2	-0.4
Average weekly red wine intake	0.4	0.6	2.3	-0.2	0.4	0.3	-0.4	1.5
Handedness (chirality/laterality): Left-handed	1.0	1.2	2.6	-1.0	0.3	1.6	-1.4	0.0
Mood swings	0.6	1.1	2.0	1.4	0.8	-1.4	0.7	-0.3
Loneliness, isolation	2.5	3.4	6.0	2.3	1.9	-2.5	1.4	-0.2
Long-standing illness, disability or infirmity	0.5	0.7	1.9	1.2	0.2	-1.4	0.4	-0.2
Ever had bowel cancer screening	4.8	5.7	7.8	-2.5	-2.5	2.0	-2.8	-2.0
Diabetes diagnosed by doctor	0.1	0.2	0.3	-0.1	-0.6	0.3	-0.2	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.1	-0.1	0.2	0.0	0.1	0.1
Friendships satisfaction	0.2	0.3	0.9	0.4	0.1	-0.7	-0.2	-0.9
Qualifications: nursing, teaching	1.1	1.7	2.7	-1.6	-1.6	1.4	-1.1	-0.3
Commuting to job workplace: Walk	1.5	1.6	2.9	1.4	0.8	-1.5	1.7	0.4
Eye problems/disorders: Cataract	0.1	0.1	0.1	0.3	0.3	-0.4	-0.3	-0.3
Mouth/teeth dental problems: Mouth ulcers	1.0	1.5	2.1	-1.4	-1.3	1.3	-1.3	-0.5
Medication for cholesterol	0.0	0.1	0.2	-0.0	0.0	-0.1	-0.4	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.1	-0.3	-0.8	0.4	-0.9	-1.4
Back pain experienced in last month	0.2	0.3	1.0	0.3	-0.0	-0.2	0.5	-1.0
Mineral and other dietary supplements	1.3	1.7	4.7	0.1	2.2	0.3	-0.6	1.9
Breast cancer (self-reported)	0.1	0.1	0.6	0.2	0.8	-0.1	-0.2	0.1
Asthma (self-reported)	1.0	1.9	4.0	-1.0	-2.0	0.4	-0.9	-1.9
Osteoporosis (self-reported)	0.5	0.6	1.4	1.2	0.2	-0.9	0.8	0.2
Osteoarthritis (self-reported)	0.1	0.2	0.6	0.2	0.3	-0.1	0.3	-0.8
Medication: Aspirin	0.2	0.2	0.8	0.2	0.1	0.0	-0.9	-0.4
Medication: Gliclazide	1.3	1.5	2.9	1.7	0.9	-1.4	1.4	-0.2
Illnesses of father: None of the above (group 1)	0.3	0.4	0.5	-0.7	-0.4	0.7	-0.5	0.7
Smoking status: Current	0.4	0.6	1.6	0.3	1.0	-0.4	0.5	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.6	-0.4	-0.8	0.0	-0.7	-0.3
Whole body water mass	0.0	0.2	0.5	-0.7	-0.5	0.2	-0.3	0.0
Leg predicted mass (right)	0.1	0.6	1.5	-1.2	-0.7	0.7	-0.7	-0.2
Arm fat mass (left)	0.1	0.3	0.6	-0.8	-0.4	0.5	-0.3	-0.3
Number of self-reported non-cancer illnesses	1.2	2.0	3.8	1.9	0.3	-1.9	1.1	-1.2
Average weekly champagne plus white wine intake	0.3	0.5	1.6	-0.6	-1.3	-0.2	-0.3	-0.5
Miserableness	1.4	2.4	4.8	2.0	0.9	-2.2	1.4	-0.3
Guilty feelings	0.7	1.0	3.0	1.1	0.6	-1.7	0.3	0.7
Wears glasses or contact lenses	0.3	0.3	0.8	-0.2	0.4	0.5	-0.9	0.4
Ever taken oral contraceptive pill	2.2	2.5	3.9	1.4	2.0	-1.3	1.4	1.7
Hearing aid user	0.1	0.1	0.1	0.4	0.1	0.3	0.2	-0.1
Mother’s age at death	1.3	1.7	2.7	1.6	-0.1	-1.6	1.6	-0.9
Financial situation satisfaction	0.7	0.9	2.5	0.7	-0.3	-0.9	1.6	-0.8
Tinnitus: Yes, now most or all of the time	2.7	3.1	5.4	2.1	1.4	-2.3	1.6	1.2
Commuting to job workplace: Public transport	0.4	0.5	1.0	0.9	0.7	-1.0	0.5	-0.0
Eye problems/disorders: Glaucoma	0.3	0.3	1.0	0.6	0.3	0.1	-0.4	-1.0
Medication: Blood pressure	0.1	0.1	0.4	0.1	0.5	0.2	0.1	0.6
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.5	1.1	0.3	-1.2	0.5	-0.9
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.1	-0.0	-1.1	-0.5	0.9	-0.7
High cholesterol (Self-reported)	0.5	1.0	1.3	1.1	1.0	-1.1	1.1	0.1
Medication: Bendroflumethiazide	0.1	0.2	0.4	0.5	0.3	-0.2	0.3	-0.6
Medication: Paracetamol	0.1	0.1	0.2	0.3	-0.4	-0.1	0.3	-0.4
Medication: Lisinopril	0.5	0.6	1.0	-0.8	-0.6	0.7	-0.6	-1.0
Medication: Atorvastatin	0.2	0.3	0.6	0.3	0.8	-0.5	0.1	0.7
Illnesses of father: High blood pressure	0.1	0.2	0.4	-0.3	0.3	0.4	-0.7	-0.2
Alcohol drinker status: Never	0.8	0.9	2.2	1.4	0.5	-1.5	0.5	0.5
Ever smoked	0.1	0.2	0.5	0.0	0.2	0.7	-0.5	-0.2
Basal metabolic rate	0.0	0.2	0.5	-0.7	-0.3	0.2	-0.3	0.2
Leg fat percentage (left)	0.0	0.1	0.4	0.2	0.6	-0.2	0.3	0.2
Arm fat-free mass (left)	0.0	0.1	0.1	-0.4	-0.1	-0.0	-0.1	0.4
Number of operations (self-reported)	0.1	0.1	0.3	0.4	-0.1	-0.5	0.5	0.1
Average weekly beer plus cider intake	0.5	0.8	1.1	-0.9	-0.8	1.0	-0.9	-0.7
Irritability	0.8	1.4	3.0	1.5	0.1	-1.7	1.2	-0.7
Risk taking	0.4	0.6	1.3	-0.9	-0.3	1.1	-0.8	0.3
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	0.1	-0.3	-0.3	0.0	0.6
Fractured/broken bones in last 5 years	3.3	4.3	8.0	-2.7	-0.9	2.8	-2.2	0.7
Age started oral contraceptive pill	0.3	0.3	0.6	-0.7	-0.4	0.8	-0.6	-0.4
Diastolic blood pressure, automated reading	1.3	4.1	6.8	-2.6	-1.8	2.2	-2.4	-0.1
Ever depressed for a whole week	0.4	0.5	1.3	0.6	-0.4	-0.5	0.5	-1.2
Unable to work because of sickness or disability	0.9	1.1	2.5	1.3	0.7	-1.6	1.0	-0.3
Commuting to job workplace: Cycle	0.9	1.1	2.3	0.9	1.5	-1.0	0.6	1.0
Myopia	0.6	0.9	2.0	-0.8	0.8	1.1	-1.4	-0.0
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.0	-1.0	-0.9	0.7	-0.6	-0.0
Cholesterol lowering medication	0.3	0.4	1.0	-0.7	-1.0	0.4	-0.2	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.6	0.8	0.4	-0.7	0.8	0.2
Pain experienced in last month	0.5	0.8	2.6	0.3	0.9	-0.4	0.5	1.6
Supplements: Calcium	0.3	0.4	0.7	0.8	0.4	-0.6	0.7	0.4
Basal cell carcinoma (self-reported)	0.9	1.1	1.9	0.9	0.6	-1.4	0.7	1.3
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.4	1.2	0.7	-1.0	1.1	0.5
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	4.6	-0.2	-0.5	0.5	-1.2	-2.1
Heart disease (siblings)	0.8	1.0	1.8	1.0	1.3	-0.7	0.5	1.2
Alcohol drinker status: Previous	2.0	2.3	6.2	-1.1	-1.6	1.1	-0.7	-2.5
Pack years of smoking	0.5	0.7	1.6	0.9	0.3	-0.9	1.3	-0.4
Impedance of whole body	0.1	0.4	0.7	-0.1	0.8	0.5	-0.5	0.8
Leg fat mass (left)	0.0	0.1	0.1	0.1	0.3	-0.2	0.3	-0.1
Arm predicted mass (left)	0.0	0.0	0.1	-0.3	-0.1	-0.1	-0.0	0.2