[Hub]/) : Traits : Ulcerative Colitis (UC) : ← →

chr9:138,558,883-140,142,299

Best TWAS P=4.89e-16 · Best GWAS P=1.4e-16 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	INPP5E	0.18	0.14	enet	21	0.21	1.6e-24	5.04	-5.8	5.9e-09	-0.67	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SNAPC4	0.06	0.04	lasso	2	0.05	9.0e-07	7.45	-6.5	1.0e-10	-0.87	0.70	0.28	FALSE
3	GTEx	Artery Tibial	SDCCAG3	0.05	0.00	lasso	4	0.00	2.2e-01	-6.48	-7.1	1.5e-12	-0.75	0.03	0.91	FALSE
4	GTEx	Brain Caudate basal ganglia	INPP5E	0.23	0.20	enet	8	0.22	7.2e-07	5.98	-6.2	7.7e-10	-0.73	0.38	0.38	FALSE
5	GTEx	Brain Cerebellar Hemisphere	INPP5E	0.25	0.23	enet	6	0.17	3.4e-05	5.77	-6.4	1.4e-10	-0.76	0.28	0.59	FALSE
6	GTEx	Brain Cerebellum	INPP5E	0.40	0.30	enet	20	0.29	3.6e-09	5.98	-6.0	2.0e-09	-0.72	0.85	0.14	FALSE
7	GTEx	Brain Putamen basal ganglia	INPP5E	0.28	0.20	enet	6	0.01	2.2e-01	5.39	-6.0	2.2e-09	-0.80	0.12	0.66	FALSE
8	GTEx	Cells EBV-transformed lymphocytes	INPP5E	0.27	0.05	enet	21	0.14	2.0e-05	5.77	-5.9	3.3e-09	-0.50	0.10	0.39	FALSE
9	GTEx	Cells Transformed fibroblasts	SDCCAG3	0.12	0.03	enet	21	0.06	5.4e-05	4.21	-5.6	2.6e-08	-0.72	0.72	0.27	FALSE
10	GTEx	Cells Transformed fibroblasts	CARD9	0.10	0.01	enet	15	0.02	8.0e-03	-6.09	-7.9	3.3e-15	-0.55	0.06	0.84	FALSE
11	GTEx	Colon Sigmoid	INPP5E	0.22	0.10	lasso	3	0.01	1.6e-01	7.34	-7.5	6.2e-14	-0.95	0.02	0.96	FALSE
12	GTEx	Esophagus Mucosa	INPP5E	0.11	0.12	lasso	3	0.12	1.0e-08	5.77	-6.1	1.4e-09	-0.65	0.95	0.04	FALSE
13	GTEx	Esophagus Muscularis	SDCCAG3	0.10	0.02	enet	5	0.02	3.6e-02	4.10	-5.5	3.2e-08	-0.46	0.20	0.25	FALSE
14	GTEx	Heart Atrial Appendage	INPP5E	0.13	0.12	lasso	2	0.10	3.5e-05	5.50	-5.5	3.7e-08	-0.61	0.23	0.28	FALSE
15	GTEx	Lung	INPP5E	0.10	0.05	enet	13	0.04	6.1e-04	5.98	-6.0	1.6e-09	-0.72	0.58	0.24	FALSE
16	GTEx	Lung	CARD9	0.08	0.04	enet	6	0.04	2.5e-04	5.35	6.9	5.0e-12	0.87	0.02	0.98	FALSE
17	GTEx	Muscle Skeletal	CARD9	0.16	0.12	enet	28	0.11	9.0e-11	-6.09	-7.1	1.2e-12	-0.27	1.00	0.00	TRUE
18	GTEx	Nerve Tibial	INPP5E	0.13	0.17	enet	10	0.14	3.7e-10	5.98	-5.9	3.2e-09	-0.66	1.00	0.00	FALSE
19	GTEx	Ovary	INPP5E	0.24	0.13	enet	11	0.15	1.9e-04	6.38	-6.7	2.5e-11	-0.80	0.08	0.53	FALSE
20	GTEx	Pancreas	SEC16A	0.28	0.10	enet	16	0.16	4.1e-07	5.59	-6.3	4.0e-10	-0.51	0.52	0.42	FALSE
21	GTEx	Pituitary	INPP5E	0.21	0.24	lasso	3	0.14	1.8e-04	5.98	5.6	2.5e-08	0.60	0.14	0.53	FALSE
22	GTEx	Skin Sun Exposed Lower leg	INPP5E	0.10	0.10	lasso	2	0.09	5.2e-08	5.77	-6.0	2.5e-09	-0.73	0.92	0.08	FALSE
23	GTEx	Skin Sun Exposed Lower leg	RP11-611D20.2	0.21	0.16	enet	16	0.17	3.3e-14	2.73	5.4	7.2e-08	0.16	1.00	0.00	TRUE
24	GTEx	Spleen	PMPCA	0.24	0.15	lasso	2	0.10	1.7e-03	5.91	5.2	1.9e-07	0.65	0.03	0.61	FALSE
25	GTEx	Stomach	SEC16A	0.15	0.09	lasso	4	0.10	1.8e-05	5.59	-6.1	9.6e-10	-0.60	0.62	0.28	FALSE
26	GTEx	Testis	INPP5E	0.24	0.32	enet	10	0.30	5.4e-14	5.98	-6.1	1.3e-09	-0.70	1.00	0.00	FALSE
27	GTEx	Testis	SDCCAG3	0.15	0.09	lasso	4	0.13	3.3e-06	4.21	-5.9	3.1e-09	-0.66	0.46	0.40	FALSE
28	GTEx	Thyroid	INPP5E	0.23	0.35	enet	16	0.37	8.2e-30	5.79	-6.5	6.8e-11	-0.81	0.88	0.12	FALSE
29	GTEx	Thyroid	PMPCA	0.10	0.05	enet	11	0.10	8.7e-08	4.94	-5.7	9.5e-09	-0.57	0.33	0.65	FALSE
30	GTEx	Uterus	INPP5E	0.60	0.04	enet	10	0.22	3.4e-05	6.46	-6.4	1.3e-10	-0.73	0.06	0.51	FALSE
31	GTEx	Whole Blood	SEC16A	0.07	0.05	lasso	5	0.04	1.3e-04	5.59	-5.8	7.0e-09	-0.63	0.67	0.29	FALSE
32	GTEx	Whole Blood	SDCCAG3	0.07	0.03	enet	6	0.02	3.4e-03	4.93	-6.5	5.9e-11	-0.84	0.02	0.98	FALSE
33	GTEx	Whole Blood	CARD9	0.08	0.07	lasso	1	0.05	4.2e-05	7.85	7.9	4.1e-15	0.99	0.02	0.98	FALSE
34	METSIM	Adipose	CARD9	0.04	0.05	enet	6	0.06	5.9e-09	-6.48	7.5	4.8e-14	0.78	0.14	0.86	FALSE
35	YFS	Blood	CARD9	0.22	0.37	lasso	5	0.39	1.3e-137	8.27	8.1	4.9e-16	0.97	0.00	1.00	TRUE
36	YFS	Blood	INPP5E	0.33	0.55	lasso	6	0.57	2.9e-235	6.46	-6.4	1.6e-10	-0.71	1.00	0.00	FALSE
37	YFS	Blood	PMPCA	0.03	0.01	lasso	5	0.02	2.7e-07	5.79	5.8	5.4e-09	0.79	0.08	0.92	FALSE
38	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SEC16A	0.12	0.02	enet	10	0.03	2.2e-03	-0.86	-5.4	6.6e-08	-0.33	0.06	0.06	FALSE
39	The Cancer Genome Atlas	Breast Invasive Carcinoma	SDCCAG3	0.05	0.01	blup	61	0.01	7.9e-04	5.59	-5.1	3.0e-07	-0.47	0.07	0.14	FALSE
40	The Cancer Genome Atlas	Breast Invasive Carcinoma	SEC16A	0.02	0.00	blup	69	0.01	1.0e-03	5.98	-7.6	4.0e-14	-0.67	0.11	0.40	FALSE
41	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	INPP5E	0.25	0.10	lasso	3	0.09	4.9e-05	6.46	-6.5	7.7e-11	-0.71	0.30	0.19	FALSE
42	The Cancer Genome Atlas	Colon Adenocarcinoma	INPP5E	0.11	0.08	lasso	2	0.08	3.4e-05	6.46	-6.4	1.2e-10	-0.72	0.14	0.17	FALSE
43	The Cancer Genome Atlas	Colon Adenocarcinoma	SDCCAG3	0.08	0.01	lasso	4	0.02	3.1e-02	3.44	-5.2	1.5e-07	-0.69	0.04	0.19	FALSE
44	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	INPP5E	0.03	0.01	blup	54	0.01	1.1e-02	6.44	-6.6	4.4e-11	-0.82	0.01	0.74	FALSE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SDCCAG3	0.04	0.05	enet	6	0.04	5.1e-05	3.44	-5.1	3.0e-07	-0.74	0.56	0.38	FALSE
46	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	INPP5E	0.07	0.04	blup	54	0.07	6.0e-05	4.85	-7.1	9.9e-13	-0.82	0.04	0.86	FALSE
47	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SDCCAG3	0.05	0.01	blup	61	0.01	5.9e-02	5.04	-6.5	7.1e-11	-0.85	0.03	0.60	FALSE
48	The Cancer Genome Atlas	Brain Lower Grade Glioma	INPP5E	0.04	0.02	blup	54	0.03	4.4e-04	5.98	-6.1	9.5e-10	-0.68	0.20	0.41	FALSE
49	The Cancer Genome Atlas	Prostate Adenocarcinoma	SDCCAG3	0.08	0.05	lasso	2	0.05	3.3e-06	3.44	-5.2	1.8e-07	-0.76	0.57	0.36	FALSE
50	The Cancer Genome Atlas	Prostate Adenocarcinoma	SEC16A	0.08	0.10	lasso	4	0.08	1.9e-08	4.84	-5.2	2.0e-07	-0.58	1.00	0.00	FALSE
51	The Cancer Genome Atlas	Testicular Germ Cell Tumors	INPP5E	0.10	0.06	blup	54	0.08	8.1e-04	5.77	-6.7	1.6e-11	-0.84	0.03	0.74	FALSE
52	The Cancer Genome Atlas	Thyroid Carcinoma	INPP5E	0.11	0.16	lasso	3	0.16	2.4e-15	6.44	-6.3	2.5e-10	-0.83	0.80	0.20	FALSE